WO2007066335A3 - Methods for affecting liposome composition by ultrasound irradiation - Google Patents

Methods for affecting liposome composition by ultrasound irradiation Download PDF

Info

Publication number
WO2007066335A3
WO2007066335A3 PCT/IL2006/001404 IL2006001404W WO2007066335A3 WO 2007066335 A3 WO2007066335 A3 WO 2007066335A3 IL 2006001404 W IL2006001404 W IL 2006001404W WO 2007066335 A3 WO2007066335 A3 WO 2007066335A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
liposomes
ultrasound irradiation
liposome composition
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2006/001404
Other languages
French (fr)
Other versions
WO2007066335A2 (en
Inventor
Yechezkel Barenholz
Avi Schroeder
Joseph Kost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ben Gurion University of the Negev Research and Development Authority Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Ben Gurion University of the Negev BGU
Original Assignee
Ben Gurion University of the Negev Research and Development Authority Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Ben Gurion University of the Negev BGU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ben Gurion University of the Negev Research and Development Authority Ltd, Yissum Research Development Co of Hebrew University of Jerusalem, Ben Gurion University of the Negev BGU filed Critical Ben Gurion University of the Negev Research and Development Authority Ltd
Priority to US12/096,652 priority Critical patent/US20090155345A1/en
Priority to EP06821623A priority patent/EP1962796A2/en
Publication of WO2007066335A2 publication Critical patent/WO2007066335A2/en
Anticipated expiration legal-status Critical
Publication of WO2007066335A3 publication Critical patent/WO2007066335A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides methods for loading of agents and substances into per-formed liposomes, preferably a suspension of pre-formed liposomes as well as to methods for the controlled quantum (step-wise) release of agents and substances from liposomes. One of the principle features of the methods of the invention is to expose the liposomes to ultrasound irradiation having predefined parameters, resulting in an increase in permeability of the liposomes, thereby permitting, respectively, the loading and/or release of agents and substances into and/or from the liposomes.
PCT/IL2006/001404 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation Ceased WO2007066335A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/096,652 US20090155345A1 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition ultrasound irradiation
EP06821623A EP1962796A2 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74814905P 2005-12-08 2005-12-08
US60/748,149 2005-12-08

Publications (2)

Publication Number Publication Date
WO2007066335A2 WO2007066335A2 (en) 2007-06-14
WO2007066335A3 true WO2007066335A3 (en) 2008-07-10

Family

ID=38123293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001404 Ceased WO2007066335A2 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation

Country Status (4)

Country Link
US (1) US20090155345A1 (en)
EP (1) EP1962796A2 (en)
CN (1) CN101365424A (en)
WO (1) WO2007066335A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004233873B2 (en) 2003-04-25 2010-11-18 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
WO2007144883A1 (en) 2006-06-13 2007-12-21 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
FR2921253B1 (en) * 2007-09-26 2012-11-16 Lvmh Rech COSMETIC COMPOSITION IN THE FORM OF EMULSION COMPRISING A CONTINUOUS AQUEOUS PHASE AND A DISPERSED FATTY PHASE AND PROCESS FOR PREPARING THE SAME
US20100283570A1 (en) * 2007-11-14 2010-11-11 Lavoie Adrien R Nano-encapsulated magnetic particle composite layers for integrated silicon voltage regulators
US20110020429A1 (en) * 2007-12-10 2011-01-27 Epitarget As Use of particles comprising an alcohol
WO2010017177A1 (en) * 2008-08-06 2010-02-11 The Trustees Of The University Of Pennsylvania Ultrasonically induced release from polymer vesicles
US20110070154A1 (en) * 2008-08-13 2011-03-24 Hyde Roderick A Artificial cells
JP5392707B2 (en) * 2009-03-31 2014-01-22 株式会社Ｎｔｔドコモ Membrane vesicle division system
KR20150062802A (en) * 2013-11-29 2015-06-08 삼성전자주식회사 Double-layerec liposome comprising a inner liposome comprising hydrophobic active ingredient, and use thereof
EP3337457A4 (en) * 2015-08-21 2019-01-02 University of Otago Acoustic driven drug delivery systems
WO2018031980A1 (en) * 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Polyglutamated antifolates and uses thereof
WO2018031968A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Alpha and gamma-d polyglutamated antifolates and uses thereof
CN121177507A (en) 2016-08-12 2025-12-23 L.E.A.F.控股集团公司 α- and γ-D polyglutamylated antifolic acid agents and their uses
WO2019010418A1 (en) 2017-07-07 2019-01-10 Drexel University Voltage-activated therapeutic, diagnostic, and/or theranostic constructs
WO2019157121A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated lometrexol and uses thereof
WO2019157145A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof
EP3749319A4 (en) 2018-02-07 2022-06-22 L.E.A.F Holdings Group LLC ALPHA-POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF
EP3749314A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC METHOTREXATE ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
JP7491572B2 (en) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー Alpha polyglutamated pemetrexed and uses thereof
CA3090389A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
EP3749318A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC RALTITREXED GAMMA-POLYGLUTAMATE AND ASSOCIATED USES
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
US12310966B2 (en) 2018-02-07 2025-05-27 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
CN111867593A (en) 2018-02-07 2020-10-30 L.E.A.F.控股集团公司 Alpha polyglutamate antifolate and use thereof
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
WO2019160735A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
JP7462950B2 (en) 2018-02-14 2024-04-08 エル．イー．エー．エフ． ホールディングス グループ エルエルシー Gamma polyglutamylated methotrexate and uses thereof
CA3090753A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated pralatrexate and uses thereof
US12350271B2 (en) 2018-02-14 2025-07-08 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof
WO2019160734A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593394A1 (en) * 1986-01-30 1987-07-31 Ire Celltarg Sa Method for preparing liposomes containing a lipophilic active substance, in particular amphotericin, and liposomes and new medicament which are obtained
WO2003015831A1 (en) * 2001-08-16 2003-02-27 Bristol-Myers Squibb Pharma Company Gas microsphere liposome composites
US20040258747A1 (en) * 2003-05-29 2004-12-23 Mirco Ponzoni Tumor-targeted drug delivery systems and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
JP2001503396A (en) * 1996-10-11 2001-03-13 アルザ コーポレイション Therapeutic liposome compositions and methods
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
JP2005525992A (en) * 2001-06-25 2005-09-02 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム Methods for the preparation of vesicles filled with biological material and their various uses
US20060002994A1 (en) * 2004-03-23 2006-01-05 Thomas James L Responsive liposomes for ultrasonic drug delivery
US20060127467A1 (en) * 2004-12-14 2006-06-15 Watkin Kenneth L Nanoparticles for delivery of therapeutic agents using ultrasound and associated methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593394A1 (en) * 1986-01-30 1987-07-31 Ire Celltarg Sa Method for preparing liposomes containing a lipophilic active substance, in particular amphotericin, and liposomes and new medicament which are obtained
WO2003015831A1 (en) * 2001-08-16 2003-02-27 Bristol-Myers Squibb Pharma Company Gas microsphere liposome composites
US20040258747A1 (en) * 2003-05-29 2004-12-23 Mirco Ponzoni Tumor-targeted drug delivery systems and uses thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Acoustically active liposomes for oligonucleotide/drug encapsulation; delivery agents with capacity for ultrasound-triggered release", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 9, 1 May 2004 (2004-05-01), pages 183 - 184, XP004634849, ISSN: 1525-0016 *
HUANG S-L ET AL: "Acoustically active liposomes for drug encapsulation and ultrasound-triggered release", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1665, no. 1-2, 11 October 2004 (2004-10-11), pages 134 - 141, XP004592242, ISSN: 0005-2736 *
HUSSEINI G A ET AL: "Factors affecting acoustically triggered release of drugs from polymeric micelles", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 69, no. 1, 3 October 2000 (2000-10-03), pages 43 - 52, XP004217533, ISSN: 0168-3659 *
JUNGHANS M ET AL: "Cationic lipid-protamine-DNA (LPD) complexes for delivery of antisense c-myc oligonucleotides", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 60, no. 2, July 2005 (2005-07-01), pages 287 - 294, XP004923304, ISSN: 0939-6411 *
LIN ET AL: "PEG-Lipids and Oligo(ethylene glycol) Surfactants Enhance the Ultrasonic Permeabilizability of Liposomes", LANMUIR, vol. 19, 2003, pages 1098 - 1105, XP002479875 *
MAYNARD V ET AL: "ULTRASONIC ABSORPTION AND PERMEABILITY FOR LIPOSOMES NEAR PHASE TRANSITION", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR, vol. 37, no. 1, 1 January 1985 (1985-01-01), pages 1 - 12, XP002462217, ISSN: 0009-3084 *
MORSE REEF ET AL: "Ultrasound interaction with large unilamellar vesicles at the phospholipid phase transition: Perturbation by phospholipid side chain substitution with deuterium", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 103, no. 1-2, December 1999 (1999-12-01), pages 1 - 10, XP002462218, ISSN: 0009-3084 *
WIECKOWSKIA M R ET AL: "Long-chain fatty acids promote opening of the reconstituted mitochondrial permeability transition pore", FEBS LETTERS, vol. 484, no. 2, 2000, pages 61 - 64, XP004337712 *

Also Published As

Publication number Publication date
WO2007066335A2 (en) 2007-06-14
EP1962796A2 (en) 2008-09-03
US20090155345A1 (en) 2009-06-18
CN101365424A (en) 2009-02-11

Similar Documents

Publication Publication Date Title
WO2007066335A3 (en) Methods for affecting liposome composition by ultrasound irradiation
WO2008016664A3 (en) Compositions and methods for treating cancer with dacarbazine nanoemulsions
WO2006071613A3 (en) Injectable non-aqueous suspension
WO2006138418A3 (en) Improvement of cognitive performance with sirtuin activators
WO2006071693A3 (en) Injectable non-aqueous suspension
WO2005009409A3 (en) Controlled release preparations
ATE537263T1 (en) CATIONIC LIPIDS AND METHODS OF USE
WO2006093348A3 (en) Method and composition for treating peripheral vascular diseases
WO2005102396A3 (en) Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof
WO2007030743A3 (en) Cochlear implants containing biological cells and uses thereof
WO2006004910A3 (en) Improved bispecific antibodies
WO2009149485A3 (en) Compounds for treating amyloidoses
MX2007008790A (en) Substituted pyrazolo-pyridines, compositions containing them, method for the production thereof, and their use.
WO2006102163A3 (en) Transfection reagents for non-adherent suspension cells
WO2007059430A3 (en) Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
WO2007036939A3 (en) Methods for crop protection
WO2006081435A3 (en) Method of providing readily available cellular material derived from cord blood, and a composition thereof
PL1928836T3 (en) Substituted 4-phenyltetrahydroisoquinolines, method of producing them, their use as medicament, and also medicament containing them
WO2007016352A3 (en) Oral liquid losartan compositions
UA90171C2 (en) Fungicidal composition and process for the preparation thereof
WO2005117848A3 (en) Vascular targets for detecting, imaging and treating neoplasia or neovasculature
WO2006091542A3 (en) Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier
WO2008099469A1 (en) Composition and method for suppressing lipid peroxidation in erythrocytes
WO2007137236A3 (en) Drug loaded contrast agents: combining diagnosis and therapy
WO2010031508A3 (en) Insecticidal gassing agent containing active ingredient in the form of wax particles

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006821623

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200680052544.6

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2006821623

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12096652

Country of ref document: US