WO2007011571A3 - Digitizing biology - Google Patents

Digitizing biology Download PDF

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Publication number
WO2007011571A3
WO2007011571A3 PCT/US2006/026777 US2006026777W WO2007011571A3 WO 2007011571 A3 WO2007011571 A3 WO 2007011571A3 US 2006026777 W US2006026777 W US 2006026777W WO 2007011571 A3 WO2007011571 A3 WO 2007011571A3
Authority
WO
WIPO (PCT)
Prior art keywords
vector space
light
target data
determined
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/026777
Other languages
French (fr)
Other versions
WO2007011571A2 (en
Inventor
John S Maier
Patrick J Treado
Jeffrey Cohen
Jason Neiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChemImage Corp
Original Assignee
ChemImage Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/000,591 external-priority patent/US7697576B2/en
Application filed by ChemImage Corp filed Critical ChemImage Corp
Priority to CA002614319A priority Critical patent/CA2614319A1/en
Priority to EP06786809A priority patent/EP1906814A2/en
Publication of WO2007011571A2 publication Critical patent/WO2007011571A2/en
Publication of WO2007011571A3 publication Critical patent/WO2007011571A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
PCT/US2006/026777 2004-05-05 2006-07-11 Digitizing biology Ceased WO2007011571A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002614319A CA2614319A1 (en) 2005-07-15 2006-07-11 Digitizing biology
EP06786809A EP1906814A2 (en) 2005-07-15 2006-07-11 Digitizing biology

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56835704P 2004-05-05 2004-05-05
US11/000,591 US7697576B2 (en) 2004-05-05 2004-11-30 Cytological analysis by raman spectroscopic imaging
US68880105P 2005-06-09 2005-06-09
US69946105P 2005-07-15 2005-07-15
US60/699,461 2005-07-15
US80155906P 2006-05-18 2006-05-18

Publications (2)

Publication Number Publication Date
WO2007011571A2 WO2007011571A2 (en) 2007-01-25
WO2007011571A3 true WO2007011571A3 (en) 2007-06-07

Family

ID=37395076

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/026777 Ceased WO2007011571A2 (en) 2004-05-05 2006-07-11 Digitizing biology

Country Status (1)

Country Link
WO (1) WO2007011571A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7697576B2 (en) 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US9622825B2 (en) * 2011-11-28 2017-04-18 National University Of Singapore Robotic system for flexible endoscopy
DE102014003386B4 (en) * 2014-03-07 2016-06-23 Celltool Gmbh Method and device for quality control of a blood product
US11674903B2 (en) 2014-04-23 2023-06-13 Virginia Tech Intellectual Properties, Inc. System and method for monitoring the health of dialysis patients
US11959858B2 (en) * 2020-06-11 2024-04-16 Virginia Tech Intellectual Properties, Inc. Method and system for high-throughput screening

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201989B1 (en) * 1997-03-13 2001-03-13 Biomax Technologies Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US6289236B1 (en) * 1997-10-10 2001-09-11 The General Hospital Corporation Methods and apparatus for distinguishing inflamed and tumorous bladder tissue
US20030018272A1 (en) * 2001-06-28 2003-01-23 Treado Patrick J. Method for Raman chemical imaging and characterization of calcification in tissue
US20040010197A1 (en) * 1998-09-11 2004-01-15 Spectrx, Inc Multi-modal optical tissue diagnostic system
US6826422B1 (en) * 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US6885965B2 (en) * 2002-05-22 2005-04-26 First Responder Systems Technologies, Llc Processing system for remote chemical identification

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6826422B1 (en) * 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US6201989B1 (en) * 1997-03-13 2001-03-13 Biomax Technologies Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US6289236B1 (en) * 1997-10-10 2001-09-11 The General Hospital Corporation Methods and apparatus for distinguishing inflamed and tumorous bladder tissue
US20040010197A1 (en) * 1998-09-11 2004-01-15 Spectrx, Inc Multi-modal optical tissue diagnostic system
US20030018272A1 (en) * 2001-06-28 2003-01-23 Treado Patrick J. Method for Raman chemical imaging and characterization of calcification in tissue
US6885965B2 (en) * 2002-05-22 2005-04-26 First Responder Systems Technologies, Llc Processing system for remote chemical identification

Also Published As

Publication number Publication date
WO2007011571A2 (en) 2007-01-25

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WO2007011571A3 (en) Digitizing biology

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