WO2007047722A3 - Methods for treating disorders associated with hyperlipidemia in a mammal - Google Patents

Methods for treating disorders associated with hyperlipidemia in a mammal Download PDF

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Publication number
WO2007047722A3
WO2007047722A3 PCT/US2006/040637 US2006040637W WO2007047722A3 WO 2007047722 A3 WO2007047722 A3 WO 2007047722A3 US 2006040637 W US2006040637 W US 2006040637W WO 2007047722 A3 WO2007047722 A3 WO 2007047722A3
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WO
WIPO (PCT)
Prior art keywords
methods
inhibitor
mammal
mtp
hyperlipidemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/040637
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French (fr)
Other versions
WO2007047722A2 (en
Inventor
Gerald L Wisler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amryt Pharmaceuticals Inc
Original Assignee
Aegerion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aegerion Pharmaceuticals Inc filed Critical Aegerion Pharmaceuticals Inc
Priority to AU2006304531A priority Critical patent/AU2006304531A1/en
Priority to CA002626422A priority patent/CA2626422A1/en
Priority to JP2008536750A priority patent/JP2009511634A/en
Priority to EP06817090A priority patent/EP1948163A2/en
Publication of WO2007047722A2 publication Critical patent/WO2007047722A2/en
Publication of WO2007047722A3 publication Critical patent/WO2007047722A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
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  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention is directed to methods for treating hyperlipidemia in a mammal. The methods involve combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for example, BMS-201038 and implitade) and a cholesterol absorption inhibitor (CAI) (for example, ezetimibe). Co-administration of the MTP inhibitor with the CAI produces a therapeutic benefit, for example, a reduction in the concentration of cholesterol and/or triglycerides in the blood stream, but with fewer or reduced side effects than when higher dosages of the MTP inhibitor are used during monotherapy to provide the same or similar therapeutic benefit.
PCT/US2006/040637 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal Ceased WO2007047722A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2006304531A AU2006304531A1 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal
CA002626422A CA2626422A1 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal
JP2008536750A JP2009511634A (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in mammals
EP06817090A EP1948163A2 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72766405P 2005-10-18 2005-10-18
US60/727,664 2005-10-18
US78861606P 2006-04-03 2006-04-03
US60/788,616 2006-04-03

Publications (2)

Publication Number Publication Date
WO2007047722A2 WO2007047722A2 (en) 2007-04-26
WO2007047722A3 true WO2007047722A3 (en) 2007-08-02

Family

ID=37814399

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2006/040639 Ceased WO2007047724A2 (en) 2005-10-18 2006-10-18 Compositions for lowering serum cholesterol and/or triglycerides
PCT/US2006/040637 Ceased WO2007047722A2 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal
PCT/US2006/040953 Ceased WO2007047880A2 (en) 2005-10-18 2006-10-18 Compositions for lowering serum cholesterol and/or triglycerides
PCT/US2006/040640 Ceased WO2007047725A2 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040639 Ceased WO2007047724A2 (en) 2005-10-18 2006-10-18 Compositions for lowering serum cholesterol and/or triglycerides

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2006/040953 Ceased WO2007047880A2 (en) 2005-10-18 2006-10-18 Compositions for lowering serum cholesterol and/or triglycerides
PCT/US2006/040640 Ceased WO2007047725A2 (en) 2005-10-18 2006-10-18 Methods for treating disorders associated with hyperlipidemia in a mammal

Country Status (6)

Country Link
US (9) US20070093468A1 (en)
EP (4) EP1951220A2 (en)
JP (3) JP2009511634A (en)
AU (3) AU2006304689A1 (en)
CA (3) CA2626441A1 (en)
WO (4) WO2007047724A2 (en)

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KR101494067B1 (en) 2004-03-05 2015-02-16 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
US20130082232A1 (en) 2011-09-30 2013-04-04 Unity Semiconductor Corporation Multi Layered Conductive Metal Oxide Structures And Methods For Facilitating Enhanced Performance Characteristics Of Two Terminal Memory Cells
AU2006304689A1 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Compositions for lowering serum cholesterol and/or triglycerides
US20080103122A1 (en) * 2006-09-05 2008-05-01 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008072056A1 (en) * 2006-12-14 2008-06-19 Pfizer Limited Use of mtp inhibitors for the treatment of obesity using low doses and dose-escalation
JP2010513534A (en) * 2006-12-21 2010-04-30 エージェリオン ファーマシューティカルズ， インコーポレイテッド Method of treating obesity using a combination comprising an MTP inhibitor and a cholesterol absorption inhibitor
WO2008090198A1 (en) * 2007-01-25 2008-07-31 Janssen Pharmaceutica Nv Use of mtp inhibitors for increasing levels of satiety hormones
WO2010083280A2 (en) * 2009-01-14 2010-07-22 Aegerion Pharmaceuticals, Inc. Methods for treating obesity and disorders associated with hyperlipidemia in a mammal
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2010148179A1 (en) * 2009-06-18 2010-12-23 Japan Tobacco Inc. Method of treating a disorder associated with mtp
ES2384852B1 (en) 2010-12-17 2013-06-04 Fundació Imim HYDROXYTIROSOL ETHERS
BR102015025502B1 (en) * 2015-04-30 2022-06-21 Aegerion Pharmaceuticals, Inc Composition of lomitapide, tablet, lomitapide product, methods for analyzing a sample composition of lomitapide and for determining an amount of an impurity in a sample of the composition
WO2021052892A1 (en) * 2019-09-16 2021-03-25 F. Hoffmann-La Roche Ag Piperidinyl amine compounds for the treatment of autoimmune disease
CA3186856A1 (en) 2020-07-29 2022-02-03 Ruth NALLEN Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

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