WO2007015824A3 - Novel macrocyclic inhibitors of hepatitis c virus replication - Google Patents

Novel macrocyclic inhibitors of hepatitis c virus replication Download PDF

Info

Publication number
WO2007015824A3
WO2007015824A3 PCT/US2006/027738 US2006027738W WO2007015824A3 WO 2007015824 A3 WO2007015824 A3 WO 2007015824A3 US 2006027738 W US2006027738 W US 2006027738W WO 2007015824 A3 WO2007015824 A3 WO 2007015824A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
methods
virus replication
novel macrocyclic
macrocyclic inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/027738
Other languages
French (fr)
Other versions
WO2007015824A2 (en
Inventor
Scott D Seiwert
Lawrence M Blatt
Steven W Andrews
Pierre Martin
Andreas Schumacher
Bradley R Barnett
Todd C Eary
Robert Kaus
Timothy Kercher
Weidong Liu
Michael Lyon
Paul Nichols
Bin Wang
Tarek Sammakia
April Kennedy
Yutong Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Array Biopharma Inc
Intermune Inc
Original Assignee
Array Biopharma Inc
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008523949A priority Critical patent/JP5249028B2/en
Priority to US11/996,902 priority patent/US20090148407A1/en
Priority to BRPI0613962-0A priority patent/BRPI0613962A2/en
Priority to NZ594105A priority patent/NZ594105A/en
Priority to EA200800413A priority patent/EA015752B1/en
Priority to CNA2006800272902A priority patent/CN101263156A/en
Priority to KR1020087004379A priority patent/KR101294467B1/en
Priority to NZ565059A priority patent/NZ565059A/en
Priority to EP06800088A priority patent/EP1924594A2/en
Priority to CA2615666A priority patent/CA2615666C/en
Priority to AU2006276246A priority patent/AU2006276246B2/en
Application filed by Array Biopharma Inc, Intermune Inc filed Critical Array Biopharma Inc
Priority to MX2008001166A priority patent/MX2008001166A/en
Publication of WO2007015824A2 publication Critical patent/WO2007015824A2/en
Publication of WO2007015824A3 publication Critical patent/WO2007015824A3/en
Priority to IL188693A priority patent/IL188693A/en
Priority to IL221361A priority patent/IL221361A/en
Priority to TNP2008000022A priority patent/TNSN08022A1/en
Anticipated expiration legal-status Critical
Priority to NO20080875A priority patent/NO20080875L/en
Priority to US13/450,885 priority patent/US8299021B2/en
Priority to IL221361A priority patent/IL221361A0/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
PCT/US2006/027738 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication Ceased WO2007015824A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
AU2006276246A AU2006276246B2 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis C virus replication
BRPI0613962-0A BRPI0613962A2 (en) 2005-07-25 2006-07-17 innovative macrocyclic hepatitis c virus replication inhibitors
NZ594105A NZ594105A (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication
EA200800413A EA015752B1 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication
CNA2006800272902A CN101263156A (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis C virus replication
KR1020087004379A KR101294467B1 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication
MX2008001166A MX2008001166A (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication.
US11/996,902 US20090148407A1 (en) 2005-07-25 2006-07-17 Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication
CA2615666A CA2615666C (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication
JP2008523949A JP5249028B2 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitor of hepatitis C virus replication
EP06800088A EP1924594A2 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication
NZ565059A NZ565059A (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitus C virus replication
IL188693A IL188693A (en) 2005-07-25 2008-01-09 Macrocyclic inhibitors of hepatitis c virus replication
IL221361A IL221361A (en) 2005-07-25 2008-01-09 Macrocyclic inhibitors of hepatitis c virus replication
TNP2008000022A TNSN08022A1 (en) 2005-07-25 2008-01-18 Novel macrocyclic inhibitors of hepatitis c virus replication
NO20080875A NO20080875L (en) 2005-07-25 2008-02-19 New macrocyclic inhibitors of hepatitis C virus replication
US13/450,885 US8299021B2 (en) 2005-07-25 2012-04-19 Macrocyclic inhibitors of hepatitis C virus replication
IL221361A IL221361A0 (en) 2005-07-25 2012-08-08 Novel macrocyclic inhibitors of hepatitis c virus replication

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US70219505P 2005-07-25 2005-07-25
US60/702,195 2005-07-25
US72553305P 2005-10-11 2005-10-11
US60/725,533 2005-10-11
US78980006P 2006-04-06 2006-04-06
US60/789,800 2006-04-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/996,902 A-371-Of-International US20090148407A1 (en) 2005-07-25 2006-07-17 Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication
US13/450,885 Continuation US8299021B2 (en) 2005-07-25 2012-04-19 Macrocyclic inhibitors of hepatitis C virus replication

Publications (2)

Publication Number Publication Date
WO2007015824A2 WO2007015824A2 (en) 2007-02-08
WO2007015824A3 true WO2007015824A3 (en) 2007-07-19

Family

ID=37433829

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027738 Ceased WO2007015824A2 (en) 2005-07-25 2006-07-17 Novel macrocyclic inhibitors of hepatitis c virus replication

Country Status (23)

Country Link
US (4) US20090148407A1 (en)
EP (6) EP2305698A3 (en)
JP (2) JP5249028B2 (en)
KR (1) KR101294467B1 (en)
CN (2) CN102816170A (en)
AR (1) AR055095A1 (en)
AU (1) AU2006276246B2 (en)
BR (1) BRPI0613962A2 (en)
CA (1) CA2615666C (en)
CU (1) CU23794B7 (en)
EA (2) EA019888B1 (en)
EC (1) ECSP088208A (en)
GE (1) GEP20105124B (en)
IL (3) IL188693A (en)
MA (1) MA29746B1 (en)
MX (1) MX2008001166A (en)
MY (1) MY148690A (en)
NO (1) NO20080875L (en)
NZ (2) NZ565059A (en)
SG (1) SG166791A1 (en)
TN (1) TNSN08022A1 (en)
TW (1) TW200740851A (en)
WO (1) WO2007015824A2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8889871B2 (en) 2002-05-20 2014-11-18 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US9296782B2 (en) 2012-07-03 2016-03-29 Gilead Sciences, Inc. Inhibitors of hepatitis C virus
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9617310B2 (en) 2013-03-15 2017-04-11 Gilead Sciences, Inc. Inhibitors of hepatitis C virus

Families Citing this family (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100891887B1 (en) 2001-01-29 2009-04-03 시오노기세이야쿠가부시키가이샤 Pharmaceutical preparations containing 5-methyl-1-phenyl-2- (1H) -pyridone as active ingredient
JP2003007697A (en) * 2001-06-21 2003-01-10 Hitachi Kokusai Electric Inc Semiconductor device manufacturing method, substrate processing method and substrate processing apparatus
AU2006276246B2 (en) * 2005-07-25 2012-09-27 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis C virus replication
NZ591443A (en) 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
ES2356776T3 (en) 2005-10-11 2011-04-13 Intermune, Inc. COMPOUNDS AND METHODS TO INHIBIT THE REPLICATION OF THE HEPATITIS VIRUS.
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
RU2008152171A (en) 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) NEW HEPATITIS C VIRAL REPLICATION INHIBITORS
TW200819460A (en) * 2006-07-07 2008-05-01 Gilead Sciences Inc Antiviral phosphinate compounds
US7935670B2 (en) 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2041156E (en) 2006-07-13 2014-02-21 Achillion Pharmaceuticals Inc 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US7605126B2 (en) * 2006-08-11 2009-10-20 Enanta Pharmaceuticals, Inc. Acylaminoheteroaryl hepatitis C virus protease inhibitors
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) * 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2008070358A2 (en) * 2006-11-16 2008-06-12 Phenomix Corporation N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2102353A2 (en) * 2006-12-04 2009-09-23 DSM IP Assets B.V. Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase
SI2124945T1 (en) * 2006-12-18 2011-08-31 Intermune Inc Method of providing pirfenidone therapy to a patient
WO2008086161A1 (en) * 2007-01-08 2008-07-17 Phenomix Corporation Macrocyclic hepatitis c protease inhibitors
SG174809A1 (en) * 2007-05-03 2011-10-28 Intermune Inc Macrocyclic compounds useful as inhibitors of hepatitis c virus
JP2010526834A (en) * 2007-05-10 2010-08-05 インターミューン・インコーポレーテッド Novel peptide inhibitors of hepatitis C virus replication
WO2009005690A2 (en) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Antiviral compounds
AP2009005073A0 (en) * 2007-06-29 2009-12-31 Gilead Sciences Inc Antiviral compounds
NZ582096A (en) * 2007-06-29 2012-05-25 Gilead Sciences Inc Antiviral compounds that inhibit hepatitis c virus (hcv)
MX2007009796A (en) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel containing pirfenidone.
US8419332B2 (en) * 2007-10-19 2013-04-16 Atlas Bolt & Screw Company Llc Non-dimpling fastener
WO2009053828A2 (en) * 2007-10-22 2009-04-30 Enanta Pharmaceuticals, Inc. P3 hydroxyamino macrocyclic hepatitis c serine protease inhibitors
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
CL2008003384A1 (en) * 2007-11-14 2009-12-11 Enanta Pharm Inc Macrocyclic quinoxaline derived compounds, serine protease inhibitors; pharmaceutical composition comprising them; and its use in the treatment of hepatitis c.
EP2222161A4 (en) 2007-12-05 2011-09-28 Enanta Pharm Inc Quinoxalinyl derivatives
MX2010006210A (en) 2007-12-05 2010-08-10 Enanta Pharm Inc Fluorinated tripeptide hcv serine protease inhibitors.
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
MX2010006659A (en) * 2007-12-21 2010-07-05 Hoffmann La Roche Process for the preparation of a macrocycle.
TWI487522B (en) 2007-12-21 2015-06-11 賽基艾維洛米斯研究股份有限公司 Hcv protease inhibitors and uses thereof
US8309685B2 (en) 2007-12-21 2012-11-13 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
RU2515318C2 (en) * 2007-12-21 2014-05-10 Авила Терапьютикс, Инк. Inhibitors of protease of hepatitis c virus and their application
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
AU2015224437B2 (en) * 2007-12-21 2017-05-25 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
ES2437147T3 (en) 2008-02-04 2014-01-09 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
CN102015652A (en) 2008-03-20 2011-04-13 益安药业 Fluorinated macrocyclic compounds as hepatitis c virus inhibitors
PL2276725T3 (en) 2008-04-11 2012-11-30 Hoffmann La Roche New ruthenium complexes as catalysts for metathesis reactions
WO2009142842A2 (en) * 2008-04-15 2009-11-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20090285773A1 (en) * 2008-05-15 2009-11-19 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2300491B1 (en) 2008-05-29 2016-01-06 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2009152051A1 (en) * 2008-06-12 2009-12-17 Phenomix Corporation Synthesis of a macrocyclic hcv protease inhibitor
KR101647520B1 (en) * 2008-08-07 2016-08-10 에프. 호프만-라 로슈 아게 Process for the preparation of a macrocycle
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (en) 2008-09-11 2010-04-30 Enanta Pharm Inc HEPATITIS C SERINA PROTEASAS MACROCYCLIC INHIBITORS
PT2350075E (en) 2008-09-22 2014-06-09 Array Biopharma Inc Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2341924A4 (en) 2008-10-02 2013-01-23 David Gladstone Inst METHODS OF TREATING HEPATITIS C VIRUS INFECTION
KR20110075019A (en) * 2008-10-15 2011-07-05 인터뮨, 인크. Therapeutic Antiviral Peptides
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
AR074052A1 (en) 2008-10-22 2010-12-22 Array Biopharma Inc PIRAZOLO COMPOUNDS {1,5-A} PIRIMIDINE REPLACED AS TRK CINASA INHIBITORS
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
US7566729B1 (en) 2008-11-10 2009-07-28 Intermune, Inc. Modifying pirfenidone treatment for patients with atypical liver function
EP2364309B1 (en) 2008-12-10 2014-10-01 Achillion Pharmaceuticals, Inc. New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20110098849A (en) 2008-12-23 2011-09-01 파마셋 인코포레이티드 Nucleoside analogues
PT2376088T (en) 2008-12-23 2017-05-02 Gilead Pharmasset Llc 6-o-substituted-2-amino-purine nucleoside phosphoramidates
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
AU2010206543A1 (en) * 2009-01-26 2011-07-07 Intermune, Inc. Methods for treating acute myocardial infarctions and associated disorders
US8102720B2 (en) * 2009-02-02 2012-01-24 Qualcomm Incorporated System and method of pulse generation
AR075584A1 (en) * 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS THAT INCLUDE beta-D-2'-DESOXI-2'-FLUORO-2'-C-METHYLYCTIDINE AND A CARDIEX ISOINDOL ACID DERIVATIVE AND ITS USES. COMPOUND.
EP2403860B1 (en) 2009-03-04 2015-11-04 IDENIX Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole as hcv polymerase inhibitors
TWI598358B (en) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8232246B2 (en) * 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
RU2602814C2 (en) 2009-09-25 2016-11-20 Оризон Дженомикс С.А. Lysin-specific demethylase-1 inhibitors and use thereof
CN102741270B (en) 2009-09-28 2015-07-22 英特穆恩公司 Cyclic peptide inhibitors of hepatitis C virus replication
MX2012003171A (en) * 2009-09-28 2012-04-11 Hoffmann La Roche Novel macrocyclic inhibitors of hepatitis c virus replication.
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
US9193740B2 (en) * 2009-10-19 2015-11-24 Enanta Pharmaceuticals, Inc. Bismacrocyclic compounds as hepatitis C virus inhibitors
US20110117055A1 (en) 2009-11-19 2011-05-19 Macdonald James E Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds
US8084475B2 (en) * 2009-12-04 2011-12-27 Intermune, Inc. Pirfenidone therapy and inducers of cytochrome P450
US7816383B1 (en) 2009-12-04 2010-10-19 Intermune, Inc. Methods of administering pirfenidone therapy
KR20120118008A (en) 2009-12-18 2012-10-25 아이데닉스 파마슈티칼스, 인코포레이티드 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
MA34013B1 (en) 2010-01-25 2013-02-01 Enanta Pharm Inc Hepatitis C inhibitors c
US8933110B2 (en) * 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
JP5613660B2 (en) 2010-02-16 2014-10-29 株式会社エーピーアイ コーポレーション Process for producing 1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
WO2011106574A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
US8324212B2 (en) * 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
UY33312A (en) 2010-03-31 2011-10-31 Pharmasset Inc PURINE NUCLEOSIDE PHOSPHORAMIDATE
PT2609923T (en) 2010-03-31 2017-08-30 Gilead Pharmasset Llc Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
PL3290428T3 (en) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tablet comprising crystalline (s)-isopropyl 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1 (2h)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
RS55348B1 (en) 2010-04-19 2017-03-31 Oryzon Gnomics S A LYSINE INHIBITORS SPECIFIC DEMETHYLASE-1 AND THEIR USE
NZ604708A (en) 2010-05-20 2015-05-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
EP2598480B1 (en) 2010-07-29 2019-04-24 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
WO2012013728A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
SG188618A1 (en) * 2010-09-21 2013-04-30 Enanta Pharm Inc Macrocyclic proline derived hcv serine protease inhibitors
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) * 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
EP2658859A4 (en) 2010-12-30 2014-07-30 Enanta Pharm Inc Macrocyclic hepatitis c serine protease inhibitors
KR20140003521A (en) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 Phenanthridine macrocyclic hepatitis c serine protease inhibitors
JP6021117B2 (en) 2011-01-31 2016-11-02 ジェノア ファーマシューティカルズ，インク． Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MX2011007675A (en) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Process for manufacturing a pharmaceutical composition in a sustained-release tablet form containing pirfenidone and the application thereof in the regression of chronic renal failure, breast capsular contracture and liver fibrosis in humans.
PL2709613T5 (en) 2011-09-16 2020-12-14 Gilead Pharmasset Llc Methods for treating hcv
MX356344B (en) 2011-10-20 2018-05-23 Oryzon Genomics Sa (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors.
RU2668952C2 (en) 2011-10-20 2018-10-05 Оризон Дженомикс, С.А. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
CA2863002A1 (en) 2012-01-11 2013-07-18 Abbvie Inc. Processes for making hcv protease inhibitors
MX346763B (en) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V SEMISOLID TOPIC COMPOSITION CONTAINING PYRFENIDONE AND DIALYL MODIFIED DISULFIDE OXIDE (ODD-M) TO ELIMINATE OR PREVENT ACNE.
MX356551B (en) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Antiseptic, antiseborrheic, exfoliating composition for getting rid of or preventing acne.
CA2819967C (en) 2012-08-31 2016-03-22 Intermune, Inc. Use of pirfenidone concomitantly with ciprofloxacin
EP2903988A1 (en) 2012-10-08 2015-08-12 AbbVie Inc. Compounds useful for making hcv protease inhibitors
EA025560B1 (en) 2012-10-19 2017-01-30 Бристол-Майерс Сквибб Компани Hepatitis c virus inhibitors
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
JP2016501848A (en) * 2012-11-16 2016-01-21 アデレード リサーチ アンド イノヴェーション プロプライエタリー リミテッド Macrocyclic compounds and uses thereof
PT2950786T (en) 2013-01-31 2020-03-03 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
WO2014137869A1 (en) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
CA2905433A1 (en) 2013-03-14 2014-09-25 Achillion Pharmaceuticals, Inc. Novel processes for producing sovaprevir
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
US9085607B2 (en) 2013-03-15 2015-07-21 Achillion Pharmaceuticals, Inc. ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof
WO2014145507A1 (en) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. A process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
BR112015023351A2 (en) 2013-03-15 2017-07-18 Achillion Pharmaceuticals Inc crystalline form of sovaprevir, pharmaceutical composition, and method for treating a disorder
EA201690473A1 (en) 2013-08-27 2017-03-31 ГАЙЛИД ФАРМАССЕТ ЭлЭлСи COMBINED COMPOSITION OF TWO ANTI-VIRUS COMPOUNDS
EP3046924A1 (en) 2013-09-20 2016-07-27 IDENIX Pharmaceuticals, Inc. Hepatitis c virus inhibitors
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
NZ760541A (en) 2014-01-10 2022-08-26 Avalyn Pharma Inc Aerosol pirfenidone and pyridone analog compounds and uses thereof
US20170135990A1 (en) 2014-03-05 2017-05-18 Idenix Pharmaceuticals Llc Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
HUE061448T2 (en) 2014-11-16 2023-07-28 Array Biopharma Inc (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidin- Crystalline form of 1-carboxamide hydrogen sulfate
CN108697708A (en) 2015-10-26 2018-10-23 洛克索肿瘤学股份有限公司 Point mutation in TRK inhibitor resistant cancers and method related to this
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
ES2987474T3 (en) 2016-04-04 2024-11-15 Loxo Oncology Inc Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
ES2836222T3 (en) 2016-05-18 2021-06-24 Loxo Oncology Inc Preparation of (S) -N- (5 - ((R) -2- (2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1,5-a] pyrimidin-3-yl) -3-hydroxypyrrolidine- 1-carboxamide
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
CN108299506A (en) * 2018-01-29 2018-07-20 中国科学院成都有机化学有限公司 N- heterocycle carbine ruthenium complexs and its preparation method and application
GB201818750D0 (en) * 2018-11-16 2019-01-02 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
CN110041262B (en) 2019-01-02 2020-03-27 成都开美思商务信息咨询中心(有限合伙) Azacyclic carbene ligand and its ruthenium catalyst, preparation method and application
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors
BR112023027282A2 (en) 2021-06-23 2024-03-12 Orion Corp PROCESSES FOR PREPARING CYP11A1 INHIBITOR COMPOUNDS AND INTERMEDIATE COMPOUNDS THEREOF

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059929A1 (en) * 1999-04-06 2000-10-12 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
WO2005010029A1 (en) * 2003-07-03 2005-02-03 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis c serine protease inhibitors
WO2005037214A2 (en) * 2003-10-14 2005-04-28 Intermune, Inc. Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547119A (en) 1967-12-08 1970-12-15 Baxter Laboratories Inc Catheter assembly
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
US4211771A (en) 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US4311137A (en) 1980-04-30 1982-01-19 Sherwood Medical Industries Inc. Infusion device
US4531937A (en) 1983-01-24 1985-07-30 Pacesetter Systems, Inc. Introducer catheter apparatus and method of use
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
ATE108794T1 (en) 1985-05-15 1994-08-15 Wellcome Found THERAPEUTIC NUCLEOSIDES AND THEIR PRODUCTION.
US4806347A (en) 1985-12-11 1989-02-21 Schering Corporation Interferon combinations
US4755173A (en) 1986-02-25 1988-07-05 Pacesetter Infusion, Ltd. Soft cannula subcutaneous injection set
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5082659A (en) 1986-10-06 1992-01-21 Board Of Regents, The University Of Texas System Methods and compositions employing interferon-gamma
US5190751A (en) 1987-01-20 1993-03-02 Schering Corporation Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
ATE74517T1 (en) 1987-01-20 1992-04-15 Schering Corp TREATMENT OF SOME LEUKEMIAS WITH A COMPOSITION OF INTERFERON-GAMMA AND INTERFERON-ALPHA.
WO1988009673A1 (en) 1987-06-02 1988-12-15 Schering Corporation Treatment of chronic type b hepatitis with a combination of recombinant human alpha and gamma interferons
US5130421A (en) 1988-03-24 1992-07-14 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US4904770A (en) 1988-03-24 1990-02-27 Bristol-Myers Company Production of 2',3'-dideoxy-2',3'-didehydronucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US5552558A (en) 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5232928A (en) * 1989-07-25 1993-08-03 Boehringer Ingelheim Pharmaceuticals, Inc. Tetrahydroisoquinoline amides
GB8918806D0 (en) 1989-08-17 1989-09-27 Shell Int Research Chiral compounds,their preparation and use
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US5518729A (en) 1989-11-22 1996-05-21 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5716632A (en) 1989-11-22 1998-02-10 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
DE4121214A1 (en) 1991-06-27 1993-01-14 Bayer Ag 7-AZAISOINDOLINYL CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
US5610054A (en) 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
EP1302468B1 (en) 1992-12-29 2008-12-17 Abbott Laboratories Processes and intermediates for manufacturing retroviral protease inhibiting compounds
US5545143A (en) 1993-01-21 1996-08-13 T. S. I. Medical Device for subcutaneous medication delivery
KR960705579A (en) 1993-11-10 1996-11-08 에릭에스. 딕커 Improved interferon polymer conjugates
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US6693072B2 (en) * 1994-06-02 2004-02-17 Aventis Pharmaceuticals Inc. Elastase inhibitors
US5500208A (en) 1994-06-07 1996-03-19 The Procter & Gamble Company Oral compositions comprising a novel tripeptide
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
IL116730A0 (en) 1995-01-13 1996-05-14 Amgen Inc Chemically modified interferon
US6090822A (en) 1995-03-03 2000-07-18 Margolin; Solomon B. Treatment of cytokine growth factor caused disorders
GB9517022D0 (en) 1995-08-19 1995-10-25 Glaxo Group Ltd Medicaments
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5980884A (en) 1996-02-05 1999-11-09 Amgen, Inc. Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
US5908121A (en) 1996-03-11 1999-06-01 Dardashti; Shahriar Adjustable display assembly
US5633388A (en) 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
EP0907659A1 (en) 1996-05-10 1999-04-14 Schering Corporation Synthetic inhibitors of hepatitis c virus ns3 protease
AP1019A (en) 1996-10-18 2001-10-16 Vertex Pharma Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease.
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
AU7127298A (en) 1997-04-14 1998-11-11 Emory University Serine protease inhibitors
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
EP1012180B1 (en) 1997-08-11 2004-12-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor peptide analogues
US6767991B1 (en) * 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
ES2241157T3 (en) 1997-08-11 2005-10-16 Boehringer Ingelheim (Canada) Ltd. INHIBITING PEPTIDES OF HEPATITIS C.
US6172046B1 (en) 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
IT1299134B1 (en) 1998-02-02 2000-02-29 Angeletti P Ist Richerche Bio PROCEDURE FOR THE PRODUCTION OF PEPTIDES WITH PROTEAS INHIBITING THE NS3 PROTEASIS OF THE HCV VIRUS, PEPTIDES SO OBTAINABLE AND PEPTIDES
DK1066247T3 (en) 1998-03-31 2007-04-02 Vertex Pharma Inhibitors of serine proteases, especially hepatitis C virus NS3 protease
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
AR022061A1 (en) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd INHIBITING PEPTIDES OF HEPATITIS C, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, THE USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION, THE USE OF AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF THESE PEPTIDES AND A PROCEDURE FOR THE PREPARATION OF ANOGRAPH .
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6277830B1 (en) 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
WO2000066623A2 (en) 1999-05-04 2000-11-09 Boehringer Ingelheim (Canada) Ltd. Surrogate cell-based system and method for assaying the activity of hepatitis c virus ns3 protease
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
AU2001251165A1 (en) 2000-04-03 2001-10-15 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
ES2317900T3 (en) * 2000-04-05 2009-05-01 Schering Corporation SERINA PROTEASA NS3 MACROCICLIC INHIBITORS OF HEPATITIS C VIRUSES INCLUDING P2 N-CYCLICAL FRAGMENTS.
AU2001253621A1 (en) * 2000-04-19 2001-11-07 Schering Corporation Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
CN1498224A (en) * 2000-07-21 2004-05-19 ���鹫˾ Novel peptides as inhibitors of hepatitis C virus NS 3-serine protease
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
ES2263687T3 (en) * 2000-11-20 2006-12-16 Bristol-Myers Squibb Company TRIPEPTIDIC INHIBITORS OF HEPATITIS C.
CA2446380A1 (en) * 2001-05-08 2002-11-14 Yale University Proteomimetic compounds and methods
IL159087A0 (en) * 2001-07-11 2004-05-12 Vertex Pharma Bridged bicyclic compounds and pharmaceutical compositions containing the same
US6867185B2 (en) * 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
CA2369711A1 (en) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
US7119072B2 (en) 2002-01-30 2006-10-10 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis C virus
CA2370396A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US7091184B2 (en) 2002-02-01 2006-08-15 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor tri-peptides
CA2370400A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US6642204B2 (en) 2002-02-01 2003-11-04 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor tri-peptides
CA2369970A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US6828301B2 (en) 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
AU2003223602B8 (en) 2002-04-11 2010-05-27 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4 protease
AU2003231765B9 (en) * 2002-04-26 2010-01-28 Gilead Sciences, Inc. Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
US20040033970A1 (en) 2002-04-30 2004-02-19 Clark Richard F. Antibacterial compounds with improved pharmacokinetic profiles
DE60324552D1 (en) * 2002-05-20 2008-12-18 Bristol Myers Squibb Co Substituierte cycloalkyl p1' hepatitis c virus inhibitoren
ATE481106T1 (en) * 2002-05-20 2010-10-15 Bristol Myers Squibb Co HETEROCYCLIC SULFONAMIDE HEPATITIS C VIRUS INHIBITORS
ES2361011T3 (en) * 2002-05-20 2011-06-13 Bristol-Myers Squibb Company HEPATITIS VIRUS INHIBITORS C.
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US20040033959A1 (en) 2002-07-19 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20040138109A1 (en) * 2002-09-30 2004-07-15 Boehringer Ingelheim Pharmaceuticals, Inc. Potent inhibitor of HCV serine protease
PL199412B1 (en) * 2002-10-15 2008-09-30 Boehringer Ingelheim Int Ruthenium new complexes as (pre) catalytic agents of permutation reaction, new derivatives of 2-alkoxy-5-nitrostyrene as intermediate compounds and method of their receiving
US20050075279A1 (en) * 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7601709B2 (en) * 2003-02-07 2009-10-13 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
CA2515216A1 (en) 2003-02-07 2004-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis c serine protease inhibitors
US20040180815A1 (en) 2003-03-07 2004-09-16 Suanne Nakajima Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
WO2004101605A1 (en) * 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Hepatitis c inhibiting compounds
UY28240A1 (en) 2003-03-27 2004-11-08 Boehringer Ingelheim Pharma CRYSTAL PHASES OF A POWERFUL HCV INHIBITOR
MXPA05010338A (en) * 2003-04-02 2005-11-17 Boehringer Ingelheim Int Pharmaceutical compositions for hepatitis c viral protease inhibitors.
CA2521835A1 (en) 2003-04-10 2004-10-21 Boehringer Ingelheim International Gmbh Process for the preparation of macrocyclic compounds by ruthenium complex catalysed metathesis reaction
JP4231524B2 (en) * 2003-04-10 2009-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Process for producing macrocyclic compounds
WO2004092161A1 (en) * 2003-04-11 2004-10-28 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
ES2320771T3 (en) 2003-04-16 2009-05-28 Bristol-Myers Squibb Company PEPTIDIC INHIBITORS OF MACROCICLIC ISOQUINOLINE VIRUS OF HEPATITIS C.
US7176208B2 (en) * 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
CN1788006A (en) * 2003-04-18 2006-06-14 安南塔制药公司 Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
EP2359833A1 (en) 2003-04-25 2011-08-24 Gilead Sciences, Inc. Antiviral phosphonate analogs
US20040229848A1 (en) 2003-05-05 2004-11-18 Hans-Ulrich Demuth Glutaminyl based DP IV-inhibitors
US7273851B2 (en) 2003-06-05 2007-09-25 Enanta Pharmaceuticals, Inc. Tri-peptide hepatitis C serine protease inhibitors
UY28500A1 (en) 2003-09-05 2005-04-29 Vertex Pharma INHIBITORS OF SERINE PROTEASES, IN PARTICULAR PROTEASA NS3-NS4A HCV.
WO2005028502A1 (en) * 2003-09-18 2005-03-31 Vertex Pharmaceuticals, Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
RS20060197A (en) * 2003-09-22 2008-09-29 Boehringer Ingelheim International Gmbh., Macrocyclic peptides active against the hepatitis c virus
JP4525982B2 (en) * 2003-09-26 2010-08-18 シェーリング コーポレイション Macrocyclic inhibitor of NS3 serine protease of hepatitis C virus
WO2005037860A2 (en) * 2003-10-10 2005-04-28 Vertex Pharmaceuticals Incoporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
US7491794B2 (en) * 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
CN1894276B (en) * 2003-10-27 2010-06-16 威特克斯医药股份有限公司 HCV NS3-NS4A protease-resistant mutants
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
JP2007532479A (en) * 2003-11-20 2007-11-15 シェーリング　コーポレイション Depeptideization inhibitor of hepatitis C virus NS3 protease
US7135462B2 (en) 2003-11-20 2006-11-14 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7309708B2 (en) * 2003-11-20 2007-12-18 Birstol-Myers Squibb Company Hepatitis C virus inhibitors
CA2539575C (en) * 2003-11-20 2015-01-20 Boehringer Ingelheim International Gmbh Method of removing transition metals, especially from metathesis reaction products
ES2320776T3 (en) 2003-12-08 2009-05-28 Boehringer Ingelheim International Gmbh ELIMINATION OF RUTENIO SUBPRODUCTS BY TREATMENT WITH SUPERCRITICAL FLUIDS.
BRPI0416902A (en) * 2003-12-11 2007-01-16 Schering Corp hepatitis c virus ns3 / ns4a serine protease inhibitors
EP1730167B1 (en) 2004-01-21 2011-01-12 Boehringer Ingelheim International GmbH Macrocyclic peptides active against the hepatitis c virus
CA2544886C (en) 2004-01-28 2012-12-04 Boehringer Ingelheim International Gmbh Method of removing transition metals from reaction solutions comprising transition metal byproducts
PL1713822T3 (en) * 2004-01-30 2010-08-31 Medivir Ab Hcv ns-3 serine protease inhibitors
WO2005077969A2 (en) 2004-02-04 2005-08-25 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
EP1730165A1 (en) * 2004-02-27 2006-12-13 Schering Corporation Inhibitors of hepatitis c virus ns3 protease
US7816326B2 (en) * 2004-02-27 2010-10-19 Schering Corporation Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
AU2005219824B2 (en) * 2004-02-27 2007-11-29 Merck Sharp & Dohme Corp. Novel ketoamides with cyclic p4's as inhibitors of ns3 serine protease of hepatitis c virus
EP1737881B1 (en) * 2004-02-27 2009-06-24 Schering Corporation Novel compounds as inhibitors of hepatitis c virus ns3 serine protease
DE602005015834D1 (en) 2004-02-27 2009-09-17 Schering Corp 3,4- (CYCLOPENTYL) CONDENSED PROLIN LINES AS INHIBITORS OF THE NS3 SERINE PROTEASE OF HEPATITIS C VIRUS
WO2005090383A2 (en) 2004-03-15 2005-09-29 Boehringer Ingelheim International, Gmbh Process for preparing macrocyclic dipeptides which are suitable for the treatment of hepatitis c viral infections
BRPI0509467A (en) 2004-03-30 2007-09-11 Intermune Inc macrocyclic compounds as viral replication inhibitors
WO2005097820A1 (en) 2004-04-06 2005-10-20 Korea Research Institute Of Bioscience And Biotechnology Peptides for inhibiting mdm2 function
DE602005015452D1 (en) * 2004-05-20 2009-08-27 Schering Corp SUBSTITUTED PROLINE AS INHIBITOR OF NS3 SERINE PROTEASE OF HEPATITE C VIRUS
EP1753775B1 (en) 2004-05-25 2012-12-26 Boehringer Ingelheim International GmbH Process for preparing acyclic hcv protease inhibitors
EP1763531A4 (en) 2004-06-28 2009-07-01 Boehringer Ingelheim Int PEPTIDE ANALOGUES OF HEPATITIS C INHIBITORS
US7939538B2 (en) * 2004-06-28 2011-05-10 Amgen Inc. Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
DE102004033312A1 (en) * 2004-07-08 2006-01-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Continuous metathesis process with ruthenium catalysts
RS51974B (en) * 2004-07-16 2012-02-29 Gilead Sciences Inc. ANTI-VIRUS UNITS
JP4914355B2 (en) * 2004-07-20 2012-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Hepatitis C inhibitor peptide analog
UY29016A1 (en) 2004-07-20 2006-02-24 Boehringer Ingelheim Int ANALOGS OF INHIBITING DIPEPTIDES OF HEPATITIS C
CA2577812A1 (en) * 2004-08-27 2006-03-09 Schering Corporation Acylsulfonamide compounds as inhibitors of hepatitis c virus ns3 serine protease
US7375218B2 (en) 2004-09-17 2008-05-20 Boehringer Ingelheim International Gmbh Process for preparing macrocyclic HCV protease inhibitors
EP1794179A1 (en) * 2004-09-17 2007-06-13 Boehringer Ingelheim International Gmbh Ring-closing metathesis process in supercritical fluid
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
DE102005002336A1 (en) 2005-01-17 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for conducting continuous olefin-ring closure metathesis in compressed carbon dioxide
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
AU2006220887B2 (en) 2005-03-04 2010-11-04 The Rockefeller University Infectious, chimeric Hepatitis C Virus, methods of producing the same and methods of use thereof
AU2006220708B9 (en) 2005-03-08 2013-01-17 Boehringer Ingelheim International Gmbh Process for preparing macrocyclic compounds
WO2006113942A2 (en) 2005-04-20 2006-10-26 Schering Corporation Method of inhibiting cathepsin activity
CA2606195C (en) * 2005-05-02 2015-03-31 Merck And Co., Inc. Hcv ns3 protease inhibitors
MX2007014889A (en) 2005-05-26 2008-02-19 Schering Corp Interferon-igg fusion.
NZ563365A (en) 2005-06-02 2011-02-25 Schering Corp Combination of HCV protease inhibitors with a surfactant
US20060275366A1 (en) 2005-06-02 2006-12-07 Schering Corporation Controlled-release formulation
NZ563361A (en) 2005-06-02 2011-02-25 Schering Corp HCV protease inhibitors in combination with food
US20060276405A1 (en) 2005-06-02 2006-12-07 Schering Corporation Methods for treating hepatitis C
US20060281689A1 (en) 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
US20060287248A1 (en) 2005-06-02 2006-12-21 Schering Corporation Asymmetric dosing methods
US20070021351A1 (en) 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
US20070004635A1 (en) 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
WO2006130554A2 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
US20060276404A1 (en) 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
US7608592B2 (en) * 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
US7601686B2 (en) * 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI389908B (en) * 2005-07-14 2013-03-21 Gilead Sciences Inc Antiviral compounds
TW200738742A (en) 2005-07-14 2007-10-16 Gilead Sciences Inc Antiviral compounds
AR057456A1 (en) 2005-07-20 2007-12-05 Merck & Co Inc HCV PROTEASA NS3 INHIBITORS
AU2006276246B2 (en) 2005-07-25 2012-09-27 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis C virus replication
EP1915382A2 (en) 2005-08-01 2008-04-30 Phenomix Corporation Hepatitis c serine protease inhibitors and uses therefor
AU2006275413B2 (en) 2005-08-02 2012-07-19 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (en) 2005-08-26 2007-08-22 Vertex Pharma INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
ES2356776T3 (en) * 2005-10-11 2011-04-13 Intermune, Inc. COMPOUNDS AND METHODS TO INHIBIT THE REPLICATION OF THE HEPATITIS VIRUS.
US7772183B2 (en) * 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7705138B2 (en) * 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
EP1981524A2 (en) 2006-02-09 2008-10-22 Schering Corporation Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto
WO2007109080A2 (en) 2006-03-16 2007-09-27 Vertex Pharmaceuticals Incorporated Deuterated hepatitis c protease inhibitors
WO2007111866A2 (en) 2006-03-23 2007-10-04 Schering Corporation Combinations of hcv protease inhibitor(s) and cyp3a4 inhibitor(s), and methods of treatment related thereto
AU2007249668B2 (en) 2006-04-11 2011-04-07 Novartis Ag HCV/HIV inhibitors and their uses
US20080187516A1 (en) 2006-06-06 2008-08-07 Ying Sun Acyclic oximyl hepatitis c protease inhibitors
US7728148B2 (en) * 2006-06-06 2010-06-01 Enanta Pharmaceuticals, Inc. Acyclic oximyl hepatitis C protease inhibitors
US9526769B2 (en) 2006-06-06 2016-12-27 Enanta Pharmaceuticals, Inc. Macrocylic oximyl hepatitis C protease inhibitors
US20090203008A1 (en) 2006-06-08 2009-08-13 Ludmerer Steven W Rapid method to determine inhibitor sensitivity of NS3/4A protease sequences cloned from clinical samples
AR061629A1 (en) 2006-06-26 2008-09-10 Enanta Pharm Inc QUINOXALINIL MACROCICLIC INHIBITORS OF SERINE PROTEASE OF HEPATITIS VIRUS C. PROCESS OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS
RU2008152171A (en) * 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) NEW HEPATITIS C VIRAL REPLICATION INHIBITORS
US7935670B2 (en) * 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2041156E (en) * 2006-07-13 2014-02-21 Achillion Pharmaceuticals Inc 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
SG174809A1 (en) * 2007-05-03 2011-10-28 Intermune Inc Macrocyclic compounds useful as inhibitors of hepatitis c virus
JP2010526834A (en) 2007-05-10 2010-08-05 インターミューン・インコーポレーテッド Novel peptide inhibitors of hepatitis C virus replication
WO2009142842A2 (en) 2008-04-15 2009-11-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
KR20110075019A (en) * 2008-10-15 2011-07-05 인터뮨, 인크. Therapeutic Antiviral Peptides
AR075584A1 (en) * 2009-02-27 2011-04-20 Intermune Inc THERAPEUTIC COMPOSITIONS THAT INCLUDE beta-D-2'-DESOXI-2'-FLUORO-2'-C-METHYLYCTIDINE AND A CARDIEX ISOINDOL ACID DERIVATIVE AND ITS USES. COMPOUND.
CN102741270B (en) * 2009-09-28 2015-07-22 英特穆恩公司 Cyclic peptide inhibitors of hepatitis C virus replication
MX2012003171A (en) * 2009-09-28 2012-04-11 Hoffmann La Roche Novel macrocyclic inhibitors of hepatitis c virus replication.
US20110082182A1 (en) * 2009-10-01 2011-04-07 Intermune, Inc. Therapeutic antiviral peptides
US20110312996A1 (en) 2010-05-17 2011-12-22 Intermune, Inc. Novel inhibitors of hepatitis c virus replication

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059929A1 (en) * 1999-04-06 2000-10-12 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
WO2005010029A1 (en) * 2003-07-03 2005-02-03 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis c serine protease inhibitors
WO2005037214A2 (en) * 2003-10-14 2005-04-28 Intermune, Inc. Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEAULIEU P L ET AL: "Synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid vinyl-ACCA derivatives: Key intermediates for the preparation of inhibitors of the hepatitis C virus NS3 protease", JOURNAL OF ORGANIC CHEMISTRY 22 JUL 2005 UNITED STATES, vol. 70, no. 15, 22 July 2005 (2005-07-22), pages 5869 - 5879, XP002415438, ISSN: 0022-3263 *
BELOKON Y N ET AL: "GENERAL METHOD FOR THE ASYMMETRIC SYNTHESIS OF ANTI-DIASTEREOISOMERS OF BETA SUBSTITUTED L-2 AMINOBUTANOIC ACIDS VIA CHIRAL NICKEL-II SCHIFF'S BASE COMPLEXES OF DEHYDROAMINOBUTANOIC ACID X-RAY CRYSTAL AND MOLECULAR STRUCTURE OF THE NICKEL-II", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 8, 1990, pages 2301 - 2310, XP008072303, ISSN: 0300-922X *
GALGOCI M ET AL: "A convenient synthesis of methyl (Z)-1-carbamoyl-2-ethenylcyclopropan ecarboxylate and (Z)-1-carbamoyl-2-ethenylcyclopropanecarboxylic acid", SYNTHETIC COMMUNICATIONS 1994 UNITED STATES, vol. 24, no. 17, 1994, pages 2477 - 2483, XP008072283, ISSN: 0039-7911 *
TSANTRIZOS Y S ET AL: "Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, DE, vol. 42, no. 12, 28 March 2003 (2003-03-28), pages 1356 - 1360, XP002278992, ISSN: 1433-7851 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889871B2 (en) 2002-05-20 2014-11-18 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9227940B2 (en) 2002-05-20 2016-01-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
US8957046B2 (en) 2007-03-30 2015-02-17 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9585906B2 (en) 2007-03-30 2017-03-07 Gilead Pharmasset Llc Nucleoside phosphoramidate prodrugs
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9527885B2 (en) 2011-05-05 2016-12-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9549941B2 (en) 2011-11-29 2017-01-24 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9296782B2 (en) 2012-07-03 2016-03-29 Gilead Sciences, Inc. Inhibitors of hepatitis C virus
US9617310B2 (en) 2013-03-15 2017-04-11 Gilead Sciences, Inc. Inhibitors of hepatitis C virus

Also Published As

Publication number Publication date
CU23794B7 (en) 2012-03-15
EA015752B1 (en) 2011-12-30
JP2009502920A (en) 2009-01-29
IL188693A (en) 2012-08-30
IL221361A (en) 2013-07-31
EP2305698A2 (en) 2011-04-06
EP2305696A2 (en) 2011-04-06
KR101294467B1 (en) 2013-09-09
EA200800413A1 (en) 2008-10-30
CN102816170A (en) 2012-12-12
CA2615666C (en) 2014-08-26
US20070054842A1 (en) 2007-03-08
JP5249028B2 (en) 2013-07-31
CA2615666A1 (en) 2007-02-08
WO2007015824A2 (en) 2007-02-08
IL188693A0 (en) 2008-08-07
EP1924594A2 (en) 2008-05-28
EP2305697A2 (en) 2011-04-06
US8299021B2 (en) 2012-10-30
US20120208995A1 (en) 2012-08-16
AU2006276246A1 (en) 2007-02-08
JP2012214476A (en) 2012-11-08
AR055095A1 (en) 2007-08-08
MX2008001166A (en) 2008-03-18
AU2006276246B2 (en) 2012-09-27
US20090148407A1 (en) 2009-06-11
EP2305698A3 (en) 2011-07-27
BRPI0613962A2 (en) 2009-03-24
EP2103623A3 (en) 2009-12-16
SG166791A1 (en) 2010-12-29
CU20080010A7 (en) 2011-03-21
KR20080039434A (en) 2008-05-07
NO20080875L (en) 2008-04-08
MA29746B1 (en) 2008-09-01
US7829665B2 (en) 2010-11-09
ECSP088208A (en) 2008-03-26
GEP20105124B (en) 2010-11-25
NZ565059A (en) 2011-08-26
EA019888B1 (en) 2014-07-30
EA201170969A1 (en) 2012-03-30
US20090169510A1 (en) 2009-07-02
CN101263156A (en) 2008-09-10
TNSN08022A1 (en) 2009-07-14
MY148690A (en) 2013-05-31
EP2305696A3 (en) 2011-10-12
EP2103623A2 (en) 2009-09-23
EP2305697A3 (en) 2011-07-27
TW200740851A (en) 2007-11-01
EP2305695A3 (en) 2011-07-27
IL221361A0 (en) 2012-09-24
NZ594105A (en) 2013-02-22
EP2305695A2 (en) 2011-04-06

Similar Documents

Publication Publication Date Title
WO2007015824A3 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
WO2008137779A3 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
WO2008005511A8 (en) Novel inhibitors of hepatitis c virus replication
WO2007047146A3 (en) Inhibitors of viral replication
WO2009142842A3 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
TN2009000481A1 (en) Novel peptide inhibitors of hepatitis c virus replication
WO2008100867A3 (en) Novel inhibitors hepatitis c virus replication
WO2005095403A3 (en) Macrocyclic compounds as inhibitors of viral replication
WO2009134616A8 (en) Novel inhibitors of hepatitis c virus replication
MX2012003171A (en) Novel macrocyclic inhibitors of hepatitis c virus replication.
WO2012087976A3 (en) Novel inhibitors of hepatitis c virus replication
WO2005037214A3 (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
WO2008106058A3 (en) Inhibitors of serine proteases
WO2006039488A3 (en) Hcv ns3-ns4a protease inhibition
WO2008021927A3 (en) Hepatitis c virus inhibitors
UA91677C2 (en) Macrocyclic compounds as inhibitors of hcv replication
UA95455C2 (en) Macrocyclic inhibitors of hepatitis c virus replication
TNSN06103A1 (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication
TW200611905A (en) Macrocyclic compounds as inhibitors of viral replication
TN2010000468A1 (en) Novel macrocyclic inhibitors of hepatitis c virus replication
UA84579C2 (en) Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hepatitis c virus replication

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680027290.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 188693

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 565059

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2615666

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 12008500128

Country of ref document: PH

WWE Wipo information: entry into national phase

Ref document number: AP/P/2008/004312

Country of ref document: AP

WWE Wipo information: entry into national phase

Ref document number: 2008010115

Country of ref document: EG

WWE Wipo information: entry into national phase

Ref document number: MX/a/2008/001166

Country of ref document: MX

Ref document number: 2008523949

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: DZP2008000043

Country of ref document: DZ

WWE Wipo information: entry into national phase

Ref document number: 08015831

Country of ref document: CO

WWE Wipo information: entry into national phase

Ref document number: 2006276246

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1510/DELNP/2008

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 1020087004379

Country of ref document: KR

Ref document number: 200800413

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 10529

Country of ref document: GE

Ref document number: a200802340

Country of ref document: UA

Ref document number: 2006800088

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006276246

Country of ref document: AU

Date of ref document: 20060717

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 11996902

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0613962

Country of ref document: BR

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 221361

Country of ref document: IL