WO2007031277A3 - Means and methods for diagnosing endometriosis - Google Patents

Means and methods for diagnosing endometriosis Download PDF

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Publication number
WO2007031277A3
WO2007031277A3 PCT/EP2006/008877 EP2006008877W WO2007031277A3 WO 2007031277 A3 WO2007031277 A3 WO 2007031277A3 EP 2006008877 W EP2006008877 W EP 2006008877W WO 2007031277 A3 WO2007031277 A3 WO 2007031277A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
endometriosis
diagnosing endometriosis
molecules interacting
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/008877
Other languages
French (fr)
Other versions
WO2007031277A2 (en
Inventor
Walter Tschugguel
Cristina Rubiolo
Andrea Kolbus
Ljubomir Paucz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medizinische Universitaet Wien
Original Assignee
Medizinische Universitaet Wien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medizinische Universitaet Wien filed Critical Medizinische Universitaet Wien
Priority to EP06791999A priority Critical patent/EP1931993A2/en
Publication of WO2007031277A2 publication Critical patent/WO2007031277A2/en
Publication of WO2007031277A3 publication Critical patent/WO2007031277A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/364—Endometriosis, i.e. non-malignant disorder in which functioning endometrial tissue is present outside the uterine cavity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to means and methods for determining the likelihood of endometriosis in a female subject. Furthermore, kits for performing the inventive methods are provided. The invention also provides for novel uses of binding molecules interacting with and/or specifically binding to ezrin and/or of binding molecules interacting with and/or specifically binding to insulin receptor substrate-1 (IRS-1) in the preparation of diagnostic compositions for endometriosis.
PCT/EP2006/008877 2005-09-14 2006-09-12 Means and methods for diagnosing endometriosis Ceased WO2007031277A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06791999A EP1931993A2 (en) 2005-09-14 2006-09-12 Means and methods for diagnosing endometriosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ATA1519/2005 2005-09-14
AT15192005 2005-09-14
US83510506P 2006-08-03 2006-08-03
US60/835,105 2006-08-03

Publications (2)

Publication Number Publication Date
WO2007031277A2 WO2007031277A2 (en) 2007-03-22
WO2007031277A3 true WO2007031277A3 (en) 2007-06-21

Family

ID=37606092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/008877 Ceased WO2007031277A2 (en) 2005-09-14 2006-09-12 Means and methods for diagnosing endometriosis

Country Status (2)

Country Link
EP (1) EP1931993A2 (en)
WO (1) WO2007031277A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11287425B2 (en) 2009-04-22 2022-03-29 Juneau Biosciences, Llc Genetic markers associated with endometriosis and use thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009140126A1 (en) * 2008-05-14 2009-11-19 Juneau Biosciences, Llc Method of administering a therapeutic
DE102012002929A1 (en) * 2012-02-14 2013-08-14 Jürgen Lewald Analyzing a peripheral blood sample of a female subject based on concentration of a steroid hormone that indicates endometriosis, comprising e.g. testosterone, progesterone, cortisol, dehydroepiandrosterone and androstenedione
RU2675525C1 (en) * 2017-12-12 2018-12-19 Публичное акционерное общество "СИБУР Холдинг" Copolymers of coupped dienes and vinylaromatic monomers and method for their production; rubber mixtures based on the specified copolymers

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063116A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of prothymosin in the diagnosis and treatment of endometriosis
WO2000043789A1 (en) * 1999-01-25 2000-07-27 Procrea Biosciences Inc. Method and diagnostic kit for diagnosis of endometriosis
WO2004016739A2 (en) * 2002-08-01 2004-02-26 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Cell modulation using a cytoskeletal protein
US20040162257A1 (en) * 2001-06-14 2004-08-19 Gene Signal, A Corporation Of France Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
WO2006015079A2 (en) * 2004-07-27 2006-02-09 Yale University Erm family binding agents and their use in diagnosis and treatment of proliferative conditions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063116A2 (en) * 1998-06-04 1999-12-09 Reprogen, Inc. Use of prothymosin in the diagnosis and treatment of endometriosis
WO2000043789A1 (en) * 1999-01-25 2000-07-27 Procrea Biosciences Inc. Method and diagnostic kit for diagnosis of endometriosis
US20040162257A1 (en) * 2001-06-14 2004-08-19 Gene Signal, A Corporation Of France Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
WO2004016739A2 (en) * 2002-08-01 2004-02-26 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Cell modulation using a cytoskeletal protein
US20040105860A1 (en) * 2002-08-01 2004-06-03 Losordo Douglas W. Cell modulation using a cytoskeletal protein
WO2006015079A2 (en) * 2004-07-27 2006-02-09 Yale University Erm family binding agents and their use in diagnosis and treatment of proliferative conditions

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
COLOMBATTI ALFONSO ET AL: "Differential expression of IRS-1 and IRS-2 in uterine leiomyosarcomas with distinct oncogenic phenotypes: Lack of correlation with downstream signaling events.", SARCOMA, vol. 6, no. 3, September 2002 (2002-09-01), pages 89 - 96, XP002425254, ISSN: 1357-714X *
DATABASE Geneseq [online] 7 April 2003 (2003-04-07), "Amino acid sequence of human insulin receptor substrate-1.", XP002425283, retrieved from EBI accession no. GSP:ABB99797 Database accession no. ABB99797 *
DHEENADAYALU KAVITHA ET AL: "Aromatase P450 messenger RNA expression in eutopic endometrium is not a specific marker for pelvic endometriosis.", FERTILITY AND STERILITY OCT 2002, vol. 78, no. 4, October 2002 (2002-10-01), pages 825 - 829, XP002416051, ISSN: 0015-0282 *
HARRISON G M ET AL: "DISTRIBUTION AND EXPRESSION OF CD44 ISOFORMS AND EZRIN DURING PROSTATE CANCER-ENDOTHELIUM INTERACTION", INTERNATIONAL JOURNAL OF ONCOLOGY, EDITORIAL ACADEMY OF THE INTERNATIONAL JOURNAL OF ONCOLOGY,, GR, vol. 21, no. 5, November 2002 (2002-11-01), pages 935 - 940, XP009065619, ISSN: 1019-6439 *
NAGAMANI ET AL: "Specific binding and growth-promoting activity of insulin in endometrial cancer cells in culture", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 179, no. 1, July 1998 (1998-07-01), pages 6 - 12, XP005691528, ISSN: 0002-9378 *
OHTANI K ET AL: "Ezrin, a membrane-cytoskeletal linking protein, is highly expressed in atypical endometrial hyperplasia and uterine endometrioid adenocarcinoma", CANCER LETTERS, NEW YORK, NY, US, vol. 179, no. 1, 8 May 2002 (2002-05-08), pages 79 - 86, XP002378867, ISSN: 0304-3835 *
OHTANI K ET AL: "Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells", CANCER LETTERS, NEW YORK, NY, US, vol. 147, no. 1-2, 1 December 1999 (1999-12-01), pages 31 - 38, XP002378865, ISSN: 0304-3835 *
SURMACZ W ET AL: "OVEREXPRESSION OF INSULIN RECEPTON SUBSTRATE 1 (IRS-1) IN THE HUMAN BREAST CANCER CELL LINE MCF-7 INDUCES LOSS OF AND TRANSFORMATION 1", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 1, no. 11, 1 November 1995 (1995-11-01), pages 1429 - 1436, XP000560324, ISSN: 1078-0432 *
WU X ET AL: "Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls.", FERTILITY AND STERILITY SEP 2000, vol. 74, no. 3, September 2000 (2000-09-01), pages 564 - 572, XP002415873, ISSN: 0015-0282 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11287425B2 (en) 2009-04-22 2022-03-29 Juneau Biosciences, Llc Genetic markers associated with endometriosis and use thereof

Also Published As

Publication number Publication date
WO2007031277A2 (en) 2007-03-22
EP1931993A2 (en) 2008-06-18

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