WO2007066335A3 - Methods for affecting liposome composition by ultrasound irradiation - Google Patents

Methods for affecting liposome composition by ultrasound irradiation Download PDF

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Publication number
WO2007066335A3
WO2007066335A3 PCT/IL2006/001404 IL2006001404W WO2007066335A3 WO 2007066335 A3 WO2007066335 A3 WO 2007066335A3 IL 2006001404 W IL2006001404 W IL 2006001404W WO 2007066335 A3 WO2007066335 A3 WO 2007066335A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
liposomes
ultrasound irradiation
liposome composition
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2006/001404
Other languages
French (fr)
Other versions
WO2007066335A2 (en
Inventor
Yechezkel Barenholz
Avi Schroeder
Joseph Kost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ben Gurion University of the Negev Research and Development Authority Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Ben Gurion University of the Negev BGU
Original Assignee
Ben Gurion University of the Negev Research and Development Authority Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Ben Gurion University of the Negev BGU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ben Gurion University of the Negev Research and Development Authority Ltd, Yissum Research Development Co of Hebrew University of Jerusalem, Ben Gurion University of the Negev BGU filed Critical Ben Gurion University of the Negev Research and Development Authority Ltd
Priority to EP06821623A priority Critical patent/EP1962796A2/en
Priority to US12/096,652 priority patent/US20090155345A1/en
Publication of WO2007066335A2 publication Critical patent/WO2007066335A2/en
Anticipated expiration legal-status Critical
Publication of WO2007066335A3 publication Critical patent/WO2007066335A3/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides methods for loading of agents and substances into per-formed liposomes, preferably a suspension of pre-formed liposomes as well as to methods for the controlled quantum (step-wise) release of agents and substances from liposomes. One of the principle features of the methods of the invention is to expose the liposomes to ultrasound irradiation having predefined parameters, resulting in an increase in permeability of the liposomes, thereby permitting, respectively, the loading and/or release of agents and substances into and/or from the liposomes.
PCT/IL2006/001404 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation Ceased WO2007066335A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06821623A EP1962796A2 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation
US12/096,652 US20090155345A1 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition ultrasound irradiation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74814905P 2005-12-08 2005-12-08
US60/748,149 2005-12-08

Publications (2)

Publication Number Publication Date
WO2007066335A2 WO2007066335A2 (en) 2007-06-14
WO2007066335A3 true WO2007066335A3 (en) 2008-07-10

Family

ID=38123293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/001404 Ceased WO2007066335A2 (en) 2005-12-08 2006-12-07 Methods for affecting liposome composition by ultrasound irradiation

Country Status (4)

Country Link
US (1) US20090155345A1 (en)
EP (1) EP1962796A2 (en)
CN (1) CN101365424A (en)
WO (1) WO2007066335A2 (en)

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WO2007144883A1 (en) 2006-06-13 2007-12-21 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
FR2921253B1 (en) * 2007-09-26 2012-11-16 Lvmh Rech COSMETIC COMPOSITION IN THE FORM OF EMULSION COMPRISING A CONTINUOUS AQUEOUS PHASE AND A DISPERSED FATTY PHASE AND PROCESS FOR PREPARING THE SAME
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US20110020429A1 (en) * 2007-12-10 2011-01-27 Epitarget As Use of particles comprising an alcohol
US20110195501A1 (en) * 2008-08-06 2011-08-11 Pangu Gautam D Ultrasonically induced release from polymer vesicles
US20120034155A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
JP5392707B2 (en) * 2009-03-31 2014-01-22 株式会社Ｎｔｔドコモ Membrane vesicle division system
KR20150062802A (en) * 2013-11-29 2015-06-08 삼성전자주식회사 Double-layerec liposome comprising a inner liposome comprising hydrophobic active ingredient, and use thereof
US11260126B2 (en) * 2015-08-21 2022-03-01 University Of Otago Acoustic driven drug delivery systems
WO2018031967A1 (en) 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Polyglutamated antifolates and uses thereof
EA201990473A1 (en) 2016-08-12 2019-07-31 Эл.И.Эй.Эф. ХОЛДИНГС ГРУП ЭлЭлСи Polyglutamated antipholates and their use
WO2018031980A1 (en) * 2016-08-12 2018-02-15 L.E.A.F. Holdings Group Llc Polyglutamated antifolates and uses thereof
EP3648758A4 (en) 2017-07-07 2021-04-28 Drexel University VOLTAGE ACTIVATED THERAPEUTIC, DIAGNOSTIC AND / OR THERANOSTIC CONSTRUCTS
WO2019157123A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated aminopterin and uses thereof
US11779584B2 (en) 2018-02-07 2023-10-10 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
CN111954529A (en) 2018-02-07 2020-11-17 L.E.A.F.控股集团公司 Alpha polyglutamated methotrexate and uses thereof
EP3749318A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC RALTITREXED GAMMA-POLYGLUTAMATE AND ASSOCIATED USES
CA3090389A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
US12220431B2 (en) 2018-02-07 2025-02-11 L.E.A.F. Holdings Group Llc Gamma polyglutamated antifolates and uses thereof
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC GAMMA POLYGLUTAMATED PEMETREXED AND USES THEREOF
CA3090506A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated tetrahydrofolates and uses thereof
EP3749312A4 (en) 2018-02-07 2022-02-23 L.E.A.F Holdings Group LLC LOMETREXOL ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
EP3749316A4 (en) 2018-02-07 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE ALPHA-POLYGLUTAMATE AND ASSOCIATED USES
US12076402B2 (en) 2018-02-07 2024-09-03 L.E.A.F. Holdings Group Llc Alpha polyglutamated antifolates and uses thereof
EP3752156A4 (en) 2018-02-14 2021-10-27 L.E.A.F Holdings Group LLC PRALATREXATE GAMMA-POLYGLUTAMATE AND ASSOCIATED USES
US12048766B2 (en) 2018-02-14 2024-07-30 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
CN111936145A (en) 2018-02-14 2020-11-13 L.E.A.F.控股集团公司 Gamma polyglutamated methotrexate and uses thereof
US11771700B2 (en) 2018-02-14 2023-10-03 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
CA3090943A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated aminopterin and uses thereof

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US20040258747A1 (en) * 2003-05-29 2004-12-23 Mirco Ponzoni Tumor-targeted drug delivery systems and uses thereof

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WO2003015831A1 (en) * 2001-08-16 2003-02-27 Bristol-Myers Squibb Pharma Company Gas microsphere liposome composites
US20040258747A1 (en) * 2003-05-29 2004-12-23 Mirco Ponzoni Tumor-targeted drug delivery systems and uses thereof

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Also Published As

Publication number Publication date
EP1962796A2 (en) 2008-09-03
US20090155345A1 (en) 2009-06-18
WO2007066335A2 (en) 2007-06-14
CN101365424A (en) 2009-02-11

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