WO2007024826A3 - Method of storing nanoparticle formulations - Google Patents

Method of storing nanoparticle formulations Download PDF

Info

Publication number
WO2007024826A3
WO2007024826A3 PCT/US2006/032714 US2006032714W WO2007024826A3 WO 2007024826 A3 WO2007024826 A3 WO 2007024826A3 US 2006032714 W US2006032714 W US 2006032714W WO 2007024826 A3 WO2007024826 A3 WO 2007024826A3
Authority
WO
WIPO (PCT)
Prior art keywords
storing
nanoparticle formulations
storing nanoparticle
formulation
incldes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/032714
Other languages
French (fr)
Other versions
WO2007024826A2 (en
Inventor
Weiping Yu
John Mon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imunon Inc
Original Assignee
Celsion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celsion Corp filed Critical Celsion Corp
Priority to EP06789920.3A priority Critical patent/EP1937214B1/en
Priority to CN2006800312295A priority patent/CN101282715B/en
Priority to ES06789920.3T priority patent/ES2587583T3/en
Priority to HK08112480.4A priority patent/HK1120731B/en
Priority to JP2008528056A priority patent/JP5227173B2/en
Priority to CA2620829A priority patent/CA2620829C/en
Priority to AU2006283465A priority patent/AU2006283465B2/en
Publication of WO2007024826A2 publication Critical patent/WO2007024826A2/en
Publication of WO2007024826A3 publication Critical patent/WO2007024826A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

The present invention is a method for storing a liposome or nanoparticle formulation formed by the combination of at least one phospholipid, at least one sufactant and at least one hydrophilic polymer. The method incldes freezing such a formulation, and storing it for a period of at least three days.
PCT/US2006/032714 2005-08-23 2006-08-23 Method of storing nanoparticle formulations Ceased WO2007024826A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP06789920.3A EP1937214B1 (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations
CN2006800312295A CN101282715B (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations
ES06789920.3T ES2587583T3 (en) 2005-08-23 2006-08-23 Storage method of nanoparticle formulations
HK08112480.4A HK1120731B (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations
JP2008528056A JP5227173B2 (en) 2005-08-23 2006-08-23 Storage method for nanoparticle formulations
CA2620829A CA2620829C (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations
AU2006283465A AU2006283465B2 (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71015605P 2005-08-23 2005-08-23
US60/710,156 2005-08-23

Publications (2)

Publication Number Publication Date
WO2007024826A2 WO2007024826A2 (en) 2007-03-01
WO2007024826A3 true WO2007024826A3 (en) 2007-10-11

Family

ID=37441856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032714 Ceased WO2007024826A2 (en) 2005-08-23 2006-08-23 Method of storing nanoparticle formulations

Country Status (9)

Country Link
EP (1) EP1937214B1 (en)
JP (1) JP5227173B2 (en)
KR (2) KR101209496B1 (en)
CN (1) CN101282715B (en)
AU (1) AU2006283465B2 (en)
CA (1) CA2620829C (en)
ES (1) ES2587583T3 (en)
TW (1) TWI388344B (en)
WO (1) WO2007024826A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090122479A (en) * 2007-03-30 2009-11-30 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Encapsulation of Hydrophobic Quantum Dots
WO2009059449A1 (en) 2007-11-05 2009-05-14 Celsion Corporation Novel thermosensitive liposomes containing therapeutic agents
JP2015507019A (en) * 2012-02-17 2015-03-05 セルシオン コーポレイション Thermosensitive nanoparticle preparation and method for producing the same
US11679163B2 (en) 2019-09-20 2023-06-20 Hdt Bio Corp. Compositions and methods for delivery of RNA
CA3172489A1 (en) 2020-03-23 2021-09-30 Amit KHANDHAR Nanoemulsion compositions and methods for delivery of nra
EP4404919A4 (en) * 2021-09-22 2025-08-20 Hdt Bio Corp DRIED NANOPARTICLE COMPOSITIONS
JP2024535354A (en) 2021-09-22 2024-09-30 エイチディーティー バイオ コーポレーション Cancer treatment compositions and uses thereof
EP4405372A4 (en) 2021-09-22 2026-01-14 Hdt Bio Corp SARS-CoV-2 RNA vaccine compositions and methods of use
KR20240096468A (en) 2021-09-22 2024-06-26 에이치디티 바이오 코포레이션 RNA vaccines against infectious diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065466A1 (en) * 1998-06-18 1999-12-23 Duke University Temperature-sensitive liposomal formulation
WO2004019913A1 (en) * 2002-08-29 2004-03-11 Monte Verde S.A. A pharmaceutical composition of small-sized liposomes and method of preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256372A (en) * 1985-04-11 1989-06-27 Koichiro Miyazima Process for producing liposome composition
KR900700079A (en) * 1988-01-12 1990-08-11 후지하라 도미오 Leak-proof liposome formulation
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
JPH06211645A (en) * 1993-01-14 1994-08-02 Mitsubishi Kasei Corp Liposome freeze-dried preparation
EP0805678B1 (en) * 1995-01-05 2003-10-29 THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN Surface-modified nanoparticles and method of making and using same
ATE247971T1 (en) * 1995-08-01 2003-09-15 Novartis Erfind Verwalt Gmbh LIPOSOMAL OLIGONUCLEOTIDE COMPOSITIONS
GB9609779D0 (en) * 1996-05-10 1996-07-17 Univ Bruxelles Freeze dried liposome encapsulated amphiphilic drug compositions and a process for the preparation thereof
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
DE60014093T2 (en) * 1999-07-16 2005-02-03 Alza Corp., Mountain View Liposome composition with protection against freeze / build damage
JP4293586B2 (en) * 2002-08-30 2009-07-08 浜松ホトニクス株式会社 Nanoparticle production method and production apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999065466A1 (en) * 1998-06-18 1999-12-23 Duke University Temperature-sensitive liposomal formulation
WO2004019913A1 (en) * 2002-08-29 2004-03-11 Monte Verde S.A. A pharmaceutical composition of small-sized liposomes and method of preparation

Also Published As

Publication number Publication date
JP2009506038A (en) 2009-02-12
AU2006283465A1 (en) 2007-03-01
KR20080046672A (en) 2008-05-27
AU2006283465B2 (en) 2011-11-03
ES2587583T3 (en) 2016-10-25
WO2007024826A2 (en) 2007-03-01
CN101282715A (en) 2008-10-08
EP1937214A2 (en) 2008-07-02
JP5227173B2 (en) 2013-07-03
EP1937214B1 (en) 2016-07-27
CN101282715B (en) 2013-03-27
CA2620829A1 (en) 2007-03-01
TW200803918A (en) 2008-01-16
CA2620829C (en) 2013-10-29
HK1120731A1 (en) 2009-04-09
KR101209496B1 (en) 2012-12-07
TWI388344B (en) 2013-03-11
KR20120104438A (en) 2012-09-20

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