WO2007015208A3 - Injectable composite material suitable for use as a bone substitute - Google Patents

Injectable composite material suitable for use as a bone substitute Download PDF

Info

Publication number
WO2007015208A3
WO2007015208A3 PCT/IB2006/052623 IB2006052623W WO2007015208A3 WO 2007015208 A3 WO2007015208 A3 WO 2007015208A3 IB 2006052623 W IB2006052623 W IB 2006052623W WO 2007015208 A3 WO2007015208 A3 WO 2007015208A3
Authority
WO
WIPO (PCT)
Prior art keywords
composite material
bone substitute
material suitable
injectable composite
injectable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/052623
Other languages
French (fr)
Other versions
WO2007015208A2 (en
Inventor
Luigi Ambrosio
Valeria Sanginario
Maria Pau Ginebra
Josep Anton Planell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consiglio Nazionale delle Richerche CNR
Original Assignee
Consiglio Nazionale delle Richerche CNR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP06780262A priority Critical patent/EP1924302B1/en
Priority to SM200800013T priority patent/SMAP200800013A/en
Priority to NZ566086A priority patent/NZ566086A/en
Priority to DK06780262.9T priority patent/DK1924302T3/en
Priority to CN2006800286341A priority patent/CN101257937B/en
Priority to US11/997,211 priority patent/US20080220086A1/en
Priority to BRPI0615994-0A priority patent/BRPI0615994A2/en
Priority to JP2008524655A priority patent/JP5180075B2/en
Priority to AU2006274594A priority patent/AU2006274594B2/en
Priority to DE602006014004T priority patent/DE602006014004D1/en
Priority to SI200630731T priority patent/SI1924302T1/en
Priority to CA002617721A priority patent/CA2617721A1/en
Application filed by Consiglio Nazionale delle Richerche CNR filed Critical Consiglio Nazionale delle Richerche CNR
Priority to KR1020087005280A priority patent/KR101276632B1/en
Priority to PL06780262T priority patent/PL1924302T3/en
Priority to AT06780262T priority patent/ATE465762T1/en
Publication of WO2007015208A2 publication Critical patent/WO2007015208A2/en
Publication of WO2007015208A3 publication Critical patent/WO2007015208A3/en
Anticipated expiration legal-status Critical
Priority to US12/979,818 priority patent/US8231909B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a new injectable composite material suitable for use as a bone substitute. The composite material according to the invention comprises a reactive ceramic phase based on tricalcium phosphate and an organic phase comprising a polyvinyl alcohol hydrogel . By varying the concentration of the two phases it is possible to modulate the mechanical and injectability properties of the material.
PCT/IB2006/052623 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute Ceased WO2007015208A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
SI200630731T SI1924302T1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
NZ566086A NZ566086A (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
DK06780262.9T DK1924302T3 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as bone substitute
CN2006800286341A CN101257937B (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute, uses and preparation method thereof
US11/997,211 US20080220086A1 (en) 2005-08-03 2006-08-01 Injectable Composite Material Suitable for Use as a Bone Substitute
BRPI0615994-0A BRPI0615994A2 (en) 2005-08-03 2006-08-01 injectable compound material suitable for use as a bone substitute
JP2008524655A JP5180075B2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
AU2006274594A AU2006274594B2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
DE602006014004T DE602006014004D1 (en) 2005-08-03 2006-08-01 INJECTABLE COMPOSITE MATERIAL FOR USE AS BONE REPLACEMENT
EP06780262A EP1924302B1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
SM200800013T SMAP200800013A (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
CA002617721A CA2617721A1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
KR1020087005280A KR101276632B1 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
PL06780262T PL1924302T3 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute
AT06780262T ATE465762T1 (en) 2005-08-03 2006-08-01 INJECTABLE COMPOSITE MATERIAL FOR USE AS BONE REPLACEMENT
US12/979,818 US8231909B2 (en) 2005-08-03 2010-12-28 Injectable composite material suitable for use as a bone substitute

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000549A ITTO20050549A1 (en) 2005-08-03 2005-08-03 COMPOSITE MATERIAL INJECTABLE TO BE USED AS A BONUS SUBSTITUTE
ITTO2005A000549 2005-08-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/997,211 A-371-Of-International US20080220086A1 (en) 2005-08-03 2006-08-01 Injectable Composite Material Suitable for Use as a Bone Substitute
US12/979,818 Continuation US8231909B2 (en) 2005-08-03 2010-12-28 Injectable composite material suitable for use as a bone substitute

Publications (2)

Publication Number Publication Date
WO2007015208A2 WO2007015208A2 (en) 2007-02-08
WO2007015208A3 true WO2007015208A3 (en) 2007-05-31

Family

ID=37667630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/052623 Ceased WO2007015208A2 (en) 2005-08-03 2006-08-01 Injectable composite material suitable for use as a bone substitute

Country Status (22)

Country Link
US (2) US20080220086A1 (en)
EP (1) EP1924302B1 (en)
JP (1) JP5180075B2 (en)
KR (1) KR101276632B1 (en)
CN (1) CN101257937B (en)
AT (1) ATE465762T1 (en)
AU (1) AU2006274594B2 (en)
BR (1) BRPI0615994A2 (en)
CA (1) CA2617721A1 (en)
DE (1) DE602006014004D1 (en)
DK (1) DK1924302T3 (en)
ES (1) ES2345399T3 (en)
IT (1) ITTO20050549A1 (en)
NZ (1) NZ566086A (en)
PL (1) PL1924302T3 (en)
PT (1) PT1924302E (en)
RU (1) RU2407552C2 (en)
SI (1) SI1924302T1 (en)
SM (1) SMAP200800013A (en)
UA (1) UA92027C2 (en)
WO (1) WO2007015208A2 (en)
ZA (1) ZA200801928B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US7985781B2 (en) 2004-10-12 2011-07-26 Zimmer Gmbh PVA hydrogel
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8262730B2 (en) 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
US20100226956A1 (en) 2009-03-06 2010-09-09 Per Kjellin Production of moldable bone substitute
WO2017015703A1 (en) 2015-07-24 2017-02-02 The University Of Sydney Antiseptic polymer and synthesis thereof
JP2020067494A (en) * 2018-10-22 2020-04-30 ウェトラブ株式会社 Head model for neurosurgical operation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449818A1 (en) * 2001-10-21 2004-08-25 National Institute of Advanced Industrial Science and Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same
WO2005025595A2 (en) * 2003-09-12 2005-03-24 Wyeth Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3635316B2 (en) * 1996-11-25 2005-04-06 株式会社アドバンス Method for producing spherical ceramic porous body
RU2251405C2 (en) * 2000-03-27 2005-05-10 Шотт Глас Compositions for cosmetic preparations, means for personal hygiene, components of purifying action, food additives, methods for their obtaining and application
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1449818A1 (en) * 2001-10-21 2004-08-25 National Institute of Advanced Industrial Science and Technology Porous article of sintered calcium phosphate, process for producing the same and artificial bone and histomorphological scaffold using the same
WO2005025595A2 (en) * 2003-09-12 2005-03-24 Wyeth Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOHNER M ET AL: "Injectability of calcium phosphate pastes", BIOMATERIALS, vol. 26, no. 13, May 2005 (2005-05-01), pages 1553 - 1563, XP004621565, ISSN: 0142-9612 *
LANDI, E. ET AL: "Calcium phosphate ceramics as drug-delivery system for anticancer therapy", KEY ENGINEERING MATERIALS, vol. 192-195, 2001, pages 901 - 904, XP009077952, ISSN: 1013-9826 *
SANGINARIO, V. ET AL: "Injectable composite hydrogels for orthopedic applications. Mechanical and morphological analysis", KEY ENGINEERING MATERIALS, vol. 254-256, 2004, pages 485 - 488, XP009077965, ISSN: 1013-9826 *
TAS, A. C.: "Preparation of porous bioceramics by a simple PVA-processing route", KEY ENGINEERING MATERIALS, vol. 264-268, 2004, pages 2079 - 2082, XP009077951, ISSN: 1013-9826 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985781B2 (en) 2004-10-12 2011-07-26 Zimmer Gmbh PVA hydrogel
US8262730B2 (en) 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces

Also Published As

Publication number Publication date
SMP200800013B (en) 2008-02-27
AU2006274594B2 (en) 2011-12-22
ITTO20050549A1 (en) 2007-02-04
ATE465762T1 (en) 2010-05-15
KR101276632B1 (en) 2013-06-18
EP1924302B1 (en) 2010-04-28
AU2006274594A1 (en) 2007-02-08
CN101257937A (en) 2008-09-03
PL1924302T3 (en) 2010-10-29
JP5180075B2 (en) 2013-04-10
CA2617721A1 (en) 2007-02-08
KR20080041678A (en) 2008-05-13
RU2008108014A (en) 2009-09-10
NZ566086A (en) 2011-03-31
PT1924302E (en) 2010-07-27
SMAP200800013A (en) 2008-02-27
BRPI0615994A2 (en) 2011-05-31
EP1924302A2 (en) 2008-05-28
RU2407552C2 (en) 2010-12-27
UA92027C2 (en) 2010-09-27
US20080220086A1 (en) 2008-09-11
US8231909B2 (en) 2012-07-31
CN101257937B (en) 2013-03-20
JP2009502405A (en) 2009-01-29
ES2345399T3 (en) 2010-09-22
ZA200801928B (en) 2009-07-29
US20110091554A1 (en) 2011-04-21
DE602006014004D1 (en) 2010-06-10
WO2007015208A2 (en) 2007-02-08
DK1924302T3 (en) 2010-07-26
SI1924302T1 (en) 2010-09-30

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