WO2007054964A3 - Process for the preparation of letrozole - Google Patents

Process for the preparation of letrozole Download PDF

Info

Publication number
WO2007054964A3
WO2007054964A3 PCT/IN2006/000337 IN2006000337W WO2007054964A3 WO 2007054964 A3 WO2007054964 A3 WO 2007054964A3 IN 2006000337 W IN2006000337 W IN 2006000337W WO 2007054964 A3 WO2007054964 A3 WO 2007054964A3
Authority
WO
WIPO (PCT)
Prior art keywords
letrozole
preparation
regioisomer
impurities
solvents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2006/000337
Other languages
French (fr)
Other versions
WO2007054964A2 (en
Inventor
Hussain Haider
Kirtipalsinh Saijansin Solanki
Gautam Pal
Manoj Kumar Singh
Jay Shantilal Kothari
Virendra Kumar Agarwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Priority to US12/083,665 priority Critical patent/US20100190997A1/en
Priority to EP06842739A priority patent/EP1945618A2/en
Publication of WO2007054964A2 publication Critical patent/WO2007054964A2/en
Publication of WO2007054964A3 publication Critical patent/WO2007054964A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

The present invention relates to the process for the preparation of Letrozole free from its regioisomer (7) and other impurities by selective extraction of desired intermediate (3) using suitable solvent and mixture of solvents.
PCT/IN2006/000337 2005-10-20 2006-09-04 Process for the preparation of letrozole Ceased WO2007054964A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/083,665 US20100190997A1 (en) 2005-10-20 2006-09-04 Process for the Preparation of Letrozole
EP06842739A EP1945618A2 (en) 2005-10-20 2006-09-04 Process for the preparation of letrozole

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1315MU2005 2005-10-20
IN1315-MUM-2005 2005-10-20

Publications (2)

Publication Number Publication Date
WO2007054964A2 WO2007054964A2 (en) 2007-05-18
WO2007054964A3 true WO2007054964A3 (en) 2007-07-12

Family

ID=37944721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000337 Ceased WO2007054964A2 (en) 2005-10-20 2006-09-04 Process for the preparation of letrozole

Country Status (3)

Country Link
US (1) US20100190997A1 (en)
EP (1) EP1945618A2 (en)
WO (1) WO2007054964A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608904A1 (en) 2005-07-06 2007-09-07 Sicor Inc. Improved process for the preparation of letrozole
US7465749B2 (en) * 2005-11-14 2008-12-16 Chemagis, Ltd. Letrozole purification process
US8198460B2 (en) * 2007-11-28 2012-06-12 Fresenius Kabi Oncology Ltd. Process for preparation of letrozole and its intermediates
WO2011000396A1 (en) * 2009-07-02 2011-01-06 Synthon B.V. Purification of letrozole intermediate
RU2425038C2 (en) * 2009-11-27 2011-07-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Method of producing 1-[di (4-cyanophenyl)methyl]-1,2,4-triazole
WO2012025762A2 (en) 2010-08-27 2012-03-01 Generics [Uk] Limited Pure intermediate
WO2015029519A1 (en) * 2013-09-02 2015-03-05 株式会社クレハ Method for producing triazole compound
CN103664810B (en) * 2013-12-11 2016-09-14 深圳劲创生物技术有限公司 A kind of technique synthesizing letrozole
CN117924195A (en) * 2023-08-23 2024-04-26 中科帆凯(大连)新材料有限公司 Method for preparing pure letrozole intermediate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
WO2004076409A2 (en) * 2003-02-06 2004-09-10 Sun Pharmaceutical Industries Limited Regiospecific process for the preparation of 4-[1- (4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
WO2005047269A1 (en) * 2003-11-14 2005-05-26 Natco Pharma Limited A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
US20050209294A1 (en) * 2004-03-17 2005-09-22 Wadhwa Lalit K Process for producing 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
WO2004076409A2 (en) * 2003-02-06 2004-09-10 Sun Pharmaceutical Industries Limited Regiospecific process for the preparation of 4-[1- (4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
WO2005047269A1 (en) * 2003-11-14 2005-05-26 Natco Pharma Limited A method for the separation of the letrozole precursor 4-‘1-(1,2,4-triazolyl) methyl!benzonitrile from its 1,3,4-triazolyl isomer
US20050209294A1 (en) * 2004-03-17 2005-09-22 Wadhwa Lalit K Process for producing 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile

Also Published As

Publication number Publication date
EP1945618A2 (en) 2008-07-23
WO2007054964A2 (en) 2007-05-18
US20100190997A1 (en) 2010-07-29

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DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
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