WO2007080400A2 - Ace n-domain crystal - Google Patents

Abstract

The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain, specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.

Description

CRYSTAL

FIELD OF INVENTION 5

The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein.

The present invention also relates to methods, processes, domain specific modulators, 10 pharmaceutical compositions and uses of the N-domain crystal and the structure coordinates thereof.

BACKGROUND TO THE INVENTION

15. Angiotensin-converting enzyme (peptidyl dipeptidase A, EC 3.4.15.1, ACE) is a zinc- dependent dipeptidyl carboxypeptidase with diverse physiological functions, including that of blood pressure regulation via angiotensin II production and bradykinin inactivation.

20 Somatic ACE (sACE), a type- I transmembrane protein, is composed of two homologous catalytic domains (N- and C- domains) arising from ^~s gene duplication event (Soubrier et al., 1988): The. germinal form-of ACE (testis ACE, (tACE)) (Ehlers- et al., 1989) originates from the- same _gene as sACE, but has a tissue-specific promoter- located within ϊntron 12. Testis- ACE plays a crucial role in reproduction

25 (Hagaman et al.,.1998)

Despite sharing ~ 60 % sequence identity with the C-domain, the N-domain has its own distinctive physicochemical and functional properties. It is thermally more stable than the C-domain (Voronov et al., 2002), more resistant to proteolysis under denaturing 30 conditions and is less dependent on chloride activation relative to the C-domain (Wei et al., 1991; Jaspard et al., 1993). The N- and the C-domains are joined by a linker that is susceptible to proteolysis (Sturrock et al., (1997), Biochem. Biophys. Res. 236, 16-19). It has also been suggested that the N- and the C-domains have unique physiological roles and that they have negative effect on each other (Woodman et al., 2005). Substrates such as the hemoregulatory peptide AcSDKP (Rousseau et al., 1995), angiotensin 1-7 (Deddish et al., 1998), and the enkephalin precursor Met⁵-Enk-Arg⁶- Phe⁷ (Deddish et al., 1997) are specific for the N-domain, whereas the physiological substrates bradykmin and angiotensin I are hydrαlysed with similar catalytic efficiency as compared with the C-domain.

It has been reported thatrthe N-domain preferentially Tiydrolyses^~the A beta peptide of the amyloid precursor protein resulting in inhibition of A beta aggregation and cytotoxicity (Oba et al., 2005). The widely-used ACE inhibitor €aptopril shows modest selectivity for the N-domain (Wei et al., 1992); however, the-phosphinic peptide inhibitor RXP-407 has a dissociation constant three orders of magnitude lower for the N-domain of the enzyme (Dive etal., 1999).

The N-domain has 10 N-linked sites of which 7 are unique to the Ν-domain. The different glycan profile of the Ν-domain is likely responsible for the carbohydrate- mediated dimerisation of sACE which has been described under certain conditions (Kost et al., 2003). Moreover, the difference in glycosylation could impact on the structural basis for epitope recognition and epitope mapping of the Ν-domain has revealed a region mat might play a role in .the relatively .inefficient eGtodomain shedding of sACE compared to its germinal isofornr(Balyasnikova et al., 2005).

Both the Ν- and the C-domains of ACE protein are heavily glycosylated in nature, a feature that has hampered 3D structural determination of the protein and of- each of the domains.

We previously described the 3D structure of -the ACE protein (International Patent Application PCT/GB03/03966 (published as WO 04/024765). This 3D structure was that of the underglycosylated C-domain of ACE protein.

This underglycosylated 3D structure, however, provides limited information on the structure of the Ν-domain of ACE, nor is it ideal for screening or designing domain specific modulators suitable for pharmaceutical use nor indeed for studying the functional interaction between the Ν- and the C-domains of ACE protein. Therefore there is a need to obtain a crystal of the N-domain of ACE protein with sufficient quality to allow crystallographic data to be obtained. Further, there is a need for such a crystal to allow the determination of the crystal structure of the N-domain of ACE. Finally there is a need for procedures for studying the interplay between the N- andthe C-domains and screening for domain specific modulators using the 3D structural information of the N-domain of ACE protein.

SUMMARY OF THE INVENTION

The present inventors Uave now- for the first time been able to -describe the three- dimensional structure of the N-domain of s ACE protein.

According to a first aspect of the present invention there is provided a crystal of the N-domain of ACE protein. Preferably the N-domain of ACE protein is minimally glycosylated.

Preferably, the N-domain of ACE protein is minimally glycosylated by incorporating one or more glycosylation sites and/or one or more partially glycosylated sites. More preferably, the minimally glycosylated N-domain of ACE protein is minimally glycosylated at amino acids 25, 45, 117, 289 and 48.0 of SEQ ID NO: 1.

Preferably the N-domain of ACE protein comprises an inter-domain linker region. This linker region joins the N- and the- C-domains sasi- has been reported -to be susceptible to proteolysis (Sturrock et al., (1997)^ Biochem. Biophys. Res. 236^-16-19). No one has previously visualised this linker region in a 3D structure. No one has- previously analysed the physiological role of this linker region and no one has previously studies -the role of the linker in the functional interplay between the N- and the C-domains based on 3D structural data.

Preferably, the crystal of the N-domain of ACE protein comprises atoms arranged in a spatial relationship represented by at least a portion of the structural co-ordinates set forth in Table A or Table B. Preferably, the crystal belongs to the space group C222\.

Preferably, the crystal has the unit cell dimensions: a=101.12 A₅ b=211.32 A, c=171.27

A.

5

Preferably, the crystal is a crystal of the N-domain of human ACE protein.

Preferably, the crystal of the N-domain of ACE protein comprises a ligand bound to the N-domain of ACE protein or a portion thereof. More preferably the ligand 0 modulates the activity of the N-domain of ACE protein. More preferably the ligand^' is .an inhibitor of the N-domain. of ACE protein such as lisinopril or a derivative thereof. More preferably the crystal of the N-domain of the ACE protein comprising lisinopril comprises atoms^arranged in a spatial relationship represented by at least a portion of the structural co-ordinates set forth in Table B. 5

Preferably the crystal of the N-domain of the ACE protein comprising the inhibitor lisinopril has the unit cell dimensions of: a=101.32 A, b=211.90 A, c=171.03 A.

In a second aspect, the present invention relates to a method of preparing a crystal of Q- the N-domain of ACE protein comprising the steps of: (a) culturing host cells- expressing N-dbmain of ACE protein; (b) purifying the N-domain of ACE protein; and (c) crystallising the N-domain of AGE protein.

Preferably, the N-domain of ACE protein is crystallised ^"using about 5 mM HEPES 5 and about 0.1 mM PMSF with an equal volume of a reservoir solution containing- about 0.2M lithium sulphate, about 15 % PEG 4000, about 100 mM CH₃COONa.3H₂O pH 4.9 and about 10 μM-ZnSC-₄-7H₂O.

Preferably, the crystal that is prepared has a structure defined by at least a portion of 0 the structural co-ordinates set forth in Table A or Table B.

Preferably, the crystal belongs to the space group C222_\. Preferably, the crystal has the unit cell dimensions: a=101.12 A, b=211.32 A, c=171.27

A.

Preferably, the N-domain of ACE protein is the N-domain of human ACE protein.

Preferably, the N-domain of ACE protein is crystallised in the presence of a ligand. More preferably the ligand is a modulator of the N-domain of ACE protein. More preferably the ligand is an inhibitor of the N-domain of ACE protein such as lisinopril or a derivative thereof. More preferably the crystal of the N-domain of the ACE protein comprising lisinopril comprises atoms arranged in- a spatial relationship represented by at-least a portion of the structural co-ordinates set- forth in Table B.

Preferably the crystal of the N-domain of the- ACE protein comprising the inhibitor lisinopril has the. unit cell dimensions of: a=101.32 A_> b=211.90 A, c=171.03 A.

Preferably the crystal of the N-domain of ACE protein that is prepared in the presence of a ligand is crystallised using about 5 mM HEPES and about 0.1 mM PMSF with an equal volume of a reservoir solution containing about 0.2M lithium sulphate, 18 % PEG 4000, about 100 mM CH₃COONa.3H₂O pH 4.9 and about 10 μM ZnSO₄JH₂O..

hi a third aspect, the present invention relates to a method of screening Tor a

-modulator of the N-domain of ACE protein wherein-the method comprises the use of a crystal .according to the present invention. Preferably, the screening method comprises the steps of: (a) providing at least a portion of the structural co-ordinates set forth in Table A or Table B; (b) employing at least a portion of the structural coordinates set forth in Table A or Table B to design or select or synthesise a putative modulator of the N-domain of ACE protein; (c) contacting the putative modulator of the N-domain with the N-domain or a mutant, variant, homologue, derivative or fragment thereof in the presence of a substrate; and (d) screening the putative modulator of the N-domain of ACE protein in an assay for the potential to modulate the N-domain. Comparisons of the 3D structures of the N-domain of ACE protein and C-domain of ACE protein show that the two domains are structurally very similar.

Therefore, according to a fourth aspect, the present invention relates to a method of -screening for a modulator of the C-domain of ACE protein wherein the method comprises the use of a crystal according to the present invention. Preferably, the screening method comprises the steps of: (a) providing at least a portion of the structural co-ordinates set forth in Table A or Table B; (b) employing at least a portion of the structural co-ordinates set forth in Table A or Table B to design or select or -synthesise a putative modulator of the C-domain of ACE protein; (c) contacting the putative modulator of the C-domain with the C-domain or a mutant, variant, homologue, derivative or fragment thereof; and (d) screening the putative modulator of the C-domain of ACE protein in an -assay for the potential to modulate the C-domain.

Preferably, at least a portion of the structural co-ordinates set forth in Table A or Table B and/or the putative modulator of the N-domain of ACE protein or C-domain of ACE protein and/or the substrate are provided on a machine-readable data storage medium comprising a data storage material encoded"with machine readable data.

Preferably, the putative N-domain of ACE protein modulator or C-domaiα of ACE protein-modulator is selected-from a library of compounds. More preferably, the putative N-domain of ACE protein modulator σrC-domain of ACE protein modulator is selected from a database. More preferably, the putative-N-domain of ACE protein modulator or C-domain of ACE protein modulator is designed de novo. More preferably, the putative N-domain of ACE protein modulator or C-domain of ACE protein modulator is designed from a known ACE modulator. More preferably, the design or selection-of the putative N-domain of ACE protein modulator or C-domain of ACE protein modulator is performed in conjunction with computer modelling.

Preferably, the putative N-domain of ACE protein modulator or C-domain of ACE protein modulator is useful in the prevention and/or treatment of ACE related disorder. More preferably, the ACE related disorder is hypertension, myocardial infarction or congestive heart failure. In a fifth aspect, the present invention relates to a process comprising the steps of: (a) performing the method according to the third aspect and/or the fourth aspect of the present invention; (b) identifying one or more modulators of the N-domain and/or C- domain; and (c) preparing a- quantity of those one or more N-domain modulators and/or C-domain modulators.

In a sixth aspect; the present invention rektesi;o a process-comprising the-steps of: (a) performing the method according to the third aspect and/or the fourth aspect of the present invention; Qy) identifying one or more N-domain modulators and/or C-domain modulators; and (c) preparing a pharmaceutical composition comprising those one or more N-domain modulators and/or C-domain modulators.

In a seventh aspect, the present invention relates to a process comprising the steps' of: (a) performing the method according to the third aspect and/or the fourth aspect of the present invention; (b) identifying one or more N-domain modulators and/or C-domain modulators; (c) modifying those one or more N-domain modulators and/or C-domain modulators; and (d) optionally preparing a pharmaceutical composition comprising those one or more N-domain modulators and/or C-domain modulators.

In an eighth aspect, the present invention relates to a method of obtaining structural information about a molecule or a molecular complex of unknown structure by^using at least a portion ef-the structure eo-ordinates of the N-domain of ACE protein, comprising the steps of: (a) generating X-ray diffraction data from a crystallised jnolecule or molecular complex; (b) applying at least a- portion of the structure coordinates of the N-domaήrof ACE protein to said X-ray diffraction pattern to generate .a -three dimensional -electron density map of at least a portion of the molecule or molecular complex; and (c) using all or a portion of the structure co-ordinates of the N-domain of ACE protein to generate homology models of the N-domain of ACE protein. Preferably the structural information of the structure co-ordinates of ACE protein are used for domain co-operativity studies.

In a ninth aspect, the present invention relates to a modulator of the N-domain of ACE protein and/or the C-domain of ACE protein identified by the method according to the third aspect and/or the fourth aspect of the present invention. Preferably, the modulator inhibits the N-domain of ACE protein and/or the C-domain of ACE protein.

In a tenth aspect, the present invention relates, to a- pharmaceutical composition comprising an N-domain of ACE protein modulator and/or a C-domain of ACE protein modulator according to the ninth aspect of the present invention and a pharmaceutically -acceptable carrier, diluent, excipient or adjuvant or any combination thereof.

hi an eleventh aspect, the_ present invention relates to a-τnethod of preventing and/or treating an ACE related disorder comprising administering a modulator of the N- domain of ACE protein and/or the C-domain of ACE jgrotein according to the ninth aspect of the present invention and/or a pharmaceutical composition- according to the tenth aspect of the present invention, wherein said modulator of the N-domain of ACE protein and/or the C-domain of ACE protein and/or said pharmaceutical composition is capable of causing a beneficial preventative and/or therapeutic effect.

In a twelfth aspect, thejpresent invention relates to a computer for producing a three- dimensional representation of the N-domanx-of ACE protein wherein said computer comprises: (a) a computer-readable data storage medium comprising a data storage material encoded with computer-readable data, wherein said, data comprises the -structure co-ordinates σf-the N-domain of ACE-protein; (b) a working memory for storing instructions for -processing said computer-readable data; (c) a centraL- processing unit coupled to said working memory and to said- computer-readable data storage- medium for processing said computer-machine^" readable data into said three- dimensional representation;_and (d) a display coupled to said central-processing unit for displaying said three-dimensional representation.

In a thirteenth aspect, the present invention relates to a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein the data is defined by at least a portion of the structural co-ordinates of the N- domain of ACE protein set forth in Table A or Table B. In a fourteenth aspect, the present invention relates to the use of an N-domain of ACE protein crystal in the preparation of a medicament to prevent and/or treat an ACE related disorder. Preferably, the A.CE related disorder is hypertension, myocardial infarction or congestive heart failure.

In a fifteenth aspect, the present invention relates to the use of at least a portion of the structural co-ordinates set forth in Table A or Table B to screen for modulators of the N-domain of ACE^'protein and/or C-domain of ACE protein.

In a- sixteenth aspect, the present invention relates to the use of aHeast a portion of the structural co-ordinates set forth in Table A or Table B to solve the structure of the crystalline form of any other domain with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein-

In a seventeenth aspect, the present invention relates to the use of at least a portion of the structural co-ordinates set forth in Table A or Table B in molecular design techniques to design, select and synthesise modulators of the N-domain of ACE protein and/or C-domain of ACE protein.

hi an eighteenth aspect, the present invention^" relates to the use of at least .a-portion of the structural co-ordinates set forth in Table A or Table B in- the development of icoinpounds that can isemerise-to reaction intermediates--in-the chemical reaction- of a substrate^or other compound that binds to the N-domain-of ACE protein and/or the C- domain of ACE- protein.

hi a nineteenth aspect, the presentinvention relates to the use of at least a portion of-the structural co-ordinates set forth in Table A or Table B- to screen small molecule databases for chemical entities or compounds that modulate the N-domain of ACE protein and/or C-domain of ACE protein.

hi a twentieth aspect, the present invention relates to the use of at least a portion of the structural co-ordinates set forth in Table A or Table B to solve the structure of the crystalline form of any other domain with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein. Preferably, the structure of the crystalline form of any other domain with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein is solved using molecular replacement.

In a twenty first aspect, the present invention relates to the use of at least a portion of the structural co-ordinates set forth in Table A or Table B to identify the binding site of any modulator of the N-domain of ACE protein. Preferably the binding site is that of Iisinopril or derivatives thereof.

DETAILED DESCRIPTION OF THE INVENTION

N-DOMAIN OF ACE PROTEIN

ACE (EC 3A15.1) is a membrane associated peptidyl dipeptidase.

There are two tissues specific isoforms of ACE protein differentially transcribed from the same gene.

Somatic ACE {sACE), a type I transmembrane protein, is composed of two homologous catalytic N- and C- domains, arising from a gene- duplication event (Soubrier et al., 1988).

Germinal'ACE (testis ACE, (£ACE))--has a tissue-specificjpromoter located within istron 12 (Ehlers et al, 1989).

Despite sharing ~ 60 % sequence identity with the C-domain, the N-domain has its own distinctive physicochemical and functional properties. It has also, been reported that the two domains display negative co-operativity effect on each other (Woodman et al., 2005). In the present invention, co-operativity studies between the N- and C- domains of ACE protein is based on studies carried out by Guy et al., 2003 (Biochemistry, 42:13185-13192) and Towler et al., 2004 (The Journal of Biological Chemistry, 17:17996-18007). In their studies, the authors compare ACE structures with those of the ACE2 homologue that more closely resembles the N-domain of the ACE protein. See Figure 4 below. As used herein the term "negative co-operativity" refers to the capacity of the two domains of ACE protein to modulate the biochemical activities of each other. By way of example the N-domain may cause steric hindrance of the C-domain by preventing substrate from accessing the active site of the C-domain and vice versa the C-dbmain may cause steric hindrance of the N-domain by preventing substrate from accessing the active site of the N-domain.

The N- and the C-domains are heavily glycosylated, which has hampered the determination of the 3D structure of me ACE protein.

Previously we described the 3D structure of the C-domain of undeglycosylated ACE protein- (see International Patent Application PCT/GB03/03966 (published as WO 04/024765)).

The present inventors have now been able to obtain a minimally glycosylated N- domain of ACE protein.

As used herein the term "minimally glycosylated" means that one or more oligosaccharide chains are linked to one or more amino acid residues in the N-domain of ACE protein. As used herein the'term "oligosaccharide" refers to a carbohydrate molecule- which comprises less than.10 sugar molecules where the sugar molecules can be any one or more of mono-saccharides, di-,.tri-, and/or tetra-saccharides.

As used herein, 1he term "N-domain of ACE protein" includes ail vertebrate and mammalian forms of the N-domain of ACE protein and is intended to cover mutants, variants, homologues, derivatives and fragments thereof. Preferably, the mutants, variants, homologues, derivatives and fragments thereof have the activity of the N- domain of ACE protein. Preferably the N-domain of the ACE protein is minimally glycozylated. CRYSTAL

In one aspect of the present invention, there is provided a crystal structure of the N- domain of ACE protein in its minimally glycozylated form and its ligand-bound form.

As used herein, the term "crystal" means a structure (such as a three dimensional (3D) solid aggregate) in which the plane faces intersect at definite angles and in which there is a regular structure (such as internal structure) of the constituent chemical species. Thus, the term "crystal" can include any one of: a solid physical crystal form such as an experimentally prepared crystal, a 3D model based on the crystal structure, a representation thereof - such as a schematic representation thereof, a diagramatic representation thereof, or a data set thereof for a computer.

The crystals of the present invention may be prepared by purifying the N-domain of ACE protein and then crystallising the purified protein. The N-domain of ACE protein may also be prepared by expressing a nucleotide sequence encoding the N- domain of ACE protein in a suitable host cell.

In one preferred embodiment, the N-domain of ACE -crystal comprises the inter- domain, linker region.

The N-domain of ACE protein may be purified using, various-methods^" known to .a person skilled in the art, for example, from conditioned media- by- affinity chromatography on a_Sepharose-28-lisinopril affinity resin (Yn et al. 1997). The protein may be quantified by amino acid analysis and assayed for activity- using_^ the substrate hippuryl-L-histidyl-L-leucine, as described previously (Ehlers, MRE, Chen, Y -N₅ Riordan, JF (1991) Proc. Natl. Acad. ScL USA 88, 1009-1013).

The purified N-domain of ACE proteins may be stored at —20 °C in 5 mM HEPES and 0.1 mM PMSF.

Concentration may be performed with the aid of a filtration system and the protein concentrate may be immediately used for crystallisation purposes. The protein concentrate may be crystallised using, for example, the vapour diffusion hanging drop method at a temperature of from about 4 ⁰C to about 30 ⁰C, preferably from about 8 ⁰C to about 20 ⁰C, more preferably from about 12 ⁰C to about 18 ⁰C, most preferably at about 16 ⁰C. The crystallisation temperature may be dependent on the additives present ^"5 in Hie protein- solution.

Typically, the best crystals for the N-domain of ACE proteins are grown at a temperature in the range of from 10 to 20⁰C, preferably from 12 to 18⁰C, most preferably at 16 °C by the vapour diffusion hanging drop method by mixing 1 μl of 0 the_protein solution at about 4 mg/ml. The solution comprising HEPES in the range of from 1 to IOJSM, preferably in the range of from 2 to 8 mM, more preferably in the range of from 4 to 6 mM, most preferably 5mM HEPES and PMSF in the range of from 0.025 to 0.2%, preferably from 0.O5 to 0.15%, -more preferably from 0.075 to 0.125, -most preferably 0.1% PMSF with- an equal volume of a reservoir solution. The 5 reservoir solution comprising lithium sulphate in the range of from 0.025 to 0.4M, preferably in the range of from 0.05 to 0.35M, more preferably from 0.075 to 0.3M, most preferably containing 0.2M lithium sulphate, PEG 4000 in the range of from 5% to 25%, preferably from 10% to 20%, most preferably from 15% to 18% PEG 4000, CH₃COONa.3H₂O in the range of from 50 to 15OmM, preferably from 75 to 125 mM, 0 more preferably -from 90 to 110 mM,. most preferably 100 -mM^~CH₃COONa,3E₂O, wherein th^~e-CH₃COONa.3H₂O has a pH in the range of from 3.9 to 5.9, preferably a pH from 4.5 to 5.5; more-preferably a pHirom 4.7 to 5.2, moϊstpreferably a pH of 4.9 and^~ZnS_O₄.7H₂O in the range_of from 5- to 20μM, preferably from 7.5 to 12.5 μM, most preferably 10 μM ZnSO₄JH₂O. 5^"

Crystals usually appear within 1 to 2 weeks and grow to their maximum size after about a month.

The present invention related to a crystal of the N-domain of ACE comprising atoms 0 arranged in a spatial relationship represented by at least a portion of the structural coordinates set forth in Table A or Table B. preferably, the crystal belongs to the space group C222χ and unit cell dimensions: a=101.12 A, b=211.32 A₃ c=171.27 A.

Preferably, the N-domain of ACE protein is the N-domain of any vertebrate and mammalian.

Preferably the N-domain of ACE protein is the N-domain of human ACE protein.

Complexes may. be obtained by growing the crystals in the presence of a ligand - such as a test compound. Tn these experiments the protein solution is mixed with the ligand and an equal volume of the reservoir -solution before setting up the crystallisation. Single crystals suitable for diffraction work typically appear after about 1-2 weeks.

Typically, the protein comprising the N-domain of ACE protein is purified to homogeneity for crystallisation. Purity of the N-domain of ACE protein may be measured by typical techniques such as SDS-PAGE, mass spectrometry and hydrophobic HPLC.

The structure of the crystals of the invention may contain a portion - such as at least 25%, at least 50%, at least 75%, or preferably at least 90%, at least 95%, at least 98%, or at least -99% - of the co-ordinates set forth in Table A or Table B. Preferably, the crystaLstructure of the invention contains all of the co-ordinates set forth in Table A or Table Br

Preferably, the crystals are usable-in X-ray crystallography techniques.

Preferably, the- crystals used can "withstand exposure to X-ray beams used to produce diffraction pattern data necessary to solve the X-ray crystallographic structure.

Preferably, prior to data collection, the crystals are flash-cooled at about 100 K rn a cryoprotectant. The cryoprotectant comprising lithium sulphate in the range of from 0.025 to 0.4M, preferably in the range of from 0.05 to 0.35M, more preferably from 0.075 to 0.3M, most preferably containing 0.2M lithium sulphate, PEG 4000 in the range of from 5% to 25%, preferably from 10% to 20%, most preferably from 15% to 18% PEG 4000, CH₃COONa.3H₂O in the range of from 50 to 15OmM, preferably from 75 to 125 mM, more preferably from 90 to 110 mM, most preferably 100 mM CH₃COONa.3H₂O, wherein the CH₃COONa.3H₂O has a pH in the range of from 3.9 to 5.9, preferably a pH from 4.5 to 5.5, more preferably a pH from 4.7 to 5.2, most preferably a pH of 4.9 and ZnSO₄JH₂O in theTange offionxS to 20μM, preferably from 7.5 to 12.5 μM, most preferably 10 μM ZnSO₄.7H₂O.

The X-ray data may be collected at a Synchrotrsn Radiation Source. Preferably, the X-ray data are collected at a Synchrotron Radiation S.ource at 100 ⁰K.

Preferably, the crystal has a resolution determined by X-ray crystallography of about 3.5A or less, more preferably a resolution of about 3.0 A or less, more preferably a resolution of about 2.8A or less, more preferably, a resolution of about 2 A or less, more preferably, a resolution of about 1.5 A or less, most preferably, 1 A or less.

GLYCOSYLATION OF THE N-DOMAIN OF ACE PROTEIN

Many proteins in eukaryotic cells are glycoproteins that contain oligosaccharide chains covalently linked to certain amino acids. Glycosylation is known .to affect protein folding, interaction between proteia. domains, localisation and trafficking, protein solubility, antigenicity, biological activity and^" half-life, -as well as cell-cell interactions.

Protein glycosylation can be divided into four main categories mainly depending-on the linkage- between the amino acid and the -sugar -molecule. These are N-linked glycosylation, O-linked glycosylation.,. C-mannosylation and GPI anchor attachments. N-glycosylation is characterised by the addition of a sugar to~the amino group of an asparagine.

For N-glycosylation, the sequence motif Asn-Xaa-Ser/Thr (wherein Xaa is any amino acid other than Pro) has been defined as a prerequisite for glycosylation. Although rare, the sequence motif Asn-Xaa-Cys can also be an acceptor site. Ν-glycans can be subdivided into three distinct groups called 'high mannose type', "hybrid type', and 'complex type', with, the common pentasaccharide core - Manp(alphal,6)- (Manp(alphal,3))-Manp(betal,4)-GlcpNAc(betal,4) GlcpNAc(betal,N)-Asn - occurring in all three groups. The relationship between all three types can be ascribed to the fact that they originate from one precursor oligosaccharide which contains the described common pentasaccharide core Man3-GlcNAc2, and some additional sugar residues and the non-reducing end, and is then processed enzymatically to yield these three types. Since the hydroxyl group of Ser/Thr is thought to be involved in hydrogen bonding during the enzymatic attachment of the oligosaccharide precursormslecule to yield a favourable conformation for the action of the oligosaccharyltransferase, it has been suggested for proline that the steric hindrance might be too large (Kornfeld (1-985) Ann... Rev. Biochem. 54: 631-64), preventing glycosylation at Pro containing sites. The negative influence of aspartic acid towards glycosylation can be ascribed to the negative charge on the side chain of this residue. In addition some cases have been- reported where Ser/Thr is replaced by cysteine. While Ser replacement by Cys generally leads to decreased glycosylation, it has been shown (Kasturi 1995 J. Biol. Chem. 270: 14756-61) that substitution by Thr at a given potential glycosylation site can lead to increased glycosylation. This is in accordance with the model of hydrogen bonding being an important factor during the attachment of the precursor molecule to the protein. Although there are usually many potential glycosylation sites in a protein it has been estimated that glycosylation occurs only at one third of them. Mostly at those sites where the surrounding amino acids allow the formation of a beta turn.

Various _.glycoforms of- ACE have been described. By way of example, Sadhukhan & Sen disrupted specific glycosylation sites in rabbit tACE to elucidate the glycosylation- requirements, for the expression and processing of-active testis ACE. There are five potential N-linked glycosylation sites in the rabbit tACE sequence, with an additional six in the somatic form. A null mutant, where all five sites had been disrupted, behaved similarly to wild-type tACE expressed in the presence of the glycosylation-inhibitor, tunicamycin. It was degraded intracellularly and failed to be detected in culture medium, confirming previous findings that tACE requires N-linked glycosylation to be expressed in an active form. Expression of the remaining mutants showed a preference for N-linked glycosylation at the Ν-terminus and that the presence of sugars at a single Ν-terminal site was necessary and sufficient to produce enzymatically-active tACE that was solubilised. The presence of glycosylation is not site-specific, as mutants that have either the first site or second site intact are expressed and active. However, glycosylation at the third site alone is not sufficient to produce active protein in HeLa cells, albeit this mutant was expressed in yeast, indicating that the requirements for glycosylation are cell-specific.

N-linked glycosylation of human tACE expressed in CHO cells at each site has been identified by MALDI-TOF mass spectrometry. There are seven potential N-linked sites in human tACE, five of which are complementary to the sites in rabbit tACE (7a). The unique sites lie within the ectodomain (the fourth site) and in the juxtamembrane stalk region, adjacent to the cleavage site (the seventh site). As with the rabbit form, there appears to be a preference for glycosylation_at the Ν-terminus as evidenced by MALDI-TOF mass spectrometry of glycopeptides (Yu et al., 1997) and mutagenesis (Gordon et al., 2003) of glycosylation sites. Inhibition of complex oligosaccharide formation using a glucosidase I inhibitor N-butyldeoxynojirimycin (ΝB-DΝJ) led to the production of an active glycoform that was electrophoreticalϊy homogeneous.

There are ten putative N-glycosylation sites on the human Ν-domain of ACE protein and Fourier difference density was observed at five of these sites according to the crystal ofϋie present invention.

Suitably, the crystal of the Ν-domain of ACE protein may comprise minimally glycosylated Ν-domain of- ACE- protein-or a fragment thereof. For example, the minimally glycosylated Ν-domain of ACE protein may comprise the sequence presented as SEQ ID No. 1.

To obtain a minimally glycosylated N-domain of ACE protein, various methods known to a person skilled in the art may be used. Both chemical and enzymatic methods may be used. Hydrazinolysis of glycoproteins (Kuraya, N & Hase (1992) J Biochem (Tokyo) 112:122- 126), is capable of removing both N- and O-linked sugars, although this results in the complete destruction of the protein component and is therefore not suitable if recovery of the protein is desirable. More delicate chemical methods may be used such as trifluoromethanesulphonic acid (TFMS), however this method may also lead to a partial protein destruction. Alternatively, or in addition, other methods - such as site directed mutagenesis of glycosylated amino acids may also be employed.

Enzymatic methods which provide for partial sugar removal with no protein degradation may also be used.

Use of the enzyme PNGase F is an effective method of removing most N-linked oligosaccharides from glycoproteins (Tarentino & Plummer (1994) Methods in- En∑ymology, 230: 44-57). The oligosaccharide is left intact and therefore suitable for further analysis (the asparagine residue from which the sugar is removed is deaminated to aspartic add, the only modification to the protein).

Other commonly used endoglycosidases include Endoglycosidase H (Kobata (1979) Anal Biochem 100:1-14) and Endoglycosidase F (Trimble & Tarentino (1991) J. Biochem. 266:1646-1651). In a preferred method, the Ν-domain of ACE protein is digested with Endoglycosidase H (30 mU) in a suitable buffer - such as 100 mM sodium phosphate, 0.1 mM ZnCl₂ and 1% BSA, pH 6.0 for 16 h at 37⁰C. The endo H-treated protein is passed through a lectin affinity column consisting of equal parts of concanavalin A, wheat germ, and lentil lectin, after equilibration with 20 mM Tris- HCl; 0.5 M NaCl at pH 7.4. The minodeglycosylated ACE is collected in the flowthrough. Free oligosaccharides and any other impurities are removed from the flowthrough fraction bv-a-fmal lisinopril-Sepharose affinity chromatography step. The homogeneity of the ACE protein after .deglycosylation is-confirmed by SDS.-PAGE on a 4-2t3% acrylamide gel and MALDI-TOF mass spectrometry.

By way of example, a minimally glycosylated Ν-domain of ACE protein can be obtained by incubating suitable .host cells such -as CHO cells until confluent and then substituting the growth medium with medium comprising 1% FCS, 0.05% albumax I (Gibco BRL), 20μM MSX and 1.5mM of the glucosidase I inhibitor Ν- butyldeoxynojirimycin (ΝB-DΝJ) (Toronto Research Chemicals Inc.B691000 Lot 14- EG-91-1 andB691000 12-Cf-146-2). Preferably, the crystal of the N-domain of ACE protein comprises glycosylated N- domain of ACE protein or a fragment thereof. More preferably, the crystal of the N- domain of ACE protein comprises a minimally glycosylated N-domain of ACE protein or a fragment thereof. More preferably, the crystal of the N-domain of ACE protein comprises N-glycosylation of asparagine residues. More, preferably the asparagine residues are N-glycosylated with high mannose oligosaccharides.

Preferably, one or more of the asparagine residues of the Ν-domain of ACE protein can be N-glycosylated. More preferably, one or more of the asparagine residue of SEQ ID No: 1 are N-glycosylated. More, preferably one or more, of the asparagine residues 25, 45, 117, 289 and 480 of SEQ ID^"Νo: 1 can be N-glycosylated.

PREPARING A CRYSTAL OF THE N-DOMAIN OF ACE PROTEIN

In another aspect, the present invention relates to a method of preparing a crystal of the N-domain of ACE protein, comprising the steps of (a) culturing host cells comprising N- domain of ACE protein; (b) purifying the N-domain of ACE protein; and (c) crystallising the N-domain of ACE protein.

Preferably, the N-domaitr of ACE protein comprises -an inter-domain linker region.

The N-domain of ACE-protein may be purifiedrusing the methods describedlerem.

Preferably, the N-domain of ACE protein is. crystallised Jn the presence-ef afligand, for example, a-modulator ofthe N-domain of ACE .protein.

MODULATORS

The role of ACE protein in the pathogenesis of hypertension has resulted in an intensive search for modulators (eg. inhibitors) of the enzyme that could act as antihypertensive drugs (eg. US 3,891,616, US 3,947,575, US 4,052,511 and US 4,053,651). Therapeutic vasodepressors - such as the compound captopril (D-2-methyl-3-mercaptopropanoyl-L- proline) - have been synthesised as ACE inhibitors. Numerous synthetic peptide derivatives have also been shown to be ACE inhibitors as disclosed in US 3,832,337. Natural substances that inhibit ACE include snake venom and those derived from foodstuffs - such .as ACE inhibiting peptides produced by enzymatic hydrolysis of proteins, such as casein or fish meat protein (by Hiroyuki Ukeda, Nippon Nogei Kagaku Kaishi (Journal of Japan Society for Bioscience, Biotechnology, and Agrochemistry, 66(1), 25-29 (1992)).

ACE inhibiting synthetic substances include^" captopril (D-2-methyl-3- mercaptopropanoyl-L-proline) which, has already been put to practical application as an orally administered vasodepressor.

However, many currently used ACE inhibiting substances exhibit side effects in many cases and special attention needs to be exercised.

The present invention offers a novel concept in the field of ACE protein inhibitor design by providing conditions suitable for generating specific inhibitors to more precisely target and regulate the activity of the N- and/or C- domains of ACE protein. Preferably the modulators are N-domain of ACE protein specific and/or C-domain of ACE protein specific. These novel modulators can advantageously have reduced side effects.

The present -invention provides the use- of molecular design techniques- -to design, select- and synthesise chemical entities and compounds, including ACE modulating compounds, capable-.of binding to -the N-domain of ACE protein, in whole or in parL

Thus, in a further aspect, the present invention relates to a method of screening for a modulator of the N-domain of ACE protein wherein the method comprises the use of a crystal of the N-domain of ACE protein.

Preferably, the method comprises the steps of: (a) providing at least a portion of the structural co-ordinates set forth in Table A or Table B; (b) employing at least a portion of the structural co-ordinates set forth in Table A or Table B to design or select or synthesise a putative modulator of the N-domain of ACE protein; (c) contacting the putative modulator of the N-domain of ACE protein with the N-domain of ACE protein or a mutant, variant, homologue, derivative or fragment thereof in the presence of a substrate; and (d) screening the putative modulator of the N-domain of ACE protein, in an assay for the potential to modulate the N-domain.

By way of example, the structure-co-ordinates, may- be used to design compounds that bind to the N-domain of ACE enzyme and may alter the physical properties of the compounds (e.g. solubility) or the domain or the enzyme itself. This invention may be used to design compounds that-acirasτirodulators - such as competitive inhibitors- - of the N-domain of ACE protein by binding to all or a portion of the active site of the N-domain of ACE protein. Compounds may also be- designed that, act as noncompetitive inhibitors of the N-domain ef ACE -protein. These non-competitive inhibitors may bind to all or a portion of the N-domain of ACE protein already bound to its substrate- and may be more potent and specific than known N-domain of ACE protein inhibitors that compete only Jbr the N-domain of ACE protein active site. Similarly, non-competitive inhibitors that bind to and inhibit the N-domain of ACE protein whether or not it is bound to another chemical ligand may be designed using the structure co-ordinates of the N-domain of ACE protein as described herein.

By way of example, it may be found that the COOH-binding active site residue differs between the N- and C-domain of ACE protein active sites and/or that it may be amenable to the incorporation^" of a ^"functionality that can covalently modify this residue to produce- an irreversible domain-specific inhibitor design.

Due to the signi-ficantstπictural similarity between the N-domain and-the C-domain of ACE protein it is envisaged-that the structural- co-ordinates of the crystal of the N- domain can also be used to design modulators which are specific for the C-domain of ACE protein.

Accordingly, in a further aspect, the present invention relates to a method of screening for a modulator of the C-domain of ACE protein wherein the method comprises the use of a crystal of the N-domain of ACE protein. Preferably, the method comprises the steps of: (a) providing at least a portion of the structural co-ordinates set forth in Table A or Table B; (b) employing at least a portion of the structural co-ordinates set forth in Table A or Table B to design or select or synthesise a putative modulator of the C-domain of ACE protein; (c) contacting the putative modulator of the C-domain of ACE protein with the C-domain of ACE protein or a mutant, variant, homologue, derivative or fragment thereof in the presence of a substrate; and (d) screening the putative modulator of the C-domain of ACE protein in an assay for the potential to modulate the C-domain.

By way of example, the structure co-ordinates of the N-domain may be used to design compounds that bind to the C-domain of ACE enzyme and may alter the physical properties of the compounds (e.g. solubility) or the domains or the enzyme itself. This invention may be used to design compounds that act as modulators - such as competitive inhibitors - of the C-domain of ACEprotein by binding to all^' or a portion of the active site of the C-domain of ACE protein. Compounds may also be designed that act as non-competitive inhibitors of the C-domain of ACE protein. These noncompetitive inhibitors may bind to all or a portion- of the C-domain of ACE protein already bound to its substrate and may be more potent and specific than known C- domain of ACE protein inhibitors thatxompete only for the C-domain of ACE protein active site. Similarly, non-competitive inhibitors that bind to and inhibit the C- domain of ACEprotein whether or not it is bound to another chemical ligand maybe designed using the structure co-ordinates of the N-domain of ACE protein as described herein. Advantageously, the specific modulators of the C-domain of ACE protein do not adversely affect the enzymatic activity of the N-domain of ACE protein. By way of example, such C-domain specific- inhibitors can permit the N- domain to hydrolyse the vasodilator bradykinin and thus- alleviate side-effects such as persistent cough and angioedema. Accordingly, the C-domain specific modulators identifϊed_by the screening- methods described- herein may have the capacity to overcome certain side effects. By way of a further example, the C-domain specific inhibitors can also permit the hydrolysis of the N-domain specific hεmoregulatory peptide AcSDKP.

En a preferred embodiment, at least a portion of the structural co-ordinates set forth in Table A or Table B and/or the putative modulator of the N-domain of ACE protein or C-domain of ACE protein and/or the substrate are provided on a machine-readable data storage medium comprising a data storage material encoded with machine readable data. A crystal of the N-domain of ACE may be probed with a variety of different chemical entities or test compounds to determine optimal sites for interaction between modulators of the N-domain of ACE protein or the C-domain of ACE protein and the enzyme. For example, X-ray diffraction data collected from crystals jjrown in the presence of chemical entities or test compounds may allow the elucidation of how the chemical entities or test compounds interact with the N-domain of ACE protein or the C-domain of ACE protein. Molecules that bind to those sites can then be designed and synthesised and tested for their capacity to modulate the activity of the N-domain of ACE protein.

The present invention may also allow the development of compounds that can isomerise to reaction intermediates in the chemical reaction of a substrate or other compound that bind to the N-domain of ACE protein or the C-domain of ACE protein. Thus, the time-dependent analysis of structural changes in the N-domain of ACE protein during its interaction with other molecules may be performed. The reaction intermediates of the N-domain of ACE protein or the C-domain of ACE protein may also be deduced from the reaction product in complex with the N-domain of ACE protein. Such information is especially useful to design improved analogues of known N^"-domain or C-domaih modulators or to design new ^"N-domain or C- domain modulators based on the reaction intermediates and the modulator complex. This-may provide SL new route for designing N-domain or C-domairrOf ACE protein modulators with high dømain specificity and stability. Preferably, this provides a new route for. designing N-domain ox -C-domain. of ACE protein modulators with high domain specificity, high stability and low toxicity.

Small molecule databases or test compounds may be screened foiLchemical entities or compounds that can bind in whole, or in part, to the N-domain or C-domain of ACE protein. Thus, in a preferred embodiment, the putative N-domain or C-domain modulator is selected from a library of compounds or a database. In this screening, the quality of fit of such entities or compounds to the binding site may be judged by various methods - such as shape complementarity or estimated interaction energy (Meng, E. C. et al., J. Comp. Chem., 13, pp. 505-524 (1992)). Because the N-domain of ACE protein or a mutant, variant, homologue, derivative or fragment thereof may crystallise in more than one crystal form, the structure coordinates of the N-domain of ACE protein, or portions thereof, may be particularly useful to solve the structure of other crystal forms of the N-domain of ACE protein. They may also be used to solve the structure of the N-domain of ACE protein mutants, N-domain of ACE protein variants, N-domain of ACE protein homologues, N-domain of ACE protein derivatives, N-domain of ACE protein fragments and N- domain of ACE protein complexes.

Preferably, the structure co-ordinates of the N-domain of ACE protein are used to solve the structure of the crystalline form of any other protein with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein. By way of example, .molecular replacement may be used. In this method, the unknown crystal structure, whether it is another crystal form of the N-domain of ACE protein, N-domain of ACE protein mutant, N-domain of ACE protein variant, N- domain of ACE protein homologue (eg. another protein with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein), N- domain of ACE protein derivative, N-domain of ACE protein fragments or N-domain of ACE protein complex may be determined using the N-domain of ACE protein structure- co-ordinates of the present invention. This method will provider a more accurate structural form for the unknown crystal more quickly and efficiently than attempting to determine such information ab initio.

Preferably, the structural co-ordinates- of the N-domain of ACE .pr-stem are used for domain interplay or also referred to as domain, co-αperativity studies. By way -of" example, molecular replacement may be used. In this method, unknown domain co- operativity with N-domain of ACE protein, N-domain of ACE protein mutant, N- domain of ACE protein variant, N-domain of ACE -protein homologue (e.g. another protein with significant amino acid sequence homology to the N-domain of ACE protein), N-domain of ACE protein derivative, N-domain of ACE protein fragments or N-domain of ACE protein complex may be determined using the N-domain of ACE protein structure co-ordinates of the present invention. This method will provide a more accurate structural form for the unknown crystal more quickly and efficiently than attempting to determine such information ab initio. As used herein the term "domain co-operativity" refers to the capacity of each of the domains of ACE protein to modulate the biochemical activities of each other. As used herein the term "modulate" means to affect, to vary, to adjust, to increase, to decrease or generally to be able to regulate or modify the biochemical activity of the N- or C- domain of ACE ptoein.

Preferably the structural co-ordinates of N-domain oFACE protein are used to study co-operativity between the N-domain of ACE protein and the C-domain of ACE protein.

hi a preferred embodiment of the present invention, the crystal of the N-domain of ACE protein further comprises a ligand bound to the ACE protein or a portion thereof. For example, the N-domain of ACE protein may be crystallised in a complex with a ligand that is an inhibitor of the N-domain of ACE protein e.g. lisinopril, captopril or RXP407.

By way of example the inhibitor is bound to the N-domain of ACE protein or a portion thereof by contacting one of more residues of the N-domain of ACE protein selected from: Ghi259, Tyr3^"69, Lys489 and Tyr498.

The crystal structures of a series^" of such complexes may then be solved by-molecular replacement or irr combination with MAD (Multiwavelength Anomalous Dispersion) and/or MIRAS (Multiple- Isomoiphous Replacement with Anomalous Scattering) procedures - and compared with tiiat of minimally glycosylated N-domain .of ACE protein. Potential sites for modification within the binding sites-θf the N-domain may thus be identified. This information provides an additional tool for determining the most efficient binding interactions, for example, increased hydrophobic interactions, between the N-domain of ACE protein and a ligand or a compound.

The information will also provide ideal conditions for designing domain specific inhibitors to more precisely regulate the biochemical functions of the N- and C- domains of ACE protein. The structures and complexes of the N-domain of ACE protein may be refined using computer software - such as X-PLOR (Meth. Enzymol, vol. 114 & 115, H. W. Wyckoff et al., eds., Academic Press (1985)), MLPHARE (Collaborative computational project Number 4. The CCP4 Suite: Programs for Protein Crystallography (1994) Acta Crγstallogr. D 50, 760-763) and SHARP [De La Fortelle, E. & Bricogne, G. Maximum-likelihood heavy-atom parameters refinement in the MIR and MAD methods (1997) Methods Enzymol. 276, 472-494). Preferably, the complexes are refined using the program CNS (Brϋnger et al., (1998) Acta Crystalϊogr. D 54, 905-921). During the final stages of refinement water molecules, ions and inhibitor molecules may be inserted in the structure. This information may thus be used to optimise known classes- of modulators of the N-domain of ACE protein, eg. inhibitors, and more importantly, to design and synthesise novel classes of domain specificrmodulators.

The overall figure of merit may be improved by iterative solvent flattening, phase combination and phase extension with the program SOLOMON (Abrahams, J. P. & Leslie, A. G. W. Methods used in structure determination of bovine mitochondrial Fl ATPase. (1996) Acta Ciγstallogr. D 52, 110-119).

The -structure co-ordinates of the mutants of the N-domaiπ ef ACE provided in this invention also facilitate the identification of related domains or enzymes analogous to the N-domain-of ACE protein injunction, structure or .both, thereby further leading to -novel therapeutic-modes for treating or preventing ACE related diseases.

The design of compounds that bind- to or modulate the N-domain of ACE protein or the C-domain of ACE protein according to the present invention _.generally involves consideration of two factors.

First, the compound must be capable of physically and structurally associating with the N-domain or the C-domain of ACE protein. Non-covalent molecular interactions important in the association of the N-domain of ACE with its substrate may include hydrogen bonding, van der Waals and hydrophobic interactions. Second, the compound must be able to assume a- conformation that allows it to associate with the N-domain or C-domain of ACE protein. Although certain portions of the compound may not directly participate in the association with the N-domain or C-domain of ACE, those portions may still influence the overall conformation of the 5 molecule. This may have a significant impact on potency of the compound. Such conformational requirements include the overall three-dimensional structure and orientation of the chemical ligand or compound in relation to all or a portion of a binding site of the N-domain or C-domain of ACE, or the spacing between functional groups of a compound comprising several chemical entities that directly interact with o the N-domain or C-domain of ACE.

The potential modulating or binding effect of a chemical compound on the N-domain or the C-domain of ACE may be analysed prior to its actual synthesis and testing by the use of computer modelling techniques. If the theoretical structure of the given 5 compound suggests insufficient interaction and association with the N-domain or the C-domain of ACE, then synthesis and testing of the compound may- be obviated. However, if computer modelling indicates a strong interaction, the molecule may be synthesised and tested for its ability to bind to the N-domain or the C-domain of ACE and modulate (e,g. inhibit) using the fluorescent substrate assay of Thomberry et al., 0 (200Oj Methods Enzymol. 322_* 100-110. In this manner, synthesis of inactive compounds may be avoided.

_*

A modulating or other binding compound of the N-domain or the C-domain of ACE may -be computationally evaluated and- designed by means of a series of steps in 5 which chemicaL entities or test compounds -are "screened and selected for their ability to associate witLthe N-domain orthe C-domain of ACE.

A person skilled in the art may use one of several methods to screen chemical entities or test compounds for their ability to associate with the N-domain or the C-domain of 0 ACE and more particularly with the individual binding sites of the N-domain or the C-domain of ACE. This process may begin by visual inspection of, for example, the active site on the computer screen based on the N-domain or the C-domain of ACE co-ordinates of the present invention. Selected chemical entities or test compounds may then be positioned in a variety of orientations, or docked, with the N-domain or 2S

the C-domain of ACE. Docking may be accomplished using software such as Quanta and Sybyl, followed by energy minimisation and molecular dynamics with standard molecular mechanics force fields - such as CHARMM and AMBER.

Specialised computer programs may also assist in the process- of selecting chemical entities or test compounds. These include but are not limited to MCSS (Miranker and Karplus (1991) Proteins: Structure, Function and Genetics, 11, 29-34); GRID (Goodford (1985) J. ^~Med. Chem., 28, 849-857) -and- AUTODOCK (Goedsell and Olsen (1990), Proteins: Structure. Function, and Genetics, 8, 195-202).

Once- suitable chemical entities or test compounds have been selected, they may be assembled into a single compound capable of modulating the domains of the ACE protein e.g. the N-domaki and/or the C-domain of the ACE protein. Assembly may proceed by visual inspection of the relationship of the chemical entities or test compounds in relation to the structure co-ordinates of the N-domain of ACE protein. This may be followed by manual model building using software - such as Quanta, Sybyl or O [Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. A 47, 110-119].

Refinement of the_model may be. carried out using the program CNS [Brϋnger, A. T. et aL, Crystallography & TSlMR System: A new software suite for macromolecular structure determination. (1998) Acta Qγstallogr. D 54, 905-921].

Various programs may be used by a, skilled-person to connect the individual" chemical entities or test compounds - such as 3D Database systems (Martin (1992) J. Med. Chem., 35, 2145-2154) and CAVEAT (Bartlett et al., (1989) Royal Chem. Soc. 78, 182-196).

Rather than build an inhibitor of the N-domain or the C-domain of ACE protein one chemical ligand at a time, modelling of other N-domain or C-domain binding compounds may be designed as a whole or de novo using either an empty binding site or optionally including some portion(s) of a known inhibitor(s). Such compounds may be designed using programs that may include but are not limited to LEGEND (Nishibata and Itai (1991) Tetrahedron, 47, 8985) and LUDI (Bohm (1992) J. Comp. Aid. MoUc. Design, 6, 61-78).

Other molecular modelling techniques may also be employed in accordance with this invention - such as those described by Cohen et al, J. Med. Chem_^ 33, 883-894 (1990); Navia and Murcko (1992) Current Opinions in Structural Biology, 2, 202-210 (1992).

Once a compound has been designed or selected by the above methods, the efficiency with which that compound may bind to the N-domain or the C-domain of AGE protein may be computationally evaluated. Specific computer software may be used^" to evaluate the efficiency of binding (eg. to evaluate compound deformation energy and electrostatic interaction) - such as QUANTA/CHARMM (Accelrys Inc., USA) and Insight II/Discover (Biosym Technologies Inc., San Diego, Calif, USA). These programs may be implemented, for instance, using a suitable workstation. Other hardware systems and software packages will be known to those persons skilled in the art.

Once a modulating compound has been selected or designed, as described above, substitutions may ^"be made (eg. rh atoms or side groups) to improve or modify the binding properties. The substitutions may be conservative i.e. the replacement- group may have approximately the same size, shape, hydrophobiciiy- and charge as the original -group. Such substituted-chemical compounds may-then be analysed for efficiency of binding -tcrthe N-domain or C-domaήτ of ACE by the same computer methods described above.

Test compounds andjnodulators-of the N-domain or C-domain of ACE protein which- are identified using the crystal and the methods of the present invention may be screened in assays. Screening can be, for example in vitro, in cell culture, and/or in vivo. Biological screening assays preferably centre on activity-based response models, binding assays (which measure how well a compound binds), and bacterial, yeast and animal cell lines (which measure the biological effect of a compound in a cell). The assays can be automated for high capacity-high throughput screening (HTS) in which large numbers of compounds can be tested to identify compounds with the desired activity.

Current screening technologies are described in Handbook of Drug Screening, edited by Ramakrishna Seethala, Prabhavathi B. Fernandas. New York, NY, Marcel Dekker, (2001).

DISORDERS

These include, but are not limited to, treatment of high-blood pressure; treatment σfheart failure; prolonging survival of patients who have had a heart attack; preventing death by heart attack and stroke in patients with vascular disease and in diabetics with other vascular -risk factors; prolonging survival of patients with weak heart muscle; helping leaking heart valves; preserving kidney function in diabetics; and the treatment of new indications (e.g. polycythemia). Special groups of patients may also be treated with N- domain or C-domain of ACE inhibitors, including patients with chronic pulmonary disease, patients with schleroderma, patients with atheroschlerosis, and patients with hyperuricemia.

It is also envisaged that the modulators identified by the methods described herein may be used to treat Alzheimer's disease and other degenerative diseases, conditions or disorders of the CNS.

ACE CONSTRUCTS

The N-domain of ACE protein produced by a host recombinant cell may be secreted or may be contained intracellularly depending on the nucleotide sequence and/or the vector used.

The skilled person would understand that expression vectors containing the N-domain of ACE protein encoding nucleotide sequence or a mutant, variant, homologue, derivative or fragment thereof, may be designed with signal sequences which direct secretion of the N-domain of ACE protein coding sequences across a particular prokaryotic or eukaryotic cell membrane. The N-domain encoding sequence may be fused (e.g. ligated) to nucleotide sequences encoding a polypeptide domain which will facilitate purification of soluble proteins (Kroll DJ et al., (1993) DNA Cell Biol 12:441-53). Preferably, the polypeptide domain which facilitates purification of soluble proteins is fused in frame with the N-domain of the ACE protein encoding sequence. Such purification facilitating domains include, but are not limited to, metal chelating peptides - such as histidine-tryptophan modules that allow purification on immobilised^~metals (Porath T (1992) Protein Expr Purifi, 263- 281), protein A domains that allow purification on immobilised immunoglobulin, and the domain utilised in the FLAGS extension/affinity purification system (Immunex Corp, Seattle, WA). The-inclusion of a cleavable linker sequence such as Factor XA or enterokinase (Invitrogen, San Diego, CA) between the purification domain and ACE is useful to facilitate purification.

Preferably the N-domain of ACE protein sequence is fused with the glutathione synthetase (GS) signal

Preferably, the N-domain of ACE protein is secreted in a soluble form host cells and can be harvested from the growth medium.

Preferably, the N-domain of ACE construct is pEE 14 ^{^}N-domain which encodes the N- domairt of human tACE. This construct comprises the inter-domain linker region.

HOST CELL

As used herein, the term "host cell" refers tα any cell that comprises nucleotide sequences that are of use in the present invention, for example, nucleotide sequences encoding the N-domain of ACE protein.

Host cells may be transformed or transfected with a nucleotide sequence contained in a vector e.g. a cloning vector. Preferably, said nucleotide sequence is carried in a vector for the replication and/or expression of the nucleotide sequence. The cells will be chosen to be compatible with the said vector and may for example be prokaryotic such as bacterial or eukaryotic such as fungal, yeast or plant cells. The gram-negative bacterium E. coli is widely used as a host for cloning nucleotide sequences. This organism is also widely used for heterologous nucleotide sequence expression. However, large amounts of heterologous protein tend to accumulate inside the cell. Subsequent purification of the desired protein from the bulk of E. coli intracellular proteins can sometimes be difficult.

In contrast to E. coli, bacteria from the genus Bacillus- are" very suitable as heterologous hosts because of their capability to secrete proteins into the culture medium. Other bacteria .suitable a& hosts are those from the genera Streptomyces and Pseudomonas.

Depending on the nature of the polynucleotide and/or the desirability for further processing of the expressed protein, eukaryotic hosts including yeast or other fungi may be preferred. In general, yeast cells are preferred over fungal cells- because yeast cells are easier to manipulate. However, some proteins are either poorly secreted from the yeast cell, or in some cases are not processed properly (e.g. hyperglycosylation). Ia these instances, a different fungal host organism should be selected.

Examples of expression hosts are fungi - such as Aspergillus- species -(such as those described in EP-A-01&4438 and EP-A-0284603) and Trichβderma species; baeteria - such as Bacillus species (such- as those described in EP-A-0134048 and EP-A- 0253455), Streptomyces species and Pseudomonas species; -yeast - such as Kluyveromyces species (such as those described in EP-A-0096430 and EP-A- 0301670) and Saccharomyces species; mammalian cells - such as CHO-Kl cells.

The use of host cells may provide for post-translational modifications (e.g. glycosylation) as may be needed to confer optimal biological activity on recombinant expression products of the present invention.

Aspects of the present invention also relate to host cells comprising the N-domain of ACE protein constructs of the present invention. The N-domain of ACE protein constructs may comprise a nucleotide sequence for replication and expression of the sequence. The cells will be chosen to be compatible with the vector and may for example be prokaryotic such as bacterial or eukaryotic such as fungal, yeast or plant cells.

Ih- a preferred embodiment, the host cells are mammalian cells - such as CHO-Kl cells. CHO-Kl cells expressing the N-domain of ACE protein may be grown and maintained in accordance with Yu et al. (1997).

NUCLEOTIDE SEQUENCES

As used herein, the term "nucleotide sequence" refers to nucleotide sequences, oligonucleotide sequences, polynucleotide sequences and variants, homologues, fragments and derivatives thereof (such as portions- thereof) which comprise the nucleotide sequences encoding the N-domain oFACE protein, for example, the N- domain of testis ACE protein or the N-domain of somatic ACE protein.

The nucleotide sequence may be DNA or RNA of genomic or synthetic or recombinant origin, which may be double-stranded or single-stranded whether representing the sense or antisense strand or combinations thereof. -

Preferably, the term nucleotide sequence is prepared by use of recombinant DNA- techniques (e.g. recombinant DNA). The nucleotide sequences may- include within them synthetic or modified nucleotides. A number of different types of modification to oligonucleotides are— known in the art. These include methylphosphonate and . phosphorofhioate backbones-adαrtion of acridine or polylysine chains at the 3' and/or 5' ends of the molecule. For the purposes of the present invention, it is to be understood that the nucleotide sequences described herein may be modified by any method available in the art.

It will be understood by a skilled person that numerous different nucleotide sequences can encode the same protein as a result of the degeneracy of the genetic code, m addition, it is to be understood that skilled persons may, using routine techniques, make nucleotide substitutions that do not substantially affect the activity encoded by the nucleotide sequence of the present invention to reflect the codon usage of any particular host organism in which the target is to be expressed.

The terms "variant", "homologue" or "derivative" in relation to nucleotide sequences include any substitution of, variation of, modification of, replacement of, deletion of or addition of one (or more) nucleic acid from or to the sequence providing the resultant nucleotide sequence encodes a functional protein according to the present invention (or even a modulator of the N-domain of ACE protein according to the presenrinvention if said modulator comprises a nucleotide sequence).

AMINO ACID SEQUENCES

As used herein, the term "amino acid sequence" is- synonymous with the term "polypeptide" and/or the term "protein". In some instances, the term "amino acid sequence" is synonymous with the term "peptide".

Aspects of the present invention concern the use of amino acid sequences, which may be available in databases. These amino acid sequences may comprise N-domain of ACE proteins,-

The amino acid sequence may be isolated from a suitable source, or it may be made synthetically or it may-be prepared by use of recombinant DNA techniques.

The terms "variant", "homologue" or "derivative" in relation to -amino acid sequences include any substitution of, variation of, modification-of,^~repiacement of, deletion of or addition of one (or more) amino acid from the-functional protein according to the present invention (or even-a.modulator of the N-domain of ACE protein according to the present invention if said modulator comprises an amino acid sequence).

Preferably, the N-domain of ACE protein comprises SEQ ID No. 1 or a mutant, variant, homologue, derivative or a fragment thereof.

PURITY Preferably the protein solution used for crystallisation is at least 95.5% pure. More preferably the protein solution used for crystallisation is at least 97.5% pure. More preferably, the protein solution used for crystallisation is at least 99.0% pure. Most preferably, the protein solution used for crystallisation is at least 99.5% pure.

MODEL

As used herein, the terπr "model" refers to a structural model such as a three dimensional (3D) structural model (or representation thereof) comprising the N- domain of ACE protein. ■

Test compounds can be modelled that bind spatially and preferentially to the N- domain of ACE protein - such as to bind spatially and preferentially to the N-domain of ACE protein - for example, the active site of the N-domain of ACE protein.

Preferably, the crystal model comprising the N-domain of ACE is built from all or a portion of the structural co-ordinates set forth in Table A or Table B.

MUTANT

As used herein, the term "mutant" refers to the N-domain of ACE protein comprising any one or mere changes in the wild-type ACE sequence shown as SEQ ID No. 1.

The term "mutant" is not limited to any of the mutations described herein wbish are. reflected in amino acid substitutions of the amino acid residues in. the N^"-domain af ACE protein, but are not limited to, other deletions or insertions-of nucleotides which may result in changes in the amino acid residues in the amino acid sequence of the N- domain of ACE protein.

The present invention also enables the solving of the crystal structure of mutants of the N-domain of ACE protein. More particularly, by virtue of the present invention, the location of the active site of the N-domain of ACE protein based on its crystal structure permits Hie identification of desirable sites for mutation. For example, one or more mutations may be directed to a particular site - such as the active site - or combination of sites. Similarly, only a location on, at or near the inter-domain linker region may be replaced, resulting in an altered domain co-operativity by changing the charge of one or more charge units, as compared to the wild-type N-domain. Alternatively, an amino acid residue in the inter-domain linker region of the N-domain of ACE may be chosen for replacement based on its hydrophilic or hydrophobic characteristics.

Such mutants may be characterised by any one of several different properties as compared with wild-type N-domain-of ACE protein, Eor example,- such mutants may have altered surface charge of one or more charge units, or have an increased stability to subunit dissociation, or an altered substrate specificity in comparison with, or- a higher specific activity than, wild-type of the N-domain of ACE protein.

The mutants may be prepared in a number of ways that are known by a person skilled in the art. For example, mutations may be introduced by means of oligonucleotide- directed mutagenesis or other conventional methods. Alternatively, mutants of the N- domain of ACE protein may be generated by site specific replacement of a particular amino acid with an unnaturally occurring amino acid. This may be achieved by growing a host organism capable of expressing either the wild-type or mutant polypeptide on a growth medium depleted of one or more natural amino acids but enriched in one or more corresponding unnaturally occurring amino acids.

The expression, activity (e.g. kinetic constants) and/or the crystallisation properties of the mutants-may be determined using the methods described herein.

VARIANTS/HOMOLOΘUES/DERΓ^ATΓVES/FRAGMENTS

The N-domain of ACE protein described herein is intended to include any polypeptide, which has the activity of the naturally occurring N-domain and includes all vertebrate and mammalian forms. Such terms also include polypeptides that differ from naturally occurring forms of the N-domain by having amino acid deletions, substitutions, and additions, but which retain the activity of the N-domain of ACE protein. The term "variant" is used to mean a naturally occurring polypeptide or nucleotide sequences which differs from a wild-type or a native sequence.

The term "fragment" indicates that a polypeptide or nucleotide sequence comprises a fraction of a wild-type or a native sequence. It may comprise one or more large contiguous sections of sequence or a plurality of small sections. The sequence may also comprise other elements of sequence, for example, it may be a fusion protein with another protein. Preferably the sequence comprises at least 50%, more preferably at least 65%, more preferably at least 80%, most preferably at least 90% of the wild-type sequence.

The present invention also encompasses the use of variants, homologues and derivatives of nucleotide and amino acid sequences. Here, the term "homologue" means an entity having a certain homology with amino acid sequences or nucleotide sequences. Here, the term "homology" can be equated with "identity".

In the present context, a homologous sequence is taken to include an amino acid sequence which may be at least 75%, 85% or 90% identical, preferably at least 95% or 98% identical to the subject .sequence. Although homology can also be considered in terms of similarity (Le. amino acid residues having similar chemical properties/functions), it is preferred here to express homology fn terms of sequence identity.

Homologous sequence-is taken to include a nucleotide sequence-which may be at least 75%, -85% or 90% identical, preferably at least- 95%- or 98% identical to the subject sequence.

Homology comparisons can be conducted by eye, or more usually, with the aid of readily available sequence comparison programs. These commercially available computer programs can calculate % homology between two or more sequences.

Homology when based on percentage (%) may be calculated over contiguous sequences, i.e. one sequence is aligned with the other sequence and each amino acid in one sequence is directly compared with the corresponding amino acid in the other sequence, one residue at a time. This is usually referred to "ungapped" alignment. Typically, such ungapped alignments are performed only over a relatively short number of residues.

Although this is a very simple and consistent method, it fails to take into consideration that, for example, in an otherwise identical pair of sequences, one insertion or deletion will cause the following amino acid residues to be put out of alignment, thus potentially resulting in a large reduction in % homology when a global alignment is performed. Consequently, most sequence comparison methods are designed to produce optimal alignments that take into consideration possible insertions and deletions without penalising unduly the overall homology score. This is achieved by inserting "gaps" in the sequence alignment to try to maximise local homology.

However, these more complex methods assign "gap penalties" to each gap that occurs in the alignment so that, for the same number of identical amino acids, a sequence alignment with as few gaps as possible - reflecting higher relatedness between the two compared sequences - will achieve a higher score than one with many gaps. "Affine gap costs" are typically used that charge a relatively high cost for the existence of a gap and a smaller penalty, for each subsequent residue in- the gap. This is the most commonly used gap scoring system. -High gap penalties will of course produce optimised alignments with: fewer gaps. Most alignment programs- allow the gap penalties to "be modified. However, it is preferred to. use the default values when using such software- for sequence, comparisons. -For example when using the GCG- Wisconsin Bestflt paekage the default gap penalty for amino acid sequences is -12 for a gap and -4 for each extension.

Calculation of maximum % homology therefore firstly requires the production of an optimal alignment, taking into consideration gap penalties. A suitable computer program for carrying out such an alignment is the GCG Wisconsin Bestfit package (University of Wisconsin, U.S.A.; Devereux et al., 1984, Nucleic Acids Research 12:387). Examples of other software than can perform sequence comparisons include, but are not limited to, the BLAST package (see Ausubel et al., 1999 ibid — Chapter 18), FASTA (Atschul et al., 1990, J. MoI. Biol, 403-410) and the GENEWORKS suite of comparison tools. Both BLAST and FASTA are available for offline and online searching (see Ausubel et al., 1999 ibid, pages 7-58 to 7-60). However, for some applications, it is preferred to use the GCG Bestfit program. A new tool, called BLAST 2 Sequences is also available for comparing protein and nucleotide sequence (see FEMS Microbiol Lett 1999 174(2): 247-50; FEMS Microbiol Lett 1999 177(1): 187-8)

Although the final % homology -can be measured in terms of identity, the alignment process itself is typically not based on an all-or-nothing pair comparison. Instead, a scaled similarity score matrix is generally used that assigns scores to each pairwise comparison ^"based on chemical similarity or evolutionary distance. An example of such a matrix commonly used is the BLOSUM62 matrix - the default matrix for the BLAST suite of programs. GCG Wisconsin programs generally use either the public default values or a custom symbol comparison table if supplied (see user manual for further details). For some applications, it is preferred to use the public default values for the GCG package, or in the case of other software, the default matrix, such as BLOSUM62.

Once the software has produced an optimal alignment, it is possible to calculate % homology, -preferably % sequence identity. The-softwareJypϊcally does this as part of the sequence comparison and generates a numerical result.

By way of example, homologous sequences of the N-domain of ACE protein include, but are-not limited te-human ACEs somatic ACE. (accession number: J04144), human ACET testis ACE (accession number: M26657), human -ACEH/ACE2 (accession numbers: AAF78220; BAB40370; AAF99721), chimp ACE_T (accession number: AF193487_2), rabbit ACE_T mature protein (accession number: P22968), rabbit ACE_x full pre-protein (accession number: P22968), mouse ACEx testis ACE (accession number: P22967), bovine Cdom ACEs C-domain, rat Cdom ACEs C-domain (derived from accession number P47820; starting D616), human Ndom ACEs N-domain (derived from accession number P12821 (J04144)), chimp Ndom ACEs N-domain (derived from accession number AF193487_1), rabbit Ndom ACEs N-domain (derived from P 12822), bovine Ndom (Bovine {Bos taunts) ACEs N-domain), mouse Ndom ACEs N-domain (derived from accession number P09470), rat Ndom ACEs N- domain (derived from accession number P4782Q), chick ACE (partial ACE accession number Q10751), dros AnCE (derived from accession number Q10714), dros ACEr (derived from accession number X96913), buffalo fly ACE (derived from accession number Q10715), and silkworm ACE (derived from accession number BAA97657), tick ACE (derived from accession number U62809).

The sequences may also have deletions, insertions or substitutions of amino acid residues, which produce a silent change and result in a functionally equivalent substance. Deliberate amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic -nature of the residues as long as the secondary binding activity- of the substance is retained. For example, negatively charged amino acids include aspartic acid and glutamic acid; positively charged amino acids include lysine and arginine; and amino acids with uncharged polar head groups having similar hydrophilicity values include leucine, isoleucine, valine, glycine, alanine, asparagine, glutamine, serine, threonine, phenylalanine, and tyrosine.

Conservative substitutions may be made, for example according to the Table below. Amino acids in .the same block in the second eolumn and preferably in the same line in the third column-may be substituted for each other:

Homologous substitution (substitution and replacement are both used herein to mean the interchange of an existing amino acid residue, with an alternative residue) may occur i.e. like-for-like substitution such as basic for basic, acidic for acidic, polar for polar etc.. Non-homologous substitution may also occur i.e. from one class of residue to another or alternatively involving the inclusion of unnatural amino acids such as ornithine (hereinafter referred to as Z), diaminobutyric acid ornithine (hereinafter referred to as B), norleucine ornithine (hereinafter referred to as O), pyriylalanine, thienylalanine, naphthylalanine and phenylglycine.

Replacements may also be made by unnatural amino acids include; alpha* and alpha- disubstituted* amino acids, N-alkyl amino acids*, lactic acid*, halide derivatives of natural amino acids such as trifluorøtyr-osme*, p-Cl-phenylalanine*, p-Br- phenylalanine*, p-I-phenylalanine*, L-allyl-glycine*, β-aTanrne*, L-α-amino butyric acid*, L-γ-amino butyric acid*, L-α-amino isoburyrie acid*, L-ε-amino caproic acid , 7- amino-hep.tanoic acid*, Lr-methionine sulfone*^*, L-norleucine*, L-norvaline*, p-nitro-L- phenylalanine*, L-hydroxyproline^#, L-thioproline*, methyl derivatives of phenylalanine (Phe) such as 4-methyl-Phe*, pentamethyl-Phe*, L-Phe (4-amino)^#, L-Tyr (methyl)*, L- Plie (4-isopropyl)*, L-Tiα (l,2,3,4-tetrahydroisoquinolme-3-carboxyl acid)*, L- diaminopropionic acid* andL-Phe (4-benzyl)*. The notation * has been= utilised for the purpose of the discussion above (relating to homologous or non-homologous substitution), to indicate the hydrophobic nature of the derivative whereas # has been utilised to indicate the hydrophilic nature of the derivative, #* indicates amphipathic characteristics.

The term "derivative" or "derivatised" as usedherein includes chemical modification of a ligand - such as .test-compound or a modulator of the N-domain of ACE protein. Illustrative of such chemical modifications would be replacement of hydrogen by a halo group, an alkyl group, an acytgroup or an amino group.

Variant amino acid sequences-may include suitable spacer groups that may be inserted ^"between any two amino acid residues of the sequence including alkyl groups such as methyl, ethyl or propyl groups in addition to amino acid spacers such as glycine or β- alanine residues. A further form of variation, involves the presence of one or more amino acid residues in peptoid form, will be well understood by those skilled in the art. For the avoidance of doubt, "the peptoid form" is used to refer to variant amino acid residues wherein the α-carbon substituent group is on the residue's nitrogen atom rather than the α-carbon. Processes for preparing peptides in the peptoid form are known in the art, for example Simon RJ et al., PNAS (1992) 89(20), 9367-9371 and Horwell DC, Trends Biotechnol. (1995) 13(4), 132-134.

TEST COMPOUND

As used herein, the term "test compound" includes, but is not limited to, a compound which may be obtainable from or produced by any suitable source, whether natural or not.

The test compound may be designed or obtained from a small molecule- library ΌΪ compounds, which may comprise peptides, as well as-other compounds, such as small organic molecules and particularly new lead compounds. By way of example, the test compound may be a natural substance, a biological macromolecule, or an extract made from biological materials - such as bacteria, fungi, or animal (particularly mammalian) cells or tissues, an organic or an inorganic molecule, a synthetic test compound, a semi-synthetic test compound,, a structural or functional mimetic, a peptide, a peptidomimetics, a derivatised test compound, a peptide cleaved from a whole protein, or a peptide synthesised synthetically (such as, by way of example, either using a peptide synthesiser or by recombinant techniques or combinations thereof, a recombinant test compound, a natural or a non-natural test compound, a fusion protein or equivalent thereof and mutants, derivatives or combinations thereof. The test compound may even be a- compound that is a modulator of the N-domain-or C-domain of ACE protein - such as a- known inhibitor ofrthe N-domain or C-domain of ACE proteinr that has been modified in some way e.g. by recombinant DNA techniques or chemical synthesis techniques.

Typically, the test compound will be prepared ^"by recombinant DNA techniques and/or chemical synthesis techniques.

Once a test compound capable of interacting with the N-domain or C-domain of ACE protein has been identified, further steps may be carried out to select and/or to modify the test compounds and/or to modify existing compounds, such that they are able to modulate the N-domain or C-domain of ACE protein. The present invention also relates to a test compound which may be a domain specific compound such as a domain specific inhibitor capable of modulating the activity of the ACE protein in a domain specific manner. That is the compound is capable of modulating the N-domain and/or C-domain of ACE protein.

MODULATING THE ACTIVITY OF ACE

As herein, the term "modulating" refers to preventing, suppressing, inhibiting, alleviating, restoring, elevating, increasing or otherwise affecting the N-domain or C- domain of ACE protein.

The term "modulator of N-domain or C-domain of ACE" may refer to a single ligand or a combination of ligands.

The modulator of the N-domain or C-domain of ACE protein may be an antagonist or an agonist of the N-domain or the C-domain of ACE.

As used herein, the term "agonist" means any ligand, which is capable of interacting (e.g. binding) with N-domain or C-domain of ACE protein and which is capable of increasing a proportion of the N-domain or C-domain of ACE that is in an active form, .resulting in an increased biological response.

As used herein, the term "antagonist" means any ligand, which is capable of interacting (e.g. binding) with N-domain or C=domain df^'ACE protein and- which is capable of decreasing (eg. inhibiting) a proportion of the N-domain or C-domain of ACE that is in an active form, resulting in a decreased biological response.

Preferably, the modulators of the N-domain or C-domain of ACE protein of the present invention are antagonists of the N-domain or C-domain of ACE protein.

The modulator may be an organic compound or other chemical. The modulator may be a compound, which is obtainable from or produced by any suitable source, whether natural or artificial. The modulator may be an amino acid molecule, a polypeptide, or a chemical derivative thereof, or a combination thereof. The modulator may even be a polynucleotide molecule - which may be a sense or an anti-sense molecule. The modulator may even be an antibody.

The modulator of the N-domain or C-domain of ACE protein may be designed or obtained from a small molecule library of compounds, which may comprise peptides, as well as other compounds or small organic molecules.

By way of example, the modulator of the N-domain or C-domain of ACE protein may be a natural substance, a biological macromolecule, or an extract made from biological materials, such as bacteria, fungi, or animal (particularly mammalian) cells or tissues, an organic or an inorganic molecule, a synthetic agent, a semi-synthetic agent, a structural or functional mimetic, a peptide, a peptidomimetic, a derivatised agent, a peptide cleaved from a whole protein, or a peptide synthesised synthetically (such as, by way of example, either using a peptide synthesiser or by recombinant techniques or combinations thereof, a recombinant agent, an antibody, a natural or a non-natural agent, a fusion protein or equivalent thereof and mutants, derivatives or combinations thereof).

Typically, the- modulator of the N-domain- or C-domain of ACE protein will he an organic compound. Typically, the organic compounds will comprise two or more hydrocarb-yl^" groups. Here, the term "hydrocarbyl group" jneans a group comprising at least C and H and may optionally comprise-one or more other suitable substituents. Examples of such substituents may include halo-, alkoxy-, nitro-, an alkyl group, a cyclic- group etc. In addition to the possibility of the substituents^~bemgia cyclic group, a combination of .substituents may form a_cyclic group. If the hydrocarbyl group comprises more than one C then those carbons need not .necessarily be linked to each other. For example, at least two of the carbons may be linked via SL suitable element or group. Thus, the hydrocarbyl group may contain hetero atoms. Suitable hetero atoms will be apparent to those skilled in the art and include, for instance, sulphur, nitrogen and oxygen. For some applications, preferably the modulator of the N- domain or C-domain of ACE protein comprises at least one cyclic group. The cyclic group may be a polycyclic group, such as a non-fused polycyclic group. For some applications, the modulator of the N-domain or C-domain of ACE protein comprises at least the one of said cyclic groups linked to another hydrocarbyl group.

Ihe modulator of the N-domain or C-domain of ACE protein may contain halo groups, for example, fluor-o, chloro, bromo or iodo groups.

The modulator of the N-domain or C-domain of ACE protein may contain one or more of alkyl, alkoxy, alkenyl, alkylene and alkenylene groups - which may be unbranched- or branched-chain.

The modulator of the N-domain or C-domain of ACE protein may be in the form of a pharmaceutically acceptable salt — such as an-acid addition salt or a base salt - or a solvate thereof, including a hydrate thereof. For a review on suitable salts see Berge etal., (1977) J. Pharm. ScL 66, 1-19.

The modulator of the N-domain or C-domain of ACE protein may be a structurally novel modulator.

The modulators of the N-domain or C-domain of ACE protein may be analogues to other known modulators - such as known inhibitors of theJM-domain of ACE protein (for example, snake venom, peptides produced by enzymatic hydrolysis of casein or fish meat protein, or Benazepril, Captopril, Cilazapril, Enalapril,. Fosinopril, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, TrandolapαLand Enalaprilat).

Preferably the inhibitor of the N-domaih or C-domain of ACE protein is Lisinopril (N2-[(S)-l-carboxy-3-phenylprepyl]-L-lysyl-L-proline; also known- as Prinivil or Zestril).

Preferably, the N-domain or C-domain of ACE protein modulators have improved properties over those previously available, for example, fewer side effects - such as cough (e.g. dry, persistent); fever and chills; hoarseness; swelling of face, mouth, hands, or feet; trouble in swallowing or breathing; itching of skin; yellow eyes or skin; dizziness, light-headedness, or fainting; skin rash, with or without itching; fever, or joint pain; abdominal pain, abdominal distention; nausea, or vomiting; chest pain, confusion; irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; weakness or heaviness of legs; headache, diarrhoea; loss of taste; nausea; unusual tiredness and angioedema.

The modulator of the N-domain or C-domain of ACE protein may be a mimetic.

The modulator of the N-domain or C-domain of ACE protein may also be chemically modified.

The modulator of the N-domain or C-domain of ACE protein may be capable of displaying other therapeutic properties;

The modulator of the N-domain or C-domain of ACE protein may be used in combination with one or more other pharmaceutically active agents.

If combinations of active- agents are administered, then these may be administered simultaneously, separately or sequentially.

MIMETIC

As-used herein, the term "mimetic" relates to any chemical including,, but not limited to, peptide, polypeptide, antibody or other organic chemical with-the same qualitative activity or effect as a known- compound. That is, the mimetic is a functional equivalent of a known compound.

STEKEQ-AND GEOMETRIC ISOMERS

Modulators of the N-domain or C-domain of ACE protein may exist as stereoisomers and/or geometric isomers — e.g. they may possess one or more asymmetric and/or geometric centres and so may exist in two or more stereoisomeric and/or geometric forms. The present invention contemplates the use of all of the individual stereoisomers and geometric isomers, and mixtures thereof.

PHARMACEUTICAL SALT Modulators of the N-domain or C-domain of ACE protein may be administered in the form of a pharmaceutically acceptable salt.

Pharmaceutically-acceptable salts are well known to those skilled in the art, and for example include those mentioned by Berge et al, (1977) J. Pharm. ScL, 66, 1-19.

Suitable acid addition salts are formed from acids which form non-toxic salts and include the hydrochloride, hydrobromide, hydroiodide, nitrate, sulphate, bisulphate, phosphate, hydrogenphosphate; acetate, trifluoroacetate, gluconate, lactate, salicylate, citrate, tartrate, ascorbate, succinate, maleate, fumarate, gluconate, formate, benzoate, methanesulphonate, ethanesulphonate, benzenesulphonate and p-toluenesulphonate salts.

When" one or morer acidic moieties are present, suitable pharmaceutically acceptable base addition salts can be formed from bases which form non-toxic salts and include the aluminium, calcium, lithium, magnesium, potassium, sodium, zinc, and pharmaceutically-active amines such as diethanolamine, salts,

A pharmaceutically acceptable salt of a modulator of the N-dbmain or C-domain of ACE protein may be. readily prepared by mixing together solutions of the modulator and the desired acid or base, as-appropriate. The salt may precipitate from solution and be collected by filtration or may be recovered by evaporation of the solvent.

The modulator, of- the. N-domain- or C-domain of ACE protein may exist in polymorphic form.

The modulator of the N-domain- or C-domain of ACE protein may contain one or more asymmetric carbon atoms and- therefore exists in two or more stereoisomeric forms. Where a modulator of the N-domain or C-domain of ACE protein contains an alkenyl or alkenylene group, cis (E) and trans (Z) isomerism may also occur. The present invention includes the individual stereoisomers of the modulator of the N- domain or C-domain of ACE protein and, where appropriate, the individual tautomeric forms thereof, together with mixtures thereof. Separation of diastereoisomers or cis and trans isomers may be achieved by conventional techniques, e.g. by fractional crystallisation, chromatography or H.P.L.C. of a stereoisomers mixture of the modulator of the N-domain or C-domain of ACE protein or a suitable salt or derivative thereof. An individual enaπtiomer of the modulator of Hie N-domain or C-domain of ACE may also be prepared from a corresponding optically pure intermediate or by resolution, such as by H.P.L.C. of the corresponding racemate using a suitable chiral support or by fractional crystallisation of the diastereoisomeric salts-formed'by-reaction of the -corresponding racemate with a suitable optically active acid or base, as appropriate.

The modulator of the N-domain or C-domain of ACE may also include all suitable isotopic variations of the modulator or a pharmaceutically acceptable salt thereof. An isotopic variation of an modulator of the N-domain or C-domain of ACE or a pharmaceutically acceptable salt thereof is defined as one in which at least one atom is replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually found in nature. Examples of isotopes that can be incorporated into the modulator of ACE and pharmaceutically acceptable salts thereof include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulphur, fluorine and chlorine such as ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁷O, ¹⁸O, ³¹P, ³²P, ³⁵S, ¹⁸F and ³⁶Cl, respectively. Certain isotopic variations of the modulator ϋie N-domain or C-domain of ACE and pharmaceutically acceptable salts thereof, for- example, those in which a radioactive isotope such as ³H er ¹⁴C^" is incorporated, are useful- in drug and/or substrate tissue distribution studies. Tritiated, i.e., H, and carbon-14, i.e., C, isotopes are particularly preferred for their ease of preparation and deteetability. Further, substitationrw-ith isotopes such -as deuterium, i.e., ²H, may afford certain therapeutic advantages resulting from greater metabolic stability, for example, increased in vivo half-life or reduced dosage requirements and hence may be preferred in some circumstances. Isotopic variations of the modulator of the N-domain or C- domain of ACE and pharmaceutically acceptable salts thereof of this invention can generally be prepared by conventional procedures using appropriate isotopic variations of suitable reagents.

It will be appreciated by those skilled in the art that the agent may be derived from a prodrug. Examples of prodrugs include entities that have certain protected group(s) and which may not possess pharmacological activity as such, but may, in certain instances, be administered (such as orally or parenterally) and thereafter metabolised in the body to form the modulator of the N-domain or C-domain of ACE which is pharmacologically active.

It will be further appreciated that certain moieties known as "pro-moieties", for example as described in "Design of Prodrugs" by H. Bundgaard, Elsevier, 1985 (the disclosured of which is hereby incorporated by reference), may be placed on appropriate functionalities of the modulator of the N-domain or C-domain of ACE protein. Such prodrugs are also-contemplated^~within the scope of "the invention.

PHARMACEUTICALLY ACTIVE SALT

The modulator of the N-domain or C-domain of ACE protein may be administered as a pharmaceutically acceptable salt. Typically, a pharmaceutically acceptable salt may be readily prepared by using a desired acid or base, as appropriate. The salt may precipitate from solution and be collected by filtration or may be recovered by evaporation of the solvent.

CHEMICAL SYNTHESIS METHODS

The modulator of the N-domain or C-domain of ACE protein of the present invention may be-prepared-by chemical synthesis techniques.

It will be apparent to-those skilled in the art that-sensitive functional, groups may need to he protected and deprotected during synthesis of a compound of the invention. This may "be achieved by conventional- techniques, for example as described in "Protective Groups in Organic Synthesis" by T W Greene and P G M- Wuts, John Wiley and Sons Lac. (1991), and by P.J.Kocienski, in "Protecting Groups", Georg Thieme Verlag (1994).

It is possible during some of the reactions that any stereocentres present could, under certain conditions, be racemised, for example if a base is used in a reaction with a substrate having an having an optical centre comprising a base-sensitive group. This is possible during e.g. a guanylation step. It should be possible to circumvent potential problems such as this by choice of reaction sequence, conditions, reagents, protection/deprotection regimes, etc. as is well-known in the art.

The compounds and salts may be separated and purified by conventional methods.

Separation of diastereomers may be achieved by conventional techniques, e.g. by fractional crystallisation, chromatography or H.P.L.C. of a stereoisomeric mixture of a compound of formula (I) or a suitable salt or derivative thereof. Au individual- enantiomer of a compound of formula (I) may also be prepared, from a corresponding optically pure intermediate or by resolution, such as by H.P.L.C. oFthe corresponding racemate using a suitable chiral support or by fractional crystallisation of the diastereomeric salts formed by reaction of the corresponding racemate with a suitably optically active acid or base.

The N-domain or C-domain of ACE protein, modulators of the N-domain or C- domain of ACE protein or variants_rhomologues, derivatives, fragments or mimetics thereof may be produced using chemical methods to synthesise the N-domain or C- domain of ACE protein or the modulator of the N-domain or C-domain of ACE protein in whole or in part. For example, the N-domain or C-domain peptide or a- modulator of the N-domain or C-domain of ACE protein that is a peptide can be synthesised by solid phase techniques, cleaved from the resin, and purified by preparative high performance liquid chromatography (e.g., Creighton (1983) Proteins Structures And Molecular Principles, WH-Ereeman- and Co, New York NY). The composition of the synthetic peptides may be confirmed-by amino acid analysis or sequencing (e.g., the Edman degradation procedure; Creighton, supm).

Synthesis of peptides (or variants, homologues,. derivatives, fragments or mimetics thereof) may be performed using various solid-phase techniques (Roberge JY et al (1995) Science 269: 202-204) and automated synthesis maybe achieved, for example, using the ABI 43 1 A Peptide Synthesizer (Perkin Elmer) in accordance with the instructions provided by the manufacturer. Additionally, the amino acid sequences comprising the modulator of the N-domain or C-domain of ACE protein, may be altered during direct synthesis and/or combined using chemical methods with a sequence from other subunits, or any part thereof, to produce a variant modulator of the N-domain or C-domain of ACE protein.

CHEMICAL MODIFICATION

The modulator of the N-domain or C-domain of ACE protein may be a chemically modified modulator.

The chemical modification of a modulator of the N-domain or C-domain of ACE protein may either enhance or reduce interactions between, the modulator of the N- domain or C-domain of ACE protein and the target - such as hydrogen bonding interactions, charge interactions, hydrophobic interactions, van der Waals interactions or dipole interactions-.

hi one aspect, the modulator of the N-domain or C-domain of ACE protein may act as a model (for example, a template) for the development of other compounds.

PHARMACEUTICAL COMPOSITIONS

The components may be administered alone but will generally .be administered as a pharmaceutical composition - e.g. when the components are in a mixture with a .suitable pharmaceutical excipient, diluent or- carrier selected with regard to the intended route of administration and standard pharmaceutical practice^".

-For example, the components can be administered in the form ofLtablets, capsules, ovules, elixirs, solutions or suspensions,- which may contain ftavouring-or colouring agents, for immediate-, delayed-, modified-, sustained^"-, pulsed- or controlled-release applications.

If the pharmaceutical is a tablet, then the tablet may contain excipients such as macrocrystalline cellulose, lactose, sodium citrate, calcium carbonate, dibasic calcium phosphate and glycine, disintegrants such as starch (preferably corn, potato or tapioca starch), sodium starch glycollate, croscarmellose sodium and certain complex silicates, and granulation binders - such as polyvinylpyrrolidone, hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC), sucrose, gelatin and acacia. Additionally, lubricating agents - such as magnesium stearate, stearic acid, glyceryl behenate and talc may be included.

Solid compositions of a similar type may also be employed as fillers in gelatin capsules. Preferred excipients in this regard include lactose, starch, a cellulose, milk sugar or high molecular weight polyethylene glycols. For aqueous suspensions and/or elixirs, the modulator ofthe N-domain or C-domain of ACE protein may be combined with various sweetening or flavouring agents, colouring matter or dyes, with emulsifying and/or suspending agents^' and with diluents such as water, ethanol, propylene- glycol and glycerin, and combinations thereof.

The routes for administration (delivery) may include, but are not limited to, one or more of oral (e.g. as a tablet, capsule, or as an. ingestable solution), topical, mucosal (e-.g. as a nasal spray or aerosol for inhalation), nasal, parenteral (e.g. by an injectable form), gastrointestinal, intraspinal, intraperitoneal, intramuscular, intravenous, intraventricular, intrauterine, intraocular, intradermal, intracranial, intratracheal, intravaginal, intracerebroventricular, intracerebral, subcutaneous, ophthalmic (including intr-avitreal or intracameral), transdermal, rectal, buccal, τaginal, epidural, sublingual.

Pharmaceutical compositions ofthe present invention- may comprise a therapeutically effective amount of the N-domain of ACE protein, one or more modulators of the N- demain of ACE -protein, one or more modulators of the C-domain of ACE. protein or combinations thereof.

The pharmaceutical compositions may be for human or animal usage in human and veterinary medicine and will typically comprise any one or more of a pharmaceutically acceptable diluent, carrier, or excipient. Acceptable carriers or diluents for therapeutic use are well known in the pharmaceutical art, and are described, for example, in Remington's Pharmaceutical Sciences, Mack Publishing Co. (A. R. Gennaro edit. 1985). The choice of pharmaceutical carrier, excipient or diluent can be selected with regard to the intended route of administration and standard pharmaceutical practice. The pharmaceutical compositions may comprise as - or in addition to - the carrier, excipient or diluent any suitable binder(s), lubricant(s), suspending agent(s), coating agent(s), solubilising agent(s).

Preservatives, stabilisers, dyes and even flavouring agents may be provided in the pharmaceutical^" .composition. Examples of preservatives include sodium benzoate, sorbic acid and esters of p-hydroxybenzoic acid. Antioxidants and suspending agents may be also used.

There may be different composition/formulation requirements dependent on the different delivery systems. -Byway of example, the pharmaceutical composition of the present invention may- be formulated to-be administered using a mini-pump or by a mucosal route, for example, as a nasal spray or aerosol for inhalation or ingestable solution, or parenterally in which the composition is formulated by an injectable form, ^■for -delivery, by, for example, an intravenous, intramuscular or subcutaneous route. Alternatively, the formulation may be designed to be administered by a number of routes.

If the modulator of the N-domain or C-domain of ACE protein is to be administered mucosally through the gastrointestinal mucosa, it should be able to remain stable during, transit -though the gastrointestinal tract; for example, it should be resistant to proteolytic degradation,_stable at acid pH and resistant to the detergent effects of bile.

Where

the pharmaceutical compositions may be adrninistered by -inhalation, in the form- of a suppository or pessary, topically in the form of a lotion, solution,, cream, ointment or dusting-powder, by use of a skin patch, orally in the form of tablets containing excipients such as starch or lactose, or in capsules or ovules either alone or in admixture with excipients, or in the form of elixirs, solutions or suspensions containing flavouring or colouring agents, or the pharmaceutical compositions can be injected parenterally, for example intravenously, intramuscularly or subcutaneously. For parenteral administration, the compositions may be best used in the form of a sterile aqueous solution which may contain other substances, for example enough salts or monosaccharides to make the solution isotonic with blood. For buccal or sublingual administration the compositions may be administered in the form of tablets or lozenges which can be formulated in a conventional manner. The modulators of the N-domain or C-domain of ACE protein may be used in combination with a cyclodextrin. Cyclodextrin molecules are known to form inclusion and non-inclusion complexes with drug molecules. Formation of a drug- cyclodextrin complex may modify the solubility, dissolution rate, bioavailability and/or stability property of a drug molecule. Drug-cyclodextrin complexes are generally useful for most dosage forms and administration routes. As an alternative to direct complexation with the drug the- cyclodextrin may be used as an auxiliary- additive, e.g. as a carrier, diluent or solubiliser. Alpha-, beta- and gamma- cyclodextrins are most commonly used and- suitable examples are. described in WO- A-91/11172, WO-A-94/02518 and WO-A-98/55148.

If the modulator of the N-domain or C-domain of ACE is a protein, then said protein modulator may be prepared in situ in the subject being treated. In this respect, nucleotide sequences encoding said protein may be delivered by use of non- viral techniques (e.g. by use of liposomes) and/or viral techniques (e.g. by use of retroviral vectors) such that the said protein is expressed from said nucleotide sequence.

DOSE LEVELS

Typically, a physician will determine the- actual dosage which will be most suitable for an individual subject. The- specific dose level- and frequency of dofsage for any particular patient may be- varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability-and length of action of that compoundpthe age, body weight, general health-, sex, diet, mode .and tune of administration, rate of excretion, drug combination, the severity of the particular condition, and the individual undergoing therapy.

The modulators of the N-domain of ACE protein or the C-domain of ACE protein may be administered separately, concomitantly or sequentially.

FORMULATION The component(s) may be formulated into .a pharmaceutical composition, such as by mixing with one or more of a suitable carrier, diluent or excipient, by using techniques that are known in the art.

VECTOR

Aspects of the present invention relate to a vector comprising a nucleotide sequence - such as a nucleotide sequence encoding the N-demain or the C-doraain of ACE protein or a modulator of the N-domain or the C-domain of ACE protein - administered to a subject.

Preferably, the N-domain or the C-domain of ACE and/or the modulator are prepared and/or delivered using a genetic vector.

It is well known in the art, that a vector is a tool that allows or facilitates the transfer of information from one environment to another. In accordance with- the present invention, and by way of example, some vectors used in recombinant DNA techniques allow entities, such as a segment of DNA (such as a heterologous DNA segment, such as a heterologous cDNA segment), to be transferred into a host and/or a target cell^" for the purpose of replicating the -vectors comprising nucleotide sequences, and/or expressing the proteins encoded by the nucleotide sequences-. Examples of vectors used in recombinant DNA techniques-include, but are not limited to, plasmids, -chromosomes, artificial chromosomes or viruses.

The term "vector-¹ includes expressien vectors such_as transfection vectors, transduction vectors or transformation vectors".

The term "expression vector" means a construct capable of in vivo or in vitrolex vivo expression.

The terms "transfection vectors", "transduction vectors" or "transformation vectors" describe different constructs capable of being transferred from one organism to another of from one species to another. REGULATORY SEQUENCES

In some applications, nucleotide sequences are operably linked to a regulatory sequence which is capable of providing for the expression of the nucleotide sequence, such as by a chosen host cell. By way of example, a vector comprising the N-domain or the C-domain of ACE nucleotide sequence is operably linked to such a regulatory sequence i.e. the vector is an expression vector.

The term "operably linked" refers to a juxtaposition wherein the components described are in a relationship permitting them to function in their intended manner. A regulatory sequence "operably linked" to a coding sequence is ligated in. such a way that expression of the coding sequence is achieved under conditions compatible with the control-sequences.

The term "regulatory sequences" includes promoters and enhancers and other expression regulation signals.

The term "promoter" is used in the normal sense of the art, e.g. an RNA polymerase binding site.

Enhanced expression of a nucleotide sequence, for example, a nucleotidσ sequence encoding the N-domain or the C-domain of ACE .protein.- may also be achieved by the selection of heterologous regulatory regions, e.g.jpromoter, secretion leader and terminator regions, which serve to increase expression and, if desired, secretion levels of the protein of interest from- the chosen .expression host and/or to provide for-the inducible control of the expression of theJST-domain or the. C-domain of ACE^" protein. In eukaryotes, polyadenylation sequences may be operably connected to the C- terminus of the nucleotide sequence of the N-domain or the C-domain of ACE protein.

Preferably, the N-domain or the C-domain of ACE protein nucleotide sequence is operably linked to at least a promoter. Aside from the promoter native to the nucleotide sequence described herein, other promoters may be used to direct its expression. The promoter may be selected for its efficiency in directing the expression of the N-domain or the C-domain of ACE nucleotide sequence in the desired expression host. 5

In another embodiment, a constitutive promoter may be selected to direct the expression of the N-domain or the C-domain of ACE nucleotide sequence of the present invention. Such an expression construct may provide additional advantages since it circumvents the need to culture the expression hosts on a medium containing 10 an inducing substrate.

Hybrid promoters may also be used to improve inducible regulation of the expression construct.

15 The promoter can additionally include features to ensure or to increase expression in a suitable host- For example, the features can be conserved regions such as a Pribnow- Box or a TATA box. The promoter may even contain other sequences to affect (such as to maintain, enhance, decrease) the levels of expression of the N-domain or C- domain of ACE nucleotide sequence. For example, suitable other sequences include

20 the Shl-intron or an ADH intron. Other sequences include inducible elements - such as temperature, chemical^" light or stress inducible elements. Also, suitable elements to- enhance transcription or translation may be-present

EXPRESSION VECTOR:

^"25

Preferably, nucleotide sequences - such as nucleotide sequences encoding the N- domain or C-domain of ACE or modulators of the N-domain or C-domain of ACE - are inserted into a vector that is operably linked to a control sequence that is capable of providing for the expression of the coding sequence by the host cell.

30

Nucleotide sequences produced by a host recombinant cell may be secreted or may be contained intracellularly depending on the sequence and/or the vector used. As will be understood by those of skill in the art, expression vectors can be designed with signal sequences, which direct secretion of the nucleotide sequence through a particular prokaryotic or eukaryotic cell membrane.

The expression vector may be pEE14 N-domain which encodes the N domain of human ACE and is truncated in the interdomain linker region.

Preferably, the expression vectors are stably expressed in CHO-Kl cells as described previously (Efflers et al, (1996) Biochemistry 65, 9549-9559).

FUSION -PROTEINS

The N-domain or C-domain of ACE protein or a modulator of the N-domain or C- domain of ACE protein may be- expressed as a fusion jprotein .to- aid extraction and purification and/or delivery of the modulator of the N-domain or C-domain of ACE or the N-domain or C-domam of ACE protein to an individual- and/or to facilitate the development of a screen for modulators of the N-domain or C-domain of ACE protein.

Examples of fusion protein_parmers include gkitathione-S-transferase (GST), 6xHis, GAL4 (DNA binding and/or transcriptional activation domains) and β-galactosidase.

It may also be convenient to include _a- proteolytic cleavage site between the- fusion- protein partner and the protein sequence of interest to. allow removal of fusion protein sequences. Preferably, the "fusion protein will not hinder-Λe activity of the protein of interest.

The fusion protein may comprise an antigen or an antigenic determinant fused to the substance of the present invention. In this embodiment, the fusion protein may be a non-naturally occurring fusion protein comprising a substance, which may act as an adjuvant in the sense of providing a generalised stimulation of the immune system. The antigen or antigenic determinant may be attached to either the amino or carboxy terminus of the substance. ORGANISM

The term "organism" in relation to the present invention includes any organism that could comprise the N-domain or C-domain of ACE protein and/or modulators of the N- domain or- C-domain of ACE protein. Examples of organisms may include mammals, fungi, yeast, plants or bacteria.

Preferably, the organism is as vertebrate^~or a mammal. More preferably,, the organism is a human.

TRANSFORMATION

As indicated earlier, the host organism can b& a prokaryotic or a eukaryotic organism. Examples of suitable prokaryotic hosts include E. coli and Bacillus subtilis-. Teachings on the transformation of prokaryotic hosts are well documented in the art, for example see Sambrook et al., (Molecular Cloning: A Laboratory Manual, 2nd edition, 1989, Cold Spring Harbor Laboratory Press) and Ausubel et al., Current Protocols in Molecular Biology (1995), John Wiley & Sons, Inc. Examples of suitable eukaryotic hosts include mammalian cells.

If a prokaryotic. host is used then the nucleotide sequence - such as the N-domain of ACE nucleotide -sequence - may need to be suitably modified-hefore transformation - sueh as by removal of introns.

Thus, the present invention also relates to the transformation of a-Jiost cell with a nucleotide sequence - such as those coding for the N-domain or C-domain of ACE protein or a modulator of the N-domain or C-domain of ACE protein. Host cells transformed with the nucleotide sequence may be cultured under conditions suitable for the expression and recovery of the encoded protein from cell culture. The protein produced by a recombinant cell may be secreted or may be contained intracellularly depending on the sequence and/or the vector used. As will be understood by those of skill in the art, expression vectors containing coding sequences can be designed with signal sequences which direct secretion of the coding sequences through a particular prokaryotic or eukaryotic cell membrane. Other recombinant constructions may join the coding sequence to nucleotide sequence encoding a polypeptide domain, which will facilitate purification of soluble proteins (Kroll DJ et al., (1993) DNA Cell Biol 12:441--53) e.g. 6-His or Glutathione-S-transferase.

TRANSFECTION

Vectors comprising for example, the nucleotide sequence coding for the N-domain or C-domain of ACE protein, may be introduced into- host cells-, for example, mammalian cells, using a variety of methods.

Typical transfection methods, include .electroporation, DNA biolistics, lipid-mediated transfection, compacted DNA-mediated transfection, liposomes, immunoliposomes, Jipofectin, cationic agent-mediated, cationic facial amphiphiles (CFAs) {Nature Biotech. (1996) 14, 556), multivalent cations such as spermine, cationic lipids or polylysine, 1, 2,-bis (oleoyloxy)-3-(trimethylammonio) propane- (DOTAP)-cholesterol complexes (Wolff and Trubetskoy- (1998) Nature Biotech. 16, 421) and combinations thereof.

Uptake of nucleic acid constructs by mammalian cells- is enhanced by several known transfection techniques for .example those including the use of transfection agents.

Example, of these agents include cationic agents (for example calcium phosphate and

DEAE-dextr-an) and lipofectants (for example lipofectam™ and transfectam™).

Typically,- nucleic acid constructs are mixed with the transfection agent to produce a composition.

Such methods are describedJn many standard laboratory manuals - such.as Sambrook et al., Molecular Cloning: A Laboratory Manual, 2d ed. (1989) Cold Spring Harbor

Laboratory Press, Cold Spring Harbor, N. Y.

GENERAL RECOMBINANT DNA METHODOLOGY TECHNIQUES

The present invention employs, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA and immunology, which are within the capabilities of a person of ordinary skill in the art. Such techniques are 1

explained in the literature. See, for example, J. Sambrook, E. F. Fritsch, and T. Maniatis, 1989, Molecular Cloning: A Laboratory Manual, Second Edition, Books 1-3, Cold Spring Harbor Laboratory Press; Ausubel, F. M. et al, (1995 and periodic supplements; Current Protocols in Molecular Biology, ch. 9, 13, and 16, John Wiley & Sons, New York, N. Y.); B. Roe. J. Crabtree, and A. Kahn, 1996, DNA Isolation and Sequencing: Essential Techniques, John Wiley & Sons; J. M. Polak and James O 'D. McGee, 1990, In Situ Hybridization: Principles and Practice,; Oxford University Press; M. J. Gait (Editor), 1984, Oligonucleotide Synthesis: A Practical Approach, M Press; and, D. M. J. Lilley and J. E. Dahlberg, 1992, Methods of Enzymohgy: DNA Structure Part A: Synthesis and Physical Analysis of DNA Methods in Enzymelogyr Academic Press. Each of these general texts is herein ineorporated by reference.

DESCRIPTION OF THE DRAWINGS

Figure 1. (A) Overall structure of the N-domain with the zinc ion in green, the chloride ion in red and the oligosaccharides in pink. (B) Superposition of the N domain (turquoise) and tACE (pink) with the zinc ion in green. (C) Backbone coloured according to thermal vibration (B factor) with blue for the lowest B factors and red for the highest (D) Surface diagram showing the lid (dark blue), N-lmked glycans (green) and the protruding surface_patch (pink) -comprising the linker and the flexible loop.

Figure 2. (A) Model of the possible_^domain orientation of ACE. The Ν-terminus and C-terminal linker of two Ν-domains (grey) were overlapped and- tACE (pink) superimposed^". Sugars moieties visible in the Ν-dbmain. and tACE structures are .shown in green, and Ν-glycosylation sequons where no_sugar was observed have been marked by a hypothetical sugar in yellow. The zinc ion in -each domain is in green. (B) Close up of the Ν domain linker and flexible loop (grey). (C) Pink domain lid showing the residues that might be involved in the inter-domain interaction. Charged residues on the C-terminal Hd are shown in red (negative) and blue (positive) with the sugar linked asparagine shown in green. Charged and sugar linked residues are marked by the same colours on the Ν-domain ACE, but their side chains are not visible in the structure. Figures 3. (A) Close up of the active site of the N-domain ACE (blue with white residues) and tACE (pink with purple residues) with the zinc ion in green and the conserved chloride ion in red. Lisinopril is shown in white/purple and the differing residues between the N- and C-domains shown in ball and stick at the top of the picture. (B) Close up of the minimally glycosylated N-domain active site (blue) with a model of RXP407 (yellow) overlapping the water molecule (grey) adjacent to Tyr 369. Residues differing between the N- and C-domains in the S₂ subsite are also shown in ball and^" stick along with the conserved^' residues of the S₁ subsite that- interact with lisinopril. Residues conserved between the N- and C- domains are- shown in white, N-domain residues shown in blue and C-domain residues- shown in pink. The zinc ion is shown in green.

Figure 4. Sequence alignment of the sACE N domain with tACE and ACE2. Helices are highlighted in yellow and strands in blue. The linker region is shown in pmk. Helices are numbered sequentially whether cc or 3io, and 3₁₀ helices are shown with red -letters. Chloride I coordinating residues are boxed in dark blue, chloride II in black, and the zinc binding motif in red.

Table 1. Crystallographic Data

Table 2. Active site residues that differ between the N- and C domaiήs-(C domain numbering is as. for tACE).

TaTSIe A. Structure co-ordinates of N-domain of ACE protein.

Table B. Structure co-ordinates of N-domain of ACE protein complexed with lisinopriL

The invention will now be further described by way of Examples, which are meant to serve to assist one of ordinary skill in the art in carrying out the invention and are not intended in any way to limit the scope of the invention.

EXAMPLES Example 1

Materials & Methods

Construction of Expression Vectors

An N-domain construct Leu 1-Asp 629 (D629) cloned into the vector pECE (a kind gift from Sergei Danilov) and encoding the first 629 residues of somatic ACE, was subcloned into pBlueScript using the restriction endonucleases Xbal and EcoRI: The fragment was then sequenced to verify that the correct fragment was cloned. D6Z9 was then again subcloned into pcDNA3.1(+) using the same restriction enzymes. This N-domain construct was then introduced into the CHO cell- glutamine synthetase (GS) expression vector pEE14 using the restriction endonucleases HindIII and Xbal. The identity of the construct and its correct orientation was confirmed via restriction enzyme digests and further sequencing. The new expression vector was termed jpEE N-domain.

Cell Culture and-Transfections

CHO-Kl cells were co-transfected with pEE14-N-domain and pSV2neo (10:1). Gensticin (G418) (Sigma) resistant clones expressing soluble N-domain were further selected for resistance to methionine sulfoximine (MSX) (Yu et al., 1997). Cells stably expressing the- N-domain were grown in Glasgow Minimum Essential Medium (GMEM) supplemented with 10%. dialysed foetal calf serum (Grbco BRL) and 20μM MSX. When_ confluent growth- medium- was- changed to 1% dialysed -FCS, 0.05% aibumax I (Gibco BRL), 20μM MSX and 1.5IΏM N-butyldeoxynojirimycin (NB- DNJ) (Toronto Research Chemicals mcΩ69-1000 Lot 14-EG-91-1 and B691000 12- Cf-146-2).

Construct purification Medium containing recombinantly expressed soluble N-domain (N-domain of ACE protein) was harvested and purified in tandem over a protein-G Agarose (Sigma) column followed by an N-domain specific monoclonal antibody (5C5) protein G Agarose column. N-domain was eluted with 5OmM ethanolamine pH 11.5. The eluted solution was then dialysed against 5mM HEPES pH 7.5, O.lmM PMSF and concentrated in a 3OkDa Amicon concentrator at 1000-2000 g and 4°C to a concentration of 10mg/ml, and stored at 4°C.

Western Blot Analysis The N-domain of ACE protein was detected and its purity assessed by Western Blot analysis using 10% SDS-PAGE and transferred on nitrocellulose membrane (Hybond- C, Amersham). The membrane is probed with N-domain specific monoclonal antibody (5C5) and developed with using the ECP chemiluminescent kit (Amersham) and visualised on autoradiographic fi-lm according to the manufacturer's instructions.

Crystallisation and X-ray diffraction data collection lμl of the purified N-domain of ACE protein at 4mg/ml was mixed with lμl reservoir solution (Q.2M" lithium sulphate, 0.1M_ sodium acetate; pH 4.9, lOμM zinc sulphate, 15% polyethylene glycol 4000) and suspended above the reservoir as a hanging drop at 16°C. Crystals grew within 1-2 weeks.

A single crystal was cryocooled (100 K) using reservoir solution plus 25% glycerol as a cryoprotectant. Diffraction data to 3.0 A were collected on station PX14.1 of the synchrotron radiation source (Daresbury, U.K.). using a Quantum 4 eharge-coupled- device detector (Area- Detection Systems, Poway, CA). The data were processed and scaled by using the HKL2000 software package (HKL Research, Chariottesville, VA) (Otwinowski, WT Oscillation data reduction -program, in Proceedings of the CCP4 weekend 56-62 (Daresbury Laboratory, Wamngton, UK, 1993). The symmetry and systematic absences were consistent with the C222_\ space group (unit εel-1 dimensions, a = 1-01.12 A; 5 = 211.32 A; and c = 171.27 A) with two proteins per asymmetric unit. The crystals contained ~54% solvent. Data reduction was carried out by using the CCP4 program TRUNCATE (CCP4. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-763 (1994)).

The structure of the N-domain was solved with the program MOLREP (Vagin, A. & Teplyakov, A. An approach to multi-copy search in molecular replacement. Acta Crystallogr. D56, 1622-1624 (2000)) using a homology model of the N-domain based on the tACE structure (protein data bank entry 1O8A) as a search model. Initial refinement was performed using REFMAC Murshudov, G.N. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr.

D53, 240-255 (1997) through the CCP4i interface (CCP4. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-763 (1994)). 4% of reflections was kept aside for iϊfree calculation (Brϋnger, A.T. Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature 355, 472-475 (1992)).

A large part of the C terminal region not present in the tACE structure could be built after the first round of refinement usingihe program Coot (Bmsley, P. & Cowtaa, K.

Coot: Model building tools for molecular graphics. Acta Crystallogr. 60, 2126-2132 - (2004)). Further rounds of refinement and model building allowed the building of the

N terminus and the addition- of water, carbohydrate and glycerol molecules plus an acetate ion. Final refinement was done using the CNS suite (Brϋnger, A.T. et al.

Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D54, 905-921 (1998)).

Sequence "alignment of the sACE N domain with tACE .and ACE2 is shown in Figure

4.

The N-domain/lisinopril inhibitor complex - 4mg/ml of purified N-domain was incubated with 5mM lisinopril for 5 hours at A⁵C lμl N-domain with lisinopril was mixed with lμl reservoir solution (0.2M lϊtHium sulphate, Θ.1M sodium acetate, pH 4;9, TOμM zinc sulphate, 18% polyethylene glycoL 4000) and suspended- above the- reservoir as a hanging drop at 16°C? Crystals grew within 1-2 weeksJn the-same form- as the minimally glycosylated¹ N-domain of ACE protein. Single crystal consistent with the C222_\ space group (unit cell dimensions-, a = 101.32 A; b = 211.90^"A; and c = 171.03 A). Diffraction data to 2.8 A were collected as for the minimaily glycosylated N-domain data set. The data were processed with MOSFLM (Leslie, A.G.W. Recent changes to the MOSFLM package for processing film and image plate data. Joznt CCP4+ESF-EAMCB Newsletter on Protein Crystallography 26(1992)), scaled with SCALA (CCP4. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-763 (1994)) and data reduction carried out by TRUNCATE (CCP4. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-763 (1994)). Refinement (with 2.3% of the reflection kept for the iϊfree calculation) of the minimally glycosylated N-domain structure with the CNS suite (Brunger, A.T. et al. Crystallography & NMR system: A new software suite for macromolecular structure , determination. Acta Crystallogr. D54, 905-921 (1998)) showed clear difference density for the lisinopril, which was modelled with the program Coot (Emsley, P. & Cowtan, K. Coot: Model building tools for molecular graphics. Acta Crystallogr. 60, 2126-2132 (2004)), along with a few water, carbohydrate, glycerol molecules and an acetate ion.

The atomic coordinates have been deposited with the Protein Data Bank, www.rcsb.org, and the accession codes are 2C6F and 2C6N for the minimally glycosylated and lisinopril complexes for sACE N-domain respectively..

All crystals are isomorphous.

Example 2

Overall structure of the N-dβmain - The N-domain was crystallised with two molecules per asymmetric unit. The overall fold consists of a mainly helical secondary structure, with the same topology as tACE. The N-domain has the ellipsoid shape with a central groove dividing- it into two subdomains,-one containing theN-terminal lid that covers the central binding cavity. There are 27 helices, of which 1-8-of them are α helices, 5 are short 3- helices and 4 are -mixed (Woodman, Z.L. et_al., The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.. Biochem J. 389, 739-744 ^'(2005)). There are also 6 short β-strands. The structures of both molecules in the asymmetric are very similar with a root mean square deviation for the Ca. atoms of 0.50A. Analysis of the Ramachandran plot using the program PROCHECK shows that 94% of the residues lie in the most favoured region, with none in the disallowed region (Laskowski, R.A., MacArthur, M. W., Moss, D. S. & Thronton, J.M. PROCHECK -A program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283-291 (1993)). Both termini are well 61

ordered with all the residues (1-612) being modelled for molecule A and only the N- terminal residue missing in molecule B.

The catalytic zinc ion was observed at the active site and one chloride, equivalent to chloride 2 of tACE, adjacent to Arg500. There are ten putative N-glycosylation sites on the human N-domain protein and Fourier difference density was observed at five of these sites in our structure (Figure 1(A)). Seven N-acetyl glucosamine residues were modelled on molecule A at asparagines 25, 45, 117, 289 and 480, and six on molecule B at residues 25, 45, 117 and 480. A mannose residue was also modelled on both molecules at the end of the disaccharide at Asn25. Although the "B-factors for these- sugars are- high, they are modelled on the basis of clear difference density, at least for the ring portions. Twentyfive water molecules were modelled by visual inspection" and a glycerol molecule was modelled on the surface of each molecule adjacent to Glu219. Three acetate molecules were also modelled, one on the surface next to the symmetry axis and one in each of the active sites adjacent to Lys489, where a carboxyalanine was modelled in the tACE structure (Natesh, R., Schwager, S.L.U., Sturrock, E.D. & Acharya, K.R- Crystal structure of the human angiotensin- converting enzyme-lisinopril complex. Nature 421, 551-554 (2003)). We attempted to model N-carboxyalanine at this position however the density-was smaller in the N domain structure.

The N-domain protein was also crystallised in the presence of 5mM lisinopril, for which clear difference, density was observed upon refinement with the minimally glycosylated N-dømain structure. The overall structure is as the minimally glycosylated N-domaiπ, although the lack of completeness in the data results in poorly defined density for the first 30-residues^~of the N-termiπus. The lisinopril is bound at- the active site in the- same position and conformation as observed for tACE (Natesh, R., Schwager, S.L.U., Sturrock, E.D. & Acharya, K.R. Crystal structure of the human angiotensin-converting enzyme-lisinopril complex. Nature 421, 551-554 (2003)). Four N-acetyl glucosamine residues each were modelled on both molecules at asparagines 25, 117, and 480. Nineteen water molecules, two glycerols and one acetate ion were modelled. The acetate ion was modelled near the symmetry axis and the two the glycerols at equivalent surface positions on the two molecules, similar to as observed in the minimally glycosylated structure. Comparison of the N and C domains

The N- and C- domains of somatic ACE have ~60% sequence identity and hence share the same overall topology as well as the highly conserved zinc binding motif at 5 the active site (see figure x which, will be a sequence alignment). The- most easily observable difference between the N- and C- domains (based on tACE) when superimposed (Figure 1(B)) is the extra length of the N- domain at the N- terminus and the C terminus, which includesiiie inter-domain linker. The N-terminus of the N domain protein, whilst having higher than average B factors, is well defined and 10 packs against helix 3. Also, the loop between helices 19 and 20 (residues 409-417) that wasjαot visible, in the tACE. structure, Is.- well defined. Three other flexible loops,, between helices 3 and 4, strands 1 and 2 and strand 6 and helix 23, show small differences between the domains.

•15 The. N-domain has been observed to be activated at lower chloride- concentrations and to a lesser extent than the-C-domain (Wei, L., Clauser, E., Alhenc-Gelas, F. & Corvol, P. The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J. Biol Chem. 267, 13389-13405 (1992)). Consistent with this is the observation of only one chloride bound to the N domain,

20 rather than the two observed for tACE. The chloride ion is observed Bt the identical site as chloride II in tACE, bound between Tyr 202 and Arg 5Θ0. At the equivalent position to the tACE chloride I site, a crucial arginine is substituted by a-histidine in the N-domain. Interestingly, ACE2, which -was also only observed to bind one chleride ion in the .crystal structure, binds chloride in the equivalent position- to

25 .chloride I in tACE.

The domain arrangement ofsACE

The complex kinetics of the somatic ACE catalysis is partly due to the presence of an active site in both the N and C domains and also the potential for interaction between 30 them. The N-and C-domains of sACE are joined by a linker that is susceptible to proteolysis and is assumed to be partly flexible (Sturrock, E.D., Danilov, S.M. & Riordan, J.F. Limited proteolysis of human kidney angiotensin-converting enzyme and generation of catalytically active N- and C-terminal domains. Bio chem, Biophys. Res. Com. 236, 16-19 (1997)). The inclusion of the linker in the N-domain construct allowed us to visualise this region for the first time. The majority of the linker (residues 602-612) was well defined in the electron density map after the first couple of rounds of refinement and was built into the model without ambiguity. The first part of the linker appears to be rigid in our model and is held in place by a hydrogen bond between Tyr607 and Glul61. The last four residues are more flexible as they have high B factors and their side chains are not visible (Fig 1(C)). They form a prominent surface patch, away from the core of the N domain, with a very flexible loop that is anchored by the disulphide bond between Cysl28 and Cysl36 (Fig 1(C)-(D)). Although this flexible loop is on the symmetry axis, neither its nor the linker's conformation appear to be involved in- any crystal packing interactions. Hence it is most likely that the N-terminus of the C-domain would interact withJhis patch, and that it could adapt its conformation to one or more arrangements.

There is some evidence that only one domain of sACE is capable of catalysis at one time and that the N-domain may be a negative regulator of the C domain Andύjar- Sanchez, M., Camara-Artigas, A. & Jara-Perez, V. A calorimetric study of the binding of lisinopril, enalaprilat and captopril to angiotensin-converting enzyme. Biophys. Chan. Ill, 183-189 (2004); Binevski, P.V., Sizova, E.A., Pozdnev, V.F. & Kost, O.A. Evidence for the negative cooperativϋy of the two active sites within bovine somatic angiotensin-converting enzyme. FEBS Lett. 550, 84-88 (2003); Woodman, Z.L. et al., The N domain of somatic angiotensin-converting enzyme negatively- regulates ectodomain shedding and catalytic activity. Biochem J. 389, 239-744^" (2005)). As the flexible region-of the linker appears to be short, then it suggests-that the N- domain would interact with-the-N-terminaLlid region of the-C- domain. The lid region comprise the three (largest) N terminal α-helϊces in both the N- and C- domains- that partly covers the substrate channel- (Natesh, R., Schwager, S.L.U., Sturrock, E.D. & Acharya, K.R. Crystal structure of the human angiotensin- converting enzyme-lisinopril complex. Nature 421, 551-554 (2003)). It is thought that a change in conformation of the lid may be necessary for entry of the substrate and might also contribute to the substrate specificity of the domains. The interaction of the N-domain with the C-domain lid might reduce the flexibility of this region to regulate the entry of substrate to the C-domain active site or even to form a surface that partially blocked the cavity opening. By contrast, the position of the linker ensures that the C-domain is unlikely to interact with the lid region of the N-domain, although it could block the product channel.

The specific interactions between the domains are not obvious, however, particularly as the terminal three residues of the linker are not available in our structure. Furthermore, several side chains on the linker and the flexible loop, which one might assume to play a part in the interaction, are disordered and not visible. We know from the sequence, however, that the flexible loop contains a positively charged lysine, and the linker, three negatively charged residues. These may interact with some of the charged residues protruding from the C-domain lid. The N- and C-domain lids have a different shape, size (due to the .extra N-terminal residues) and charge distribution. These differences have been suggested to have a link to the substrate specificity of the two domains, but it seems likely that the shape and charge of the C-domain lid will also influence its interaction with the N-domain linker.

Based on this analysis, and the conformation of the linker, we propose a tentative domain arrangement for sACE. We suggest that the inter-domain linker could pack against the lid of the C-domain, in a similar manner to how the extra N terminal residues of the N domain, pack against the N domain lid. To visualise this, two N domains were overlapped with the N-terminus of one overlaying the linker of the other (allowing for the missing 3 residues), and then the C-domain (using tACE) was superimposed (Fig 2(A)). The initial arrangement caused the C-doma^"in to overlap the flexible loop, suggesting thatthis loop might mould to ihe-C-domain. Allowing free rotation around the linkerqproduced ajnodel from which it was .easier to observe the residues that could be involved in the- interactioiL. Figure 2(B) shows the charged residues on the N- and C-domains which may help form interactions between them. To complicate matters further, though, there is an N-glycosylation sequon on the flexible loop of the N-domain and the top part of the C-domain lid (Fig 2(A)), suggesting that inter-domain interactions and movements may be mediated or aided by sugars.

Binding of Lisinopril and specificity

The lisinopril bound to the active site was clearly defined, despite the poor electron density map in some other regions of the structure. The binding followed the same orientation as observed for tACE with the central carboxylate coordinating the zinc ion and the phenyl group pointing up towards the lid. The active site residues and the lisinopril molecules for the two structures superimpose well (r.m.s. deviation for Ca atoms, 0.31A) with nearly all the lisinopril binding residues conserved in the N- domain. tACE GIu 162, which interacts electrostatically with the amine on the lysyl side chain, is replaced by Asp 140 in the N-domain away from the Pl' group (Fig 3(A)). Asp 377 of tACE, which forms water mediated interactions with the lysyl group, is also not conserved in the N domain and is replaced by Gln355. Gln355 could potentially form a hydrogen bond with the lysyl group of lisinopril, although this does not appear to be the case in our structure as it is about 4A away. However, it might form water mediated interactions, but water molecules were not visible due "to limited resolution of our structure

A burgeoning area in the field of ACE inhibitor design is the generation of domain specific inhibitors to more precisely regulate the actions -of the N- and C-domains of sACE. The structures of two new inhibitors have been published, RXP407 and RXP A380, which are highly specific for the N and C domains, respectively. The structural determinants of RXP470 are known to be the N-terminal aspartate and N- acetyl groups in the P₂ position and the C-terminal amide.

The. difference in phosphinic peptides at the^" P₂ position utilises the^~differences iir the N- and -C-demain active site at the S₂ subsite (Table 2). RXPA38O has a large hydrophobic phenyl group at this position, whereas the N-domain specific RXP407 Ms a charged aspartate residue and an N-terminus acetyl group. This corresponds to the exchange of a phenylalanine residue in the C-domain tθ^"Tyr 369 in the N domain. It is probable that the RXP A380 phenyl residue would form a stacking interaction with the Phe391 of tACE, whereas the aspartate or carbonyl (if the aspartate group forms electrostatic interactions with Arg500) of RXP407 would interact with the hydroxyl group of Tyr369 in the N-domain. Interestingly, in both the minimally glycosylated and lisinopril-bound N-domain structure, a patch of difference density was observed adjacent to Tyr369. This was modelled as a water molecule in the minimally glycosylated structure and a cluster of 2-3 water molecules in the lisinopril- bound structure as it was not possible to tell if it was a larger ligand, e.g. from the crystallisation solution,- at this resolution. It is possible that these water molecules in some way mimic the interactions the N-domain would have with extended inhibitors such as RXP407. Indeed, RXP407 can be modelled to make a similar interaction with Tyr369 (Fig 3(B)).

In our structure of the N-domain protein, the triad of residues (Gln259, Lys489, Tyr498), which interact with the carboxyl group of lisinopril, are best placed to interact with the C terminal amide. -However, this triad in conserved in the C-domain and the residues that differ between the N- and C-domains are all located further 0 down the cavity. These include Ser357 and Thr358 (both valine in the C-domain) and a patch of acidic residues (Fig 3b). Although the C-domain also has a patch of 2, rather than 3 acidic residues, they are either different in length or position (Table X). These residues adopt random conformations in our structure, which lack partner/s in the S₂ subsite for them to interact with, but could possibly extend towards the active 5 site and interact in the presence of RXP407. Although the resolution of our structure hinders a more detailed analysis of the active site, the structural details presented here will aid future rational design of domain-specific ACE inhibitors.

In a further aspect, the present invention relates- to- a composition comprising the N- ft- domain of ACE protein in a crystalline form.

rn a further aspe.et, the -present invention relates to a- scalable 3D model- of the N- domain of ACE protein having at least a portion of the structural co-ordinates set forth in Table A-or Table B. 5

All -publications mentioned in the above specification are herein incorporated ^"by reference. Various modifications and variations of the described methods and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in 0 connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in molecular biology or related fields are intended to be within the scope of the following claims. 73

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TABLE l. Crystallographic Data

RMSD, root-mean-square deviation.

Outer shell, 3.11-3.00 A and 2.95-2.8 A for the native data and lisinoprii complex respectively. i?free calculation used 4% and 2.3% of the reflections for the native data and lisinopril complex respectively.

TABLE 2.

Active site residues that differ between the N and C domains (C domain numbering is as for tACE).

Table A.

REMARK coordinates from restrained individual B-factor refinement

REMARK refinement resolution: 500.0 - 3 A REMARK starting

0.2748

REMARK final r= 0.2249

0.2737

REMARK B rmsd for bonded mainchain atoms= 1.061 target= 1.5

REMARKB rmsd for bonded sidechain atoms= 1.449 targets 2.0

REMARKB rmsd for angle mainchain atoms= 1.846 target= 2.0 REMARK B rmsd for angle sidechain atoms= 2.327 target= 2.5

REMARK rweight= 0.1000 (with wa= 4.39844)

REMARK target= mlf steps= 30

REMARK sg= C222(l) a= 101.12 b= 211.32 c= 171.27 alpha= 90 beta= 90 gamma=

90 REMARK parameter file 1 : CNS_TOPPAR:protein_fep.param

REMARK parameter file 2 : CNS_TOPPAR:ion.param

REMARK parameter file 3 : ../../../nlis/cns/both.par

REMARK parameter file 4 : CNS_TOPPAR:water_rep,param

REMARK parameter file 5 : ../carb.par REMARK molecular structure file: gen.mtf

REMARK input coordinates: rig.pdb

REMARK reflection file= ../sftools_rf.cv

REMARK ncs?= none

REMARK B-correction resolution: 6.0 - .3 REMARK B-factox correction applied to coordinate array B: -0.004

REMARK bulk solvent: density level- 0.337337 e/A^Λ3, B-factor= 25.5172 A^Λ2

REMARK reflections with |Fobs|/sigma_F < 0.0 rejected

REMARK reflections with |Fobs| > 10000 * rms(Fobs) rejected

REMARK theoretical total number of refl. in resol. range: 37102 ( LOO.O % ) REMARK number of unobserved reflections (no entry or |F|=0): 1459 ( 3.9 % )

REMARK number of reflections rejected: 0 ( 0.0 % )

REMARK total number of reflections used: 35643 ( 96.1 % )

REMARK number of reflections in working set: 34202 ( 92.2 % )

REMARK number of reflections in test set: 1441 ( 3.9 % ) CRYSTl 101.120211.320 171.27090.0090.0090.00 C 2221 REMARK FILENAME="rbind.pdb"

REMARK DATE:01-Sep-2005 10:51:14 created by user: hazel REMARK VERSION: 1.1

ATOM I CB ALAA 1 -23.864-35.275 -7.565 1.0059.70 A ATOM 2 C ALAA 1 -24.294-17.717 -7.1481.0060.38 A ATOM 3 O ALAA 1 -23.961-38.780 -6.6181.0059.62 A ATOM 4 N ALAA 1 -22.652-37.006 -8.8571.0060.75 A ATOM 5 CA ALAA 1 -23.242-36.679 -7.533 1.0060.39 A ATOM 6 N ASPA 2 -25.560-37.406 -7.4221.0060.30 A ATOM 7 CA ASPA 2 -26.661-38.306 -7.091 LOO 60.51 A ATOM- 8 CB ASPA 2 -27.942-37.862 -7.8091.0061.34 A ATOM 9 CG ASPA 2 -29.144-38.732 -7.4561.0062.14 A ATOM 10 ODlASPA 2 -29.480-38.824 -6.2561.0062.49 A ATOM 11 OD2ASPA 2 -29.752-39.323 -8.3771.0062.26 A ATOM 12 C ASPA 2 -26.318-39.742 -7.4761.0059.93 A ATOM 13 O ASPA 2 -25.833-40.000 -8.576 LOO 61.20 A ATOM 14 N PRO A 3 -26.562-40.699 -6.568 1.0058.59 A ATOM 15 CD PROA 3 -27.098 -40.534 -5.2061.0058.27 A ATOM 16 CA PRO A 3 -26.266-42.110 -6.842 1.0057.14 A ATOM 17 CB PRO A 3 -26.435-42.763 -5.473 1.0057.38 A ATOM 18. CG PROA 3 -27.521 -41.944 -4.8571.0057.46 A ATOM 19 C PROA 3 -27.165 -42.740 -7.9141.0055.49 A _A-TOM 20 O PROA 3 -26.738-43.633 -8.651 1.0054.12 A ATOM 21 N GLYA 4 -2-8.404 -42.266 -7.993 1.OJO 54T53 A

ATOM 22 GA GLYA 4 -29.33S-42.792 -8.9721.0053.M A

ATOM 23 C GLYA 4 -28.945-42.517-10.4-13 1.0O53.Z8 A

ATOM 24 O GLY A -4- -29.479-43.141-11.3271.0053.35 A

ATOM 25 N LEUA 5 -28.014 -41.586 -10.6171.0052.87 A

ATOM 26 CA LEUA 5 -27.549-41.228-11.9551.0051.15 A

ATOM 27 CB LEUA 5 -27.476-39.706-12.1081.0048.94 A

ATOM 28 CG LEUA 5 -28.805 -38.944 -12.0681.0047.11 A

ATOM 29 CDlLEUA 5 -28.548-37.466-11.943 1.0044.60 A

ATOM 30 CD2LEUA 5 -29.602-39.232-13.3171.0045.99 A _8y

ATOM 31 C LEUA 5 -26.188-41.837-12.2501.0051.49 A

ATOM 320 LEUA 5 -25.695-41.731-13.3671.0051.18 A

ATOM 33 N GLNA 6 -25.640-42.563-11.3271.0052.94 A

ATOM 34 CA GLNA 6 -24.384-43.191-11.5561.0055.39 A ATOM 35 CB GLNA 6 -23.816-43.588-10.2441.0055.97 A

ATOM 36 CG GLNA 6 -22.367-43.717-10.213 1.0058.03 A

ATOM 37 CD GLNA 6 -21.757-42.560 -9.541 1.0060.50 A

ATOM 38 OElGLNA 6 -20.540-42.472 -9.411 1.0061.49 A

ATOM 39 NE2GLNA 6 -22.588-41.634 -9.128 1.0061.55 A ATOM 40 C GLNA 6 -24.552-44.384-12.4081.0056.59 A

ATOM 41 O GLNA 6 -25.617-44.840-12.561 1.0057.06 A

ATOM 42 N PROA 7 -23.486-44.903-12.966 1.0057.69 A

ATOM 43 CD PROA 7 -22.106-44.441-12.730 1.0059.02 A

ATOM 44 CA PRO A 7 -23.568-45.839-14.090 1.0058.62 A ATOM 45 CB PROA 7 -22.112-46.258-14.295 1.0058.58 A

ATOM 46 CG PROA 7 -21.323-45.076-13.848 1.0058.80 A

ATOM 47 C PROA 7 -24.422-47.058-13.755 1.0059.55 A

ATOM 48 O PROA 7 -25.532-47.191-14.271 1.0061.74 A

ATOM 49 N GLYA 8 -23.904-47.933-12.9001.0058.50 A ATOM 50 CA GLYA 8 -24.431-49.279-12.775 1.0058.31 A

ATOM 51 C GLYA 8 -23.347-50.336-12.851 1.0058.41 A

ATOM 52 O GLYA 8 -22.330-50,246-12.1641.0060.78 A

ATOM 53 N ASNA 9 -23.566-51.343-13.691 1.0056.71 A

ATOM 54 CA ASN A 9 -22 J50 -52.354 -13.9571.0054.49 A ATOM 55 CB ASNA 9 -22 Λ 44 -53.058 -12.661 1.00=56.78 A

ATOM 56 CG ASNA 9 -20.641 -53^085 -12.4591.0059.68 A

ATOM 57 ODlASNA- 9 -19.884-53.385-13.383 1.0060.14 A

ATOM 58- -ND2 ASN A 9 -20.202 -52.770 -11.246- 1.0060.77 A

ATOM 59 C ASNA 9 -23-011-53.379-14.988 1.0052.08 A ATOM 600 ASNA 9 -24.188-53.735-15.0401.0051.49 A

ATOM 61 N PHEA 10 -22.075-53.848-15.808 1.0048.84 A

ATOM 62 CA PHEA 10 -22.390-54.279-17.163 1.0046.09 A

ATOM 63 CB PHEA 10 -22.552-53.069-18.0861.0040.73 A

ATOM 64 CG PHEA 10 -23.805-52.278-17.8371.0036.00 A _8g

ATOM 65 CDlPHEA 10 -23.749-51.046-17.2081.0034.11 A

ATOM 66 CD2PHEA 10 -25.039-52.766-18.233 1.0034.82 A

ATOM 67 CElPHEA 10 -24.899-50.314-16.978 1.0033.62 A

ATOM 68 CE2PHEA 10 -26.193-52.040-18.005 1.0033.24 A ATOM 69 CZ PHEA 10 -26.123 -50.813 -17.377 LOG 32.41 A

ATOM 70 C PHE A 10 -21.299 -55.200 -17.7001.0047.33 A

ATOM 71 O PHEA 10 -20.140-55.102-17.298 1.0047.54 A

ATOM 72 N SERA 11 -21.694-55.981-18.685 1.0049.09 A

ATOM 73 CA SERA 11 -20.944-57.050-19.260 1.0051.16 A ATOM 74 CB SERA 11 -2 L914 -57.969 -19.948 1.0052.18 A

ATOM 75 OG SERA 11 -23.230-57.711-19.528 1.0055.83 A

ATOM 76 C SERA 11 -20.010-56.527-20.270 1.0051.37 A

ATOM 770 SERA Il -20.347-55.675-20.9971.0051.24 A

ATOM 78 N ALAA 12 -18.805 -57.001 -20.3171. OD 52.26 A ATOM 79 CA ALAA 12 -17.885-56.442-21.2341.0053.18 A

ATOM 80 CB ALAA 12 -16.590-56.722-20.875 1.0051.57 A

ATOM 81 C ALAA 12 -18.135-56.963-22.5751.0054.43 A

ATOM 82 O ALAA 12 -17.211-57.231-23.3121.0054.12 A

ATOM 83 N ASPA 13 -19.420-57.091-22.875 1.0055.79 A ATOM 84 CA ASPA 13 -19.948-57.734-24.0601.0056.36 A

ATOM 85 CB ASPA 13 -21.115 -58.589-23.693^" 1.0059.30 A

ATOM 86 CG ASPA 13 -20.718-59.905-23.260 1.0062.75 A

ATOM- 87 ODlASPA 13 -1-9.530 -60.209 -23.368 LOO 63.30 A

ATOM 88 ΘD2ASPA 13 -21.523 -60.720 -22.798 U9065.19 A ATOM 89 C ASPA 13 -20.579 -56.691 -24.885 1.0055.46 A

ATOM 900 ASPA 13 -20.817 -55.62S -24.4381,0055.52 A

ATOM 91 N GLUA 14 -2Q.926 -57.029 -26.093 -1.0054.03 A

ATOM- 92 CA GLUA 14 -21.653-56.087-26.9341.0051.76 A

ATOM 93 CB GLUA 14 -21.555-56.497-28.4071.0052.19 A ATOM 94 CG GLUA 14 -22.396-55.627-29.3491.0051.31 A

ATOM 95 CD GLUA 14 -22.124-55.902-30.8141.0049.65 A

ATOM 96 OElGLUA 14 -22.807-55.278-31.6571.0047.71 A

ATOM 97 OE2GLUA 14 -21.228-56.730-31.1101.0048.97 A

ATOM 98 C GLUA 14 -23.114-56.059-26.4961.0050.39 A _rø

ATOM 99 O GLUA 14 -23.824-55.074-26.723 1.0048.36 A

ATOM 100 N ALAA 15 -23.557-57.152-25.875 1.0049.54 A

ATOM 101 CA ALAA 15 -24.931-57.249-25.3921.0048.17 A

ATOM 102 CB ALAA 15 -25.307-58.697-25.151 1.0048.26 A ATOM 10J C ALAA 15 -24.995-56.456-24.0991.0047.03 A

ATOM 104 O ALAA 15 -26.058-55.989-23.6941.0046.94 A

ATOM 105 N GLYA 16 -23.839-56.312-23.4581.0045.43 A

ATOM 106 CA GLYA 16 -23.769-55.537-22.240 1.0044.21 A

ATOM 107 C GLYA 16 -23.904-54.083-22.638 1.0044.56 A ATOM 108 O GLYA 16 -24.717-53.343-22.0871.0044.15 A

ATOM 109 N ALAA- 17 33.113 -53.686-23.6301.0044.88 A

ATOM 110 CA ALAA 17 -23.111-52.321-24.1441.0043.99 A

ATOM 111 CB ALAA 17 -22.103-52.205-25.2771.0042.98 A

ATOM 112 C ALAA 17 -24.490-51.863-24.613 1.0043.79 A ATOM 113 O ALAA 17 -24.898 -50.734 -24 J51 1.0043.30 A

ATOM 114 N GLNA 18 -25.206-52.729-25.319 1.0044.14 A

ATOM 115 CA GLNA 18 -26.542-52.377-25.7871.0044.90 A

ATOM 116 CB GLNA 18 -27.218-53.578-26.4521.0045.72 A

ATOM 117 CG GLNA 18 -27.143-53.613-27.9761.0047.20 A ATOM 118 CD GLNA 18 -27.934-52.490-28.6391.0047.56 A

ATOM 119 OEl GLNA 18 -28.877-51.943-28.0561.0046.17 A

ATOM 12ΘNE2GLNA 1-8 -27.563-52.156-29.8721.0047.95 A

ATOM 121 C GLNA 18 ,27.352-51.948-24.5741.0045.56 A

ATOM^" 1220 GLNA 18 -28.210 -5hθ67 -24,6581.0046.3Θ A ATOM^" 123 N LEUA 1-9- -27.073 -52.5S8 -23.4421.0045.38 A

ATOM 124 CA LEUA 1-9 -27.764-52.284-22.1-891.0044.17 A

ATOM- 125 CB LEUA 19 -27.632 -53.475 -^"21.2321.0042.95 A

ATOM 126 CG LEUA 19 -28.423-54.697-21.695 1.0041.27 A

ATOM 127 CDlLEUA 19 -28.083-55.910-20.851 1.0040.33 A ATOM 128 CD2 LEU A 19 -29.908-54.373-21.6161.0041.16 A

ATOM 129 C LEUA 19 -27.190-51.009-21.5621.0043.72 A

ATOM 130 O LEUA 19 -27.941-50.121-21.143 1.0043.82 A

ATOM 131 N PHEA 20 -25.859-50.935-21.5171.0042.38 A

ATOM 132 CA PHEA 20 -25.142-49.783-20.9801.0041.22 A _gQ

ATOM 133 CB PHEA 20 -23.656-49.891-21.3281.0041.22 A

ATOM 134 CG PHEA 20 -22.865-48.666-20.991 1.0042.77 A

ATOM 135 CDlPHEA 20 -22.194-48.565-19.778 1.0044.56 A

ATOM 136 CD2 PHE A 20 -22.816-47.592-21.8721.0043.78 A ATOM 137 CElPHEA 20 -21.480 -47.407-19.4371.0044.75 A

ATOM 138 CE2 PHE A 20 -22.109 -46.42S -21.547 T.0045.36 A

ATOM 139 CZ PHEA 20 -21.438-46.336-20.323 1.0045.39 A

ATOM 140 C PHEA 20 -25.712-48.507-21.593 1.0041.34 A

ATOM 141 O PHEA 20 -26.030-47.551-20.8841.0041.48 A ATOM 142 N ALA A 21 -25.839-48.506-22.918 1.0040.47 A

ATOM 143 CA ALAA 21 -26.358 -47.360 -23,6441.00^"39.24 A

ATOM 144 CB ALAA 21 -26.173 -47.572-25.126- 1.003&89 A

ATOM 145 C ALAA 21 -27.821-47.098-23.3371.0039.35 A

ATOM 146 O ALAA 21 -28.235-45.950-23.2071.0039.42 A ATOM 147 N ALAA 22 -28.603 -4S.164 -23.2261.0039.34 A

ATOM 148 CA ALAA 22 -30.025-48.031-22.943 1.0040.16 A

ATOM 149 CB ALAA 22 -30.678-49.416-22.8661.0039.74 A

ATOM 150 C ALAA 22 -30.212-47.280-21.631 1.0041.24 A

ATOM 151 O ALAA 22 -31.111-46.444-21.4991.0040.59 A ATOM 152 N SERA 23 -29.338-47.575-20.6701.0043.22 A

ATOM 153 CA SERA 23 -29375-46.962-19.3421.0045.22 A

ATOM 154 CB SERA 23 -28.454-47.745-18.3951.0045.73 A

ATOM 155 OG SERA 23 -28.820 -47J79 -1-7.0361.0046.34 A

ATOM 136 C SERA 23 -28.945--45.489 -19.405- 1.0045.96 A ATOM 157 O SERA 23 -29:725 -44.587-19.057 H)O 45.92 A

ATOM 158 N TYRA 24 -27.712-45.268-19.851 1.0045.86 A

ATOM 159 CA TYRA 24 -27. BO -4JL933 -20.005 1.0045.14 A

ATOM 160.CB TYRA 24 -25.937 -44.005^"-20.9601.0046τl3 A

ATOM 161 CG TYRA 24 -25.428 -42.656-21.418 LOO 48.06 A ATOM 162 CDlTYRA 24 -24.937-41.724-20.5021.0048.24 A

ATOM 163 CElTYRA 24 -24.447-40.487-20.9241.0048.03 A

ATOM 164 CD2 TYR A 24 -25.418-42.312-22.773 1.0048.40 A

ATOM 165 CE2 TYR A 24 -24.926-41.075-23.203 1.0047.52 A

ATOM 166 CZ TYRA 24 -24.441-40.171-22.272 1.0047.46 A ATOM 167 OH TYRA 24 -23.926-38.965-22.681 1.0046.28 A

ATOM 168 C TYRA 24 -28.135-42.932-20.556 1.0043.62 A

ATOM 1690 TYRA 24 -28.262-41.813-20.073 1.0043.13 A

ATOM 170 N ASNA 25 -28.929-43.346-21.5241.0042.36 A ATOM 171 CA ASNA 25 -29.938-42.520-22.209 1,00-41.72 A

ATOM 172 CB ASNA 25 -30.661-43.333-23.3171.0040.46 A

ATOM 173 CG ASNA 25 -31.894-42.671-23.871 1.0040.43 A

ATOM 174 ODlASNA 25 -31.786-41.746-24.5571.0040.06 A

ATOM 175 ND2 ASN A 25 -33.046-43.226-23.6621.0041.17 A ATOM 176 C ASNA 25 -30.945-42.002-21.2991.0042.17 A

ATOM 177 O ASNA 25 -31.347-40.879-21.3641.0041.04 A

ATOM 178 N ALA A 26 -3.1.448 -42.8S3 -20.485 IJOO 42.92 A

ATOM 179 CA ALAA 26 -32.520-42.491-19.5741.0043.29 A

ATOM 180 CB ALAA 26 -33.096-43.719-18.9061.0043.39 A ATOM 181 C ALAA 26 -32.033-41.505-18.5191.0043.47 A

ATOM 182 O ALAA 26 -32.735-40.546-18.1701.0042.67 A

ATOM 183 N SERA 27 -30.828-41.756-18.015 1.0042.93 A

ATOM 184 CA SERA 27 -30.213-40.914-17.000 1.0042.95 A

ATOM 185 CB SERA 27 -29.057-41.665-16.3491.0042.26 A ATOM 186 OG SERA 27 -29.430-42.996-16.056 1.0043.10 A

ATOM 187 C SERA 27 -29.696-39.602-17.601 1.0043.34 A

ATOM 188 O SERA 27 -29.921-38.519-17.054 1.0044.12 A

ATOM 189 N- ALAA 2$ -28.994-39.709-18_^725 1.0043.11- A

ATOM 190 CA ALAA 28 -28.439-38.551 -19.406- LOO 41.8Ϊ A ATOM 191 eB ALAA 28 -27.744-38:990-20.6841. GO 4t:60- A

ATOM 192 C ALAA 28 -29.509 -37.522-19.716 1.0041.28 A

ATOM 193^" O ALA A 28 -29.259 -3€.333 -19:638 1.00-40:80 A-

ATOM 194 N GLUA 29 -30.705-37.973-20.065 1.0042.45 A

ATOM 195 CA GLUA 29 -31.787-37.047-20.383 1.0044.68 A ATOM 196 CB GLUA 29 -33.071-37.805-20.7161.0046.96 A

ATOM 197 CG GLUA 29 -33.234-38.182-22.169 1.0050.48 A

ATOM 198 CD GLUA 29 -34.695-38.358-22.535 1.005339 A

ATOM 199 OEl GLUA 29 -34.996-38.538-23.7321.0055.17 A

ATOM 200 OE2 GLU A 29 -35.546-38.313-21.618 1.0054.90 A ^

ATOM 201 C GLUA 29 -32.074-36.099-19.235 1.0044.97 A

ATOM 202 O GLUA 29 -32.508-34.967-19.438 1.0043.63 A

ATOM 203 N GLNA 30 -31.835-36.582-18.022 1.0047.08 A

ATOM 204 CA GLNA 30 -32.075-35.800-16.8141.0047.50 A ATOM 205 CB GLNA 30 -32.197-36.734-15.603 1.0048.02 A

ATOM 206 CG GLNA 30 -33.439-37.630-15.659 1.0050.84 A

ATOM 207 CD GLNA 30 -33.578-38.549-14.453 1.0052.87 A

ATOM 208 OEl GLNA 30 -33.549-38.090-13.3061.0053.65 A

ATOM 209 NE2 GLN A 30 -33.738-39.854-14.7041.0052.00 A ATOM 210 C GLNA 30 -30.961-34.789-16.605 1.0046.87 A

ATOM 2110 GLNA 30 -31.215-33.586-16.5401.0046.42 A

ATOM 212 N VALA 31 -29.767-35.290-16.426 1.0045.83 A

ATOM 213 CA VALA 31 -28.581-34.501-16.4381.0045.79 A

ATOM 214 CB VALA 31 -27.435-35.328-16.3801.0044.91 A ATOM 215 CGlVALA 31 -26.531-34.815-17.2171.0045.05 A

ATOM 216 CG2 VAL A 31 -26.928-35.265-15.128 1.0044.72 A

ATOM 217 C VALA 31 -28.393-33.447-17.506 1.0045.62 A

ATOM 218 O VALA 31 -27.843-32.406-17.291 1.0045.78 A

ATOM 219 N LEUA 32 -28.879-33.719-18.668 1.0044.73 A ATOM 220 CA LEUA 32 -28.826-32.778-19.770 1.0044.36 A

ATOM 221 CB LEUA 32 -28.927-33.505-21.1161.0042.88 A

ATOM 222 CG LEUA 32 -27.618-34.185-21.522 1.0040.77 A

ATOM 223 CDlLEUA 32 -27JL89 -34.967 -22.795 1.004L40 A

ATOM 224 CD2LEUA 32 -26:552 -33.126_^21.693 1.0041.02 A ATOM _225 -C LEU A- 32 -29.932 -31J52- 19.628 1.0044.37 A

ATOM 22« O LEUA 32 -29.697-30.559-19.803 1.0044.83 A

ATOM 227 N PHE A 33 -31.136 -3Z206 -».3001.0044.42 A

ATOM 228 CA PHEA 33 -32.247-31.274-19.129 1.0045.58 A

ATOM 229 CB PHEA 33 -33.503-31.977-18.615 1.0041.98 A ATOM 230 CG PHEA 33 -34.632-31.034-18.3141.0037.18 A

ATOM 231 CDlPHEA 33 -35.524-30.658-19.304 1.0036.69 A

ATOM 232 CD2 PHE A 33 -34.776-30.491-17.049 1.0034.63 A

ATOM 233 CElPHEA 33 -36.547-29.752-19.032 1.0035.20 A

ATOM 234 CE2 PHE A 33 -35.792-29.586-16.771 1.0033.33 A ^

ATOM 235 CZ PHEA 33 -36.677-29.216-17.761 1.0033.23 A

ATOM 236 C PHEA 33 -31.884-30.182-18.1291.0048.29 A

ATOM 237 O PHEA 33 -32.073-28.994-18.3991.0049.21 A

ATOM 238 N GLNA 34 -31.366-30.590-16.972 1.0050.83 A ATOM 239 CA GLNA 34 -31.003-29.637-15.933 1.0052.45 A

ATOM 240 CB GLNA 34 -30.497-30.372-14.6841.0053.44 A

ATOM 241 CG GLNA 34 -29.232-31.184-14.853 1.0056.33 A

ATOM 242 CD GLNA 34 -28.044-30.587-14.095 1.0059.76 A

ATOM 243 OEl GLNA 34 -28.219-29.928-13.058 1.0060.10 A ATOM 244 NE2 GLN A 34 -26.827-30.832-14.600 1.0061.3S A

ATOM 245 C GLNA 34 -29.987-28.598-16.3971.0052.59 A

ATOM 246 O GLNA 34 -30.253-27.396-16.2981.0053.04 A

ATOM 247 N SERA 35 -28.876-29.058-16.928 1.0051.15 A

ATOM 248 CA SERA 35 -27.868-28.192-17.423 1.0049.99 A ATOM 249 CB SERA 35 -26.757-28.984-17.9601.0049.90 A

ATOM 250 OG SERA 35 -26.782-28.826-19.334 1.0053.34 A

ATOM 251 C SERA 35 -28.293-27.267-18.482 1.0048.72 A

ATOM 2520 SERA 35 -27.766-26.195-18.545 1.0048.49 A

ATOM 253 N VALA 36 -29.193-27.697-19.3481.0046.52 A ATOM 254 CA VALA 36 -29.766-26.919-20.4401.0044.76 A

ATOM 255 CB VALA 36 -30.485 -27.832 -^"21.4621.0044.34 A

ATOM 256 CGlVALA 36 -31.303-26.995-22.4371.0041.86 A

ATOM 257 CG2 VAL A 36 -29.460 -28.670 -22.2121.0043.46 A-

ATOM 258- C VALA 36 -30.762 -25.S88 -19.9251.0044.06- A ATOM 259 O VALA 36 -30:761 -24.740 -20.372 tflfl 43.33 A

ATOM 260 N ALAA 37 -31.61Θ -26.302-18.9861.0043.05 A

ATOM- 261 CA ALAA 37 -32.617-25.409-18.4201.0042.33 A

ATOM 262 CB ALAA 37 -33.578-26.191-17.5601.0041.35 A

ATOM 263 C ALAA 37 -31.948-24.312-17.6021.0041.62 A ATOM 264 O ALAA 37 -32.443-23.187-17.5241.0039.76 A

ATOM 265 N ALAA 38 -30.811-24.658-17.003 1.0041.33 A

ATOM 266 CA ALAA 38 -30.037-23.727-16.1901.0041.12 A

ATOM 267 CB ALAA 38 -28.853-24.454-15.5401.0040.21 A

ATOM 268 C ALAA 38 -29.532-22.600-17.081 1.0041.12 A ATOM 269 O ALAA 38 -29.656-21.416-16.758 1.0041.30 A

ATOM 270 N SERA 39 -28.946-22.985-18.205 1.0040.59 A

ATOM 271 CA SERA 39 -28.434-22.022-19.148 1.0038.72 A

ATOM 272 CB SERA 39 -27.790-22.745-20.3201.0036.81 A ATOM 273 OG SERA 39 -26.773-23.617-19.8641.0035.22 A

ATOM 274 C SERA 39 -29.594-21.169-19.631 1.0039.25 A

ATOM 275 O SERA 39 -29.499-19.944-19.6471.0039.58 A

ATOM 276 N TRPA 40 -30.700-21.809-20.005 1.0039.54 A

ATOM 277 CA TRPA 40 -31.856-21.064-20.4981.0039.85 A ATOM 278 CB TRPA 40 -33.053-21.989-20.756 1.0038.38 A

ATOM 279 CG TRPA 40 -34.290-21.23.5-21.2041.0037.06 A

ATOM 280 CD2 TRP A- 40 -34.594 -20.783 -22J321.0037.49 A

ATOM 281 CE2 TRP A 40 -35.814-20.076-22.4641.0036.99 A

ATOM 282 CE3 TRP A 40 -33.955 -2fl.9O6 -23.771 1.0037.44 A ATOM 283 CDlTRPA 40 -35.311-20.794-20.415 1.0037.37 A

ATOM 284 NEl TRPA 40 -36.230-20.098-21.161 1.0036.56 A

ATOM 285 CZ2 TRP A 40 -36.406-19.495-23.583 1.0036.70 A

ATOM 286 CZ3 TRP A 40 -34.547-20.328-24.8821.0037.03 A

ATOM 287 CH2 TRP A 40 -35.761-19.632-24.7781.0037.26 A ATOM 288 C TRPA 40 -32.278-19.940-19.5681.0040.95 A

ATOM 289 O TRPA 40 -32.894-18.976-20.0171.0041.96 A

ATOM 290 N ALAA 41 -31.955 -20:059 -18.2&1 1.0042.31 A

ATOM 291 CA ALAA 41 -32.305-19.022-17.3041.0042.16 A

ATOM 292 CB ALA A -41 -32.400-19:623-15.9061.0040.87 A ATOM 293 C ALAA 41 -31.259-17.909-17.331 1.0042.14 A

ATOM 294 θ ALAA 41 -31.583-16.734-17.170-1.0042.22 A

ATOM 295 N HIS A 42 -30.006 -18.296 -17:552 1.0042.74 A

ATOM 296 CA HIS A 42 -28.895-17.359-17.610 1.0044.17 A

ATOM 297 CB HISA 42 -27.576-18.132-17.5101.0047.34 A ATOM 298 CG HIS A 42 -26.350-17.288-17.699 1.0050.69 A

ATOM 299 CD2 HIS A 42 -25.534-16.686-16.801 1.0051.45 A

ATOM 300 NDlHISA 42 -25.828-16.997-18.943 1.0052.32 A

ATOM 301 CElHISA 42 -24.744-16.255-18.801 1.0052.42 A

ATOM 302 NE2 HIS A 42 -24.543-16.052-17.511 1.0052.35 A ATOM 303 C HIS A 42 -28.904 -16.500 -18.8741.0044.50 A

ATOM 304 O HISA 42 -28.657-15.297-18.8161.0045.04 A

ATOM 305 N ASPA 43 -29.190-17.127-20.010 1.0044.95 A

ATOM 306 CA ASPA 43 -29,220-16.424-21.2871.0044.34 A ATOM 307^" CB ASPA 43 -29.186-17.420-22.4481.0046.25 A

ATOM 308^"CG ASPA 43 -27.848-18.121-22.575 1.0048.09 A

ATOM 309 ODlASPA 43 -27.624-18.794-23.603 1.0050.16 A

ATOM 310 OD2 ASP A 43 -26.961-18.057-21.6991.0047.76 A

ATOM^" 311 C ASPA 43 -30.453-15.533-21.3971.0043.59 A ATOM 312 O ASPA 43 -30.359-14.375-21.805 1.0043.18 A

ATOM 313 N THRA 44 -31.608-16.083-21.0371.0043.46 A

ATOM 314 CA THRA 44 -32.847-15.315-21.0141.0043.63 A

ATOM 315 CB THRA 44 -34.065-16.258-20.972 1.0043.18 A

ATOM 316 OGl THRA 44 -34.084-16.963-19.7241.0044.45 A ATOM 317 CG2 THR A 44 -33.914-17.369-22.000 1.0042.99 A

ATOM 318 C THRA 44 -32.876-14.368-19.821 1.0043.83 A

ATOM 319 O THRA 44 -33.845-13.637-19.6181.0042.40 A

ATOM 320 N ASNA 45 -3 L805 -14.387-19.0341.0045.28 A

ATOM 321 CA ASNA 45 -31.644-13.445-17.9341.0045.80 A ATOM 322 CB ASNA 45 -32.710-13.684-16.8641.0046,99 A

ATOM 323 CG ASNA 45 -32.704-12.617-15.7871.0047.94 A

ATOM 324 ODlASNA 45 -32.045-11.586-15.922 1.0050.43 A

ATOM 325 ND2 ASN- A 45 -33.441-12.860-14.709 1.0047.52 A

ATOM 326 C ASNA 45 -30.214-13.564-17.4171.0045.21 A - ATOM 327- O ASNA 45 -29.796-14.627-16.9591.0O47.02 A.

ATOM 328 N BLE A 46 -29.469 -T2.466 -17.4961.0042.84 A

.ATOM 329 CA ILEA 46 -2K080 -12.457 -17.051 1.0040.74 A

ATOM 330 CB ILEA 46 -27.199-11.682-18.0481.0040.63 A

ATOM 331- CG2 ILE A 46 -25.731-12.016-17.8321.0038.48 A ATOM 332 CGl DLE A 46 -27.619-11.995-19.4861.0040.60 A

ATOM 333 CDlILEA 46 -26.617-11.546-20.5261.0041.08 A

ATOM 334 C ILEA 46 -27.951-11.852-15.6571.0039.88 A

ATOM 335 O ILEA 46 -27.851-10.634-15.5061.0040.28 A

ATOM 336 N THRA 47 -27.956-12.709-14.6421.0039.44 A _%

ATOM 337 CA THRA 47 -27.669-12.283-13.278 1.0038.92 A

ATOM 338 CB THRA 47 -28.941-12.349-12.413 1.0039.07 A

ATOM 339 OGl THRA 47 -29.273-13.718-12.1501.0038.85 A

ATOM 340 CG2 THR A 47 -30.143 -il.84O -13.1921.0039.31 A ATOM 34-1 C THRA 47 -26.566-13.131-12.654 1.0038.66 A

ATOM 342 O THRA 47 -26.272 -l^'4.230 -13.1241.0038.32 A

ATOM 343 N ALAA 48 -25.958-12.613-11.592 1.0038.05 A

ATOM 344 CA ALAA 48 -24.918-13.336-10.875 1.0038.04 A

ATOM 345 CB ALAA 48 -24.364-12.473 -9.764 1.0037.51 A ATOM 346 C ALAJV 48 -25.461-14.651-10.3121.0038.98 A

ATOM 347 O ALA A 48 -24.764-15.670-10.3061.0037.62 A

ATOM 348- N- GLUA 49 -26.709-14.620 -9.8471.0040.23 A

ATOM 349 CA GLUA 49 -27.357-15.805 -9.290 1.0041.74 A

ATOM 350 CB GLUA 49 -28.744-15.457 -8.743 1.0043.66 A ATOM 351 CG GLUA 49 -29.516-16.653 -8.1791.0046.92 A

ATOM 352 CD GLUA 49 -28.783-17.357 -7.036 1.0049.42 A

ATOM 353 OEl GLUA 49 -28.329-16.665 -6.0971.0051.14 A

ATOM 354 OE2 GLU A 49 -28.669-18.604 -7.0621.0049.82 A

ATOM 355 C GLUA 49 -27.497-16.912-10.3321.0041.77 A ATOM 356 O GLUA 49 -27.112-18.055-10.071 1.0042.26 A

ATOM 357 N ASNA 50 -28.043-16.575-11.505 1.0040,90 A

ATOM 358 CA ASNA 50 -2O34-17.540 -12.593 LOO 39.66 A

ATOM 359 CB- ASN A- .50 -29.016-16.893-13.7441.0040.03 A

ATOM 36Θ= CG ASN A 50 -30.395 -16.405 -13.325 JLOO-40.57 A ATOM 361 OD-rASNA 50 -31.167 -17.137 -12J161.0039.95 A

ATOM 362 ND2 ASN A 50 -30.713 -15.169-13:67-0 1-.G041.49 A

ATOM 363 C ASNA_50 -26.904 -18.102 -13.1181:0039.05 A

ATOM 364 O ASNA 50 -26.799-19.285.-13.453 1.0038.23 A

ATOM 365 N ALAA 51 -25.891-17.246-13.185 1.0038.53 A ATOM 366 CA ALAA 51 -24.579-17.652-13.653 1.0038.51 A

ATOM 367 CB ALAA 51 -23.676-16.454-13.731 1.0039.07 A

ATOM 368 C ALAA 51 -24.006-18.663-12.6941.0038.93 A

ATOM 3690 ALAA 51 -23.490-19.694-13.101 1.0037.64 A

ATOM 370 N ARGA 52 -23.969-18.359-11.443 1.0041.76 A _gj

ATOM 371 CA ARGA 52 -23.634-19.321-10.415 1.0044.00 A

ATOM 372 CB ARGA 52 -24.103-18.752 -9.1181.0045.30 A

ATOM 373 CG ARGA 52 -23.052-18.588 -8.061 1.0047.98 A

ATOM 374 CD ARGA 52 -23.670-18.595 -6.7091.0050.52 A ATOM 375 NE ARGA 52 -24.739 -19.556- -6.775 1.0052.84 A

ATOM 376 CZ ARGA 52 -25.529-19.877 -5.8201.0053.09 A

ATOM 377 NHlARGA 52 -25.406-19.327 -4.653 1.0054.58 A

ATOM 378 NH2 ARG A 52 -26.441-20.773 -6.0371.0052.84 A

ATOM 379 C ARGA 52 -24.319-20.601-10.5571.0044^0 A ATOM 380 O ARGA 52 -23.738-21.633-10.513 1.0043.62 A

ATOM 381 N ARGA 53 -25.601-20.519-10.6801.0044.03 A

ATOM 382 CA ARGA 53 -26.411 -21.719 -10.855 1.0044.62 A

ATOM 383 CB ARGA 53 -27.860-21.345-11.1301.0045.23 A

ATOM 384 CG ARGA 53 -28.606 -20.787 -9.94810046.11 A ATOM 385 CD ARGA 53 -29.942-20.238-10.3991.0047.87 A

ATOM 386 NE ARGA 53 -30.649-19.622 -9.288 1.0048.96 A

ATOM 387 CZ ARGA 53 -31.289-20.302 -8.3461.0049.51 A

ATOM 388 NHlARGA 53 -31.317-21.629 -8.3871.0048.90 A

ATOM 389 NH2 ARG A 53 -31.891 -19.648 -7J581.0050.12 A ATOM 390 C ARGA 53 -25.895-22.535-12.0261.0044.63 A

ATOM 391 O ARGA 53 -25.558-23L712 -11.8741.0045.30 A

ATOM 392 N GLNA 54 -25.869-21.901-13.1971.0043.53 A

ATOM 393 CA GLN A 54 -25.387-22.534-14.4161.0042.03 A

ATOM 394 CB GDSTA 54 -25.198-21.462-15:4971.0042.88 A ATOM 395 CG GLNA -54 -23.S49-21.610-16.371 1.0043.26 A

ATOM 396 CD GLNA 54 -24.194-22.444-17.6091.0043.52 A

ATOM 397 OElGLNA 54 -25.045 -22.099^"-18.4.401.0045.48 A

ATOM 398 NE2 GLN A 54 -23.450-23.542-17.7471.0041.34 A

ATOM 399 C GLNA 54 -24.066-23.226-14.1181.0041.21 A ATOM 400 O GLNA 54 -23.930-24.432-14.2961.0040.40 A

ATOM 401 N GLUA 55 -23.100-22.452-13.6441.0040.67 A

ATOM 402 CA GLUA 55 -21.785-22.985-13.3381.0040.13 A

ATOM 403 CB GLUA 55 -20.938-21.918-12.6461.0040.90 A

ATOM 404 CG GLUA 55 -20.719-20.676-13.4961.0041.83 A _9g

ATOM 405 CD GLUA 55 -19.552-19.827-13.015 1.0044.05 A

ATOM 406 OEl GLUA 55 -18.456-20.385-12.7871.0044.78 A

ATOM 407 OE2 GLU A 55 -19.719-18.598-12.873 1.0045.51 A

ATOM 408 C GLUA 55 -21.876-24.232-12.4771.0039.53 A ATOM 409 O GLUA 55 -20.993-25.088-12.511 1.0039.05 A

ATOM 410 N ALAA 56 -22.953-24.337-11.708 1.0039.28 A

ATOM 411 CA ALAA 56 -23.158-25.496-10.845 1.0038.19 A

ATOM 412 CB ALAA 56 -24.161-25.159 -9.7491.0037.41 A

ATOM 413 C ALAA 56 -23.658-26.671-11.6821.0036.65 A ATOM 414 O ALAA 56 -23.057-27.748-11.691 1.0035.00 A

ATOM 415 N ALAA 57 -24.756-26.441-12.393 1.0035.68 A

ATOM 416 CA ALAA 57 -25.364 -27.446 -13.257 IJ)O 35.13 A

ATOM 417 CB ALAA 57 -26.478-26.805-14.0641.0035.01 A

ATOM 418 C ALAA 57 -24.332-28.082-14.193 1.0035.36 A ATOM 419 O ALAA 57 -24.415-29.272-14.5141.0034.72 A

ATOM 420 N ALAA 5S -23.370-27.272-14.631 1.0035.10 A

ATOM 421 CA ALAA 58 -22.299-27.717-15.5171.0034.51 A

ATOM 422 CB ALAA 58 -21.453-26.525-15.9271.0033.24 A

ATOM 423 C ALAA 58 -21.433-28.747-14.7941.0035.27 A ATOM 4240 ALAA 58 -21.034-29.763-15.3661.0035.05 A

ATOM 425 N LEUA 59 -21.155-28.467-13,5241.0035.58 A.

ATOM 426 CA LEUA 59 -20.342-29.337-12.6831.0034.70 A

ATOM 427 CB LEUA 59 -20.160-28.694-11.3141.0033.09 A

ATOM 428 CG LEU A 59 -L8.727 -28r279 -11.031 1.0031.07 A ATOM- 429 CDl L-EU A 59^" 48.688 -27.478- -9.7561.0028.84 A

ATOM 430 CD2 LEU A 59 -17:849-29.523-10.9581.0029:60 A

ATOM 431 C LEU A .59 -20.954-30.724-12.531 1.0034:78 A

ATOM 432 O LEUA 59 -20.235-31.723-12.423 1.0034.04 A

ATOM 433 N LEUA 60 -22.282-30.778-12.5101.0034.41 A ATOM 434 CA LEUA 60 -22.969-32.053-12.408 1.0035.26 A

ATOM 435 CB LEUA 60 -24.475-31.859-12.1871.0037.35 A

ATOM 436 CG LEUA 60 -24.900-31.464-10.7661.0039.66 A

ATOM 437 CDlLEUA 60 -26.401-31.236-10.7271.0039.89 A

ATOM 438 CD2 LEU A 60 -24.482-32.551 -9.7721.0039.75 A _nn

99

ATOM 439 C LEUA 60 -22.732-32.800-13.708 1.0034.24 A

ATOM 440 O LEUA 60 -22.224-33.920-13.7071.0033.75 A

ATOM 441 N SERA 61 -23.093-32.170-14.8201.0032.82 A

ATOM 442 CA SERA 61 -22.909-32.780-16.128 1.0030.82 A ATOM 443 CB SERA 61 -23.237-31.771-17.221 1.0030.79 A

ATOM 444 OG SERA 61 -24.610-31.414-17.1681.0033.24 A

ATOM 445 C SERA 61 -21.484-33.276-16.2671.0028.63 A

ATOM 446 O SERA 61 -21.248-34.423-16.6141.0027.43 A

ATOM 447 N GLNA 62 -20.523-32.416-15.985 1.0028.28 A ATOM 448 CA GLNA 62 -19.138-32.834-16.079 1.0030.22 A

ATOM 449 CB GLNA 62 -18.216-31.693-15.6401.0029.71 A

ATOM 450 CG GLNA 62 -18.228-30.511-16.590 1.0028.80 A

ATOM 451 CD GLNA 62 -17.735-29.236-15.9461.0031.00 A

ATOM 452 OEl GLNA 62 -18.280-28.794-14.935 1.0032.00 A ATOM 453 NE2 GLN A 62 -16.705-28.631-16.5281.0031.71 A

ATOM 454 C GLNA 62 -18.958-34.063-15.191 1.0031.66 A

ATOM 455 O GLNA 62 -18.220 -34.985 -15.5301.0031.56 A

ATOM 456 N GLUA 63 -19.655-34.064-14.0571.0033.93 A

ATOM 457 CA GLUA 63 -19.617-35.176-13.1041.0035.67 A ATOM 458 CB GLUA 63 -20.452-34.816-11.8771.0037.75 A

ATOM 459 CG GLUA 63 -19.712-34.849-10.5591.0043.26 A

ATOM 460 CD GLUA 63 -20.454-34.079 -9.4781.0046.89 A

ATOM 461 OElGLUA 63 -21.647-34.377 -9.253 1.0047.77 A

ATOM 462 OE2 GLU A 63 -19.-846 -33.174 -8.8601.0045.33 A ATOM 463 C GLUA 63- -20:195 -36.429 -lθ.778 h0035.57 A

ATOM 464 O GLUA 63 -19-.549 -37.480 -13.840 1:0.0-35.34- A

ATOM 465 N PHE A 64 -21.418 -36.289-14.285 1.0ΪT35.16- A

ATOM 466 CA PHEA 64 -22.135-37.349-14.9851.0035.53 A

ATOM 467 CB PHEA 64 -23.429-36.774-15.5601.00 J5.15 A ATOM 468 CG PHEA 64 -24.342-37.800-16.153 L(X) 36.52 A

ATOM 469 CDlPHEA 64 -25.563-38.084-15.5561.0037.98 A

ATOM 470 CD2 PHE A 64 -24.001-38.475-17.3141.0037.90 A

ATOM 471 CElPHEA 64 -26.437-39.029-16.1121.0039.80 A

ATOM 472 CE2PHEA 64 -24.867-39.419-17.875 1.0039.47 A _m

ATOM 473 CZ PHEA 64 -26.085-39.695-17.2721.0039.94 A

ATOM 474 C PHEA 64 -21.286-37.906-16.125 1.0036.53 A

ATOM 475 O PHEA 64 -21.051-39.110-16.2261.0035.88 A

ATOM 476 N ALAA 65 -20.838-36.999-16.985 1.0037.75 A ATOM 477 CA ALA A 65 -20.032-37.330-18.1471.0038.12 A

ATOM 478 CB ALAA 65 -19.673 -36.058 -18.887 1.003«.O7 A

ATOM 479 C ALAA 65 -18.769-38.088-17.793 1.0038.81 A

ATOM 480 O ALAA 65 -18.317-38.955-18.539 1.0038.19 A

ATOM 481 N GLUA 66 -18.223-37.876-16.643 1.004O.33 A ATOM 482 CA GLUA 66 -17.034-38.578-16.3651.0042.55 A

ATOM 483 CB GLUA 66 -16.340-38.029-15.2261.0044.34 A

ATOM 484 CG GLUA 66 -15.550 -39.157 -14.711 1.0048.57 A

ATOM 485 CD GLUA 66 -14.563-38.725-13.741 1.0051.41 A

ATOM 486 OEl GLUA 66 -14.973-38.086-12.771 1.0053.26 A ATOM 487 OE2 GLU A 66 -13.393-39.019-13.9771.0053.13 A

ATOM 488 C GLUA 66 -17.340-39.915-15.921 1.0042.56 A

ATOM 489 O GLUA 66 -16.620-40.820-16.190 1.0042.91 A

ATOM 490 N ALAA 67 -18.383-40.046-15.1521.0041.53 A

ATOM 491 CA ALAA 67 -18.726-4O75-14.651 1.0041.26 A ATOM 492 CB ALAA 67 -19.953-41.297-13.773 1.0040.81 A

ATOM 493 C ALAA 67 -18.950-42.396-15.759 1.0041.67 A

ATOM 494 O ALA A.67 -18.253-43.412-15.8271.0041.02 A

ATOM 495 N TRPA 68 -19.933 -42.137 -16.6151.0042.00 A

ATOM 496 CA TRPA--6S -20.219-43.050-17.7071.0042.69 A ATOM 497 CB TPJPA 68 -21.500 -42.655 -1&428- 1.0043.26 A

ATOM 498 CG TRgA 68 -22.6% -42.663 -17.5571.0044,43 A

ATOM 499 CD2T-RPA 68 -23.699-43.686-17.485 1.0044.08 A

ATOM 500 CE2 TRP A 68 -24.651-43.270-16,5271.0044.43 A

ATOM 501 CE3 TRP A 68 -23.887-44.914-18.138 1.0042.52 A ATOM 502 CDlTRPA 68 -23.064-41.700-16.6671.0045.09 A

ATOM 503 NEl TRPA 68 -24.239-42.056-16.0441.0044.76 A

ATOM 504 CZ2 TRP A 68 -25.780-44.043-16.2061.0044.22 A

ATOM 505 CZ3 TRP A 68 -25.010-45.679-17.8161.0041.97 A

ATOM 506 CH2TRPA 68 -25.939-45.238-16.860 1.0042.62 A _m

ATOM 507 C TRPA 68 -19.069-43.012-18.6841-0043.00 A

ATOM 508 O TRPA 68 -18.815-43.979-19.3951.0043.88 A

ATOM 509 N GLYA 69 -18.375-41.882-18.718 1.0042.52 A

ATOM 510 CA GLYA 69 -17.258-41.754-19.623 1.0042.00 A ATOM 511 C GLYA 69 -16.209-42.806-193391.0042.08 A

ATOM 512 O GLYA 69 -15.985-43.709-20.1471.0040.81 A

ATOM 513 N ALAA 70 -15.596-42.719-18.1721.0042.69 A

ATOM 514 CA ALAA 70 -14.524-43.631-17.7891.0042.80 A

ATOM 515 CB ALAA 70 -13.849-43.150-16.5141.0041.47 A ATOM 516 C ALAA 70 -15.047-45.052-17.6121.0042.51 A

ATOM 517 O ALAA 70 -14.230 -45.992 -17.585 LOO 4L80 A

ATOM 518 N LYSA 71 -16.333-45.213-17.4701.0043.36 A

ATOM 519 CA LYSA 71 -16.913-46.542-17.3201.0044.93 A

ATOM 520 CB LYSA 71 -18.306-46.461-16.6911.0044.65 A ATOM 521 CG LYSA 71 -19.104-47.771-16.7481.0044.40 A

ATOM 522 CD LYSA 71 -18.435-48.919-15.9901.0045.18 A

ATOM 523 CE LYSA 71 -18.565-48.788-14.4741.0044.52 A

ATOM 524 NZ LYSA 71 -17.937-49.942-13.7591.0042.88 A

ATOM 525 C LYSA 71 -17.008-47.162-18.706 1.0046.60 A ATOM 526 O LYSA 71 -16.451-48.234-18.953 1.0048.14 A

ATOM 527 N ALAA 72 -17.703-46.-468-19.6071.0047.30 A

ATOM 528 CA ALAA 72 -17.875 -46.921 -20.983^' 1. OO 46.59 A

ATOM- 529 CB ALAA 72 -18.421-45.792-21.8291.0045.99 A

ATOM 5313 C ALAA 72 -16.545 -47.406 -21.549.1.00-47.34 A " ATOM 531 O ALAA 72 -16.506-48.326-22.364.1.0.045.93 A

ATOM 532 N LYSA 73 -15.454 -46.787-21-. Ill 1.0048.Θ9 A

ATOM 533 CA LYSA 73 -14.137-47.187-2-1.576.1,0049.46 A

ATOM 534 CB LYSA 73 -13.289-45.950-21.9271.0050.52 A

ATOM 535 CG LYSA 73 -13.115 -44.913 -20.832 LOO 50.70 A ATOM 536 CD LYSA 73 -12.898-43.507-21.418 1.0050.52 A

ATOM 537 CE LYSA 73 -11.442-43.215-21.738 1.0049.77 A

ATOM 538 NZ LYSA 73 -11.271-41.787-22.118 1.0050.08 A

ATOM 539 C LYSA 73 -13.413-48.084-20.5761.0050.62 A

ATOM 540 O LYSA 73 -12.423-48.731-20.9271.0051.65 A _1Q2

ATOM 541 N ALAA 74 -13.907-48.120-19.343 1.0051.63 A

ATOM 542 CA ALAA 74 -13.513-49.149-18.388 1.0052.89 A

ATOM 543 CB ALAA 74 -14.553-49.277-17.2871.0052.93 A

ATOM 544 C ALAA 74 -13.296-50.491-19.078 1.0053.75 A ATOM 545 O ALAA 74 -12.309-51.181-18.8171.0054.95 A

ATOM 546 N LEUA 75 -14.222-50.857-19.9581.0054.15 A

ATOM 547 CA LEUA 75 -14.418-52.253-20.3261.0054.82 A

ATOM 548 CB LEUA 75 -15.417-52.923-19.381 1.0054.44 A

ATOM 549- CGXEU A 75 -16.848-52.385-19.4141.0052.75 A ATOM 550 CDlLEUA 75 -17.819 -53.405 -18.840 LOO 52.44 A

ATOM 551 CD2LEUAT5 -16τ944 -51.066-18.662 1.0050.85 A

ATOM 552 C LEUA 75 -14.891-52.387-21.7701.0055.25 A

ATOM 553 O LEUA 75 -15.002-53.494-22.2971.0055.96 A

ATOM 554 N TYRA 76 -15.153-51.254-22.413 1.0055.39 A ATOM 555 CA TYRA 76 -15.791-51.251-23.725 1.0055.20 A

ATOM 556 CB TYRA 76 -17.093-50.448-23.6861.0052.59 A

ATOM 557 CG TYRA 76 -18.267-51.215-23.122 1.0049.91 A

ATOM 558 CDlTYRA 76 -19.457-50.571-22.8121.0049.81 A

ATOM 559 CElTYRA 76 -20.533-51.268-22.2961.0049.70 A ATOM 560 CD2 TYR A 76 -18.185 -52L583 -22.8991.0048.38 A

ATOM 561 CE2 TYR A 76 -19.256-53.288-22.383 1.0049.58 A

ATOM^" 562 CZ TYRA 76 -20.427-52.626-22.0831.0050.30 A

A^FΘM 563 OH TYRA 7.6 -21-.496 -53.323 -21.570 1.0050.04 A

ATOM^" 564 C TYRA 76 -14.868 -5D.7-05 -24.8121.0056.57 A ATOM 565 O TYR-A 76 -15324 -50.335 -25.8941.0057.04 A

ATOM 566 N GLUA TT -13.572-50^56-24.5211.0057.80 A

ATOM .56.7 CA GLUA 77 -12.680-49:703-25.1721.0059.73 A

ATOM- 568 CB GLUA 77 -12.097-48.725-24.1491.0059.93 A

ATOM 569 CG GLUA 77 -12.093-47.276-24.6101.0061.42 A ATOM 570 CD GLUA 77 -10.766-46.858-25.2101.0062.11 A

ATOM 571 OEl GLUA 77 -10.164-45.886-24.708 1.0063.00 A

ATOM 572 OE2 GLU A 77 -10.323-47.502-26.185 1.0062.74 A

ATOM 573 C GLUA 77 -11.556-50.398-25.935 1.0060.64 A

ATOM 5740 GLUA 77 -10.852-49.772-26.7261.0061.52 A _m

ATOM 575 N PROA 78 -11.393-51.695-25.695 1.0061.01 A

ATOM 576 CD PROA 78 -11.494-52.204-24.316 1.0061.12 A

ATOM 577 CA PROA 78 -10.520-52.528-26.528 1.0060.53 A

ATOM 578 CB PROA 78 -9.875-53.475-25.5141.0059.65 A ATOM 579 CG PROA 78 -10.862-53.563-24.4071.0060.73 A

ATOM 580 C PROA 78 -11.312 -53.325 -27.560 JkOO 59.82 A

ATOM 581 O PROA 78 -10.735-54.110-28.313 1.0060.64 A

ATOM 582 N ILEA 79 -12.624-53.118-27.5871.0057.90 A

ATOM 583 CA ILE A 79 -13.522 -53.929^28.417 1.0055.78 A ATOM 584 CB ILEA 79 -14.293-54.952-27.5341.0054.00 A

ATOM 585 CG2 ILE A 79- -13.297-55.791 -26.734 r.OO 52.40 A

ATOM 586 CGT ILE A- 19 -15.250-54.213-26.583 1.0053.15 A

ATOM 587 CDlILEA 79 -16.078-55.128-25.688 1.0052.14 A

ATOM 588 C ILEA 79 -14J38 -53.172-29,2671.0055.56 A ATOM 589 O ILEA 79 -14,854-53.606-303801.0056.00 A

ATOM 590 N TRPA 80 -15.071-52.063-28.748 1.0055.26 A

ATOM 591 -CA TRPA 80 -16.033 -51.285 -29.528 1.0055.10 A

ATOM 592 CB TRPA 80 -16.476-50.014-28.769 l.Oσ 53.44 A

ATOM 593 CG TRPA 80 -15.518 -48.87S -28.890 1.0052.46 A ATOM 594 CD2 TRP A 80 -15.667 -47.715 -29.722 1.0052.02 A

ATOM 595 CE2 TRP A 80 -14.492-46.925-29.5671.0051.92 A

ATOM 596 CE3 TRP A 80 -16.6-76-47.262-30.5871.0050.25 A

ATOM 597 CDlTRPA 80^" -14.298.-48.756-28.2761,0052.46 A

ATOM 598 NEl TREA 80 -13:669-47.581-28.6821.0052.56- A ATOM -599 CZ2 TRP A 80 -44,302 -45.709 -3-0.244 1.0051Jl A

ATOM 600- GZ3 TRP A 80. -16.485 -46.048 -31.262 -11.00.49:92 A

ATOM 601 CH2TRPA 80 -15JL06 -45.287 -31.083 1.0049.97 A

ATOM 602 C TRPA 80 -15.229-50.939-30.7891.00-56.29 A

ATOM 603 O TRPA 80 -13.996-51.086-30.7991.0057.19 A ATOM 604 N GLNA 81 -15.910-50.478-31.838 1.0056.41 A

ATOM 605 CA GLNA 81 -15.247-50.173-33.120 1.0056.79 A

ATOM 606 CB GLNA 81 -13.815-49.648-32.952 1.0056.42 A

ATOM 607 CG GLNA 81 -13.674-48.181-32.610 1.0057.42 A

ATOM 608 CD GLNA 81 -12.196-47.785-32.4241.0058.57 A _m

ATOM 609 OElGLNA 81 -11.810-46.612-32.663 1.0060.36 A

ATOM 610 NE2 GLN A 81 -11.362-48.755-31.9991.0057.53 A

ATOM 611 C GLNA 81 -15.159-51.506-33.8481.0057.17 A

ATOM 6120 GLNA 81 -14.639-51.588-34.9641.0058.27 A ATOM 613 N ASNA 82 -15.646-52.552-33.1961-.00-56.91 A

ATOM 614 CA ASNA 82 -15.749-53.890-33.7741.0055.27 A

ATOM 615 CB ASNA 82 -14.704-54.815-33.2171.0055.80 A

ATOM 616 CG ASNA 82 -13.791-55.376-34.2691.0057.41 A

ATOM 617 ODlASNA 82 -14.046 -56.424 -34.824 r.OQ 58.53 A ATOM 618 ND2 ASN A 82 -12.739-54.665-34.5701.0057.16 A

ATOM 619 C ASNA 82 -17.072-54.449-33.4701.0054.15 A

ATOM 620 O ASNA 82 -17.333-55.573 -33.67-8 LOO 54.13 A

ATOM 621 N PHEA 83 -17.914-53.615-32.966 1.0053.32 A

ATOM 622 CA PHEA 83 -19.298-53.993-32.6821.0052.75 A ATOM 623 CB PHEA 83 -19.961-52.974-31.7441.0052.99 A

ATOM 624 CG PHEA 83 -19.451-53.012-30.3201.0053.49 A

ATOM 625 CDlPHEA 83 -18.467-53.921-29.9261.0053.30 A

ATOM 626 CD2 PHE A 83 -19.966-52.126-29.365 1.0053.02 A

ATOM 627 CElPHEA 83 -18.005-53.947-28.602 1.0052.91 A ATOM 628 CE2 PHE A 83 -19.513-52.141-28.041 1.0051.24 A

ATOM 629 CZ PHEA 83 -18.531-53.051-27.6591.00.52.10 A

ATOM 6JO C PHE A 83 -20.079 -54.046 -33.995 1.0051.90 A

ATOM 631 O PHEA 83 -19.841-53.24-1-34,8971.8052.34 A

ATOM 632 N THR A '84 -217009-54.990-34.093 1.0050:6-5 A ATOM 6-33 CA THRA 84 -21.821 -55.154 -.35.294 ITOO 4-9,65 A

ATOM 634 CB THRA 84 -22.723 -56391 -35.196 JLQO 50.02 A

ATOM 635 OGlTHRA 84 -2h929 -57.544 -34.897 ITQO 50.21 A

ATOM^' 636 CG2 THRA 84 -23.459 -56.6Q4 -36.5081.0050.80 A

ATOM 637 C THRA 84 -22.725-53.957-35.5561.00-48.61 A ATOM 638 O THRA 84 -22.694-53.376-36.638 LOG 47.86 A

ATOM 639 N ASPA 85 -23.529-53.605-34.5571.0048.44 A

ATOM 640 CA ASPA 85 -24.467-52.493-34.659 1.0048.10 A

ATOM 641 CB ASPA 85 -25.390-52.482-33.4441.0047.03 A

ATOM 642 CG ASP A 85 -26.481-51.455-33.566 1.0048.01 A _m

ATOM 643 ODlASPA 85 -27.418-51.465-32.7361.0048.68 A

ATOM 644 OD2ASPA 85 -26.399-50.630-34.4961.0048.69 A

ATOM 645 C ASPA 85 -23.752-51.153-34.773 1.0048.42 A

ATOM 646 O ASPA 85 -23.115-50.702-33.829 LOO 48.21 A ATOM 647 N PROA 86 -23.856-50.493-35.9361.0049.03. A

ATOM 648 CD PROA 86 -24.578-50.853-37.1671.0049.00 A

ATOM 649 CA PROA 86 -23.184-49.203-36.093 1.0049.13 A

ATOM 650 CB PROA 86 -23.457-48.841-37.553 1.0048.95 A

ATOM 651 CG PROA 86 -23.74r-50.169 -38.2071.0048.99 A ATOM 652 C PROA 86 -23.770-48.187-35.1241.0049.61 A

ATOM 653 O PROA 86 -23-040 -47.430 -34.491 1.0049.97 A

ATOM 654 N GLNA 87 -25.045-48.125-34.995 1.0050.12 A

ATOM 655 CA GLNA 87 -25.498-47.134-34.133 1.0051.27 A

ATOM 656 CB GLNA 87 -26.977-47.077-34.155 1.0051.50 A ATOM 657 CG GLNA 87 -27.490-46.342-35.3421.0054.67 A

ATOM 658 CD GLNA 87 -28.250-47.170-36.303 1.0057.26 A

ATOM 659 OEl GLNA 87 -29.052-47.962-35.905 1.0060.25 A

ATOM 660 NE2<ΪLNA 87 -28.015-46.992-37.5741.0057.43 A

ATOM ^61 C GLNA 87 -24.872-47.349-32.7941.0052.10 A ATOM 662 O GLNA 87 -24.246-46.491-32.313 1.0053.35 A

ATOM 663 N^" LEUA 88 -24.924 -48.523 -32.196 1.0051,21 A

ATOM 664 CA LEUA 88 -24.330-48.714-30.874 LOO 49.23 A

ATOM 665-CB LEUA 88 -24.393 -50.193 -3G.471 LQO 49.24 A

ATOM- 666 CG LEUA 88 -23.777 -50JS69 -29.1Φ1" 1.0049:77 A ATOM 667 CDl-LEUA 88 -24,507=50.073 -27.951 1.Θ048.62 A

ATOM 668 CD2 LEU A 88 -23.847 -52.13-5 -29.081 1.0050.00 A

ATOM 669 C LEUA 88 -22.896 -4«2O9 -30.7491,0048.48- A

ATOM 670 O LEUA 88 -22.607-47.400-29.8701.0049.03 A

ATOM 671 N ARGA 89 -21.994-48.665-31.6161.0047.79 A ATOM 672 CA ARGA 89 -20.612 -48.215 -31.5001.0047.24 A

ATOM 673 CB ARGA 89 -19.652-49.076-32.3491.0047.26 A

ATOM 674 CG ARGA 89 -19.785-49.008-33.8441.0048.24 A

ATOM 675 CD ARGA 89 -18.722-49.918-34.4761.0050.14 A

ATOM 676 NE ARGA 89 -18.695-49.851-35.941 1.0051.64 A _m

ATOM 677 CZ ARGA 89 -19.684-50.255-36.741 1.0051.94 A

ATOM 678 NHlARGA 89 -20.800-50.766-36.231 1.0052.24 A

ATOM 679 NH2 ARG A 89 -19.559-50.143-38.0581.0051.57 A

ATOM 680 C ARGA 89 -20.412-46.727-31.769 1.0045.67 A ATOM 681 O ARGA 89 -19.369-46.173-31.4261.0045.43 A

ATOM 682 N ARGA 90 -21.408 -46.07T -32.361 1.0044.45 A

ATOM 683 CA ARGA 90 -21.299-44.631-32.595 1.0044.51 A

ATOM 684 CB ARGA 90 -22.147-44.196-33.8141.0046.30 A

ATOM 685 CG ARGA 90 -21.398-44.291-35.1771.004920 A ATOM 686 CD ARGA 90 -22.317-44.118-36.4141.0049.75 A

ATOM 687 NE ARGA 90 -22.758-42.744-36.631 1.0050:61 A

ATOM 688 CZ ARGA 90 -22.255 -41.885 -37.5021.0049.63 A

ATOM 689 NHlARGA 90 -21.223-42.246-38.253 1.0049.15 A

ATOM 690 NH2 ARG A 90 -22.759-40.661-37.6271.0048.54 A ATOM 691 C ARGA 90 -21.738-43.898-31.3171.0042.92 A

ATOM 692 O ARGA 90 -21.363-42.750-31.083 1.0042.67 A

ATOM 693 N ILEA 91 -22.524-44.588-30.4891.0041.52 A

ATOM 694 CA ILEA 91 -23.009-44.047-29.2221.0038.47 A

ATOM 695 CB ILEA 91 -24.278-44.777-28.7141.0035.72 A ATOM 696 CG2 ILE A 91 -24.553-44.395-27.281 1.0034.23 A

ATOM 697 CGl ILEA 91 -25.479-44.405-29.572 1.0034.21 A

ATOM 698 CDI ILEA 91 -26.770 -44.960 -29DJ671.0032.27 A

ATOM 699 C ILEA 91 -21.921-44.234-28.1841.0018.12 A

ATOM 700 O ILEA 91 -21.547-43.295-27.491 1.0038.43 A ATOM 701 N ILEA 92 -21.445-4-5.486 -28.0591.0037.74 A

ATΘM 702-JCA ILEA 92 -2D.373 -45.747-27.1071.0038.22 A-

ATOM 703 CB ILEA 92 -19.958-47.230-27.155 1.0036.72^" A

ATOM 704 CG2 ILE A 92 -18.625-47.433-26.451 1.0035.58 A

ATOM 705 CGlILEA 92 -21.041-48.108-26.5251.0035.09 A ATOM 706 CDl ILE A 92 -20.615 -49.542 -26.3080.0035.60 A

ATOM 707 C ILEA 92 -19.164-44.857-27.3771.0038.61 A

ATOM 708 O ILEA 92 -18.522-44.341-26.498 1.0038.70 A

ATOM 709 N GLYA 93 -18.944-44.609-28.6961.0038.89 A

ATOM 710 CA GLYA 93 -17.838-43.758-29.095 1.0040.10 A _m

ATOM 711 C GLYA 93 -18.049-42.301-28.7261.0040.28 A

ATOM 7120 GLYA 93 -17.098-41.529-28.633 1.0039.96 A

ATOM 713 N ALAA 94 -19.304-41.920-28.521 1.0040.47 A

ATOM 714 CA ALAA 94 -19.642-40.553-28.1491.0040.27 A ATOM 715 CB ALAA 94 -21.064 -40.230 -28.583 1. JOO 40.56 A

ATOM 716 C ALAA 94 -19.520-40.418-26.643 1.0040.83 A

ATOM 717 O ALAA 94 -19.254-39.340-26.110 1.0041.36 A

ATOM 718 N VALA 95 -19.720-41.530-25.954 1.0041.07 A

ATOM 719 CA VALA 95 -19.639-41.534-24.5121.0041.37 A ATOM 720 CB VALA 95 -20.485-42.688-23.9341.0042.10 A

ATOM 721 CGlVALA 95 -20.365-42.728-22.4091.0042.19 A

ATOM 722 CG2 VAL A 95 -21.949-42.497-24.3461.0041.38 A

ATOM 723 C VALA 95 -18.194-41.630-24.0361.0041.51 A

ATOM 724 O VAL.A 95 -17.828-41.007-23.041 1.0040.85 A ATOM 725 N ARGA 96 -17.362-42.381-24.751 1.0041.72 A

ATOM 726 CA ARGA 96 -15.973-42.510-24.335 1.0042.44 A

ATOM 727 CB ARGA 96 -15.273-43.630-25.1241.0043.77 A.

ATOM 728 CG ARGA 96 -14.501-43.215-26.3601.0047.25 A

ATOM 729 CD ARGA 96 -13.413-44.257-26.653 1.0050.07 A ATOM 730 NE ARGA 96 -12.300-43.739-27.451 LOO 52.85 A

ATOM 731 CZ ARGA 96 -11.661-42.591-27.2141.0054.59 A

ATOM 732 NHl ARG-A 96 -10:657 -42.216 -27.9981.0055.63 A

ATOM 733 NH2 ARG A 96 -12.028-41.800-26.211 1.005531 A

ATOM 734 C ARGA 96 -15.2&4 -41.180 -24.431 1.0Θ 42,07 A ATOM 735 O ARGA 96 -14.075-41,060-23.943 1.0042.27 A

ATOM 736 N THRA- 97 -15.822-40.175-25.043 1.0041.50 A

ATOM 737 CA THRA 97 -15.187-38.867-25.1521.0041.17 A

ATOM 738 CB THRA 97 -15.441-38.200-26.516-1.0044.06 A

ATOM 739 OGlTHRA 97 -14.725-38.910-27.531 1.0041.49 A ATOM 74QCG2THRA 97 -14.965-36.749-26.5001.0040.26 A

ATOM 741 C THRA 97 -15.735-37.972-24.055 1.0040.87 A

ATOM 742 O THRA 97 -16.857-37.461-24.148 1.0039.84 A

ATOM 743 N LEUA 98 -14.913-37798-23.022 1.0040.81 A

ATOM 744 CA LEUA 98 -15.240-37.000-21.845 1.0040.71 A . _nβ

IUo

ATOM 745 CB LEUA 98 -14.229-37.300-20.7361.0040.95 A

ATOM 746 €G LEUA 98 -14.339-38.715-20.1571.0041.19 A

ATOM 747 CDlLEUA 98 -13.132-39.035-19.263 1.0040.57 A

ATOM 748 CD2 LEU A 98 -15.642-38.821-19.3791.0040.31 A ATOM 749 C LEUA 98 -15.307-35.496-22.0651.004030 A

ATOM 750 O LEUA 98 -16.164-34.812-21.4951.0040.27 A

ATOM 751 N GLYA 99 -14.406-34.974-22.882 1.0039.82 A

ATOM 752 CA GLYA 99 -14.417-33.548-23.1171.0040.31 A

ATOM 753 C GLYA 99 -13.775-32.844-21.943 1.0041.13 A ATOM 754 O GLYA 99 -12.667-33.200-21.5371.0040.81 A

ATOM- 755 N SERA1Θ0 -14.474 -31,-874 -21.3951.0041.93 A

ATOM 756 -CA SERAlOO -14.090-31.107-20:208-1.0042.37 A

ATOM 757 CB SERAlOO -15.121-30.066-19.965 1.0041.64 A

ATOM 758 OG SERAlOO -16.066-30.166-20.9771.0043.45 A ATOM 759 C SERAlOO -14.045-31.892-18.9681.0042.69 A

ATOM 760 O SERAlOO -13.487-31.483-18.0091.0043.42 A

ATOM 761 N ALAAlOl -14.687-33.015 -18.978 l.αo 41.83 A

ATOM 762 CA ALAA 101 -14.911-33.774-17.761 1,0040.33 A

ATOM 763 CB ALAAlOl -16.007-34.786-17.9741.0041.06 A ATOM 764 C ALAAlOl -13.663-34.462-17.2291.0039.60 A

ATOM 765 O ALAAlOl -13.655-34.903-16.0771.0039.24 A

ATOM 766 N ASN A 102 -12.6Θ6 -343*1 -18.025 LOO 38.65 A

ATOM 767 CA ASNA 102 -11.359-35,035-17.7441.0038.23 A

ATOM 768 CB ASNA 102 -10.537 -35.245 -18:958 1.0039.9J A - ATOM- 769 CG ASN A 102 -11.015 -36.205 -19.8T91.0040.76 A

ATOM 770 ODrASNA-102 -10.811 -37.351 -19.651 1.0042.53 A

ATOM 771 ND2ASNA.1O2 -11.504 -35-.749 -20.872 LOO-40.72 A

ATOM 772 C ASN A 102 -10.442-34.164-17.0241.0036.74 A

ATOM 773 O ASNA 102 -9.287-34.442-16.9371.0036.79 A ATOM 774 N LEU A 103 -10.939-33.058-16.583 1.0034.65 A

ATOM 775 CA LEUA 103 -10.129-31.997-16.0051.0032.93 A

ATOM 776 CB LEU A 103 -10.595-30.632-16.5091.0034.08 A

ATOM 777 CG LEUA 103 -10.469-30.233-17.9781.0035.00 A

ATOM 778 CDl LEU A 103 -11.447-29.100-18.270 1.0036.49 A _lrø

ATOM 779 CD2 LEU A 103 -9.043-29.800-18.2871.0034.67 A

ATOM 780 C LEU A 103 -10.361-32.049-14.5021.0031.83 A

ATOM 781 O LEUA 103 -11.482-32.272-14.053 1.0032.44 A

ATOM 782 N PRO A 104 -9.310^"-31.86I -13.6991.0030.30 A ATOM 783 CD ERO A 104 -7.882 -31.725 -14J023 1.0030.09 A

ATOM 784 CA PROA 104 -9327-31.895-12.2491.0028.80 A

ATOM 785 CB PROA 104 -8.133-31.632-11.6851.0029.17 A

ATOM 786 CG PRO A 104 -7.381-30.985-12.831 1.0030.47 A

ATOM 78TC PROA 104 -10.570-30.848-11.8241.0028.11 A ATOM 788 O PRO A 104 -10.755-29.839-12.5091.0026.88 A

ATOM 789 N LEU-A 105 -11.248-31.095-10.702 1.0028.53 A

ATOM 790 CA LEUA 105 -12.303-30:205-10.1961.0029.32 A

ATOM 791 CB LEU A 105 -12.632-30.530 -8.741 1.0029.17 A

ATOM 792 CG LEU A 105 -14.035-30.194 -8.208 1.0028.47 A ATOM 793 CDl LEU A 105 -13.925-30.027 -6.7081.0029.08 A

ATOM 794 CD2 LEU A 105 -14.601-28.939 -8.811 1.0026.46 A

ATOM 795 C LEU A 105 -12.005-28.713-10.285 1.0029.64 A

ATOM 796 O LEU A 105 -12.817-27.950-10.8071.0028.80 A

ATOM 797 N ALA A 106 -10.862-28.291 -9.748 1.0029.79 A ATOM 798 CA ALA A 106 -10.490-26.876 -9.779 1.0028.52 A

ATOM ^'799 CB ALAA-IOS -9.076-26.691 -9.245 1.0027.87 A

ATOM 800 G ALA A 106 -10.5-78-26.34041.201 LflO 28.31 A

ATOM 8Ot O- ALAA 106- -11.208 -25.309-11.45O 1.0027.60 A

ATOM÷ 802 N EYS A 107 -9.945 -27.062 -12.L24 LOO 27.85 A ATOM 803^"CA-LYSA 107 -9:911-26,698-13.5341.0025.63 A

ATOM 804 CB LYS A 107 -8.931 -27.609^14,261 1.0023.73 A

ATOM 805 CG LY-S-A 197 -7.494 -27.150 - 14.105^: 1.0020.29 A

ATOM 806 CD LYS A 107 -6.514 -2&.187 -14.5981.0018.99 A

ATOM^" 807 CE LYS A 107 -5.1-50-27.580-14.745 1.0017.99 A ATOM 808 NZ LYS A 107 -4.152-28.574-15.1761.0019.62 A

ATOM 809 C LYS A 107 -11.266-26.688-14.2371.0026.12 A

ATOM 810 O LYS A 107 -11.481-25.884-15.1391.0026.42 A

ATOM 811 N ARGA 108 -12.180-27.569-13.8481.0026.37 A

ATOM 812 CA ARG A 108 -13.497-27.555-14.4701.0027.13 A ATOM 813 CB ARG A 108 -14.385-28.674-13.945 1.0027.68 A

ATOM 814 CG ARG A 108 -13.895-30.063-14.241 1.0030.61 A

ATOM 815 CD ARG A 108 -14.904-31.058-13.7291.0033.36 A

ATOM 816 NE ARG A 108 -14.448-32.434.-13.8291.0034.98 A- ATOM- 817 CZ ARG A 108 -15.071 -33.447 -13.243 1.0037.21 A

ATOM 818 NHl ARGA 108 -1G.168 -33.215 -12.5221.003735 A

ATOM 819 NH2 ARG A 108 -14.608-34.687-13.371 1.0037.76 A

ATOM 820 C ARG A 108 -14.144-26.247-14.0941.0026.77 A

ATOM 821 O ARGA 108 -14.752-25.573-14.920 Lt)O 25.96 A ATOM 822 N GLN A 109 -14.003-25.899-12.8221.0028.19 A

ATOM 823 CA GLN A 109 -14.586 -24.683 -12.285 1.0036:1-1 A

ATOM 824 CB GLN A 109 -14324.-24.599 -10.781 1.0031.86 A

ATOM 825 CG GLN A 109 -15.095-25.639 -9.991 1.0034.48 A

ATOM 826 CD GLN A 109 -14.697-25.698 -8.523 1.0037.17 A ATOM 827 OEl GLNA 109 -13.516 -25.-824- -8.18T LOO 37.8O A

ATOM 82« NE2 GLNA 109 -15.689 -25.627 -7.645 1.0038.86 A

ATOM 829 C GLNA 109 -14.055 -23.460-12.993^" 1.0029.95 A

ATOM 830 O GLN A 109 -14.819-22.557-13.3271.0030.00 A

ATOM 831 N GLNAIlO -12.747-23.428-13.218 1.0029.25 A ATOM 832 CA GLNAIlO -12.140-22.304-13.925 1.002838 A

ATOM 833 CB-GLNAIlO -10,632-22.501-14,0661.00-27.82 A

ATOM 834 CG GLNAIlO -9.895 -2Z4Ϊ9 -12.755 1.0028773 A

ATOM 835 CD GLN A 110 -8.477 -22r899 -12.8721.0029.68 A-

ATOM -836 OEl GLNA 110 -7.-863 -2ZS03 -13.9391.00-30.04 A ATOM 837 NE2 GLNA 110 -7.931-23.406-11.769 1.0029:66 A

ATOM -83S C GLNAUO -12.785 --22.29-5 -15.293 1.0028.27 A

ATΘM 839 O GLNAIlO -13.296-21276 -15-150 1.0028.29 A

ATOM 840 N TYRAHl -12.773-23.454-15.933 1.0028.45 A-

ATOM 841 CA TYRAlIl -13.370-23.597-17.242 1.0029.1-1 A ATOM 842 CB TYRAlIl -13.489-25.078-17.601 1.0029.47 A

ATOM 843 CG TYRAlIl -13.825-25.354-19.049 1.0031.04 A

ATOM 844 CDl TYRA 111 -12.908-25.086-20.0691.0031.34 A

ATOM 845 CEl TYRA 111 -13.218-25.355-21.4071.0031.78 A

ATOM 846 CD2TYRA111 -15.061-25.893-19.401 1.0032.35 A ATOM 847 CE2 TYR A 111 -15.381-26.158-20.7271.0032.85 A

ATOM 848 CZ TYRAlIl -14.461-25.889-21.7271.0032.48 A

ATOM 849 OH TYRA 111 -14.807-26.147-23.038 1.0032.34 A

ATOM 850 C TYRAlIl -14.751-22.940-17.2171.0029.25 A ATOM 851 O TYRAlIl -14.931 -21.846 -L7.7571.0030.77 A

ATOM 852 N ASN A 112 -15.715-23.581-16.565 1.0027.39 A

ATOM 853 CA ASN A 112 -17.072-23.046-16.5121.0025.95 A

ATOM 854 CB ASN A 112 -17.905-23.848-15.5201.0027.89 A

ATOM 855 CG ASN A 112 -17.699-25.340-15.6661.0029.65 A ATOM 856 ODl ASNA 112 -17.919-25.911-16.733 1.0031.17 A

ATOM 837 ND2 ASN A 112 -17.270-25.982-14.5901.0031.16 A

ATOM 858 C ASNA 112 -17.166-21.552-16.183 1.0025.27- A

ATOM 859 O ASN A 112 -18.080-20.871-16.6461.0023.98 A

ATOM 860 N ALA A 113 -16.234-21.035-15.3861.0024.99 A ^" ATOM 861 CA ALA A 113 -16.255-19.613-15.0321.0024.81 A

ATOM 862 CB ALA A 113 -15.208-19.319-13.9871.0023.79 A

ATOM 863 C ALAA 113 -15.979-18.790-16.290 LOO 25.80 A

ATOM 864 O ALA A 113 -16.733-17.870-16.641 1.0024.90 A

ATOM 865 N LEU A 114 -14.885-19.130-16.966 1.0025.59 A ATOM 866 CA LEU A 114 -14.504-18.451-18.190 1.0024.87 A

ATOM &67 CB LEU A 114 -13.347-19.199-18.8441.0020^71 A,

ATOM 868 C<3 LEUA 114 -12.061 -19.135--18..Q19 1.0019.30 A

ATOM 869 CBl LEUA 114 -11.064-20.134 -18.530 LOO 19.65 A-

ATOM 870 CD2 LEU A 114 -11.4-75-17.739-18.0801.0019.14 A. ATOM 871 C LEUA-114- -15.717-18.393-19.123 1.0026.88 A-

ATOM 872 O LEU A 114 -16.132-17.315-19.553 1.00^{^}27.-99 A

ATOM 873 N LEU A 1115 -100749.543 -19.412 1.0027.38 A^{^}

ATOM 874 CA LEU A 115 -17.456 -19.584 -20288 LOO 27.82 A

ATOM 875 CB LEU A 115 -17.996 -21.012 -20.371 LOO 27.65 A ATOM 876 CG LEU A 115 -17.137-21.958-21.228 1.0027.67 A

ATOM 877 CDl LEU A 115 -17.620 -23.379 -21.1041.0027.70 A

ATOM 878 CD2 LEU A 115 -17.198-21.517-22.675 1.0028.16 A

ATOM 879 C LEU A 115 -18.567-18.595-19.9301.0029.10 A

ATOM 880 O LEU A 115 -18.958-17.787-20.7691.0030.86 A _π2

ATOM 881 N SERA 116 -19.077-18.617-18.703 1.0029.96 A

ATOM 882 CA SER A 116 -20.155-17.676-18.3801.0030.94 A

ATOM 883 CB SERA 116 -20.885-18.051-17.073 1.0030.73 A

ATOM 884 OG SERA 116 -19.988-18.277-16.015 1.0032.17 A ATOM 885 C SER A 116 -19.672-16.238-18.3321.0031.08 A

ATOM 8860 SERA 116 -20.460-15.317-18.512 1.0031.95 A

ATOM 887 N ASN A 117 -18.428-16.043-18.085 1.0031.34 A

ATOM 888 CA ASN A 117 -17.908-14.730-18.078 1.0033.07 A

ATOM 889 CB ASN A 117 -16.606-14.739-1773361.0034.95 A ATOM 890 CG ASN A 117 -16.774-14.639-15.883 1.0036.53 A

ATOM 891 ODl ASNA 117 -17.845 -14.748 -15.375 l.θθ-38.73 A

ATOM 892 ND2 ASN A 117 -15.716-14.374-15.203 1.0038.26 A

ATOM 893 C ASN A 117 -17.782-14.126-19.460 1.0032.72 A

ATOM 894 O ASN A 147 -18.392-13.142-19.725 1.0033.47 A ATOM 895 N MET A 118 -17.063-14.767-20.3801.0030.95 A

ATOM 896 CA META 118 -16.898-14.336-21.7571.0027.90 A

ATOM 897 CB MET A 118 -16.178-15.411-22.561 1.0025.75 A

ATOM 898 CG META 118 -14.756-15.652-22.1161.0025.90 A

ATOM 899 SB MET A 118 -13.750-16.503-23.346 1.0026.59 A ATOM 900 CE META 118 -14.410-18.166-23.235 1.0026.36 A

ATOM 901 C MET AlIE -18.244-14.021-22.389 1.0027.71 A

ATOM -902 O MET A 118 -18.427-12.963-22.97-81.0027.53 A

ATOM 903 N SER A 1-19 -19.L97 -14.93:0 -22.2551.0028^05 A

ATOM 904 CA SERA 119 -20.516 -14.690-22.835 LOO 29.9Φ A ATOM 905 CB-SER-A 119 -2L.421 -15.9Θ0 -22,6281,0030.86 A

ATOM 906 OG SERA 119 -21.835 -15.985 -21.276- KΘΘ-32.58 A-

ATOM 907 C SERA 119 -21.154 -13.468-22,192^" 1.0029.70 A

ATOM 908 O SER A 119 -21.998 -12Λ10 -22.801 1.0031.63 A

ATOM 909 N ARG A 120 -20.752-13.177-20.959 1.0028.16 A ATOM 910 CA ARGA 120 -21.290-12.042-20.222 1.0026.54 A

ATOM 911 CB ARG A 120 -21.063-12.224-18.716 1.0025.66 A

ATOM 912 CG ARGA 120 -21.868-11.263-17.8341.0025.14 A

ATOM 913 CD ARGA 120 -20.965-10.299-17.103 1.0024.89 A

ATOM 914 NE ARG A 120 -19.960-11.029-16.3471.0026.61 A ATOM 915 CZ ARG A 120 -18.762-10.545-16.051 1.0027.77 A

ATOM 916 NHl ARGA 120 -18.438 -9.325-16.452 1.0027.49 A

ATOM 917 NH2 ARG A 120 -17.886-11.286-15.3771.0028.41 A

ATOM 918 C ARGA 120 -20.614-10.774-20.6971.0026.24 A ATOM 919 O ARG A 120 -21.269 -9.767-20.9671.0026.86 A

ATOM 920 N ILE A 121 -19.294-10.822-20.7991.0025.93 A

ATOM 921 CA BLE A 121 -18.548 -9.670-21.2561.0026.42 A

ATOM 922 CB ILE A 121 -17.045 -9.957-21.2701.0024.74 A

ATOM 923 CG2 ILE A 121 -16.309 -8.848-22.0001.0023.96 A ATOM 924 CGl ILE A 121 -16.546-10.110-19.8341.0023.30 A

ATOM 925 CDl ILE A 121 -15.076-10.422-19.721 1.0023.70 A

ATOM 926 C ILE A 121 -19.010 -9.356-22.6621.0028.33 A

ATOM 927 O ILE A 121 -19.175 -8.195-23.031 1.0028.63 A

ATOM 928 N TYR A 122 -19.249-10.403-23.4391.0030.14 A ATOM 929 CA TYR A 122 -19.674-10.215-24.8071.0032.14 A

ATOM 930 CB TYRA 122 -19.659-11.536-25.571 1.0032.05 A

ATOM 931 CG TYRA- 122 -20.037-11.324-27.0121.0032.77 A

ATOM 932 CDl TYRA 122 -19.105-10.862-27.9361.0032.36 A

ATOM 933 CEl TYRA 122 -19.489-10.514-29.2281.0032.09 A ATOM 934 CD2 TYRA 122 -21.361-11.446-27.4231.0033.54 A

ATOM 935 CE2TYRA122 -21.750-11.098-28.7141.0033.15 A

ATOM 936 CZ TYRA 122 -20.81-4-10,630-29.6021.0031.88 A

ATOM 937 OH TYR A 122 -21.223 -10.244 -30.846 LOO 31.70 A

ATOM 938 C TYR-A.122^" -21.053 -9.589-24.955 1.00-33:94 A ATOM 9390 TYRA 122 -21.253 -8.72X-25.806 1.0033.72 A

ATOM -940 N SER A 123 -22.004-10.020-24.1341.0035.50 A

ATOM 941 CA- SER A 123 -23.361 -9.501 -24.2371.0037J0 A

ATOM 942 CB SER A 123 -24-360-10.644-24.0361.0038.28 A

ATOM 943 OG SER A 123 -24.221-11.631-25,0541.0041.46 A ATOM 944 C SERA 123 -23.716 -8.324-23.3261.0038.31 A

ATOM 9450 SER A 123 -24.865 -7.880-23.2891.0039.61 A

ATOM 946 N THR A 124 -22.736 -7.804-22.602 1.0038.42 A

ATOM 947 CA THR A 124 -22.983 -6.677-21.720 1.0038.79 A

ATOM 948 CB THR A 124 -22.378 -6.907-20.3301.0039.60 A ATOM 949 OGl THRA 124 -22.860 -8.140-19.801 1.0039.76 A

ATOM 950 CG2 THR A 124 -22.765 -5.778-19.382 1.0041.57 A

ATOM 951 C THRA 124 -22.320 -5.452-22.312 1.0039.15 A

ATOM 952 O THR A 124 -22.689 -4.327-22.000 1.0040.07 A ATOM 953 N ALA A 125 -21.332 -5.685--23.1671.0039.32 A

ATOM 954 CA ALA A 125 -20.577 -4.606-23.803 1.0039.33 A

ATOM 955 CB ALA A 125 -19.678 -5.177-24.893 1.0040.00 A

ATOM 956 C ALA A 125 -21.448 -3.500 -24.382 LOO 38.70 A

ATOM 957 O ALA A 125 -22.508 -3.761-24.953 1.0038.85 A ATOM 958 N LYS A 126 -20.989 -2.272-24.2341.0037.41 A

ATOM 959 CA LYS A 126 -21.712 -1.113-24.743 1.0037.86 A

ATOM 960 CB LYS A 126 -22.572 -0.492-23.641 1.00.35.30 A

ATOM 961 CG LYS A 126 -23.724 -1.372-23.1821.0034.52 A

ATOM 962 CD LYS A 126 -24.544 -0.689-22.1000.0034.72 A - ATOM 963 CE LYS A 126- -25.686 -1.574-21.6310.0034.81 A

ATOM 964 NZ LYSA 126 -26.490 -0.922-20.5600.0034.68 A

ATOM 965 C LYS A 126 -20.753 -0.071 -25.3091.0039J65 A

ATOM 966 O LYS A 126 -19.561 -0-.101 -24.9921.0039.71 A

ATOM 967 N VAL A 127 -21.274 0.811-26.1361.0041.52 A ATOM 96:8 CA VAL A 127 -20.477 1.874-26.731 1.0044.12 A

ATOM 969 CB VAL A 127 -20.497 1.806-28.2801.0042.32 A

ATOM 970 CGl VAL A 127 -19.818 3.030--28.86I 1.0041.94 A

ATOM 971 CG2VALA127 -19.787 0.556-28.755 1.0041.10 A

ATOM- 972- C VAL A 127 -21.052 3.213-26=2751.0047.43 A ATOM 973 O VAL A 127 -22.215 3.494-26.4801.0048.37 A-

ATΘM -974 N CYSA128 -20.210 4.035-25.6571.0051.05 A

ATOM 975 CA CYS A 128 -20-.649" 5.3-1-4-25.111 LOO 55.34 A

ATOM 976 C CYS A 128 -20.054 6.481-25.891 1.0058.26. A

ATOM 977 O CYS A 128 -18.947 6.386 -26.4201.0058.85 A ATOM 978 CB CYS A 128 -20.272 5.423 -23.632 1.0056.55 A

ATOM 979 SG CYS A 128 -20.762 4.000-22.630 1.0060.34 A

ATOM 980 N LEUA 129 -20.796 7.581-25.9571.0061.34 A

ATOM 981 CA LEUA 129 -20.387 8.735-26.749 1.0065.49 A

ATOM 982 CB LEU A 129 -21.611 9.471-27.298 1.0066.04 A ATOM 983 CG LEU A 129 -22.545 8.657-28.195 1.0067.33 A

ATOM 984 CDl LEUA 129 -23.193 7.525-27.412 1.0067.31 A

ATOM 985 CD2LEUA129 -23.602 9.552-28.825 1.0067.76 A

ATOM 986 C LEUA 129 -19.526 9.689-25.9301.0068.48 A ATOM 9870 LEUA 129 -19.660 9.768-24.7081.0069.09 A

ATOM -988 N PROA 130 -18.64210.413 -26.609 1.0071.24 A

ATOM 989 CD PRO A 130 -18.625 10.614-28.069 1.0071.65 A

ATOM 990 CA PRO A 130 -17.480 11.022-25.955 1.0073.58 A

ATOM 991^"CB PROA 130 -16.86911.879-27.065 1.0073.09 A ATOM 992 CG PROA 130 -17.261 11.189 -28.323 1.0072.62 A

ATOM^' 993 C PROA 130 -17.888 11.902 -24.778 1.0075.45 A

ATOM 9940 PRO A 130 -17.423 11.689-23.6581.007-6.25 A

ATOM 995 N ALA A 131 -18.75012.880-25.0351.0076.95 A

ATOM- 996 CA ALAA 131 -18.915 14.014-24.133 1.0078.20 A ATOM 997 CB ALA A 131 -18.756 15.323-24.8921.0078.57 A

ATOM 998 C ALAA 131 -20.26613.966-23.4281.0078.97 A

ATOM 999 O ALA A 131 -20.35014.155-22.2141.0079.61 A

ATOM 1000 N ALAA 132 -21.32013.711-24.1961.0079.44 A

ATOM 1001 CA ALA A 132 -22.523 13.084-23.662 1.0079.92 A ATOM 1002 CB ALAA 132 -23.54912.881-24.7661.0079.50 A

ATOM 1003 C ALAA 132 -22.04711.805 -22.979 1.0080.51 A

ATOM- 1004 O ALAA 132 -21,72910.817-23.642 1.0081.45 A

ATOM 1005 N ALAA-133 -22.00011.831-21.6521.0080.60 A

ATOM 1006 CA ALAA 133 -21.816- 10.616 -20.86-? M) 80.71 A ATOM 1007 GB -ALAA 133 -21.19010.939-19.519 1.0080.73 A

ATOM 1008 C ALAAJ33 -23.192 9.987 -20τ6791.0080.64' A

ATOM 1009 O ALA-A 133 -23:499 -9.446-19.616 1.0081.-87 A

ATOM 1010 N ALAA--134 -24.01810.061-21.718 1.0079.37 A

ATOM. 1011 CA ALAA 134 -25.338 9.442-21,6921.0077.64 A ATOM 1012 CB ALAA 134 -26.260 10.199-20,7481.0077.18 A

ATOM 1013 C ALAA 134 -25.943 9.376-23.091 1.0076.11 A

ATOM 1014 O ALAA 134 -25.92410.358-23.833 1.0075.64 A

ATOM 1015 N ALAA 135 -26.479 8.213-23.443 1.0073.99 A

ATOM 1016 CA ALA A 135 -26.035 6.955-22.855 1.0071.71 A _π6

ATOM 1017 CB ALAA 135 -26.716 6.725-21.515 1.0071.45 A

ATOM 1018 C ALAA 135 -26.298 5.783 -23.7961.0069.72 A

ATOM 1019 O ALA A 135 -26.801 5.965-24.9041.0069.55 A

ATOM 1020 N CYS A 136 -25.954 4.581-23.3471.0066.91 A ATOM 1021 CA CYS-A 136 -25.192 3.661 -^"24.1521.0063.04 A

ATOM 1022 C CYS A 136 -25.757 3.166 -25.4651.0060.52 A

ATOM 1023 O CYS A 136 -26.933 2.952-25.4961.0061.18 A

ATOM 1024 CB CYS A 136 -23.777 4.038-24.1371.0063.64 A

ATOM 1025 SG CYS A 136 -23.037^" 37962-22.5041.0063.19 A ATOM 1026 N TRP A 137 -24.998 2.925 -26.5401.0056.74 A

ATOM 1027 CA TRPA 137 -25:496 2.011 -27:5621,00-53.00 A

ATOM 1028 CB. TRPA 137 -24.915 2.372-28.930-1.0053.22 A

ATOM 1029 CG TRPA 137 -25.453 3.652-29.491 1.0052.74 A

ATOM 1030 CD2 TRP A 137 -24.817 4,505-30.4501.0053.34 A ATOM 1031 CE2TRPA137 -25.681 3.5-93-30.6851.0053.26 A

ATOM 1032 CE3 TRP A 137 -23.598 4.460 -31.137 LOO 53.76 A

ATOM 1033 CDl TRP A 137 -26.647 4.242-29.1901.0052.29 A

ATOM 1034 NEl TRPA 137 -26.792 5.408-29.903 1.0052.49 A

ATOM 1035 CZ2TRPA137 -25.368 6.620-31.573 1.0054.51 A ATOM 1036 CZ3 TRPA 137 -23.290 5.481-32.0171.0054.60 A

ATOM 1037 CH2 TRP A 137 -24.17T 6.546-32.228 l.OΘ 55.17 A

ATOM 1038 C TRP A 137 -25.159 0.564-27.215 1.0050.69 A

ATOM 1-039 O TRPA-137- -24.154 0.291 -26.5.59- 1.00-50.68 A

ATOM 1040 N SE-RA 128^~ -26.005 -0.359-27.661 1.0048^9 A ATOM 1041 CA SERA13S- -25.738 -1.781 -27-4961.0.047.22 A

ATOM 1042 CB SERA 138 -26.810 -2.427-26.6291.60-47.36- A

ATΘM 1043 OG SERA 138 -^8.039- -2.497-27.3381.0049.91 A

ATOM 1044 C SERA 138 -25.736 -2.476 -28.855_- 1.0046.23 A

ATOM 1045 O SERA 138 -26.389 -2.026-29,802 1.0046.74 A ATOM 1046 N LEU A 139 -25.000 -3.579-28.9481.0044.33 A

ATOM 1047 CA LEUA 139 -25.027 -4.415-30.1421.0043.44 A

ATOM 1048 CB LEUA 139 -24.104 -5.623-29.9741.0042.26 A

ATOM 1049 CG LEUA 139 -23.668 -6.320-31.2651.0041.48 A

ATOM 1050 CDl LEU A 139 -22.912 -5.357-32.1681.0040.20 A , , ₇

117

ATOM 1051 CD2 LEUA 139 -22.823 -7.546-30.956 1.0041.40 A

ATOM 1052 C LEUA 139 -26.445 -4.877-30.461 1.0044.09 A

ATOM 1053 O LEUA 139 -26.767 -5.175-31.6101.0044.26 A

ATOM 1054 N ALA A 140 -27.288 -4.934-29.4341.0044.75 A ATOM 1055 CA ALA A 140 -28.554 -5.652 -29r5221.0044.45 A

ATOM 1056 CB ALA A 140 -29.328 -5.523-28.218 LOO 45.62 A

ATOM 1057 C ALA A 140 -29.392 -5.152-30.692 1.0044.51 A

ATOM 1058 O ALAA 140 -29.687 -5.903-31.6221.0046.05 A

ATOM 1059 N PRO A 141 -29.774 -3.880-30.6401.0043.55 A ATOM 1060 CD PRO A 141 -30.362 -3.576 -29.3241.0042.16 A

ATOM 1061 CA PRO A 141 -30.522 -3.255 -31.7361.0042.50 A

ATOM 1062 CB PRO A 141 -3-U819 -2.813 -3L0581.0040.78 A

ATOM 1063 CG PRO A 141 -31.431 -2.567-29.6421.0041.73 A

ATOM 1064 C PRO A 141 -29.788 -2.044-32.301 1.0042.45 A ATOM 1065 O PRO A 141 -29.740 -1.863-33.5171.0042.34 A

ATOM 1066 N ASP A 142 -29.223 -1.225-31.4191.0042.51 A

ATOM 1067 CA ASPA 142 -28.560 0.015-31.8321.0041.53 A

ATOM 1068 CB ASP A 142 -28.075 0.769-30.5891.0043.54 A

ATOM 1069 CG ASPA 142 -29.108 0.776-29.4691.0045.42 A ATOM 1070 ODl ASP A 142 -30.251 1^".219 -29.728 1.0046.75 A

ATOM 1071 OD2ASPA142 -28.774 0.338--2&3371.0046.53 A

ATOM 1072 C ASP A 142 -27_^403 -0.089-32.829 L0040.21 A

ATOM 1073 O ASP A 142 -.27.522 0357-33.9741.0040.40 A

ATOM 1074 N LEU A 14T -26.278 -0.649-3-2.389 1.00-37.85 A ATOM 1075 CA LEU A 143 -25.116 -0J779 -33.255 1.0033.-85 A

ATOM 1-07-6- CB LEUA 143 -23:990 -1.524-323351.0032.00 A

ATOM 1O77 CG LEU A 143 -23.373^" -0.899 -31.282" 1.0O29.79 A

ATOM 1078 CDl LEUA 143 -22.148 -1.706-30.893 1.0029.29 A

ATOM 1079 CD2 LEU A 143 -22.981 0.540-31.5341.0028.65 A ATOM 1080 C LEUA 143 -25.457 -1.493-34.561 1.0032.65 A

ATOM 1081 O LEU A 143 -25.023 -1.069-35.6271.0031.77 A

ATOM 1082 N THR A 144 -26.238 -2.565-34.4891.0031.41 A

ATOM 1083 CA THR A 144 -26.595 -3.289-35.7061.0030.58 A

ATOM 1084 CB THRA 144 -27.569 -4.463-35.4481.0029.30 A ATOM 1085 OGl THRA 144 -26.921 -5.482-34.683 1.0026.22 A

ATOM 1086 CG2 THRA 144 -28.013 -5.060-36.7661.0029.15 A

ATOM 1087 C THRA 144 -27.256 -2.378-36.7241.0031.46 A

ATOM 1088 O THRA 144 -26.841 -2.330-37.882 1.0033.05 A ATOM 1089 N ASN A 145 -28.289 -1.662-36.2941.0031.21 A

ATOM 1O90 CA ASNA145 -29.002 -0.773-37.195 1.0030.28 A

ATOM 1091 CB ASNA 145 -30.184 -0.109-36.4791.0030.00 A

ATOM 1092 CG ASNA 145 -31.226 -1.127-36.0071.0031.64 A

ATOM 1093 ODl ASNA 145 -31.334 -2.224-36.5691.0030.95 A ATOM 1094 ND2 ASNA 145 -32.002 -0.765 -34.977 LOO 30.66 A

ATOM 1095 C ASNA 145 -28.084 0.277-37.7941.0029.79 A

ATOM 1096 O ASN A 145 -28.160 0.561 -38.fl89 1.0030.68 A

ATOM 1097 N ELE A 146 -27.203 0.845-36.978 1.0028.91 A

ATOM 1O98 CA ILE A 146 -26,282 1.863-37.4761.0027.87 A ATOM 1099 CB ILE A 146 -25.392 2.424-36.341 1.0026J7 A

ATOM 1100 CG2 ELE A 146 -24.606 3.626-36.8471.0025.00 A

ATOM UOl CGl ELE A 146 -26.262 2.854-35.158 1.0025.04 A

ATOM 1102 CDl ELEA 146 -25.485 3.403-33.9981.0022.52 A

ATOM 1103 C ILE A 146 -25.394 1.304-38.589 1.0027.70 A ATOM 1104 O ELE A 146 -25.043 2.017-39.522 1.0028.17 A

ATOM: IΓO5 N LEU A 147 -25.030 0.032-38.498 LOO 26.79 A

ATOM 1106 CA LEU A 147 -24.206 -0.565 -39.534 1.0026.74 A

ATOM 1107 CB LEUA 147 -23.448 -1,780-39,01-0- 1.0025.85- -A

ATOM^' 1108 CG^" LEU A 147 -22.169 -1.367 -3&299 170026.60 A ATOM- 1109-CDJLLEUA 14-7 -22.387 -1.440 -36.80© 1.0027.70 A

ATOM 1110 CD2 LEUA 147 -21.826, -2:264 -38:726 LOO 25.46 A

ATOM 1111 C LEUA 147 -25.071 -0.982 -40.6-94 LOG 27.42 A

ATOM 1112 O- LEUA 147 -24.642 -0.957-41.838 1.0028.47 A

ATOM 1113 N ALAA 148 -26.303 -1.356-40.391 1.0028.57 A ATOM 1114 CA ALAA 148 -27.230 -1.797-41.419 1.0028.61 A

ATOM 1115 CB ALA A 148 -28.420 -2.515-40.779 1.0027.26 A

ATOM 1116 C ALAA 148 -27.738 -0.679-42.315 1.0028.77 A

ATOM 1117 0 ALAA 148 -27.989 -0.916-43.490 1.0030.51 A

ATOM 1118 N SERA 149 -27.877 0.538-41.794 1.0028.61 A _m

ATOM 1119 CA SERA 149 -28.427 1.598 -42.625 1.0029.83 A

ATOM 1120 CB SERA 149 -29.940 1.638 -42.433 1.00 32.08 A

ATOM 1121 OG SERA 149 -30.264 1.661 -41.054 1.0035.97 A

ATOM 1122 C SERA 149 -27.890 3.014 -42.527 1.00 30.09 A ATOM 1123 O SERA- 149 -28.455 3.928-43.134 1.00 30.41 A

ATOM 1124 N SERA 150 -26.816 3.213 -41.776 1.00 30.03 A

ATOM 1125 CA SERA 150 -26.235 4.544 -41.664 1.0029.89 A

ATOM 1126 CB SERA 150 -25.566 4.738 -40.309 1.0028.85 A

ATOM 1127 OG SERA 150 -24.658 5.826 -40.363 1.00,29.04 A ATOM 1128 C SER A 150 -25.190 4.700 -42.745 1.00 30.56 A

ATOM 1129 0 SER A 150 -24345 3.820 -42.895 1.0.0 32.30 A

ATOM 1130 N ARGA 151 -25.238 5.808 -43.487 1.00 30.H) A

ATOM 1131 CA ARGA 151 -24.265 6.062 -44.556 1.0029.48 A

ATOM 1132 CB ARG A 151 -24.973 6.433 -45.857 1.0029.10 A ATOM 1133 CG ARGA 151 -25.201 5.261 -46.784 1.0027.67 A

ATOM 1134 CD ARGA 151 -25.751 4.058 -46.057 1.0026.00 A

ATOM 1135 NE ARGA 151 -26.422 3.1S7 -46.984 LOO 27.68- A

ATOM 1136 CZ ARG A 151 -26.752 1.901 -46.702 1.0029.23 A

ATΘM 1137 NHl ARG A 151 -27.368 1.159 -47.613 1.0029.67 A ATOM 1138 NH2 ARG A 151 -26.450 1.384 -45.520 1.00 29.14 A

ATOM 1139 C ARGA 151 -23.234 7.127 -44.233 1.0029.24 A

ATOM 1140 O ARGA 151 -22.654 7.735 -45.133 1.00 28.27 A

ATOM 1141 N SERA 152 -23.0-1-1 7.340 -42.943 Li)O 29.98 A

AXθM 1142 CA SERA 152 -22:030 8,3W -42.479 1.00-31.53 A ATOM L143 CB SERA-152. -22.532 9:029- -41.235 L-00-31.24" -A

ATOM 1144 OG SERA 152 -21.428 9,450 -40,454 1.00 32.43 A

ATOM 1145- C SER A 152 -20.754 7.575 -42.125 1.00-31,98 A

ATOM 1146 0 SERA 152 -20.731 6.812 -41.161 L00 33.79 A-

ATOM 1147 N TYRA 153 -19.693 7.812 -42.886 1.09 32.16 A ATOM 1148 CA TYRA 153 -18,427 7.125 -42.638 1.00 32.05 A

ATOM 1149 CB TYRA 153 -17.330 7.661 -43.567 1.00 30.78 A

ATOM 1150 CG TYRA 153 -16.021 6.906 -43.493 1.0030.24 A

ATOM 1151 CDl TYRA 153 -15.767 5.809 -44.319 1.00 28.08 A

ATOM 1152 CEl TYRA 153 -14.540 5.136 -44.261 1.0028.12 A _m

ATOM 1153 CD2 TYRA 153 -15.020 7.305-42.6041.0030.77 A

ATOM 1154 CE2 TYRA 153 -13.796 6.637-42.541 1.0029.39 A

ATOM 1155 CZ TYRA 153 -13.564 5.565-433691.0028.84 A

ATOM 1156 OH TYRA 153 -12.340 4.956-43.3061.0030.48 A ATOM 1157 C TYRA 153 -17.989 7.256-41.1821.0032.22 A

ATOM 11580 TYRA 153 -17.770 6.250-40.502 1.0031.46 A

ATOM 1159 N ALAA 154 -17.877 8.487-40.6971.0032.75 A

ATOM 1160 CA ALAA 154 -17.461 8.704-39.3191.0033.09 A

ATOM 1161 CB ALAA 154 -17.47210.183-38.9841.0033.13 A ATOM 1162 C ALAA 154 -18.357 7.949-38.3471.0033.88 A

ATOM 1163 O ALAA 154 -17.863 7.276-37.4361.0034.69 A

ATOM 1164 N META 155 -19.670 8L044 -38.5371.0034.13 A

ATOM 1165 CA META 155 -20.580 7.366-37.6291.0034.65 A

ATOM 1166 CB META 155 -22.023 7.650 -38.001 1.003637 A ATOM 1167 CG META 155 -22.961 7.246-36.8961.0039.93 A

ATOM 1168 SD META 155 -24.408 8.288-36.8751.0046.60 A

ATOM 1169 CE META 155 -25.720 7.070-37.1471.0045.28 A

ATOM 1170 C META 155 -20.338 5.863-37.5971.0034.24 A

ATOM 1171 O META 155 -20.213 5.261-36.521 1.0035.09 A ATOM 1172 N LEUA 156 -20.272 5.249-38.773 1.0032.59 A

ATOM 1173 CA LEUA 156 -20.018 3:818-38.8421.0031.17 A

ATOM 1174 CB LEUA 156 -19.966 3371-40.305 1.0030.51 A

ATOM 1175 CG LEUA 156 -2L242 3.68-2-41.094 1.0030.45 A

ATOM 1176 CDl LEUA 156 -20.962 3.623 -42.5791.003OrIO A ATOM 1177 CD2 LEU A 156 -22,341 2.711 -40.7041.0030τ97 A

ATOM 11-78 C LEUA 156- -18.679 3.545-38.143 1.00-30.43 A

ATOM 1179 O LEUA 156 -LS.551 2.595-37372 1.0030.53 A

ATOM 1180 N- LEUA 157 -17.691 4399-383941.002838 A

ATOM 1181 CA LEUA 157 -16375 4.226-37.791 1.0025.45 A ATOM 1182 CB LEUA 157 -15.427 5.322-38.273 1.0022.41 A

ATOM 1183 CG LEUA 157 -14.046 5.256-37.625 1.0021.22 A

ATOM 1184 CDl LEUA 157 -13.459 3.881-37.885 1.0019.32 A

ATOM 1185 CD2 LEUA 157 -13.143 6368-38.162 1.0017.85 A

ATOM 1186 C LEUA 157 -16.430 4.235-36.2671.0025.60 A _m

ATOM 1187 O LEUA 157 -15.715 3.483-35.6021.0024.45 A

ATOM 1188 N PHEA 158 -17.281 5.088-35.7101.0025.96 A

ATOM 1189 CA PHEA 158 -17.394 5.175-34.265 1.0026.41 A

ATOM 1190 CB PHEA 158 -18.243 6.381-33,863 1.0026.80 A ATOM 1191 CG PHEA 158 -18.208 6.669 -32.390 LOO 28.55 A

ATOM 1192 CDl PHEA 158 -17.053 7.170-31.7941.0028.95 A

ATOM 1193 CD2 PHE A 158 -19.310 6.391-31.582 1.0029.43 A

ATOM 1194 CEl PHE A 158 -16.995 7.383-30.418 1.0029.17 A

ATOM 1195 CE2 PHE A 158 -19.261 £605 -30.1971.0029.54 A ATOM 1196 CZ PHEA 158 -18.100 7.099-29.6181.0029.43 A

ATOM 1197 C PHE A 158 -17.980 3.895-33.671 1.0025.38 A

ATOM Ll-98 O PHEA 158 -17.543 3.424-32:623 1.0025.67 A

ATOM 1199 N ALAA 159 -18.964 3.326-34.3461.0022.91 A

ATOM 1200 CA ALA A 159 -19.569 2.L0.8 -33.8571.00^1.66 A ATOM 1201 CB ALA A 159 -20.922 1.924-34.491 1.00.20.98- A

ATOM 1202 C ALAA 159 -18.689 0.896-34.1381.0022.12 A

ATOM 1203 O ALAA 159 -18.649 -0.039-33.3491.0023.01 A

ATOM 1204 N TRP A 160 -17.987 0.894-35.2671.0021.57 A

ATOM 1205 CA TRP A 160 -17.134 -0.236 -35.602 LOO 19.02 A ATOM 1206 CB TRPA 160 -16.546 -0.084 -37.0081.0016.65 A

ATOM 1207 CG TRPA160 -15.862 -1.334-3-7.4641.0014.59 A

ATOM 1208 CD2 TJRP A 160 -14.509 -1.717-37.193 1.00.12.86 A.

ATOM 1209 CE2 TRP A 160 -14.330 -3.011-37.713 1.00-12.44 A

ATOM- 1210 CE3-TRPA160 -13.430 -LD9Ϊ -36.556 -13ΘΛ2.60 A AT^M 1211 CDl TRPA 160 -16.430.-2.378 -38.120 -1.0014.53. A

ATOM 1212 NEl TRPA 160 -15.520 -3.393 -38.273 1.0013J7.8 A

ATΘM 1213 CZ2 TRPA 160 -13.11-7 -3.696 -37.621 L-OO L1.68 A

ATOM 1214 CZ3 TRP A 160 -12^22 -1,773-36.4621.0013.49 A

ATOM 1215 CH2 TRP A 160 -12.078 -3.063-36.996 1.0013.10 A ATOM 1216 C TRPA 160 -16.001 -0.330-34.5881.0018.73 A

ATOM 1217 O TRPA 160 -15.690 -1.407-34.0801.0017.22 A

ATOM 1218 N GLUA 161 -15.391 0.818-34.311 1.0018.89 A

ATOM 1219 CA GLUA 161 -14.293 0.917-33.3501.0020.59 A

ATOM 1220 CB GLUA 161 -13.631 2.285-33.4661.0020.57 A ATOM 1221 CG GLUA 161 -12.363 2.478-32.679 1.0019.67 A

ATOM 1222 CD GLUA 161 -11.864 3.906-32.811 1.0023.41 A

ATOM 1223 OEl GLUA 161 -10.711 4.192-32.4321.0024.99 A

ATOM 1224 OE2 GLUA 161 -12.632 4.764-33.2971.0025.21 A ATOM 1-225 C GLU A 161 -14.838 0.735-31.933 1.0020.85 A

ATOM 12260 GLUA 161 -14.281 -0.016-31.128 1.0021.38 A

ATOM 1227 N GLY A 162 -15.928 1.431-31.635 1.0019.77 A

ATOM 1228 CA GLY A 162 -16.525 1.299-30.3291.0019.18 A

ATOM 1229 C GLY A 162 -16.738 -0.154-29.9501.0018.38 A ATOM 1230 O GLYA 162 -16.212 -0.625 -28.941 1.0018.23- A

ATOM 1231 N TRPA 163 -177499 -0.871-30.768 1.0017.70 A

ATOM 1232 CA TRPA 163 -17.788 -2.275-30.513 1.0018.49 A

ATOM 1233 CB TRPA 163 -18.734 -2.830-31.578 1.0018.18 A

ATOM 1234 CG TRPA 163 -18.950 -4.281-31.392 1.0018.34 A ATOM 123-5 CD2 TRP A 163 -19.613 -4.909-30.2901.0020.41 A

ATOM 1236 CE2 TRP A 163 -19.505 -6.311-30.4791.0020.44 A

ATOM 1237 CE3 TRP A 163 -20.288 -4.425-29.1581.0019.02 A

ATOM 1238 CDl TRPA 163 -18.484 -5.287-32.181 1.0019.93 A

ATOM 1239 NEl TRP A 163 -18.811 -6.516-31.641 1.0020.04 A ATOM 1240 CZ2 TRPA 163 -20.044 -7.227 -29.583 1.0020.0.0 A

ATOM 1241 CZ3 TJRFA 163 -20.820 -5.335 -28.2741.0020.37 A

ATOM 124ZCH2-TRPA163 -20.697 -6.725 -28.4901.0Θ- 21.38 A

ATOM 124-3 C TRPA-163 -16.578- -3.199 -30.418 LOO 17.96 A

ATΘM HM O TRPA 163 -16.540 -4.087-29:5-8-1 1.0017.36 A ATOM 1245 N- HIS A 164 -15.598 -2,994-31.2841.0018.34 A

ATOM 1246 CA HIS A 164 -14.413- -3:839 -31.295 1:00 L7.82 A

ATOM 1247 CB-JHISA 164 -13.650 -3.660-32:6041.0016.85 A

ATOM 1248 CG HIS A 164 -14.26-1 -4.400-33.744 1.0016.73 A

ATOM 1249 CDZHIS A 164 -13.885 -5.541-34.365 1.0017.16 A ATOM 1250 NDl HIS A 164 -15.445 -4.012 -34.3341.001712 A

ATOM 1251 CEl HIS A 164 -15.771 -4.883-35.271 1.0017.19 A

ATOM 1252 NE2 HIS A 164 -14.840 -5.821-35.3081.0018.43 A

ATOM 1253 C HIS A 164 -13.475 -3.659-30.124 1.0018.06 A

ATOM 1254 O HIS A 164 -12.782 -4.602-29.739 1.0019.00 A ATOM 1255 N ASNA 165 -13.417 -2.453-29.575 1.0017.86 A

ATOM 1256 CA ASNA 165 -12.571 -2.230-28.421 1.0018.54 A

ATOM 1257 CB ASNA 165 -12.261 -0.743-28.243 1.0019.00 A

ATOM 1258 CG ASN A 165 -11.290 -0.213-29.2801.0019.84 A ATOM 1259 ODl ASN A 165 -10r396 -0.928-29.748 1.0020.57 A

ATOM 1260 ND2 ASN A 165 -11.438 1.061-29.622 1.0018:82 A

ATOM 1261 C ASNA 165 -13.377 -2.740-27.2321.0018.66 A

ATOM 1262 O ASNA 165 -12.934 -3.595-26.4701.0018.73 A

ATOM 1263 N ALA A 1-66 -14.590 -2.229-27.113^{^}1.0018.96 A ATOM 1264 CA ALA A 166 -15.482 -2.596-26.032 1.0019.93 A

ATOM 1265 CB ALAA 166 -16:831 -1.950-26.266 LOO 2024 A

ATOM 1266 C ALA A 166 -15.664 -4.100-25.7921.0021.43 A

ATOM 12670 ALAA 166 -15.717 -4.541-24.6481.0022.01 A

ATOM 1268 N ALAA 167 -15.752 -4.893-26.855 1.0022.58 A ATOM 1269 CA ALA A 167 -15.977 -6.329 -26:7σθ 1.0022.94 A

ATOM 1270 CB ALAA 167 -16.909 -6.844 -27.S221.0021.51 A

ATOM 1271 C ALA A 167 -14.708 -7.152-26.6841.0022.80 A

ATOM 12720 ALAA 167 -14.594 -8.140-25.9481.0023.45 A

ATOM 1273 N GLYA 168 -13.746 -6.738-2X4921.0022.08 A ATOM 1274 CA GLY A 168 -12.523 -7.501-27.598 1.0021.25 A

ATOM 1275 C GLYA 168 -IL-49& -7.414-26.4951.0020.15 A

ATOM 12760 GLYA 168 -1 LlM- -8.419-25.867 LOO 19.24 A

ATOM 1227 N HJB A 469 -10.985-6.21 L:26.2741.0018.66- A

ATOM- 1278^"CA ILEA 169 -9.949 -5.993-25.287 h001-6,77 A ATOM 1279 CB ILEA 169 -9.762 -4,490-25.0461.00-14.93 A

ATOM- 1280 CG2 ILEA T69 -8-J39 -4.271 -23.8671.0016.10 A

ATOM 1281 CGMLE A 169 -9,199- -3.83-7_^26.313 1.0012.-45 A

ATOM 1282 -CDl ILRA 169 -9.185 -2.328-26.308 1.008.11 A

ATOM 1283 C ILE A 169 -10.120 -6.735 -23.9541.0017.46 A ATOM 1284 O DLE A 169 -9.T90 -7.415 -23.493 1.0016.93 A

ATOM 1285 N PROA 170 -11.304 -6.638-23.322 1.0017.31 A

ATOM 1286 CD PRO A 170 -12.531 -5.922-23.709 1.0017.07 A

ATOM 1287 CA PRO A 170 -11.490 -7.336-22.043 1.0017.22 A

ATOM 1288 CB PROA 170 -12.798 -6.761-21.5271.0015.27 A 4

ATOM 1289 CG PRO A 170 -13.555 -6.538 -22.7721.0017.40 A

ATOM 1290 C PRO A 170 -11.539 -8.853-22.1671.0017.28 A

ATOM 1291 O PROA 170 -11.133 -9.580-21.2631.0020.22 A

ATOM 1292 N LEUA 171 -12,028 -9.323 -23.3021.0016.32 A

ATOM 1293 CA LEU A 171 -12.170 -10744 -23.555 1.00-15.46- A

ATOM 1294 CB LEUA 171 -13.045-10.900-24.7991.0016,04 A

ATOM 1295 CG LEUA 171 -14.142-11.951-24.892 1.0017.35 A

ATOM 1296 CDl LEUA 171 -14.453-12.499-23.513 1.0018.46 A

ATOM 1297 CD2XEUA171 -15.372-11.311-25.5401.0016.09 A

ATOM 1298 C LEUA 171 -10.851 -1L513 -23.726 LOO 14.92 A

ATOM 1299 O LEUA 171- -10 J16 -12.638 -23.283 1.0014.35 A

ATOM 1300 N LYS A 172 -9.871-1-0.887-24.3521:0015.4.8 A

ATOM 1301 CA LYS A 172 -8.589-11.527-24.638 1.0015.25 A

ATOM 1302 CB LYS A 172 -7.578-10.479-25.1141.0015.19 A.

ATOM 1303 CG- LYS A 172 -6.358-11.052-25.799 1.0013.13 A

ATOM 1304 CD LYS A 172 -5.506 -9.950 ,26.373 1.0013.80 A

ATOM 1305 CE LYS A 172 -4.215 -10.505 -26.9321.0017.48 A

ATOM 1306 NZ LYS A 172 -3.317 -9.409-27.4091.0022.33 A

ATOM 1307 C LYS A 172 -7.941-12.403-23.576 1.0016.09 A

ATOM 1308 O LYS A 172 -7.716-13.585-23.8151.0016.40 A

ATOM 1309 N PRO A 173 -7.606 -11.842 -22.3971.00-T7-54 A

ATOM 1310 CD PRO A 173 -7.93S -10.515 -2L8521.0017.58 A

ATOM 1311 CA-FRO A 173 -6.977-12.676-2-1.361 LOO 16.61' A

ATOM 1312 CB PROJLT73 -6,850 -1-1.713 -20.1821.0044.04 A-

ATOM 131-3- CGr PRO A 173 -7.994--10.862 -20.3741.0014.8-r A-

ATOM 1314 C PRΘAΪ73- -7.782-13.94^-21,027 TOO 16.99^" A

ATOM 1315 O^" PROA 173- -7.212 -15τO3O -20.8661.0015.72 A

ATOM 1316 N LEU A 174 -9.103 -13.814. -20.94Q 1.0016.94 A

ATOM 1317 CA LEUA 174 -9.934-14.968-20.6531.0018.28 A

ATOM 1318 CB LEUA 174 -11.390-14.568-20.4361.001T.54 A

ATOM 1319 CG LEUA 174 -11.760-13.499-19.422 1.0016.03 A

ATOM 1320 CDl LEUA 174 -13.263 -13.575 -19.1901.0014.81 A

ATOM 1321 CD2 LEUA 174 -11.007-13.725-18.133 1.0019.24 A

ATOM 1322 C LEUA 174 -9.885 -15.981 -21.7971.0020.50 A ATOM 1323 O LEUA 174 -9.888-17.193-21.543 1.0022.07 A

ATOM 1324 N TYR A 175 -9.835-15.505-23.0491.0020.40 A

ATOM 1325 CA TYRA 175 -9.811-16.430-24.1721.0019.86 A

ATOM 1326 CB TYRA 175 -9.903-15.716-25.5261.0019.84 A ATOM 1327 CG TYRA 175 -10.312-16.689-26.6261.0022.29 A

ATOM 1328 CDl TYRA 175 -11.632-17.146-26.7181.0021.79 A

ATOM 1329 CEl TYRA 175 -11.999-18.124-27.6391.0020.79 A

ATOM 1330 CD2 TYR A 175 -9.366-17.245-27.5041.0021.75 A

ATOM 1331 CE2 TYRA 175 -9.733 -18.232-28.433 1.0021.02 A ATOM 1332 CZ TYRA 175 -11.053-18.663-28.4891.0020.85 A

ATOM 1333 OH TYRA 175 -11.449-1-9.625-29.391 1.0020.12 A

ATOM- 1334 C TYRA 175 -8.563-17.298-24.144 1.0019.71 A

ATOM 1335 O TYRA 175 -8.637-18.514-24.330 1.0018.68 A

ATOM 1336 N GLUA 176 -7.421-16.673-23.8991.0020.37 A ATOM 1337 CA GLUA 176 -6.157-17.397-23.8471.0022.98 A

ATOM 1338 CB GLUA 176 -5.021-16.446-23.4921.0021.56 A

ATOM 1339 CG GIJLJA 176 -4.980-15.194-24.331 1.0024.69 A

ATOM 1340 CD GLU A 176 -3.896-14.264-23.8571.0027.39 A

ATOM 1341 OEl GLUA 176 -3.195-14.658-22.895 1.0027.62 A ATOM 1342 OE2 GLUA 176 -3.739-13.159-24.430 1.0029.89 A

ATOM 1343 C GLU A 176 -6.206-18,517-22.8071.0024.35 A

ATOM 1344 O GLUA 176 -5.634-19.603-23.0161.0023.59 A

ATOM 1345 N ASP-A 177 -6.877 -18.242 -21.684 l,θθ 25.65 A

ATOM 1-346- CA ASPAlTT -3.994 -19r214 -20.6041.0026_^37 A ATOM 1-347 CB-ASP A 177 -7.384 -18,523-19.3001.0027.89 A

ATOM 1-34& CG ASP A 177 --6.198 -17.844 -ig,621 1.0029:60 A

ATOM 1349 ODl ASP A 177 -5.039 -T87151 -18:9921.0030τ03 A

ATOM 1350- OD2 ASP A 177 -6.428-17.018-17.7071.0029.64 A

ATOM 1351 C ASPA 177 -7.989-20.311-20.9341.0026.19 A ATOM 1352 O ASP A 177 -7.763 -21.480 -20.591 1.0026.80 A

ATOM 1353 N PHE A 178 -9.085-19.942-21.5941.0025.24 A

ATOM 1354 CA PHEA 178 -10.088-20.923-21.9901.0024.34 A

ATOM 1355 CB PHEA 178 -11.247-20.260-22.7341.0023.81 A

ATOM 1356 CG PHEA 178 -12.017-21.214-23.6021.0024.94 A ATOM 1357 CDl PHEA 178 -12.892-22.135-23.0371.0025.82 A

ATOM 1358 CD2 PHE A 178 -11.811-21.240-24.9871.0026.05 A

ATOM 1359 CEl PHE A 178 -L3.548 -23.073 -23.8291.0026.52 A

ATOM 1360 CE2PHEA178 -12.458-22.173-25.7961.0025.55 A ATOM 1361 CZ PHEA 178 -13.328-23.094-25.215 1.0027.71 A

ATOM 13ύ2 C PHEA 178 -9.428-21.928-22.9241.0023.93 A

ATOM 1363 O PHEA 178 -9.625-23.133-22.8071.0024.07 A

ATOM 1364 N THRA 179 -8.644-21.408-23.8591.0023.29 A

ATOM 1365 CA THRA 179 -7.967 -22.234 -24.831 1.0021.77 A ATOM 1366 CB THRA 179 -7227-21.358-25.843 1.0022.07 A

ATOM 1367 OGl THRA 179 -8.190-20.655-26.6341.0023.35 A

ATOM 1368 CG2 THR AJ 79 -6.350-22.195-26.743 1.0022.80 A

ATOM 1369 C THRA 179 -7.013-23.224-24.186 1.0021.05 A

ATOM 1370 O THRA 179 -7.020-24.400-24.523 1.0021.08 A ATOM 1371 N ALAA 180 -6.200 -22.771 -23.245 1.0020.85 A

ATOM 1372 CA ALAA 180 -5.267-23.683-22.6091.0020.51 A

ATOM 1373 CB ALAA 180 -4.475-22.965-21.549 1.0019.20 A

ATOM 1374 C ALAA 180 -6.041-24.837-21.9941.0021.84 A

ATOM 13750 ALAA 180 -5.694-26.003-22.185 1.0022.70 A ATOM 1376 N LEUA 181 -7.102-24.513-21.263 1.0022.15 A

ATOM 1377 CA LEU A 18-1 -7.896-25.552-20.625 1. OO 23.71 A

ATOM 1378 CB LEUA 181 -8.925-24.927-19.6771.00.22.43 A

ATOM 1379 CG LEUA 181 -8.309-24.446-1-8355 1.0023.09 A

ATOM 1380 JCBl-LEUA 181 -9.3-53 -23716 -17.51-01.00-24.25 A ATOM 13-8-1 CD2 LEUA 181 -7.733_^25.644-17.6021.00.19.40 A

ATOM 138-2 C LEUAtSl -^"8.578 -267484-21.623- 1.0024.68 A

ATOM- 138β O LEU A -181 -8.405-27.708-21.5591.00-24.19 A

ATOM 1384 N SERA 182 -9,340-25.905-22.5501.0026.24 A

ATOM 1385 CA SERA 182 -10.046-26.692-23.562 1.0027.19 A ATOM 1386 CB SERA 182 -10.627-25.785-24.653 1.0026.85 A

ATOM 1387 OG SERA 182 -11.620-26.471-25.399 1.0025.48 A

ATOM 1388 C SERA 182 -9.120-27.723-24.1881.0027.63 A

ATOM 1389 O SERA 182 -9.501-28.880-24.351 1.0028.48 A

ATOM 1390 N ASNA 183 -7.905-27.308-24.535 1.0027.62 A ATOM 1391 CA ASNA 183 -6.951-28.239-25.1221.0028.51 A

ATOM 1392 CB ASNA 183 -5.653-27.538-25.5191.0027.48 A

ATOM 1393 CG ASNA 183 -5.714-26.947-26.903 1.0026.22 A

ATOM 1394 ODl ASNA 183 -6.687-27.147-27.6261.0026.51 A

ATOM 1395 ND2 ASNA 183 -4.670 --26.220 -27.286 1.0025.36 A

ATOM 1396 C ASNA 183 -6.629-29.326-24.125 1.0029.14 A

ATOM 1397 O ASNA 183 -6.794-30.510-24.408 1.0031.09 A

ATOM 1398 N GLUA 184 -6.179-28.919-22.946 1.0029.46 A

ATOM 1399 CA GLUA 184 -5.824-29.880-21.9181.0029.59 A

ATOM 1400 CB GLUA 184 -5.642-29.191-20.5741.0028.57 A

ATOM 1401 CG GLU A 184 -5.186 -3O.160 -19.51.81.0030.32 A

ATOM 1402 CD GLUA 184 -5.170-29.544-18.151 1.0032.53 A

ATOM 1403 OEl GLUA 184 -6.159-28.862-17.8251.0036.27 A

ATOM 1404 OE2GLUAL84 -4.186-29J44 -17.405 1.0033.30 A

ATOM 1405 C GLUA 184 -O66 -30.972 -21.7781.0029.07 A

ATOM 1406 O GLUA 184 -6.530-32.145-21.623 1.0029.26 A

ATOM 1407 N ALAA 185 -8.133-30.586-21.842 1.0027.98 A

ATOM 1408 CA ALAA 185 -9.205-31.553-21.7021.0028.32 A

ATOM 1409 CB ALAA 185 -10.555-30.836-21.6601.0027.02 A

ATOM 1410 C ALAA 185 -9.195-32.607-22.8091.0028.74 A

ATOM 1411 O ALAA 185 -9.037-33.802-22.539 1.0028.55 A

ATOM 1412 N TYRA 186 -9.34-4 -32.162- -24.054 LOO 28.92 A

ATOM 1413 CA TYRA 186 -9.388 -33.076 -25.1991.0028.19 A

ATOM 1414 CB TYRA 186 -9.866--32JL43 -26=443 1.0023.52 A

ATOM 1415 CG TYRA 186 -11.304 -3L941 -26.3421.0021.10- A

ATOM 1416 CDiTYRA 186 -11.671--30.613 -26.173- 1.0020.Θ3 A

ATOM- 1417 CEl TYRA 186 -12.994-30.252-26.0591.0020.85 A

ATOM 1418 CD2 TYRA 186 -12.301-32.897-26.390 1X1021.19 A

ATOM 1419 CE2 TYRA 186 -13.623-32.549-26.271 1.0021.88 A

ATOM 1420 CZ TYRA 186 -13.968-31.229-26.1081.0021.84 A

ATOM 1421 OH TYRA 186 -15.299-30.904-26.001 1.0025.30 A

ATOM 1422 C TYRA 186 -8.083 -33.767 -25.4941.0029.57 A

ATOM 1423 O TYRA 186 -8.042-34.749-26.241 1.0029.52 A

ATOM 1424 N LYS A 187 -7.016-33.248-24.908 1.0030.88 A ATOM 1425 CA LYS A 187 -5.712-33.831-25.1071.0032.68 A

ATOM 1426 CB LYS A 187 -4.672-33.018-24.3571.0031.40 A

ATOM 1427 CG LYS A 187 -3.481-32.631-25.1941.0031.79 A

ATOM 1428 CD^" LYS A 187 -2.576-33.815-25.4161.0033.70 A ATOM 1429 CE LYS A 187 -1.212-33.363-25.913 1.0036.69 A

ATOM 1430 NZ LYS A 187 -0.573-32.366-25.003 1.0036.36 A

ATOM 1431 C LYS A 187 -5.813-35.239-24.5471.0033.95 A

ATOM 14320 LYS A 187 -5.274-36.186-25.128 1.0035.18 A

ATOM 1433 N ALAA 188 -6.564 -35.373- -23.453 1.0034.52 A ATOM 1434 CA ALA A 188 -6.755 -36.641 -.22.7591.0035.58 A

ATOM 1435 -CB ALAA 188 -7.217-36.399-21.3301.0035.35 A

ATOM 1436 C ALAA 188 -7.750-37.530-23.4981.0035.94 A

ATOM 14370 ALAA 188 -7.810-38.735-23.201 1.0036.53 A

ATOM 1438 N ASP A 189 -8.521 -36.969 -24.384 IJOO 35.63 A ATOM 1439- CA ASP A 1&9 -9.460-37.773-25.145 1.0034.84 A

ATOM 1440- CB ASP A 189 -10.725-36.977-25.4561.0035.18 A

ATOM 1441 CG ASPA 189 -11.688-36.959-24.291 1.0037.17 A

ATOM 1442 ODl ASP A 189 -12.012-38.062-23.7941.0039.05 A

ATOM 1443 OD2ASPA189 -12.120-35.860-23.8681.0037.85 A ATOM 1444 C ASP A 189 -8.779-38.246-26.4281.0034.33 A

ATOM 1445 O ASPA1S9 -9.413- -38.830 -27.3071.0034,30 A

ATOM 1446 ^"N GLYA 190 -7.476 -37.986 -26J29 LOO 33.17 A

ATOM 1447 GANGLY A 190 -6.729-38.425-27.691 1.0033.93 A

ATOM 1448 C GLYA 19Θ- -6,459 -37.466 -28τ852 U)O 343-8 A ATOM 1449 O- GLY A 190 -5.748-37.798-29.768 1.0033.03 A

ATOM 1450 N FHE-A 191 -7.127-36.29.7-28.8571.0033,48 A-

AIOM 1451 CA PHE A 191 -6.895 -35.372 -29:9561.0033.46 A

ATOM 1452 CB PHE A 191 -8.163-34.587-3.0.251 1.0034.42 A

ATOM 1453 CG PHE A 191 -9.387-35.452-30.4671.0036.71 A ATOM 1454 CDl PHE A 191 -10.078-35.996-29.382 1.0037.61 A

ATOM 1455 CD2 PHE A 191 -9.887-35.673-31.751 1.0036.64 A

ATOM 1456 CEl PHE A 191 -11.251-36.737-29.5701.0036.78 A

ATOM 1457 CE2 PHE A 191 -11.058 -36.413 -31.9491.0036.92 A

ATOM 1458 CZ PHEA 191 -11.741-36.944-30.8521.0037.59 A ATOM 1459 C PHEA 191 -5.745-34.434-29.5771.0033.90 A

ATOM 1460 O PHEA 191 -5.426-34.301-28.401 1.0034.85 A

ATOM 1461 N THR A 192 -5.111-33.790-30.553 1.0033.56 A

ATOM 1462 CA THRA 192 -3.982-32.906-30.2501.0032.85 A ATOM 1463 CB TKR-A 192 -3.248-32.468-31.5261.0033.17 A

ATOM 1464 OGl THRA 192 -2.710-33:616-32.179 1.0032.51 A

ATOM 1465 CG2 THRA 192 -2.107-31.499-31.193 1.0034.09 A

ATOM 1466 C THRA 192 -4.406-31.639-29.5341.0032.64 A

ATOM 1467 O THRA-192 -3.763^" -31.193-28.5741.003.3.35 A ATOM 1468- N ASP A 193 -5^".486-31.055-30.0341.0031.0I A

ATOM 1469 CA ASPA 193 -6.028-29.822-29.4971.0029.62 A

ATOM -1470 CB ASPA 193 -5.354-28.622 -3JO: 1691.0031.85 A

ATOM 1471 CG ASPA 193 -5.295-28.750-31.683 1.0034.55 A

ATOM 1472 ODl ASP A.193 -6.364-28.647-32.3361.0036.69 A ATOM 1473 OD2ASPA-193 -4.174-28.959-32.2171.0033.64 A

ATOM 1474 C ASP A 193 -7.507 -29v849 -29.810 1.0028.55 A

ATOM 1475 O ASP A 193 -7.971-30.759-30.4921.0028.38 A

ATOM 1476 N THRA 194 -8.254-28.873-29.3121.0026.56 A

ATOM 1477 CA THRA 194 -9.6S0 -28.856-29.5641.0025.02 A ATOM 1478 CB THRA 194 -10.355-27.722-28.8041.00-22.89 A

ATOM 1-479 OGl THRA 194 -9.754-27.607-27.51-5 1.0021.60 A

AIOM 1480 CG2 THRA 194- -11.834 -^"28..010 -28.6251.0022.30 A

ATOM 4481 C THR-A 194 -9.947 -28.707.-3 fe 056 -1.0025.03 A

ATOM 1482 Θ- THRA^~194 -11.006 -29.0S1--31.542 fcθO25L44 A- ATOM 1483 N GEYA-Ϊ95 -8.977 -2Sr-173-31.7841.0024.71 A

ATOM 1484 CA .GLYA 195 -9.154-27.995-33.213 1.0024.87 A

ATOM 1485 C -GEY^" A 195. -9.409-29.326-33.882 1.0024.39 A

ATOM 14860 GLYA 195 -10.394 -29.503- -34.612 1.0023.80 A

ATOM 1487 N ALAA 196 -8.514-30.27-2-33.623 1.0023.14 A ATOM 1488 CA ALAA 196 -8.631-31.604-34.195 1.0022.46 A

ATOM 1489 CB ALAA 196 -7.446-32.451-33.783 1.0021.22 A

ATOM 1490 C ALAA 196 -9.928-32.275-33.7661.0023.07 A

ATOM 1491 O ALAA 196 -10.559-32.968-34.5571.0023.22 A

ATOM 1492 N TYRA 197 -10.321-32.074-32.5121.0023.57 A ATOM 1493 CA TYRA 197 -11.548-32.667-32.0071.0023.71 A

ATOM 1494 CB TYRA 197 -11.723-32.374-30.5061.0021.55 A

ATOM 1495 CG TYRA 197 -13.102-32.745-29.9871.0019.57 A

ATOM 1496 CDl TYRA 197 -13.552-34.064-30.037 1.0017.58 A ATOM 1497 CEl TYRA 197 -14.841-34.395-29:6631,0017.81 A

ATOM 1498 CD2 TYRA 197 -13.988-31.764 -29333 1.00-17.97^" A

ATOM 1499 CE2 TYR A 197 -15.287-32.088-29.1561.0017.52 A

ATOM 1500 CZ TYRA 197 -15.702-33.406-29.2261.0019.36 A

ATOM 1501 OH TYRA 197 -16.979-33.745-28x8601.0021.39 A ATOM 1502 C TYRA 197 -12.738-32.111-32.783 1.0025.29 A

ATOM 1503 O TYRA 197 -13.667-32.819-33.131 LOO 26.51 A

ATOM 1504 N TJRP A- 198 -12.704 -30.8!2 -33.0461.0026.31 A

ATOM 1505 CA TRPA 198 -13.768-30.143-33.7771.0028.39 A

ATOM 1506 CB TRPA 198 -13.504 -28.643 -33.7-981.0029.93 A ATOM 1507 CG TRP A 198 -13.851-27.944-32.541 1.0029.91 A

ATOM 1508 CD2 TRP A 198 -13.854-26.531 -32.331 1.0Q 30.12 A

ATOM 1509 CE2 TRP A 198 -14257-26.308-30.996 1.0029.70 A

ATOM 1510 CE3 TRP A 198 -13.556 -25.429 -33.142 1.0029.59 A

ATOM 1511 CDl TRP A 198 -14.238-28.511-31.3641.0029.26 A ATOM 1512 NEl TRPA 198 -14.485-27.533-30.428 1.0029.22 A

ATOM 1513 CZ2 TRPA 198 -14.371 -Z5J26 -35.454 LOΘ-29.64 A

ATQM 1514 CZ3 TRPA 198 -13.669 -24.156 -32L603 1.0028.69 A

ATOM 1515 CH2 TRP A 198 -14^)73 -23.965-3-L-272 :L0029,30 A

ATOM^" 1516 C TRPA 198 -13.917 -30-643 -35221 1.0029.07 A - AT-ΘM 1517 O TRP A 198 -15.039-30.779-35.728-1.00-29.99 A-

ATΘM- 1518 N ARGA 199 -42.790-30,899-35.882 1.0027.49 A-

ATOM^" 1519 CA ARG A-199 -127819-31.380 -37.260_UOO 27.87 A

ATOM 1520 CB ARGA 199 -1L476 -31.086 -37.945 1.0027.08 A

ATOM.1521 CG ARGA 199 -11 J 05 -29:607 -37.977 LOO 26.10 A ATOM 1522 CD ARGA 199 -9.832-29.354-38.7601.0024.86 A

ATOM 1523 NE ARGA 199 -8.694-30.096-38.231 1.0024.73 A

ATOM 1524 CZ ARG A 199 -7.889-29.663-37.268 1.0025.61 A

ATOM 1525 NHl ARGA 199 -6.878-30.424-36.865 1.0024.88 A

ATOM 1526 NH2 ARG A 199 -8.083-28.467-36.7171.0027.52 A ATOM 1527 C ARGA 199 -13.149-32.882-37.375 1.0028.57 A

ATOM 15280 ARGA 199 -13.650-33.348-38.4121.0028.45 A

ATOM 1529 N SERA200 -12.883-33.640-36.313 1.0028.56 A

ATOM 1530 CA SER A 200 -13.150 -35.07L -36.3341.0028.62 A ATOM 1531 CB SER A 200 -12.630 -35.758^" -35.0491.0027.96 A

ATOM 1532 OG SER A 200 -13.445 -35.526-33.909 1.0625.96 A

ATOM 1533 C SER A 200 -14.634-35.351-36.520 1.0029.44 A

ATOM 15340 SER A 200 -15.020-36.480-36.825 1.0030.91 A

ATOM^" 1535 N TRP A 20,1 -15.463-34.325-36.3621.0029.47 A ATOM 1536 CA TRP A 201 -16.902-34.497-36.5021.0031.15 A

ATOM 1537 CB TRP A 201 -17.655-33.293-35.969 1.0032.45 A

ATOM 1538- CG TRPA 201 -17.537-33.076-34.515 L00J34.41 A

ATOM 1539 CD2 TRP A 201 -17.717-31.835-33.832 1.0036.18 A

ATOM 1540 CE2 TRP A 201 -17.598-32.097-32.4521,0036.64 A ATOM 1541 CE3TRPA201 -17.969-30.521-34.255 LOO 37.31 A-

ATOM 1542 CDl TRP A 201 -17.320-34.018-33.555 1.0035.12 A

ATOM 1543 NEl TRP A 201 -17.357 -33.439 -32.3081.0035 J9 A

ATOM 1544 CZ2 TRP A 201 -17.726 -31.096 -3L490 1.0038.14 A

ATOM 1545 CZ3TRPA2O1 -18.097-29.525-33.300 1.0038.49 A ATOM 1546 CH2 TRP A 201 -17.974-29.819-31.9321.0039.40 A

ATOM 1547 C TRP A 201 -17.377-34.731-37.9181.0032.29 A

ATOM 1548 O TRP A 201 -18.514-35.131-3:8.1221.0033,48 A

ATOM 1549 N TYRA 202 -16.531-34.464 -3&902 LOO 34.08- A

ATOM 1550^"CA TYR A 202 -1&945 -34:6?4 -40!285 1.0035.38 A ATOM 1551 CB TYR-A 202 -16.472-33.503-4-1.1521.0033,78 A

ATOM 1552 CGl TYR A 202 -t7.:GS4--32.-l 88 -40.717 1.0032.32^" A

ATOM 1553 CDl TYRA^02 -16.549-31.466-39:647 LOO 29:78 A

ATOM 1554 CEl TYR A 202 -17.145 -30.287 -39.2Θ11.0028J8 A

ATOM 1555 CD2TYRA202 -L8.238 -31.697-41.335 1.0032.06 A ATOM 1556 CE2TYRA202 -18.846-30.519-40.893 1.0030.70 A

ATOM 1557 CZ TYR A 202 -18.290-29.823-39.8291.0029.44 A

ATOM 1558 OH TYR A 202 -18.876-28.656-39.404 1.0029.12 A

ATOM 1559 C TYR A 202 -16.463-36.009-40.8271.0036.33 A

ATOM 1560 O TYR A 202 -16.789-36.396-41.9451.0036.92 A ATOM 1561 N ASNA203 -15.635-36.685-40.113 1.0037.74 A

ATOM 1562 CA ASN A 203 -15.179-37.941-40.5521.0039.33 A

ATOM 1563 CB ASN A 203 -16.231-38.969-40.431 1.0043.18 A

ATOM 1564 CG ASN A 203 -15.786-40.134-39.6581.0045.83 A ATOM 1565 ODl ASN A 203 -14.873-40.835-40.015 1.0047.58 A

ATOM 1566 ND2 ASN A 203 -16.40? -40.331 -38.566 1.0047.49 A

ATOM 1567 C ASN A 203 -14.805-37.915-41.902 1.0038.72 A

ATOM 1568 O ASN A 203 -15.382-38.509-42.7171.0038.77 A

ATOM 1569 N SER A 204 -13.722-37.285-42.132 1.0037.19 A ATOM 1570 CA SERA 204 -13.150-37.261-43.466 1.0035.18 A

ATOM 1571 CB SER A 204 -13.762-36.129-44.103 1.0036.26 A

ATOM 1572 OG SERA 204 -13.164-36.048-45.593 1.0037.84 A

ATOM 1573 C SERA204 -11.675-37.012-43.2691.0033.37 A

ATOM 15740 SER A 204 -1-1.274-35.949-42.815 1.0032.63 A ATOM 1575 N PRO A 205 -10.84.0-37.996-43.590 1.0032.65 A

ATOM 1576 CD PRO A 205 -11.074-39.290-44.248 1.0032,73 A

ATOM 1577 CA PRO A 205 -9.412-37.751-43.3971.0032.64 A

ATOM 1578 CB PRO A 205 -8.782-39.088-43.7671.0032.64 A

ATOM 1579 CG PRO A 205 -9.711-39.588-44.831 1.0033.78 A ATOM 1580 C PRO A 205 -8.948-36.626-44.301 1.0032.05 A

ATOM 1581 O PRO A 205 -7:885-36.040-44.1041.0032.56 A

ATOM 1582 N THR A 206 -9.731 -36.243 -45.2801.0O 31.92 A

ATOM 1583 CA THRA_206 -9-378 -35-135 -46.1871,0032.25 A

ATOM 1584 CB THR A 206 -9-539-35.537-47.596- 1.003X6J5 A ATOM 1585 OGl THR.A 206- -8:686 -36J634 -47T879 hθθ 37.55 A

ATOM 1586 CG2THRA206 -10,841 -36.058 -47.8361.Θ& 31=82 A

ATOM 1587 C THR A 206 -10.167 -33-869 -46.025 1,0030764 A

ATOM 1588 -O THR A- 206 -10.056-32.996-46.758 1.0030.14 A

ATOM 1589 N PHE A 207 -10.986 -33.797 -45.050 LOO 29.01 A ATOM 1590 CA PHE A 207 -11.760-32.580-44.738 1.00-27.83 A

ATOM 1591 CB PHE A 207 -12.092-32.559-43.231 1.0023.61 A

ATOM 1592 CG PHE A 207 -13.055-31.469-42.8141.0020.03 A

ATOM 1593 CDl PHE A 207 -14.247-31.263-43.502 1.0019.48 A

ATOM 1594 CD2 PHE A 207 -12.788-30.676-41.7071.0019.62 A ATOM 1595 CEl PHE A 207 -15.157-30.286-43.0951.0019.21 A

ATOM 1596 CE2 PHE A 207 -13.701-29.692-41.2941.0020.24 A

ATOM 1597 CZ PHE A 207 -14.884-29.503-41.993 1.0019.86 A

ATOM 1598 C PHE A 207 -11.152-31.220-45.134 1.0029.12 A ^" ATOM 1599 O PHEA.207 -11.700-30,509-45.975 1.0029.17 A

ATOM 1600 N GLU A 208 -10.035-30.851-44.513 1.0030.63^" A

ATOM 1601 CA GLU A 208 -9.385-29.570-44.791 1.0031.48 A

ATOM 1602 CB GLU A 208 -8.122-29.412-43.9321.0032.82 A

ATOM 1603 CG GLU A 208 -8.389 -29.079 -42.4691.0034.P6 A ATOM 1604 CD GLU A 208 -7.112-28.814-41.685 1.0037.11 A

ATOM 1605 OEl GLU A 208 -6A52 -27.781 -41.936 1.0039.09 A

ATOM 1606 OE2 GLU A 208 -6.764 -29.644 -40.8171.0037.55 A

ATOM 1607 C GLU A 208 -9.029-29.344-46.2541.0031.27 A

ATOM 160.80 GLU A 208. -9.201 -28.242 -46.7721.0Q 30.68 A ATOM 1609 N ASP A 209 -S.518 -30.377 -46.912 1.0031.49 A

ATOM 1610 CA ASP A 209 -8.151 -30.267 -48,3191.0031.77 A

ATOM 1611 CB ASP A 209 -7.342-31.494-48.761 1.0033.73 A

ATOM 1612 CG ASP A 209 -6.050-31.660-47.965 1.0035.68 A

ATOM 1613 ODl ASP A 209 -5.141 -30.811 -48.1141.0035.82 A ATOM 1614 OD2ASPA209 -5.953-32.637-47.180 l.OΘ 37.43 A

ATOM 1615 C ASP A 209 -9.414-30.134-49.1661.0031.09 A

ATOM 1616 O ASP A 209 -9.4:53 -29.343 -SQ.Ϊ201-0030.79^÷ A

AT-ΘM 1617 N ASP A 2LO -10.446 -30-.897 -48.8171.00-39.27 A

ATOM- 1618 CA ASPAJ2H)- -14.709 -30.821 -49.5371:0030.96 A ATOM 1619 CB ASPA 210 -12.710 -31.822 -4O_77 kθθ 32.23 A

ATOM 1620 £G ASP A 210 -12.234 -337251 -49.106 1.0036.73 A

ATOM- 1621 -ODl ASP A 210 -11.490-33.545-50.0691.0038.00 A

ATOM 1622 OD2 ASP A 210 -12.618 -34.ΘS5 -48.251 1.0039.18 A

ATOM 1623 C ASP A 210 -12.295-29.410-49.433 1.0031.77 A ATOM 1624 O ASP A 210 -12.963-28.937-50.353 1.0032.47 A

ATOM 1625 N LEUA211 -12.038-28.739-48.3121.0031.59 A

ATOM 1626 CA LEU A 211 -12.532-27.389-48.088 1.0029.86 A

ATOM 1627 CB LEUA 211 -12.525-27.059-46.598 1.0030.57 A

ATOM 1628 CG LEU A 211 -13.491-27.794-45.666 1.0030.22 A ATOM 1629 CDl LEU A 211 -13.291-27.280-44.237 1.0030.65 A

ATOM 1630 CD2 LEUA 211 -14.925-27.563-46.115 1.0030.10 A

ATOM 1631 C LEUA211 -11.688-26.375-48.8191.0029.78 A

ATOM 1632 O LEUA211 -12.210-25.411-49.3571.0029.06 A ATOM 1633 N GLUA212 -10.378-26.581-48.828 1.0030.65 A

ATOM 1634 CA GLU A 212 -9.494-25.651-49.5141.0032.04 A

ATOM 1635 CB GLU A 212 -8.021-25.971-49.250 1.0031.48 A

ATOM 1636 CG GLU A 212 -7.097-24.862-49.738 1.0034.76 A

ATOM 1637 CD GLU A 212 -5.613-25.156-49.5241.0037.96 A ATOM 1638 OEl GLU A 212 -4.779-24.226-49.665 1.0038.12 A

ATOM 1639 OE2 GLU A 212 -5.273-26.319-49.225 1.0040.5.6 A

ATOM- 1640 C GLU A 212 -9.773 -25.716 -51.011 1.0032.66 A

ATOM 1641 O GLUA212 -9.800-24.691-51.700 1.0031.82 A

ATOM 1642 N HIS A 213 -9.980 -26,933 -51.508 LQO 34.42 A ATOM 1643 CA HIS A 213 -10.286-27.140 -52.918 JLOO 35.64 A

ATOM 1644 CB HIS A 213 -10.339 -28.643 -53.235 1.003S.66 A

ATOM 1645 CG HIS A 213 -10.629-28.953-54.6771.00-44.15 A

ATOM 1646 CD2HISA213 -11.760-29.395-55.2861.0045.39 A

ATOM 1647 NDl HIS A 213 -9.684 -28.825 -55.6771.0046.46 A ATOM 1648 CELHIS A 213 -10.218-29.179-56.8361.0045.63 A

ATOM 1649 NE2 HIS A 213 -11.476-29.528-56.6251.0045.48 A

ATOM 1650 C HIS A 213 -1L651- -26.497 -53.183 1:0034.67 A

ATOM 1651 O HIS A 213 -11.813-25.721-54.1121.0035.37 A

ATOM 1652 N- LEU A 214 -12.629,--26.8I i -52.347 H)0:33-;40 A ATOM L653 CA LEUA214 -13.966-26265-52.5041.0032.39 A

ATOM 1654 CB-LEU-A 214- -14.865-26.777-51.3-78 1.0033.01 A

ATOM 1655 GG LEU A 214 -16.033 -27.684-51.753 JLOO 33τ48 A

ATOM 1656 CDl LEU A 214 -16.700-28.245-50.5121.0033.80 A

ATOM 1657 CD2 LEU A 214 -17.019-26.884-52.5841.0033.84 A ATOM 1658 C LEU A 214 -13.994-24.743-52.5221.0032.41 A

ATOM 1659 O LEUA 214 -14.870-24.152-53.148 1.0032.47 A

ATOM 1660 N TYRA215 -13.047-24.103-51.836 1.0031.93 A

ATOM 1661 CA TYRA215 -13.018-22.639-51.8021.0031.13 A

ATOM 1662 CB TYR A 215 -12.162-22.117-50.639 1.0029.43 A ATOM 1663 CG TYR A 215 -12.300-20.625-50.445 1.0026.75 A

ATOM 1664 CDl TYR A 215 -13.501-20.070-50.010 1.0026.25 A

ATOM 1665 CEl TYR A 215 -13.674-18.693-49.9361.0025.59 A

ATOM 1666 CD2 TYRA 2T5 -11.269-19.763-50.791 1:0026.05 A ATOM 1667 CE2 TYR A 215 -11.430-18.387-50.723 1.0024.66 A

ATOM 1668 CZ TYR A 215 -12.635-17.856-50.2991.0024.65 A

ATOM 1669 OH TYR A 215 -12.814-16.489-50.2671.0022.67 A

ATOM 1670 C TYR A 215 -12.509-22.028-53.108 1.0032.06 A

ATOM^' 1671 O TYRA 215 -13-.Θ78 -21.037-53.581 1.0033.33 A ATOM 1672 N GLN A 216 -11.442 -22.603 -53.678 1.00J 1.48 A

A-TOM 1673 CA GLN-A 216 -10.875-22.123-54.9461.00-30.38 A

ATOM 1674 CB GLN A 216 -9.804 -23.069 -55.4661.0032.17 A

ATOM 1675 CG GLN A 216 -8.593-23.241-54.5901.0036.67 A

ATOM 1676 CD GLN A 216 -7.585-24.185-55.2271.0039.16 A ATOM 1-677 OET GEN-A 216 -7.008 -23.871 -56.273 l.OΘ 42.34 A

ATOM 1678 NE2 GLN A 216 -7373-25.350-54.608 1.00-39.00 A

ATOM 1679 C GLN A 216 -11.957-22.030-56.013 1.0028.68 A

ATOM 1680 O GLN A 216 -12.018-21.062-56.7701.0028.67 A

ATOM 1681 N GLN A 217 -12.790-23.060-56.089 1.0026.10 A ATOM 1682 CA GLN A 217 -13.877-23,092-57.048 1.0024.85 A

ATOM- 1683 CB GLN-A 217 -14.706-24.354-56.8521.0026.43 A

ATOM 16-84- -CG GLN A 21-7 -14.118-25.587 -57.496 1.003.0.9-1 A

ATOM- 1685 CD GLN A 217 -14.96» -26.834 -57.274 l.θθ 34.33 A

ATOM,- 1686 OEl GLN A 217 -16.190-^6:814- -57.4471.00-34:46 A ATOM M87 NE2GLNA-217 -14.3J4 -27.935 -56.8971.0037.13 A

ATOM^" 1688 C GLN A 217 -14.7S8--21.89Θ -56.909 kθO 23.15 A.

ATOM 1689-O GLN A 217 -15.319 -21.393^~-57.8941.0023.64 A

ATOM 1690 N LEUA.218 -14.968-21.427-55.6781.0021.40 A

ATOM 1691 CA LEU A 2-18 -15.850-20.299-55.4061.0019.68 A ATOM 1692 CB LEU A 218 -16.653 -20.571 -54.126 LQD 19.60 A

ATOM 1693 CG LEUA218 -17.485-21.860-54.0071.0019.16 A

ATOM 1694 CDl LEU A 218 -17.764-22.162-52.5541.0020.40 A

ATOM 1695 CD2 LEU A 218 -18.781-21.717-54.749 1.0019.39 A

ATOM 1696 C LEU A 218 -15.160-18.941-55.290 1.0019.45 A ₁₃

ATOM 1697 O LEUA218 -15.796-17.915-55.5161.0020.36 A

ATOM 1698 N GLUA219 -13.872-18.912-54.9591.0017.63 A

ATOM 1699 CA GLU A 219 -13.195-17.624-54.8101.0017.26 A

ATOM 1700 CB GLU A 219 -11.667-17.769-54.6921.0018.09 A ATOM 1701 CG GLU A 219 -10:99,7-16407-54.393 1.0020.56 A

ATOM 1702 CD GLU A 219 -9.559 -1615Ql -53.863 1..00"24.3S A

ATOM 1703 OEl GLU A 219 -9.140-15.580-53.111 1.0025.10 A

ATOM 1704 OE2GLUA219 -8.844-17.474-54.204 1.0026.01 A

ATOM 1705 C GLU A 219 -13.4-98-16.609-55:9021.00 HS.81 A ATOM 1706 O GLU A 219 -13.770-15.450-55.603 1.0015.63 A

ATOM 1707 N PRO A 220 -13.456-17.026-57,183-1.0017.05 A

ATOM 1708 CB PRO A 220 -13.126-18.365-57.701 1.001^.40 A

ATOM 1709 CA PRO A 220 -13.730-16.114-58.298 1.0015.17 A

ATOM 1710 CB PRO A 220 -43,701-17.032-59.5061.0014.61 A ATOM 1711 CG PROA220 -12.723-18.053-59.1091.0015.77 A

ATOM 1712 C PRO A 220 -15.077-15.443-58.128-1.0014.32 A

ATOM 1713 O PRO A 220 -15.251-14.274-58.475 1.0012.98 A

ATOM 1714 N LEUA 221 -16.025-16.196-57.582 1.0012.90 A

ATOM 1715 CA LEU A 221 -17.362-15.678-57.363 1.0013.21 A ATOM 1716 CB LEU A 221 -18.258-16.755-56.7561.0012.43 A

ATOM 1717 CG LEU A 221 -13.442 -17.271 -57.568 1.0010.59 A

ATOM 1718 CDl LEU A 221 -Ϊ&.9316 -1-8.069 --58.7421.0011.21 A_

ATOM 1719 CD2 LEU A 221 -2O.320 -18.133 -56.695.1.00-10.88 A

ATOM 1720 C LEUA.221-- -171300-14.486 -56.435 1.0014.12 A ATOM- 1721 O LEU A 221 -17.85Q--13.429 --56.746- 1.0015.39 A

ATOM 1722 N TYR A 222 -16.623-14.656-55.299-1.00-14.17 A

ATOM 1723 CA TYR A 222 -16:493 -13J87 -54.3121.0014.92 A

ATOM 1724- CB TYR A 222 -15.769-14.077-53.049 l.θθ-14.94 A

ATOM 1725 CG TYR A 222 -15.613-12.997-51.9961.0015.02 A ATOM 1726 CDl TYR A 222 -16.726-12.406-51.420 1.0014.51 A

ATOM 1727 CEl TYR A 222 -16.595-11.392-50.4971.0014.97 A

ATOM 1728 CD2 TYR A 222 -14.357-12.540-51.6121.0014.88 A

ATOM 1729 CE2 TYR A 222 -14.214-11.519-50.681 1.0013.42 A

ATOM 1730 CZ TYRA 222 -15.338-10.952-50.128 1.0014.66 A _o7

ATOM 1731 OH TYR A 222 -15.222 -9.957-49.1851.0014.60 A

ATOM 1732 C TYR A 222 -15.742-12.397-54.8771.0015.63 A

ATOM 1733 O TYRA 222 -16.262-11.291-54.8841.0015.35 A

ATOM 1734 N LEU A 223 -14.516-12.631-55.3361.0016.33 A ATOM 1735 CA LEU A 223 -13.681-11.582 -55.911 1-00-17:18 A-

ATOM 1736 CB LEU A 223 -12.520-12.199-56.681 1.0017.93 A

ATOM 1737 CG LEU A 223 -11.505-12.977-55.853 1.0019.84 A

ATOM 1738 CDl LEU A 223 -10.408-13.506-56.7801.0021.41 A

ATOM 1739 CD2LEUA223 -10.909-12.079-54.776 1.002OrOl A ATOM 1740 C LEU A 223 -14.452-10.647-56.841 1.0017.64 A

ATOM 1741 O LEU-A 223 -14.187 -9.440-56.872 1.0016.48 A

ATOM 1742 N ASN A 224 -15.397 -1L198 -57.6001,0.018.65 A

ATOM 1743 CA ASN A 224 -16.176-10.374-58.503 1.0020.39 A

ATOM 1744 CB ASN A 224 -16.752 -11.199 -59.6481.002L74 A ATOM 1745 CG ASN A 224 -15.840 -11.199 -60.864- 1.0024-.90- A

ATOM 1746 ODl ASN A 224 -15.636-10.161-61.521 1.0025.95 A

ATOM 1747 ND2 ASN A 224 -15.264-12.358-61.160 1.0026.25 A

ATOM 1748 C ASN A 224 -17.268 -9.613-57.791 1.0020.79 A

ATOM 1749 O ASN A 224 -17.481 -8.429-58.081 1.0022.75 A ATOM 1750 N LEU A 225 -17.967-10.261-56.863 1.0019.82 A

ATOM 1751 CA LEU A 225 -18.994 -9.537-56.11-8- OO LS.61 A

ATOM 1752 CB LEU A 225 -19.674 -10.452 -55.0981.00 Ϊ6J99 A

ATOM 1753 CG LEUA'225 -.20,771 -9.750-54.293 1.0617:82 A

ATOM 1754 CD LLEU A 225 -2 O27 -9.178 -^"55.243 1.0015:88- A ATOM 1755- €D2 LEU A 225 -21.385-10.727-53.300 1.00-17.0-9- A

ATOM 1756 C LEU A 225 4-8.277 -8.38-5 -553901. OG 1-7.52 A

ATOM 1757 O LEU A 225 -18.796--7.282 -55.253 1.0016:16 A

ATOM- 1758 N HIS A 226 -17.061 -8.679 -.54.9501.0017.71 A

ATOM 1759 CA-HIS A 226 -16.215 -7.747 -.54.2361.001S.86 A. ATOM 1760 CB HIS A 226 -14.933 -8.466-53.801 1.0019.59 A

ATOM 1761 CG HIS A 226 -13.997-7.618-52.999 1.0020.50 A

ATOM 1762 CD2 HIS A 226 -13.465 -7.801 -51.7701.0020.55 A

ATOM 1763 NDl HIS A 226 -13.449 -6.449-53.481 1.0021.68 A

ATOM 1764 CEl HIS A 226 -12.617 -5.952-52.585 1.0021.11 A , „

138

ATOM 1765 NE2 HIS A 226 -12.608 -6.753-51.5381.0020.14 A

ATOM 1766 C HIS A 226 -15.885 -6.503-55.0581.0019.34 A

ATOM 1767 O HISA226 -16.320 -5.410-54.705 1.0020.11 A

ATOM 1768 N ALA A 227 -15.122 -6.649-56.143 1.0019.62 A ATOM 1769 CA ALA A 227 -14.765 -5.490 -56.9741.0019.73 A

ATOM 1770 CB ALA A 227 -13.999 -5.950-58.203 1.0017.75 A

ATOM 1771 C ALA A 227 -15.980 -4.635-57.391 1.0019.72 A

ATOM 17720 ALA A 227 -15.884 -3.405-57.465 1.0018.83 A

ATOM 1773 N PHE A 228 -17.114 -57295-57.6391.0018.98 A ATOM 1774 CA PHE A 228 -18.360 -4.641-58.0491.0019.35 A

ATOM 1775 CB PHEA22S -19.403 -5.707 -58r4091.0020.24 A

ATOM 1776 CG PHE A 228 -20.707 -5.148 -58.931 1.0022.58 A

ATOM 1777 CDl PHE A 228 -20.804 -4.640-60.2241.0022.95 A

ATOM 1778 CD2PHEA228 -21.853 -.5.159 -58.1371.0023.62 A ATOM 1779 CEl PHE A 228 -22.029 -4.155-60.721 1.0022.86 A

ATOM 1780 CE2 PHE A 228 -23-.074 -4.680 -58.6221.0023.72 A

ATOM 1781 CZ_PHEA228 -23.161 -4.178-59.9171.0023.32 A

ATOM 1782 C PHE A 228 -18.914 -3,740-56.9571.0019.51 A

ATOM 1783 O PHE A 228 -19.348 -2.624-57.2181.0020.82 A ATOM 1784 N VAL A 229 -18.914 -4.244-55.7291.0018.14 A

ATOM 1785 CA ΥAL A 229 -19.407 -3.489 -54.5921.0016.73 A

ATOM 1786 CB VAL A 229 -19.636 -4.403-53.3771.0017.01 A.

ATOM 1787 CGl VAL A_229 -19.956 -3.567 -52J461.0016,68 A

ATOM 1788-CG2VALΑ229 -20.773 -5.313 -53.675 kθO 15^8 A ATOM 1789 C VAL A 229. -18393 -2,427-54.2291.0016r22 A

ATOM 1790 O VAL A 229 -18.746 -1.30i- -53:9241.0015.22 A

ATOM 1791 N ARGA230 -17.124^~-2.79T-54.2671.0016.84 A

ATOM 1792 CA ARG A 230 -16.073 -1.850-53.948 1.0018.2S A

ATOM 1793 CB ARG A 230 -14.692 -2.486-54.1171.0016.72 A ATOM 1794 CG ARG A 230 -13.549 -1.565-53.7041.0017.78 A

ATOM 1795 CD ARG A 230 -12.196-2.240-53.8441.0020.55 A

ATOM 1796 NE ARG A 230 -1L911 -2.616 -55.224 1.0022.59 A

ATOM 1797 CZ ARG A 230 -10.983 -3.499-55.572 1.0022.87 A

ATOM 1798 NHl ARG A 230 -10.253 -4.099-54.649 1.0022.74 A ATOM 1799 NH2 ARG A 230 -10.791 -3.791-56.845 1.0026.21 A

ATOM 1800 C ARG A 230 -16.206 -0.652-54.878 1.0019.38 A

ATOM 1801 O ARG A 230 -15.901 0.480-54.496 1.0020.34 A

ATOM 1802 N ARG A 231 -16.658 -0.897-56.1041.0019.18 A ATOM 1803 CA ARG A 231 -16.833 0.196-57.048 1.0019.52 A

ATOM 1804 CB ARG A 231 -17.038 -0.341-58.473 1.0022.02 A

ATOM 1805 CG ARG A 231 -17.794 0.599-59.424 1.0023.90 A

ATOM 1806 CD ARGA231 -16.992 1.814-59.835 1.0024.71 A

ATOM 1807 NE ARCTA231 -16.221 1.551-61.040 1.0028.82 A ATOM 1808 CZ ARG A 231 -15.664 2.489-61.8021.0030.31 A

ATOM 1809 NHl ARG A 231 -14.979 2.142-62.8861.0030.Jl A

ATOM 1810 NH2 ARGA 231- -15.798 3.772-61.4841.0030.50 A

ATOM 1811 C ARGA231 -18.043 1.000-56.5941.0018.41 A

ATOM 1-812 O ARG A 231 -17.957 2.207-56.4141.0016.85 A ATOM 1813 N ALA A 232 -19.165 0.327-56.395 1.0018.30 A

ATOM 1814 CA ALA A 232 -20.367 1.016-55.950 1.0019.22 A

ATOM 1815 CB ALA A 232 -21.460 0.021-55.6471.0018.29 A

ATOM 1816 C ALA A 232 -20.071 1.854-54.7071.0020.02 A

ATOM 1817 O- ALA A 232 -20.560 2.974-54.581 1.0020.83 A ATOM 1818 N LEUA233 -19.273 1.318-53.785 1.0020.27 A

ATOMT 1819 CA LEU A 233 -18.948 2.053^" -52.568 LOO 20.99 A

ATOM 1820^" CB LEU A 233 -£8.268 1.148-51.5301.0021.27 A

ATOM 1821 CG LEUA233 -19.198. 0.240-50.7091.002L28 A

ATOM 1822 CDl LEU A 233 -18.391 -0.572.-49.7221.0021,97 A ATOM 1823 CD2LEUA233 -20.232 1.074 -49.972:_1.0020^87 A

ATOM 1824 C LEU A- 233^' -18.ff84 3.272-52.853 1.0021.85 A

ATOM 1825 O LEU A 233 -18.303 4.338 -52.280 LOQ 22.22 A

ATOM 1826 N HIS A 234 -17.1-04 3.120-53.734 1.0023.04 A

ATOM 1827 CA HIS A 234 -16.240 4,242-54.094 1.0024.21 A ATOM 1828 CB HIS A 234 -15.310 3.831-55.241 1.0023.12 A

ATOM 1829 CG HIS A 234 -14.398 4.919-55.715 1.0024.28 A

ATOM 1830 CD2 HIS A 234 -13.137 5.253-55.3451.0025.28 A

ATOM 1831 NDl HIS A 234 -14.749 5.807-56.7081.0025.58 A

ATOM 1832 CEl HIS A 234 -13.745 6.639-56.931 1.0025.62 A ATOM 1833 NE2 HIS A 234 -12.754 6.324 -56.118 1.0024.61 A

ATOM 1834 C HIS A 234 -17.145 5.394 -54.525 1.00 26.31 A

ATOM 1835 O HIS A 234 -17.010 6.536 -54.066 1.0026.73 A

ATOM 1836 N. ARG A 235 -18.095 5.061 -55.391 1.00 28.34 A ATOM 1837 CA ARO A 235 -19.063 6.010 -55.925 1.00-29.79 A

ATOM 1838 CB ARG A 235 -20.129 5.247 -56.710 1.00 30.15 A

ATOM 1839 CG ARG A 235 -20.588 5.924 -57.981 1.00 35.12 A

ATOM 1840 CD ARG A 235 -20.542 4.948 -59.173 1.00 38.02 A

ATOM 1841 NE ARG A 235 -21.241 3.693 -58:880 1.00 42.20 A ATOM 1842 CZ ARGA 235 -21.171 2.592 -59.632 1.0043.47 A

ATOM 1843 NHl ARG A 235 -20.430 2.580 -60.742 1.0042.94 A

ATOM 1844 NH2 ARG A 235 -21.827 1.491 _^59.258 LOO 44.85 A

ATOM 1845 C ARG A 235 -19.738 6.869 -54.858 1.0030.19 A

ATOM 1846 0 ARG A 235 -20.067 8.023 -55.115 1.00 31.22 A ATOM 1847 N ARGA 236 -19.933 6.31-3 -53.662 1.00 30.20 A

ATOM 1848 CA ARG A 236 -20.617 7.031 -52.582 1.0029.55 A

ATOM 1849 CB ARG A 236 -21.591 6.076 -51.879 1.00 28.72 A

ATOM 1850 CG ARG A 236 -2L603 6.173 -50.363 1.0029.76 A

ATOM 1851 CD ARG A 236 -22.687 7.107 -49.824 1.0030.73 A AIOM 1852 NE ARGA 236 -24.047 6.662 -50.144 1.00 30.46 A

ATOM 1853 CZ ARG A 236 -25.147 7.105 -49:533 1.00 29.88 A

ATOM 1854 NHLARG A-236 -25.05.7 8.006 -48.559^* 1.Q0 29.80 A

ATOM 1855 NH2 ARG A236 -26.338 6.657 -49.902 1.0028.85- A

AT-OM 185^'6 C ARG A 236 -1-9.747. 7.738-51.545 1.0028.16 A ATOM 1857 0 ARG A 2315 -20.078 8.834 -51.112 1.00 22JUS A-

ATOM 1858- N TYR A 237 -18^645 7.11S -51,144 1.0027.62^" A

ATOM 1859 CA TYR A 237 -17.778 7.727^50.140 1.00 27.49 A

ATOM 1860 CB TYR A 237 -17.281 6.681 -49.146 1.0025.75 A

ATOM 1861 CG TYR A 237 -18.401 5.983 -48.419 1.0024.79 A ATOM 1862 CDl TYR A 237 -18.678 4.641 -48.667 1.00 24.20 A

ATOM 1863 CEl TYR A 237 -19.705 3.993 -48.023 1.00 23.82 A

ATOM 1864 CD2 TYRA 237 -19.195 6.665 -47.497 1.00 23.05 A

ATOM 1865 CE2 TYRA 237 -20.236 6.022 -46.845 1.0023.34 A

ATOM 1866 CZ TYRA 237 -20.482 4.679 -47.114 1.0024.38 A ATOM 1867 OH TYR A 237 -21.485 3.994 -46.465 1.00 25.67 A

ATOM 1868 C TYR A 237 -16.597 8.445 -50.745 1.00 27.96 A

ATOM 1869 0 TYRA 237 -15.905 9.201 -50.067 1.0027.80 A

ATOM 1870 N GLY A 238 -16.347 8.194 -52.022 1.00 28.93 A ATOM 1871 CA GLY A 238 -15.254 8.884 -52.670 1.00 30.62 A

ATOM^" 1872 C GLY A 238 -13.929 8.180 -52.823 1.00 31.40 A

ATOM 1873 0 GLYA 238 -13.807 6.981 -52.630 1.00 31.57 A

ATOM 1874 N ASP A 239 -12.920 8.972 -53.157 1.00 32.87 A

ATOM 1875 -CA ASP A 239 -11.583 8.472 -53.407 1.00 34.23 A ATOM 1876 CB ASP A 239 -10.965 9.2S9 -54.533 1.00 35.99 A

ATOM 1-87-7 CG ASP A 239- -9.996 8.482 -55.350 1.00 39.51 A

ATOM 1878 ODi- ASP A 239 -10.449 7.482 -55.970 1.0040.93 A

ATOM 1879 OD2 ASP A 239 -8.790 8.842 -55.358 1.00 41.81 A

ATOM 1880 C ASP A 239 -10.639 8.456 -52.2 LO 1.0034.21 A ATOM 1881 O ASP A 239 -9.596 7.795 -52.249 1.00 33.86 A

ATOM -L882 N ALAA 240 -10.997 9J87 -51.157 1,0034.02 A

ATOM 1883 CA ALA A 240 -10.175 9.238 -49.954 1.00 32.33 A

ATOM 1884 CB ALA A 240 -10.491 10.490 -49.146 1.00 32.59 A

ATOM 1885 C ALA A 240 -10.410 8.003 -49.095 1.00 31.67 A ATOM 1886 O ALA A 240 -9.465 7.442 -48.547 1.00 3 L77 A

ATOM 1887 N TYR A 241 -11.664 7.568 -49.000 1.00 30.56 A

ATOM^" T888 CA TYR A 241 -11.996 6.430.-48.167 1.00 30.16 A

ATOM- 1889 -CB-TYR A 241 -13.308 6.700 -47.447 1.00 33.72 A

ATOM 1890 CG TYR A241 -13.199 7.863 -46.493 1. QO 38.47 A ATOM mi .CDl TYR A^"241 -14.240 8.778 -46.348 1.00 39.86 A

ATOM 1-892 GEl- TYR A 24-1- -14.1O5 9.906 -45.534" 1. OO 42:05 A

ATOM 1893 CD2 TYR-A 241 -12.014 8.097 -45.788 1.00 40.-76 A

ATOM 1894 CE2 TYR A 241 -11.867 9.224 -44.976 1.00 42.77 A

ATOM 18-95 CZ TYRA 241 -12.913 10.127 -44.855 1.00 43.05 A ATOM 1396 OH TYR A 241 -12.755 11.264 -44.084 1.0044.78 A

ATOM 1897 C TYRA 241 -12.036 5.075 -48.833 1.00 29.36 A

ATOM 1898 O TYRA 241 -11.894 4.060 -48.151 1.00 29.97 A

ATOM 1899 N DLE A 242 -12.243 5.023 -50.145 1.0027.23 A

ATOM 1900 CA ILE A 242 -12.247 3.728 -50.822 1.0024.93 A ATOM 1901 CB ELE A 242 -13.614 3.416 -51.468 1.0023.59 A

ATOM 1902 CG2 ILE A 242 -13.531 2.112 -52.246 1.0022.19 A

ATOM 1903 CGl ILE A 242 -14.701 3.283 -50.395 1.00 23.82 A

ATOM 1904 CDl ILE A 242 -14.634 1.996 -49.572 1.0023.69 A ATOM 1905 C ILE A 242 -11.158 3.664 -51.890 1.00 24.88 A

ATOM 1906 O DLE A 242 -11.O46 4554 -52.726 1.0025.34 A

ATOM 1907 N ASN A 243 -10.343 2.614 -51.839 1.0025.53 A

ATOM 1908 CA ASN A 243 -9.262 2.420 -52.800 1.00 24.99 A

ATOM 1909 CB ASN A 243 -7.993 1.968 -52.093 1.0023.45 A ATOM 1910 CG ASNA 243 -6.866 1.702 -53.048 1.00 22.10 A

ATOM 1911 OD1 ASN-A243 -7:079 1.242 -54:164 1.0024.32 A

ATOM 1942 ND2 ASN A 243 -5.650 r.972 -52.613 1.0020.21 A

ATOM 1913 C ASN A 243 -9.690 1.345 -53.789 1.0025.06 A

ATOM 1914 0 ASN A 243 -9,888 0.184 -53.408 1.0024.68 A ATOM 1915 N LEUA244 -9.819 1.744 -55.054 1.0023.94 A

ATOM 1916 CA LEU A 244 -10.248 0.848 -56.125 1.0024.23 A

ATOM 1917 CB LEU-A 244 -10.497 1.669 -57.394 1.00 24.31 A

ATOM 1918 CG LEU A 244 -11.687 2.621 -57.325 1.0023.51 A

ATOM 1919 CDl LEU A 244 -11.731 3.523 -58.545 1.0023-41 A ATOM 1920 CD2 LEU A 244 -12.962 1.805 -57.209 IUO 23.41 A

ATOM 1-921 -C JLEU A 244 -9.281 -0.305 -56.420 1.0024.46 A

ATOM 1922 O LEU A 244 -9,556 -L169 -57.255 1.0025.01 A

ATOM 1923 N -ARGA^245 -8.158 -.0308-55.756 1.00 24.99 A

ATOM 1-924 CA ARG A 245 -7.172 -1.326 -55.891 1:00.26.08 A ATOM. 1925 OB^" ARG A 245 -5.9-90^" -0.689 -56,467 1.00 29.72 A

ATOM^" -1-926 JGG ARG A 245 -5.7-26 -0:908 -57:869 1-0033.61^" A

ATOM 1927 CD -ARG-A245 -5.639 0.310 -58τ543 LOT) 37.88 A

ATOM 1928 NE ARGA 245^" -4.312 0.63-2 -58.987 1.0041.48 A

ATOM 1929 CZ ARG A 245 -3.65-1 1.666 -58.567 1.0043.64 A ATOM 1930 NKl ARG A 245 -4.188 2.451 -57.661 1.0045.14 A

ATOM 1931 NH2 ARG A 245 -2.462 1.921 -59.032 1.0042.67 A

ATOM 1932 C .ARG A 245 -6.697 -1.827 -54.575 1.0025.61 A

ATOM 1933 O ARGA245 -5.640 -2.313 -54.516 1.0025.99 A

ATOM 1934 N GLY A 246 -7.462 -1.622 -53.508 1.0023.55 A ATOM 1935 CA GLY A 246 -7.100 -2.060-52.1761.0021.78 A

ATOM 1936 C GLY A 246 -8.263 -2.749-51.506 1.0020.67 A

ATOM 19370 GLY A 246 -9.354 -2.775-52.073 1.0022.09 A

ATOM 1938 N PRO A 247 -8.077 -3.305-50.2961.0018.33 A ATOM 1939 CD PROA 247 -6.892 -3:206 -49.4261.0016.92 A

ATOM 1940 CA PRO A 247 -9,162 -3.989-49.6021.0017.28 A

ATOM 1941 CB PRO A 247 -8.452 -4.638-48.4361.0015.74 A

ATOM 1942 CG PRO A 247 -7.435 -3.639-48.0941.0016.89 A

ATOM 1943 C PRO A 247 -10.170 -2:961 -49.1671.001Ε749 A ATOM 19440 PRO A 247 -9.819 -1.797-48,985 1.0019.02 A

ATOM 1945 N ILE A 248 -11.424 -37377-49.021 1.0019,95 A

ATOM 1946 CA ILEA 248. -12.486 -2.462 -48.5971.0020.23 A

ATOM 1947 CB ILE A 248 -13.865 -3.024-48.9341.0017.37 A

ATOM 1948 CG2 ILE A 248 -14.922 -2.037-48.5421.0016.91 A ATOM 1949 CGl ILE A 248 -13.936 -3.378-50.4141.O0 T6.65 A

ATOM 1950 CDl BLE A 248 -15.157 -4.196-50.7941.0015.12 A

ATOM 1951 C DLE A 248 -12.429 -2.288-47.085 1.0021.54 A

ATOM 19520 ELEA248 -12.104 -3.230-46.369 1.0023.11 A

ATOM 1953 N PRO A 249 -12.727 -1.081-46.580 1.0022.23 A ATOM 1954 CD PRO A 249 -12.834 0.173-47.3471.0022.95 A

ATOM 1955 CA PRO A 249 -12.713 -0.803 -45.134 1.0022.55 A

ATOM 1956 CB PRO AJZ49 -12.881 0.710-45τO691.0024.10 A

ATOM 1957 CG.PRO.A249 -12-273 1.17-9-46.3771.0023-.02 A.

ATQM 195-Sτ-C PRO A 249 -13.874 -1,562^{^}-447451 1.0021.70 A- ATGM 1959 O -PROA-249 -15.035 -1.330-44:7554.0021.66 A

ATOM^" 1960 N ALA A 250 -137525 -2.442~43.5171.0021.79 A

ATOM 1961 =CA ALA- A-250 -14.469-3.315 -42-&03.1.0022.32 A

ATOM 1962 CB ALAA25G -13.716 -4.054-41.7081.0021.30 A

ATOM 1963 C ALA A 250- -15.801 -2.807-42.2341.0022.16 A ATOM 1964 O ALA A 250 -16.661 -3.622-41.882 1.0022.88 A

ATOM 1965 N HIS A 251 -16.002 -1.496-42.1491.0021.29 A

ATOM 1966 CA fflS A 251 -17.241 -0.976-41.5821.0020.38 A

ATOM 1967 CB HIS A 251 -16.922 0.130-40.588 1.0017.81 A

ATOM 1968 CG HIS A 251 -16.249 1.320-41.1991.0015.99 A ATOM 1969 CD2HISA251 -16.609 2.625-41.2391.0014.54 A

ATOM 1970 NDl HIS A 251 -15.032 1.238-41.842 1.0015.78 A

ATOM 1971 CEl fflS A 251 -14.672 2.441-42.249 1.0015.30 A

ATOM 1972 NE2HISA251 -15,610 1.300-41.895 1.0014.34 A ATOM 1973 C HIS A 251 -18.265 -0.444-42.573 1.0022.18 A

ATOM 1974 O HIS A 251 -19.306 0.084-42.1671.0023.18- A

ATOM 1975 N LEU A 252 -17.991 -0.587-43.8671.0023.49 A

ATOM 1976 CA LEU A 252 -18.893 -0.066-44.8901.0024.01 A

ATOM 1977 CB LEU A 252 -18.080 0.665-45.9441.0023.45 A ATOM 1978 CG LEU A 252 -17.175 1.707 -45.295 1.0024,28 A

ATOM 1979 CDl LEU A 252 -16.230 2.280-46.328 1.0025.33 A

ATOM 1980 CD2 LEU A 252 -18.019 2.796-44.6581.0023.14 A

ATOM 1981 C LEU A 252 -19.800 -1.083-45.5661.0023.89 A

ATOM 1982 O LEU A 252 -20.723 -0.694-46.283 1.0023.72 A ATOM 1983 N LEU A 253 -19.551 -2.373-45.3401.0023.56 A

ATOM 1984 CA LEUA 253 -20.369 -3.413-45.9671.0023.63 A

ATOM 1985 CB LEU A 253 -19.592 -4.736-46.0361.0022.61 A

ATOM 1986 CG LEU A 253 -18.524 -4.854-47.1361.0021.86 A

ATOM 1987 CDl LEU A 253 -19.040 -4.201-48.397 1.0019.44 A ATOM 1988 CD2 LEU A 253 -17.244 -4.190-46.726 1.0022.98 A

ATOM 1989 C LEU A 253 -21.744 -3.634-45.328 1.0024.62 A

ATOM 1990 O LEU A 253 -22.450 -4.594-45.655 1.0023.77 A

ATOM 1951 N GLYA-254 -22J-11 -2.73-7-44.412. LOO 25.84 A

ATOM T992 CA -GLY A 254 -23.413 -2.806-43.7571.0026.2i A ATOM £993 C GLY A 254 -23.642 -3.82Θ-42.6491.0026.43 A

ATOM 1994 O GLY A 254- -24:792 -4:077 -42.278 L-OO 26724 A

ATOM 1995 N ASFA-255^" -22.562 -4.387-42.11^1.00-25.95 A-

ATOM 1996 CA ASP A 255 -22.645 -5.378 -41.053 1.0-025.40 A

ATOM 1997 CB ASP A 255 -22.907 -6.753 -41.661 1-00-25.91 A ATOM 1998 CG ASP A 255 -22.713 -7.864-40.6671.0027.96 A

ATOM 1999 ODl ASP A 255 -21.542 -8.137-40.322 1.0027.24 A

ATOM 2000 OD2ASPA255 -23.723 -8.457-40.2241.0030.03 A

ATOM 2001 C ASP A 255 -21.344 -5.369-40.248 1.0025.58 A

ATOM 2002 O ASP A 255 -20.259 -5.402-40.8161.0026.44 A ATOM 2003 N MET A 256 -21.466 -5.320-38.925 1.0025.26 A

ATOM 2004 CA MET A 256 -20.324 -5.256-38.011 1.0024.59 A

ATOM 2005 CB MET A 256 -20.807 -5.577 -36 J 821.0024.40 A

ATOM 2006 CG MET A 256 -19.795 -5.338-35.4661.0024,15 A ATOM 2007 SD MET A 256 -19.032 -3.673-35.411 1.0028.25 A

ATOM 2008 CE MET A 256 -20.276 -2.681-34.581 1.0026.00 A

ATOM 2009 C MET A 256 -19.088 -6.100-38.363 1.0024.12 A

ATOM 2010 O MET A 256 -17.957 -5.700-38.088 1.0022.54 A

ATOM 2011 N TRP A 257 -19.288 -7.250-38.992 1.0024.84 A ATOM 2012 CA TRP A 257 -18.160 -8.110-39.332 1.0025.64 A

ATOM 2013 CB TRP A 257 -18.387 -9.506-38.7481.0026.31 A

ATOM 2014 CG TRP A 257 -18.674 -9.427-37.2861.0027.74 A

ATOM 2015 CD2TRPA257 -19.966 -9.393-36.665 1.0027.64 A

ATOM 2016 CE2 TRP A 257 -19.766 -9.124-35.2941.0028.34 A ATOM 2017 CE3 TRP A 257 -21.276 -9.555-37.138 1.0026.67 A

ATOM 2018 CDl TRP A 257 -17.765 -9.197-36.2871.0028.15 A

ATOM 2019 NEl TRP A 257 -18.415 -9.009-35.091 1.0028.29 A

ATOM 2020 CZ2 TRP A 257 -20.828 -9.011-34.391 1.0027.86 A

ATOM 2021 CZ3TRPA257 -22.324 -9.442-36.243 1.0026.13 A ATOM 2022 CH2 TRP A 257 -22.096 -9.172-34.8841.0027.49 A

ATOM^' 2023 C TRP A 257 -17.935 -8,194-40.8221.0025.79 A

ATOM 2024 O- TRP A 257 -16.976 -8.812-41.269 LOO 26.17 A

ATOM 2025 N AEA A 258- -18.826 -7:561-41.5771.0026.43 A

ATOM 2026 CA ALA A-258 -18.757 -7.544-43,033 l.θJθ_27.30 -A- ATOM 2027 CB- ALA A-258 -17.386 -7.044-43,49-1 1.0026.85 A

ATOM 2028 C ALA A 258 -4-9.000 -8.944-43.568 h00-2«ϊ20 A-

ATΘM 2029 O ALA A 258 -18.509 -9.29-7-447636170029:54 A

ATOM 2030- N GLN A 259 -19.765 -9.740-427830 1.0028,07 A

ATOM 2031 CA GLN A-259 -20.029-11.109-43.235 IJOO 28.16 A ATOM 2032 CB GLN A 259 -20.311 -11.981 -42.003 LOO 29.12 A

ATOM 2033 CG GLN A 259 -21.475-11.527-41.1261.0029.26 A

ATOM 2034 CD GLN A 259 -21.774-12.515-40.018 1.0029.00 A

ATOM 2035 OEl GLN A 259 -20.900-12.839-39.221 1.0030.26 A

ATOM 2036 NE2 GLN A 259 -23.010-13.004-39.965 1.0029.36 A ATOM 2037 C GLN A 259 -21.152-11.264-44.2571.0028.46 A ATOM 2038 O GLN A 259 -21.252-12.305-44.9081.0028.34 A

ATOM 2039 N SER A 260 -22.007-10.255-44.3871.0027.96 A ATOM 2040 CA SER A 260 -23.087-10.296-45.373 1.0028.23 A ATOM- 2041 CB SERA 260 -24.305-11.049-44.8341.0027.92 A ATOM 2042 OG SER A 260 -24.716-10.530-43.5891.0030:62 A

ATOM 2043 C SER A 260 -23.438 -8.856-45.741 1.0027.80 A

ATOM 2044 O SERA 260 -23.689 -8.023-44.864 1.0029.05 A

ATOM 2045 N TRP A 261 -23.457 -8.570-47.041 1.0026.57 A ATOM 2046 CA TRP A 261 -23.698 -7.220-47.525 1.0025.94 A ATOM 2047 CB TRP A 261 -22.712 -6.927-48.665 1.0026.22 A ATOM 2048- CG TRP A 261 -.21.312 -7.449 -48.398 1.0025.14 A ATOM 2049 CD2 TRP A 261 -20.223 -7.512-49.325 1.0024.03 A ATOM 2050 CE2 TRPA 261 -19.115 -8.053-48.632 1.0024.07 A ATOM 2051 CE3 TRP A 261 -20.072 -7.163-5.0.673 1.0023.98 A ATOM 2052 CDl TRP A 261 -20.829 -7.940 -47.2J61.0025.00 A ATOM 2053 NEl TRP A 261 -19318 -8.304 -47.347 LOO 23.79 A ATOM 2054 CZ2TRPA261 -17.868 -8.254-49.242 1.0023.28 A ATOM 2055 CZ3TRPA261 -18.834 -7.363-51.280 1.0024.44 A ATOM 2056 CH2 TRP A 261 -17.747 -7.905-50.561 1.0023.12 A

ATOM 2057 C TRP A 261 -25.117 -6.871-47.9591,0025.26 A

ATOM 2058 O TRP^~A261 -25355 -5.7υ6-48.433 1.0025.24 A

ATOM 2059 N GLU A 262 -26.057 -7.795-47.782 LOG 25.04 A ATΘKL 2060 CA GLlL-A 262 -27.453 -7.567 -48.169- 1.0024.8T A ATOM 2061 CB GLU A 262 -28.317 -8.775 -47.7771.0Θ-26.29 A ATOM 2062 CG-eaCUA-262 -27:844 -9.486-46.538 1.00.31.88 A ATOM 2063 CD GLUA 262 -28:950 -9.659-45.519 1.0036.83- A ATOM- 2064 OEl GLU A 262 -29.555 -8.630-45.1201.0039.12 A ATOM 2065 OE2GLUA.262 -29.215-10.819-45.1101.0039.09 A ATOM 2066 C GLU A 262 -28.093 -6.292-47.6301.0023.59 A

ATOM 2067 O GLU A 262 -29.167 -5.907-48.0801.0022.95 A

ATOM 2068 N ASN A 263 -27.447 -5.637-46.6701.0023.44 A ATOM 2069 CA ASN A 263 -27.990 -4.402-46.113 1.0023.32 A ATOM 2070 CB ASN A 263 -27.619 -4.245-44.6301.0024.10 A ATOM 2071 CG ASN A 263 -28.667 -4.823 -43.695 1.00 25.41 A

ATOM 2072 ODl ASN A 263 -29.834 -4.441 -43.741 1.00 25.12 A

ATOM 2073 ND2 ASN A 263 -28.254 -5.745 -42.840 1.0026.98 A

ATOM 2074 C ASN A 263 -27.528 -3.173 -46.885 1.0023.36 A ATOM 2075 O ASN A 263 -27.873 -2.061 -46.527 1.00 23.63 A

ATOM 2076 N DLE A 264 -26.729 -3.355 -47.927 1.00 23.51 A

ATOM 2077 CA ILE A 264 -26.312 -2.208 -48.717 1.00 23.66 A

ATOM 2078 CB ELE A 264 -24.767 -2.033 -48.722 1.00 21.36 A

ATOM 2079 CG2 DLE A 264 -24.289 -1.678 -47.347 1.00 19.65 A ATOM 2080 CGl BLE A 264 -24.073 -3.304 -49.180 1.0021.03 A

ATOM 2081- CDl BLE A 264- -22.579 -3.131 -49.319 1.0022.40 A

ATOM 2082 C BLE A 264 -26.855 -2.346 -50.151 1.0025.45 A

ATOM 2083 O DLE A 264 -26.478 -1.599 -51.052 1.0025.94 A

ATOM 2084 N TYR A 265 -27.767 -3.301-50327 1.0026.29 A ATOM 2085 CA TYR A 265 -28.405 -3.594 -5L607 1.0027.39 A

ATOM 2086 CB TYR A 265 -29.619 -4.492 -51.372^" LOO 26.33 A

ATOM 2087 CG TYR A 265 -30.450 -4.781 -52.602 1.0025.96 A

ATOM 2088 CDl TYR A 265 -29.920 -5.498 -53.684 1.00 26.77 A

ATOM 2089 CEl TYR A 265 -30.699 -5.778 -54.821 1.00 25.68 A ATOM 2090 CD2 TYR A 265 -31.771 -4.352 -52.685 1.0025.38 A

ATOM 2091 CE2 TYRA 265 -32.553 -4.625 -53.812 1.00 24.95 A

ATOM- 2092 CZ TYR A 265 -32.011- -5.336 -54.869 1.00 24.52 A

ATOM 2093 OH TYR A 265 -32.784 -5.603 -55.960 1.0021.97 A

ATOM 2094-C TYR A 265 -2X845 -2.341 -52156 L00-29.31 A ATOM 2095 O TYR A 265 -28.706 -2:243 -53.580 LOO 29.95 A

ATOM- 2096- N ASP A 266 -29.382 -1.381 -51.615 LOO 31.14 A

ATOM^" 2097 CA ASP A 266 -29.858 -0.140 -52JJ 0 1.00-32.38 A

ATOM 2098 CB ASP A 266 -30.668 0.669 -51.182 1.00 34.67 A

ATOM 2099 CG ASP A 266 -29.895 0.918 -49.891 1.0037.51 A ATOM 2100 ODl ASP A266 -29.605 -0.070 -49.182 1.00 39.06 A

ATOM 2101 OD2 ASP A 266 -29.570 2.092 -49.584 1.00 38.58 A

ATOM 2102 C ASP A 266 -28.730 0..717 -52.772 1.00 31.88 A

ATOM 2103 O ASP A 266 -28.990 1.704 -53.442 1.00 32.84 A

ATOM 2104 N MET A 267 -27.483 0.344 -52.507 1.00 31.37 A ATOM 2105 CA MET A 267 -26.336 1.102 -53.004 1.00 31.65 A

ATOM 2106 CB MET A 267 -25.321 1.338 -51.887 1.00 32.28 A

ATOM 2107 CG MET A 267 -25.722 2.326 -50.806 1.0033.91 A

ATOM 21-08 SD MET A 267- -24.417 2.386 -49.544 1.00 37.42 A ATOM 2109 CE MET A 267 -23.479 3.731 -50.089 1.0034.59 A

ATOM 2110 C MET^"Ai267 -25.618 0.390 -54.143 1.00 31.66 A

ATOM 2111 O MET A 267 -24.748 0.967 -54.792 1.00 31.58 A

ATOM 2112 N VAL A 268 -25.957 -0.872 -54.370 1.00 32.25 A

ATOM 2113 CA VAL A 268 -25.314 -1.633 -55.428 1.00 34.03 A ATOM 2114 CB VAL A 268- -24.474 -2.803 -54.879 1.00 33.65 A ATOM 2115 CGl- VAL A 268 -23.445 -2.2S9 -53:889 1.00 34.73 A ATOM 2116 CG2 VAL A 268 -25.38G -3.830 -54.241 1.00 33.63 A

ATOM 2117 C VAL A 268 -26.334 -2.209 -56.384 1.00 34.93 A

ATOM. 2118 O VAL A 268 -25.977 -2.654 -57.479 1.003538 A ATOM 2119^" N VAL A 269 -27.601 -2.211 -55.968 1.00-35.41 A

ATOM 2120 CA VAL A 269 -28.664 -2.746 -56.813 1.00 34.96 A

ATOM 2121 CB VAL A 269 -30.061 -2.215 -56:379 1.0034.56 A ATOM 2122 CGl VAL A 269 -30.236 -0.780 -56.791 1.00 34.65 A ATOM 2123 CG2 VAL A 269 -31.148 -3.064 -56.983 1.00 34.54 A ATOM 2124 C VAL A 269 -28.340 -2302 -58.234 J.0034.42 A

ATOM 2125 O VAL A 269 -2-8.244 -LUl -58.517 1.00 32.82 A

ATOM- 2-126 N PRO A 270 -28=113 -3266 -59.138 I JQO 35.25 A

AT-OM 2127 CD PRO A27-0 -28.156 -4.725 -58.945 1,0035.71 A

AIOM 2128 CA-PRO A-270 -27.791 =2.934 -60.530 hOQ 3.632 A ATOM^" 21:29 CB PRO AJ70 ^27.493 -4.302 -61.152 1.00 35.28 A

ATOM 2130 CG PRΘ-A 270- -28349-5228^~-60354 1.0035.54 A

ATOM- 2131 C PRO-A- 270 -28:909^~-2.171 -61,241 1.00 36.97 A

ATOM 2132 0 PRO A 27-0 -28.724 -1.021 -61.639 1.00 36.77 A

ATOM 2133 N PHE A 271 -30.070 -2.798 -61.392 1.00 37.97 A ATOM 2134 CA PHE A 271 -31.173 -2.117 -62.056 1.00 38.41 A

ATOM 2135 CB PHE A 271 -31.855 -3.056 -63.051 1.00 35.40 A

ATOM 2136 CG PHE A 271 -30.891 -3.766 -63.940 1.00 33.92 A ATOM 2137 CDl PHE A 271 -30.571 -5.104 -63.713 1.00 33.83 A ATOM 2138 CD2 PHE A 271 -30.232 -3.081 -64.955 1.00 31.74 A ATOM 2139 CEl PBE A 271 -29.605 -5.747-64.481 1.0032.50 A

ATOM 2140 CE2 PHE A 271 -29.265 -3.711-65.7241.0030.97 A

ATOM 2141 CZ PHEA271 -28.949 -5.045-65.4891.0031.01 A

ATOM 2142 C PHE A 271 -32.163 -1.611-61.0321.0039.65 A ATOM 2143 O PHE A- 271 -33.078- -2.323 -60.6251.0039.71 A

ATOM 2Ϊ44 N PRO A 272 -31,969-0.364-60:5771.0041.11 A

ATOM 2145 CD PRO A 272 -30.902 0.580-60.9461.0040.91 A

ATOM 2146 CA PRO A 272 -32.871 0.228-59.588 1.0042.37 A

ATOM 2147 CB. PRO A 272- -32.069- 1.413 -59.0701. GO 40.22 A ATOM 2148 CG PRO A 272 -31.361 1.871 -60.290 LOO 40.26 A

ATOM 2149-C PROA272 -34.123 0.65-1 -60.-330^" 1.0044.54 A

ATOM 215.0 O- PROA 272 -34.342 0.231 -61.467 LOO 46.26 A

ATOM 2151 N ALA A 273 -34.949 1.472-59.7001.0045.82 A

ATOM 2152 CA ALA A 273 -36.1-65 1.943-60.351 1.0047.58 A ATOM 2153 CB ALA A 273 -35.809 2.746-61.6071-.0046.24 A

ATOM 2154 C ALA A 273 -37.120 0.811-60,711 1.0048.33 A

ATOM 2155 O ALA A 273 -38.050 1.002-61.491 1.0048.66 A

ATOM 2156 N LYS A 274 -36.879 -0.370-60.155 1.0049.18 A

ATOM 2157 CA LYS A 274 -37.754 -1.519-60.3991.0050.03 A ATOM 2158 CB LYS A 274 -36.971 -2.665-61.0591.0047.73 A

ATOM 2159 CG LYS A274- -36:.763~ -2.459-62.5451.0046.69 A

ATOM 2160- CD LYS A 274 -36.933 -3.775 -6330J 1.0046.49- A

ATOM „216-1 CE LYS A 274 -36.594 -3.576 -64.8-43_G:0046.63 A

ATOM 2162 NZ LYfcA.274^" -37.527 -4.793-65.5720.0046.61- A- ATOM 2163 C LYS A 274^" -28:326 -1.964-59:0501.0051.79 A

ATOM 2t6ΦO LY-S A 234- -37.891 -1.475 -58τO071.00-53:02 A

ATOM- 2165 N PRO A 275 -39315. -2.874-59.0531.0053.15 A

ATOM -2166 CD PRO A 275 -39.766 -3.777-60.126 1.0054.47 A

ATOM 2167 CA PRO A 275 -39.861 -3.298-57,-7591.0054.20 A ATOM 2168 CB PRO A 275 -40.773 -4.466-58.131 1.0054.12 A

ATOM 2169 CG PRO A 275 -40.124 -5.026-59.3591.0053.83 A

ATOM 2170 C PRO A 275 -38.697 -3.702-56.8601.0055.38 A

ATOM 2171 O PRO A 275 -37.789 -4.424-57.281 1.0055.50 A

ATOM 2172 N ASN A 276 -38.836 -3.423-55.5551.0056.34 A ATOM 2173 CA ASN A 276 -37.812 -3.576 -54.509 1.00 56.65 A

ATOM 2174 CB ASN A 276 -38.078 -2.614 -53.331 1.00 56.86 A

ATOM 2175 CG ASN A 276 -37.089 -2.793 -52.113 1.00 57.47 A

ATOM 2176 ODl ASN A276 -35.894 -2.721 -52.255 1.0057.85 A ATOM 2177 ND2 ASN A 276 -37.627 -2.961 -50.934 1.00 56.05 A

ATOM 2178 C ASNA 276 -37.907 -4.897 -53.931 1.005.7.14 -A

ATOM 2179 O ASN A 276 -38.925 -5.231 -53.411 1.00 56.94 A

ATOM 2180 N LEU A 277 -36.832 -5.675 -54.010 1.00 58.1Q A

ATOM 2181 CA LEU A 277 -36.814 -7.016 -53.439 L00-59.18 A ATOM 2182 CB LEU A 277 -35.778 -T.88& -.54.151 1.0058.57 A

ATOM 2183 CG LEU A 277 -36.166 -8.408 -55.537 1.00 58.13 A

ATOM 21-84 CDl LEU AJ277 -35.064. -9.284^" -S6Λ LO 1.00 57.72 A

ATOM 2185 CD2 LEU A 277 -37.483 -9.167 -55.476 1.00 57.80 A

ATOM 2186 C LEU A 277 -36.525 -6.978 -51.941 1.0060.04 A ATOM 2F87 O LEU A 277 -35.678 -7.720 -51.444 1.0060.90 A

ATOM 2188 N ALA A 278 -37.234 -6J 09 -51.228 1.0061.14 A

ATOM 2189 CA ALA A 278 -36.741 -5573 -49.964 1.00 61.66 A

ATOM 2190 CB ALA A 278 -35.525 -6.357 -49.495 1.00 61.93 A

ATOM 2191 C ALA A 278 -37.828 -5.583 -48.894 1.0061.84 A ATOM 2192 O ALA A 278 -37.998 -4.610 -4S.160 1.00 62.55 A

ATOM 2193 N VAL A 279 -38J61 -6.688 -48r8X2 1.00 61.25 A

ATOM 2134 CA VAL A 279 -39.821 -6.720 -48.078 LOG 59:93- A

AXΘM 2195 CB .VAL A 27ft -4CL267 -8_^164 -477783 kGO 60.99 A-

ATOM 2196 -CGI VAL-A 279 -41.600 -8.172 -47Λ52 E0O-63.71 A ATOM. 2-197 GG2 VAL A 279 -40.353 -8.968 -49:072^~1.00-61.48 A

ATOM 219-8-C VAL A 279 -39.716 -5.953^~46r764 1,00 58.97 A

ATOM^" 2199 O VAL A 279 -4Θ:717 -5.472 -46.232 1^".00-58.Ol A

ATOM 2200 N THR A 280 -38.497 -5,842 -46.245 1.00 57.82 A

ATOM 2201 CA THR A 280 -38.271 -5^30 -44.947 1.00 56.13 A ATOM 2202 CB THR A 280 -36.755 -4.933 -44.775 1.00 56.62 A

ATOM 2203 OGl THR A 280 -36.509 -4.381 -43.477 1.00 56.46 A

ATOM 2204 CG2 THRA 280 -36.271 -3.968 -45.857 1.0058.61 A

ATOM 2205 C THR A 280 -39.106 -3.967 -44.663 1.00 54.28 A

ATOM 2206 O THR A 280 -39.262 -3.579 -43.508 1.00 53.27 A ATOM 2207 N SERA281 -39.658 -3.343-45.701 1.0053.32 A

ATOM 2208 CA SER A 281 -40.468 -2.133-45.513 1.0052.73 A

ATOM 2209 CB SERA 281 -40.044 -1.042-46.503 1.0052.38 A

ATOM 2210 OG SERA 281 -40.067 -1.520-47.835 1.0053.37 A ATOM 2211 C SER A 281 -41.974 -2.372-45.633 1.0051.84 A

ATOM 2212 O SER A 281 -42.777 -1.546-45.201 1.0051.21 A

ATOM 2213 N THRA282 -42.352 -3.500-46.225 1.0051.37 A

ATOM 2214 CA THR A 282 -43.762 -3.848-46.385 1.0049.74 A

ATOM 2215 CB THR A 282 -43.979 -4.756-47.6171.0049.52 A ATOM 2216 OGl THRA 2S2 -43.150 -4.305-48.6901.0049.62 A

ATOM 2217 CG2 THR A 282 -45.429 -4.712-48.0681.0048.30 A

ATOM 2218 C THRA282 -44.191 -4.605-45.1241.0049.01 A

ATOM 2219 O THRA282 -45.371 -4.639-44.761 1.0047.11 A

ATOM 2220 N MET A 283 -43.209 -5.217-44.469 1.0048.67 A ATOM 2221 CA MET A 283 -43,453 -5.962-43.248 1.0048.47 A

ATOM 2222 CB MET A 283 -42.161 -6.654-42.7821.0048.13 A

ATOM 2223 CG MET A 283 -41.786 -7.900 -43 J95 1.0046.77 A

ATOM 2224 SD MET A 283 -40.176 -8.623 -43.179 LOO 46.24 A

ATOM 2225 CE MET A 283 -40.646-10.050-42.2501.0046.37 A ATOM 2226 C MET A 283 -43.952 -4.973-42.1981.0048.36 A

ATOM 222TO MET A 283 -44.939 -5.228 -41.5081.Q048.36 A

ATOM 2228 N LEU A 284 -43.270- -3.836-42.097 LGO 48,06 A

ATOM 2229 CA LELT A 284 -43.648 -2.79-8--41.149 LO-O 47.85 A

ATOM -2230 CB LEU A 284 -42.602 -IL679 -41.13U 1.0TR5.38 A ATOM 2231 CG LEILA 284 -4L172 -2,099 -40.7971.0044τ66 A

ATQM 2232 CDl LEU A 284 -40.202: -Gr9S7 -41.1091.0043.61 A

ATOM 2233 CD2 LEU A 284 -41.098 -2.4-75 -39 J391.0044:96- A

ATOM 2234 C LEU A 284 -45.007 -2.237-41.5521.0049:52 A.

ATOM 2235 O LEU A 284 -45.898 -2.065-40.721 1.0049.98 A ATOM 2236 N GLNA285 -45.163 -1.961-42.841 1.0051.60 A

ATOM 2237 CA GLN A 285 -46.40S -1.414 -43.369 1.0052.65 A

ATOM 2238 CB GLN A 285 -46.380 -1.443-44.8941.0053.91 A

ATOM 2239 CG GLN A 285 -47.373 -0.517-45.563 1.0055.92 A

ATOM 2240 CD GLN A 285 -46.799 0.869-45.7571.0057.90 A , „

152

ATOM 2241 OEl GLN A 285 -45.664 1.015-46.221 1.0058.70 A

ATOM 2242 NE2 GLN A 285 -47.578 1.898-45.4191.0058.62 A

ATOM 2243 C GLNA285 -47.611 -2.208-42.8881.0052.55 A

ATOM 22440 GLN A 285 -48.619 -1.636-42.4891.0052.52 A ATOM 2245 N GLN A 28.6 -47.493 -3.505-42.823 1.0053.29 A

ATOM 2246 CA GLN A 286 -48.636 -4322-42.471 1.0053.87 A

ATOM 2247 CB GLN A 286 -48.564 -5.695-43.1041.0054.49 A

ATOM 2248 CG GLN A 286 -48.784 -5.715-44.5801.0056.17 A

ATOM 2249 CD GLN A 286 -48.751 -7.073-45.1741.0057.63 A ATOM 2250 OEl GLN A 286 -47.792 -7.411-45.818 1.0057.51 A

ATOM 2251 NE2 GLN A 286 -49.816 -7.860-44.983 1.0057.60 A

ATOM 2252 C GLN A 286 -48.747 -4.482-41.0061.0053.42 A

ATOM 2253 O GLN A 286 -49.698 -5.016-40.551 1.0054.29 A

ATOM 2254 N GLY A 287 -47.768 -4.01-2-40.261 1.0051.73 A ATOM 2255 CA GLY A 287 -47.767 -4.186 -3S.8161.0049,64 A

ATOM 2256 C GLY A 287 -47.3:39 -5.567-38.343 1.0047.95 A

ATOM 2257 O GLY A 287 -47.920 -6.129-37.4221.0046.72 A

ATOM 2258 N TRP A 288 -46.306 -6.113-38.9641.0047.50 A

ATOM 2259 CA TRP A 288 -45.824 -7.433-38.593 1.0047.59 A ATOM 2260 CB TRP A 288 -44.801 -7.912-39.639 1.0048.03 A

ATOM 2261 CG TRP A 288 -45.440 -8.535 -40.8701.0048.77 A

ATOM 2262 CD2. TRPA 28S -45.045 -9:749-41.528 1.0048.54 A

ATOM 2263 CE2TRPA288 -45.943 -9:959-42.596 LSΘ 48.23 A

ATOM.2264 CE3 TRP A 288 -44.019-10.680-41.3171,0047.80 A_ ATOM^" 2265 CDl TRPA 2S£ -4&530 -&Θ68 -4L558 lτθθ 48.71 A

AT©M 2266 NEl TRP A 288 -46.837 -8.921-42.593 1.0048.14 A-

ATOM 2267 CZ2TRPA288 -45.847 -11.05» -43.4471,0047.68 A

ATOM 2268 CZ3 TRP A 288 -43.926-11.772-42.1671.0046.79 A

ATOM 2269 CH2 TRP A 288 -44,835-11.951-43.216 1.0046.87 A ATOM 2270 C TRP A 288 -45.259 -7.585-37.162 1.0047.03 A

ATOM 2271 O TRP A 288 -44.282 -6.950-36.7671.0045.80 A

ATOM 2272 N ASN A 289 -45.913 -8.455-36.405 1.0047.78 A

ATOM 2273 CA ASN A 289 -45.565 -8.797-35.028 1.0047.54 A

ATOM 2274 CB ASN A 289 -46.684 -9.689-34.469 1.0047.90 A ATOM 2275 CG ASN A 289 -47.121 -9.303-33.0801.0049.23 A

ATOM 2276 ODl ASN A 289 -47.347 -8.129-32.7861.0049.13 A

ATOM 2277 ND2 ASN A 289 -47.276-10.304-32.2141.0051.71 A

ATOM 2278 C ASNAJ289 -44.264 -9.600-35.091 1.0047.29 A ATOM 22790 ASN A 289 -43.860-10.047-36.161 1.0047.17 A

ATOM 2280 Η ALA A 290 -43.601 -9.787-33.9591.0047.24 A

ATOM 2281 CA ALA A 290 -42.393-10.594-33.977 1.0047.47 A

ATOM 2282 CB ALA A 290 -41.562-10.334-32.732 1.0047.04 A

ATOM 2283 C ALA A 290 -42.892 -12.038^" -34.0041.0047.73 A ATOM 2284 O ALA A 290 -42.207 -12.949 -34 ,454 1.0047.18 A

ATOM 2285 N THRA291 -44.111-12.230-33.5171.0049.29 A

ATOM 2286 CA THR-A 291 -44.720-13-554-33.485 1.0050.78 A

ATOM 2287 CB THR A 291 -45.945-13.594-32.535 1.0050.18 A

ATOM 2288 OGl THR A 291- -45.535-13.266-31.2051.0048.53 A ATOM 2289 CG2 THR A 291 -46.568-14.975-32.5241.0049.17 A

ATOM 2290 C THRA291 -45.188-13.882-34.895 1.0051.55 A

ATOM 2291 O THR A 291 -44,998-14.997-35.3871.0050.92 A

ATOM 2292 N HIS A 292 -45.802-12.895-35.538 1.0052.39 A

ATOM 2293 CA HIS A 292 -46:295-13.049-36.8991.0053.14 A ATOM 2294 CB HIS A 292 -46.678-11.675-37.4671.0056.29 A

ATOM 2295 CG HIS A 292 -47.468-11.737-38.741 1.0060.35 A

ATOM 2296. CD2 HEES-- A 292 -48:221 -10.803 -39.375- 1.006-1.48 A

ATOM 2297 NDl HIS A 292 -47.542-12.878-39.515 1.00.62.05 A

ATOM 2298- CEl HIS A.292 -„48:303 -12.645 -40.571 1.0062.15 A ATOM 2299 NE2 HIS A 292 -48.728 -11.393- -40.509 LOO 62,89- A

ATOM 2300 C HIS.A-292 -45.202 -13.696 -37.753 1.0052.03 A

ATOM 2301 O HIS A 292 -45.479-14:502-38.6401.0052.05 A

ATOM 2102 N MET A 293 -43.955-13.342-37.4701.0050.45 A

ATOM 2303 CA MET A 293 -42.829-13.889-38.208 1.0048,16 A ATOM 23.04 CB MET A 293 -41.552-13.108-37.8841.0048.42 A

ATOM 2305 CG MET A 293 -41.447-11.790-38.646 1.0048.32 A

ATOM 2306 SD MET A 293 -40.158-10.699-38.0341.0048.72 A

ATOM 2307 CE MET A 293 -38.711-11.698-38.3541.0048.96 A

ATOM 2308 C MET A 293 -42.635-15.366-37.9291.0046.73 A , ,₄

154

ATOM 2309 O META293 -42.374-16.136-38.845 1.0047.63 A

ATOM 2310 N PHEA294 -42.773-15.777-36.6761.0045.17 A

ATOM 2311 CA PHE A 294 -42.603-17.189-36.351 1.0043.68 A

ATOM 2312 CB PHE A 294 -42J52 -17.374 -34.8521.0040.35 A ATOM 2313 CG PHE A 294 -40.981 -16.956 -34.4171.0036.79 A

ATOM J2314 CDl PHE A 294 -40.661-15.615-34.2741.0035.06 A

ATOM 2315 CD2PHEA294 -39.997-17.908-34.185 1.0035.75 A

ATOM 2316 CEl PHE A 294 -39.387-15.231-33.9071.0033.22 A

ATOM 2317 CE2 PHE A 294 -38.721-17.533-33.8201.0034.26 A ATOM 2318 CZ PHE A 294 -38.416-16.192-33.6801.0033.79 A

ATOM -2319 C PHE A 294 -43.786-18.046-36.801 1.0044.38 A

ATOM 2320- O PHE A 294 -43.745-19.272-36.7121.0044.86 A

ATOM 2321 N ARG A 295 -44.760-17.442-37.422 1.0045.00 A

ATOM 2322 CA ARG A 295 -45.944 -18.153 -37.833 1.00- 46.23 A AT-OMT 2323 CB ARG A 295 -47.163 -17.338 -37.4991.0048.19 A

ATOM 2324 CG ARG A 295 -47.787-17.628-36.2181.0050.42 A

ATOM 2325 CD ARG A 295 -49.122-17.065-36.1261.0052.42 A

ATOM 2326 NE ARG A 295 -49.561-16.478-37.371 1.0054.53 A

ATOM 2327 CZ ARG A 295 -50.660 -16.8 B -38.0061.005-5.99 A ATOM 2328 NHl ARG A 295 -51.439-17.739-37.5371.0055.63 A

ATOM 2329 NH2 ARG A295 -50.985 -16.231 -39.1261^".OO 56.81 A

ATOM- .2330 C ARG A 295 -45.995 -L8.3-87 -39.2871.004X96 A

ATOM 2331- O ARG A 295 -46.49S-19.376 -39.733 1.0045.98 A

ATOM 2332 N V&LA296 -45.529 -1-7.4OS -"40.0341.00453.9 A ATOM^" 2333 CA VAL A 296 -45.275-17.532-41:4591.0044.03. A

ATOM 2334- CB-VAL A 296 -44Λ18 -16.182^" -42.0441:9043.10 A

ATOM 2335 CGl VAL A 296 -44.973-16.179-43.-556 LOO 42.43 A-

ATOM 2336 CG2 VAL A 296 -45.626 -15.Θ6-1 -41.4291.0042.76 A

ATOM 2337 C VAL A 296 -44.190-18.576-41.695 1.0043.78 A ATOM 2338 O VAL A 296 -44.310-19.430-42.570 1.0044.52 A

ATOM 2339 N ALA A 297 -43.126-18.504-40.908 1.0042.69 A

ATOM 2340 CA ALA A 297 -42.042-19.457-41.0401.0043.01 A

ATOM 2341 CB ALA A 297 -40.955-19.147-40.0471.0041.85 A

ATOM 2342 C ALA A 297 -42.578-20.853-40.7971.0044.05 A ATOM 2343 O ALA A 297 -42.228-21.791-41.5071.0044.98 A

ATOM 2344 N GLU A 298 -43.430-20.988-39.7871.0044.72 A

ATOM 2345 CA GLU A 298 -44.012-22.281-39.453 1.0044.68 A

ATOM 2346 CB. GLU A 298 -44.837-22.177-38.163^" 1.0045.17 A ATOM 234-7 CG GLU A 298 -43.570-23.459-37.7681.0045.21 A

ATOM 2348 CD GLU A 298 -46.475 -23.277 -36τ548 1.0045.68 A

ATOM 2349 OEl GLU A 298 -47.214-22.273-36.5051.0046.03 A

ATOM 2350 OE2 GLU A 298 -46.460-24.141-35.641 1.0045.61 A

ATOM 2351 C GLU A 298^' -44.S96 -22.745 -40.598 1.0044.42 A ATOM 2352 O GLU A 298 -44.772-23.870-41.071 1.0042.67 A

ATOM 2353 N GLU A 299- -45.844-21.951-40.9941.0045.21 A

ATOM- 2354 CA GLU A 299 -46.650-22.294-42.1171.0047.08 A

ATOM 2355 CB GLU A 299 -47.336-21.086-42.6121.0047.94 A

ATOM 2356- CG GLU A 299 -48.581-21.413-43.325 1.0051.36 A ATOM 2357 CD GLU A 299 -48.657-20.698-44.593 1.0053.85 A

ATOM 2358 OEl GLU A 299 -49.464-21.114-45.4071.0055.0.1 A

ATOM 2359 OE2 GLU A 299 -47.894-19.746-44.7671.0055.05 A

ATOM 2360 C GLU A 299 -45.950-22.950-43.2741.0047.09 A

ATOM 2361 O GLU A 299 -46.414-23.897-43.8141.0047.43 A ATOM 2362 N PHE A 300 -44.830-22.446-43.683 1.0045.66 A

ATOM .2363. CA IΗE A 300 -44.119 --23,088 -44.786 1.0043.98 A

ATOM 2364-CB^~-£HEA300 -42.782-22.379-45.063 1.0043.64 A

ATOM 2365 -CG EHE A 300- -42.061-22.8-79-46.303 1.0043.14 A

ATOM- 2366 CDl PHE A 300 -42.093 -22.148-47.4901.0042.21 A ATOM 2367 CD2 PHE A 300 -41355-24.0.83 -46.2851.0043.25 A

ATOM 2168 CEl PHE A 300 -41.43-8-22.608 -48τ6291:004 LΘ2 A

ATOM 2369- CE-LPHE A 300 -40=696-24.549-47.4271.0041.50 A

ATOM 2370 CZ PHE A 300 -40.739-23.813-48.5941.0041.03 A

ATOM 2371 C PHE A 300 -43,850-24.524-44.3361.0043.56 A ATOM ^'2372 O PHE A 300 -44.262-25.476-44.9891.0044.47 A

ATOM 2373 N PHE A 301 -43.172-24.660-43.1991.0042.19 A

ATOM 2374. CA PHE A 301 -42.825-25.965-42.6451.0040.18 A

ATOM 2375 CB PHE A 301 -42.283-25.814-41.2191.0037.78 A

ATOM 2376 CG PHE A 301 -40.811-25.523-41.146 1.0034.84 A , _s

ATOM 2377 CDl PBDE A 301 -40.337-24.223-41.2461.0034.08 A

ATOM 2378 CD2PHEA301 -39.895-26.558-40.971 1.0033.67 A

ATOM 2379 CEl PHE A 301 -38.971-23.959-41.171 1.0033.29 A

ATOM 2380 CE2PHEA301 -38.527-26.301-40.8971.0032T70 A ATOM 2381 CZ PHFA 301 -38.Θ6S -25.0OJO -40.9961.0032.07 A

ATOM 2382 C PHE A 301 -43.96! -26.982 -42.6221.0039:60 A

ATOM 2383 O PHE A 301 -43.761-28.160-42.9251.0038.51 A

ATOM 2384 N THRA 302 -45.152-26.539-42.2441.0039.59 A

ATOM 2385 CA THR A 302 -46.274 -27.459 -42.172^'1.0041.02 A ATOM 2386 CR THR A 302 -47.509-26.800-41.4791.0039.84 A

ATOM 2387 OGl THR A 302 -47.864-25.589-42.155 1.0039:60 A

ATOM 2388 CG2 THRA 302 -47203-26.483-40.028 1.0039.29 A

ATOM 2389 C THR A 302 -46.663-27.988-43.563 1.0042.86 A

ATOM 2390 O THRA 302 -46.840-29.203-43.7601.0042.70 A ATOM 239-1 N SER A 303 -46,768-27.081-44.531 1.00-43.58 A

ATOM 2392 CA SER A 303 -47.149-27.452-45.8901.0O44.01 A

ATOM 2393 CB SER A 303 -47.096-26.225-46.8091.0044.17 A

ATOM 2394 OG SER A 303 -45.763-25.830-47.0791.0044.37 A

ATOM 2395 C SER A 303 -46.296-28.574-46.4841.0044.52 A ATOM 2396 O SER A 303 -46.769-29,326-473391.0045.65 A

ATOM 2397 N LEU A 304 -4§3)50 -28.696 -46,0381.0044.20 A

ATOM 2198 CA- LRU A 304 -44.174-29.736-46.558 1.0043.61 A

AT-ΘM 2399.CB JJEU A 304 -42.709-2-9.325. -46.441 1.0044 Λ3. A

ATOM 2400 GG LEU A 304 -42.283-27:946-46.931 1:0044.53 A ATOM 2401- CDlLEUA 304 ~40.7S6^~~27;S92 -46.955 1.00:45,82 A

ATOM 2402 CD2 LEU A 304- -42.858-27.674 -48.309 1.00- 44-:97 A

ATOM 2403 C LEU A 304 -44.386-31.021 -45.79-1 1.0043.1-6 A

ATOM 2404 O LEU A 30.4 -43.546-31.911-45.833 1.0043.58 A

ATOM 2405 N ALAA3Q5 -45.509-31.108-45.0861.0043,29 A ATOM 2406 CA ALA A 305 -45.846-32.293-44.2971.0044.68 A

ATOM 2407 CB ALA A 305 -46.010-33.526-45.2181.0045.41 A

ATOM 2408 C ALA A 305 -44.826-32.580-43.1841.0044.56 A

ATOM 2409 O ALA A 305 -44.503-33.741-42.8921.0043.53 A

ATOM 2410 N LEUA 306 -44.317-31.505-42.5841.0045.06 A ATOM 2411 CA LEU A 306 -43.373-31.581-41.4701.0045.51 A

ATOM 2412 CB LEUA 306 -42.164-30.679-41.729 1.0045.35 A

ATOM 2413 CG LEU A 306 -41.140-31.202-42.7371.0044.52 A

ATOM 2414 CDl LEU A 306 -40.056-30.165-42.9371.0044.63 A ATOM 2415 CD2LEUA306 -40.535 -32 J504 -42.241 1.0043:49 A

ATOM 2416 C LEU A 306 -44.152-31.106-40.2291.0046.15 A

ATOM 24170 LEU A 306 -45.150-30.389-40.366 1.0046.08 A

ATOM 2418 N SER A 307 -43.716-31.496-39.031 1.0046.01 A

ATOM 2419 CA SER A 307 -44.443-31.108-37.8141.0045.51 A ATOM 2420 CB SER A 307 -43.982-31.942-36.6141.0043.93 A

ATOM 2421 OG SER A 307 -42.579-31.-999-36.543 1.0044.26- A

ATOM 2422 C SER A 307 -44.357-29.628-37.487 i.0045,08 A

ATOM 2423 O SER A 307 -43.357-28.983-37.7971.0046.29 A

ATOM 2424 N PRO A 308 -45.426 -29.066 -36.873 1.0045.91 A ATOM 2425 CD PRO A 308 -46.707-29.743-36.585 1.0045.44 A

ATOM 2426 CA PRO A 308 -45.503-27.650-36.490 1.0045.32 A

ATOM 2427 CB PRO A 308 -47.003-27.387-36.4581.0044.65 A

ATOM 2428 CG PRO A 308 -47.519-28.655-35.8781.0045.01 A

ATOM 2429 C PRO A 308 -44.860-27.439-35.1291.0045.03 A ATOM 2430 O PRO A 308 -44.426-28.396-34.4851.0044.68 A

ATOM 2431 N MET A 309 -44.796 -26J 94 -34.6871.00453)7 A

ATOM 2432 CA MET A 309 -44.18S -25.917 -33.399 1.0046.33 A

ATOM 2433 -CB MET A 309 -43.944 -24.4Lt-33.245 1.0047.46 A

ATOM 2434 CG MET A309 -42.849-237876-34.154 L00-48 ,16 A -ATOM 2435-SD META 309 -41.287~24.765^~-33.963 LOO 49:70 ^" A-

ATOM 2436 CE MET A3Θ9 -41.229-25.740-35=483170048.35 A

ATOM 2437 C META 309- -45.083 -26.42S -32.2781.0046.90 A

ATOM 24380 MET A 309 -46.283-26.129-32.2491.0047.22 A

ATOM 2439 N PROA310 -44.513-27.214-31.3431.0046.78 A ATOM 2440 CD PRO A 310 -43.105-27.626-31.2581.0046.29 A

ATOM 2441 CA PRO A 310 -45.269-27.767-30.2161.0046.85 A

ATOM 2442 CB PRO A 310- -44.238-28.619-29.482 1.0045.99 A

ATOM 2443 CG PRO A 310 -43.226-28.923-30.512 1.0046.44 A

ATOM 2444 C PRO A 310 -45.778-26.631-29.3361.0047.87 A ATOM 2445 O PROA 310 -45.324-25.487-29.4551.0048.50 A

ATOM 2446 N PROA 311 -46.749-26.917-28.4601.0047.98 A

ATOM 2447 CD PROA 311 -47.712-28.033-28.4821.0047.84 A

ATOM 2448 CA PRO A 311 -47.229 -25.825 -27.608 LOO 47.56 A

5 ATOM 2449 CB PRO A 311 -48.452-26.433-26.933 1.00-47.83 A

ATOM 2450 CG PRO A 3Tl -48.984-27.361-28.001 1.0047.61 A

ATOM 2451 C PRO A 311 -46.140-25.380-26.6121.0047.35 A

ATOM 2452 O PRO A 311 -46.028-24.191-26.2981.0047.68 A

ATOM 2453 N GLU A3 Yl -45.332-26.327-26.1301.0045.60 A

10 ATOM 2454 CA GLU A 312 -44.255-26.006-25.1921.0045.03 A

ATOM 2455 CB GLUA 312 -43.391-27.237-24.889 hθO 46.14 A

ATOM 2456 CG GLU A 312 ^• -44.110 -28.378 -24.1"841.0048.91 A

ATOM 2457 CD GLU A 312 -44.872-29.279-25.1441.0051.53 A

ATOM 2458 OEl GLU A 312 -45.686-28.761-25.943 1.0052.09 A

15 ATOM 2459 OE2GLUA312 -44.659 -30.511- -25.098 1.0052.72 A

ATOM 2460 C GLUA 312 -43.368-24.915-25.778 1.0044.55 A

ATOM 2461 O GLUA312 -42.958-23.995-25.071 1.0043.54 A

ATOM 2462 N PHE A 313 -43.076-25.034-27.0741.0044.47 A

ATOM 2463 CA PHE A 313 -42.236-24.074-27.7941.0043.27 A

20 ATOM 2464 CB PHE A 313 -42.063-24.498-29.261 1.0041.88 A

ATOM 2465 CG PHE A 313 -41.521-23.404-30.1601.0040.31 A-

ATOM 2466 CDl PHE A 313 -40,156 -23.192 -3Θ.2841.0035.59 A

ATOM 2467 CD2 PHE A 313 -42.388-.22.581 -30.879 Lββ 39.9-7 A

ATOM 2468 CEl PHE A313 -39τ664 -22.179 -31.109 ^" h0037=54 A

25. ATOM 2469-CE2PHEA313 -41.903 -2L565 -3-1.704- 1.0038.36 A

ATOM 2470 CZ PHEA 313 -40.540 -21.366 -3b819 I^'M 37.59 A

ATOM 2471 C PHE A 313 -42.850 -22.688^{^}-27.7551.0043.49 A

ATOM 2472 O PHE A 313 -42.147 -21.693 -27.5891.0043.91 A

ATOM 2473 N TRP A 314 -44.162 -22.617 -27.916.1.0043.61 A

30 ATOM 2474 CA TRPA 314 -44.814-21.327-27.9101.0045.36 A

ATOM 2475 CB TRP A 314 -46.198-21.427-28.541 1.0047.01 A

ATOM 2476 CG TRP A 314 -46.154-21.566-30.023 1.0048.38 A

ATOM 2477 CD2 TRP A 314 -45.872-20.531-30.9671.0049.14 A

ATOM 2478 CE2 TRPA 314 -45.959-21.104-32.255 1.0049.83 A , «

159

ATOM 2479 CE3 TRP A 314 -45.556-19.172-30.851 1.0049.92 A

ATOM 2480 CDl TRP A 314 -46.386-22.695-30.749 1.0049.75 A

ATOM 2481 NEl TRP A 314 -46.273-22.427-32.093 1.0050.05 A

ATOM 2482 CZ2 TRP A 314 -45.742-20.368-33.421 1.0050.47 A ATOM 2483 CZ3 TRP A 314 -45.340,-18.439-32.0101.0050.46 A

ATOM 2484 CH2 TRP A 314 -45.436-19.043-33.281 1.0050.94 A

ATOM 2485 C TRPA 314 -44.919-20.723-26.5291.0045.57 A

ATOM 24860 TRPA314 -44.947-19.511-26.392 1.0045.84 A

ATOM 2487 N ALA A 315 -44.971-21.558-25.501 1.0046.64 A ATOM 2488 CA ALA A 315 -45.078-21.046-24.142 1.0046.92 A

ATOM 2489 CB ALA A 31-5 -45.768-22.072-23.241 1.-0046.47 A.

ATOM 2490 C ALAA 315. -43.700-20.713-23.592 1.00-47.83 A

ATOM 2491 O ALA A 315 -43.514-19.684-22.9341.0048.24 A

ATOM 2492 N GLYA 316 -42.730 -21.573 -23.887 LOO 48.69 A ATOM 2493 CA GLYA 316 -41.386 -21.372 -23.374 1.0050-.26 A

ATOM 2494 C GLYA 316 -40.348-20.620-24.1921.0050.83 A

ATOM 2495 O GLYA 316 -39.219-20.452-23.7291.00-52.01 A

ATOM 2496 N- SERA 317 -40.695-20.153-25.3861.0050.48 A

ATOM 2497 CA SER A 317 -39.712-19:440 -26.203 1.0050.05 A ATOM 2498 CB SERA 317 -39.959-19.687-27.6961.0049.41 A

ATOM 2499 OG SERA 317 -39.559 -20.992 -28.0S1 1.0050.33 A

ATOM 2500 C SER A 317 -39.701-17.950-25.954 1.0049.75 A

ATOM 2501 O SERA 317 -40.701-17.378-25.5261.0051.07 A

ATOM 2502 N JdEETA 318 -38.558-17.329-26.2191-.004S.28 A- ATOM 2503 CA MET A 318 -38.413 -±5.889-26.0671.00:4.6.77 A

ATOM 2504 €B META 3-U -37.232 -15;553 -25.166.1.0047.20 A

ATOM 2505 GG META 318 -37.151-14.083 -24;8201.0048.61 A

ATOM 2506 SD META 318 -35.537-13.650-24.189 1.0051.05 A

ATOM 2507 CE MET A 318 -34.589-13.681-25.7021.0050.70 A ATOM 2508 C META 318 -38.159-15.369-27.4701.0045.29 A

ATOM 2509 O META 318 -37.072-15.536-28.013 1.0045.05 A

ATOM 2510 N LEUA319 -39.160-14.736-28.0581.0043.87 A

ATOM 2511 CA LEUA 319 -39.020-14.260-29.4161.0043.93 A

ATOM 2512 CB LEUA 319 -40.201-14.768-30.2391.0042.93 A , _fin

ATOM 2513 CG LEU A 319 -40.633-16.205-29.939 1.0041.40 A

ATOM 2514 CDl LEU A 319 -41.803-16.570-30.825 1.0041.02 A

ATOM 2515 CD2LEUA319 -39.476-17.158-30.155 1.0041.65 A

ATOM 2516 C LEU A 319 -38.920-12.748-29.5341.0045.15 A

5 ATOM 25170 LEUA 319 -39.087 -12J.92 -30.623 1.0046.47 A

ATOM 2518 N GLU A 320 -38.651-12.082-28.418 1.0045.25 A

ATOM 2519 CA GLU A 320 -38.527-10.629-28.402 1.0045.68 A

ATOM 2520 CB GLU A 320 -39.890 -9.973-28.1881.0045.43 A

ATOM 2521 CG GLU A 320 -40.809-10.022 -29.3991.O048.16 A

10 ATOM 2522 CD GLU A 320 -42.225 -9.535-29.0961.0049.53 A

ATOM 2523 OEl GLU-A 320 -42.903-10:185-2.8.2741.0050.45 A

ATOM 2524- OE2 GLU A 320. -42.665 -8.511-29.673 1.0049.57 A

ATOM 2525 C GLU A 320 -37.607-10.229-27.2741.0046.46 A

ATOM 2526 O GLU A 320 -37.471-10.955-26.2991.0047.25 A

15 ATOM 2527 N LYS A 321 -36.963 -9.079 -27.4081.0047.42 A

ATOM 2528 CA LYS A 321 -36.079 -8.603 -26.3601.0048.46 A

ATOM 2529 CB LYS A 321 -35.230 -7.439-26.8681.0047.61 A

ATOM 2530 CG LYS A 321 -34.024-7.124-26.0041.0047.19 A

ATOM 2531 CD LYS A 321 -33.313 -5.870-26.4741.0046.34 A

20 ATOM 2532 CE LYS A 321 -32.160 -5.518-25.553 1.0046.22 A

ATOM 2533 NZ LYS A 321 -31.593 -4.177-25.879 ITOO 46.44 A

ATOM 2534 C LYSA321 -37.027 -8.128" -25.268 1.0049.93 A

-ATOM 2535 O LYSA 321 -37.778 -7.176-25.465 1.0050.39 A

ATΘM.2536 N PRO -A- 322^" -36.986 -8.795_-24U 19 1.0051.31 A

-25- ATOM^' 2537 CD PRO A 322 -36.159 -9.984.-23.846 1.0052.43 A-

ATOM 2538-CA PRO A-322 -37.932 -3:519-23-033 1.0052725 A

ATOM^ 2539 CB PRO A322 -37.472 -9r466 -21.925- 1.0053.08 A

ATOM 254G CG PRO A 322 -36.824-10.594-22.6461.00.52.-83 A

ATOM 2541 C PRO A 322 -37.839 -7.072-22^571.0053.49 A

30 ATOM 2542 O PRO A 322 -37.014 -6.310-23.059 1.0053.08 A

ATOM 2543 N ALA A 323 -38.682 -6.705-21.596 1.0055.17 A

ATOM 2544 CA ALA A 323 -38.864 -5.306-21.231 1.0056.32 A

ATOM 2545 CB ALA A 323 -40.206 -4.797-21.7391.0055.48 A

ATOM 2546 C ALA A 323 -38.756 -5.111-19.7221.0057.50 A _Λ,_Λ

161

ATOM 25470 ALA A 323 -38.791 -3.984-19.2291.0058.43 A

ATOM 2548 N ALA A 324 -38.624 -6.216-18.995 1.0058.32 A

ATOM 2549 CA ALA A 324 -38367 -6.163-17.561 1.0058.25 A

ATOM 2550 CB ALA A 324 -38.533 -7.542-16.9421.0057.56 A ATOM^ 2551 C ALA A 324 -36.975 -5.612-17.271 1.0058.53 A

ATOM 2552 O ALA A 324 -36.475 -5.720-16.151 1.0058.53 A

ATOM 2553 N GLY A 325 -36.354 -5.020-18.2861.0058.98 A

ATOM 2554 CA GLY A 325 -34.995 -4.527-18.1661.0058.88 A

ATOM 2555 C GLY A 325 -33.974^' -5.646-18.119 1.0058.25 A ATOM 2556 O GLY A 325 -32.772 -5.409-18.240 1.0058.50 A

ATOM 2557 N- AKG A 326 -34.455 -6.873 -17.943 1.0056.31 A

ATOM 2558- CA ARG A 326 -33.588 -8.045-17.954 1.0055.26 A

ATOM 2559 CB ARG A 326 -34.412 -9.320-18.144 1.0055.27 A

ATOM 2560 CG ARG A 326 -35.821 -9.238-17.580 1.0.055.77 A ATOM -2561 CD ARG A 326 -36.344-10.552-17.0231.0055.61 A

ATOM 2562 NE- ARGA 3J26 -35.988-11.686 -17.8701.0054.23 A

ATOM 2563 CZ ARG A 32tf -36.667-12.053-18.9491.0054.37 A

ATOM 2564 NHl ARGA 326 -37.745-11.376-19.318 1.0054.32 A

ATOM 2565 NH2 ARG A 326 -36.269-13.099-19.661 1.0053.97 A ATOM 2566 C ARG A 326 -32.528 -7.938 -19.0461.0055.56 A

ATOM 25(57 O ARG A 3-26 -32.815 -7.519-20.1661.0056.77 A

ATOM 2568^" N GLUA 327 -31.325 -8.354-18,746..1.0054-37 A

ATOM 2569 CA GLIJ-A 327 -30.265 -8.346 -19.6921.0052.58 A

ATOM 2570 -CB GLU A 327 -JS:0U -7.959-18.950^ LOO-5330 A ^" ATOM 2571 CG GLU A 327 -27.884 -7.486-19.8041.0055773^" A

ATOM 2572 CD- GLU A 327 -27.298 -6.^"217-19.3OO 1.0056.88 A

ATOM 2573 OEl GLU A 327 -27.T47 -6.091 -18.088 1.0057.95 A

ATOM 2574 OE2 GLU A 327 -27.000 -5.359 -2Q.113 1.0057.03 A

ATOM 2575 C GLU A 327 -30.103 -9.706-20.2801.00-50.91 A - ATOM 2576 O GLU A 327 -29.875-10.634-19.573 1.0049.89 A

ATOM 2577 N VAL A 328 -30.197 -9.814-21.6021.0048.95 A

ATOM 2578 CA VAL A 328 -30.160-11.111-22.2821.0046.42 A

ATOM 2579 CB VAL A 328 -31.546-11.467-22.851 1.0044.97 A

ATOM 2580 CGl VAL A 328 -32.573-11.469-21.7471.0045.10 A ATOM 2581 CG2 VAL A 328 -31.941-10.471-23.928 1.0044.05 A

ATOM 2582 C VAL A 328 -29.172-11.267-23.4321.0045.65 A

ATOM 2583 O VAL A 328 -28.794-10.301-24.0871.0046.39 A

ATOM 2584 N VAL A 329 -28.768-12.512-23.6671.0044.93 A ATOM^" 2585 CA VAL A 329 -27.862-12.842-24.758 1.0043.67 A

ATOM^" 2586 CB VAL A 329 -27.294-14.261-24.611 1.0042.47 A

ATOM 2587 CGl VAL A 329 -26.215-14.493-25.643 1.0041.51 A

ATOM 2588 CG2 VAL A 329 -26.752-14.462-23.2141.0041.53 A

ATOM 2589 C VAL A 329 -28-.766 =12.801 -25.982 1.0043.98 A ATOM 2590 O VAL A 329 -29.410-13.792-26.3251.0042.84 A

ATOM 2591 N CYSA 330 -28.822 ~41.641 -2S.628 h0044.30 A

ATOM.2592 CA-CYS A 330 -29.678-11.444-27:7841.0044.94 A

ATOM 2593 C CYS A 330 -29.435-12.296-29.0221.0044.95 A

ATOM 2594 O CYS A 330 -30.324 -12.421 -29.871 1.0045.34 A - ATOM 2595 CB CYS A 330 -29.668 -9:974-28.1861.0045.77 A

ATOM 2596 SG CYS A 330 -30.970 -8.984-27.3791.0051.29 A

ATOM 2597 N HIS A 331 -28.252-12.886-29.1421.0044.35 A

ATOM 2598 CA HIS A 331 -27.970-13.703-30.315 1.0043.52 A

ATOM 2599 CB HIS A 331 -26.609-14.368-30.1801.0044.40 A ATOM 2600 CG HIS A 331 -25.948-14.665-31.491 1.0046.22, A

ATOM 2601 CD2ΗISA331- -25.537 -15:833 -32:040 1.0047.00 A

ATOM 2602 NDl HIS A53Y -25.603-13.676-32.3891.0047.55 A

AXOM 2603 CEl HϊS-A-331 -25.004 -14.220 -33τ431 1.0048.36 A

ATOM 2604 NE2.fflSAt531 -24.952 -15.528 -33.2461.00=48:19 A - ATOM 2605 C HIS A- 33-1- -29:042 -14.76S^~3Q.473 1.0042:85 A

ATOM 2606 O HIS-A-33-1 -29.392 -15.449-29^"τ5141:0043.53- A^{^}

ATOM 2607 N ALA A 332 -29.569-14.904-31.681 ITOO 41^".4T^" A

ATOM 2608 CA ALA A 332 -30.593 -15.898 -3fc9551.0039.57 A

ATOM 2609 CB ALA A 332 -31J70 -15.678 -33.339 1.0039.70 A ATOM 2610 C ALA A 332 -29.989 -17.295 -31.860 LOO 38.69 A

ATOM 2611 O ALA A 332 -28.869-17.522-32.3161.0037.97 A

ATOM 2612 N SER A 333 -30.733-18.223-31.2591.0038.48 A

ATOM 2613 CA SERA 333 -30.287-19.608-31.111 1.0038.16 A

ATOM 2614 CB SER A 333 -29.315-19.729-29.943 1.0038.29 A ATOM 2615 OG SERA 333 -29.890-19.203-28.765 1.0039.09 A

ATOM 2616 C SER A 333 -31.479-20.537-30.8901.0037.81 A

ATOM 2617 O SERA 333 -32.588-20.079-30.6001.0036.94 A

ATOM 2618 N ALAA334 -31.245-21.840-31.0391.0037.25 A ATOM 2619 CA ALA A 334 -32.293 -22.843--30357 LOO 37.13 A

ATOM 2620 CB ALA A 334 -32.559-23.552-32.165 1.0037/00 A

ATOM 2621 C ALA A 334 -31.895-23.846-29.771 1.0037.29 A

ATOM 2622 O ALA A 334 -30.770-24.339-29.7421.0037.22 A

ATOM 2623 N TRP A 335 -32.839 -24.159 -28J921.003-7.54 A ATOM 2624 CA TRP A 335 -32.578-25-048-27.768 1.0037.20 A

ATOM 2625 CB TRP A 335 -32.927-24.312-26.4741.0036.46 A

ATOM 2626 CG TRP A 335 -32.198 -23.011 -26.3371.0036.46 A

ATOM 2627 CD2TRPA335 -31.272-22.654-25.3091.0036.03 A

ATOM 2628 CE2 TRP A 335 -30.803 -21.351 -25.601- JJ)O 36.00 A ATOMT 2629 CE3 TRP A 335 -30.791-23.308-24.1691.0035.il A

ATOM 2630 CDl TRP A 335 -32.256-21.937-27.189 1.0036.40 A-

ATOM 2631 NEl TRP A 335 -31.419-20.940 -26.754 LOO 35.90 A

ATOM 2632 CZ2 TRP A 335 -29.876-20.693-24.7951.0035.28 A

ATOM 2633 CZ3 TRP A 335 -29.873-22.655-23.371 1.0035.70 A ATOM 2634 CH2 TRP A 335 -29.423-21.357-23.6861.0035.28 A

ATOM 2635 C TRP A 315 -33.249 -26.41-3 Ϊ27.765 1.0CL36.99 A-

ATOM 2636 O TRPA^" 335- -34.454 -26.535 -27.9751:0036.86 A

ATOM 2637 N ASPA-336 -32.444-27.435-27:502- 1.00.37.04 A

ATOM 263$; CA "ASP A 336 -32.916 -28 J^8--27.42S- 1.0037.26 A ATOM- 2639 CB ASP A-336 -32:114 -29.685 -28-7395 -£0037.58 A-

ATOM- 2640^CG ASP A-336 -32,640 -31.109 -28.484- 1.0036.98 A

ATOM 2641 ODl ASP A 33^- -33.83« -3-1.323-28:194 LM36.6-1 A

ATOM 2642 OD2 ASP A 336 -31.855-32.007-28.8691.0035.00 A

ATOM 2643 C ASP A 336 -32.677-29.239-25.9841.0037.95 A ATOM 2644 O ASP A 336 -31.526-29.379-25.5581.0038.41 A

ATOM 2645 N PHE A 337 -33.764-29.427-25.233 1.0038.07 A

ATOM 2646 CA PHE A 337 -33.681-29.815-23.825 1.0038.41 A

ATOM 2647 CB PHE A 337 -34.916-29.327-23.055 1.0038.35 A

ATOM 2648 CG PHE A 337 -34.926-27.845-22.7701.0038.46 A ATOM 2649 CDl PHE A 337 -35.230-26.925-23.774 1.0037.31 A

ATOM 2650 CD2 PHE A 337 -34.663-27.371-21.481 1.0038.07 A

ATOM 2651 CEl PHE A 337 -35.278-25.544-23.499 1.0035.95 A

ATOM 2652 CE2 PHE A 337 -34.706-26.001-21.1941.0038.33 A ATOM 2653 CZ PHE A 337 -35.017-25.082-22.208 1.0036.81 A

ATOM 265^"4 C PHE A 337 -33.503-31.312-23.5691.0038.17 A

ATOM 2655 O PHE A 337 -33.529-31.749-22.424 1.0038.13 A

ATOM 2656 N TYRA 338 -33.332-32.091-24.628 1.0038.35 A

ATOM 2657 CA TYRA 338- -33.137-33.535 -24.502 l^'.OO 39.02 A ATOM 2658 CB TYRA 338 -31.731-33.821-23.973 1.0039.49 A

ATOM 2659 CG TYR A 338 -30.654-33.403-24.9421.0041.28 A

ATOM 2660 CDl TYR A 338 -30.351 -32.058 -25.1471.0041.85 A

ATOM 2661 CEl TYR A 338 -29.403-31.671-26.0861.0043.04 A

ATOM 2662 CD2 TYR A 338 -29.978 -34.349 -25.6991.0041.89 A ATOM 2663 CE2 TYR A 338 -29.031-33.980-26.6391.0043.62 A

ATOM 2664 CZ TYRA 338 -28.747-32.641-26.8341.0044.33 A

ATOM .2665 GH TYR A 338 -27.833-32.287-27.809 1.0046.76 A

ATOM 2666 C TYR A 338 -34.170-34.280-23.6591.0039.09 A

ATOM 26670 TYRA 338 -33.858-35.273-23.003 1.0038.65 A ATOM 2668 N ASN A 339 -35.409-33.812-23.7041.0039.78 A

ATOM 2669 CA ASN A 339 -36.487 -34.434 -22.957 LOO 40.08 A

ATOM 2670 CB ASN A 339 -36.89S -33.515 -2LSΘ1 1-.0039.81 A

ATOM 2671 CG ASN A339 -37.743-32.346-22.2601.00.40:39 A

ATOM : 2672 ODl ASN A-339 -37J20 -31.969÷-23.437^~1.0041.41 A. ATΘM 2673 ND2-ASN A-339 -38.49-1 -31.757 -21.332 LOG 39.35 A

ATOM 2674- C ASNA 339 -37^83-34r702 -23.8841.0040.40 A

ATOM^" 2.675 O ASN A 339 -3878M -34.911 -23.427 bθO 40.77 A

ATOM 2676 N ARG A 3.40^" -37.436--34.677 -25.191 1,00.40.46. A

ATOM 2677 CA ARG A 340 -38.478-34.929-26.191 1.0040.15 A ATOM 2678 CB ARG A 340 -38.864-36:409-26.173 1.0038.95 A

ATOM 2679 CG ARG A 340 -37.783-37.327-26.691 1.0039.69 A

ATOM 2680 CD ARG A 340 -37.887-38.712-26.0871.0040.72 A

ATOM 2681 NE ARGA 340 -37.636-38.675-24.647 1.0042.72 A

ATOM 2682 CZ ARG A 340 -38.581-38.667-23.711 1.0042.69 A ATOM 2683 NHl ARG A 340 -39.865-38.701-24.045 1.0042.55 A

ATOM 2684 NH2 ARG A 340 -38.239-38.611-22.433 1.0043.16 A

ATOM 2685 C ARG A 340 -39.741-34.094-26.0341.0039.90 A

ATOM 2686 O ARG A 340 -40.710-34.307-26.7581.0040.12 A ATOM 2687 N LYS A 341 -39.739-33.113-25.1621.0040.32 A

ATOM 2688 CA LYS A 341 -40.911-32.307-24.8551.0041.89 A

ATOM 2689 CB LYS A 341 -41.266-32.528-23.4141.0042.25 A

ATOM 2690 CG LYS A 341 -42.689-32.503-23.0301.0042.88 A

ATOM 2691 CD LYS A 341 -42.863-31.927-21.641 LOO 43.46 A ATOM 2692 CE LYS A 341 -43.858-30.810-21.581 1.0043.41 A

ATOM 2693 NZ LYS A 341 -44.044 -30.295 -20.23 L 1.0041.57 A

ATOM 2694 C LYS-A 341 -40.638-30.848-25.0471.0042.97 A

ATOM 2695 O LYS A 341 -41.375-30.195-25.7101.0042.21 A

ATOM 2696 N ASP A 342 -39.553-30.351-24.4681.0044.11 A ATOM 2697 CA ASP A 342 -39.157 -28.944 -24.4891.0044.52 A

ATOM 2698 CB ASP A 342 -38.560-28.558-23.131 1.0046.94 A

ATOM 2699 CG ASP A 342 -39J73 -27.912 -22.201 1.0048.S6 A

ATOM 2700 ODl ASP A 342 -40.685-28.459-22.038 1.0049.85 A

ATOM 2701 OD2ASPA342 -39.246-26.854-21.6191.0051.55 A ATOM 2702 C ASP A 342 -38.164-28.571-25.571 1.0043.48 A

ATOM 2703 O ASP A 342 -37.020 -29.029 -25.5621.0043.17 A

ATOM 2704 N PHEA 343 -38.616-27.722-26.491 1.0042.53 A

ATOM 2705 CA PHE A 343 -37.799 -27.210 -27.603: 1.0040.78 A

ATΘM^' 2706 CB PHE A 343 -38.145 -27.946-28.920 k0037.68 A ATOM 2707 CG PHE A343 -38.231 -29.45O.-28.810- LOO 36.00 A

ATOM -2708 CDl ^"PHE A 343 -39.457 -30.075 -28.582 1.0034^52 A

ATOM 2709 CD2PHEA343 -37.092-30.242-28.951 1.0035723 A

ATOM 2710 CEl PHE A 343 -39.548 -31.462 -28.49S 1.0034.50 A

ATOM 2711 CE2PHEA343 -37.173-31.629-28.8701.0035-37 A ATOM 2712 CZ PHE A 343 -3.8.406-32.239-28.6421.0035.35 A

ATOM 2713 C PHE A 343 -38.148-25.750-27.7401.0041.36 A

ATOM 2714 O PHE A 343 -39.308-25.405-27.9861.0041.25 A

ATOM 2715 N ARG A 344 -37.164-24.870-27.581 1.0042.08 A

ATOM 2716 CA ARG A 344 -37.452-23.438-27.6761.0042.64 A ATOM 2717 CB ARG A 344 -37.593-22.829-26.2781.0044.23 A

ATOM 2718 CG ARG A 344 -38.053-23.793-25.203 1.0047.79 A

ATOM 2719 CD ARG A 344 -38.267-23.054-23.901 1.0049.33 A

ATOM 2720 NE ARG A 344 -38.104-23.920-22.738 1.0051.50 A ATOM 2721 CZ ARGA 344 -38.145 -23.485 -2L482 1.0051.72 A-

ATOM 2722 NHl ARG A 344 -38.349-22.193-21.245 1.0052.80 A

ATOM 2723 NH2 ARG A 344 -37.966-24.333-20.470 1.0051.44 A

ATOM 2724 C ARG A 344 -36.421-22.623-28.446 1.0041.75 A

ATOM 2725 O ARG A 344 -35.312 -23^~.O78 -28.7141.0041.86 A ATOM 2726 N BLE A 345 -36.803-21.398-2877801.0040.33 A

ATOM 2727 CA ILE A 345 -35.930 -20.493^" -29.5021.0040.05 A

ATOM 2728 CB ILE A 345 -36.515 -.20.171 -30.8981.0039.92 A

ATOM 2729 CG2 ILE A 345 -35.901-18.892-31.448 1.0039.29 A

ATOM 2730 CGl DLE A 345 -36.296-21.369-31.8341.0039.58 A ATOM- 2731 CDl BLE A 345 -36.752-21.150-33.262 1.0036.26 A

ATOM 2732 C BLE A 345 -35.745-19.198-28.718 1.0040.50 A

ATOM 2733 O ELE A 345 -36.705-18.660-28.162 1.0041.70 A

ATOM 2734 N LYS A 346 -34.541-18.660-28.6741.0039.94 A

ATOM 2735 CA LYS A 346 -34.199-17.422-27.9831.0038.69 A ATOM 2736 CB LYS A 346 -33.112-17.723-26.9891.0037.09 A

ATOM 2737 CG LYS A ^"346 -32.590-16.622-26.1101.0034.23^" A

ATOM 2738 CD LYS A 346 -31.181 -L6.892 -25:693 LOO 32.44 A

ATOM- 2739 CE LYS A 346 -30.163-16.-3-52-26.684 L0032τ66 A

ATOM 274Ω NZ LYS A-34:6 _ -29d 55 -17.270 -27313 1.00-31.32. A ATOM 2741 C LYS A 346 -33.653 -16.423 -28.943.1.00-38.97 A

ATOM 2742 O LYS A 346^" -32.616 -16:595 -29.446170039.50 A

ATOM 2743 N GLN A 347 -34.373-15-370 -29.2161.003S:55 A

ATOM 2744 CA GLN A 347 -33.947-14358-30.213 1.0039.05 A

ATOM 2745 CB GLN A 347 -34.221-14.950-31.6041.0038.68 A ATOM 2746 CG GLN A 347 -33.932-13.975-32.7101.0039.12 A

ATOM 2747 CD GLN A 347 -34.500-14.435-34.0191.0039.67 A

ATOM 2748 OEl GLN A 347 -34.371-15.601-34.383 1.0040.23 A

ATOM 2749 NE2 GLN A 347 -35.133-13.521-34.743 1.0040.20 A

ATOM 2750 C GLN A 347 -34.642-13.054-30.073 1.0039.55 A ATOM 2751 O GLN A 347 -35.872-12.979-30.131 1.0039.14 A

ATOM 2752 N CYS A 348 -33.853-11.995-29.9091.0040.47 A

ATOM 2753 CA CYS A 348 -34.403-10.650-29.7651.0042.70 A

ATOM 2754 C CYSA 34R -34;872 -10.164 -31.140 1.0042.61 A ATOM 2755 O CYS A 348 -34.354 -9.190-31.691 LOO 43.38 A

ATOM^' 2756 CB CYS A 348 -33.350 -9.688-29.182 1.0044.58 A

ATOM 2757 SG CYS A 348 -32.665-10.127-27.537 1.0046.39 A

ATOM 2758 N THR A 349 -35.867-10.860-31.6761.0041.20 A

ATOM 2759 CA THR A 349 -36.421-10.566-32.989 1.0039.39 A ATOM 2760 CB THR A 349 -37:674-11.426-33.261 1.0039.50 A

ATOM 2761 OGl THR A 349 -37.364 -12.808 -33.050^" 1.0039.71 A

ATOM 2762 CG2THRA349 -38.150-1-1.241-34.6871.0038.77 A

ATOM 2763 C THR A 349 -36.796 -9.112-33.2261.0038.24 A

ATOM 2764 O THR A 349 -37.486 -8.496-32.425 LOQ.37.73 A ATOM 2765 N ALA A 350 -36.321 -8.586 -14.3481.0037.86 A

ATOM 2766 CA ALA A 350 -36.606 -7.228-34.7901.0037.83 A

ATOM 2767 CB ALA A 350 -35.311 -6.439-34.943 1.0037.69 A

ATOM 2768 C ALA A 350 -37.278 -7.440-36.1521.0038.23 A

ATOM 2769 O ALAA350 -36.843 -8.275-36.9381.0038.55 A ATOM 2770 N VAL A 351 -38.349 -6.711-36.4291.0038.82 A

ATOM 2771 CA VALA 351 -39.062 -6.872-37.693 1.0039.43 A

ATOM 2772 -CB VALA 351 -40398 -6.111-37.644 1.00-39.64 A

ATOM 2773 CGl VAL A 35 L -40.981 -5.969 -39.035 LOO 40.50 A

ATOM 2774 CG2. VAL A 351 -41.369 -6:862 -36.734 JLΘΘ-37.94- A ATOM 2775, C VAL A 351 -38.240 -6.430-38:9071.00.40.64 A

ATOM 2776 O- VALA 35T -38.272 -5.265-39.313 LOO 40JlQ A

ATOM 2777^{^}-N THR A 352 -37.516 -7.3&S -39.4861-.0Q 41.79 A

ATOM 2778 CA THRA 352 -36.646 -7.146-40.633 1.0041.94 A

ATOM 2779 CB THR A 352 -35.244 -6.784-40.145 1.0041.83 A ATOM 2780 OGl THR A 352 -35.304 -5.521-39.4841.0042.07 A

ATOM 2781 CG2THRA352 -34.266 -6.695-41.295 1.0043.79 A

ATOM 2782 C THR A 352 -36.557 -8.372-41.5371.0042.51 A

ATOM 2783 O THR A 352 -36.625 -9.500-41.061 1.0042.27 A

ATOM 2784 N MET A 353 -36.394 -8.153-42.839 1.0043.29 A ATOM 2785 CA MET A 353 -36.309 -9.272-43.758 1.0044.08 A

ATOM 2786 CB MET A 353 -36.152 -8.795-45.205 1.0047.53 A

ATOM 2787 CG MET A 353 -36.519 -9.861-46.251 1.0050.24 A

ATOM 2788 SD MET A 353 -36.263 -9.368-47.9971.0054,12 A ATOM 2789 CE MET A 353 -34.603-10.060-48.2971.0053.08 A

ATOM 2790 C META353 -35.145-10.159-4S.375 1.0043.41 A

ATOM 2791 O META353 -35.321-11.358-43.215 1.0042.34 A

ATOM 2792 N ASP A 354 -33.954 -9.587-43.217 1.0044.64 A

ATOM 2793 CA ASP A 354 -32.806-10.411-42.8391.0046.57 A ATOM 2794 CB ASP A 354 -31.499 -9.594 -42.702 LOO 48.00 A

ATΘM 2795 CG ASP A 354 -31.717 =8.077 -42.745 1.0051.83 A

ATOM 2796 ODl ASP A 354 -32,396 -7.580-43.675 1.0052.68 A

ATOM 2797 OD2 ASP A 354 -31.186 -7.371-41.8501.0054.11 A

ATOM 2798 C ASPA354 -33.111-11.141-41.5321.0047.53 A ATOM 2799 O ASP A 354 -32.511-12.174-41.231 1.0047.38 A

ATOM 2800 N GLN A 355 -34.132-10.704-40.838 1.0048.81 A

ATOM 2801 CA GLN A 355 -34.475-11.300-39.587 1.0048.08 A

ATOM 2802 CB GLN A 355 -34^43-10.270-38^561.0047.13 A

ATOM 2803 CG GLN A 355 -33.683 -9.789-37.770 1.0048.31 A ATOM 2804 CD GLN A 355 -33.594 -10.305 -36.3881.0048.09 A

ATOM 2805- OEl GEN A-355 -34.148 -9.774 -3SJ071.0048.37 A

ATOM ^80^"6^rNE2 GLN-A 335 -32.98241.406-36.235 1.0047.82 A

ATOM" 2807 C GLN-A 355 -35:550 -12.284 -39.7491.0047.78 A

ATOM 2808- O GLN A 355 -35.702 -13.129 -3-8.9541.0048.60 A ATOM-2849-N -LEU A 356- -36.295 -_12.169-40.807 1.0046.44 A

ATOM 28-10 CA LEU A 356, -37.297 -13.164 -4 L1761.0543.62 A

ATOM 2811 -CB_LEUA 356 -38.203-12.637-42:291 1.0042.36 A

ATOM 2812 CG LEUA356 -39r241 -13.630 -42.828 1.004L19 A

ATOM 2813 CD1LEUA356 -40.126-14.149-41.7041.0040.62 A ATOM 2814 CD2 LEU A 356 -40.081-12.947-43.8771.0039.57 A

ATOM 2815 C LEU A 356 -36.676-14.480-41.609 1.0042.99 A

ATOM 2816 O LEU A 356 -37.253-15.538-41.376 1.0043.36 A

ATOM 2817 N SER A 357 -35.505-14.423-42.2391.0042.07 A

ATOM 2818 CA SER A 357 -34.851-15.652-42.675 1.0041.18 A ATOM 2819 CB SERA 357 -33.919-15.393-43.865 1.0039.62 A

ATOM 2820 OG SER A 357 -32.977-14.394-43.5761.0038.03 A

ATOM 2821 C SER A 357 -34.095-16.289-41.522 1.0040.65 A

ATOM 28220 SERA 357 -33.914-17.505-41.4941.0040.23 A ATOM 2823 N THR A 358 -33.-659 -15.471 -40.5661.0040.85 A

ATOM 2824 CA THR A 358 -32.958.-15.993-39.396170040.86 A

ATOM 2825 CB THR A 358 -32.406-14.875-38.492 1.0040.84 A

ATOM 2826 OGl THR A 358 -31.246-14.285-39.0971.0039.27 A

ATOM 2827 CG2 THRA 358 -32.036-15.443-37.1221.0040.75 A ATOM 2828 C THRA 358 -33.981-16.786-38.595 1.0040.77 A

ATOM 28290 THR A 358 -33.651-17.766-37.922 1.0039.94 A

ATOM 2830 N VAL A 359 -35.231-16.350-38.6681.0040.24- A

ATOM 2831 CA VAL A 359 -36.290-17.050-37.971 1.0039.58 A

ATOM 2832 CB VAL A 359 -37.620-16.279-38.043 1.0039.32 A ATOM 2833 CGl VAL A 359 -38.758 -17.153 -377539 -1.0039-.04 A

ATOM 2834 CG2 VAL A 359 -37.520-15.010-37.199 1.0038.97 A

ATOM 2S35 C VALA 359 -36.442-18.418-38.618 1.0039.18 A

ATOM 2836 O VAL A 359 -36.568-19.422-37.915 1.0039.87 A

ATOM 2837 N HIS A 360 -36.417-18.462-39.951 1.0037.66 A ATOM 2838 CA HIS A 360 -36.525-19.738-40.6571.0036.81 A

ATOM 2839 CB HIS A 360 -J36.575 -19-536 -427171 1.0035.97 A

ATOM 2840 CG HIS A 360 -37.878 -ES994 -42.6661.0037.14 A-

ATOM .2841 CD2-HIS-A 360 -38r898 -19.589 -43.3291.00.3-7r42 A

ATΘM 2842 NDl HIS A 360 -38.253-17.679 -42.4991.0038.78 A ATOM 2843 CE1HISA360 -39F446-17.486 -43.024 ITOO 39.34 A

ATOM 2844 NE2 HIS A 360- -39.862-18.629-43.5401-00-39.00 A

ATOM 2845 C HIS A 360 -35.321 -20ϋ602_-40.301 170035.68 A

ATOM 2846 O HIS A 360 -35.455 -21.795 -40.0071.0034.B A

ATOM 2847 N HISA361 -34.147-19.980-40.321 1.0034.03 A ATOM 2848 CA HIS A 361 -32.903-20.659-39.9881.0033.65 A

ATOM 2849 CB HIS A 361 -31.768-19.650-39.8821.0033.34 A

ATOM 2850 CG HIS A 361 -30.5.13-20.221-39.3021.0031.80 A

ATOM 2851 CD2HISA361 -29.993-20.140-38.0581.0031.41 A

ATOM 2852 NDI HIS A 361 -29.648-21.007-40.0271.0031.30 A ATOM 2853 CEl HIS A 361 -28.647-21.386-39.2541.0030.91 A

ATOM 2854 NE2HISA361 -28.832-20.874-38.053 1.0031.01 A

ATOM 2855 C HIS A 361 -33.016-21.388-38.6591.0033.70 A

ATOM 28560 HIS A 361 -32.649-22.561-38.543 1.0032.65 A ATOM 2857 N GLU A 362 -33.513-20.669-37.655 1.0034:07 A

ATOM 2858 CA GLU A 362 -33.680-21.218-36.3191.0033.62 A

ATOM 2859 CB GLU A 362 -34.036-20.100-35.333 1.0033.93 A

ATOM 2860 CG GLU A 362 -32.940-19.044-35.1371.0034.15 A

ATOM 2861 CD GLU A 362 -31.596-19:639-34.7541.0035.22 A ATOM 2862 OEl GLU A 362 -31.574-20.670-34.0701.0036.91 A

ATOM 2863- OE2 GLU A 362 -30.551-19.071-35.1161.0035.16 A

ATOM 2864 C GLU A 362 -34.738-22.325-36.297 LOO 33.91 A

ATOM 2865 O GLU A 362 -34.499-23.392-35.720 1.0033.70 A

ATOM 2866 N MET A 363 -35.893-22.085-36.9241.0033.63 A ATOM 2867 CA ^"MET A 363 -36.945 -23 „102 -36.981 1.0034.31- A

ATOM 2868 CB MET A 363 -38.100-22.649-37.863 1.0035.71 A

ATOM 2869 CG MET A 363 -39.049-21.692-37.2061.0038.96 A

ATOM 2870 SD MET A 363 -40.759-22.252-37.3921.0041.06 A

ATOM 2871 CE MET A 363 -41.588-21.035-36.3301.0039.57 A ATOM 2872 C META 363 -36.373-24.383-37.571 1.0034.10 A

ATOM 2873 O MET A 363 -36.830-25.481-37.275 1-.00-33.78 A

ATOM 2874 N GLY A 364 -35375-24.225-38.4281.0033.86 A

ATOM 28-75 CA GLY A 364 -34.756-25.375-39_^043 1.0033.52 A.

ATOM 2876 C GLYA364 -34.107^26,247-38.0041.0633.69 A ATOM 28-77 Θ -GLY A 364 -34.GS2 -27.460 -38.158 1.003433 ^~A

ATOM 2878 N KIS=A-SOD -33.567-25.635 -36.953^~L003407 A

ATOM 2879 CA HIS A 365 -32.927 -2&.383 -35:8671.0034:86 A

ATOM 288XJT CB HIS A 365 -32.141-25.436-34.958 1.0033.95 A

ATOM 2881 CG HIS A 365 -30.864 -24.947 -35J61 1.0034.55 A ATOM 28S2 CD2HISA365 -30.405 -23:692 -35.790 1.00T34.78 A

ATOM 2883 NDl HIS A 365 -29.876-25.803-36.0001.0033.79 A

ATOM 2884 CEl HIS A 365 -28.863 -25.096 -36.4721.0034.38 A

ATOM 2885 NE2 HIS A 365 -29.159-23.813-36.3571.0033.95 A

ATOM 2886 C HIS A 365 -33.997 -27.105 -35.047 1.0035.07 A ATOM 2887 O HIS A 365 -33.877-28.299-34.752 1.0033.51 A

ATOM 2888 N ELE A 366 -35.042 -26.360 -34.6961.0034.86 A

ATOM 2889 CA ILE A 366 -36.163-26.888-33.9361.0035.34 A

ATOM 2890 CB BLE A 366 -37.239-25.799-33.741 1.003.5.51 A ATOM 2891 CG2DLEA366 -38.415-26.349-32.965 1.0035.57 A

ATOM 2892 CGl ELE A 366 -36.623-24.593-33.033 1.0035.55 A

ATOM 2893 CDl ELE A 366 -35.759-24.958-31.845 1.0036.59 A

ATOM 2894 C ELE A 366 -36.788-28.087-34.652 1.0035.58 A

ATOM 2895 O ILEA 366 -37.058 -29.1 T8 -34.032 1.0035.58 A ATOM 2896 N GLN A 367 -37.Q06 -27.943 -35.959 1.0035.53 A

ATOM 2897 CA GLN A 367 -37.600 -29.005 -36.7&8 1.0035.60 A

ATOM 2898 CB GLN A 367 -37:S71 -28.527 -38.195 1.0034.08 A

ATOM 2899 CG GLN A 367 -38.606-29.563-39.0401.0033.86 A

ATOM 2900 CD GLN A 367 -40.074-29.697-38.6681.0034.01 A ATOM 290L OElGLN A 367 -40.688-30.742-38.875 LOO 35.15 A

ATOM 2902 NE2 GLN A 367 -40.646-28.630-38.1321.0033.31 A

ATOM 2903 C GLN A 367 -36.702-30.229-36.8281.0036.04 A

ATOM 2904 O GLN A 367 -37.186 -31,349 -36.9881.0036.40- A

ATOM 2905 N TYR A 368 -35.396-30.017-36.7071.0035.45 A ATOM 2906 CA TYR A 368 -34.462 -3 L120 -36.7441.0035.55 A

ATOM 2907 CB TYRA 36S -33.039-30.600-36.923 1.0035.74 A

ATOM^ 2908 GG TYR A 3.68 -32.116-31.545-37.6701.003X21 A

ATOM 2909 CDl-TYRA 368_ -30.992-31.065-38.348 1.00-37,93 A-

ATOM 29-10 CEl TYR A 368 -30.121-31.929 -39.022 1.Q0-38.53 A ATOM 2911 GD2 TYR-A 36:8 -32.348 -32.916 -37.6891.0038^95 A

ATOM 29Ϊ2 CE2TYRA368 -31.485 -33.78-9-- -38τ3621.0039.18 A

ATOM 2913 CZ TYR A 368 -30,37Ϊ^~-33,291^~39.025 1.00-39.10 A

ATOM 29-14 OH TYRA 368 -29.500-34.155-39.666 1.0037.48 A.

ATOM 2915 C TYRA 368 -34,609-31.848-35.4201.0036.64 A ATOM 2916 O TYRA 368 -34.580-33.075-35.3741.0036.91 A

ATOM 2917 N TYR A 369 -34.791-31.082-34.3441.0037.50 A

ATOM 2918 CA TYR A 369 -34.959-31.646-33.003 1.0037.48 A

ATOM 2919 CB TYRA369 -35.098-30.536-31.961 1.0035.62 A

ATOM 2920 CG TYR A 369 -33.899-29.635-31.8501.0033.19 A ATOM 2921 CDl TYRA 369 -34.057-28.275-31.6181.0032.92 A

ATOM 2922 CEl TYR A 369 -32.964-27.434-31.531 1.0034.36 A

ATOM 2923 CD2TYRA369 -32.612-30.139-31.986 1.0032.70 A

ATOM 2924 CE2 TYR A 369 -31.506-29.309-31.9001.0034.01 A ATOM 2925 CZ TYRA 369 -31.689-27.953-31.675 1.0035.30 A

ATOM 2926 OH TYR A 369 -30.598-27.112-31.6161.0036.23 A

ATOM 2927 C TYRA 369 -36.213-32.493-32.971 1.0038.49 A

ATOM 2928 O TYR A 369 -36.166-33.680-32.650 1.0039.60 A

ATOM 2929 N LEU A 370 -37.334-31.862-33.307 1.0038.26 A ATOM 2930 CA LEU A 370 -3Ε.627 -32.528 -33.326 1.0037.47 A

ATOM 2931 CB LEU A 370 -39.681-31.615-33.958 1.0034.09 A

ATGM 2932 CG LEU A 370 -39.867-30.226-33.358 1.0032.59 A

ATOM 2933 CDl LEU A 370 -40.775-29.406-34.245 1.0032.73 A

ATOM 2934 CD2 LEU A 370 -40.441-30.349-31.973 1.0032.20 A ATOM 2935 C LEU A 370 -38.567-33.832-34.111 1.0038.97 A

ATOM 2936 O LEU A 370 -39.213-34.807-33.7481.0040.37 A

ATOM 2937 N GLN A 371 -37.783-33.856-35.180 1.0040.33 A

ATOM 2938 CA GLN A 371 -37.699-35.050-36.014 1.0041.82 A

ATOM 2939 CB GLN A 371 -37.193-34.693-37.4201.0042.99 A ATOM 2940 CG- GLN A 371 -38.129-33.803-38.2491.0041.62 A

ATOM 2941 CD GLNA371 -39.520 -34.384- -38.4101.0040.46 A

ATOM 2942 OEl GLN A 371 -39,696 -3-5.601 -38.488 LQO 39:12 A

ATOM 2943. NE2 GLN A 371 -40.516-33.513 -38.477 LOO 39.61 A

ATOM 2944_C GLNA 371 -36.870 -36.206 -35.467 : T.OΘ-42.33^" A ATOM 2945 O GLN A 371 -37.235_-37.364 -35.670 LQO.43.17 A

ATOM 2946 N TYR A 372 -35.765-^"35.927 -34J7-85 1.0042.69 A

ATOM 2^47 CA TYR-A 372 -34.965 -37.035 -34.282 LOO 44.21- A

ATOM 2948 CB TYRA 372^ -33.479-36.872-34.671 1.0045.88 A

ATOM 2949 CG TYR A 372 -32.744-35.624-34.189 1.0047.12 A ATOM 2950 CDl TYR A 372 -33.264-34.794-33.193 1.0047.39 A

ATOM 2951 CEl TYR A 372 -32.540-33.688-32.7191.0047.90 A

ATOM 2952 CD2TYRA372 -31.486-35.313-34.705 1.0048.58 A

ATOM 2953 CE2TYRA372 -30.758-34.212-34.241 1.0049.61 A

ATOM 2954 CZ TYRA 372 -31.285-33.406-33.2501.0048.82 A , ₇,

173

ATOM 2955 OH TYR A 372 -30.542-32.338-32.795 1.0047.60 A

ATOM 2956 C TYR A 372 -35.087-37.315-32.790 1.0044.50 A

ATOM 2957 O TYR A 372 -34.360-38.164-32.251 1.0044.28 A

ATOM 2958 N LYS A 373 -36.024-36.634-32.129 1.0044.11 A ATOM 2959 CA LYS A 373 -36.220--36.815 -30.6901.0043-18 A

ATOM 2960 CB LYS A 373 -37.437-36.017-30.2041.0042.04 A

ATOM 2961 CG LYS A 373 -38.785-36.531-30.6741.0041.69 A

ATOM 2962 CD LYS A 373 -39.900-35.630-30.1501.0042.07 A

ATOM' 2963- CE LYS A 373 -41.268 -35.981 -30.73T 1.0041.86 A ATOM 2964 NZ LYS A 373 -41.712-37.361-30.3881.0041.51 A

ATOM 2965 C LYS A 3-73 -36.380-38.280-30.2881.0043.21 A

ATOM 2966 O LYS A 373 -36.198-38.624-29.12.41.0043.14 A

ATOM 2967 N ASP A 374 -36.696-39.145-31.2461.0043.39 A

ATOM 2968 CA ASP A 374 -36.881-40.554-30.9471.0043.26 A ATOM 2969 CB ASP-A 374 -38.095 -4L076-31.6961.0046.24 A

ATOM 2970 CG ASP A 374 -39.382-40.458-31.191 1.0050.04 A

ATOM 2971 ODl ASP A 374 -39.625 -40.531 -29.9601.0051.44 A

ATOM 2972 OD2 ASP A 374 -40.143-39.897-32.013 1.0051.92 A

ATOM 2973 C ASP A 374 -35.681-41.442-31.2091.0042.09 A ATOM 2974 O ASP A 374 -35.816-42.527-31.7571.0042.02 A

ATOM 2975 N LEUA 375 -34.51O -40.980 -30.788 1.0041.94 A

ATOM- 2976 CA LEU A 375- -33.269 -4 £728- -30.9571.0041.84 A

ATOM 2977 CB- LEU A 375 -32.433-41.123-32.091 1.0043.30 A

ATOM.2978 CG LEU A.3.75 -33.024 -4:bO38 -33.499 1.0043.82 A ATOM 2979 CDl LEU A 375 -32.274 -33.990~-34.3061.0044.15- A--

ATΘM 298O CD2LEUA375 -32.952 -42.402-34.161- ITOO 43.55- A

ATOM 2981 C LEU A 375 -32.454-41 JS40 -29.6741.0040.70 A

ATOM 2982 O LEU A 375 -32.677-40.752-28.852 IjQO 39.20 A

ATOM 2983 N PRO A 376 -31.508-42.573-29.4781.0040.63 A ATOM 2984 CD PRO A 376 -31.149-43.761-30.2741.0040.97 A

ATOM 2985 CA PRO A 376 -30.701-42.500-28.2641.0040.75 A

ATOM 2986 CB PRO A 376 -29.571 -43.479 -28.558 1.0040.90 A

ATOM 2987 CG PRO A 376 -30.277-44.551-29.311 1.0040.74 A

ATOM 2988 C PRO A 376 -30.210-41.059-28.165 1.0040.76 A ATOM 2989 O PRO A 376 -29.806-40.468-29.165 1.0042.46 A

ATOM 2990 N VAL A 377 -30.277-40.488-26.971 1.0039.66 A

ATOM 2991 CA VAL A 377 -29.844-39.114-26.745 1.0037.92 A

ATOM 2992 CB VAL A 377 -29.704-38.836-25.220 1. OQ 36.49 A ATOM 2993 CGl VAL A 377 -28.517-39.608-24.6471.0037.67 A

ATOM 2994 CG2 VAL A 377 -29.556 -37.367 -24.9661.0034.14 A

ATOM 2995 C VAL A 377 -28.521-38.769-27.453 1.0037.64 A

ATOM 2996 O VAL A 377 -28.445-37.779-28.180 1.0037.60 A

ATOM ^"2997 N SER A 378 -27:491 -39.588 -27.2591.0036.49 A ATOM 2998 CA SER A 378 -26.192-39.317-27.8601.0036.63 A

ATOM 2999 CB^" SER-A 378 -25.167-40.336-27.3621.0036.94 A

ATOM 3000 OG SER A 378 -25.657-41.653-27.5171.00-39.91 A

ATOM 3001 C SER A 378 -26.165-39.253-29.389 1.0035.84 A

ATOM 3002 O SER A 378 -25.116-39.014-29.9791.0034.67 A ATOM 30Θ3-TST LEU A 379 -27.311-39.459-30:0281.0036.12 A-

ATOM 3004 CA LEU A 379 -27J92 -39.398 -31.485 1.0036.83 A

ATOM 3005 CB LEU A 379 -27.896-40.723-32.0661.0036:62 A

ATOM 3006 CG LEU A 379 -27.108-42.020-31.8491.0036.80 A

ATOM 3007 CDl LEU A 379 -27.862-43.168-32.495 1.0035.69 A ATOM 3008 CD2 LEU A 379 -25.728-41.917-32.4441.0036.45 A

ATOM 3Θ09 C LEU A 379 -28.320-38.270-31.9541.0037.73 A

ATOM -30T0 -O LEU A 379- -28-655-S8.195-33.136 1.0037.il A

ATOM- 3011 N ARG A- 380 -28.733 -37.4ΘQ -31.0321.0039.25 A

ATOM 3012 CA ARGA 3=80: -=29.623 -36.283 -3-13671.0040=66- A - ATOM 3013- CB-ARG-A 3StT -30.497-35.904-30.1591.0042.63 A

ATOM 3014- GG- ARG A 380 -31.322 -37:066-29.630^" 1:0043.lt A

ATOM 3015'CD ARG A 380- -32.250 -36.697 -28.4821.0β^~43.72 A

ATOM 3016 NE ARG A 380 -32.791 -37.919 -27.878 1.0045.88 A

ATOM 30-17.CZ ARG A 380 -33.611-37.958-26.829 1.0045.83 A ATOM 3018 NHl ARG A 380 -34.011-36.835-26.238 1.0044.45 A

ATOM 3019 NH2 ARG A 380 -34.030-39.129-26.3661.0046.80 A

ATOM 3020 C ARGA 380 -28.820-35.072-31.832 1.0040.70 A

ATOM 3021 O ARG A 380 -28.738-34.039-31.148 1.0040.70 A

ATOM 3022 N ARGA 381 -28.204-35.234-32.989 1.0040.89 A ATOM 3023 CA ARGA 381 -27.228-34.356-33.5901.0040.63 A

ATOM 3024 CB ARG A 381 -25.912-35.107-33.4571.0042.06 A

ATOM 3025 CG ARG A 381 -25.121-34.798-32.2901.0042.26 A

ATOM 3026 CD ARG A 381- -25.766-33.841-31.4301.0045.08 A ATOM 3027 NE- ARGA 38t -24.839^32.818-30.9761.0048.47 A

ATOM 3028^" CZ. ARGA 381 -25.127 -3 H572 -3O.662 1.0049.05 A

ATOM 3029 NHl ARGA 381 -26.333-31.086-30.742 1.0048.20 A

ATOM 3030 NH2 ARG A 381 -24.147 -30.804 -30.2871.0049.59 A

ATOM 3031 C ARGA 381 -27:657-34.270-35.089 1.0039.16 A ATOM 3032 O ARGA 381 -28.411-35.066-35.456 1.0039.48 A

ATOM 3033 N^" GLY A 382 -27.192^~-33.349 -35.938 LOG 37.16 A

ATOM 3034 CA GLY A 382 -27.314-33.456-37.3861.0035.25 A

ATOM 3035 C GLYA 382 -26.297-34.434-37.946 1.0033.42 A

ATOM 3036 O GLYA.382 -25.360-34.800-37.241 1.0033.53 A ATOM 3037 N ALAA 383 -26.478-34.871-39.191 1.0032.75 A

ATOM 3038 CA ALAA 383 -25.535-35.809-39.815 1.0031.91 A

ATOM 3039 CB ALA A 383 -25.734 -35.837 -41.J23 1.0033.76 A

ATOM 3040 C ALA A 383 -24.144-35.308-39.472 1.0030.27 A

ATOM 3041 O ALAA 383 -23.248-36.083-39.1361.0029.89 A ATOM 3042 N ASN A 384 -23.989-33.995-39.603 1.0028.03 A

ATOM 3043 CA ASN A384 -22.-785 -33.273 -39.2271.002&64 A

ATOM 3044 CB ASNA 384 -21.659-33 J31 -40.295 1.003.0.24 A

ATOM- 3045 CG ASN A_3_84 -21.994 -32J6.05^÷-41-6021.0031.98 A

ATOM 3046_^.ODl A-SN A 384 -22.546-31.503 -41.6*9 1.00-33.11 A ATOM 3047 ND2-ASN-A 384 -21.61-1-33-219 -42 Jl 8 LOQ 29.17 A

ATOM ^~3048 C ASN-A 384 -23.300 -3 h-865 -38:9581.09-28.56 A

ATOM^" 3049 -O ASN A3S4- -24.369 -31 v488 -39.451" ΪΛO 27.53 A

ATOM 3050 N PRO A 385 -22.575-31.081-38.145 1.0028.5-1 A

ATOM 3051 CD PRO A 385 -21.184-31.334-37.731 1.0027.49 A ATOM 3052 CA PRO A 385 -22.974-29.712-37.801 1.0028.96 A

ATOM 3053 CB PRO A 385 -21.703-29.117-37211 1.0028.26 A

ATOM 3054 CG ERO A 385 -21.002-30.312-36.658 1.0027.98 A

ATOM 3055 C PRO A 385 -23.471-28.922-39.003 1.003029 A

ATOM 3056 O PRO A 385 -24.345-28.059-38.8751.0032.12 A ATOM 3057 N GLY A 386 -22.902-29.223-40.1681.0029.85 A

ATOM 3058 CA GLY A 386 -23.285-28.541-41.3861.0028.62 A

ATOM 3059 C GLY A 386 -24.734-28.769-41.7471.0029.23 A

ATOM 3060 O GLY A 386 -25.450-27.812-42.0221.0029.20 A ATOM 3061 N PHE A 387 -25.173 -30.026--4r.7521.0029.65 A

ATOM 3062 CA PHE A 387 -26.563 -30.326-42.0821.-0Q 30.14 A

ATOM 3063 CB PHE A 387 -26.869-31.817-41.885 1.0030.04 A

ATOM 3064 CG PHE A 387 -26.269-32.719-42.9391.0030.84 A

ATOM 3065 CDl PHE A 387 -24.892 -32.735 -43.1761.003T.00 A ATOM 3066 CD2 PHE A 387 -27.080 -33.585 -43.6731.0029.77 A

ATOM 3067 CEl PHE A 387 -24.334 -33:606 -44.131 1.0030.68" A

ATOM 3068 CE2PHEA3S7 -26.5-31-34.457-44.6271.0030.22 A

ATOM 3069 CZ PHE A 387 -25.158-34.468-44.855 1.0029.38 A

ATOM 3070 C PHE A 387 -27.496 -29.504 -41 J98 1.0030.14 A ATOM 3071 O PHE A 387 -28.506-28.980-41.666 1.00^~29735 A

ATOM 3072 N HIS A 388 -27.142-29.379-39.921 1.0029.68 A

ATOM 3073 CA HIS A 388 -27.974-28.635-38.9901.0029.23 A

ATOM 3074 CB HIS A 388 -27.406-28.699-37.5621.0029.87 A

ATOM 3075 CG HIS A 388 -28.407-29.145-36.5261. OO 30.57 A ATOM 3076 CD2 HIS A 388 -28.415-30.213-35.695 1.0030.18 A

ATOM 3077 NDl HIS A 388 -29.587-28-465-36.283 1.00^"30.8I A

ATOM 3078 CEl HIS-A 388 -30.276-29.099-35^".3521.0030.Io A

ATOM 3079 NE2-HIS A-388 -2-9.590 -30.162-34.9761.0030.14 A

ATOM 3080 C HISA 388 -28.149-27,193-357413 1.0028.54 A ATOM 3081 O HIS A 388 -29.274 -26.709^~39.502 1.0029.28 A

AT-QM- 3082 N GLUA 389 -27X51-26.500-39.689 1.0028.07 A-

ATOM 3083 CA GLU-A 389 -27.149 -25.O98-4O.J0891.0028.29 A

ATOM 3084 CB GLUA389 -25.761-24.452-40.1201.0028.13 A

ATOM 3085 CG GLU A 389 -24.943-24.544-38.820 1.0029.84 A ATOM 3086 CD GLU A 389 -25.696-24.021-37.6001.0030.64 A

ATOM 3087 OEl GLU A 389 -26.468-23.051-37.7321.0030.20 A

ATOM 3088 OE2 GLUA 389 -25.500-24.574-36.499 1.0030.65 A

ATOM 3089 C GLU A 389 -27.825-24.915-41.453 1.0028.36 A

ATOM 3090 O GLU A 389 -28.266-23.815-41.795 1.0029.82 A ATOM 3091 N ALA A 390 -27.901-25.997-42.221 1.0026.14 A

ATOM 3092 CA ALA A 390 -28.527-25.959-43.5371.0023.23 A

ATOM 3093 CB ALA A 390 -28.124-27.179-44.352 1.0023.61 A

ATOM 3094 C ALA A 390 -30.046-25.872-43.4241.0023.38 A ATOM 3095 O ALA A 390 -30.685-25.081-44.1171.0022.78 A

ATOM 3096 N ILE A 391 -30.616-26.690-42.5461.0023.42 A

ATOM 3097 CA ILE A 391 -31.985-27.162-42.716 1.0022.36 A

ATOM 3098 CB ILE A 391 -32.419-28.008-41.5041.0020.22 A

ATOM 3099 CG2 LLE A 391 -33.909-28.305-41.5671.0016.75 A ATOM 3100 CGl BLE A 391 -31.611-29.305-41.4421.0020.32 A

ATOM 3101 CD1ILEA391 -31.-501-30.019-42.771 1.0019.50 A

ATOM 3102 C DLE A 391 -32.950 -25.998 -42.914 IJQO 23.56 A

ATOM 3103 O ILE A 391 -33.849-26.059-43.7531.0024.41 A

ATOM 3104 N GLY A 392 -32.758-24.938-42.1361.0024.03 A ATOM 3105 CA GLYA 392 -33.619-23.772-42.2091.0025.24 A

ATOM 3106 C GLY A 392 -33.303-22.893-43.4031.0026.93 A

ATOM 3107 O GLYA 392 -34.193-22.264-43.975 1.0027.39 A

ATOM 3108 N ASPA393 -32.030-22.851-43.782 1.0029.78 A

ATOM 3109 CA ASPA 393 -31.590-22.029-44.902 1.0030.91 A ATOM 3110 CB ASPA 393 -30.062-22.004-44.9821.0033.01 A

ATOM 3111 CG ASPA 393 -29.451-20.924-44.110 1.0035.37 A,

ATOM 3112 ODl ASP A 393 -29.786 -20.868 -42.908 IJ)O 34.06 A

ATOM 3113 ΘD2ASPA393 -28.628-20.089-44.53,8 kOO-37.74 A

ATOM 3114 C ASP A 393 =32-176-22.532-46^181.0030.46 Λ ATOM 311-5 O A-SP A 593 -32.612 -21.742-47.055- 1.0030.15 A

ATOM 31T6 N VAL A 394 -J2T182 -23.849-46.393 1.0030.O6 A

ATOM 3117 CA VAL A 394 -32.780 -24.464 -4-7r57S~l.00^{^}29.38 A

ATOM 3118 CB VAL A 394 -32.974-25.976-47.3991.0027.50 A

ATOM 3119 CGl VAL A 394 -33.667 -26.543 -48.6061.0CL25.21 A ATOM 3120 CG2 VAL A 394 -31.639-26.660-47.1881.0027.06 A

ATOM 3121 C VAL A 394 -34.159-23.841-47.813 1.0030.78 A

ATOM 3122 O VAL A 394 -34.371-23.117-48.7881.0031.67 A

ATOM 3123 N LEUA 395 -35.094-24.123-46.9081.0031.02 A

ATOM 3124 CA LEU A 395 -36.447-23.587-47.0071.0030.35 A ATOM 3125 CB LEUA 395 -37.275-23.938-45.7661.0029.21 A

ATOM 3126 CG LEU A 395 -37.739-25.380-45.585 1.0029.04 A

ATOM 3127 CDl LEU A 395 -36.565-26.295-45.245 1.0028.67 A

ATOM 3128 CD2 LEU A 395 -38.771 -25.404 -44.4841.0028JiO A ATOM 3129 C JLEU A 395 -36.428-22.079-47.1741.0030.38 A

ATOM 3130 O LEU A 395 -37.343-21.505-47.753 1.0031.31 A

ATOM 3131 N ALA A 396 -35.395-21.432-46.658 1.0029.84 A

ATOM 3132 CA ALA A 396 -35.303-19.987-46.7881.0030.81 A

ATOM 3133 CB ALA A 396 -34.127 -19.467 -45.993^" 1.0032.14 A ATOM 3134 C ALA A 396 -35.148-19.605-48.2621.0031.43 A

ATOM 3135 O ALAA396 -35.729-18.608-48.7141.0031.32 A

ATOM 3136 N LEU A 397 -34.371- -20.402 -49.0061.0031.49 A

ATOM 3137 CA LEU A 397 -34.132-20.152-50.4341.0030.57 A

ATOM 3138 CB LEU A 397 -33.337 ^'-21. ,29 »4 -51.07 '51.0028.20 A ATOM 3139 CG LEU A 397 -31.837-21.312-50.763 T.0027.50 A

ATOM 3140 CDl LEU A 397 -31.204-22.558-51.3401.0026.24 A

ATOM 3141 CD2LEUA397 -31.171-20.072-51.325 1.0025.83 A

ATOM 3142 C LEU A 397 -35.446-19.985-51.161 1.0031.24 A

ATOM 3143 O LEU A 397 -35.624-19,020-51.9121.0032.54 A ATOM 3144 N SERA 398 -36.369-20.914-50.9201.0031.26 A

ATOM 3145 CA SERA 39S -37.679-20.875-51.553 1.0030.66 A

ATOM 3146 CB^ SER A 398 -38.452 -22.170-51.264 k0029.37 A

ATOM 3-147 OG SERA 398 -37.731 -.23.325 -51.672- 1.0027.56 A

ATOM 3148 C SER,A398^~ -3-8^88T-19τ667 -5-1.075 1.003133 A- ATOM 3149 O SEELA.398- -39r273 -15.102 -5-K825- MO 32.06 A

ATOM 3450 N VAE A 399 -3:8,296-19:251-49.833 hQQM.71 A

ATOM- 3151 CA VAL A 399 -39.061-18.123 -49T331 ITBO 32.24 A

ATOM 3152 CB VAL A 399 -38.953-18.011-47:788 1.0032,17 A

ATOM 3153 CGl VAL A 399 -39.932-16.965-47.259 LOO 29.97 A ATOM 3154 CG2 VAL A 399 -39.223 -19.359 -47.154 IJ)O 31.41 A

ATOM 3155 C VALA399 -38.593-16.819-49.958 1.0033.12 A

ATOM 31560 VAL A 399 -39.402-15.971-50.308 1.0033.08 A

ATOM 3157 N SER A 400 -37.286-16.665-50.1121.0033.88 A

ATOM 3158 CA SER A 400 -36.727-15.440-50.6821.0035.80 A ATOM 3159 CB SERA 400 -35.207-15.497-50.625 1.0036.18 A

ATOM 3160 OG SER A 400 -34.781-15.742-49.303 1.0038.27 A

ATOM 3161 C SER A 400 -37.150-15.107-52.118 1.0036.52 A

ATOM 3162 Q SER A 400 -37.155-13.933-52.505 1.0034.84 A ATOM 3163 N THRA 401 -37.493-16.133-52.9001.0037.13 A

ATOM 3164 CA THR A401 -37.888-15.932-54.2951.0037.30 A

ATOM 3165 CB THR A 401 -38.338-17.252-54.9671.0037.10 A

ATOM 3166 OGl THR A 401 -39.593-17.668-54.421 1.0036.11 A

ATOM 3167 CG2 THRA 401 -377304-18.347-54.759 1.0036.99 A ATOM 3168 C THRA 401 -39.017-14.917-54.450 1.0038.52 A

ATOM 3169 O THRA 401 -40.007-14.961-53.723 1.0037.77 A

ATOM 3170 -N PRO A 402 -3O86-13.994-55.420 1.0039.99 A

ATOM 3171 CD PRO A 402 -37.767-13.852-56.369 1.0039.57 A

ATOM 3172 CA PRO A 402 -39.904-12.966-55.6691.0040.77 A ATOM 3173 CB PRO A402 -39.359-12.229-56.8891.0040.32 A

ATOM 3174 CG PRO A 402 -37.883-12.409-56.762 1.0039.62 A

ATOM 3-175 -C PRO A 402 -41.291-13.574-55.9281.0042.35 A

ATOM 3176 O PROA 402 -42.317-12.973-55.6101.0042.08 A

ATOM 3177 N ALA A 403 -41.313-14.768-56.5141.0044.09 A ATOM 3178 CA ALA A 403 -42.571-15.438-56.801 1.0045.34 A

ATOM 3179 CB AXA A 403 -42.336 -16.653 -57.689 l.OO^'46.00 A

ATOM- 3180 C ALAA-403 -43-227 -15.8e5-55.5001.0O 46.02 A

ATOM 3181 O ALAA403 -44.440-- 15.744 -553461-GO 46.35 A

ATOM 3.1-82 N HIS-A_4Θ4 -42.428-16.359-54:561 1.004734 A ATOM 3183 CA HIS A 404 -42.956 -16.798-_^53.273- 1.004Sτ51 A

ATOM 3184 CB ffiS-A 404. -4k917 -T7.622 -5Z5101.0047.98 A

ATOM 31-85 CG -HI-S-A 4Q4 -42.453-18.268-51.2701.0047.58- A

ATOM 3186 CD2 HIS A 404 -42.403-17.885-49.972 1.0048.35 A

ATOM 3-187 NDl HIS A 404 -43.142-19.461-51.294 1.00-47.43 A ATOM 3188 CEl HIS A 404 -43.494-19.786-50.060 1.0047.17 A

ATOM 3189 NE2 HIS A 404 -43.057-18.846-49.241 1.0048.26 A

ATOM 3190 C HIS A 404 -43.421-15.620-52.423 1.0049.15 A

ATOM 3191 O HIS A 404 -44.490-15.666-51.815 1.0049.82 A

ATOM 3192 N LEU A 405 -42.612-14.567-52384 1.0049.09 A ATOM 3193 CA LEU A 405 -42.931-13.386-51.5901.0048.81 A

ATOM 3194 CB LEUA 405 -41.879-12.295-51.803 1.0047.87 A

ATOM 3195 CG LEU A 405 -40.477-12.590-51.2671.0046.76 A ATOM 3196 CDl LEU A 405 -39.578-11.372-51.418 1.0045.74 A ATOM 3197 CD2 LEU A 405 -40=538 -13.039 -49.8H 1.0044.69 A

ATOM 3T98 C LEU A 405 -44.317-12.851-51.933 1.0049.57 A

ATOM 31990 LEU A 405 -45.057-12.408-51.055 1.0049.79 A

ATOM 3200 N HIS A 406 -44.661-12.895-53.2161.0049.82 A

ATOM 3201 CA HIS A 406 -45.953-12.406-53.681 1.0048.66 A ATOM 3202 CB HIS A 406 -45.971-12.312-55.208 1.0048.91 A

ATOM 3203 CG HIS A 406 -47.241 -11.748 -55.765 LOO 50.76 A

ATOM 3204 CD2 HIS A 406 -47.471-10.652-56.5271.0050.86 A

ATOM 3205 NDl HIS A 406 -48.471-12.333-55.553 1.0052.42 A

ATOM 3206 CEl HIS A 406 -49.4.04-11.621-56.159 1.0052.24 A ATOM 3207 NE2 HIS A 406 -48.824-10.596-56.758 1,0051.03 A

ATOM 3208 C HIS A 406 -47,088-13.303-53.1981.00-48.17 A

ATOM 3209 O HIS A 406 -48.176 -12.S25 -52.8761.0048.24 A

ATOM 3210 N ALA A 407 -46.803-14.570-53.155 1.0047.55 A

ATOM 3211 CA ALA A 407 -47.778-15.544-52.8491.0047.09 A ATOM 3212 CB ALA A 407 -47.175-16.843-52.913 1.0045.58 A

ATOM 3213 C .ALA A 407 -48.231-15.287-31.4921.0047.12 A

ATOM 32140 ALAA-407 -49.247 -1-5.777 SIMS^' 1.0048.12 A

-AEOM- 3215 N ILEA 40fc -47.472-14.502-50.7691.0045.69 A

ATOM 32±6 CA ILE A 408 -47:619-14.3-81~49÷3i5:6- L.Θ.0--44.43 A - ATOM 3217 CB ELE A 408 -46.788 -15.239 -48.621 LO-O 43.09- A

ATOM 3218 CG2TLEA408 -45.856 -15.842 -49.486 LQO 42.85 A

ATOM 3219^GlILE A 408 -45.985-14.416-4-7.723 1.00^.20 A

ATOM 3220 CDl BLE A 408 -44.720-14.866-47.743 1.0039.90 A

ATOM 3221 C ILE A 408 -47.529-13.065-48.762 1.0043.91 A ATOM 3222 O ILE A 408 -47.701-12.895-47.6121.0044.14 A

ATOM 3223 N GLY A 409 -47.238-12.100-49.551 1.0043.79 A

ATOM 3224 CA GLY A 409 -47.990-10.922-49.425 1.0044.50 A

ATOM 3225 C GLY A 409 -47.088 -9.774-49.4381.0045.74 A

ATOM 3226 O GLY A 409 -47.515 -8.698-49.2881.0045.92 A , _B1

181

ATOM 3227 N LEU A 410 -45.827 -9.951-49.621 1.0046.73 A

ATOM 3228 CA LEU A 410 -45.112 -8.763-49.5181.0048.68 A

ATOM 3229 CB LEU A 410 -44.218 -8.769-48.3461.0048.91 A

ATOM 3230 CG LEU A 410 -43.682 -10.023 -47.758 LOO 48.12 A ATOM 323=1 CDl LEU A 410 -42.242 -9.906-47.7551.0048:34 A

ATOM 3232 CD2LEUA410 -44.092 -9.912-46.445 1.0047.14 A

ATOM 3233 C LEU A 410 -44.429 -8.247-50.695 1.0050.39 A

ATOM 3234 O LEU A 410 -43.682 -7.330-50.5991.0050.07 A

ATOM 3235 N EEU A411 -44.689 -8.82(6-51.8361.0052.00 A ATOM 3236 CA LEU A 411 -44.150 -8.292 -53.033 LOO 53.63 A

ATOM 3237 CB LEU A 411 -43.240 -9τ257 -53.6691.0053.77 A

ATOM 3238 CG LEUA 411 -41.880 -8.727-53.9501.0054.20 A-

ATOM 3239 CDl LEU A 411 -41.193 -9.481-54.990 1.0054.49 A

ATOM 3240 CD2 LEUA 411 -42.082 -7.444-54.409 1.0054.05. A ATOM- 3241 C EEU A 411 -45.253 -8.047-53.93-21.0055.43 A

ATOM 3242 O LEU A 411 -45.773 -8.911-54.5221.0056.12 A

ATOM 3243 N ALA A 412 -45.617 -6.810-53.9941.0057.46 A

ATOM 3244 CA ALA A 412 -46.861 -6.343-54.5951.0059.06 A

ATOM 3245 CB ALA A 412 -47.020 -4.845-54.3861.0057.79 A ATOM 3246 C ALA A 412 -46.919 -6.685-56.0801.0060.36 A

ATOM 32470 ALAA 412 -47^943 -6.483,-56.733 1.0060.73 A-

ATOM 3248 N ALAA-413 -45.845 -7.204-56.6061.0DJ63.14 A

ATOM 3249 CA ALA A 413 -45.596 -7.238-58.0471.0065.57 A

ATOM 3250 CB ALA A 413 -44.249 -6^623-58.393 1-.ΘΘ64.5_Θ A ATOM- 3251 C ALA-A 413 -45.687 -8.663 -58.584 1.0067.19 A

ATOM 3252 O ALAA4B^" -43:907 -9τ608 -5778271.00-68.89 A

ATOM .3253 N- ALA A 414 -45.514-8:808-59.893 1.00-68.04 A ATOM 3254 CA ALA A 414- -44.461 -9.656-60.438 LOO 68.43 A

ATOM 3255 CB ALA A-414 -44.977-11.070-60.655 1.0067.74 A ATOM 3256 C ALA A 414 -43.909 -9.083 -61.739 LOO 68.56 A

ATOM 3257 O ALA A 414 -44.663 -8.770-62.6601.0070.23 A

ATOM 3258 N ALA A 415 -42.589 -8.947-61.8071.0067.29 A

ATOM 3259 CA ALA A 415 -41.924 -8.521-63.033 1.0065.61 A

ATOM 3260 CB ALA A 415 -41.123 -7.252-62.7891.0065.25 A ATOM 3261 C ALA A 415 -41.025 -9.623-63.5841.0064.49 A

ATOM 32620 ALAA415 -39.840 -9.692-63.2561.0066.13 A

ATOM 3263 N ALAA416 -41.596-10.483-64.421 1.0061.83 A

ATOM 3264 CA ALA A 416^" -40.875-11.638-64.9421.0059.70 A ATOM 3265^~CB ALAA-4-16 -4 L850-12.729 -65355 1.0059.64 A

ATOM 3266 C ALA A 416 -39.982-11,248-66.115 1:0058.20 A

ATOM 32670 ALAA416 -40.388-11.338-67.2741.0058.88 A

ATOM 3268 N ASP A 417 -38.764-10.814-65.8071.0055.91 A

ATOM 3269 CA ASP A 417^" -37.804 ~10.42T-66.8381.0053.90 A ATOM 3270 CB ASP A 417 -37.966 -8.952-67.1391.0053.38 A

ATOM 3271 CG ASP A 417 -37.997 -8.135 -65.-8S6 l\0053.91 A

ATOM 3272. ODl ASPA 417 -39.050 -8.150 -65.195 L0Θ 54.73 A

ATOM 3273 OD2ASPA417 -36.960 -7.507-65.5801.0054.90 A

ATOM 3274 C ASP A 417 -36.387-10.659-66.321 1.0053.34 A ATOM 3275 O ASP A 417 -36.203 -11.159-65.2071.0054.14 A

ATOM 3276 N THRA 418 -35.390-10.292-67,1261.0051.46 A

ATOM 3277 CA THR A 418 -33,998-10.480-66.7321.0049.15 A

ATOM 3278 CB THRA 418 -33.029-10.367-67.938 1.0047.43 A

ATOM 3279 OGl THR A 418 -33.309 -9.166 -68.6641.0048.09 A ATOM 3280 CG2 THRA 418 -33.170-11.559-68.861 1.0047.09 A.

ATOM 3281 C THR A 41« -33.588 -9.465 -65.678 1.0048.82 A

ATOM 3282 O THR A 418 -337194 -9.840-64.575 1.0048.64 A

ATOM 3283- N -GLU A 419 -33.689 -8.183-66.014 J,00-48τ45 A

ATOM^" 3284 CA GLU-A-419 -33.306 -7.126 --65.0871.0047.51 A ATOM 3285 CB GLU A 419^" -33:871 -5.777 -653491.0048.99 A

ATOM 3286 GG GLU A 41P- -33.042 -5.123 -66τ65θ LOO 51.51 A

ATOM- 3287 CD -GLU A419- -33.45L -3.684 -66.9261.0054.24 A

ATOM 3288 OEl GLU A 419 -34.131 -J.079 -66.0641.0055.87 A

ATOM 3289 OE2 GLU A 419 -33.080 -3.152-67.9971.0055.58 A ATOM 3290 C GLU A 419 -33.725 -7.426-63.649 1.0045.73 A

ATOM 3291 O GLU A 419 -32.907 -7.382-62.7361.0044.88 A

ATOM 3292 N SER A 420 -34.995 -7.739-63.4401.0044.44 A

ATOM 3293 CA SER A 420 -35.446 -8.051-62.0971.0043.27 A

ATOM 3294 CB SER A 420 -36.963 -8.244-62.078 1.0043.75 A , „

183

ATOM 3295 OG SER A 420 -37.629 -7.024-62.3601.0043.55 A

ATOM 3296 C SER A 420 -34.736 -9.325-61.643 1.0042.24 A

ATOM 32970 SER A 420 -34.327 -9.441-60.493 1.0042.70 A

ATOM 3298 N ASP A 421 -34.577-10.267-62.5661.004L02 A ATOM 3299 CA ASP A 421 -33.921 -11.532 -62.2771.0(T4(L29 A

ATOM 3300 CB ASP A 421 -33.92S -12.412 -63.5371.0043.85 -A

ATOM 3301 CG ASP A 421 -33.562-13.867-63.2491.0047.18 A

ATOM 3302 ODl ASP A 421 -34.019-14.402-62.2101.0049.21 A

ATOM 33O3 OD2ASPA421 -32.830 -14.482 -64.0691.00-48.36 A ATOM 3304 C ASP A 421 -32.496 -11.286 -6L778 1.0038.50 A

ATOM 3305 O ASP A 421 -32.072-11:886-60.791 LOO 38.87 A

ATOM 3306 N ILEA422_ -3-1.759-10.408 -62.456- 1.0035.45 A

ATOM 3307 CA ELE A 422 -30.389-10.066-62.0501.0032.47 A

ATOM 3308 CB ILE A 422 -29.726 -9,052-63.065 1.00-31.16 A ATOM 3-309 CG2ILEA422 -28.496 -8.388-62.4-571.0029.04 A

ATOM 3310 CGl ILE A 422 -29.326 -9.772 -64.352 LOO 27.41 A

ATOM 3311 CDl ILE A 422 -28.151-10.677-64.201 1.0026.09 A

ATOM 33.12 C ILE A 422 -30.412 -9.449-60.6401.0031.94 A

ATOM 3313 O ELEA422 -29.665 -9.884-59.768 1.0032.22 A ATOM 3314 N ASN A 423 -31.268 -8.445-60.422 1.0030.22 A

ATOM 3315 CA ASN A 423 -31395 -7.796 -59rlT3- LOJO 27.60 A

ATOM 331-6- CB ASN A 423 -32.623 -6,882-59.0561.Θ0-26. F5 A

ATΘM 3317 CG ASN A 423 -32.411 -5.552-59.7621700-24.67 A

ATOM 3318 QDl ASN A-423 -31.528 -4.775 -59.-414 IAQT2A.01 A ATΘM 3319^" ND2 ASN A 423 -33.235 -5.285-60.755 1.00-2-6.39 A

ATOM 3320-e ASN A 423 -31.537 -8,845 -58.026 LOO 27.25 A

ATOM^" 3321 O ASN A 423 -30.765^~-8.86O -57.07617W27.L6 A

ATOM^" 3322 N TYRA 424 -32.537 -9.712-58.1641.0027702 A

ATOM 3323 CA TYR A 424 -32.759 -10J772 -57.191 1.-0029.02 A ATOM 3324 CB TYR A 424 -33.839 -11.753 -57.66T 1.0029.19 A

ATOM 3325 CG TYR A 424 -33.965-12.996-56.7961.0029.82 A

ATOM 3326 CDl TYR A 424 -34.273-12.900-55.431 LOO 30.39 A

ATOM 3327 CEl TYR A 424 -34.339-14.045-54.6141.0030.56 A

ATOM 3328 CD2TYRA424 -33.732-14.266-57.3241.0030.81 A _lg

ATOM 3329 CE2 TYR A 424 -33.795-15.411-56.521 1.0031.64 A

ATOM 3330 CZ TYRA 424 -34.097-15.296-55.169 1.0031.87 A

ATOM 3331 OH TYR A 424 -34.146-16.434-54.383 1.0030.68 A

ATOM 3332 C TYR A 424 -31.469-11.541-56.9291.0030.18 A ATOM 3333 O TYRA424 -31.005-11.627-55.785 1.0031.16 A

ATOM 3334 N LEU A 425 -30.892-12.103-57.9861.0029.73 A

ATOM 3335 CA LEU A 425 -29.661-12.867-57.852 1.0028.67 A

ATOM 3336 CB LEU A 425 -29.203-13.396-59.2161.0028.70 A

ATOM 3337 CG LEU A 425 -29.818-14.711-59.683 1.0026.91 A ATOM 3338 CDl LEU A 425 -29.093-15.196-60.9291.0028.16 A

ATOM 3339 CD2 LEU A 425 -29.693-15.739-58.5771.0027.02 A^~

ATOM 3340 C LEU A 425 -28.530-12.081-57.1921.0028.01 A

ATOM 3341 O LEU A 425 -27.731-12.654-56.4491.0027.72 A

ATOM 3342 N LEU A 426 -28.443-10.780-57.4621.0026.90 A ATOM 3343 CA LEU A 426 -27.392 -9.995-56.8341.0026.80 A

ATOM 33.44 CB LEU A 426 -27.280 -8.594-57.4341.0023.93 A

ATOM 3345 CG LEU A 426 -26.255 -7.783-56.6341.0022.44 A

ATOM 3346 CDl LEU A 426 -24.859 -8.146-57.0671.0021.13 A

ATOM 3347 CD2 LEU A 426 -26.486 -6.317-56.822 1.0022.57 A ATOM 334-8 C LEU A 426 -27.698 -9.880-55.3431.0027.65 A

ATOM 33490 LEU A 426 -26.813-10.047-54.508 1.0027.73 A

ATOM 3350 N LYS A 427 -28.953 -9,605 -55.003 IJ)B 29.51 A

ATOM 3351 CA LYS_A 427 -29.315 -9.495-53.595 1.-0030.79 A

ATOM 3352 CB LYS A 427 -30,822 -9-29^-53.407- 1.003T.88 A ATOM 3353 CG LYS_A_427 -3L125 -8.564-52.111 l.θθ 33.97 A

ATOMr 3354 CD LYS A 427 -32.565 -8.6^4-51.676 1.Θ&36.42 A-

ATOM 3355 CE LYS A 427 -32T721 -O95-50.272 1.0038.43 A

ATOM 3356 NZ LYS A 427 -3079 -8.808-49.261 1.0038:08 A

ATOM 3357 C LYS A 427 -28.874-10.764-52.873 1.0030.16 A ATOM 3358 O LYS A 427 -28.168-10.689-51.863 1.0029.92^~ A

ATOM 3359 N MET A 428 -29.284-11.923-53.393 1.0029.18 A

ATOM 3360 CA MET A 428 -28.899-13.206-52.8071.0029.18 A

ATOM 3361 CB MET A 428 -29.530-14.361-53.584 1.0028.83 A

ATOM 3362 CG MET A 428 -31.039-14.459-53.461 1.0030.84 A , _«

185

ATOM 3363 SD MET A 428 -31.605-14.982-51.840 1.0030.63 A

ATOM 3364 CE MET A 428 -31.200-16.689-51.913 1.0031.50 A

ATOM 3365 C MET A 428 -27.376-13.388-52.7971.0029.60 A

ATOM 33660 MET A 428 -26.837-14.088-51.9471.0029.55 A ATOM 3367 N ALA A 429 -26.687-12.762-53.748 1.0029.39 A

ATOM 3368 CA ALA A 429 -25.235-12.861-53.835 1.0027.95 A

ATOM 3369 CB ALA A 429 -24.757-12.285-55.158 1.0026.44 A

ATOM 3370 C ALA A 429 -24.603-12.102-52.6741.0028.08 A

ATOM 3371 O ALA A 429 -23.583 -12.520-52.1171.0027JΩ A ATOM 3372 N LEU A 43^"O -25.217-10.979-52.318 1.0027.70 A

ATOM 3373 CA LEU A 430 -24.734-10.154-51.2271.00.27.41 A

ATOM 3374 CB XEU A 4-30 -25.547 -8.864-51.1391.0025.13 A

ATOM 3375 CG LEU A 430 -25.372 -7.807-52.223 1.0022.90 A

ATOM 3376 CDl LEU A 430 -26.216 -6.595-51.873 1.0021.30 A ATOM 3377 CD2 LEU A 430 -23.914 -7.416-523301.0022.15 A

ATOM 3378 C LEUA430 -24.842-10.906-49.9091.0028.84 A

ATOM 3379 O LEU A 430 -24.0J5 -10.695 -49.006 1.0025.53 A

ATOM 3380 N GLU A 431 -25.843-11.780-49.8091.0030.41 A

ATOM -3381 CA GLU A 431 -26.075-12.575-48.600 1.0032.53 A ATOM 3382 CB GLUA 431 -27.557-12.948-48.464 1.0034.07 A

ATOM 3383 CG GLU A 431 -27.849-13.840-47.250 1.0038.11 A

ATOM 3384 CD GLU A 43-1 -29.347-14.056-46.9971.0040.47 A

ATOM 3385 OEl GLU A 431 -3JQ.135~13.105 -47-244 l.θθ 40.48 A

ATOM_3386 OE2 GLU A 431 -29.731-15.-166-46.5341.0041.87 A- ATOM .3387 C GLU A 431 _^25.25 &- 13.860-48:112 1.00-32,79- A

ATOM 338S O GLUA 431 -24.610-14.115^47300.1.0034.98 A

ATOM 3389 N LYS A 432 -25.281-14.668-49.5651.0032.4O- A

ATOM 3390 CA LYS^A 432 -24.564 -15.939 -49.5621.003O.94 A

ATOM 3391 CB LYS A 432 -25.350-16.984-50.372 1.0031.16 A ATOM 3392 CG LYS A 432 -26.856-17.105-50.041 1.0032.62 A

ATOM 3393 CD LYS A 432 -27.144-17.685-48.6601.0034.17 A

ATOM 3394 CE LYS A 432 -28.650-17.888-48.4471.0035.49 A

ATOM 3395 NZ LYS A 432 -29.009-18.228-47.0271.0035.42 A

ATOM 3396 C LYS A 432 -23.122-15.907-50.0661.0029.30 A ATOM 33970 LYS A 432 -22.249-16.523-49.4771.0030.16 A

ATOM 3398 N ILE A 433 -22.860-15.200-51.1521.0028.39 A

ATOM 3399 CA ILE A 433 -21.507-15.170-51.6961.0027.71 A

ATOM 3400 CB ELE A 433 -21.472-14.510-53.0981.0027.80 A ATOM 3401 CG2ELEA433 =20.043-14.525-53.650 LOO 27.34 A

ATOM 3402 CGl ELE A 433 -22.422-15.236-54.0491.0026.64 A

ATOM 3403 CDl ELE A 433 -22.099-16.684-54.250 1.0024.29 A

ATOM 3404 C ELE A 433 -20.539-14.412-50.803 1.0027.67 A

ATOM 3405 O ELE A 433 -19.449-14.892-50.4981.0028.26 A ATOM 3406 N ALA A 434 -20.946-13.214-50.4011.0027.14 A

ATOM 3407 -CA ALA A 434 -20.117-12.351-49.565 1.0025.55 A

ATOM 34Q8 CB ALA A 434 -20.862 -11.034 -49.269- 1.0024.31- A

ATOM 3409 C ALA A 434 -19.694-13.007-48.263 1.0024.09 A

ATOM 3410 O ALA A 434 -18.204-12.604-47.6571.0025.45 A ATOM 3411 N PHE A 435 -20.440-14.020-47.842 1,002238 A

ATOM 3412 CA PHEA 4J5 -20.175 -14.711 -46.593 1.0021.70_ A

ATOM 3413 CB PHE A 435 -21.469-15.354-46.085 1.0022.37 A

ATOM 3414 CG PHE A 435 -21.334-16.029-44.7521.0024.26 A

ATOM 3415 CDl PHE A 435 -2L473 -15.304 -43.5701.0026.04 A ATOM 3416 CD2PHEA435 -21.036-17.394-44.675 1.0024.68 A

ATOM 3417 CEl PHE A-435 -21.314 -15.93U -42.3161.0027.05 A

ATOM 3418 CE2 PHEA 435 -20.875-18:032-43.443 1.0025.53 A

ATOM 34=19 CZ PHE A 435 -21D14 -17.295 -42.252 1.0027.0.1 A

ATOM- 3420 G PHE A 435 -49M9 -15.770 -46.710 1.0020.54 A ATOM 3421 O PHE A 435 -18J278 -15.945 -45.803 L-O0L21.12 A

ATOM 3422 N LEUA 436 -1-9.071 -16.474-47.8321.002028 A

ATOM- 3423 CA LEU A 436 -18.108 -17:544-48.0571.0019.96 A

ATOM 3424 CB LEU A 436 -18.047-17.871 -4SL545 1.0021.67 A

ATOM 3425 CG LEU A 436 -19.382-18.370-50.068 1.0022.94- A ATOM 3426 CDl LEU A 436 -19.192-18.883-51.4841.0025.86 A

ATOM 3427 CD2 LEU A 436 -19.908-19.471-49.1661.0021.18 A

ATOM 3428 C LEU A 436 -16.701-17.291-47.5271.0018.76 A

ATOM 3429 O LEU A 436 -16.159 -18.103 -46.7641.001627 A

ATOM 3430 N PRO A 437 -16.079-16.172-47.932 1.0017.95 A , ₇

17

ATOM 3431 CD PRO A 437 -16.517-14.990-48.6981.0015.22 A

ATOM 3432 CA PRO A 437 -14.735-15.984-47.3901.0018.02 A

ATOM 3433 CB PRO A 437 -14.329-14.609-47.948 1.0016.08 A

ATOM 3^"434 CG PRO A 437 -15.63-8 -13.907 -48.135 1.0014.85 A - ATOM 3435 C PRO A 437 -Ϊ4.736 -16.070 -45.8461.0018.39 A

ATOM 3436 O PRO A 437^" -14.114-16.964-45.279 1.0017.93 A

ATOM 3437 N PHE A 438 -15.462-15.167-45.1871.0018.36 A

ATOM 3438 CA PHE A 438 -15.548-15.133-43.7291.0020.27 A

ATOM 3439 CB PHEA 433 -16.668-14.185-43.2971.0020.49 A ATOM 3440 CG PHE A 438 -16.686-13.902-41.818 1.0022.05 A

ATOM 34^~41 CDlPHE A 438 -15.652-13.188-41.221 1.0022.96 A

ATOM 3442 CD2PHEA438 -17.739-14.349-41.023 1.0022.Sl A

ATOM 3443 CEl PHE A 438 -15.667-12.920-39.8571.0025.14 A

ATOM 3444 CE2PHEA438 -17.767-14.086-39.6501.0024.16 A ATOM 3445 CZ PHE A 438 -16.728-13.369-39.0661.0024.8J A

ATOM 3446 C PHE A 438 -15.785-16.51-0-43.099 1.0020.79 A

ATOM 3447 O PHE A 438 -15.004-16.964-42.261 1.OO20.02 A

ATOM 3448 N GLYA 439 -16.872-17.165-43.490 1.0021.12 A

ATOM 3449 CA GLY A 439 -17.163-18.478-42.9491.0021.27 A ATOM 3450 C GLY A 439 -15.950-19.398 -42.9671.OJO 23.22 A

ATOM 3451 O GLY A 439 -15.722 -20.169" -42.033 1.00^{^}26.53 A

ATOM^" 3452 N TYRA.440 -15.164-19325-44.033 1.0022.35 A

ATOM 3453 -CA TYR A 440 -13.974-20.155-44.175 1.0021.52 A

ATOM 3454 CB TYdStA 440 -13.423 -1-9:99:8.-45.5941.002CL29- A- - ATOM 3455 CG TYR^~A 440 -12311 -20.952-45.925 1.00-17.52 A

ATOM 3456- CDl TYR A-440 -1-2.555 -22.316 -46.0171.0Θ-Ϊ7.12 -A

ATOM 3457 CEl TYR-A-440 -11.534 -23:211 -46.31-6 LOO-16.95 A

ATOM 3458-CD2TYRA440 -11.015 -20.494--46.1371.0016.21 A

ATOM 3459 CE2TYRA440 -9.983-21.378-46.4341.0016.47 A ATOM 3460 CZ TYR A 440 -10.250-22.739-46.523 1.0016.21 A

ATOM 3461 OH TYR A 440 -9.249-23.639-46.811 1.0012.39 A

ATOM 3462 C TYR A 440 -12.914-19.721-43.163 1.0022.02 A

ATOM 3463 O TYR A 440 -12.441-20.503-42.341 1.0022.67 A

ATOM 3464 N LEU A 441 -12.564-18.447-43.2561.0021.90 A _{λ 8S}

188

ATOM 3465 CA LEU A 441 -11.565-17.775-42.435 1.0021.58 A

ATOM 3466 CB LEU A 441 -11.641-1-6.284-42.7671.0022.89 A

ATOM 3467 CG LEU A 441 -11.317-15.166-41.769 1.0024.57 A

ATOM 3468 CDl LEU A 441 -11.375-13.869-42.5521.0027.81 A ATOM 3469-CD2JLEUA441 -12301 -15.091 -40.618 1.0023.70 A

ATOM 3470 C LEUA-441 -117577-17.962-40.9061.0021.14 A

ATOM 3471 O LEU A 441 -10.539-18.244-40.301 1.0020.90 A

ATOM 3472 N VAL A 442 -12.740-17.795-40.283 1.0019.63 A

ATOM 3473 CA VAL A 442^' -12.846-17.887-38.833 1.0018.48 A ATOM 3474 CB VAL A 442 -14.314-17.749-38.3851.0016,57 A

ATOM 3475 CGl VAL A 442 -14.432 -18.127 -36.923 1.0015.46 A

ATOM 34.76 CG2 VAL A 442 -14.780 -16.307 -385991.0014.72 A

ATOM 3477 C VALA442 -12.213-19.117-38.1881.0019.80 A

ATOM 3478 O VALA442 -11.294-18.988-37.3681.0019.92 A ATOM 3479 N- ASP A 443 -12M1 -20.305 -38.5371.0020.90 A

ATOM 3480 CA ASP A 443- -12.110-21.494 -37.9441.0021.62 A

ATOM 3481 CB ASP A 443 -13.021-22.689-38.1591.0022.30 A

ATOM 3482 CG ASP A 443 -13.945 -22.930 -36.980 LOO 22.13 A

ATOM 3483 ODl ASP A 443 -14.328-21.951-36.2981.0018.75 A ATOM 3484 OD2ASPA443 -14.287-24.110-36.7471.0023.90 A

ATOM- 3485 G ASP A 443^" -10.727-21.746-38.505 IJOO 22.11 A

ATOM 3486 σ ASP A 443 -9.995 -22.603 -38.0L9 LOO 22.3-7 A 3487--N GLN A 444 - 10.37.5.-20.996 -39.542 1.0023.37 A

ATOM 3488 CA^GLN A 444 -9.Q42 -21.089 -40JL18-1.0024.45 A- ATOM 3489--CB GLN A 444 -8:935- -20.215. -41.3741.0027.22 A

ATOM- 34PO-CG GLN A 444 -9:5-81-20.796- 42.6-161.0031.23 A

ATOM 3491-CD GLN-A 444 -8-:94S -22.120-42:998" 1.0034.10 A-

ATOM 3492 OE-I- GLN A 444 -7.725 -22.203 -43.1991.0036.11 A

ATOM 3493 NE2 GLN A 444 -9.772 -23.168 -43.0921.0033.25 A ATOM 3494 C GLN A 444 -8.146-20.504-39.0271.0023.80 A

ATOM 3495 O GLN A 444 -7.129-21.084-38.636 1.0022.44 A

ATOM 3496 N TRP A 445 -8.557-19.336-38.5401.0023.38 A

ATOM 3497 CA TRP A 445 -7.850-18.623-37.493 1.0023.09 A

ATOM 3498 CB TRP A 445 -8.567-17.307-37.185 1.0022.16 A _m

ATOM 3499 CG TRP A 445 -7.989-16.574-36.0041.0022.85 A

ATOM 3500 CD2 TRP A 445 -8.513-16.544-34.658 1.0023.14 A

ATOM 3501 CE2TRPA445 -7.630-15.762-33.884 1.0022.08 A

ATOM 3502 CE3 TRP A 445 -9.640-17.104-34.0361.0022.69 A ATOM 3503 CDl TRP A 445 -6_*848-1-5:831 -35^984 1.0022:23 A

ATOM 3504 NEl TRFA 445 -6.626-15.340-34.7141.0022.96 A

ATOM 3505 CZ2TRPA445 -7.836-15.522-32.521 1.0020.49 A

ATOM 3506 CZ3 TRP A 445 -9.846-16.866-32.6791.0021.70 A

ATOM 3507 CH2 TRP A 445 -8.948 -16.082 -31.937^" ITOO 20.61 A ATOM 3508 C TRP A 445 -7.788-19.463-36.223 1.0023.41 A

ATΘM 3509 O TRP A 445 -6.7H) -19.633 -35.6341.002433 A

ATOM 3510 N ARGA446 -8,943-19.987-35.813 LOO 21.70 A

ATOM 3511 CA ARG A 446 -9.036-20.779-34.5921.0020.79 A

ATOM 3512 CB ARG A 446 -10.490-2-1.064-34.230 1.0021.22 A ATOM 3513 CG ARG A 446 -10.929-20.327-33.005 1.0021.94 A

ATOM 3514 CD ARGA 446 -12.220-20.853 -32.456 1.0O 23.12 A

ATOM 3515 NE ARG A 446 -13.324-20.718-33.3961.0025.87 A

ATOM 3516 CZ ARG A 446 -14.598-20.602-33.025 1.0028.25 A

ATOM 3517 NHl ARG A 446 -14.923-20.602-31.731 1.0031.49 A ATOM 3518 NH2 ARG A 446 -15.550-20.489-33.9361.0028.83 A

ATOM 3519 C ARGA446 -8.276.-22.083-34.5461.00-21.40 A

ATOM 3520 O ARG A 446 -7.632 -22357 -33.5471.0021.39 A

ATOM 3521 N TRP A 447 -8.350 -22τ«98 -35.5951.0021.41 A

ATOM 3522 CA- TRP A 447 -7,629-247167-35.561 1.0021.71 A - ATOM 3523 GB TRP A 447 -7.742-24:934-36.891 1.0024.23 A

ATOM 3524- CG TRP A-447 -9τl 11 -25.409-37.2421.0025τO9" A

ATOM 3525 CD2 TRPA 447 -9.606 -25.669 J8L5541.0026 Al A

ATOM 3526 CE2 TRP A 447 -10.948-26.090-38.421 1.0027.09 A

ATOM 3527 CE3 TRP A-447 -9.046-25.586-39.8361.0026,63 A ATOM 3528 CDl TRP A 447 -10.135-25.679-36.3861.0026.21 A

ATOM 3529 NEl TRP A 447 -11.250-26.088-37.085 1.0027.08 A

ATOM 3530 CZ2TRPA447 -11.740-26.422-39.520 1.0027.29 A

ATOM 3531 CZ3TRPA447 -9.833-25.915-40.9291.0026.72 A

ATOM 3532 CH2TRPA447 -11.168-26.327-40.763 1.0027.26 A , _Qn

190

ATOM 3533 C TRP A 447 -6.167-23.899-35.276 1.0020.17 A

ATOM 3534 O TRP A 447 -5.471-24.736-34.703 1.0019.06 A

ATOM 3535 N GLY A 448 -5.719-22.720-35.688 1.0019.58 A

ATOM 3536 CA GLY A 448 -4.340-22.318-35.4941.0020.58 A ATOM 3537 C GLY A 448 -4,038-21.785-34.1041.0021.48- A-

ATOM 3538 O GLY A 448 -2.888-21.836-33.655 1.0021.72 A

ATOM 3539 N VAL A 449 -5.054-21.248-33.4301.0021.03 A

ATOM 3540 CA VAL A 449 -4.874 -20.754 -32.075 LOG 20.32 A

ATOM 3541 CB VAL A 449 -6.068-19.902-31.609 1.0021.00 A ATOM 3542 CGl VAL A 449 -5.955-19.631-30.115 1.00.21.02 A

ATOM 3543 CG2 VAL A 449 -6.1 IO -18.595 -32.376- 1.0019v62 A

ATOM 3544 C VAL A 449 -4.787-21.974 -3 L 1771.0019.42- A

ATOM 3545 O VAL A 449 -3.926-22.061-30.3141.0019.23 A

ATOM 3546 N PHE A 450 -5.701-22.908-31.403- 1.0019.35 A ATOM 3547 CA PHE A 450 -5.779-24.154-30.648 1.0020.25 A

ATGM 3548 CB PHE A 450 -6.993-24.984-31.0901.0020.48 A

ATOM 3549 CG PHE A 450 -8.288-24.573-30.4571.0020.63 A

ATOM 3550 CDl PHE A 450 -9.445-24.500-31.212 1.0021.06 A

ATOM 3551 CD2PHEA450 -8.365-24.301-29.098 1.0021.32 A ATOM 3552 CEl PHE A 450 -10.660-24.164-30.618 1.0021.58 A

ATOM 3553 CE2PHEA450 -9.580-23.9-64-28.503 1.0020=59 A

ATOM 3554- CZ PHE A-450 -10.721 -23.898-29.2621.0019.68 A

ATOM 3555 C PHE-A 450 -4346 -25J0Θ7-3OJ847 LOO 21.17 A'

ATOM : 3556 O- PHE A 4530 -4.212~25.823÷-29.989 1.00.21,95- A ATOM_3557 N SER-A-451 -3.875-24:841 -3L982 1.00.21.31 A-

AT-OM 3558 CA SER Aτ4S.I -2.689- -25.646 -32.259 l.OO^'22.22 A

ATOM 3559 CB- SER A 451 -2.649-26.060-33.7301.0022.35 A

ATOM 3560 OG SER A 451 -2.021 -25.074 -34.536- LOO 25.87 A

ATOM 3561 C SER A 451 -1.388-24.947-31.902 LQO 22.43 A ATOM 3562 O SERA 451 -0.333 -25.574 -3L8941.0023.31 A

ATOM 3563 N GLY A 452 -1.456-23.652-31.623 1.0022.54 A

ATOM 3564 CA GLY A 452 -0.251-22.929-31.266 1.0024.09 A

ATOM 3565 C GLY A 452 0.463-22.228-32.4021.0026.41 A

ATOM 35660 GLY A 452 1.543-21.686-32.201 1.0027.59 A ATOM 3567 N ARG A 453 -0.182-22.037-33.498 1.0028.87 A

ATOM 3568 CA ARG A 453 0.506-21.502-34.5991.0031.83 A

ATOM 3569 CB ARG A 453 0.004-22.197-35.8421.0034.80 A

ATOM 3570 CG ARG A 453 -0.023-21.387-37.1061.0039.04 A

ATOM 3571= CD ARG A 453 -1.380-21.323-37.7501.0042.67 A

ATOM 3572 NE ARG A 453^' -1.460-21.864-39.073 1.0047.08 A

ATOM 3573 CZ ARG A 453 -2.539-22.362-39.625 1.0047.43 A

ATOM 3574 NHl ARG A 453 -3.674-22.416-38.9771.0046.12 A

ATOM 3575 NH2ARGA433 -2.465 -22.771 -4O.8771.0047.15 A

ATOM 3576 C ARG A 453 0.163 -20.088 -34.5901.0031.42 A

ATOM 3577 O ARG A 453 0.751-19.262-35.2261.0031.97 A

ATOM 35-78 N THRA454 -0.817 -19:817 -33.793 1.0030.21 A

ATOM 3579 CA THR A 454 -1.213-18.453-33.4991.0030.22 A

ATOM 3580 CB THR A 454 -2.576-18.101-34-141 1.0031.51 A

ATOM 3581- OGL THRA 454 -2.502-18.244-35.3691.0032Jl A

ATOM 3582 CG2THRA454 -2.959-16.658-33.7921.0031.46 A

ATOM 3583 C THR A 454 4.309-18.234-31.985 1.0028.81 A

ATOM 3584 O THR A 454 -2.381 -18.394 -31 J931.0030.11 A

ATOM 3585 N PRO A 455 -0.179-17:891-31.3341.0026.25 A

ATOM 3586 CD PRO A 455 1.185 -17.833 -31.8921.0024.90 A

ATOM 3587 CA PRO A 455 -0.157-17.648-29.8891.0024.44 A

ATOM 3588 -CB PRO A 455 L329 -17.645 -29.571 1.0025.03 A

ATOM 3589 CG PRO A- 455 L936 -17.101 -30.822 LOΘ-23.84 A

ATOM 3590- C PRO-A 455 -0:812 -16.3-00-29.6081JQΘ 22.90 A

ATOM 3591- O PRGhA 455 -1,-032 -15.51-5 -30:520 LOO 22.71 A

ATOM 3592 N ^"PRO A 456_ -1.T3L-16.006 -28.344 bGΘ^~22.53 A

ATOM 3593 CD PRO A 456 -1.051 - 16-8TT -27.1T8^~ 1.0021.88 A

ATOM 3-594 CA PRO A 456 -1.763 -14.711-28.073 1.0022.90 A

ATOM 3595 CB PRO A 456 -1.946-14.743-26.5621.0021.95 A

ATOM 3596 CG PRO A 456 -2.126 -16.194 -26.2841.0020.73 A

ATOM 3597 C PRO A 456 -0.915-13.527-28.5501.0023.24 A

ATOM 3598 O PRO A 456 -1.393-12.396-28.6781.0022.92 A

ATOM 3599 N SERA 457 0.352-13.806-28.822 1.0022.64 A

ATOM 3600 CA SERA 457 1.263-12.780-29.275 1.0022.95 A ATOM 3601 CB SERA 457 2.713-13.262-29.1501.0023.24 A

ATOM 3602 OG SER A 457 3.032-14.239-30.125 1.0026.16 A

ATOM 3603 C SER A 457 0,963-12.382-30.713 1.0022.84 A

ATOM 3604 O SERA 457 1.475-11.366-31.186 1.0023.98 A ATOM 3605 N ARG A 458 0.140-13.184-31.398 1.0022.74 A

ATOM 3606 CA ARG A 458 -0.256-12.919-32.801 1.0022.56 A

ATOM 3607 CB ARG A 458 0.465-13.857-33.7791.0021.47 A

ATOM 3608 CG ARG A 458 1.976-13.767-33.7571.0020.43 A

ATOM 3609 CD ARG A 458 2.589-14.587-34.873 1.0019.60 A ATOM 3610 NE ARG A 458 3.838: -15.191 -34.445 1.0017.93 A

ATOM 3611 CZ ARG A 458. 4.002-16.489-34^291.0018.97^" A

ATOM 3612 NHl ARG A 45.8. 2.994-17.332-34.4041.0019.09 A

ATOM 3613 NH2ARGA458 5.177-16.945-33.834 1.0020.45 A

ATOM 3614 C ARG A 458 -1.758-13.062-33.047 LOO 21.81 A ATOM 3615 O ARGA-458 -2.187-13.262-34.175 1.0020.92 A

ATOM 3616 N TYR A 459 -2.551-12.955-31.991 1.0022.24 A

ATOM 3617 CA TYR A 459 -3.993-13.083-32.121 1.0022.70 A

ATOM 3618 CB- TYR A 459 -4.681-12.850-30.765 1.0024.47 A

ATOM 3619 CG TYR A 459 -4.814-14.075-29.8741.0024.77 A ATOM 3620 CDl TYR A 459 -5.664-14.062-28.768 1.0024.45 A

ATOM 3621 CEl TYR A 459 -5.790-15.168-27.937 1.0024.34 A

ATOM 3622 CD2ΪΥRA459 -4.09145.238-30.125 1.0026.41 A

ATOM 3623 CEZ TYR A 459 -4.213 -16.348- -29.298 T.0026J58 A

ATOM 3624 CZ JSRA 459 -5.064-16.355-28^041.Θ0Z5.83 A ATOM ^"3625 GH TYR A 459 -5.172 -17.4.04 -27-.375 b002&52 A

ATOML 3626 C TYR A 459 -4.578 -12.113 -33.143 lJ9022.65 A

ATOM- 3627 O TYRA 459- -5.332-12.521-34.028 LOG 22.41 A

ATOM 3628 N ASN A 460 -4.248-10.828-33.024 1.0021.50 A

ATOM 3629 CA ASN A 460 -4.804 -9.852-33.9501.0020.16 A ATOM 3630 CB ASN A 460 -4.844 -8.464-33.3181.0019.14 A

ATOM 3631 CG ASN A 460 -6.166 -7.756-33.5701.0019.69 A

ATOM 3632 ODl ASN A 460 -7.239 -8.321 -33.326 1.0018.65 A

ATOM 3633 ND2 ASN A 460 -6.100 -6.520-34.059 1.0019.97 A

ATOM 3634 C ASN A 460 -4.058 -9.798 -35.266 1.0019.78 A ATOM 3635 O ASN A 460 -4.660 -9.607-36.323 1.0021.02 A

ATOM 3636 N PHE A 461 -2.749 -9.981 -35.2101.0017.97 A

ATOM 3637 CA PHE A 461 -1.955 -9.954-36.4081.0015.62 A

ATOM 3638 CB PHE A 461 -0.495 -9.957-36.0321.0016.13 A

ATOM 3639 CG PHE A 461 0.425 -10351 -37.133 1.0016.86 A

ATOM 3640 CDl PHE A 461 0.837 -11.673 -37.2661.0017.09 A

ATOM 3641 CD2PHEA461 0.964 -9.397-37.978 1.0018.04 A

ATOM 3642 CEl PHE A 461 1.776-12.038-38.2101.0017.01 A

ATOM 3643 CE2PHEA461 1.912 -9.755 -38.9341.0Θ 18.08 A

ATOM 3644 CZ PHE A 461 2.321-11.074-39.049 1.0017.61 A

ATOM 3645 C PHE A 461 -2.296-11.117-37.306 LOO 16.41 A

ATOM 3646 O PHE A 461 -2.204-10.979-38.5121.0.019.34 A

ATOM 3647 N ASP A 462 -2.698-12.262-36.7551.0016.99 A

ATOM 3648 CA ASP A 462 -3.056-13.395-37.6241.0018.19 A

ATOM 3649 CB ASP A 462 -2.724-14.753-36.9771.0019.47 A

ATOM 3650 CG ASP A 462 -1.301-15.203-37.265 1.0020.73 A

ATOM 3651 ODl ASP A 462 -0.629-14.525-38.0641.0022.71 A

ATOM 3652 OD2ASPA462 -0.849-16.229-36.706 1.002137 A

ATOM 3653 C ASP A 462 -4.529-13355-38.035 1.0018.57 A

ATOM 3654 O ASP A 462 -4.939-14.029-38.9871.0018.85 A

ATOM 3655 N TRP A 463 -5321-12.562-37319 l.Oσ 17.77 A

ATOM 3656 CA TRP A 463 -6.734 -12.408- -37.6401. OD 16.92 A

ATOM 3657 CB TRP A 463 -7.486-11.829-36.4321.0014.22 A

ATOM. 3658 CG TRP A-463 -8.936-11.4UL-36.66S 1.0010.02 A

ATOM 3659 CD2TRPA463 -1O.092 -12.253 -36.7.11 1.009.24 A

ATOM -3660 CE2 TRP A463 -L1.224 -11.414 -36.833 1.008:76 A

ATOM 3661 CE3 TRP A-463 -10.281 -13τ645 -36.657 -1.009.71 A

ATOM 3662 CDl TRP A 463 -9.406-10.122-36.7701.009.37 A

ATOM 3663 NEl TRP A 463 -10.773 -10.121 -36.865 1.009.69 A

ATOM 3664 CZ2 TRP A 463 -12.526-11.914-36.8961.008.90 A

ATOM 3665 CZ3TRPA463 -11.577-14.145-36.7221.0010.56 A

ATOM 3666 CH2 TRP A 463 -12.684-13.277-36.8391.0011.27 A

ATOM 3667 C TRP A 463 -6.858 -11.490 -38.855 1.0017.54 A

ATOM 3668 O TRP A 463 -7.564-11.799-39.7961.0018.14 A _m

ATOM 3669 N TRPA 464 -6.165-10.360-38.8491.0019.35 A

ATOM 3670 CA TRP A 464 -6.255 -9.464-39.9981.0021.50 A

ATOM 3671 CB TRP A 464 -5.818 -8.050-39.6201.0022.37 A

ATOM 3672 CG TRP A 464 -6.867 -7.391-38.7991.0025.27 A ATOM 3673 CD2TRPA464 -8.082 -6.818-39.2871.0027.31 A

ATOM 3674 CE2TJRPA464 -8.-855 -6.457-38.161 1.0027.82 A

ATOM 3675 CE3TRPA464 -8.595 -6.577-40.571 1.0028.49 A

ATOM 3676 CDl TRP A 464 -6.944 -7.346-37.433 1.0025.51 A

ATOM 3677TsIEl TRP A 464 -8.136 -6.79Θ -37.043 1,0026.13 A ATOM 3678 CZ2TRPA464 -10.118 -5.867-38.278 1.0029.60 A

ATOM 3679 GZ3TRPA464 -9.851 -5.988-40.691 1.0029.45 A

ATOM 3680 CH2 TRPA 464 -10:598 -5.640 -39:548- 1.0030.76 A

ATOM 3681 C TRP A 464 -5.470 -9.988-41.199 1.0022.46 A

ATOM 3682 O- TRP A 464 -5.627 -9.504-42.328 1.0022,21 A - ATOM 31583 N TYR A 465 -4.613 -10.977-40.968 h0021.92 A

ATOM 3684 CA TYR A 465 -3.908-11.565-42.089 1.0020.47, A

ATOM 3685 CB TYRA465 -2.855-12.574-41.6281.0021.55 A

ATOM 3686 CG TYR A 465 -2.345-13.418-42.773 1.0023.60 A

ATOM 3687 CDl TYR A 465 -1.445 -1Z904 -43.7071.0023.50 A ATOM 3688 CEl TYR A 465 -1.045-13.653-44.819 1.0025.30 A

ATOM 3689 CD2 TYR A 465 -2.832-14.708-42.9791.0025.25 A

ATOM 3690 CE2 TYR A 465 -2.448 -15.458-44,089 1.0027.28 A

ATOM 3691 CZ TYJBLA-465 -1.555 -14.927 -45.-Θ061.0026.75 A

ATOM 3692 OH TYR A 465 -U98--15.671 -46.11-2 L00-27.23 A ^ ATOM 3693 -C TYR-A 465 -5.025 -12.300 -42.8391.0019.15 A

-ATOM 3694 O TYR A 465 -5.264 -12:078 -44:024- 1.0019..77 A

ATOM.3695 N L-EU A 466 -5.73fr-13.153 -42.1141.0016.19 A

ATOM 3696 CA LEU A- 466 -6.807-13.934-42.7061.0014.96 A

ATOM 3697 CB LEU A 466 -7.356 -14.937 -4L683 1.0012.13 A ATOM 3698 CG LEU A 466 -6.351-15.981-41208 1.0010.49 A

ATOM 3699 CDl LEU A 466 -7.035-16.923-40.2761.0011.32 A

ATOM 3700 CD2 LEU A 466 -5.790-16.751-42.3821.009.40 A

ATOM 3701 C LEU A 466 -7.941-13.117-43.2921.0015.16 A

ATOM 3702 O LEU A 466 -8.439-13.451-44.353 1.0016.26 A , _Q<

195

ATOM 3703 N ARG A 467 -8.344-12.053-42.6041.0016.10 A

ATOM 3704 CA ARG A 467 -9.444-11.194-43.058 1.0016.29 A

ATOM 3705 CB ARG A 467 -9.795-10.167-41.9801.0016.59 A

ATOM 3706 CG ARG A 467 -1-0.258-10.788-40.6741.0016.94 A ATOM 3707 CD ARGA Ml -14,777-10.847-40.5671.0019.18 A

ATOM 3708 NE ARGA 46.7 -112.389 -9.513^" -40:5951.0020.-42 A

ATOM 3709 CZ ARG A 467 -13.687 -9.268-40.433 1.0019.37 A

ATOM 3710 NHl ARG A 467 -14.127 -8.025-40.482 1.0019.86 A ATOM 3711 NH2 ARG A467 -14.544-10.258-40.211 1.0018.20- A ATOM 3712 C ARG A 467 -9.076-10.486-44.353 1.0017.10 A

ATOM 3713 O ARGA 467 -i>:831 -1-0.534 -4573271,0018.11 A

ATOM -3714 N THRA 468 -7.918 -9.832-44.3-741.0017.19 A

ATOM 3715 CA THR A 468 -7.486 -9.159-45.5901.0017.27 A

ATOM 3716 CB THRA-46.8 -6.098 -8.478-45.438 1.0016.69 A ATOM 3717 OGl THRA 468- -6.202 -7.317- -44.5941.0015.44 A

ATOM 3718 CG2THRA468 -5.565 -8.058-46.8061.0014.50 A

ATOM 3719 C THR A 468 -7.392-10.233-46.6671.0018.27 A

ATOM 3720 O THR A 468 -8.063-10.142-47.6991.0020.61 A

ATOM 3721 N LYS A 469 -6.585-11.262-46.403 1.0017.40 A ATOM 3722 CA LYS A 469 -6.392 -12.354 -47.3471.0015.93 A

ATOM 3723 CB- LYS A 469 -.5,616-13.505-46.705 1.0014.24 A

ATOM 3724 CG LYS A469 -5.509 -14:715 -47:625 l.OΘ 12.48 A

ATOM -3725- CD LYS A-469 -4.649 -15.828 -47.05-91.0011.60 A

ATOM 3726 CE_LYSA_tø£ -4.944-17.116-47.805 1.0012.05 A ATOM 3727 NZ LYS A469- -3.917-1-8.1:81-47.635 1.001338 A

ATOM 3728^~C LYS A-469 -7.647-12.923-47.975 1:00-16.31 A

ATOM- 3729 O LYS Aτ469 -7.688-13.124-49.170 1.00-18.59 A

ATOM 3730 N TYRA47Θ -8.676-13.196-47.1-92 1.0017.11 A

ATOM 3731 CA TYR A 470 -9.874-13.780-47.783 1.0018.71 A ATOM 3732 CB TYR A 470 -10.441 -14.897-46.894 LOO 17.17 A

ATOM 3733 CG TYR A 470 -9.572-16.132-46.8421.0017.88 A

ATOM 3734 CDl TYR A 470 -8.549-16.250-45.9051.0017.58 A

ATOM 3735 CEl TYR A 470 -7.721-17.365-45.8921.0018.02 A

ATOM 3736 CD2 TYR A 470 -9.744-17.170-47.7651.0016.98 A _1%

ATOM 3737 CE2 TYR A 470 -8.923-18.289-47.7571.0014.63 A

ATOM 3738 CZ TYRA 470 -7.916-18.381-46.821 1.0016.45 A

ATOM 3739 OH TYR A 470 -7.099-19.489-46.7941.0018.19 A

ATOM 3740 C TYRA 470 -10.986-12.803 -48. B2 1.0020.06 A ATOM 3741 O TYRA 470 -11.574-12.907-49=208 1.0022.-88 A

ATOM 3742 N GLNA 471 -11.281 -11,857-47.2491.0018791 A

ATOM 3743 CA GLN A 471 -12.348-10.917-47.545 1.0018.37 A

ATOM 3744 CB GLN A 471 -13.053-10.512-46.254 1.0019.72 A

ATOM 3745 CG GLN A 471 -14.005-11.593-45.753 1.0023.55 A ATOM 3746 CD GLN A 471 -14.758-11.204-44.495 1.0025.32 A

ATOM 3747 OEl GLN A 471 -14.180-11.125-43.4091.00^3.98 A

ATOM 3748 NE2 GLN A 471 -16.056-10.953-44.638 1.0026.86 A

ATOM 3749 C GLN A 471 -11.900 -9.678-48.3191.0017.38 A

ATOM 3750 O GLN A 471 -12.706 -9.039 -49τ003 LQO 15.73 A ATOM 3751 N GLY A 472 -10.615 -9.353-48.241 LOG 15.54 A

ATOM 3752 CA GLY A 472 -10.143 -8.175-48.930 1.0016.10 A

ATOM 3753 C GLY A 472 -10.736 -6.939-48.2841.00.16:73 A

ATOM 3754 O GLY A 472 -11252 -6.019-48.9351.0014.53 A

ATOM 3755 N ELE A 473 -10.681 -6.947-46.961 1.0018.68 A ATOM 3756 CA ILE A 473 -11.172 -5.842-46.1691.0018.10 A

ATOM 3757 CB DLE A 473 -12.436 -6.216-43-398,1.0017.35 A

ATOM 3758 CG2 BLE-A 473 -13.540 -6.551 -46.370 l.θθ 1-7.73 A

ATOM 3759 CGl ILE AA73 -12.15«— 7.402-44.478-1.001.7.91 A

AT-OM 376JD CDl ILEA 473^~ -13.266 -7.654-43.4271:0017.89 A ATOM- 3761 C DLE A 473 -10.078 -5.498 -45.IS6^~ 1,00-18.37 A

ATOM 3362 O DLE A473 -9.259- -6.344 -44.8151.0018.23 A

-ATOM ^""3763 N CYS-A 474 -10.049 -4.245 -44.775- 1.00J.7.91 A

ATOM 3764- CA CYS A 474 -9.052 -3.817-43.8301.-0017.96 A

ATOM 3765 CB CYS A 474 -7.9-82 -3.010-44.5491.0018.69 A ATOM 3766 SG CYS A 474 -8.596 -1.500 -45724« 1.0022.40 A

ATOM 3767 C CYS A 474 -9.732 -2.987-42.741 1.0017.38 A

ATOM 37680 CYS A 474 -10.836 -2.473-42.941 1.0015.98 A

ATOM 3769 N PRO A 475 -9.091 -2.880-41.560 1.0017.21 A

ATOM 3770 CD PRO A 475 -7.790 -3.513-41.265 1.0016.36 A _m

ATOM 3771 CA PRO A 475 -9.567 -2.135-40.391 1.0016.16 A

ATOM 3772 CB PRO A 475 -8.580 -2.553-39.3071.0016.23 A

ATOM 3773 CG PRO A 475 -7.321 -2.741-40.0781.0015.68 A

ATOM 3774 C PRO A 475 -9.548 -0.637-40.6481.0015.46 A

5. ATOM 37750 PRO A 475 -8.561 -0.106-41.1401.0015.04 A

ATOM 3776 N PRO A 476 -10.642 0.060-40.3241.0015.80 A

ATOM 3777 CD PRO A 476 -11.945 -0.501-39.9401.0016.17 A

ATOM 3778 CA PRO A 476 -10.741 1.510-40.5291.0016.16 A

ATOM 3779 CB PRO A 476 -T2.229 1.789-40.3121.0015.24 A 0 ATOM 3780 CG PROA476 -12.652 0.704-39.3991.0017.52 A

ATOM 3781 C PRO A 476 -9.831 2.334-39.663 1.0016.09 A

ATOM 3782 O PRO A 476 -9.530 3.520^0.025 LOO 17.93 A

ATOM 3783 N VAL A 477 -9.409 1.853-38.5201.0015.57 A

ATOM 3784 CA VAL A 477 -8.506 2.546-37.6071.0015.66 A 5 ATOM 3785 CB VAL A 477 -9.182 2.885-36.273 1.0012.96 A

ATOM 3786 CGl VAL A 477 -10.222 3.957-36.473 1.0011.95 A

ATOM 3787 CG2VALA477 -9.814 1.645-35.6951.0013.14 A

ATOM 3788 C VAL A 477 -7.376 1.561-37.3461.0018.07 A

ATOM 37890 VAL A 477 -7.545 0.361-37.5791.0018.65 A Q ATOM 3790 N THR A 478 -6.233 2.044-36.8671.0020.51 A

ATOM 3791 CA THR A 478 -5.091 1.165-36.615 LOO 22.21 A

ATOM 3792 CB THRA-478 -3^49 1.970 -36.2481.0022J3 A

ATOM 3793 OGl THRA-478 -3.673 3.027-37.2021.0CL23.83 A ATOM^" 3794- CG2 THR A 478 -2.617 1.073-36.269170022.49 A 5 ATOM- 3795-C THR A 4-78- -5.369 0.167-35.5001.0023^9 A

-ATOM 3796-0 THR A 478 -6.208- -0r432 -34.641 1.0025.09 A

ATOM 3797 N ARGA479^" -4.682^" -0:980 -35.5261.0023-91 A

ATOM 3798 CA ARG A 479^" -4.856 -2.026 -34.5061.0025.43 A

ATOM 3799 CB ARG A 479 -5.751 -3.166-35.021 1.0026.26 A 0 ATOM 3800 CG ARGA 479 -6.837 -2.784-36.0361.0025.49 A

ATOM 3801 CD ARG A 479 -7.930 -1.981-35.383 1.0025.49 A

ATOM 3802 NE ARG A 479 -8.647 -2.732-34.351 1.0024.68 A

ATOM 3803 CZ ARGA479 -9.124 -2.188-33.2341.0023.89 A

ATOM 3804 NHl ARG A 479 -8.953 -0.891-32.9861.0023.48 A ATOM 3805 NEC ARG A 479 -9.804 -2.929-32.3861.0023.53 A

ATOM 3806 C ARG A 479 -3.499 -2.626-34.111 1.0026.31 A

ATOM 3807 O ARG A 479 -2.512 -2.491-34.8381.0025.83 A

ATOM 3808 N ASN A 480 -3.477 -3.145-32.891 1.0027.66 A

ATOM 3809 CA ASN-A 480 -2.369 -3:838 -32.2821.0029.08 A

ATOM 3810 CB ASN A 480 -1.521 -2.922-31.4671.0030.24 A

ATOM 3811 CG ASN A 480 -2.241 -1.804-30.9201.0032.70 A

ATOM 3812 ODl ASN A 480 -3.160 -1.968-30.2391.0034.75 A

ATOM 3813 ND2ASNA480 -1.783 -0.631-31.175 LOO 34.84 A

ATOM 3814 C ASNA 480 -2.597 -5.099-31.512.1.0030.15 A

ATOM 3815 O ASN A 480 -3.677 -5.407 -3 L267 LOG 30.54 A

ATOM 3816 N GLUA 481 -1.593 -5.786-31.105 1.0030.84 A

ATOM 3817 CA GLUA 481 -1.869 -6.885-30.273 1.0031.75 A

ATOM 3818 CB GLU A 481 -0.639 -7.692-30.101 1.0030.91 A

ATOM 3819 CG GLU A 481 -0.277 -8.612-31.2101.00-32.71 A

ATOM 3820 CD GLU A 481 -1.396 -9.356-31.7561.0034.29 A

ATOM 3821 OEl GLU A 481 -1.246 -9.789-32.845 1.0034.23 A

ATOM 3822 OE2GLUA481 -2.401 -9.534-31.151 1.003.4.75 A

ATOM 3823 C GLU A 481 -2.315 -6.420-28.935 1.0032.11 A

ATOM 3824 O GLUA 481 -1:839 -6.896-27.9961.0034.79 A

ATOM 3825 N THR A 482 -3.218 -5.498-28.818 1.0031.25 A

ATOM 3826 CA THR:A-482 -3.813- -5.277 -27.560- 1.0030.63 A

ATOM 3827 CB- THR A 482 -3-519 -3.972-27:0241.00-3-1.03 A

ATΘM 3828 OGl THR A 482 -4.696 -3.J47 -26.610- 1.0032.48 A

ATOM 3829 CG2THRA_4:82 -3.155 -3.1-67-27.958 LOOθkOO A

ATOM 3830- C THRA-4S2T -5.217 -5Λ24 -27.781 1.0029.91 A

ATOM 3831 O- THR A 482 -6.012 -5.193 -26.968 bOTH-LOό A

ATOM 3832 N HIS A 483 -5.519 -5.904-28.9341JOO^"28.71 A

ATOM 3833 CA HIS A 483 -6.789 -5.728-29.433 1.0026.10 A

ATOM 3834 CB HIS A 483 -6.620 -5.049-30.6951.0026.58 A

ATOM 3835 CG HIS A 483 -6.584 -3.578-30.6181.0028.00 A

ATOM 3836 CD2 HIS A 483 -7.405 -2.701-30.033 1.0027.05 A

ATOM 3837 NDl HIS A 483 -5.507 -2.866-31.0101.0030.09 A

ATOM 3838 CEl HIS A 483 -5.702 -1.600-30.771 1.0028.75 A _m

ATOM 3839 NE2HISA483 -6.855 -1.470-30.185 1.0027.98 A

ATOM 3840 C HIS A 483 -7.138 -7.116-29.6861.0024.65 A

ATOM 3841 O HIS A 483 -6.304 -7.918-29.713 1.0023.77 A

ATOM 3842 N PHE A 484 -8.380 -7.432-29.8591.0023.61 A ATOM 3843 GA PHE A 484 -8.741 -8.822-30.0401.0023.94 A

ATOM 3844 CB PHE A 484 -8.922 -9.491-28.683 1.0023.00 A

ATOM 3845 CG PHE A 484 -9.232-10.947-28.773 1.0024.55 A

ATOM 3846 CDl PHE A 484 -8.502-11.772-29.629 1.0025.25 A

ATOM 3847 CD2PHEA484 -10.252-11.500-28.0091.0025.69 A ATOM 3848 CEl PHE A 484 -8.786-13.126-29.7301.0025.29 A

ATOM 3849 CE2 PHE A 484 -10.547-12,853-28.0981.0025.95 A

ATOM 3850 CZ PHE A 484 -9.813 -L3.668 -28.9641.0026.91 A

ATOM 3851 C PHE A 484 -10.040 -8.816-30.823 1.0024.58 A

ATOM 3852 Q PHEA484 -11.103 -9.196-30.3271.0025.89 A ATOM 3853 N ASP A 485 -9.928 -8.372-32.0661.00.23.54 A

ATOM 3854 CA ASP A 485 -11.Q64 -8.247-32.9441.0022.07 A

ATOM 3855 CB ASPA485 -10.601 -7.500-34.1991.0022.77 A

ATOM 3856 CG ASPA 485 -9.993 -6.132 -33.8591.Θ022.94 A

ATOM 3857 ODl ASP A 485 -10.671 -5.329-33.188 1.0022.56 A ATOM 3858 OD2ASPA485 -8.840 -5.852-34.2501.0023.07 A

ATOM 3859 C ASP A 485 -11.784 -9.558 -33.2541.0021.18- A

ATOM 3.860- O ASP A 485 -12.961 -9-5.53-33.d05 1.0020.14 A

ATOM 3861 N ALA A 486 -11.097-10.68-3-33.101 L00.20τ66 A-

ATOM 3862 CA ALA A-486 -11.738-11.961 -33.356.1.00-2Ϊ.29 A ATOM 3863 CB ALAA 4S6 -10 J19 -13.073 -33.348 1.00=20.40 A

ATOM 3864 C ALA A 4M- -12J748 -1-2.170 -32.244 COO 22.27 A

ATOM 3865 O ALAA-486 -13.785-12:807-32.4261.0023.34 A

ATOM 3866 N- GLY A 487 -12.437-11.608.-31.0841,0022.55 A

ATOM 3867 CA GLY A 487 -13.311-11.744-29.936 1.0023.10 A ATOM 3868 C GLY A 487 -14.593-10.936-29.985 1.0023.85 A

ATOM 3869 O GLY A 487 -15.486-11.154-29.163 1.0025.35 A

ATOM 3870 N ALA A 488 -14.702-10.006-30.929 1.0023.27 A

ATOM 3871 CAALAA488 -15.903 -9.185-31.035 1.0023.25 A

ATOM 3872 CB ALAA488 -15.572 -7.849-31.661 1.0022.67 A _onn

200

ATOM 3873 C ALA A 488 -16.974 -9.893-31.8541.0024.16 A

ATOM 38740 ALA A 488 -18.035 -9.328-32.124 1.0025.32 A

ATOM 3875 N LYS A 489 -16.693-11.131-32.246 1.0023.93 A

ATOM 3876 CA LYS A 489 -17.651-11.929-33.004 1.0024.18 A ATOM 3877 CB LYS A 489 -16.961-12.622-34.180 1.0023.27 A

ATOM 3878 CG LYS A 489 -17.865-13.560-34.964 1.0020.31 A

ATOM 3879 CD LYS A 489 -19.061-12.819-35.5421.0021.67 A

ATOM 3880 CE LYS A 489 -20.101-13.788-36.081 1.0021.97 A

ATOM 3881 NZ LYS A 489 -21.392-13.109-36.3791.0025.09 A ATOM 3-882 C LYS A 489 -18.337 -12.962 -32.115 1.0024.77 A

ATOM^" 3883 O LYS A 489 -17.68-3 -13,835 -31.543 1:0025.27 A

ATOM^' 3-884 N PHE A 490 -19.638-12.892-3-2.001 1.0023.86 A

ATOM 3885 CA PHE A 490 -20.316-13.692-31.0561.0024.54 A

ATOM 3886 CB PHE A 490 -21.715 -13.813 -31.360 l,α024.42 A ATOM 3887 CG PHE A 490 -22.435 -14.790 -50.527 LOQ 25.79 A

ATOM 3888 CDl PHE A 490 -23.287-14.428-29.5871.0025.24 A

ATOM 3889 CD2 PHE A 490 -22.348-16.066-30.771 1.0025.91 A

ATOM 3890 CEl PHE A 490 -23.926 -15.318 -28.9391.0024.39 A

ATOM 3891 CE2PHEA490 -23.040-16.933-30.128 1.0025.39 A ATOM 3892 CZ PHRA 490 -23.781-16.561-29.210 1.0024,73 A

ATOM 3893 C PHEA490 -19.786-15.001-30.818 1.0025.27 A

ATOM- 3894 θ -PHE A 490 -19.787-15.476-29.758 1.0025.38 A.

ATOM-3895 N HIS A 491 -19.288-15.640-31.816 l.OQ 25.15 A

ATOM 3896 CArJHS A 491 -I9τθ6-1 -1X081 -3L807 -LflQ24746 A ATOM 3897 CB HIS A 491 -19.072-17.632=33.2341.00:23.77- A

ATΘM- 3898-CG HIS A 491 =20.429 -17.647 -33.866 LQO 24J.8- A

ATOM 3899 CD2HISA491 -21.081 -16.716-34.603 1.00_25.02 A

ATOM r3900 NDl HIS A 491 -2L284 -1-8.725 -33.7691.0025.73 A

ATOM 3901 CEl HIS A 491 -22.401-18.457-34.419 1.0026.06 A ATOM 3902 NE2 HIS A 491 -22J04 -17.245 -34.9341.0026.09 A

ATOM 3903 C HIS A 491 -17.743-17.426-31.121 1.0024.46 A

ATOM 3904 O HIS A 491 -17.552-18.549-30.655 1.0023.14 A

ATOM 3905 N VAL A 492 -16.846-16.434-31.078 1.0024.78 A

ATOM 3906 CA VAL A 492 -15.512-16.655-30.5081.0026.46 A . _m

ATOM 3907 CB VAL A 492 -14.467-15.594-30.9591.0027.00 A

ATOM 3908 CGl VAL A 492 -13.158-15.801-30.1821.0026.88 A

ATOM 3909 CG2VALA492 -14.188-15.729-32.4541.0025.03 A

ATOM 3910 C VAL A 492 -15.578-16.697-28.985 IJOO 26.30 A ATOM- 3911 O VAL A 492 -15.014-17.599-28.3701.0027.38 A

ATOM- 3912 N ^"PRO A 493 -16.260-15.724-28.3891.0025.57 A

ATOM 3913 CD PRO A 493 -16.768-14.503-29.0351.0025.53 A

ATOM 3914 CA PRO A 493 -16.461-15.705-26.9361.0024.27 A

ATOM 3-915 CB PRO A 493 -17.189-14.378-26.700 1.0023.63 A ATOM 3916 CG PRO A 493 -17.756-14.007-28.027 LOO 25.03 A

ATΘM- 3917 C PROA493 -17324 -16τ871 -26.4661.0023.96- A

ATOM 3918 O PROA 493 -16.996-17.517-25.471- 1.0026.34 A

ATOM 3919 N ASN A 494 -18.415-17.132-27.179 1.0022.69 A

ATOM 3920. CA ASN A 494 -19.312-18.229-26.833 1.0022.06 A. ATOM 3921 CB ASN A 494 -20.752-17.886-27.2191.0023.76 A

ATOM 3922 CG ASN A 494- -2L264 -16.645 -26.513 1.0027.02 A

ATOM 3923 ODl ASN A 494 -22.279-16.687-25.81-81,0030.57 A

ATOM 3924 ND2 ASN A 494 -20,563 -15.533 -26-6891.0028.71 A

ATOM 3925 C ASN A 494 -18,893-19.544-27.4841.0021.16 A ATOM 39260 ASN A 494 -19.722-20.425-27.7131.0020.92 A

ATOM 3527 N VAL A 495 -17.604 -1-9-.668 -27..7J91.0020.40 A

ATOM 3928 -CA VAL A 495 -17.025 -20.95L -28.-1621.00-20.97 A

ATOM 3929 CJB VAL A 495 -16.618-21.778-26.928. l.QD-rST.61 A

ATOM 393Θ CG1VALA-495 -15.980 -23-J.92 -22.3541,001-8.76 A ATOM ^"3934 CG2 VAL A 495- -15.674 -20.9S2 -26.040 1,0019.94 A

ATOML 3932 C VAL A 495 -17.999 -21.764 -29.010-T.00-21.79 A

ATOM 3933 O_ VAL A 495^{^} -18.423 -22τ849^-2«:6151.0020.46- A

ATOM 3934 N THR A 496 -18.3.46 -21.231 -30.1771.0022_69 A

ATOM 3935 CA THR A 496 -18.966-22.028-31.2291.0023.52 A ATOM 3936 CB THRA 496 -20.254-21.349-31.731 1.0024.42 A

ATOM 3937 OGl THR A 496 -21.364-21.773-30.9301.0023.96 A

ATOM 3938 CG2THRA496 -20.614-21.852-33.121 1.0025.36 A

ATOM 3939 C THR A 496 -18.003-22.251-32.391 1.0023.29 A

ATOM 3940 O THR A 496 -17.408-21.305-32.9061.0024.04 A _om

ATOM 3941 N PRO A 497 -17.856-23.508-32.799 1.0023.40 A

ATOM 3942 CD PRO A 497 -18.380-24.706-32.123 1.0022.G6 A

ATOM 3943 CA PRO A 497 -17.173-23.835-34.055 1.0023.92 A

ATOM 3944 CB PRO A 497 -17.335 -25.355 -34.1541.0tT24.09 A ATOM 3945 CG PRO A 497 -17.584^"-25.8(R -32.7571:0023.68 A

ATOM 3946 C PRO A 497 -17,842 -.23.161 -35.2491.0023:61 A

ATOM 39470 PRO A 497 -19.067-23.053-35.285 1.0022.86 A

ATOM 3948 N TYR A 498 -17.042-22.713-36.211 1.0023.19 A

ATOM 3949 CA TYR A 498 -17.561-21.932-373261.0023.11 A ATOM 3950 CB TYR A 498 -16.848 -20.572 -37.382^" 1.0022.02 A

ATOM 3951 CG TYR A 498 -17.719 -19.401 -37.825 L00^~20.52 A

ATOM 3952 CDl TYR A 498 -18.567-18.754-36.928 1.0019:83 A

ATOM 3953 CEl TYR A 498 -19.373-17.672-37.3361.0019.95 A

ATOM 3954 CD2 TYR A 498 -47.693 -18.940 -39.148 1.0020.70 A ATOM 3955 CE2TYRA498 -18.495 -17.862 -39.3671.-0020.22 A

ATOM 3956 CZ TYR A 498 -19.331 -17.233 -33.6591.0020.07 A

ATOM 3957 OH TYRA 498 -20.125-L6.184-39.0751.0020.il A

ATOM 3958 C TYR A 498 -17.502-22.603-38.701 1.0024.48 A

ATOM 3959 O TYR A 498 -18.372-22.348-39.5461.0024.64 A ATOM 3960 N ILE A 499 -16.515-23.472-38.9341.0024.67 A

ATOM 396-1 CA ILE A 499 -16.388 -24 J 14 -40T2561.0025.17 A-

ATOM 3962 CB ILE A 499 -15.229 -25.144 -40.318^" 1.OO24-.77 A

ATOM 3963 CG2 ILE-A-499 -l-5÷6-l-θ -26.429 -39.585 1.00.24.34 A

ATΘM 3964^* CGl ILE A 499 -14.916^"-25.5Il -41.777- 1.0024.35 A ATOM 3965 CDl ILE A 499 -I^~4ϊ635 -24.337-42:673 fcOO 22.78 A

ATOM 3966 C ILE A 499 -17.639-24.819 -40.7141.ΘG25.28- A

ATOM 396-7- O ILE A 499 -17.69Ψ-25316 -41.-S25 1.O026.23 A

ATOM 3968- N ARGA 500 -18.639-24.870-39.849 1.0026.-48 A

ATOM 3969 CA ARG-A 500 -19.900-25.524-40.162 1-.Q027.79 A ATOM 3970 CB ARG A 500 -20.647-25.834-38.8721.0029.54 A

ATOM 3971 CG ARGA 500 -19.860-25.377-37.6491.0033.75 A

ATOM 3972 CD ARG A 500 -20.715-25.292-36.415 1.0034.51 A

ATOM 3973 NE ARG A 500 -20.356-26.323-35.4481.0035.82 A

ATOM 3974 CZ ARG A 500 -21.046-26.557-34.341 1.0036.29 A _n

ATOM 3975 NHl ARG A 500 -22.124-25.819-34.071 1.0033.84 A

ATOM 3976 NH2 ARG A 500 -20.659-27.534-33.525 1.0039.33 A

ATOM 3977 C ARG A 500 -20.761-24.607-41.0301.0027.43 A

ATOM 3978 O ARGA.500 -21.547-25.087-41.841 1.0027.93 A ATOM 3979 N TYRA 501 -20.623 -23.292 -40.854 1.00-27.12 A

ATOM 3980 CA TYRA 501 -21.412 -22.344^~-41.636 1.0027.51 A

ATOM 3981 CB TYRA 501 -21.349-20.950-41.018 1.0029.59 A

ATOM 3982 CG TYRA 501 -22.002-20.893-39.663 1.0031,64 A

ATOM 3983 CDl TYR A 501 -21.249-20.667-38.513 1.0033;S0 A ATOM 3984 CEl TYR A 501 -21.844-20.671-37.251 1.0033.88 A

ATOM 3985 CD2TYRA-501 -23.372-21.116-39.521 LOO 30.84 A

ATOM 3586 CE2 TYRA 501 -23.976 -21.123 -3«275 LOO 31.43 A

ATOM 3987 CZ TYRA 501 -23.206-20.903-37.138 1.0033.23 A

ATOM 3988 OH TYRA 501 -23.788-20.939-35.891 1.0033.3«- A ATOM 3989 C TYR A 501 -20.982-22.289-43.090 1.0026.Sl A

ATOM 3990 O- TYRA 501 -21.765-21.909-43,9591.0026.18 A

ATOM 3991 N PHE A 502 -19.731 -22:664 -43.342 1.0026.48 A

ATOM 3992 CA PHE A 502 -19.177-22.704-44.692 1.0023.75 A

ATOM 3993 CB PHE A 502 -17.662-22.898-44.636 1.0023.92 A ATOM 3994 CG PHEA 502 -16.991 -22:826 -45.972 1.0024.93 A

ATOM 3995 CDl PHE A 502 -16.839.-21.602 -46.6261.90L25.73 A

ATOM 3996 CDZPHE A 502 -££506-23.973 -46.5791.0024.29 A

ATOM 3597 CEl PHE A.5G2 -1-6.192 -2L53Q -4-7,865 1.0024τ82- A_

ATOM 3998 -CE2PHE_A 502 ~l-5.871-23.904 -47.815 kO024.O5_ A AlOM 3999 CZ^PHEA 502 -15.714 -22:6:82 -48.455.1.00^"25fi4 ^~A

ATOM 4000 C PHEL&502 -19.81-9-23.915-4-5.3461-.Θ022JB4 A

ATOM 4001 G PHFA 502 -20.491 -23:801" -46.3761.0022.64- A

ATOM 4ΘO2^'N VAL A 503 -19.612-25.070-44.7.18 1.0021.04 A

ATOM 4003 CA VAL A 503 -20.161 -26.329 -45J95 1.0020.36 A ATOM 4004 CB VAL A 503 -20.016-27:418-44.1141.0019.43 A

ATOM 4005 CGl VAL A 503 -20.684-28.700-44.561 1.0018.92 A

ATOM 4006 CG2 VAL A 503 -18.547-27.660 -43.8191.0017J0 A

ATOM 4007 C VAL A 503 -21.632-26.107-45.5041.0020.09 A

ATOM 4008 O VAL A 503 -22.140-26.490-46.5591.0020.21 A _9n,

204

ATOM 4009 N SERA 504 -22.290-25.448-44.5661.0019.89 A

ATOM 4010 CA SERA 504 -23.696-25.126-44.6591.0021.30 A

ATOM 4011 CB SERA 504 -24.096-24.338-43.416 1.0020.48 A

ATOM 4012 OG SERA 504 -25.436-23.918-43.485 1.0015.72 A ATOM 4013 C SER A 504 -24.034-24.324-45.9191.0023.58 A

ATOM 4014 O SERA 504 -24.906-24.702-46.703 1.0024.73 A

ATOM 4015 N PHE A 505 -23.336-23.215-46.1221.0024.99 A

ATOM 4016 CA PHE A 505 -23.610-22.388-47.2781.0025.81 A

ATOM 4017 CB PHE A 505 -22.820 -21.083 -47.172^" 1.0026.60 A ATOM 4018 CG PHE A 505 -23.547-20.007-46.4001.0028.93 A

ATOM 4019 CDl PHE A 505 -24.062.-20.273-45.1361.0030.23 A

ATOM 4020 CD2PHEA505 -23.739-18:735-46.9461.0028.87 A

ATOM 4021 CEl PHE A 505 -24.756-19.300-44.4291.0031.44 A

ATOM 4022 CE2 PHE A 505 -24.434 -17.746 -46.2461.0029.34 A ATOM 4023 CZ PHE A 505 -24.944-18.029-44.985 1.0031.07 A

ATOM 4024 C PHE A 505 -23.364-23.095-48.6061.0025.85 A

ATOM 4025 O PHE A 505 -23.994-22.784-49.620 1.0025.28 A

ATOM 4026 N VAL A 506 -22.464 -24.065 -48.6121.0026.29 A

ATOM 4027 CA VAL A 506 -22.219-24.783-49.848 1.0025.96 A ATOM 4028 CB VAL A 506 -20.777-25.356-49523 1.0025.44 A

ATOM 4029 CGl VAL A 506 -20.719-26.528-50.908 1.0022.82 A

ATOM 4030 CG2 VALA 5Q6 -19.799 -24.2W -50.358 1.0023.64 A

ATOM 4031 C VAL A 506 -23.228-25.904-50.036 1.0026.77 A

ATOM 4032 O VALA 506^" -23.761 -26.052 -5U361.0029.18 A ATOM 4033 N LEUA-507 -23.526-26-683-48.993 1.0025.74- A

ATOM 4034- CA LEUA 507^~ -24.483 -27.770 -49rl94- 1.0025.50 A

ATOM 4035 CB LEU A 507 -24.096 -29J029 -48.400- 1.0025.94 A

ATOM 4036 CG LEU A 507 -24.S09 -29.424 -47.1081.0025.15 A

ATOM 4037 CDl LEU A 507 -24.733-30.918-46.903 1.0024.78 A ATOM 4038 CD2LEUA507 -24.168-28.694-45.961 1.0025.90 A

ATOM 4039 C LEU A 507 -25.941-27.438-48.9471.0025.50 A

ATOM 4040 O LEU A 507 -26.769-28.336-48.8621.0026.83 A

ATOM 4041 N GLN A 508 -26.273-26.158-48.8421.0026.02 A

ATOM 4042 CA GLN A 508 -27.670-25.793-48.6391.0026.02 A ATOM 4043 CB GLN A 508 -27.801-24.419-47.9641.0025.89 A

ATOM 4044 CG GLN A 508 -27.631-23.180-48.8381.0027.95 A

ATOM 4045 CD GLN A 508 -27.623-21.886-48.0041.0030.56 A

ATOM 4046 OEl GLN A 508 -28.133-20.839-48.4341.0030.96 A ATOM 4047 NE2 GLN A 508 -27.030-21.958-46.8071.0030.26 A

ATOM 4048 C GLN A 508 -28.310-25.796-50.0101.0026.18 A

ATOM 4049 O GLN A 508 -29.500-26.049-50.149 1.0026.89 A

ATOM 4050 N PHE A 509 -27.500-25.533-51.0301.0026.98 A

ATOM 4051 CA PHE A 509 -27.988-25.531 -52.403 LOO 27.26 A ATOM 4052 CB PHE A 509 -27.099 -24.657-53.2941.0027. L5 A

ATOM 4053- CG PHE A 509 -27.132-23.193-52.9431.0027.97 A

ATOM 4054 CDl PHE A 509 -26.263-22.669-51.9921.0028.60 A

ATOM 4055 CD2PHEA509 -28.028-22.336-53.5621.0026.97 A

ATOM 4056 CEl PHE A 509 -26.285 -21.316 -51.6701.0027.01 A ATOM 4057 CE2 PHE A 509 -28,054-20.984-53.241 1.0027.79 A-

ATOM 4058 CZ PHE A 509 -27.183-20.477-52.2961.0026.34 A

ATOM 4059 C PHE A 509 -28.057 -26.963 -52.967 l-.OΘ 27.40 A

ATOM 4060 O PHE A 509 -28.881-27.247-53.8391.0027.00 A

ATOM 4061 N GLNA 510 -27 '.192 -27 '.860 -52.4821.0027 '.28 A ATOM 4062 CA GLN A 510 -27.233-29.245-52.9561.0026.52 A

ATΘM 4063 CB GLNA 510 -26.187-30.127-32.2701.O023.00 A

ATOM 4064 CG GLN AJ510 -24\748 -29.757-52.518 LOO 19.85 A

ATOM 4065 CD GLN A 51 θ -23.831-30.950-52.393 1.0019.65 A

ATOM 4Θ66J9M GkN A 510 -22.654 -3tt8ϊ7 -52.088 T.ΘΘ- 19.40- A ATOM 4067 ME2 GLN A 510 -243.65. -32.128 -52τ642 LOD 20.64 A

ATΘM 4668^"C GLN A 51-0 -28.6-16-29.751-52573 1.00.27.40 A

ATOM 4069 O GLNΑ-51O -29.264-30.483-53.331 LOO 28.47 A

ATOM 4070 N PHEA511 -29.048-29.336-51.383 1.0026.68- A

ATOM 4071 CA -PHE A 511 -30.351-29.695-50,8371.0026.98 A ATOM 4072 CB PHE A 511 -30.497-29.202-49.383 1.0029.08 A

ATOM 4073 CG PHE A 511 -29.799-30.047-48.343 1.0028.82 A

ATOM 4074 CDl PHE A 511 -28.818-30.968-48.6841.0029.51 A

ATOM 4075 CD2PHEA511 -30.097-29.857-46.998 1.0029.18 A

ATOM 4076 CEl PHE A 511 -28.140-31.686-47.693 1.0029.62 A _9fVς

206

ATOM 4077 CE2 PHE A 511 -29.427 -30.562 -46.008 1.0029.58 A

ATOM 4078 CZ PHE A 511 -28.444-31.481-46.3581.0029.77 A

ATOM 4079 C PHE A 511 -31.436-29.024-51.6721.0025.88 A

ATOM 4080 O PHE A 511 -32.415-29.655-52.0451.0025.35 A ATOM 4081 N HIS A 512 -31.256 -Z7.735 -51.943 1.0026.06 A

ATOM 4082 CA HIS A 512 -32.226-26:968-52.7141.0026.84 A

ATOM 4083 CB HIS A 512 -31.762-25.518-52.8621.0026.99 A

ATOM 4084 CG HIS A 512 -32.778-24.616-53.493 1.0027.39 A

ATOM 4085 CD2HISA512 -32.653-23.652-54.4341.0028.09 A ATOM 4086 NDIlBS A 512 -34.107-24.620-53.1261.0029.00 A

ATOM 4087 CEl HIS A 512 -34.757 -23.698 -53.8161.0030.09 A

ATOM 4088 NE2 HIS A 512 -33.897-23.096-54.6161.0024.35 A

ATOM 4089 C HIS A 512 -32.451-27.571-54.0871.0027.69 A

ATOM 4090 O HIS A 512 -33.562-27.553-54.603 1.0028.48 A ATOM 4091 N GLUA513 -31.394 -28 Ji 04 -54.683 1.0027.80 A

ATOM 4092 CA GLU A 513 -3T.514 -28.712 -55.9961.0027.64 A

ATOM 4093 CB GLU A 513 -30.125-28.999-56.5761.0027.10 A

ATOM 4094 CG GLU A 513 -30.122-29.406-58.0391.0027.91 A

ATOM 4095 CD GLU A 513 -28.728-29.715-58.5641.0028.74 A ATOM 4096 OEl GLU A 513 -2&.028 -30.533 -57.9401.0029.15 A

ATOM 4097 OE2 GLU A 513 -28.327 -29.150 -59.6021.0029.07 A

ATOM 4098 G GLUA 513 -32.277-30,008 -55.786- 1.0028J^- A

ATOM 4099 O GLUA 513 -33.372-30,190-56.307 H)O 27.93 A

ATOM- 4100 N ALAAJJ4- -31.693 -3&891 -54:9871.0028.71 A ATOM 4101 CA ALA A 514 -32.287-32.187-54.691 1.0029,8-1 A

ATΘM 4TΘ2- CB- ALA A 514 -31.496-32.880 -.53.573 1.0029.28 A

ATQM 4103 C ALA-A 514 -33.771 -32. U9 -54.3201.0031.13 A

ATOM 4104 O ALAA 5-14 -34.557-32.976-54.736 LOO 31.89 A

ATOM 4105 N LEUA 515 -34.162-31.117-53.5391.0031.68 A ATOM 4106 CA JLEU A 515 -35.560-31.006-53.1461.0033.55 A

ATOM 4107 CB LEUA 515 -35.712-30.095-51.9191.0033.56 A

ATOM 4108 CG LEU A 515 -35.091-30.687-50.6361.0033.78 A

ATOM 4109 CDl LEU A 515 -35.297-29.733-49.4621.0032.18 A

ATOM 4110 CD2LEUA515 -35.710-32.059-50.3341.0032.77 A _im

207

ATOM 4111 C LEUA 515 -36.422-30.516-54.295 1.0034.69 A

ATOM 4112 O LEUA 515 -37.514-31.034-54.525 1.0035.01 A

ATOM 4113 N CYS A 516 -35.929-29.532-55.033 1.0035.86 A

ATOM 4114 CA CYS A 516 -36.682 -29.012. -56.160 1.0036.89 A ATOM 4115 C CYS A 516 -36.934-30.094-57.198 1.0038.08 A

ATOM 4116 O CYS A 516 -37.950-30.074-57.8901.0037.74 A

ATOM 4117 CB CYS A 516 -35.941-27.844-56.791 1.0036.33 A

ATOM 4118 SG CYS A 516 -35.898-26.398-55.7001.0037.29 A

ATOM 4119 N LYSA 517 -36.009-31.042-57.3071.0039.90 A ATOM 41^"2O CA LYS A 517 -36.181-32.121-58.2671.0041.39 A

ATOM 4121 CB LYS A 517 -34.907-32.960-58.3971.0040.02 A

ATOM 4122 CG LYS A 517 -34.962-33.956-59.545 1.0039.66 A

ATOM 4123 CD LYS A 517 -33.669-34.730-59.6771.0041.10 A

ATOM 4124 CE LYS A 517 -33.794-35.860-60.699 1.0042.94 A ATOM 4125 -NZ LYS A 517 -34.016-35.375-62.0961.0044.20 A.

ATOM 4126- C LYS A 517 -37.348-33.001-57.8321.0043.56 A

ATOM 4127 O LYS A 517 -38.252-33.264-58.6291.0045.90 A

ATOM 4128 N GLUA 518 -37.439-33.408-56.591 1.0044.27 A

ATOM 4129 CA GLU A 518 -38.564-34.244-56.2191.0044.14 A ATOM 4130 CB GLU A 518 -38.345-34.915-54.937 1.0044.65 A

ATOM 413:1 CG GLU A 518 -37J95 -36.179 -55.1181.0046.2T A

ATOM -4132- CD GLU A 518 -38.448 -3-7.300. -54.S55 1.0047.80 A.

ATOM- 4133 OELGLU A 518 -38.079-38.241-54.1971.0048.96 A ATOM 4134 OE2 GLUA 5±8: -39.532-37.229-55.3211. OQ 49.99 -A ATOM 4135 C GLUAJ18 -39.812-33.534-56.105 1.00^"43:66 A

ATOM 4136-θ GLUA-518- -40.832-34-091-56.204 IJO 43.02 A

ATOM 4137 N ALAA 519 -39.748 -32.277 -55.S52 ITOO 43.95 A

ATOM 413.8 CA ALAA 519 -40.985-31.513-55.873-1.0044.83 A

ATOM 4139 CB ALA A 519 -40.709-30.050-55.5401.0044.04 A ATOM 4140 C ALAA519 -41.579-31.630-57.2701.0045.48 A

ATOM 4141 O ALAA 519 -42.798-31.608-57.4481.0046.33 A

ATOM 4142 N GLYA 520 -40.704-31.768-58.2601.0045.57 A

ATOM 4143 CA GLY A 520 -41.150-31.871-59.6321.0045.67 A

ATOM 4144 C GLY A 520 -41.102-30.508-60.2881.0046.39 A ATOM 4145 O GLY A 520 -41.801-30.238-61.265 1.0046.26 A

ATOM 4146 N TYRA 521 -40.263-29.633-59.7441.0047.25 A

ATOM 4147 CA TYR A 521 -40.041-28.319-60.3361.0047.13 A

ATOM 4148 CB TYR A 521 -39.465-27351-59.300 1.0046,85 A ATOM 4149 CG TYΗTA-521 -39.260 -25.948 -59.823 1.0047.30 A

ATOM 4150 CDl TYRA 521 -40.257 -^"2498S -59.7041.Θ047.81 A

ATOM 4151 CEl TYR A 521 -40.074-23.704-60.181 1.0046.74 A

ATOM 4152 CD2 TYRA 521 -38.070-25.582-60.4391.0046.23 A

ATOM 4153 CE2 TYR-A 521 -377878 -24.301 -60.9191.0045.27 A ATOM 4154 CZ TYR A 521 -38.883-23.366-60.788 1.0046.11 A

ATOM 4155 ΘH TYRA 521 -38.698-22.0S9 -61.265 1.00-47.40 A

A-TOM 41-56 C TYRA 521 -39:115 -28.405 -.61-.544 1.00-47.94 A

ATOM 4157 O TYRA 521 -38.236-29.264-61.605 1.0047.33 A

ATOM 4158 N GLU A 522 -39.426-27.639-62.553 1.0049.45 A ATOM 4159 -CA GLU A 522 -38.46&-27.3S6 -63.5671.0050.87 A

ATOM 4160 CB GLU A 522 -38.577-28.379-64.6701.0051.32 A

ATOM 4161 CG GLU A522 -37.546-29.445-64.6181.0053.71 A

ATOM 4162 CD GLU A 522 -38.129-30.732-65.0341.0055-56 A

ATOM 4163 OEl GLUA 522 -39.214 -30. #79 -65.622 1.0056.26 A ATOM 4164 OE2 GLUA 522 -37.515-31.767-64.760 1.0056,12 A

ATOM 4165 C GLU A 522 -38.686-26.043-64.1141.005Q..8.Θ A

ATOM 4166 O GLU A322 -39.743 -23.48$ -63.9891.0052.29 A

ATΘM-4167 N GLY A 523 -37.664 -25.521 -64.73-2 1.0049.28 A

ATOM 4J6§--£A GEYA- 523 -37.346-24.156 -64.56G-kQβ-47.02 A ATOM 4169 C GEY A 523 -36:123-24:125-63.7401.0045.60 A

ATOM 4170- O fiLY A 523 -35.501 -25.131 -63.-594^' 1.0G4637 A

ATOM 4171 N PRO A 524 -35.806 -22.9^ -63.199 1.0Θ4Ϊ.67 A

ATOM 4172 CD PRO A- 524 -36.442-21.859-63.8871.0042.87 A

ATOM 4173 CA PRO A 524 -34.474-22.577-62.960 1.0042.11 A ATOM 4174 CB PRO A 524 -34.503-21.187-63.455 1.0041.55 A

ATOM 4175 CG PRO A 524 -35.290-21.243-64.4001.0041.14 A

ATOM 4176 C PRO A 524 -34.144-22.554-61.5461.0041.51 A

ATOM 4177 O PRO A 524 -34.832-22.077-60.7051.0041.91 A

ATOM 4178 N LEU A 525 -33.005-23.081-61.2491.0039.56 A _2Q9

ATOM 4179 CA LEUA 525 -32.867-23.540-59.873 1.0037.93 A

ATOM 4180 CB LEUA 525 -31.477-24.136-59.643 1.0035.41 A

ATOM 4181 CG LEUA 525 -31.190-24.660-58.2351.0033.34 A

ATOM 4182 CDl LEU A 525 -32.248-25.667-57.8091.0031.38 A ATOM 4183 CD2LEUA-525 -29.800-25.274-58:1621.0031.54 A

ATOM 4184 C LEU A 525 -33.121-~22.406--58.885 1.01)38.05 A

ATOM 4185 O LEU A 525 -33.595-22.633-57.7721.0038.87 A

ATOM 4186 N HIS A 526 -32.803-21.184-59.300 1.0036.81 A

ATOM 4187 CA HIS A 526 -32.948-20.026-58:4401.00-35.30^" A ATOM 4188 CB HIS A 526 -31.924-18.948-58.813 1.0034.19 A

ATOM 41-89 CG HIS A 526 -32.271-18.173-60.0421.0033.72 A

ATOM 4190 CD2 HIS A 526 -32:839 -1-6,951 -60.191 1.0033.62 A

ATOM 4191 NDl HIS A 526 -32.026-18.638-61.313 1.0033.80 A

ATOM 4192 CEl HIS A 526 -32.424-17.73-7-62.1941.0033.94 A ATOM 4193 NE2HISA526 -32.921 -16.704-61.5371.0032.71 A

ATOM 4194 C HIS A 526 -34.346 -19.428 -58.4301.0035.67 A

ATOM 4195 O HIS A 526 -34.572-18.374-57.8371.0036.50 A

ATOM 4196 N GLNA 527 -35.287-20.085-59.0901.0035.11 A

ATOM 4197 CA GLN A 527 -36.650-19.579-59.0991.0035.85 A ATOM 4198 CB GLN A 527 -37.081-19.175-60.512 1.0037.47 A

ATOM 4199 CG GLNA 527 -36.416--FTTSOO -61.012. LOO 3932 A

ATOM 4200 CD GLN A- 527 -36.9S8 -17.414~62.33T 1-0039.65 A-

ATOM 4201- OEl GLN A 527 -37.165 -18.196-63.262 JLOO 38.71 A

ATOM 4202 NE2 GLN A 527 -37.273-16; 116 -62÷418 1.0039.83 A- ATOM 4203 C GLN A 527 -37.565.-20.653 -58.550^" 1.0035τ52 A^~

ATΘM, 4204 O- GLN A 527 -38.779-2Θ.486.-5&4691.0034.58 A

ATOM 4205 N CYS A 528 -36.961 -21.762 -5S.160_1.0O 36.50 A-

ATOM 4206 CA CYS A 528 -37.717-22.864-57.6051.0037^1 A

ATOM 4207 C CYS A 528 -38.269-22.515-56.2351.0038.13 A ATOM 4208 O CYS A 528 -37.653-21.759-55.4761.0038.75 A

ATOM 4209 CB CYS A 528 -36.838-24.107-57.4891.0037.95 A

ATOM 4210 SG CYS A 528 -37.497 -25.289 -56.2791.0038.36 A

ATOM 4211 N ASP A 529 -39.432-23.076-55.9271.0037.97 A

ATOM 4212 CA ASPA 529 -40.086-22.852-54.6521.0038.25 A ATOM 4213 CB ASP A 529 -41.087-21.708-54.7671.0037.84 A

ATOM 4214 CG ASP A 529 -41.956-21.572-53.5371.0038.24 A

ATOM 4215 ODl ASP A 529 -41.405-21.649-52.4191.0037.67 A

ATOM 4216 OD2 ASP A 529 -43.184 -21.378 -53.6871.0038.42 A ATOM 4217 C ASP A 529 -40.798-24.128-54.2701.0038.73 A

ATOM 4218 O ASP A 529 -41.890-24.396-54.7491.0037.90 A

ATOM 4219 N DLE A 530 -40.175-24.917-53.402 1.0040.75 A

ATOM 4220 CA ILE A 530 -40.762-26.188-52.988 1.0043.46 A

ATOM 4221 CB ELE A 5.30 -39.710 -27.097 -52.2501.0043.25 A ATOM 4222 CG2 ILE A 530 -38.561-27.410-53.2301.0042.14 A

ATOM 4223 CGl BLEA 530 -39.192 -26.420 -51.0101.0043.02 A

ATOM 4224 CDl BLE A 530 -38.241 -27.276 -50.215 LQ04G.90 A-

ATOM 4225 C BLE A 530 -41.993-26.062-52.0821.0045.79 A

ATOM 4226 O BLE A 530 -42.406-27.042-51.451 1.0045.86- A ATOM 4227 N TYR A 531 -42.581 -24.868-52.027 LOO 47.88 A-

ATOM 4228 CA TYR A 531 -43.764-24.630-51.202 1.0050.06 A

ATOM 4229 CB TYR A 531 -44.304-23.222-51.4591.0052,41 A

ATOM 4230 CG TYR A 531 -45.457-22.800-5.0.561 1.0055.58 A

ATOM 4231 CDl TYR A 531 -45.318-22.766-49.169 1.0055.79 A ATOM 4232 CEl TYR A 531 -46.365-22.329-48.343 1.0056.94 A

ATOM 4233 CD2TYRA531 -46.675 -22.389 -5Jk 108 1.0057.15 A

ATOM 4234 CE2 TYR A 531 -47.726-21.949-50.296 UOO 58.69 A

ATOM 4235 CZ TYRA 531- -47.566- -21.919 -48.915 -1.00-58,51 A

ATOM 4236 -OH Tm A 531 -33L606 -2M69 -4871241.0058.41 A. ATOM 4237 _C_ TYR-A 531- -44.868 -25.668 -5-1.460 LOO 50.33 A

ATOM 4238 O TYRA 531 -45._:ø-7-2'-26.115 -52,593 1.0050.83 A

ATOM 4239 N ARGA1532 -45.566-26.044 -503S7- LOO 49:47 A

ATOM 4240 CA ARG A 532 -46.652 -27.026 -50.4161.0047.50 A

ATOM 4241 CB ARG A 532 -47.924 -26.409 -51.02S 1.0047.42 A ATOM 4242 CG ARG A 532 -48.614-25.369-50.132-1.0049.55 A

ATOM 4243 CD ARG A 532 -50.088-25.138-50.5091.0051.61 A

ATOM 4244 NE ARG A 532 -50.816-24.354-49.506 1.0053.81 A

ATOM 4245 CZ ARG A 532 -51.041-24.753-48.2521.0055.83 A

ATOM 4246 NHl ARG A 532 -50.600-25.932-47.832 1.0055.39 A ₉ , ,

211

ATOM 4247 NH2 ARG A 532 -51.694-23.964-47.402 1.0057.46 A

ATOM 4248 C ARG A 532 -46.336-28.365-51.095 1.0045.89 A

ATOM 4249 O ARG A 532 -47.247-29.119-51.435 1.0046.40 A

ATOM 4250 N SER A 533 -45.054-28.675-51.278 1.0043.49 A ATOM 4-251 CA SERA 533 -44.673-29.942-51.905 1.0041.83 A

ATOM 4252 CB SER A 533 -43392-29.794-52.7221.0040.57 A

ATOM 4253 OG SERA 533 -42.873-31.077-53.0341.0038.66 A

ATOM 4254 C SER A 533 -44.458-31.041-50.8801.0041.32 A

ATOM 4255 O SER A 533 -43.346-31.223-50.3851:0041.93 A ATOM 4256 N THR A 534 -45.515-31.782-50.571 1.0040.96 A

ATOM 4257 CA THR A 534. -45.414 -32.X65 -49-599 1.0040.54 A

ATOM 4258 CB- THR A 534 -46.768-33.566-49.391 1.0040.76 A ATOM 4259 OGl THR A 534 -47.106-34.302-50.568 1.0039.34 A ATOM 4260 CG2 THRA 534 -47,863-32.546-49.119 1.0041.67 A ATOM 4261 C THRA534 -44.400-33.908-50.053 LOD 39.66 A

ATOM 4262 O THR A 534 -43.838-34.638-49.2371.003839 A

ATOM 4263 N ALA A 535 -44.167-33-.972 -5L361 1.0039.88 A ATOM 4264 CA ALA A 535 -43.214-34.931-51.9071.0040.44 A

ATOM 4265 CB ALA A 535 -43.433-35.103-53.403 1.0039.16 A ATOM 4266 C ALA A 535 -41.778-34.504-51.6241.0040.59 A

ATOM 4267 O ALA A 535 -4D.913 -35.327-51.3071.0039.93 A

ATOM 4268 N- ALAA 536 -41.512-33.199-51.7341.0040.33 A ATOM 4269 CA ALA A-536 -40.184-32.671 -51.443 1.0039.48 A

ATOM^" 4270 CB ALAA 536 -40.116 -31.208 -5-1,829 1.0038183 A ATOM 4271 C ALAJL 534- -39.-897-3ZS33 -49τ94.L ^0039.46 A

ATOM -4272 O ALA-A-536 -38^883 -33.417 -49.5471.0θ-39tθ-7- A

JLTOM -4273 N GLY A 537 -40.808 -32.315 -49,IiT 1.0038.56- A ATOM 4274 CA GLY A 537 -40.661 -32.392 -47.6761.0037.77 A

ATOM 4275 C GLY A 537 -40.377-33.772-47.1041.0038.59 A ATOM 4276 O GLYA 537 -39.642-33.898-46,1221.0038.61 A

ATOM 4277 N ALA A 538 -40.956-34.807-47.703 1.0038.64 A ATOM 4278 CA ALA A 538 -40.757-36.172-47.2301.0038.07 A

ATOM 4279 CB ALA A 538 -41.687-37.096-47.9591.0037.50 A

ATOM 4280 C ALA A 538 -39.316-36.621-47.4361.0038.33 A ₀₁₀

212

ATOM 4281 O ALA A 538 -38.796-37.451-46.691 1.0037.98 A

ATOM 4282 N LYS A 539 -38.625-36.017-48.361 1.0038.99 A

ATOM 4283 CA LYS A 539 -37.288 -36.383 -48.695 1.0038.67 A

ATOM 4284 CB LYS A 539 -37.003 -35.788 -50.035 1.0037.54 A ATOM 4285 CG LYS A 539 -35.942-36.423-50.8821.0035.92 A

ATOM 4286 CD LYS A 539 -35.301-35.464-51.7421.003376 A

ATOM 4287 CE LYS A 539 -34.236-36.111-52.423 1.0032.69 A

ATOM 4288 NZ LYS A 539 -34.501-37.487-52.4301.0031.05 A

ATOM 4289 C LYS A 539 -36.373 -35.756 -47.7471.0039.63 A ATOM 4290 O LYS A 539 -35.362-36.289-47.4491.0038.85 A

ATOM 4291 N LEU A 540 -36.716 -34.559 -47.3301.0040.03 A

ATOM 4292 CA LEU A 540 -35.9.61 -33.8-19 -46.325 1.0040.45 A

ATOM 4293 CB LEU A 540 -36.488-32.390-46.2161.0038.46 A

ATOM 4294 CG LEUA-540 -35.563-31.266-45.725 1.0037-54 A ATOM 4295 CDl LEUA 540 -36.417-30.246-45.003 1.0036.97 A

ATOM 4296 CD2 LEU A 540 -34.480-31.776-44.805 1.0036.47 A

ATOM 4297 C LEU A 540 -36.096-34.491-44.964 1.0041.98 A

ATOM 4298 O LEU A 540 -35.103-34.732-44.271 1.0042.60 A

ATOM 4299 N ARG A 541 -37.296-34.866-44.6041.0042.12 A ATOM 4300 CA ARG A 541 -37.442-35.405-43.3201:0043.15 A

ATOM 4301 CB ARG A 541 -38.847-35.536-42.962 1.0045.48 A

ATOM 4302 -CG ARG A 541 -39.05.6 -3tf.86i -42.458- 1.0049.39 A

ATOM 4303 CD ARG A 541 -40.446-37.160 -4 L9-0.L 1.0052.41 Λ

ATOM 43.04- NE ARG-A:541 -41.481-36.323-42.440 trOO 56.57 A ATOM 4305 CZ ARG A541 -42.285 -36.685-43-406 M)O 58r70 A_ ATOM 4306 NHl ARG-A 541 -42.171 -37.860" -4T963 1.0055.03 A ATOM 4307 NH2 ARG-A .541- -43.204-35.872-43.8441.0059.11 A

ATOM 4308 C ARGA 541 -36.828-3.6.709-43,081 1.0042.29 A

ATOM 4309 O ARGA 541 -36.591-37.060-41.998 1.0042.33 A ATOM 4310 N ALA A 542 -36.587-37.466-44.0941.0040.90 A

ATOM 4311 CA ALA A 542 -35.796-38.685-43.9801.0039.39 A

ATOM 4312 CB ALA A 542 -35.738-39.408-45.3181.0039.38 A

ATOM 4313 C ALA A 542 -34.389-38.383-43.4751.0038.42 A

ATOM 43140 ALA A 542 -33.823-39.164-42.6981.0037.57 A _m

ATOM 4315 N VAL A 543 -33.806-37.294-43.933 1.0037.79 A

ATOM 4316 CA VAL A 543 -32.458-36.928-43.5201.0036.54 A

ATOM 4317 CB VAL A 543 -31.866-35.790-44.433 1.0035.43 A

ATOM 4318 CGl VALA 543 -32.566 -35 J95 -45.7741.0034.12 A ATOM 4319 CG2 VAL A 543 -31.998-34.431-43.7771.0033.76 A

ATOM 4320 C VAL A 543 -32.539-36.461-42.0691.0036.60 A

ATOM 4321 O VAL A 543 -31.673-36.777-41.243 1.0036.23 A

ATOM 4322 N LEU A 544 -33.597-35.715-41.763 1.0035.55 A

ATOM 4323 CA LEU A 544 -33.788-35.212-40.4181.0034.72 A ATOM 4324 CB LEU A 544 -35.048-34.345-40.3521.0031.47 A

ATOM 4325 CG LEU A 544 -34.969 -33.064 -41.178 LOO 29.88 A

ATOM 4326 CDl LEU A 544 -36.157-32.173-40.903 1.0028.15 A

ATOM 4327 CD2 LEU A 544 -33.709-32.340-40.8181.0030.33 A

ATOM 4328 C LEU A 544 -33.880-36.372-394291.0035.59 A ATOM 43290 LEU A 544 -33:066-36.483-38.511 1.0036.79 A

ATOM 4330 N GLN A 545 -34_^855 -37.222-39.6101.0034.97 A

ATOM 4331 CA GLN A 545 -34.966-38.369-38.8041.0034.10 A

ATOM 4332 CB GLN A 545 -36.104-39.207-39.2471.0036.14 A

ATOM 4333 CG GLN A 545 -37.387-38.539-39.3871.0039.28 A ATOM 4334 CD-GLN A 545 -38.515-39.393-38.9281.0041.95 A

ATOM 4335 OElGLNA 545 -39.461 -38,930 -J8.3561.0042.64 A

ATOM 4336-NE2-GLNA545 -38.402-40.646 -39.1521.0044.Q0 A

ATOM -4337 C GLN A 545 -33.810-39.258-38.6421.0032.73 A

ATOM 4338-0 JJLN A 545 -33.933. -40.249 -?8_;Q341.0032.74 A ATOM 4339 N ALA A 546 -32.687-387957-39.2071.0031.78 A

ATOM 4340 CA ALA A 546 -31.499^~-39:803 -39.098 LOO 31.70 A

ATOM 4341 CB- ALA A 546 -30.780-39.866-40:448 1.0032.23 A

ATOM 4342 C ALA A 546 -30.511-39.382-38.001 1.0032.11 A

ATOM 4343 O ALA A 546 -29.747-40.215-37.4961.0030.61 A ATOM 4344 N GLY A 547 -30.513-38.097-37.6441.0031.92 A

ATOM 4345 CA GLY A 547 -29.604-37.611-36.620 1.0032.99 A

ATOM 4346 C GLY A 547 -28.161-37.989-36.9021.0034.11 A

ATOM 43470 GLY A 547 -27.674-37.748-37.9971.0036.15 A

ATOM 4348 N SER A 548 -27.473-38.577-35.9251.0034.90 A ^₁ ,

214

ATOM 4349 CA SER A 548 -26.078-38.985-36.1001.0035.56 A

ATOM 4350 CB SERA 548 -25.237-38.553-34.9001.0035.52 A

ATOM 4351 OG SER A 548 -23.897-38.961-35.0471.0040.49 A

ATOM 4352 C SER A 548 -25.992-40.500-36.2061.0035.33 A ATOM 4353 O SERA 548 -24.903-41.065-36.091 1.0035.14 A

ATOM 4354 N SER A 549- -27.136-41.154-36.408 1.0035.30 A

ATOM 4355 CA SERA 549 -27.191-42.614-36.5021.0035.97 A

ATOM 4356 CB SER A 549 -28.642-43.068-36.6251.0035.82 A

ATOM 4357 OG SERA 549- -29.026 -43.161^" -37.9841.0037.19 A ATOM 4358 C SER A 549 -26.373-43.159-37.6791.0037.05 A

ATOM 4359- O SER A 549 -25.585-44.098-37.5171.0037.43 A

ATOM 4360 N ARG A 550 -26.516 -42:567 -38.851 1.0036.97 A

ATOM 4361 CA ARG A 550 -25.850-42.961-40.073 1.0034.91 A

ATOM 4362 CB ARG A 550 -26.917-42.895-41.111 1.0036.08 A ATOM- 4363 CG ARG-A 550 -27.291-44.110-41.791 1.0037.62 A

ATOM 4364 CD ARG A 550 -28.712-44.164-42.083 1.0039.72 A

ATOM 4365 NE ARG A 550 -29.083-43.597-43.3651.0042.07 A

ATOM 4366 CZ ARG A 550 -28.629-43.984-44.533 1.0043.03 A

ATOM 4367 NHl ARG A 550 -27.767-44.953-44.6321.0041.88 A ATOM 4368 NH2 ARG A 550 -29.042 -43.357 -45.608 Ii)O 41.87 A

ATOM 43.69 C ARG A 550 -24.826-41.910-40.4361.0033.07 A

ATOM.4370- O ARG A 350 -25.024-40.800-40.0241.00.33.25 A

ATΘM- 437LN FROA551- -23.790 -42.238 -4L237 l.θΘ 30.88 A

ATOM-4372 CD PRO A 551- -23.413-43.637-41.5-12 1.0029-.57 A ATOM 4373 -CA PRO Ar5-51 -22L728 -41.326 -41.694 1.0029.44 A

ATOM 4374 CB PRO A 551 -21.768-42.255-42:4271.0027.57 -A

ATOM 43-7.5 CG PRO A 554 -21.922 -43.533: -41.705 1.0028.24 A

ATOM -4376 C PRO A 551 -23.330-40.265-42.6381.0030.00 A

ATOM 4377 O PRO A 55-1 -24.123-40.596-43.525 1.0029.79 A ATOM 4378 N TRP A 552 -22.956-39.001-42.4641.0D30.il A

ATOM 4379 CA TRP A 552 -23.517-37.959-43.3071.0030.55 A

ATOM 4380 CB TRP A 552 -22.907-36.590-42.9921.0030.80 A

ATOM 4381 CG TRP A 552 -21.430-36.407-43.2771.0031.69 A

ATOM 4382 CD2 TRP A 552 -20.836-35.948-44.5061.0032.33 A ₉₁ ,

215

ATOM 4383 CE2TRPA552 -19.444-35.829-44.2801.0030.88 A

ATOM 4384 CE3 TRP A 552 -21.345-35.625-45.775 1.0031.15 A

ATOM 4385 CDl TRP A 552 -20.399-36.550-42.3901.0032.16 A

ATOM 4386 NEl TRP A 552 -19.206 -36.199 -42.982^" 1.0031.05 A ATOM 4387 CZ2 TRP A 552 -18.5.60-35.402-45.272 1.0029.55 A

ATOM 4388 CZ3 TRP A 552 -20,463-35.203-46.7571.0028.79 A

ATOM 4389 CH2TRPA552 -19.087-35.096-46.500 1.0028.84 A

ATOM 4390 C TRP A 552 -23.282-38.302-44.758 1.0032.02 A

ATOM 4391 O TRP A 552 -24473-3-8.167-43.6041.0032.80 A ATOM 4392 N GLN A 553 -22.171-38.913-45.020 1.0032.51 A

ATOM 4393 CA GLN A 553 -21.772-39.118-463471.0032.3« A

ATOM 4394- CB GLN A-553. -20.35S -39.527 -46.3271.0029.30 A

ATOM 4395 CG GLN A 553 -19.774-39.316-45.079 1.0029.37 A

ATOM 4396 CD GLN A 553 -1-8.381 -39.023 -45.1591.0031.64 A ATOM 4397 OEl GLN A 553 -17.970-387134-45.81S 1.0033.64 A

ATOM 4398 NE2 GLN A 553 -17.633-39.712-44.440 1.0032.32 A

ATOM 4399 C GLN A 553 -22.615-40.121-47.0061.0034.38 A

ATOM 4400 O GLN A 553 -22.602-40.200-48.1591.0036.53 A

ATOM 4401 N GLUA 554 -23.381-40.888-46.2501.0035.52 A ATOM 4402 CA GLU A 554 -24.466-41.751-46.7391.0035.47 A

ATOM 4403 CB GLUA-554 -24.577-43.005-45,8761.0035.47 A

ATOM 4404 CG GLU A 554 --23.670-44.134-46.307- 1.0037.05 A

ATOM 4405 CD GLU A 554 -23.624M5.267 -45.293 LOΘ-38.51 A

-ATOM 4406 OEl GLOA-554 _^24:677-45.565-44.6691.0038.37 it ATOM 4407 OE2 GLU A 554 -22.533 -45.865 -45.132 LOO 38.33 A

ATOM 4408 C GLUA 554 -25.824-41.055-46.775 1.00u34:92- A

ATOM^" 4409-O GLU A 554 -26.534-41.106-47.775 1.0035.11 A^"

ATOM -44L0 N VAL A 555 -26.1-87-40.413-45.674 1.00-33.96 A

ATOM 4411 CA VAL A 555 -27.456-39.710-45.604 1.0033.42 A ATOM 4412 CB VAL A 555 -27.607-39.033-44.2441.0032.99 A

ATOM 4413 CGl VAL A 555 -29.044-38.602-44.031 1.0033.19 A

ATOM 4414 CG2 VAL A 555 -27.157-39.989-43.161 1.0033.03 A

ATOM 4415 C VAL A 555 -27.513-38.662-46.7141.0033.13 A

ATOM 4416 O VAL A 555 -28.586-38.274-47.1721.0031.30 A ATOM 4417 N LEUA 556 -26.341-38.208-47.143 1.0033.88 A

ATOM 4418 CA LEUA 556 -26.262-37.223-48.213 1.0034.54 A

ATOM 4419 CB LEUA 556 -24.878-36.556-48.228 1.0030.87 A

ATOM 4420 CG LEU A 556 -24.660-35.441-49.257 1.0026.08 A ATOM 4421 CDl LEU A 556 -25.774-34.418-49.1591:0023.27 A

ATOM 4422 CD2 LEU A 556 -23.317 -34.789 -49.015 1.0025.07 A-

ATOM 4423 C LEU A 556 -26.538-37.914-49.5571.0036.26 A

ATOM 4424 O LEUA 556 -27.387-37.463-50.3361.0036.12 A

ATOM 4425^* N LYSA 557 -25.833-39.017-49.8181.0037.08 A ATOM 4426 CA LYS A 557 -26.021 -39.753 -51J0601.0037.81 A

ATOM 4427 CB LYS-A 557 -25.208-41.046-51.051 1.0038.58 A

ATOM 4428 CG LYS A 557 -25.098 -4.L700 -52.427- LOO 40.17 A

ATOM 4429 CD LYS A 557 -23.977-42.730-52.466 1.0040.16 A

ATOM 4430 CE LYS A 557 -23.497-42.963-53.883 1.004QJ05 A ATOM 4431 ΕZ LYS A 557 -22.163 -43.630 -53.89S 1.0041.51- A

ATOM 4432 C LYS A 557 -27.496-40.069-51.285 1.0038.35 A

ATOM 4433 O LYS A 557 -28.039-39.751-52.3361.0039.42 A

ATOM 4434 N ASP A 558 -28.149-40.685-50.3041.0038.40 A

ATOM 4435 CA ASP A 558 -29.567-41.009-50.436 1.0038.70 A ATOM 4436 CB ASP A 558 -30.138 -41.530 -49.113 1.0041.45 A

ATOM 4437 CG ASP A 558 -29^797-42.988-48.8541.00.43.30 A-

ATOM 4438 ΘD1 ASP A 558 -28:601-43.347-48.909 1.0043.83- A ATOM-.4439 OD2 ASPA 558- -30.72ft -#7781-48.584 ϊ-0045.51 A

-ATOM 4440 C .ASP A 558-- -30378-39.793-50.862 i.003289- A - ATOM- 4444 O ASP A 558 -3-1.229-39.878 -51.7391.00^"39,H- A

ATOM 4442 -N^META 559- -30.101 -38:651 -5TT.2-52 1Λ0-T6.74 A

ATOM 4443 CA MET A 559 -30.857 -37.45r~50.563 1.0Q-36.08 A

ATOM 4444 CB MET A 559 -30.832. -36.493 -49.3721.0035.23 A

ATOM 444.5 CG. MET A 559 -31.526-35.184-49:641 1.0033.32 A ATOM 4446 SD MET A 559 -30.816-33.837-48.703 1.0034.42 A

ATOM 4447 CE MET A 559 -32.264-32.714-48.592 1.0034.45 A

ATOM 4448 C MET A 559 -30.439-36.678-51.7991.0036.27 A

ATOM 4449 O MET A 559 -31.290-36.214-52.541 1.0037.04 A

ATOM 4450 N VAL A 560 -29.140-36.514-52.015 1.0036.42 A ATOM 4451 CA VAL A 560 -28.679-35.737-53.1571.0036.76 A

ATOM 4452 CB VAL A 560 -27.699-34.646-52.693 1.0037.57 A

ATOM 4453 CGl VAL A 560 -27.073-33.930-53.8921.0039.11 A

ATOM 4454 CG2 VAL A 560 -28.444-33.648-51.8291.0037.61 A ATOM 4455 C VAL A 560 -28.054-36.538-54.2941.0037.22 A

ATOM 44560 VAL A 560 -28.033-36.085-55.4371.0037.49 A

ATOM 4457 N GLYA 561 -27.558-37.729-53.993 1.0037.69 A

ATOM 4458 CA GLYA 561 -26.957-38.537-55.033 1.0037.89 A

ATOM 4459 C GLY A 561 -25.451-38.397-55:033 1.0039.63 A ATOM 4460 O GLYA 561 -.24.759-38.963-55.8841.0039.91 A

ATOM 4461 N LEU A 562 -24.929 -37.648 -54:069 IJOO 40.38 A

ATOM 4462 CA LEU A 562 -23.490 -3-7.453 -53.995 LOΘ 40.49 A

ATOM 4463 CB LEU A 562 -23.141-35.996-54.281 1.0040.15 A

ATOM 4464 CG LEU A 562 -22.278-35.771-55.5221.0038.21 A ATOM 4.465 CDl LEU A 562 -22.013 -34.279 -55.6721.0Θ 38.58 A

ATOM 4466 CD2 LEU A 562 -20.974 -36.53O -55.3971.0037.81 A

ATOM 4467 C LEU A 562 -22.847-37.876-52.6821.0040.88 A

ATOM 4468 O LEU A 562 -23.404-37.703-51.6041.0041.96 A

ATOM 4469 N ASP A 563 -21.651-38.430-52.8081.0041.70 A ATOM 4470 GA ASP A 563 -20.858-38.897-51.6851.0041.52 A

ATOM 4471 CB ASP A 563 -19.703-39.747-52.2061.0044.46 A

ATOM 4472 CG ASP AJ563 -19.740-41.162-51.6901.00:47.87 A

ATOM 4473 ODl ASP A563 ,20.654-41.918-52:094 1.00-50.42 A

ATΘM 4474-OD2.ASPA563 -18.850 -41.52L-50.882 1.005O712^" A ATOM 4475 C ASP A 5353 -20^61-37.745-50.875 1.0040.90 A

ATOM 4476 O ASP A 563 -19.759 -37:974--49:783 -1.00-4Θ.76 A

ATOM 4477 N ALAAJ564 -20.30S-3632O -51.4041.0040.56 A

ATOM 4478 CA ALA A 564 -19.720-35.392-50.6841.0040.46 A

ATOM 4479 CB ALA A 564 -18.222-35.411-50.848 1.0040.73 A ATOM 4480 C ALA A 564 -20.222-33.998-51.0471.0040.57 A

ATOM 4481 O ALA A 564 -21.196-33.846-51.793 1.0041.16 A

ATOM 4482 N LEUA 565 -19.545-32.986-50.493 1.0039.99 A

ATOM 4483 CA LEU A 565 -19.867-31.577-50.7461.0039.32 A

ATOM 4484 CB LEU A 565 -19.061-30.667-49.8241.0039.32 A ATOM 4485 CG LEU A 565 -19.600-30.446-48.4171.0038.64 A

ATOM 4486 CDl LEUA 565 -18.531-29.822-47.5481.0036.75 A ^l

ATOM 4487 CD2 LEU A 565 -20.821-29.561-48.493 1.0038.36 A

ATOM 4488 C LEU A 565 -19.535-31.249-52.193 1.0039.34 A ATOM 4489 O LEU A 565 -18.527-31.709-52.729 1.0039.75 A

ATOM 4490 N ASP A 566 -20.383-30,446-52.819 1.0039.00 A

ATOM 4491 CA ASP A 566 -20.205-30.087-54.218 1.0038.57 A

ATOM 4492 CB ASP A 566 -21.020-31.047-55.0991.0041.07 A

ATOM 4493 CG ASFA 566 -20.621 -30.991 -56.573 1.0043.49 A ATOM 4494 ODl ASP A 566 -19.428-31.235-56.8751.0045.98 A

ATOM 4495 OD2ASPA566 -21.500-30.719-57.4291.0042.49 A

ATOM 4496 C ASP A 566 -20.684-28.666-54.421 1.0037.25 A

ATOM 44970 ASP A 566 -21.771-28.294-53.971 1.0036.53 A

ATOM 4498 N ALA A 567 -19.874-27.865-55.100 1.0036.23 A ATOM 4499 CA ALA A 567 -20.249-26.478 -55.345 1.0036.56 A

ATOM 4500 CB ALA A 567 -19.020-25.586-55.3201.0035.28 A

ATOM 4501 C ALA A 567 -20.980 -26.318 -56.6701.0036.76 A

ATOM 4502 O ALA A 567 -21.542-25.257-56.9461.0037.78 A

ATOM 4503 N GLN A 568 -20.876-27.308-57.4981.0036.41 A ATOM 4504 CA GLN A 568 -21.680-27.373-58.6451.0037.22 A

ATOM 4505 CB GLN A 568 -21.602 -28.7J6 -59.2571.0040.15 A

ATOM 4506 CG GLNA 56& -20.424-28.904-602201.0046.32 A

ATOM 4507 CD GLN-A 568 -20.439 -30rl85-61.0661.0049.52 A

ATOM 45Θ8 OEl GLN A 568 -1-9.679 -30.298-61:998 1.0051.19 A ATOM- 4509 NE2 GLN A 568 =21.291-31.111 -60.7521.00-49J-8 A

ATOM- 4510 C GLN A 568 -233)57-26.835-58.5771.0035.58 A

ATOM- 4511 O GLN A 568 -23.371-25.974-59.261 1.00-35:56 A

ATOM 4512 N PROAΛ69 -23.922-27.381-57.7961.003337 A

ATOM 4513 CD PRO A 569 -23.674-28.464-56.833 1.0032.71 A ATOM 4514 CA PRO A 569 -25.308-26.910-57.6991.0031.89 A

ATOM 4515 CB PRO A 569 -25.954-27.919-56.748 1.0030.76 A

ATOM 4516 CG PRO A 569 -24.837 -28.303 -55.8781.0032.42 A

ATOM 4517 C PRO A 569 -25.424-25.472-57.211 1.0030.38 A

ATOM 4518 O PRO A 569 -26.486-24.856-57.3171.0030.62 A ATOM 4519 N LEU A 570 -24.323-24.943-56.685 1.0028.88 A

ATOM 4520 CA LEU A 570 -24.276-23.572-56.184 1.0027.54 A

ATOM 4521 CB LEUA 570 -23.195-23.463-55.0941.0028.82 A

ATOM 4522 CG LEU A 570 -22.585-22.122-54.6771.0028.45 A ATOM 4523 CDl LEU A 570 -23.635-21.047-54.5971.0029.24 A

ATOM 4524 CD2LEUA570 -21.910-22.297-53.338 1.0030.17 A

ATOM 4525 C LEU A 570 -23.975-22.647-57.351 1.0025.68 A

ATOM 4526 O LEU A 570 -24.564-21.580-57.4901.0024.41 A

ATOM 4527 N LEUA 571 -23.055-23.088-58.1981.0025.15 A ATOM 4528 CA LEU A 571 -22.647 -22.344 -59.3791^".OO 24.44 A

ATOM 4529 CB LEU A 571 -21.480-23.076-60.0401.0023.38 A

ATOM 4530 CG LEU A 57-1 -20.314-23.285=59.071 1.0021.69 A

ATOM 4531 CDl LEU A 571 -19.214-24.082-59.734 1.0022.99 A

ATOM 4532 CD2 LEU A 571 49.787-21.936-58.613 1.0018.93 A ATOM 4533 C LEUA57F -23.835-22.232-60.3291.0024.74. A

ATOM 4534 O LEU A 57-1 -24.047-2 L200 -60.9661.0023.72 A

ATOM 4535 N LYS A 572 -24.608-23.309-60398 1.0025.06 A

ATOM 4536 CA LYS A 572 -25.802-23.381-61.225 1.0025.39 A

ATOM 4537 CB LYS A 572 -26.33-1-24,820-61.2121.0025.47 A ATOM 4538 CG LYS A 572 -27797-24.985-61.6121.0026.69 A

ATOM 4539 CD LYS A 572 -28.360-26.323-61,121 1.0029.14 A

ATOM 4540 CE LYS A 572 -27.823 -27.513 -61.8991.0.030.91 A

ATOM 4541 NZ LYS A 572 -28.763-27.923-62:9861.003L97 A

ATOM 4542 C LYS.A 572. -26.875-227417-60.703 1.0026.09- A ATOM 4543 O LYS A 572 -27.677-21.889-61.4691.00-25-4.0 -A

ATOM- 4544 N TYR A373 -26v890 -22.191 -59:394 l.Oβ'26.62 A

ATOM 4545 CA- TYR A 573 -27.869 -21.291--58:8041.0027.18 A

ATOM 4546 CB TYR-A 573 -27.796-21.336-572121.002646 A

ATOM 4547 CG TYR A 573 -28.849-20.499-56.5601.0024.43 A ATOM 4548 CDl TYRA 573 -30.057-21.064-56.1471.0023.61 A

ATOM 4549 CEl TYR A 573 -31.050-20.284-55.5571.0022.31 A

ATOM 4550 CD2 TYRA 573 -28.664-19.129-56.3561.0023.50 A

ATOM 4551 CE2TYRA573 -29.651-18.343-55.771 1.0022.00 A

ATOM 4552 CZ TYRA 573 -30.840-18.924-55.376 1.0022.66 A _9?n

220

ATOM 4553 OH TYR A 573 -31.826-18.142-54.8141.0021.99 A

ATOM 4554 C TYR A 573 -27.621-19.860-59.272 1.0028.87 A

ATOM 4555 O TYR A 573 -28.519-19.211-59.8061.0030.92 A

ATOM 4556 N PHE A 574 -26.399-19:378-59.0721.0029.72 A ATOM 4557 CA PHE A 574 -26.075 -17.980 -59.3341.003L82 A

ATOM 4^"558,CB PHE A 5-74 -24.916 -17.524 -58.4461.0030.39 A

ATOM 4559 CG PHE A 574 -25.277-17.400-56.993 1.0029.94 A

ATOM 4560 CDl PHE A 574 -24.958-18.408-56.098 1.0029.90 A

ATOM 4561 CD2PHEA574 -25.937-16.277-56.523 1.0029.44 A ATOM 4562 CEl PHE A 574 -25.290-18.297 -54.761 1.0029.15 A

ATOM -4563 CE2 PHE A 574 -26.271-16,.16I -55.1871.0030.19 A

ATOM 4564 CZ PHE A 574 -25.947-17.173 -543€5 1.0030.65 A

ATOM 4565 C PHE A 574 -25.730-17.755-60.803 1.0033.75 A

ATOM 4566 O PHE A 574 -25.151 -16.730 -6U64 1.0033,71 A ATOM 4567 N GLN A 575 -25.949-18:677-61.676 1.0035.97 A

ATOM 4568 CA GLN A 575 -25.174-18.614-62.8861.0037.07 A

ATOM 4569 CB GLN A 575 -25.603-19.614-63.8771.0037.27 A

ATOM 4570 CG GLN A 575 -24.541-20.018-64.7431.0038,94 A

ATOM 4571 CD GLN A 575 -24.519-21.413-64.873 1.0041.24 A ATOM 4572 OEl GLN A 575 -25.528-22.000-65.1121.0042.36 A

ATOM 4573 NE2 GLN A 575 -23.396-21.987-64.678-1.0040.35 A

ATOM 4574 C GLN-A 575 -25.295-17355-63.584 l.OΘ 37.79 A

ATOM 4575 O- GLNA 575 -24.36J -16.904-64.126 1.0037.54 A

ATOM 4576 N PROAτ576 -26.482 -16.8-19-63L:658 1,0038.00 A ATOM -4577 CD PRO A 576 -27.7-62 -17.460-63.310^' 1.0038.94 A

ATOM 4578 -CA PRO A 5-76 -26.66.6 -15.667 -64.545- 1.0036.92 A

ATOM 4579 CB PRβA"576 -28.1-69-15.397-64.450 l.O0-36τ94 A

ATOM 4580-CG PRO A 576 -28.765-16.729-64.1601.0039.57 A

ATOM 45-81 C PRO A 576 -25.883-14.448-64.0661.0036.37 A. ATOM 4582 O PRO A 576 -25.077-13.900-64.8191.0037.47 A

ATOM 4583 N VAL A 577 -26.121-14.034-62.8271.0035.25 A

ATOM 4584 CA VAL A 577 -25.401-12.909-62.243 1.0033.71 A

ATOM 4585 CB VAL A 577 -25.911-12.587-60.8271.0033.58 A

ATOM 4586 CGl VAL A 577 -25.383-13.603-59.825 1.0033.24 A _m

ATOM 4587 CG2 VAL A 577 -25.512-11.175-60.425 1.0033.14 A

ATOM 4588 C VAL A 577 -23.902-13.187-62.183 1.0032.37 A

ATOM 45890 VALA577 -23.089-12.263-62.1941.0031.50 A

ATOM 4590 N THRA 578 -23.545-14.465-62.118 1.0030.79 A ATOM 4591 CA THR A 578 -22.137-14.874-62.112 1.0030.70 A

ATOM 4592 CB THR A 578 -21.972-16.415-62.088 1.0032.00 A

ATOM 4593 OGl THR A 578 -22.225-16.912-60.7691.0032.60 A

ATOM 4594 CG2 THR A 578 -20.553-16.811-62.523 1.0031.30 A

ATOM 4595 C THR A 578 ^21.456 -14.386 -63.377 LOO 29.66 A ATOM 4596 O THRA 578 -20.321-13.907-63.3601.0029.88 A

ATOM 4597 N GLNA^~579 -22.157-14.538-64.4851.0028.21 A

ATOM 4598 CA GLN A 579^' -21.623 -1-4.H8 -65.7551.0027.07 A

ATOM 4599 CB GLN A 579 -22.349-14.848-66.881 1.0028.54 A

ATOM 4600 CG GLN A 579 -21.443-15.711-67.7541.0030.37 A ATOM 4601 CD- GLN A 579 -20.793-16.840-66.9891.0031.95 A

ATOM 4602 OEl GLN A 579 -21.475-17.666-66.361 1.0031.51 A

ATOM 4603 NE2 GLN A 579 -19.465-16.892-67.041 1.0032.32 A

ATOM 4604 C GLN A 579 -21.802-12.615-65.893 1.0026.12 A

ATOM 4605 O GLN A 579 -20.938-11.931-66.4351.0026-25 A ATOM 4606 N TRP A 580 -22.920-12.106-65.3801.Θ.025.28 A

ATOM 4607. CA TRP A 580 -2β,231 -10:680-65.454 LQQ 24.40 A

ATOM 4608 CE TRP A 580 -24.592-10.388 -64.837 LOO 25.33 A

ATOM 4609 CG TRP-A 580 -24.967 --8:939-64.925 1.0025.88 A

ATOM -46iO CD2-TRP A 580 -24.711 -7.931 -63τ947 LQO 27.17 A ATOM 4611 €E2-TRPA580 -25.f95 -6.708 -64.47r 1.0026.50- A

-ATOM -4612 CE3 TRP A 580 -24.147 -7.936-62.6821.0027.87 A

ATOM 4613 CDI TRP_A_58G- -25.579 -8.312 -65:970^ 1.0025.36 A

ATOM 4614 NEl TRPA 58O -25.721 -6.971-65.7071.0025.53 A

ATOM 4615 CZ2 TRP A 580 -25.1-09- -5.511 -63.775 1.0026.77 A ATOM 4616 CZ3 TRP A 580 -24.030 -6.747-61.991 1.0029.98 A

ATOM 4617 CH2 TRP A 580 -24.523 -5.546-62.541 1.0029.15 A

ATOM 4618 C TRP A 580 -22.199 -9.817-64.7591.0024.40 A

ATOM 4619 O TRPA 580 -21.709 -8.846-65.3361.0024.06 A

ATOM 4620 N LEU A 581 -21.890-10.154-63.5101.0024.30 A ATOM 4621 CA LEU A 581 -20.906 -9.400 -62.745 1.0022.28 A

ATOM 4622 CB LEUA 581 -20.770 -9.993 -61.338 1.00 19.79 A

ATOM 4623 CG LEU A 581 -21.872 -9.624 -60.341 1.00 16.53 A ATOM 4624 CDl LEU A 581 -21.722 -10.445 -59.071 1.00 11.65 A ATOM -4625 CD2 LEU A 581 -21.79-7 --8.12T -60.051 1.00 13.00^" A

ATOM 4626 C LEU A 581 -19.566 -9.424 -.63.467 1.00 22.52 A

ATOM 4627 O LEUA 581 -18.944 -8.389 -63.694 1.0021.61 A

ATOM 4628 N GLN A 582 -19.104 -10.577-63.779 1.0024.14 A

ATOM 4629 CA GLN A 582 -17.938 -10.790 -64.543 1.00^~26.12 A ATOM 4630 CB GLN A 582 -17.915 -12.253 -64.855 1.0025.87 A

ATOM- 4631 CG GLNA 582 -16.679 -12.958 -64:637 1.09 26.45 A

ATOM 4632 CD -GLN AJ5.82 -16.743 -14.290 -65.071 LOO 27.48 A ATOM 4633 OEl GLNA 582 -15.847 -14.768 -65.605 1.0028.08 A ATOM 4634 NE2 GLN A 582 -17.80444-.905 -64.-853 1.0027.82 A ATOM 4635 C GLN A 582 -17.796 -9.973 -65.764 1.00T7.32 A

ATOM 4636 O GLN A582 -16.756 -9.527 -66.032 1.0028.70 A

ATOM 4637 N GLU A 583 -18.838 -9.833 -66.550 1.00 28.10 A

ATOM 4638 CA GLU A 583 -18.875 -8.973 -67.729 1.00 28.29 A

ATOM 4639 CB GLU A 583 -20.133 -9.254 -68.567 1.00 29.77 A ATOM 4640 CG GLU A 583 -20.277 -8.351 -69.800 1.00 32.20 A

ATOM 4641 CD GLU A 583 -19.-SS9 -8.7.55 -70.982 1.00 33.73 A ATOM 4642 OEl GLU A 583 -18.291 -9329 -78,780 1.0θ^~33Y02 A ATOM^ 4643 OEXGLLLA 583 -19.795 -8ϊ470 -72JL30 1.00 35.04 A

ATOM 4644- C GLTJ A 583 -18.S3Θ- -7.502.^~67.361 1.0027.34 A ATOM 4645 O GLUA583 -18.180 -6τ721-68:041 1.0026.86- -A

A33DM- 4646 N GLNA584 -T9.518 -7.1-35-66.281 1.0027.16- A

ATOM- 4647 CA GbN A 584 -19.570 -5.75Θ -65.813 1.0026.73 A

ATOM 4648 CB GLN A 584- -20.544 -5.612 -64.641 f.OO 26.26 A.

ATOM 4649 CG GLN A 584 -21.998 -5.626 -65.040 .1.0028.23 A ATOM 4650 CD GLN A 584 -22.372 -4.411 -65.864 1.0029.96 A

ATOM 4651 OEl GLN A 584 -22.299 -3.267 -65.387 1.00 29.56 A

ATOM 4652 NE2 GLN A 584 -22.771 -4.645 -67.112 1.00 30.43 A

ATOM 4653 C GLN A 584 -18.228 -5.203 -65.379 1.0026.45 A

ATOM 4654 O GLN A 584 -17.850 -4.093 -65.761 1.0026.75 A „-

223

ATOM 4655 N ASN A 585 -17.510 -5.980-64.573 1.0026.22 A

ATOM 4656 CA ASN A 585 -16.212 -5.539-64.0591.0026.73 A

ATOM 4657 CB ASN A 585 -15.654 -6.538-63.028 1.0026.93 A

ATOM 4658 CG ASN A 585 -16.498 -6.614-61.7691.0025.15 A ATOM 4659 ODl ASN A 585 -16,959 -5.592-61.2661.0024.88- A-

ATOM 4660 ND2 ASN A 585 -16.689 -7.823-61.249 1.0023.32 A

ATOM 4661 C ASN A 585 -15.204 -5.340-65.165 1.0026.33 A

ATOM 4662 O ASN A 585 -14.513 -4.321-65.218 1.0026.21 A

ATOM 4663 N GLN A 586 -15.081 -6.269-66.051 1.0026.16 A ATOM 4664 CA GLN A 586 -14.193 -6.124-67.1701.0026.25 A

ATOM 4665 CB -GLN A 586 -14.357 -7.302-68.0671.0026.28 A

ATOM 4666 CG GLNA 586 -13.187-7.712-68.8371.0028.40- A

ATOM 4667 CD GLN A 586 -13.094 -7.031-70.183 1.0031.43 A

ATOM 4668 OEl GLN A 586 -14.052 -6.867-70.882 1.0030.94 A ATOM 4669 NE2 GLN A 586 -11.934 -6τ666 -70.523 1.0031.92 A

ATOM 4670 C GLN A 586 -14.470 -4.867-67.875 1.0025.95 A

.ATOM 4671 O GLN A 586 -13.668 -4.015-67.918 1.0025.77 A

ATOM 4672 N GLN A 587 -15.631 -4.712-68.4261.0025.45 A

ATOM 4673 CA GLN A 587 -15.850 -3.493-69.192 1.0025.83 A ATOM 4674 CB GLN A 587 -17.312 -3.347-69.6281.0024.59 A

ATOM 4675 CG GLN A 587 -18.125 -4.602.-69.535 1.0025.62 A

ATOM 4676 CD GLNA-587 -19.299 -4.628~70.4971.0025.90 A

ATOM 4677 OEL-GLN-A 587 -19.144 -4,994 -7X656- kθO 28,21 ft

ATOM 4678 NE2 GLNA 587 -20.479- -4.239 -70.021 1.0026.35- A - ATΘM -4679 C GLN A÷587 -15.428 -2.273 -68.3701.0026.63 A

ATOM 46S0 O GLN A 587 -14.654- -1.438 -68.8441.0027.64- A-

ATOM 4681 N ASNA5S8^' -15.911 -2.116-67:1851.00-26.37 A

ATOM 4682 CA ASN A 588 -15.525 -0.994^66.381 LOO 25.51 A

ATOM 4683 CB ASNA58& -16.490 -0.874-65.238 1.0.026:51 A ATOM 4684 CG ASNA 588 -17.773 -0.287-65.620 1.0028.12 A

ATOM 4685 OD1ASNA5S8 -18.003 0.856-65.4701.0029.79 A

ATOM 4686 ND2 ASN A 588 -18.638 -1.082-66.0871.0029.14 A

ATOM 4687 C ASN A 588 -14.129 -1.060-65.833 1.0023.78 A

ATOM 4688 O ASN A 588 -13.815 -0.406 -64.943 1.0024.20 A ATOM 4689 N GLYA 589 -13.290 -1.883-66.369 1.0022.64 A

ATOM 4690 CA GLY A 589 -11.889 -1.967-65.9791.0022.40 A

ATOM 4691 C GLY A 589 -11.493 -2.263-64.542 1.0023.13 A

ATOM 4692 O GLY A 589 -10.353 -1.995-64.150 1.0022,13 A ATOM 4693 N GLU A 590 -12.-409 -2.818-63.7541.0023.77 A

ATOM 4694 CA GLU A 590 -12.114 -3.159-62.358 1.0023.91 A

ATOM 4695 CB GLU A 590 -13.314 -3.869-61.7021.0024.72 A

ATOM 4696 CG GLU A 590 -14.491 -2.967-61.4101.0025.46 A

ATOM 4697 CD GLU A 590^" -14.032 -1.618-60.9101.0027.80 A ATOM 4698 OEl GLU A 590 -13.125 -1.571 -60.0491.0029.68 A

ATOM 4699 OE2GLUA590 -14.572 -0.600_-61.3771.0029.62 A

ATOM 4700- C GLU A 590 -10.891 -4.063-62.2171.0023.01- A.

ATOM 4701 O GLUA 590 -10.376 -4.594-63.198 1.0022.59 A

ATOM 4702 N VALA591 -10.429 -4.220-60.9841.0022.69 A ATOM 4703 CA VAL A 591 -9.299 -5.089-60.6931.0022.33 A

ATOM 4704 CB VAL A 591 -8.105 -4.325-60.0-57 LOO 21.36 A

ATOM 4705 CGl VAL A 591 -6,995 -5.309-59.6871.0020.78 A

ATOM 4706 CG2 VAL A 591 -7.563 -3.303-61,0141.0022.39 A

ATOM 4707 C VAL A 591 -9.777 -6.128-59.682 1.0022.85 A ATOM 4708 O VAL A 591 -10.099 -5.785-58.545 1.0023.91 A

ATOM 4709 N LEU A 592 -9.850 -7.388-60.093 1.0022.75 A

ATOM 4710 CA LEU A 592 -10^73 -8,419-59.1621.0022.24 A

ATOM 4711 CB LEU A S92 -10.523 -9.73S-59.8-95 1.0020.4« A

ATOM 4712 CG LEUA^"592 -1-1.5S4 -9.633 -60.991 UQCL21.02 A ATOM 4713- CDLLEU A-592 -11.820 -11.009 -6L6201.0018.66 A

ATOM 4714 CD2XEUA592 -12.882 T -9.060 -60.412 ΪJΘΪ9.20 A

ATOM 4715 C LEU A 592 -9.154 -8.579 -5=8:134170022.73 A

ATOM 4716 O LEU A 592 -8.013 -8.879-58:4861.002222 A

ATOM 4717 N GLYA 593 -9.493 -8.376-56.866 1.0.Q 23.72 A ATOM 4718 CA GLYA 593 -8.555 -8.599 -55.783 LOO 24.39 A

ATOM 4719 C GLY A 593 -8.060 -7.305-55.1691.0024.68 A

ATOM 4720 O GLYA 593 -8.429 -6.214-55.6061.0024.14 A

ATOM 4721 N TRP A 594 -7.219 -7.430-54.1501.0025.24 A

ATOM 4722 CA TRP A 594 -6.435 -6.307-53.6521.0025.37 A ATOM 4723 CB TRP A 594 -6.699 -6.108-52.1601.0024.18 A

ATOM 4724 CG TRP A 594 -7.074 -7.377-51.4621.0022.76 A

ATOM 4725 CD2 TRP A 594 -8.218 -8.195 -51.7271.0019.95 A

ATOM 4726 CE2TRPA594 -8.168 -9.289-50.840 1.0020.25 A

ATOM 4727 CE3TRPA594 -9.287 -8.-114-52.625 1.0017.34 A

ATOM 4728 CDl TRP A 594 -6.390 -7.993 -50.4541.0022.71 A

ATOM 4729 NEl TRP A 594 -7.042 -9.141-50.073 1.0022.24 A

ATOM 4730 CZ2TRPA594 -9.140-10.287-50.825 1.0017.38 A

ATOM 4731 CZ3TRPA594 -10.250 -9.106-52.609 LOT⁾ 15.83 A

ATOM 4732 CH2 TRP A 594 -10.170 -10.178 -51.7161.0015.40 A

ATOM 4733 C TRP A 594 -4.950 -6.567-53.8821.0026.34 A

ATOM 4734 O TRP A 594 -4.362 -7.453-53.2571.0029.44- A

ATOM 4735 N PRO A 595 -4.346 -5.793-54.7771.0025.15 A

ATOM 4736 CD PRJQ A 595 -5.038 -5.242-55.9561.0024.93 A

ATOM 4737 CA PRQ A 595 -2.890 -5.814-54.9501.0024.29 A

ATOM 4738 CB PRO A 595 -2.707 -5.402-56.413 1.0023.44 A

ATOM 4739 CG PRO A 595 -3.922 -4.608-56.732 LOO 24.1-5 A

ATOM 4740 C PRO A 595 -2.198 -4.814-54.031 1.0024.14 A

ATOM 4741 O PRO A 595 -1.061 -5.041-53.619 1.0023.50 A

ATOM 4742 N. GLU A 596 -2.883 -3Jl 9 -53.715 1.0024.08 A

ATOM 4743 CA GLU A 596 -2.395 -2.770. -52.7221.0023.76 A

ATOM 4744 CB GLU A 596 -2.88« -1.358 -53-.043 1:0023.78 A

ATOM 4745 CG GLU A 596 -2.254 -0.747-54.2821.00-27.03 A

-ATOM 4746. CD -GLU A 596 -2.600 0.719 --54.450- 1.0028.65 A

ATOM 4747 OEl GLU A 5.96 -3.172 1.109-53.5091.00^0.60- A

ATOM 4748 OE2 GLU A-596 -2.30T 1.283-55.5241.0.0-28.49^" A

ATOM 4749- C GLU A 596 -2:830 -3.171-51.3161.0024.12 A

ATOM 4750 O GLUA 596 -3.461) -2.390-50.6031.0023.58 A

ATOM 4751 N TYR A 597 -2.488 -4.394-50.923 1.00-24.18 A

ATOM 4752 CA TYR A 597 -2.719 -4.855-49.551.1.0022.41 A

ATOM 4753 CB TYR A 597 -2.150 -6.267-49.3841.0021.40 A

ATOM 4754 CG TYR A 597 -0.653 -6.297-49.4721.0020.52 A

ATOM 4755 CDl TYRA 597 0.120 -5.914-48.3901.0022.43 A

ATOM 4756 CEl TYR A 597 1.505 -5.852-48.4701.0023.20 A ATOM 4757 CD2 TYRA 597 -0.004 -6.629-50.651 1.0021.96 A

ATOM 4758 CE2TYRA597 1.389 -6.570 -50.745 1.0022.63 A

ATOM 4759 CZ TYR A 597 2.135 -6.180-49.641 1.0022.77 A

ATOM 4760 OH TYR A 597 3.507 -6.127-49.665 1.0021.93 A

ATOM 4761 C TYR A 597 -1.871 -3.844-48.7871.0021.79 A

ATOM 4762 O TYR A 597 -1.057 -3.141-49.3991.0024.79 A

ATOM 4763 N GLN A 598 -2.034 -3.748-47.4771.0020.07 A

ATOM 4764 CA GLN A 598 -1.238 -2.781 -46.7151.0019.86 A

ATOM 4765 -CB GLN A 598 0.215 -2.733 -47.2421.0017795 A

ATOM 4766 CG GLN A 598 1.138 -1.710-46.5741.0019.57 A

ATOM 4767 CD GLN A 598 2.606 -1.839 -47.013 1.00-22.24 A

ATOM 4768 OEl GLN A 598 3.470 -1.096 -46.5561.00-20.34 A

ATOM 4769 NE2GLNA598 2.885 -2.791-47.8981.0024.70 A

ATOM 4770 C GLN A 598 -L-838 -1.379-46.7371.0018.63 A

ATOM 4771 O GLN A 598 -1.391 -0.525 -45.9891.0020.57 A

ATOM 4772 N TRP A 599 -2.840 -1.138-47.581 1.0016.87 A

ATOM 4773 CA TRP A 599 -3.463 0.176-47.6481.001734 A

ATOM 4774 CB TRP A 599 -4.126 0.420-48.9981.0014.85 A

ATOM 4775 CG TRP A 599 -4.924 1.715-49.0381.0013.15 A

ATOM 4776 CD2TRPA599 -6.340 1.870-48.819 1.0012.61 A

ATOM 4777 CE2TRPA599 -6.616 3.253-48.8491.0013.73 A

ATOM 4778 CE3TRPA599 -7.397 0:975 -4S.5961.0012.39 A

ATOM 4779 CDl TRP A 599 -4.429 2.970-49,193 1.0013.43 A

ATOM- 4780- -NEl TRP A 599 -5.-432 3.898 -4:9:080 M)O 13.08 A

ATOM 4781 CZ2 TRP A 599 -7.904 3-.768--48J5641.0010.88 A

ATOM 47-8-2 CZ3 TRP-A 599 -8.683 1.490--4S.411 LOO 12.-53 A

ATOM- 4783 CH2T-RPA599 -8.920 2.875-48 „4461.ΘΘI135 A

ATOM 4784 C TRP A 599 -4,540 0333-46.5871.0021.33 A

ATOM 4785 O TRP A 599 -5.339 -0.586-46.3761.0022.64 A

ATOM 4786 N HIS A 600 -4.576 1.499-45.935 1.0023.11 A

ATOM 4787 CA HIS A 600 -5.589 1.764-44.933 1.0023.61 A

ATOM 4788 CB HIS A 600 -5.015 1.642-43.526 1.0023.42 A

ATOM 4789 CG HIS A 600 -4.704 0.235-43.118 1.0024.52 A

ATOM 4790 CD2 HIS A 600 -5.379 -0.632 -42.325 1.0025.01 A ATOM 4791 NDl HIS A 600 -3.585 -0.441 -43.560 1.0024.98 A ATOM 4792 CEl HIS A 6Θ0 -3.582 -1.663 -43.056 1.0025.67 A ATOM 4793 NE2 HIS A 600 -4.661 -1.804 -42.304 1.00 27.07 A ATOM 4794 C HIS A 600 -6.174 3.145 -45.118 1.0024.86 A. ATOM 4795 O HIS A 600 -5.479 4.086 -45.480 1.0024.64 A ATOM 47-96 N PRO A 601 -7.480 3.281 -44.867 1.0026.30 A ATOM 4797 CD PRO A 601 -8.418 2.255 -44.375 1.0025.90 A ATOM 4798 CA PRO A 601 -8.159 4.563 -45.006 1.0027.16 A ATOM 4799 CB PRO A 601 -9.626 4.170 -44.923 1.0026.61 A ATOM 4800 CG PRO A 601 -9.602 3.080 -43.919 1.0024.21 A ATOM 4801 C PRO-A 601 -7.763 5.463 -43.861 LOO 28.60 A ATOM 4802 O PRO A 601 -7.460 4.985 -42.773 1.0029.64 -A ATOM 4803 N PRO A 602 -7.756 6.780 -44.089 1.0029.79 A ATOM 4804 CD PRO A 602 -7.958 7.416 -45.402 1.00 29.35 A ATOM 4805 CA PRO A 602 -7.406 7.786 -43.079 1.00 30.76 A ATOM 4806 CB PRO A 602 -7.022 8.985 -43.932 1.00 30.16 A ATOM 4807 CG PRO A 602 -7.999 8.884 -45.048 1.0030.18 A ATOM 4808 C PRO A 602 -8.626 8.078 -42.182 1.00 30.93 A ATOM 4809 Θ PRO A 602 -9.755 7.749 -42.544 1.00 30.56 A ATOM 4810 N LEU A 603. -8.449 SL795 -41.109 1.00 31.81 A ATOM 4811 CA LEU A 603 -9.572 8.9.91 -40.277 1.00 33.57 A -ATOM 4812 CB EEU-A 603 -9.163 9.391 -38,904 LOO 33.75 A ATOML 4813 CG LEU A-603 -8.353 8.445 -38.10? LOQ 35.18 A ATOM 4814 CDl LEU A 603 -7:812 9.165 -37:029- 1.00.34,73 A ATOM 4815- CD2EEUA603 -9.256 7.503 -37.588 1.0036.50 A ATOM 4816 C LEUA-6Q3- -10.324 10.089--40J-83 1.00 34.6L A ATOM-^817 O LEU A 603 -9:815- 1-0.867 -41.477 LOO 33.86- A ATOM 48T8 N PRO A 6.04 -11.601 10.1-58 -40.42L 1.00 36.13 A ATOM 4819 CD PRO A 604 -12.419 9.046 -39.906 1.00 37.13 A ATOM 4820 CA PRO A 604 -12.383 11.386 -40.587 1.0038.71 A ATOM 4821 CB PRO A 604 -13.660 11.089 -39.800 1.0037.28 A ATOM 4822 CG PRO A 604 -13.813 9.611 -39.890 1.00 38.37 A ATOM 4823 C PRO A 604 -11.670 12.596 -39.992 1.00 42.28 A ATOM 4824 O PRO A 604 -10.740 12.436 -39.201 1.00 43.26 A ATOM 4825 N ASP A 605 -12.106 13.792 -40.373 1.0046.22 A

ATOM 4826 CA ASP A 605 -11.237 14.963 -40.364 1.0049.85 A

ATOM 4827 CB ASP A 605 -11.967 16.177 -40.941 1.00 52.55 A

ATOM 4828 CG ASP A 605 -11.598 16.447 -427386 1.00 56.03 A ATOM 4:829 ODl ASBA 605 -11.342 15.475 -43.127 1.00 58.27 A

ATOM 4830 OD2 ASP A 605 -11.338 17.597 -42.869 1.00 55.38 A

ATOM 4831 C ASP A 605 -10.741 15.270 -38.955 1.00 50.73 A

ATOM 4832 O ASP A 605 -9.658 15.828 -38.776 1.00 52.03 A

ATOM 4833 N ASN A 606 -11.539- 14.901 -37.959 1.0049.99 A ATOM 4834 CA ASN A 606 -11.482 15.547 -36.653 1.00 49.37 A

ATOM 4835 CB ASNA 606 -12.243 16.874 -36.678 1.00-49.35 A

ATOM -4836 CG ASN A 606 -11.361 18.057 -36.329 1.00 49.40 A

ATOM 4837 OD1 ASN A 606 -10.154 17.911 -36.134 1.0047.80 A

ATOM 4838 ND2 ASN A 606 -11.961 19.239 -36.250 1.00 50.01 A ATOM 4839 C ASN A 606 -1-2.026 14.652 -35.544^" 1.0049.33 A

ATOM 4840 O ASN A 606 -13.010 14.990 -34.887 1.0049.38 A

ATOM 4841 N TYRA 607 -11.378 13.510 -35.341 1.00 48.23 A

ATOM 4842 CA TYR A 607 -12.077 12.288 -34.963 1.0047.20 A

ATOM 4843 CB TYR A 607 -11.829 11.186 -35.995 1.00 43.84 A ATOM 4844 CG TYR A 607 -12.574 9.902 -35.712 1.00 40.46 A

ATOM 4845 CDl TYRLA 607 -13.9-13 9.765 -36.053 1.00 39.31 A

ATOM 4846 CEl TYR A 607 -14τ600 8.594 -35.797 1.00 37.91 A

ATOM 4847 GD2.TYRA-697 -11.940 8.8-27 -35.105- 1.0Θ-39.08 A

ATOM- 4848 CE2 TY=R. A 607^' -12.618 7.651 -34.845 1.003*02: A ATOM 4849 CZ TYRA^~6O7 -13.948 7.540--35:193. 1.00,38.36 A

ATOM 4850 OΪTTYRA=607 -14.628 6.371 -34τ937 l.OQ-38.19 A

ATOM" 4851 C TYRA-6Θ7- -LL.652 11.814 -33.577 1.0049:21 A

ATOM 4852- O TYR A 607 -10.500 1L434 -33.368-1.0049.55 A

ATOM 4853 N PRO A 608 -12.589 11.837 -32^636 1.00 50.72 A ATOM^" 4854 CD PRO A 60S -12.041 10.852 -31.687 1.0050.76 A

ATOM 4855 CA PRO A 608 -13.999 11.579 -32.947 1.00 52.91 A

ATOM 4856 CB PRO A 608 -14.239 10.195 -32.340 1.00 51.54 A

ATOM 4857 CG PRO A 608 -13.259 10.105 -31.224 1.00 50.50 A

ATOM 4858 C PRO A 608 -14.920 12.604 -32.295 1.00 55.88 A _m

ATOM 4859 O PRO A 608 -15.386 12.391 -31.176 1.00 56.24 A

ATOM 4860 N ALA A 609 -15.176 13.705 -32.994 1.00 59.30 A

ATOM 4861 CA ALA A 609 -16.201 14.655 -32.579 1.00 61.97 A

ATOM 4862 CB. ALA A 609 -15.570 15.826 -31.84σ 1.0059.71 A ATOM 4863 C ALA A 609 -17.011 15.151 -33.773 1.0064.52 A

ATOM 4864 0 ALA A 609 -16.555 16.007 -34.532. 1.00.65.49 A

ATOM 4865 N GLYA 610 -18.213 14.607 -33.934 1.00 66.84 A

ATOM 4866 CA GLY A 610 -18.876 14.591 -35.225 1.00 69.46 A

ATOM 4867 C GLY A 610 -20.381 14.561 -35.038 1.00 71.87 A ATOM 4868 O GLYA 610 -20.900 13.044 -34.032 1.00 73.10 A

ATOM 4869 N ALAA 611 -21.081 13.991 -36.013 1.00 73.56 A

ATOM^' 4-870 CA ALA A611 -22:464 13.572 -35.818 1.00 75.56 A

ATOM 4871 CB ALA A 611 -23.315 14.135 -36.946 1.00 75.02 A

ATOM 4872 C ALA A 611 -22.641 12.061 -35.71-9 1.00 76.97 A ATOM 4S73 O ALA A 611 -22.846 11.383 -36.726 1.00 77.36 A

ATOM 4874 N ALA A 612 -22.559 11.539 -34.499 1.00 77.67 A

ATOM 4875 CA ALA A 612 -21.337 10.910 -34.014 1.00 77.73 A

ATOM 4876 CB ALA A 612 -21.669 9.767 -33.067 1.00 76.94 A

ATOM 4877 C ALA A 612 -20.477 10.412 -35.171 1.00 77.77 A ATOM 4878 0 ALA A 612 -19.412 10.965 -35.448 1.00 77.11 A ATOM 4879 ZN+2 ZN2 A 701 -27.749 -21-.950-3&694 1.003.1.55 A

ATOM 4S80 CL CL A 702 -27.997 -18.440 -91.633 LOO 37:15 A

ATOM 4881 CL NAG A 69.1 -2J556- 0.205 ,29.595 k00 42.25 A-

ATOM 4882_C2 NAG-A 691 -1.485 1.001 -29.-153 170.0^41.75 A ATOM -4S83 €3 NAG A 691 -2.114 1.986 -28.304 1.00-43.62 A

ATOM 4S§4- C4-NAG A 691 -2.940 2.962 -28.97L 1.0Θ 45.06 A

ATOM- 488T C5 NAG A 691 -4.088 2.162 -29.383^~ 1:00 44.59- A

ATOM 4886 C6 NAG A 691 -4J770 3J098 -30.312 1.00 44.13 A

ATOM 4887 C7 NAG A 691 -0.347 -0J500 -27.831 1.00 41.96 A ATOM 4888 C8 NAG A 691 -0.334 -1.075 -26.654 1.00 41.29 A

ATOM 4889 N2 NAG A 691 -1.199 0.302 -28.002 1.0041.51 A

ATOM 4890 03 NAGA 691 -1.197 2.696 -27.526 LOO 44.90 A

ATOM 4891 04 NAG A 691 -3.264 3.946 -28.002 1.00 46.21 A

ATOM 4892 05 NAG A 691 -3.686 1.023 -30.082 1.00 43.99 A _23Q

ATOM 489306 NAG A 691 -4.754 4.380-29.685 1.0044.45 A

ATOM 489407 NAGA 691 0.377 -0.980-28.643 1.0043.03 A

ATOM 4895 Cl NAG A 692 -34.269-12.671-13.273 1.0063.56 A

ATOM 4896 C2 NAG A 692 -34..229 -12.631-11.7721.0064.49 A ATOM 4897 C3 NAG A 692 -34.947-13.777-11.168 1.0064.22 A

ATOM 4898 C4 NAG A 692 -36.333-13.672-11.711 1.0063.84 A

ATOM 4899 C5 NAG A 692 -36.280-13.595-13.2161.0062.95 A

ATOM 4900 C6 NAG A 692 -37.605-13.487-13.905 1.0061.07 A

ATOM 4901 C7 NAG A 692 -32270 -13.676 -10.711 1.0064.23 A ATOM 4902 C8 NAG A 692 -32.980-14.689-10.4041.0063.59 A

ATOM 4903 N2 NAG A 692 -32.852 -12.712 -11.363 l.Oϋ 65.15 A

ATOM 4904 O3 NAG A 692 -35.045-13.606 -9.7591.0063.03 A

ATOM 4905 O4 NAG A 692 -36.991-14.825-11.2271.0064.82 A

ATOM 490605 NAG A 692 -35.617-12.414-13.4901.0062.81 A ATOM 4907 O6 NAGA 692 -3-7.828 -12.112 -14.039 l.OΘ 59.24 A

ATOM 4908 O7 NAG A 692 -31.123-13.642-10.443 1.0063.59 A

ATOM 4909 Cl NAG A 693 -34.477-42.696-23.3241.005853 A

ATOM 4910 C2 NAG A 693 -35.699-41.795-23.191 1.0058.49 A

ATOM 4911 C3 NAG A 693 -36.964-42.523-23.6301.0057.95 A ATOM 4912 C4 NAG A 693 -36.768-43.187-24.9871.0058.71 A

ATOM 491 J C5 NAG A 693 -35.481 -44.004-25.016 Lθϋ 58.21 A

ATOM 4914 G6 NAGA 693 -35.246 -44.604 -26.39T 1.0057.18 A

ATOM 49-1-5 C7 NAG A 691 -35.806 -42.666 -20.9091.0060.85 A-

ATOM ^"4916 C8 NAG A 693 -35.964-42315 -19^611 I.røβθJl A AXOM -4917 N2- NAHA 693 -35.^860 -41.586 -21.760 1.00-5-8:86 A

ATOM 4918 -O3 NAG A 693 -38.049-41392 -23.705 1.0056.80" A

ATOM 491904 NAGA 693 -37.882T-44.043 -25.265 l.OΘ-59.25 A^"

ATOM 4920 O5 NAG A 693 -34.379-43.169-24.666 1.6658L94 A

ATOM ^921 O6 NAG A 693 -34.034-45.366-26.386 1.0054.16 A ATOM 492207 NAG A 693 -35.620-43.758-21.263 1.0061.99 A

ATOM 4923 Cl NAG A 694 -39.567-42.058-22.933 1.0068.25 A

ATOM 4924 C2 NAG A 694 -40.705-41.6-87-22.0071.0068.16 A

ATOM 4925 C3 NAG A 694 -41.719-42.766-21.8251.0067.96 A

ATOM 4926 C4 NAG A 694 -42.350-42.900-23.1401.0068.00 A _m

ATOM 4927 C5 NAG A 694 -41.230-43.316-23.993 1.0067.98 A

ATOM 4928 C6 NAG A 694 -41.799-43.349-25.349 1.0068.09 A

ATOM 4929 C7 NAG A 694 -39.966-40.544-20.061 1.0065.37 A

ATOM 4930 C8 NAG A 694 -39.269-40.754-19.058 1.0065.62 A ATOM 4931 N2 NAG A 694 -40.022-41.610-20.774 1.0066.47 A

ATOM 4932. O3 NAGA 694 -42.727-42:236-21.005 1.0067.28 A

ATOM 4933 O4 NAG A 694 -43.327-43.904-23.056 1.0068.33 A

ATOM 493405 NAG A 694 -40.179-42.368-24.135 1.0069.20 A

ATOM 4935 O6 NAG A 694 -40.635-43.547-26.1301.00.68.13 A ATOM 4936 O7 NAG A 694 -40.424-39.468-20.1841.0064.59 A

ATOM 4937 Cl NAG A 695 -15.374-13.838 -13.9941.0067.83 A

ATOM 4938 C2 NAG A- 695 -14.178 -14.613 -13.421 t.OO 67.87 A

ATOM 4939 C3 NAG A 695 -14.382-15.025-11.9561.0067.82 A

ATOM 4940 C4 NAG A 695 -15.Q92 -13.946 -11.1101.0067.67 A ATOM 4941 C5 NAG A 695 -16.291-13-421-11.872 1.0067.30 A

ATOM 4942 C6 NAG A 695 -17.075 -12.361 -11.1471.0067.41 A

ATOM 4943 C7 NAG A 695 -12.804 -16.128--14.7271.0067.19 A

ATOM 4944 C8 NAG A 695 -12.059-17.299-14.106 1.00-66.22 A

ATOM- 4945 N2 NAG A 695 -13.989-15.819-14.208 1.0067.85 A ATOM 494603 NAG A 695 -13.H3 -15.308 -11.3891.0067,82 A

ATOM 494704: NAG A 695 -15.524-14.503 -9.8761.0067.46 A

ATOM 494805. NAG A 695 -15.843-12.847-13.092 1.0066.86 A

ATOM 4949 O6 NAG A 695 -18.e92-LT.833 -11.9S7 LOO 68.27 A

-ATOM 4950 O7 NAG A 695 -12305 -15.522^"-15:6731.00-67.16 A ATOML 4951 Cl NAG A 696 -3r891 5.074 -2ZQ35 1. GO 1.023-5--- A

ASGM. 4952 C2 NAG A 696 -3.388 6J68 -27.1-061.00102.66 A

-ATOM 4953 C3 NAG A 696 -3.831 7.25θ -25..770 L0.01OZ52 A

ATOM 4954 C4 NAG A 696 -5.375 7.216-25.7341.00102.43 A

ATOM 4955 C5 NAG A 696 -5.832 5,693-25.728 1,0010239 A ATOM 4956 C6 NAG A 696 -7.292 5.492-25.676 1.00102.27 A

ATOM 4957 C7 NAG A 696 -1.211 7.219 -28.116 1.00103.23 A

ATOM 4958 C8 NAG A 696 0.233 7.137-27.9921.00102.86 A

ATOM 4959 N2 NAG A 696 -1.925 6.588-27.1391.00103.15 A

ATOM 496003 NAG A 696 -3.384 8.619-25.7881.00102.27 A ,„

232

ATOM 496104 NAG A 696 -5.827 7.839-24.5191.00102.23 A

ATOM 496205 NAG A 696 -5.319 5.086-26.9941.00102.41 A

ATOM 496306 NAG A 696 -7.615 4.171-25.330 1.00102.70 A

ATOM 496407 NAG A 696 -1.709 7.786-28.990 1.00103.24 A ATOM 4965 Cl NAG A 697 -48.304-10.691-31.326.1.00114.89 A

ATOM 4966 C2 NAG A 697 -48.808-10.576-29.8341.00115.54 A

ATOM 4967 C3 NAG A 697 -48.914-12.037-29.285 1.00115.59 A

ATOM 4968 C4 NAG A 697 -49.968-12.768-30.1441.00115.33 A

ATOM 4969 C5 NAG A 697 -49.445 -12.8TC) -31.645 1.00114.98 A ATOM 4970 C6 NAG A 697 -50.343-13.487-32.5921.00115.31 A

ATOM 4971 C7 NAG A 697 -48.076 -8.771-28.2901.00116.10 A

ATOM 4972 C8 NAG A 697 -46.954 -8.212 -27.555 1.0Θ115.13 A

ATOM 4973 N2 NAG A 697 -47.800 -9.883-29.032 1.00115.82 A

ATOM 4974 O3 NAG A 697 -49.364-11.980-27.9201.00115.61 A ATOM 4975 O4 NAG A 697 -50.100-14.120-29.6701.00114.93 A

ATOM 4976 O5 NAGA 697 -49.302-11.378-32.0821.00114.30 A

ATOM 4977 O6 NAG A 697 -4.9.686-13.784-33.7971.00115.94 A

ATOM 497807 NAG A 697 -49.126 -8.294-28.2391.00116.05 A

ATOM 4979 Cl BMA A 900 -44.667 -44.071 -23.041 1.00105.78 A ATOM 4980 C2 BMA A 900 -45.437 -42.905 -22.4 L51.00105.64 A

ATOM 4981 02 BMA- A 900^" -45.349-41.763-23.267 L00105.46- A

ATOM 4952. C3 BMA A900 -4:6.904 -433J09 -22.243 1.00105.88 A

ATOM 4983 O3 BMA A 900 -47.663-42.183-21.7991.00105.67 A

ATOM 4984- C4 BMA A 900 -47.439-43.793-23.596-1.00-106.16 A ATOM 4985 O4 BMA A 900 -48.760-44.312 -23.43« U)0107τ54 A

ATOM.4986- C5 BMA A 900^" -46J19 -44^891 -24.131 LffO-105.89 -A

ATOM 4987 C6 BMA A 900 -4.7.065-45.407-25.465 1.00104.97 A

ATOM 4988 O6 BMA A 900 -46.210-46.437=25.965 1.00104.32 A

ATOM 4989 O5 BMA A 900 -45.207-44.371-24.325 1.00105.59 A ATOM 4990 C ACT A 800 -1.026-18.401-40.484 1.0054.57 A

ATOM 4991 O ACT A 800 -0.975-17.772-41.626 1.0054.77 A

ATOM 4992 OXT ACT A 800 -0.105-19.110-39.954 1.0055.42 A

ATOM 4993 CH3ACTA800 -2.356-18.236-39.753 1.0051.84 A

ATOM 4994 Cl GOLA2433 -11.417 -6.356-73.980 1.0028.25 A ATOM 4995 Ol GOLA2433 -10.614 -5.261-74.2221.0026.33 A

ATOM 4995 C2 GOLA2433 -12.311 -6.641-75.118 1.0028.99 A

ATOM 499702 GOL A2433 -13.475 -7.164-74.711 1.0028.06 A

ATOM 499-8 C3 GOLA2433 -12,73.7 -5.379-75.637 1.0030.22 A ATOM 499903 GOL A2433 -13.346 -5.606-76.838 1.0.027.87 A

ATOM 5000 Cl GOLA2434 -6.493-11.083-54.5201.0033.16 A

ATOM 5001 Ol GOLA2434 -5.388-10.288-54.300 1.0035.07 A

ATOM 5002 C2 GOL A2434 -6.772-11.964-53.371 1.0033.47 A

ATOM 500302 GOL A2434 -7.311-13.127-53.761 1.0031.95 A ATOM 5004 C3 GOL A2434 -5.507 -12.397 -52.8641.0034.38 A

ATOM -5O0503 GOLA2434 -5.724~12.994 -51.655 LOG 29.91 A

ATOM 5006- C ACTA 801 -23.630-15.606-37.5701.0039.60 A

ATOM 5007 O ACTA 801 -22.537-16.066-38.1171.0038.76 A

ATOM 5008 OXT ACT A 801 -23.875 -14.398 -37.239 -1.0α40.11 A ATOM 5009 CH3 ACT A 801 -24.6S9 -16.678 -3X326 1.0017.10 A

ATOM 5010 C ACTB 801 -16.292-23=491-90.598 1.0055.71 B

ATOM 5011 O ACTB 801 -15.020-23.630-90.853 1.0056,05 B

ATOM 50L2 OXT ACT B 501 -16.906-22.409-90.3071.0055.98 B

ATOM 5013 CH3 ACTB 801 -17.077-24.798-90.6721.0054.50 B ATOM 5014ZN+2ZN2B701 -22.723 -27.770 -91.5931.0029.74 B

ATOM 5015 -CL CL B 703 -18.098-27.730-36.933 1.0030.54 B

ATOM- 5016 N -ALAB 2 -38_^012 -2&571-119rS121.005235 B^"

ATOM 5G-W GAALAB 2 -39.222-26.174-120.521 1.0052.71 B

ATOM 5018 CB ALAB 2 -39.77G -24.876-119.9471.00:51:48 B ATOM 5019 C ALA-B 2 -40.280 -27.271-120.466 1.0053J55 B

ATOM 5O20: O ALA-B 2 -39.956 -28.452-120.343 l.θθ-52.07 B

ATOM 5021 N PRO=B 3 -41.544-26:872-120.5591.00-55.09- B

ATOM 502-2 CD PROB 3 -41.623.-25.599-121.2961.0054.55 B

ATOM- 5023 CA PRO B 3 -42.618-27.797-120.9371.0055.17 B ATOM 5024 CB PROB 3 -43.441.-26.985-121.941 1.0054.73 B

ATOM 5025 CG PROB 3 -42.498-25.955-122.4571.0054.66 B

ATOM 5026 C PROB 3 -43.483-28.179-119.7401.0054.78 B

ATOM 5027 O PROB 3 -44.118-27.313-119.1381.0053.82 B

ATOM 5028 N GLYB 4 -43.503-29.465-119.405 1.0054.86 B ATOM 5029 CA GLYB 4 -44.281-29.947-118.2791.0055.34 B

ATOM 5030 C GLYB 4 -44.103-28.934-117.165 1.0055.83 B

ATOM 5031 O GLYB 4 -44.991-28.750-116.3321.0056.40 B

ATOM 5032 N LEUB 5 -42.950-28.274-117.150 1.0055.59 B ATOM- 5033 CA.LEUB 5 -42.434-27.659-115.933 1.0053.55 B

ATOM 5034 CB LEUB 5 -40.945-27.474-116.2301.0049.69 B

ATOM 5035 CG LEUB 5 -40.081-28.736-116.1771.0048.03 B

ATOM 5036 CDlLEUB 5 -38.603-28.378-116.2001.0046.32 B

ATOM 5037^" CD2 LEUB 3 -40.417 -29.566-114.9481.0Θ 47.27 B ATOM 5038 C LEUB 5 -43.043-267342-115.4661.0053.87 B

ATOM 5039 O LEUB 5 -42.473^"-25,646--114.626 1.Θ054.92 -B

ATOM- 5040 N GLNB 6 -44.205 -.26.005-116.0171:0054.78 B

ATOM 5041 CA GLNB 6 -44.722-24.688-115.921 1.0055.58 B

ATOM 5042 -CB GLNB 6 -45.062-24.190-117.2801.0055.83 B ATOM 5043 GG GLNB 6 -43.999-23.475-117.913 1.0056.58 B

ATOM 5-Q44 CD GLNB 6 -43.947-23.741-119.3281.0057.43 B

ATOM 5045 OElGLNB 6 -44.435-22.971-120.1101.0058.66 B

ATOM 5046 NE2 GLN B 6 -43.352-24.838-119.6961.0057.55 B

ATOM 5047 C GLNB 6- -45.947-24.761-115.151 1.0056.30 B ATOM 5048 O GLNB 6 -46.575-25.767-115.0991.0055.49 B

ATGM^" 5049- N ERO-B 7 -46.298-23.664-114.5441.0057.56 B

ATOM 5050 CD EROB T -45.535-22.411-114.3861.005-7.46 JB

ATOM -5&51 CA .PRO B 7 -47.528-23.624-113.759 lJOO 55.00 B

AXQM- 5052TCB PRO B 7 -47.292-22.443-112:825-1.0058:23 B ATOM^" 5G53 -CG- PRO B 7 -46:531 -21.5.05-113.6961.0057.87 B

ATOM 15054^" -C PROB 7 -48.813--23.474-114.5641:0060.29 B

ATOM 5Θ55 O PJROB 7 -49:064-22.42^115.-1701.0059.73 -B

ATOM 5056 N GLYBT 8 -49.621-24.530-114.569 1.0061.70 B

ATOM 5057 CA GLYB 8 -50,889-24.469-115.260 1.0062.99 B ATOM 305« C GLYB 8 -51.685-23.407-114.532 1.0064.39 B

ATOM 5059 O GLYB 8 -51.243-22.903-113.5001.0065.52 B

ATOM 5060 N ALAB 9 -52.854-23.068-115.0661.0065.21 B

ATOM 5061 CA ALAB 9 -53.715-22.064-114.4521.0065.89 B

ATOM 5062 CB ALAB 9 -54.630-21.441-115.4951.0065.51 B ATOM 5063 C ALAB 9 -54.533-22.662-113.3121.0066.35 B

ATOM 5064 O ALAB 9 -55.752-22.797-113.414 1.0067.27 B

ATOM 5065 N PHEB 10 -53.854-23.018-112.227 1.0066.12 B

ATOM 5066 CA PHEB 10 -54.527-23.493-11-1.0241.0065:35 B ATOM 5067 CB PHEB 10 -53.503-23:911-109.9661.0061.40 B

ATOM 5068 CG PHEB 10 -52.683-25.108-110:3561.0037-57 B

ATOM 5069 CDlPHEB 10 -51.410-24.951-110.8791.0055.45 B

ATOM 5070 CD2PHEB 10 -53.184-26.389-110.2001.0056.75 B

ATOM 5071 CElPHEB 10 -50.653-26,050-111.2391.0055.89 B ATOM 5072 CE2PHEB 10 -52.432-27.492-110.558 1.0056.98 B

ATOM 5073 CZ PHEB 10 -51.165-27.322-111.0781.0056.71^" B

ATOM 5074 C PHEJB 10 -55.460-22.429-110.4571.0067.11 -B

ATOM 5075 O PHEB 10 -55.086-21.263-110.333 1.0067.71 B

ATOM 5076 N ALAB 11 -56.678-22^38-1-10.115 1.0068.67 B ATOM 5077 CA ALAB 11 -57.707-21.902-109:680 1.6070.27 B

ATOM 5078 CB ALAB 11 -58.896-22.652-109.1001.0068.57 B

ATOM 5079 C ALAB 11 -57.155-20.909-108.663 1.0071.71 B

ATOM 5080. O ALAB 11 -56.225-21.219-107.9181.0072.90 B

ATOM 5081 N ALAB 12 -57.733-19.712-108.638 1.0072.92 B ATOM 5082 CA ALA B 12 -57.859-18.947-107403 1.0074.07 B

ATOM 5083 CBALAB 12 -SO40 -17.469-107.7T0 H)O 72.91 B

ATOM 50S4 C ALAB 12 -59.011-I9;SΘΘ--1Θ6.57O 1T00T5.73 B

ATOM 5085 O ALA-B 12 -60.156-4-9,071-1.06.7161.0077.55. B

ATOM- 5086 TST ALAB 13 -Sg-JOl -2Qr453-105.6971.0076.25 B ATOM 5087 CA ALAB 13 -59:416-20=599-104.435 1.00--75.92 B

ATOM- 5088 CB ALA-B 13^' -60.09-7-21.956-104.349 1.0α75τ43 B

ATOM 5089 C ALAB 13 -58.36^20:453_^103.3371.0075,80 B

ATOM 5090 O- ALAB B -57.430-19.668-103.462 1.0075.94 B

ATOM 5091 N GLU-B L4 -58.537-21.216-102.261 1.0074,83 B ATOM 5092 CA GLUB 14 -57.429-21.541-101.372 1.0073.72 B

ATOM 5093 CB GLUB 14 -57.877-21.346-99.9221.0074.12 B

ATOM 5094 CG GLUB 14 -57.058-22.129-98.908 1.0073.92 B

ATOM 5095 CD GLUB 14 -57.272-21.644-97.488 1.0074.21 B

ATOM 5096 OEl GLU B 14 -57.842-20.546-97.312 1.0074.20 B ATOM 5097 OE2GLUB 14 -56.871-22.360-96.5471.0074.30 B

ATOM 5098 C GLUB 14 -56.850-22.940-101.558 1.0073.11 B

ATOM 5099 O GLUB 14 -55.634-23.130-101.530 1.0073.96 B

ATOM 5100 N ALAB 15 -57.731-23.917-101.749 1.0072.25 B ATOM 5101 CAALAB 15 -57.319 -25.246-102. L85 1.007-1.72 B

ATOM 5102 CB ALAB- 15 -58.323-26.291-101.7221.0071.15 B

ATOM 5103 C ALAB 15 -57.153-25.302-103.7001.0070.77 B

ATOM 5104 O ALAB 15 -56.965-26.398-104.2521.0070.75 B

ATOM 5105 N GLYB 16 -57.212-24.163-104.343 1.0069.58 B- ATOM 5106 CA GLYB 16 -56.501 -23.953-105.591 IJOO 68.31 B

ATOM 5107 C GLYB 16 -55.011-23.765-105.3841.0067770- B

ATOM 5108 O GLYB 16 -54.198 -24.288-106J471.006-7.48 B

ATOM 5109 N ALAB 17 -54.652-23.014-104.3481.0067.05 B

ATOM 5110 CA ALAB 17 -53.256-22.828-103.9861.0065.80 -B ATOM 5111 CB ALAB 17 -53.135-21.823-102:843 1.00-64.98- B

ATOM 5112 C ALAB 17 -52.723-24.186-103.5591.0065.24 B

ATOM 5113-0 ALAB 17 -51349 -24.504-103.7571.0065.62 B

ATOM 5114 N GLNB 18 -53.594-25.019-103.051 1.0064.06 B

ATOM 5115 CAGLNB 18 -53.152-26.309-102.623 1.0063.82 B ATOM 5116 CB GLNB 18 -54.247-27.059^-101.9501.0063.41 B

ATOM 5117 CG GLNB 18 -54.334 -26.76J-100.5551.00 €L99 B

ATOM 5113 CD GLNB 18 -53.178-27.285-99,803 1.0064.56 B

ATOM -5119 OEl-GLNB 1-8 -53.147-27.199 -98-.60-HJOO 64:89- B

ATOM 5120- NE2 GLN-BJ 8 -52:217 -277825-100.495 1.00=63.79 B ATOM.5121-C GLNB 18 -52.737 -27.095--103.785 LOO 63.64 B-

ATOM 5122 O GLNrB-IS- -51.6-91-27.685-103.7951700-64.23, B

ATOM 51-23 N ALA^'B^" 19- -53.613 -27.168- 1=04.763^" 1.0063vθ4 B

ATOM 5124 CA ALAB 19 -53.338-27.971-105.9521.0061.37 B

ATOM 5125 CB ALAB 19 -54.534-27.927-106.894 1.0061.30 B ATOM 5126 C ALAB 19 -52.103-27.368-106.615 1.0060.04 B

ATOM 5127 O ALAB 19 -51.296-28.065-107.242 1.0058.73 B

ATOM 5128 N PHEB 20 -51.971-26.054-106.4551.0058.60 B

ATOM 5129 CA PHEB 20 -50.840-25.314-106.991 1.0057.84 B

ATOM 5130 CB PHE B 20 -50.975 -23.832-106.6451.0057.99 B ATOM 5131 CGPHEB 20 -49.794-23.012-107.0601.0058.34 B

ATOM 5132 CDlPHEB 20 -49.730-22.454-108.3301.0059.68 B

ATOM 5133 CD2PHEB 20 -48.720-22.840-106.205 1.0058.61 B

ATOM 5134 CElPHEB 20 -48.610-21.738-108.743 1.0059.80 B ATOM 5135 CE2PHEB 20 -47.597-22.128-106.6091.0059.35 B

ATOM 5136 CZ PHEB ^"20 -47.543-21.577-107.881 1.0059.69 B

ATOM 5137 C PHEB 20 -49.549-25.862-106.3741.0057.25 B

ATOM 5138 O PHEB 20 -48.666-26.346-107.0921.0057.78 B

ATOM 5139 N ALAB 21 -49.450 -25.777-105.045 1.0055.66 B ATOM 5140 CA ALAB 21 -48.284-26.253-104.301 1.0054.60 B

ATOM 5141 CB ALAB 21 -48.451-25.943-102.8281.0055.O5 B

ATOM 5142 C ALAB 21 -48.065-27.748-104.493 1.0054.24 B

ATOM 5143 O ALAB 21 -46.935-28.239-104.4041.0054.07 B

ATOM 3144 N ALAB 22 -49.185-28.473-104.7021.0053.94 B ATOM 5145 CA ALAB 22 -49.107-29.905-104.968 1.00.53.41 B

ATOM 5146 CB ALAB 22 -50.501-30.487-105.148 1.0053.91 B

ATOM 5147 C ALAB 22 -48.248-30.192-106.1941.0052.65 B

ATOM 5148 O ALAB 22 -47.327-30.966-106.1701.0051.91 B

ATOM 5149 N ALAB 23 -48.549-29.407-107.268 1.0051.94 B ATOM 5150 CA ALA B 23 -47.814-29.485-108.5441.0051.68 B

ATOM 5151 CB ALAΗ 23 -48.618-28.774-109.6781.0051.03 B

ATOM 5a 52 C ALAB 23 -46.401 -28.874-10&4461.0051.12 B

ATOM 5153 O ALA-B 23 -45.414 -2S.-521-108.8181.00-50.79- B

ATOM 51-54 N TYR B JA- -46.304 -27.639-107.9541.0049?86 B^" ATOM 5155_CA TYRB 24 -45.007-26.9824=07.81-3 1.0049.14 B

ATOM 5156 -CB TYRB 24 -45.090 -25.832-106^11 1.0049.68 B

ATOM 5157 CG TYRB 24 -43.726 -25TZ8&- 10614251.0050.26 B

ATOM 5158 CDlTYRB 24 -43.164-24.207-107.1001.0050.10 B-

ATOM 5159 CEl TYR B- 24 -41.875-23.761-106.7971.0049.95 B ATOM 5160 CD2 TYRB 24 -42.963-25.907-105.4271.0050.66 B

ATOM 5161 CE2TYRB 24 -41.676-25.470-105.121 1.0049.95 B

ATOM 5162 CZ TYRB 24 -41.138-24.399-105.8091.0049.59 B

ATOM 5163 OHTYRB 24 -39.864-23.974-105.5141.0048.79 B

ATOM 5164 C TYRB 24 -43.933-27.950-107.3321.0048.54 B ATOM 5165 O TYRB 24 -42.851-28.048-107.905 1.0047.92 B

ATOM 5166 N ASNB 25 -44.291-28.723-106.331 1.0047.79 B

ATOM 5167 CA ASNB 25 -43399-29.676-105.7071.0048.42 B

ATOM 5168 CB ASNB 25 -44.137-30.483-104.674 1.0048.76 B ATOM 5169 -CG ASNB 25 -43.354-31.700-104.180 1.0050.17 B

ATOM 5170 ODl ASNB 25 -42.261 -31.583-103.60:8 1.0050.11 B

ATOM 5171 ND2 ASNB 25 -43.881-32.861-104.433 1.0050.41 B

ATOM 5172 C ASNB 25 -42.840-30.646-106.6441.0049.22 B

ATOM 5173 O ASNB 25 -41.685^" -30.978-106.5381.0048.88 B ATOM 5174 N SERB 26 -43.708 -31.174-107.4821.0049.87 B

ATOM 5175 CA SERB 26 -43.369-32.229-108.4421.0049.71 B

ATOM 5176 CB SERB 26 -44.643-32.799-109.052 1.0050.34 B

ATOM 5177 OG SERB 26 -44.320-33.802-109.9971.0053.39 B

ATOM 5178 C JSERB 26 -42.462-31.732-109.5561.0049.13 B ATOM 5179 O SERB 26 -41.587-32.458-110.039 LOO 48.44 B

ATOM 5180 N SERB 27 -42.698 -30.493-L09.972 1.0047.88 B

ATOM 51*1 CA SERB 27 -41.901 -29.873-11L0171.0048.23 B

ATOM 51-82 CB SERB 27 -42.605-28.608-111.523 1.0048.36 B

ATOM 5183 OG-SERB 27 -43.97£-28:846-l 11.788 1.0046.35 B ATOM 5184 C SERB 27 -40.551-29.507-110.3971.0048.69 B

ATOM- 51850 SERB 27 -39.493 -29.762-1 V0.975 1.0049.04 B

ATOM 51*6 N ALA B^" 28. -4Θ.613-28.921-109.202 1.0048.59 B

ATOM 5187 CA ALAB 28 -39.447-28_^496-1-0^.43« 1.0047.29 B

ATOM 5188--CR-ALA-&28 -39.895-27.934-107.098 IM 47.03 B ATOM 5189 C JVLA-B 28 -38.412 -29.603-4=08.221 1.004.6.49 B

ATQM 5190- O ALA-B 28 -371224 -29τ398-108.44G 1.0045.72 B

ATOM 5191 N GLUB 29 -38.801-30.740-107.8121.0046.46 β-

ATOM 5192 CA GLUB 29 -37.893-3-1.804-107.5771.0046.37 B

ATOM 5193 CB GLUB 29 -38.701-33.009-107,153 1.0047.98 B- ATOM 5194 CG GLUB 29 -38.290-33.785-105.911 1.0050.51 -B

ATOM 5195 CD GLUB 29 -39.075-35.049-105.7591.0052.32 B

ATOM 5196 OElGLUB 29 -40.250-34.983-105.472 1.0053.33 B

ATOM 5197 OE2 GLUB 29 -38.527-36.109-105.9371.0053.21 B

ATOM 5198 C GLUB 29 -37.083-32.114-108.7771.0045.28 B _o,_o

239

ATOM 5199 O GLUB 29 -36.033-32.579-108.645 1.0044.73 B

ATOM 5200 N GLNB 30 -37.600-31.920-109.953 1.0044.58 B

ATOM 5201 CA GLNB 30 -36.865-32.169-111.183 1.0044.92 B

ATOM 5202 CB GLNB 30 -37.841-32.240-112.3681.0046.05 B ATOM 5203 CG GLNB 30 -38.964-33-266-112.208 1.0048.19 B

ATOM- 5204 CD GLNB 30 -39.831-33.390-113.453 1.0049.32 B

ATOM 5205 OElGLNB 30 -39.345-33.763-114.5191.0050.12 B

ATOM 5206 NE2 GLN B 30 -41.120-33.078-113.323 1.0048.99 B

ATOM 5207 C GLNB 30 -35.812 -31.098-111.4441.0044.65 B ATOM 5208 O GLNB 30 -34.626-31.394-111.621 1.0043.93 B

ATOM 5209 N VALB 31 -36.258 -29.849-111.4671.0044.19 B

ATOM 521Θ CA VALB 31 -35.374-28.722-111.713 1.0043.44 B

ATOM 5211 CB VALB 31 -36.204-27.417-111.863 1.0041.66 B

ATOM 5212 CGl VALB 31 -36.954 -27.13.1-110.593 1.0042.68 B ATOM 5213 CG2VALB-31 -35:304-26.260-112.2341.0043.06 B

ATOM 5214 C VALB 31 -34.317-28.594-110.603 1.0044.24 B

ATOM 5215 O VALB 31 -33.183-28.164-110.8521.0045.27 B

ATOM 52J6 N LEUB 32 -34.679-28.988-109.3S5 1.0044.27 B

ATOM 5217 CA LEUB 32 -33.749-28.934-108.263 1.0043.44 B ATOM „5218 CB LEUB 32 -34.513-29.006-106.9391.0043.05 B

ATOM 5219 CG LEUB 32 -35.272-27.718-106.5971.0042.75 B

ATOM 5220 CDlLEUB 32 -36.415 -28.039- L05.666 LOO 43.93 B

ATOM 5221 CD2LEUB 32 -34.330-26.684-105.983 1.-Θ041.86 B

ATΘM ^222 C EEUB-32 -32.722 -30.0_63_d08:363- 1.0043.54 B ATOM 5223 O LEUB 32 -31:522-29.824-108.228 1.0044.21 J3_

ATOM 5224-N EHEB 33 -33.1-81 -31.290- 108.5981.ΘΘ4Z66 B

ATOM 3225 CA PHEB- 33 -32.254-32.402-108.7421.0041.35 B

ATOM 5226 CB PHEB 33 -32.984-33.679-109.150 1.0038.10 B-

ATOM 5227 CG PHE B 33 -32.065 -34.852-109.365 1.0036.01 B ATOM 5228 CDl PHE B 33 -31.623-35.617-108.2951.0034.93 B

ATOM 5229 CD2 PHE B 33 -31.604-35.168-110.633 1.0034.86 B

ATOM 5230 CEl PHE B 33 -30.734 -36.678-108.4861.0033.37 B

ATOM 5231 CE2PHEB 33 -30.716-36.226-110.8301.0033.59 B

ATOM 5232 CZ PHEB 33 -30.283-36.980-109.753 1.0032.83 B ATOM 5233 C PHEB 33 -31.285-32.016-109.8561.0042.35 B

ATOM 5234 O PHEB 33 -30.077-32.256-109.772 1.0041.76 B

ATOM 5235 N ALAB 34 -31.835-31.409-110.9021.0042.78 B

ATOM 5236 CA ALAB 34 -31.040.-30.987-112.045 1.0043.77 B ATOM 5237 CB ALAB 34 -31.923 -30.267-113.058 1-.0042.82 B

ATOM- 5238 C ALA B 34 -29.899-30.077-111.623 1.0044.38 B

ATOM 5239 O ALAB 34 -28.732-30.334-111.938 1.0044.30 B

ATOM 5240 N SERB 35 -30.248-29.013-110.9061.0044.38 B

ATOM 5241 CA SERB 35 -29.271-28.034-110.4561.0044.59 B ATOM- 5242 CB SERB 35 -30.000-26.825-109.858 1.0045.78 B

ATOM 5243- OG- SER B 35- -29.184-25.663-109,880 1.0047.82 B

ATOM 5244 C SERB 35 -28.250-28.591-109.458 1.0043.59 B

ATOM 5245 O SERB 35 -27.059-28.287-109.562 1.0044.28 B

ATOM 5246 N VAL B 36 -28.707 -29.404-108.505 1.0041.95 B ATOM 5247 CA VAX B 36- -27.821 -29.990-1G7.4941.004039 B

ATOM 5248 CB VALB 36 -28.609 -30.762-L06.428 1.0039.58 B

ATOM 5249 CGl VAL B 36 -27.642-31.451-105.468 1.0036.88 B

ATOM 5250 CG2VALB 36 -29.527-29.814-105.6791.0038.79 B

ATOM 5251 C VALB 36 -26.811-30.949-108.0891.0040.71 B ATOM 52520 VALB 36 -25.675-31.027-107.633 1.0039.96 B

ATOM 3253 N ALAB 37 -27.246-31.693-109.098 1.0041.39 ^"B

ATΘM 5254 CA-ALAB 37 -26.385-32.656-109.775 1.00-40.62 B

ATOM 5255 CB ALA-B 37 -27.227 -33.5ai-M0.642 1.0039.52 B

-ATOM 5256 C ALAB 37 -.25.3-8.O. -31.889-110.628 ^"LO.0-40.74 B ^"ATOM 5-257 O- ALA B 37 -24.226-32.297-110.7801.0039:89 B

ATOM 5258 N ALA-B 38 -25τ8-35 -30.767-111.1761.0041.60 B

AIQM 5259 CA-ALAB 38" -24:995-29.918-112:609 LΘΘ42τ68 -B

ATOM 5260 CB ALA-B 38 -25.827-28.794-112.621 1,0042.51 B

ATOM 5261 C ALAB 38 -23.884-29.345-111.1461.0042.95 B ATOM 5262 O ALAB 38 -22.756-29.160-111.6021.0044.56 B

ATOM 5263 N SERB 39 -24.214-29.065-109.8921.0042.49 B

ATOM 5264 CA SERB 39 -23.240-28.529-108.9581.0042.08 B

ATOM 5265 CB SERB 39 -23.951-27.859-107.7861.0042.41 B

ATOM 5266 OG SERB 39 -24.828-26.847-108.248 1.0044.05 B ₀ , .

241

ATOM 5267 C SERB 39 -22.333-29.646-108.4541.0041.88 B

ATOM 5268 O SERB 39 -21.125-29.462-108.3571.0041.65 B

ATOM 5269 N TRPB 40 -22.908-30.807-108.1371.0042.21 B

ATOM 5270 CA TRPB 40 -22.104-31.927=107.6591.0041.85 B ATOM 5271 CB-TRP-B 40 -22.960-33.176-107.4091.0042.00 B

ATOM 5272 CG TRPB 40 -22.120-34.359-1.07.0071.0042.09 B

ATOM 5273 CD2TRPB 40 -21.790-34.766-105.6721.0042.28 B

ATOM 5274 CE2TRPB 40 -20.867-35.829-105.7721.0042.93 B

ATOM 5275 CE3 TRPB-40 -22.180-34.332-104.3991.0041.18^" B ATOM 5276 CDlTRPB 40 -21.411 -J5.176-107.835 1.0042.40 B

ATOM -5277 NElTRPB 40 -20.653-36.659-T07.1041.0042.64 B

ATOM 5278 CZ2TRPB 40 -20.324-36.462-104.651 1.0043.20 B^"

ATOM 5279 CZ3 TRP B 40 -21.640-34.964-103.2841.0041.22 B

ATOM 5280 CK2 TRP-B 40. -20.723-36.017-103.4201.0041.92 B ATOM 5281 C TRPB 40 -21.002-32.271-108:6471.0042.30 B

ATOM 5282 O TRPB 40 -19.906-32.626-108.2421.0040.84 B

ATOM 5283 N ALAB 41 -21.297-32.173-109.9391.0044.15 B

ATOM 5284 CA ALA B 41 -20.311-32.471-110.976-1.0045.82 B

ATOM 5285 CB ALAB 41 -20.956-32.384-112.3421.0047.01 B ATOM 5286 C ALAB 41 -19.127-31.517-110.9061.0047.23: B

ATOM 5287 O ALAB- 41 -17.982 -31.939-11170341.0047.49 B

ATOM 5288 N HfSB 42 -1-9.415-30:232-110:7041.004-9.24 B

ATOM- 52-89 CA HϊS-B-42 -.18.384 -29.189-1 L0:605 1.0050.67 B

ATOM 5290 OEUHIS ΕT42- -19.047-27.801-110.5361.00^2.13 B - ATOM 5291 CG HISB -42 -1S.075" -26.660^"- 110.452 J.0O 54.64 B

ATOM 5292^" CD2 HS B 42 -17.029 -26.316- HL243 1.0055τ35 B^"

ATOM 5293 NDl-HIS-B 42 .18.141 -25.697-109.4661.0056.25 B

ATOM .5294 CElHISB 42 τl7.T79 -24.810-lθ9τ651 1.0055.97 B

ATOM 5295 NE2 HIS B 42 -16.491-25.162=110.723 1.0056.01 B ATOM 5296 C HIS B 42 -17.466 -29.370-109.3891.0050.68 B

ATOM 5297 O HISB 42 -16.261-29.574-109.5381.0050.30 B

ATOM 5298 N ASPB 43 -18.048-29.297-108.196 1.0050.66 B

ATOM 5299 CA ASP B 43 -17.270-29.280-106.963 1.0050.96 B

ATOM 5300 CB ASPB 43 -18.188-29.097-105.753 1.0050.64 B ATOM 5301 CG ASPB 43 -18.951-27.788-105.793 1.0051.47 B

ATOM 5302 ODl ASP B 43 -19.919-27.637-105.018 1.0050.88 B

ATOM 5303 OD2ASPB 43 -18.656-26.852-106.5661.0051.69 B

ATOM 5304 C ASPB 43 -16.445-30.554-106.^09 LOO 51.63 B ATOM 5305 O ASPB 43 -15338 -30.525-106:272 IJOO 51.56 B

ATOM 5306 N THRB 44 -Iότ992 -31.6-70-107.2801.0053=02 B

ATOM 5307 CA THRB 44 -16.305-32.953-107.1971.0054.36 B

ATOM 5308 CB THRB 44 -17.308-34.113-107.3351.0054.74 B

ATOM 5309 OGlTHRB 44 -18.272 -34.043-106.27-8 l.OΘ 57.07 B ATOM 5310 CG2THRB 44 -16.617-35.447-107.091 1.005^.01 B

ATOM 5311 C THRB 44 -15.221-33.069-108.263 1.00-54.48 B

ATOM 5312 O THRB 44 -14387 -33.974-108.2181.0054.85 B

ATOM 5313 N ASNB 45 -15.238-32.148-109.2201.0054.87 B

ATOM 5314 CA ASNB 45 -14.275 -32.162-1-10.315 L00-54.77 B ATOM 5315 CB ASNB 45 -14.558 -33.331-111.2621.0055785 B

ATOM 5316 CG ASNB 45 -13.603-33.371-112.4381.0057.81 B

ATOM 5317 ODlASNB 45 -12.418-33.068-112.3021.0058.60 B

ATOM 5318 ND2 ASN B 45 -14.116-33.748-113.6041.0058.79 B

ATOM 5319 C ASNB 45 -14.268-30.850-111.092 1.0054.31 B ATOM 5320 O ASNB 45 -14.972-30.704-112.091 1.0055.11 B ATOM 5321 N ILEB 46- -13.467-29.89-7-110,625 1.00,53.32 B-

ATOM- 5322 CA ILE-B 46 -13.453-28.558-111.202 bOO-52.23 B

ATOM 5323.CB ILE B- 46 -12.720-27.576-110.2681.0032.28 B

ATOM 5324 CG2-ELEB 46 -12.999-26.139-110:632- 1.0053.29 B ATOM^" 53-25 CGl ELE-B 46 -13.137-27.811-103:8151.0052.05 B

ATOM- 5326^' CDl ILE-B 46 -12.513 -26.840- IW. S371.0051.23 B AT-OMT 5327 C ILE B 46 -12.798 -28.553-11-2.58O l.QO_5JL88 B ATOM 5328 O ILEB 46 -11.579 -28.683-112.6981.0051.48^~ B

ATOM 5329 N THRB 47 -13.616 -28.418-113.6181.0051.27 B ATOM 5330 CA THRB 47 -13.121-28.051-114.9391.0049.36 B

ATOM 5331 CB THRB 47 -13.576-29.082-115.9901.0048.57 B

ATOM 5332 OGlTHRB 47 -15.002-29.218-115.9441.0046.98 B

ATOM 5333 CG2THRB 47 -13.080-30.472-115.623 1.0047.03 B

ATOM 5334 C THRB 47 -13.589-26.656-115.3351.0049.58 B ATOM 5335 O THRB 47 -13.743-25.778-114.4861.0050.94 B

ATOM 5336 N ALAB 48 -13.815-26.457-116.6301.0048.24 B

ATOM 5337 CA ALAB 48 -14.425-25.231-117.1181.0046.89 B

ATOM 5338 CB ALAB 48 -13.529-24.570-118.1141.0045.80 B ATOM 5339 C ALAB 48 -15.725 -25.637-117.774 LOO 47.35 B

ATOM 5340 O ALAB 48 -16.640-24.837-117.9441.00^"46;78 B

ATOM 5341 N GLUB 49 -15.876-26.895-118.0041.0048.84 B

ATOM 5342 CA GLUB 49 -17.075-27.337-118.623 1.0048.83 B

ATOM 5343 CB GLUB 49 -16.838-28.598-119.351 1.0050.26 B ATOM 5344 CG GLU B 49 -18.145-29.149-119.7891.0053.34 B

ATOM 5345 CD GLUB 49 -18.281-29.144-121.254' 1.0054.70 B

ATOM 5346 OElGLUB 49 -17.881-30.131-121.8371.0056.93 B

ATOM 5347 OE2 GLU B 49 -18.771-28.164-121.8141.0054.66 B

ATOM 5345 C GLUB 49 -18.100-27.630-117.6561.0046.95 B ATOM 5349 O GLUB 49 -19^".221 -27.304-117.8-23 1.0045.53 B

ATOM 5350 N ASNB 50 -17.718-28.327-116.6291.0044.90 B

ATOM 5351 GA ASNB 50 -18.694 -28.57&-115.5901.0042.44 B

ATOM 5352 CB ASNB 50 -18.067-29.424-114.4881.0040.63 B

ATOM 5353 CGASNB 50 -17.760-30.827-114.9521.0039.27 B ATOM 5354 ODlASNB 50 -18.610-31.481-115.545 1.0040.19 B

ATOM 3355 ND2ASNB 50 -16.550 -31.300-114.6S3 1.0036.86 B

ATOM 5356 C ASN=B 50 -19.169 -27.249-115.945 1.0042.45 B

ATOM- 5357 O ASN B_50 -20.295 -27.-136-114,5651.0D42τ37 B.

ATOM- 5358- N- ALAB^" 51 -18.29.8_-26.244-l-15.14^"41.0042.60 B - ATΘM 5359 CAi-ALA B-51 —18.597 -24.891-114τ672 LOO 42.52 B

ATOM 5360 CB ALAB 51 -17.327-24.058-114,643 1.0041.75 B

ATOM 5361 C ALA-B- 51 -1976T6 -24.223-115,5651:00-42.31 B.

ATOM 5362 O ALAB 51^" -20.491-23.471-115.089- Ϊ.0Q 41.82 B

ATOM 5363 N ALAB 52 -19.549-24.499-116.8641.0041.98 B ATOM 5364 CA ALA B 52 -20.481 -23-.945-117.8321.0041.01 B

ATOM 5365 CB ALAB 52 -19.937-24.108-119.233 1.0040.47 B

ATOM 5366 C ALAB 52 -21.791-24.691-117.6821.0041.28 B

ATOM 5367 O ALAB 52 -22.859-24.125-117.8821.0041.39 B

ATOM 5368 N ALAB 53 -21.700-25.980-117.3281.0042.57 B ATOM 5369 CA ALAB 53 -22.867-26.828-117.1171.0043.00 B

ATOM 5370 CB ALAB 53 -22.454-28.290-117.0471.0041.61 B

ATOM 5371 C ALAB 53 -23.619-26.425-115.853 1.0043.73 B

ATOM 5372 O ALAB 53 -24.847-26.383-115.8101.0043.23 B ATOM 5373 N. GLNB 54 -22.957-26.216-114.7501.0044.28 B

ATOM 5374 CA GLNB 54 -23.683^" -25.627-113.678 1.0044.98 B

ATOM 5375 CB GLNB 54 -22.850-25.405-112.459 1.0047.10 B

ATOM 5376 CG GLNB 54 -23.633-24.635-111.4201.0051.27 B

ATOM 5377 CD GLNB 54 -22.892 -23.476-110.9291.0053.99 B ATOM 5378 OElGLNB 54 -21.720 -23.390-111.181 1.0056.99 B

ATOM 5379 NE2 GLN B 54 -23.561-22.544-110.2891.0053.73 B

ATOM 53&0 C GLNB 54 -24.254-24.340-114.041 1.0043.60 B

ATOM 5381 O GLNB 54 -25.396-24.099-113.825 1.0043.14 B

ATOM 5382 N GLUB 55 -23.424-23.457-114.530 1.0041.89 B ATOM 5383 CA GLUB 55 -23.952 -22.14Θ-114.873 1.Θ041.00 B

ATOM 5384 CB GLUB 55 -22.883-21.304-115.5861.0041.89 B

ATOM 5385 CG GLUB 55 -21.760-20,845-114.6721.0045.11 B

ATOM 5386 CD GLUB 55 -20.838-19.824-115.319 1,0046.58 B

ATOM 5387 OElGLUB 55 -21.353 -1&.802-115.831 1.0048.54 B ATOM 5388 OE2GLUB 55 -19.602-20.037-115.305 1.0046.69 B

ATOM 5389 C GLUB 55 -25.215-22.207-115.7261.0039.95 B

ATOM 5390 O GLUB 55 -26.Q02 -21.25.7-115.7541.0039,02 B

ATOM 5391 N ALAB 56 -25.389^" -23JL4-116.4.6S 1.00-38.40 B-

JcFΘM 5392 CA ALAB 56 -26.60.4-23.483-117.2491,0036.55_ B ATOM 5393 CB ALAB_56 -26.387-24.51.7-118.343 1:00-36.66- B

ATOM 5394 -C ALAB 56- -27.783 -23.880-116.3671.0035τ55 B

ATOM 5395 O ALAB 56 -28:797-23.236-116.347 LOJO 35D2 B

ATOM 5396 N ALAB 57 -27.518-24.924-115.550 1.0035.05 B

ATOM 5397 CA ALAB 57 -28.517-25.431-114,611 1.0034-53 B ATOM 5398 CB ALAB 57 -27.924-26.545-113.766 1.0034J4 B

ATOM 5399 C ALAB 57 -29.000-24.306-113.722 1.0033.93 B

ATOM 5400 O ALAB 57 -30.163-24.269-113.3301.0033.13 B

ATOM 5401 N ALAB 58 -28.090-23.390-113.413 1.0033.78 B

ATOM 5402 CA ALAB 58 -28.398-22.234-112.583 1.0034.55 B ATOM 5403 CB ALAB 58 -27.121-21.478-112.2741.0034.34 B

ATOM 5404 C ALAB 58 -29.399-21.315-113.2841.0035.08 B

ATOM 5405 O ALAB 58 -30.341-20.820-112.6671.0034.71 B

ATOM 5406 N LEUB 59 -29.177-21.080-114.5741.0035.83 B ATOM 5407 CA LEUB .59 -30.068-20.239-115.3601.0036.67 B

ATOM 5408 CB LEUB 59 -29.495-20.007-116.7571.0036.51 B

ATOM 5409 CG LEUB 59 -28.641-18.751-116.931 1.0036.85 B

ATOM 5410 CDlLEUB 59 -28.183-18.618-118.3701.0035.53 B

ATOM 5411 CD2LEUB 59 -29.459-17.543-116.5271.0037.97 B ATOM 5412 C LEUB 59 -31.406-20.935-115.4741.0036.99 B

ATOM 5413 O LEUB 59 -32.456-20.298-115.5171.0037.58 B

ATOM 5414 N LEUB 60 -31.346-22.259-115.5241.0037.01 B

ATOM 5415 CA LEUB 60 -32.534-23.096-115.6241.0036.41 B

ATOM 5416 CB LEUB 60- -32.109-24.562-115.7201.00.36.62 B ATOM 5417 CG LEUB 60 -32.923-25.499-116.6161.0037.02 B

ATOM- 5418 CDlLEUB 60 -32.148-26.801-116.830 1.0036.13 B

ATOM 5419 CD2LEUB 60 -34.280-25.761-115.9921.0037.37 B

ATOM 5420 C LEUB 60 -33.411-22.878-114.3891.0035.97 B

ATOM 5421 O LEUB 60 -34.581-22.500-114.4971.0034.67 B ATOM 5422 N SERB 61 -32.827-23.112-1132151.0035.05 B

ATOM 5423 CA SERB 61 -33.526-22.943-111.951 1.0033.47 B

ATOM 5424 CBSERB 61- -32.569 -23.207- ITQ..7901.0033.42 B

ATOM 5425 OG SERB 61 -31.968-24.485-110.8851.0032.02 B

ATOM 542« C SERB 61 -34:084--21.533-l 11.8371.0033:67 B ATOM 5427 O SERB 61 -35,223

B

AΕΘM 5428 T? GLNB-OZ -33.274 -20.555-112210^' 1.0034.66 B

ATOM 5429 CA GLN B-62 -33.687-19.162-112.1361.0037.21 B

ATOM 5430 CB GLNB 62 -32.557-18.258-112.6071.0036.85 B

ATOM 5431 -CG GLNB 62 -31.340-18.318-111.7321.003638- B ATOM 5432 CD GLNB 62 -30.381-17.200-112.0301.0037.93 B

ATOM 5433 OElGLNB 62 -29.512-17.318-112.8881.0037.21 B

ATOM 5434 NE2 GLN B 62 -30.548-16.093-111.3281.0040.42 B

ATOM 5435 C GLNB 62 -34.939-18.899-112.9521.0039.48 B

ATOM 54360 GLNB 62 -35.773-18.075-112.5831.0039.62 B ATOM 5437 N GLUB 63 -35.060-19.597-114.073 1.0042.76 B

ATOM 5438 CA GLUB 63 -36.236-19.458-114.9291.0045.86 B

ATOM 5439 CB GLUB 63 -36.043-20.230-116.231 1.0047.89 B

ATOM 5440 CG GLUB 63 -35.319-19.468-117.3141.0052.67 B ATOM 5441 CD GLUB 63 -35.119-20.314-118.5471.0055.44 B

ATOM 5442 OElGLUB 63 -34.156-21.116-118.561 1.0056.48 B

ATOM 5443 OE2 GLU B 63 -35.931-20.183-119.4941.0057.55 B

ATOM 5444 C GLUB 63 -37.439-20.030-114.1921.0045.69 B

ATOM 5445 O GLUB 63 -38.459-19.359-114.018 1.0045.83 B ATOM 5446 N PHEB 64 -37-293-21.283-113.7681.0045.52 B

ATOM 5447 CAPHEB 64 -38,320-22.008-113.0391.0044.84 B

ATOM 5448 CB PHEB 64 -37.698-23.230412.378 1.0043.76 B

ATOM 5449 CG PHE B 64 -38.689-24.114-111.699 1.0044.45 B

ATOM 5450 CDlPHEB 64 -39.525 -24.938-112.440 LOO 45.22 B ATOM 5451 CD2PHEB 64 -38.784-24.135410.314 LOO 45.07 B

ATOM 5452 CEl PHE B 64 -40.442-25.778-111.813 1.0046.26 B

ATOM 5453 CE2 PHE B 64 -39.699 -24.968-109.674 LOO 45.80 B

ATOM 5454 CZ PHEB 64 -40.530-25.792-110,4261.0046.14 B

ATOM 5455 C PHEB 64 -38.961-21.139-111.9691.O045.88 B ATOM 5456 O PHEB 64 -40,144 -20.803-112.J04O 1.0046.68 B

ATOM 5457 N AULB 65 -38.157-20.778-110.976 1.0046.35 B

ATOM 5458- CA. ALA B 65 -38.622-19.964-109.868 1:0047.08 B

ATOM 5459 CB ALAB 65 -37.451-19.611-108.973 1.0046.91 B-

ATOM 5460 C ALAB 65 -39:344 -L8,700-l 10.31-51:00-47.83- B ATOM 546J O ALAB 65 -40.204-18.191-109.604 LQO 4837 B

ATOM.5462^" N GLU B-66 -39.103-18:235-111.5071.0049.09 B-

ATOM 5463 CA-GLUB 66 -39.786-17.050-111.93-2 LflO 50.96 B

ATOM- 5464 CB GLUB 66 -39.024-16.326-112.9641.0052.58 B

ATOM 5465 CG GLUB 66 -39.513-14.922-113.0441.0056.18 B ATOM 5466 CD GLUB 66 -39.814-14.476-114.4171.0058.98 B

ATOM 5467 OElGLUB 66 -38.978-14.703-115.283 1.0060.94 B

ATOM 5468 OE2 GLU B 66 -40.875-13.889-114.6051.0060.27 B

ATOM 5469 C GLUB 66 -41.087-17.308-112.4991.0051.26 B

ATOM 5470 O GLUB 66 -41.987-16.558-112.315 1.0051.03 B _9Δ7

247

ATOM 5471 N ALAB 67 -41.178-18.365-113.2541.0052.07 B

ATOM 5472 CA ALAB 67 -42.476-18.728-113.811 1.0052.84 B

ATOM 5473 CB ALAB 67 -42.365-20.012-114.621 1.0052.70 B

ATOM 5474 C ALAB 67 -43.432-18.930-112,6471.0053.22 B ATOM- 5475- O ALAB 67 -44.400-18.182-112.4761.0052.93 B

ATOM 5476 N TRPB 68 -43.139-19.948-111.8451.0053.86 B

ATOM 5477 CA TRPB 68 -43.946-20.270-110.6791.0054.39 B

ATOM 5478 CB TRPB 68 -43.308-21.408-109.905 1.0053.62 B

ATOM: 5479 CG TRFT368 -43.258-22.646-110.700 1.0Θ 53.60 B ATOM 5480 CD2 TRP F 68 -44.245-23.681-110.7201.0054:03 B

ATΘM 5481 CE2 TRP B 68- -43.830 -24.634-111.675 LOO 54.11 B

ATOM 5482 CE3 TRP B 68 -45.446-23.893-110.023 1.0053.39 B

ATOM 5483 CDlTRPB 68 -42.310-22.996-111.6101.0053.21 B

ATOM 5484 NElTRPB 68 -42.646 -24. L89-112.203 1.0053.29 B ATOM 5485 CZ2 TRPB- 68 -44.575-25.791-111.955 1.0053.76- B

ATOM 5486 CZ3 TRP B -68 -46.185-25.041-110-2981.0053.38- B

ATOM 5487 CH2 TRP B 68 -45.745-25.976-111.2581.0054.05 B

ATOM 5488 C TRPB 68 -44.100-19.072-109.7701.0054.62 B

ATOM 5489 O TRPB 68 -45.218 -18.674-109.4491.0055.22 B ATOM 5490 N GLYB 69 -42.969-18.506-109.3591.0054.53 B

-ATOM 5491 CA GLYB- 69 -42.98-7 -17.350-108.484 1.0054.46 B

ATOM 5492 C GLY B^" 69 -43.985 -16.302.-108.9321.0054.90. B

ATOM' 5493 Q GLYB 69 -44:798-15.820-108.140 1.00-54.98 B

AEOM -5494 N ALAB 70 -43.918 -1-5342.- LL0.212 -1.0055.33 B ATO&T 5495^" CA ALAB -70^" -44.846 -14.949-110.7371.0055.94 B

ATOM- 5496 CB ALAB 78 -44.465-14.565-112.159 Lβθ 5448 B

ATOM^" 5497 C ALAB 70 -46.283 -15.456^1iO:6891.0056.35 B

ATOM 5498 O ALAB 70 -47Λ95 -14.723-110.4021.0056.93 B

ATOM 5499 N LYSB 71 -46.455-16.741-110.9801.0056.48 B- ATOM 5500 CA LYS B 71 -47.760-17.384-110.871 1.0057.25 B

ATOM 5501 CB LYSB 71 -47.676-18.845-111.3141.0057.24 B

ATOM 5502 CG LYS B 71 -49.026-19.494-111.5741.0058.19 B

ATOM 5503 CD LYS B 71 -49.706-18.887-112.7901.0059.03 B

ATOM 5504 CELYSB 71 -50.937-19.684-113.1891.0060.21 B _24g

ATOM 5505 NZ LYS B 71 -51.728-18.991-114.243 1.0061.81 B

ATOM 5506 C LYSB 71 -48.299-17.298-109.4471.0058.14 B

ATOM 5507 O LYSB 71 -49.313-16.646-109.194 1.0058.38 B

ATOM 5508 N ALAB 72 -47.615-17.96-1-108.520 1.0058.44 B ATOM 5509 CA ALA B 72 -47.947-17,8-59-107.1031.0058.43 B

ATOM 5510 CB- ALA B 72 -46.757-18.269-106.2501-00-58.00 B

ATOM 5511 C ALAB 72 -48.401-16.448-106.744 1.0059.21 B

ATOM 5512 O ALAB 72 -49.500-16.254-106.220 1.0059.26 B

ATOM 5513 N LYSB 73 -47.552 -15.468- 1O7:O291.0060.84 B ATOM 55 L4 CA LYSB 73 -47.935 -14.065^~-106.9201.0063.02 B

ATOM 5515 CB bYSB 73 -46.831-13.163-107.475 LOO^'63.27 B

ATOM 5516 CG LYSB- 73 -45.547-13.183-106.662 1.00-64:91 B

ATOM 5517 CD LYSB 73 -45.072-11.773-106.3471.0065.70 B

ATOM 5518 CE LYSB 73 -43.562-11.657-106.4741.0065.97 B ATOM 5519 NZ LYSB 73- -43.125-11.648-107:89-8 -1.00-66.77 B

ATOM 5520 C LYS B 73 -49.248 -13.794-107.645 1.0063.67 B

ATOM 5521 O LYSB 73 -50.252-13.444-107.0241.0064.03 B

ATOM 5522 N ALAB 74 -49.233-13.959-108.963 1.0064-36 B

ATOM 5523 CA ALA B 74 -50.398 -13.659-109.7861.0065.23 B ATOM 5524 CB ALAB 74 -50.208-14.202-111.1941.0065-04 B

ATOM 5525 C ALAB 74- -5 L672 -14220-109.164 1.0066.04 B

ATOM 5526 O ALAB 74 -52.680 -13-522-109-.O521.00-66.53 B

ATOM 5527 N LEU-B 75 -51,620-15.486-108.763 1.00-66.61 B

ATOM 5528 CA LEU B 75 -527812-16.199-108.3201.0067.26 B ATOM 5529 CB LEUB 75 -52:58-1 -17.7-10-108.3641.00..66.75 B

ATOM .5530 CG-LEU375 =53.155-18.449-109.574 kθfc66.11 B

ATOM 5531- CDlLEUB 75 -52.414 -_L8JO57-110.8441.0066.73 B

ATOM 5532 CD2 LEU B 75 -53.102-19.954-109.362 1.00-65.62 B

ATOM 5533 C LEUB 75 -53.222 -15.771-106.914 LQO 68.72 B ATOM 5534 O LEUB 75 -54.392-15.487-106.658 1.0068.73 B

ATOM 5535 N TYRB 76 -52.255-15.732-106.003 1.0070.14 B

ATOM 5536 CA TYRE 76 -52.531-15.372-104.6171.0071.22 B

ATOM 5537 CB TYRB 76 -52.842-16.619-103.786 1.0069.54 B

ATOM 5538 CGTYRB 76 -53.005-17.880-104.604 1.0068.51 B ATOM 5539 CDlTYRB 76 -51.897-18.598-105.033 1.0067.40 B

ATOM 5540 CElTYRB 76 -52.041-19.753-105.781 1.0067.84 B

ATOM 5541 CD2TYRB 76 -54.264-18.352-104.9441.0069.41 B

ATOM 5542 CE2TYRB 76 -54.418-19.505-105.6901.0068.68 B= ATOM 5543 CZ TYRB 76 -53.303-20.201-106.106 l,GΘ-68τ39 B

ATOM 5544 OHTYRB 76 -53.450-21.350-106.8501.00^68.32. B

ATOM 5545 C TYRB 76 -51.369-14.603-103.9961.0072.88 B

ATOM 5546 O TYRB 76 -50.439-15.198-103.451 1.0074.95 B

ATOM 5547 N GLUB 77 -51.457 -13:289-104.08-1 1.0073.68 B ATOM 5548 CA GLUB 77 -50.807-12.427-103.10! 1.0074.63 B

ATOM 5549 CB GLUB" 77 -49.519-11.836-103.6781.0072.74 B-

ATOM 5550 CG GLUB 77 -49.258 -10397-103.268 LOQ 72.09 B

ATOM 5551 CD GLUB 77 -47.907 -9.892-103.7360.0072.26 B

ATOM 5552 OElGLUB 77 -47.168-10.672-104.373 O.θθ 72.20 B- ATOM 5553-OE2GLUB 77 -47.584 -8.716-103.4670.0072.20 B

ATOM 5554 C GLUB 77 -51.737-11.309-102.6431.0075.85 B

ATOM 5555 O GLUB 77 -51.316-10.382-101.9521.0076.28 B

ATOM 5556 N PROB 78 -52.977-11.393-103.0321.0076.51 B

ATOM 5557 CD PROB 78 -53.276-11.091-104.443 1.0076.61 B ATOM 5558 CA PRO B 78 -54.085-11.029-102.143 1.0075.80 B

ATOM 5559 CB PROB 78 -55.243-10.797-103.115 TJOO- 75.82 _B

ATOM 5560 CG PRO B 78 -514.585-10353-104.3741.0076.15 B

ATOM- 5561- C PROB 78 -54.430 -12.155-101,1751.0074τ94 B.

ATOM 55620 PROS 78 -55.145-13.087-101:543 -LOO 74:θJθ~ B -ATOM 5563 N ALAB 79 -53:9-23-12.063-99.9501.0074:56 B

AXOM 5564 CA ALA-B- 79 -54.173-13.091-98.932 1.00-74.34 B

ATOM 556T CB ALA B- 79 -55.666--13τ080 -98.5201.0074:65 _B

ATOM 5566 C ALAB 79 -53.723 -14 J43 -99.1701.0073.65 B

ATOM- 5567 O ALAB 79 -54.534-15.427-99.4771.0073.27 B ATOM 5568 N TRPB 80 -52.416-14.763-99.0271.00-72.73 B

ATOM 5569 CA TRPB 80 -51.819-16.106-99.0991.0070.85 B

ATOM 5570 CB TRPB 80 -50.666-16.168-100.1071.0070.16 B

ATOM 5571 CGTRPB 80 -49.599-15.166-99.8221.0069.64 B

ATOM 5572 CD2 TRP B 80 -48.476-15.338-98.9461.0069.59 B ATOM 5573 CE2TRPB 80 -47.746-14.116-98.9501.0069.38 B

ATOM 5574 CE3 TRP B 80 -48.009-16.407-98.1561.0069.30 B

ATOM 5575 CDlTRPB 80 -49.519-13.889-100.3081.0069.39 B

ATOM 5576 NElTRPB 80 -48.404-13.249-99.7891.0069.33 B ATOM 5577 CZ2 TRPB 80 -46.573-13.933-98.1921.0069.58 B

ATOM 5578 CZ3 TRP B 80 -46.840-16.229-97.401 1.0069.01 B

ATOM 5579 CH2 TRP B 80 -46.134-14.995-97.4291.0069.74 B

ATOM 5580 C TRPB 80 -51.278-16.146-97.669 1.0069.95 B

ATOM 5581 O TRPB 80 -50.867-17.184-97.1461.0070.22 B ATOM 5582 N GLNB 81 -51291-14.946-97.0771.0068.65 B

ATOM 5583 CA GLN-B 81 -50.878-14.682-95.695 1.0066.69 B

ATOM 5584 CB GLNB 81 -50,405-13.224-95.548-1.0065.39 B

ATOM 5585 CG GLNB 81 -49.116-12.950-96.3201.0064.47 B

ATOM 5586 CD GLNB 81 -48.756-11.463-96.3721.0064.63 B ATOM 5587 OElGLNB 81 -49.619-10.611 -96.665 LOO 64.56 B

ATOM 5588.NE2 GLN B 81 -47.472-11.142-96.1051.0064.97 B

ATOM 5589 C GLNB Sl -52.1-OL -14.925 -94.815 1.0065.94 B

ATOM 5590 O GLNB 81 -51.997-14.961 -93.5871.0066.2-9 B

ATOM 5591 N ASNB 82 -53.253-15.078-95.4721.0064.93 B ATOM 5592 CA ASNB 82 -54.517 -15.346 -94.788 LOO 64.58 B

ATOM 5593 CB ASNB 82 -55.507 -14.184 -94.975 1.0064.45 B

ATOM 5594 CG ASN B .82 -55.346 -13.T-1O -93.898 1.0065.32 B

ATOM 5595 OBl-ASNB 82 -553.01-13.428-92^91 1.00-65,52 _B

ATOM- 5596 -ND2 ASN B^" 82 -55.268-11.832-94.3181=9065.10 B ATOM -5597-C ASN-382 -55.167

1.0064.-34 B

ATOM 5398 O ASN-B 82 -56.341-16.672-95.596-1.00-64,53 B

ATOM 5599 N PHEB 83- -54.388-^,731 -95.2361.0064.0S ^~B

ATOM 5600 CA PHEB 83 -54.896-19.047-95.6021.0063.81 BL

ATOM 5601 -CB PHEB 83 -53,910-19.802-96.495 1.0065.00 B ATOM 5602 CG PHEB S3 -53.864-19.315-97.9161.0066.37 B

ATOM 5603 CDl PHE B 83 -55.026-18.926-98.5761.0066.97 B

ATOM 5604 CD2 PHE B 83 -52.662 -19.307 -98.6201.0066.72 B

ATOM 5605 CEl PHE B 83 -54.992-18.538-99.9241.0066.50 B

ATOM 5606 CE2 PHE B 83 -52.618-18.924-99.963 1.0066.08 B ATOM 5607 CZ PHEB 83 -53.783-18.538-100.6141.0065.97 B

ATOM 5608 C PHEB 83 -55.098-19.834-94.312 1.0063.24 B

ATOM 5609 O PHEB 83 -54.177-19.943-93.4961.0062.79 B

ATOM 5610 N ALAB 84 -56.302-20.376-94.1341.0062.37 B ATOM 5611 CAALAB 84 -56.634-21.145-92.941 1.0061.04 B

ATOM 5612 CB ALAB 84 -57.897-21.958 -9J.178 1.0059.69 B

ATOM 5613 C ALAB 84 -55.471-22.060-92.5971.0060.47 B

ATOM 5614 O ALAB 84 -55.125-22.224-91.4271.0060.60 B

ATOM 5615 N ASPB 85 -54.856 -22.626 -9 J.6311.0059.57 B ATOM 5616 CA ASP B 85 -53.725-23.535-93.4691.0058.77 B

ATOM 5617 CB ASPB 85 -53.-647-24.474-94.677 LOD 58.50 B

ATOM 5618 CGASPB 85 -52.53« -25.499 -94.553 1.0058.22 B

ATOM 5619 ODl ASPB 85 -52.469-26.408-95.406 1.0058.02 B

ATOM 5620 OD2ASPB 85 -51.729-25399-93.6091.0058.06 B ATOM 562LC ASPB 85 -52.383-22.811-93.282 1.0058.05 B

ATOM 5622 O ASPB 85 -51.975-22.006-94.1191.0058.00 B

ATOM 5623. N PROB 86 -51.676-23.103-92.1761.0057.25 B

ATOM 5624 CDPROB 86 -52.109-23.982-91.068 1.0056.47 B

ATOM 5625 CA PROB 86 -50.382-22.487-91.8681.0055.96 B ATOM 5626 CB PROB 86 -50.212-22.790-90.3841.0055.63 B

ATOM 5627 CG PROB 86 -50.842-24.147-90.261 1.0055.32 B

A-TOM 562R- C PROB 86 -49.204 -22.997 -92.7061.0055. Ϊ6 B

ATOM 5629 O PROB 86 -48.350 --22.212 -93.124 JL00-55.12 B

ATOM 563JQrN GLNB 87 -49:157-24:307-92.943 LOO 54.06- B ATOM 5631 CA GLNB 87 -48.0.76 -24τ913 -93.721 JLOO 53.10 -B

JtTOM -5632 CB- GLN B- 8T -48.124-26.434 -93-.6201.0053.20 B

ATOM 5633 CG GLNB- 87 -47.661-26.948-92.281 1.0054.29^" B

ATOM 5634 CD GLNB 87 -47.323-28.413-92.323 1.0055.03 B

ATOM 5635 OElGLNB 87 -46.966-28,944-93.375 1.0054.19 B ATOM 5636 NE2 GLN B 87 -47.404-29.076-91.1741.0056.03 B

ATOM 5637 C GLNB 87 -48.101-24.520-95.1821.0052.82 B

ATOM 5638 O GLNB 87 -47.055-24.426-95.8191.0051.91 B

ATOM 5639 N LEUB 88 -49.304-24.310-95.7071.0052.94 B

ATOM 5640 CA LEUB 88 -49.483-23.920-97.0971.0052.51 B ATOM 5641 CB LEUB 88 -50.968-23.945-97.463 1.0052.31 B

ATOM 5642 CG LEU B 88 -51.375-23.696-98.9161.0051.90 B

ATOM 5643 CDlLEUB 88 -51.359-22.205-99.198 1.0051.78 B

ATOM 5644 CD2LEUB 88 -50.448-24.461-99.858 1.0050.60 B ATOM 5645 C LEUB 88 -48.934-22.521-97.2241.0052J5 B

ATOM 5646 O LEUB 88 -48.169 -22J227 -98.141 1.0053.01 B

ATOM 5647 N ARGB 89 -49.324-21.657-96.2921.0052.50 B

ATOM 5648 CA ARGB 89 -48.838-20.287-96.2901.0052.36 B

ATOM 5649 CB ARGB 89 -49.257-19.558-95.015 1.0053.45 B ATOM 5650 CG ARGB 89 -50.694-19.078-94.999 1.0056.38 B

ATOM 5651 €D ARGB 89 -51.015 -18.361 -93,692 1.0058.61 B

ATOM 5652 NE ARGB 89 -50.727 -19.213 -92LJ361.0061.93 B

ATOM 5653 CZARGB 89 -50.904-18.858-91.2641.0063.12 B

ATGM 5654 NHl ARGB- 89 -51.375 -17.656 -90.9561.0063.76 B - ATOM 5655 NH2 ARG B 89 -50.601-19.71-1-90.2961.0063.67 B

ATOM 5656 C ARGB 89 -47.318 -20.319 -96.375 1.0051.93 B

ATOM 5657 O ARGB 89 -46.722-19.646-97.2161.0052.75 B

ATOM 5658 N ALAB 90 -46,686-21.110-95.510 1.0051.05 B

ATOM 5659 CA ALA B 90 -45.231-21.199-95.521 1.0050.06 B ATOM 5660 CB ALAB 90 -44.754-22.219-94.498 1.0049.30 B

ATOM 5661 C ALAB 90 -44.712-21.554-96.9101.0048.77 B

ATOM 5662 O ALAB 90- -43.669 -2H057 -97349 1.004.7.78 B

ATOM .5663 N ILEB 91 -45.447-22,401-97.639 1.0047.76 B

ATOM 5664 CA-ILEΕ 91 -45.040 =22τ8T4 -98.976 1.0046.12 B ATOM 5665 CB BLEB 91 -45.7-65 -24.106-99.4001.0044_^36 B

ATOM 5666 CG2 ILE B 91- -45.402 -24.468.- 100r831 1. OO 43.40- B

ATOM 5667 CGlILEB 94 -45.3-56 -21.245 -98,468 1.0043.64 B

ATOM 5668 CDlILEB 91 -46.077-26.540-98.728 LOO 42.97 B

ATOM 5669 C DLEB 9-1 -45.257-21.736-100.039 1.0046.70 B ATOM 5670 O ILEB 91 -44.457-21.617-100.964 1.0047.53 B

ATOM 5671 N ILEB 92 -46.318-20.946-99.9141.0046.42 B

ATOM 5672 CAILEB 92 -46.579-19.893-100.8971.0046.92 B

ATOM 5673 CB ILEB 92 -47.989-19.267-100.713 1.0046.13 B

ATOM 5674 CG2ILEB 92 -48.169-18.071-101.643 1.0045.20 B ^

ATOM 5675 CGlILEB 92 -49.057-20.318-101.0081.0045.96 B

ATOM 5676 CDlILEB 92 -48.913-20.979-102.368 1.0044.82 B

ATOM 5677 C ILEB 92 -45.540-18.775-100,841 1.0047.32 B

ATOM 5678 O ILEB 92 -45,041-18.320-101.872 1.0047.67 B

.5. ATOM 5679^"N GLYB 93 -45.217-18.334-99.633 1.0047.82 B-

ATOM 5680 CA GLYB 93 -44.249-17.264-99.4741.0047.90 B

ATOM 5681 C GLYB 93 -42.856-17.673-99.8991.0047.72 B

ATOM 5682 O GLYB 93 -42.056-16.831-100.311 1.0047.80 B

ATOM- 5683 N ALAB 94 -42.562-18.965-99.7971.0047.39 B

10 ATOM 56S4 CAALAB 94 -41.247-19.482-100.1561.0047.90 B

ATOM 5685- CB ALAB 94 -41.007-20.830-99.492 1.0047.50 B

ATOM 5686 C ALAB 94 -41.099-19.598-101.6691.0048.08 B

ATOM 5687 O ALAB 94 -39.989-19.709-102.1871.0048.55 B

ATOM 5688 N VALB 95 -42.227-19.572-102.3721.0047.56 B

15 ATOM 5689^" CA VAL B 95 -42.230 -19.727-103.821 l.OO 46.85 JB

ATOM 5690 CB VALB 95 -43.375-20.646-104.2871.0046.92 B

ATOM 5691 CGlVALB 95 -43.196-21.019-105.750 1.0047.97 B

ATOM 5692 CG2 VAL B 95 -43.446-21.891-103.416 1.00-46.06 B

ATOM 5693 C VALB 95 -42.360-18.376-104.5181.0046.10 B

20 ATOM 5694 O VAL B 95 -41.969-18.225-105.6761.0045,83 B

ATOM 5695 N ARG-B 96 -42.810-17.400-103.7691.0045.4O B

ATOM 5696-CA ARG B 96 -42.858~16.064-J 04.2471-.0046.52 B

ATOM 5697 CB ARGB 96 -44.099-15.340-103.779 1.0047.87 B

ATOM -5698 CG ARG B-ftd -44.292 -15.226-102355 1.005OTIS -B

-2T ATOM 56-99^" CD ARGB 96^' -45.131 -14.079-101.929 l.OG 51.91 B

ATOM 5700 NE-ARGB 96 -44:30T -12.945-101.6801.0054.40- B

ATOM 5701 CZ ARGB 96- -44.690-11.709-101.783-1.0055.18 J3

ATOM 5702 NHl-ARGB 96 -43.813 -10.757-101.581 1.0055.24 B

ATOM 5703 NH2ARGB 96 -45.943-11.408-102.0881.0054.73 B

30 ATOM 5704 C ARGB 96 -41.643-15.296-103.9461.0046.01 B

ATOM 5705 O ARGB 96 -41.553-14.121-104.1501.0045.68 B

ATOM 5706 N THRB 97 -40.667-16.006-103.4701.0045.22 B

ATOM 5707 CA THRB 97 -39.344-15.436-103.249 1.0043.82 B

ATOM 5708 CB THRB 97 -38.795-15.865-101.875 1.0043.46 B ATOM 5709 OGl THRB 97 -39.387-15.060-100.8481.0043.97 B

ATOM 5710 CG2THRB 97 -37.314-15.536-101.7671.0043.77 B

ATOM 5711 C THRB 97 -38.375-15.847-104.3521.0042.65 B

ATOM 57120 THRB 97 -37.635-16.820-104.2091.0042.62 B ATOM 5713 N- LEUB- 98- -38.386-13.100-105.4511.0040.69 B

ATOM 5714 CA LEUB 98^"- -37.61245,465-106.633 1.0038.65 B

ATOM 5715 CB LEUB 98 -37.94344.517-107.788 1.0039.37 B

ATOM 5716 CG LEU B 98 -39.395-14.062-107.9821.0040.00 B

ATOM 5717 CDi LEU B -98- -39.507-13.285-109.281 1.00-39.79 B ATOM 5718 CD2 LEU B 98 -40.325-15.256-108.009 L0040.il B

ATOM 5719 C LEUB 98- -36.105 -15.494-106-.4191.0036.62 B

ATOM 5720- Q LEUB 98 -35.401-16.341-106.972 LOO 35.19 B

ATOM 5721 N GLYB 99 -35.599-14.567-105.623 1.0035.46 B

ATOM 5722 CA GLYB 99 -34.171 -14.550-105.386 LOG 35.63 B ATOM 5723 C GLYB 99 -33.432-13.971-106.5-721.0035.30 B

ATOM 57240 GLYB 99 -33.822-12.920-107.085 1.0035.61 B

ATOM 5725 N SERBlOO -32.372-14.641-107.018 1.0034.26 B

ATOM 5726 CA SERB 100 -31.606-14.130-108.148 1.0034.02 B

ATOM 5727 CB SERB 100 -30.299-14.913-108.3191.0032.58 B ATOM 5728 OG SERB 100 -30.528 -16.292-108.463 1.Of) 32.34 B

ATOM 5729 JC SERBlQO -32.403-14.135-109.4521.0035,22 B

ATOM 5730 O SERB^ Iθα -31.966-13.5:58-110.4-53 LOO 36.47 B-

ATOM- 5731 N ALAB IDl -33.579-14.766-109*433 1.0035.34 B

ATOM 5732. CA ALA^" B 101 -34.442 -14.838-110.605- 1:00-34.69 B ATOM 5733 CB-ALAB 101 -35.532-15..851-11.0.3721.0032.59 B

ATOM 57-34 C ALA B 101 -35.052-13.482-110:980-1-0035.10 B-

ATOM 5735 O -ALAB-IOl -35.535-13.307-112.091 1.0034.17 B

ATOM 5736 N ASN-B 102 -35.021-12.531-110.105 1.0036.09 B

ATOM 5737 CA ASNB 102 -35.556-11.262-110.413 1.0038.24 B ATOM 5738 CB ASNB 102 -35.732-10.476-109.1541.0040.55 B

ATOM 5739 CG ASN B 102 -36.581-11.121-108.1771.0043.37 B

ATOM 5740 ODl ASNB 102 -37.709-10.793-108.001 1.0043.56 B

ATOM 5741 ND2 ASN B 102 -36.016-11.979-107.465 1.0044.99 B

ATOM 5742 C ASNB 102 -34.614-10.481-111.2501.0038.50 B ATOM 5743 O ASNB 102 -34.892 -9.394-111.612 1.0038.68 B

ATOM 5744 N LEUB 103 -33.452-11.023-111.4771.0038.33 B

ATOM 5745 CA LEUB 103 -32.419-10.435-112.3301.0038.19 B

ATOM 5746 CB LEUB 103 -31.048-10.922-111.879 1.0038.90 B ATOM 5747 CG LEUB 103^" -30.458 -1-0.-51-0-110.540 1.0038.35 B

ATOM 5748 CDl LEUB 103 -29.236-11.377-110.306 1.0039:52 JB

ATOM 5749 CD2 LEU B 103 -30.077 -9.035-110.540 1.0037.04 B

ATOM 5750 C LEUB 103 -32.559-10.781-113.8041.0038.46 B

ATOM 5751 O LEUB 103 -32.816-11.926-114.145 1.0040719 B ATOM 5752 N PROB 104 -32.356 -9.804-114.701 1.0038.13^' B

ATOM -5753 CD PROB 104 -32.082 -&389-114.4071.0037.73 B

ATOM 5754 CA PRO B 104 -32.454-1OJ02O-116.1541.0037.4S B

ATOM 5755 CB PRO B 104 -32.084 -8.659-116.735 1.0037.53 B

ATOM 5756 CG PROB 104 -32.529 -7.722-115,6941.0038.10 B ATOM 5757 C PROB 104 -31.487 -1-1.U0-1W.631 1.003739 ^"B

ATOM 5758 O PROB 104 -30.482-11.395-115.9791.003S.14 B

ATOM 5759 N LEUB 105 -31.790-11.701-117.7-781.0037.39 B

ATOM 5760 CA LEUB 105 -30.965-12.759-118.352.1.0037.58 B

ATOM 5761 CB LEUB 105 -31.298-12.909-119.8391.0037.86 B ATOM 5762 CG LEUB 105 -30.881-14.144-120.6641.0037.80 B

ATOM^{^} 5763 CDl LEU B 105 -30.401 -13.654-122.037 l.(HF3&43 B

ATOM 5764 CD2 LEUB L05 -29.790 -14.968-119:972 1.003&90 B

ATOM 5-765 C LEU B 105 -29,471-12.472-1-18.2021.0037.40 B.

ATOM 5766 ---O LElTB 105 -28.716.-13-.266^"- 117.640 1.0037.08 B - ATOM 5767 N ALAB 106 -29.054-11.323-1-1-8,713 1.0037.50 B

MBQM 5768 CA-ALAB 106 -27^50-10.934-118.668 1.0037.81 B

ATOM 5769 CB ALA-3106 -27.465 -9τ603~ll 9-33.61.0039.21 B-

ATOM 5770 C ALAB106 -27.057-10.852-117.261 1.0037.11 B

ATOM 5771 O ALAB 106 -25.964-11.372-117.015 1.0035.72 B ATOM 5772 N LYS B 107 -27.794-10.344-116.311 1.0036.02 B

ATOM 5773 CA LYS B 107 -27.252-10.174-115.003 1.0034.66 B

ATOM 5774 CB LYS B 107 -28.053 -9.192-114.258 1.0032.76 B

ATOM 5775 CG LYS B 107 -27.463 -7.847-114.235 1.0032.04 B

ATOM 5776 CD LYS B 107 -28.495 -6.846-114.113 1.0032.22 B ,_„

ZJO

ATOM 5777 CE LYS B 107 -27.990 -5.562-113.6021.0032.16 B

ATOM 5778 NZ LYSB 107 -29.042 -4.713-113.0641.0033.81 B

ATOM 5779 C LYS B 107 -27.237-11.426-114.283 1.0034.84 B

ATOM 5780 O LYS B 107 -26.344 -11.6P9-113.561 1.0034.84 B ATOM 5781 N ARGB 108 -28.206-12.262-114Λ621.0034.86 B

ATOM 5782 CA ARGB 108 -28.226-13.599-113.9761.0034.64 B-

ATOM 5783 CB ARGB 108 -29.373-14.446-114.532 1.0035.23 B

ATOM 5784 CG ARGB 108 -30.768-14.052-114.0871.0037.13 B

ATOM 5785 CD ARGJB 108 -31.790-15.043-114.6361.0037.58 B ATOM 5786 NE ARGB 108 -33.166-14.586-114.4691.0038.63 B

ATOM 5787 CZ ARG-B 108 -34.224-15231-114.9471.0040.00 ^"B

ATOM 5788 NHl ARG B 108 -34.056 -L6.366-115.622 l.GΘ 40.70 B

ATOM 5789 NH2 ARG B 108 -35.445-14.739-114.761 1.0039.30 B

ATOM 5790 C ARGB 108 -26.933-14.306-114.311 1.0033.82 B ATOM 5791 O ARGB 1-08 -26.312-14.905-113.451 1.0035.13 B

ATOM 5792 N GLNB 1-09 -26.449-14.157-115.483 1.0033.17 B

ATOM 5793 CA GLNB 109 -25.322-14.882-115.8841.00.33.27 B

ATOM 5794 CB GLNB 1.09 -25.172-14.823-117.3841.0035.11 B

ATOM 5795 CG GLNB 109 -26.411-14.925-118.1821.0039.24 B ATOM 5796 CD GLNB 109 -26.188-14.747-119.6341.0041.81 B

ATOM 5797 OElGLNB 109 -26.946 -15.170-120.458 1.0042.07 B

ATOM 5798 NE2 GLNB 1O9- -25.137 -14Jl 1-11-9.945 LOO 44.57 B

ATOM 5799 C GL-N B 4-09 -24.106--14.343-11.5.278- 1.003-1.70 B

ATOM 5800 O GLNB-109 =23..140 -15^030-1137140 1.0029.58 _B -ATOM 58ϋt N GL-NB-HO -24.121 -13.060-414.989 1.0030.3.1 B

ATOM- 5802-CA GLNBIlO- -23:011-12.42-3-114.2761.002ST78 B

ATOM 5803 CB GtNTB 110 -23.194 -10.906-114.2181.00128.75 B

ATOM 5804 CG GLNB 110 -23,096-10.203-11-5:5621.00.29.71 B

ATOM 5805 CD GLNBIlO -23.256 -8.699-115.448 1.00.10.63 B ATOM 5806 OElGLNB 110 -22.498 -8.035-114.T49 1.0032.66 B^"

ATOM 5807 NE2 GLNB 110 -24.247 -8.155-116.1361.0030.94 B

ATOM 5808 C GLNBIlO -23.014-12.992-112.871 1.0028.29 B

ATOM 5809 O GLNBIlO -21.981-13.431-112.353 1.0027.01 B

ATOM 5810 N TYRBlIl -24.196-12.987-112.264 L0028.31 B _25?

ATOM 5811 CA TYRB 111 -24.377-13.527-110.930 1.0028.17 B

ATOM 5812 CB TYRB 111 -25.856-13.544-110.5641.0029.89 B

ATOM 5813 CG TYRB 111 -26.084-13.901-109.118 1.0033.73 B

ATOM 5814 CDl TYRB 111 -25.674-13.037-108.098 1.0035,22 JS ATOM 5815 CElTYRB 111 -25.836-13.378-106.758 1.0035.54 B

ATOM 5816 CD2 TYRB 111 -26.668-15.118-108.757 1.0034.56 B

ATOM 5817 CE2 TYR B 111 -26.834-15.465-107.420 1.0034.92 B

ATOM 5818 CZ TYRBlIl -26.412-14.590-106.428 1.0034.87 B

ATOM 3819 OH TYRBlIl -26.537-14.930-105.10« 1.0033.82 B ATOM 5820 C TYRBlIl -23.839-14.951-110.893 1.0027.36 B

ATOM 5821 O TYRB 111 -22.829-15.223-110.2461.0025.91 B

ATOM.5822 N- ASNB 112 -24.516-15.850-111.601 1.00^6.45 B

ATOM 5823 CA ASNB 112 -24.120-17.248-111.659 1.0026.53 B

ATOM 5824 CB ASNB 112 -24.935-18.014-112.7101.0026.18 B ATOM 5825 CG-ASNB 112 -26.433-17.886-112.514 1.0027.14 B

ATOM 5826 ODl ASNB 112 -26.923 -17.746-111.400 LOO 28.72 B

ATOM 5827 ND2 ASN B 112 -27.170-17.955-113.6061.0025.93 B

ATOM 5828 C ASNB 112 -22.638-17.420-111.9741.0027.84 B

ATOM 58290 ASNB 112 -22.025-18399-111.565 1.0029.00 B ATOM 5830 N ALAB 113- -22.056-16.481-112.7071.0028.57 B

ATOM 5831 CA ALAB 113 -20.647-16.600-113.053 1.0028.33 B

ATOM 5832 CB' ALAB 113 -20.361-15.859=114.3361.0028V02 B

ATOM 5833 C ALAB 113 -19.766 -16.076-lil.928- 1.0028.74 B-

ATOM 5834 O ALAB 113^" -4&699--16-.632-1-11-.6501.00125:93 -B- ATOM 5835 N LEUB 144- -2θr205 -_15..003-ll-L27-7 -1.0027.27 B

ATOM- 5836 CA LEUB 114 -1-9.436 -14.457-110.171 l.θ&23:99 B

ATOM- 5837 CB LEUB 114^" -26.1-08.-13.208-109:623 πJϋ2LΘ3 B

ATOM 58S8 -CG LEUB 114 -19.789 -11.931-11U3861.0018.99 B

ATOM 5839 CDl LEU B- 1-14 -20.527 -10.762-109.766 IJ)O 16.91 B ATOM 5840 CD2 LEU B 114 -18.292 -11.697-110.355 LOO 18.53 B

ATOM 5841 C LEUB 114 -19.330-15.516-109.085 1.0024.15 B

ATOM 5842 O LEUB 114 -18.307-15.628-108.4101.0023.67 B

ATOM 5843 N LEUB 115 -20.381-16.312-108.9301.0023.42 B

ATOM 5844 CA LEUB 115 -20.366-17.356-107.9261.0024.25 B ATOM 5845 CB LEUB 115 -21.774-17.933-107.7421.0023.35 B

ATOM 5846 CG LEUB 115 -22.804-16.946-107.1681.0024.76 B ATOM 5847 CDl LEUB 115 -24.191-17.539-107.2681.0024.18 B ATOM 5848 CD2 LEU B 115 -22.472-16.600-105.7221.0023.13 B ATOM 5849 C LEU-B 115 -19.355-18.462-108.236 1.0025.52 B

ATOM 5850 O LEUB-115 -18.517-18.779-107.395 1.0025.64 B

ATOM 5851 N SERB 116 -19.400-19.035-109.435 1.0025.75 B

ATOM 5852 CA SERB 116 -18.464-20.115-109.7501.0027.89 B

ATOM 5853 CB SERB 116 -18.857-20.908-111.0071.0029.85 B ATOM 5854 OG SERB 116 -19.204-20.089-112.1161.0032.83 B

ATOM 5855 C SERB 116 -17,023-19.685-109.885 1.0028.57 B

ATOM 5856 O SERB 116 -16.118-20.495-109.6651.0029.06 B

ATOM 5857 N ASNB 117 -16.789-18.424-110.241 1.0028.87 B

ATOM 5858 CA ASN-B 117 -15.413-17.950-110.3691.0029.76 B ATOM 5859^"CB ASN B 117 -15.355 -16.651-111.1651.0032.05 B

ATOM 5860. CG ASNB 117 -15.284-16.885-112.6571.0035.00 B ATOM 5861 ODtASNB 117 -14346-17.513-113.163 LOO 36.45 B ATOM 5862 ND2 ASN B 117 -16.279-16.375-113.375 1.0038.76 B

ATOM 5863 C ASN B-117 -14.772 -17.740-108.9991.0029.89 B- ATOM 5864 O ASNB 117 -13.598-18.068-108.8101.0030.05 B

ATOM 5865 N METB 118 -15.543 -17.199-108.049 L00^~28.94 B

ATOM 5866- CA METB: 11& -15.042-16.961-106.697 LΘO-27.77 B

ATOM 5867 CB METB 118 -16.190-16.267-105.828 1.0027,42 B

ATOM ^~ 3:868 CG METJ8118 -16.344-14.803-106.1361.00-25.18 -B ATOM 5869 SD METJL 118 -17.236-13.945-104.8121.0025.98: B

ATOM 5870 CE MET Bl L8 -1-8.861 -14.689- 104.875 1.00:21.78 B

ATOM 5871 C MET-B 118 -14,696 -18.304-106.0801.0027.16 B

ATOM 5872 O METB 118 -13.610 -18-.495-105.5371.0025.49 B

ATOM 5873 N SERB 119 -15.644-19.228-106.175 1.0027.22 B ATOM 5874 CA SERB 119 -15.475-20573-105.6501.0028.14 B

ATOM 5875 CB SERB 119 -16.713-21.403-105.9721.0028.24 B

ATOM 5876 OG SERB 119 -16.556-22.739-105.551 1.0028.89 B

ATOM 5877 C SERB 119 -14.239-21.214-106.2661.0028.98 B

ATOM 58780 SERB 119 -13.468-21.880-105.5771.0029.88 B ATOM 5879 N ARGB 120 -14.055 -20.996-107.566 1.00 29.36 B

ATOM 5880 CA ARG B 120 -12.914 -21.531-108.294 1.0029.46 B

ATOM 5881 CB ARG B 120 -13.060 -21.211-109.788 1.00 31.11 B

ATOM 5882 CG ARG B 120 -12.111 -21.983-110.714 1.00 33.43 B

5 ATOM 5883 CD ARG B 120 -10:970 -21.117-111.236 1.00 32.95 B

ATOM 5884 NE ARG B 120 -11.475 -19.949-111.950 1.00 34.34 B

ATOM 5885 CZ ARG B 120 -10.718 -18.908-112.281 1.00 37.43 B

ATOM 5886 NHl ARG B 120 -9.425 -18.906-111.964 1.00 38.82 B

ATOM 5887 NH2 ARG B 120 -11.253 -17.854-112.895 1.00 37748 B 0 ATOM 5888 C ARGB 120 -11.619 -20.933-107.746 1.00 28.97 B

ATOM 5889 Θ ARG B 120 -10.688 -21.653-107.400 1.00 28.04 B

ATOM 5890 N ELE B 121 -11.573 -19.610-107.662 _.1.0029.72 B

ATOM 5891 CA ELE B 121 -10.399 -18.907-107.166 1.00 31.47 B

ATOM 5892 CB ELE B 121 -10.676.-17.401-107.1:03 1.00 30.68 B 5 ATOM 5893 CG2 ILE B 121 -9.508 -16.673-106.461 1.0029.67 B

ATOM 5894 CGl ILE B 121 -10.930 -16.875-108.515 1.00 29.18 B

ATOM 5895 CDl ILE B 121 -11.517 -15.481-108.556 1,00 29.36 B

ATOM 5896 C ILE B 121 -9.963 -19.392-105.782 1.00 33.55 B

ATOM 5897 O DLE B 121 -8.773 -19.632-105.537 1.00 32.52 B 0 ATOM 5898 N TYR B 122 -10.936 -19.539-104.884 1.00 35.43 B

ATOM 5899 CA TYR B 122 -10.682 -19.978-103.515 1.00 36.24 B

ATOM 5900 CB- TYR B 122 -1-1.979 -19.933-102.703 1.00 36.82 B

ATOM 5901 CG TYRB 122- -11.792 -20.310-101,246 1.00 39.78- B

ATOM 59Θ2. CDl TYRB 122 -1L296 -19-.39-1-1Q&312 LOO 39.28 B 5- ATOM 5903 CEl TYRB 122 -11.078 -19.763 -98.983 LOO 39.78 B ATOM- 5904 CD2 TYRB: 122 -12.071 -21.605-100.806 L0040.82 B

ATOM ^5905- CE2 TYR B 122 -11.858 -21.981 -99.4.83 1.00^40:96 B

ATOM 5906 CZ TYRB 122 -11,360 -21.066 -98.578 1.00 40.89 B

ATOM 5907 OH TYRB 122 -11.115 -21.483 -97.286 1.004176 B O ATOM 5908 C TYRB 122 -10.070 -21.372-103.405 1.00 37.05 B

ATOM 5909 O TYRB 122 -9.058 -21.546-102.728 1.00 38.31 B

ATOM 5910 N SERB 123 -10.684 -22.360-104.062 1.00 37.62 B

ATOM 5911 CA SERB 123 -10.203 -23.747-104.024 1.00 37.93 B

ATOM 5912 CB SERB 123 -11.345 -24.715-104.345 1.00 38.45 B ATOM 5913 OG SERB 123 -12.397 -24.608-103.399 1.0041.52 B

ATOM 5914 C SER B 123 -9.046 -24.017-104.978 1.00 37.83 B

ATOM 5915 O SERB 123 -8.708 -25.170-105.234 1.00 39.02 B

ATOM 5916 N THR B 124 -8.435 -22.954-105.488 LOO 37,34 B

ATOM 5917 CA THRB 124 -7.327 -23.073-106.423 1.00 36.97 B

ATOM 591¥-CB THRΕ 124 -7.713 -22.463-107.788 1.00 37.35 B

ATOM 5919 OGl THRB 124 -8.637 -23.334-108.439 1.0036.59 B

ATOM 5920 CG2 THR B 124 -6.488 -22.248-108.677 1.00 37.71 B

ATOM 5921 C^" THR B 124 -6.076 -22.374-105.911 1.00 37.32 B

ATOM 5922 O THR B 124 -4.965 -22.749-106.269^" 1.DΘ 37.40 B

-ATOM 5923 N ALA-B 125 -6.265 -21.352- 1O5.083 LOG 37.57 B

ATOM 5924 CA ALA B 125 -5.149 -20.586-104.538 1.00 37.41 B

ATOM 5925 CB ALA B 125 -5.650 -19.606-103.505 1.00 38.08 B

ATOM 5926 C ALA B 125 -4.103 -21.500-103.924 1.0037.32- B

ATOM ^■5927 O ALA B 125 -4.435 -22.442-103.205 1:00 37.16 B

ATOM 5928 N LYS B 126 -2.862 -21.110-103.942 1.00 37.43 B

ATOM .5929 CA LYS B 126 -1.809 -21.991-103.613 1.0038.28- B

ATOM 5930 CB LYS B 126 -1.254 -22.480-104.905 1.00 38.47 B

ATOM 5931 CG LYS B 126 -1.642 -23.827-105.250 1.00 37.76 B

ATOM 5932 CD LYS B 126 -1.822 -23.997-106.684 CLOO 39.24 B

ATOM 5933 CE^" L-YS B 126 -3.159 -24.689-107.003 0.0040:00 B

ATOM 5934 NZ EYS B-126 -3.3-10 -25.229-108.4Θ0 LOO 41.87 B

A-TOM 5935 C LYS B 126- -0.780 -21.121-103.019 1.00 39.38 B

ATOM 5936 O LYS B 126 -0.830 -19:9.81-103.274 1.0Gθ9:61 B

A^TOM 5937 N VAL-B- 127 0.186 -21.641-102.274 1.00 40.25 B

ATOM 5938 CA VAL B-T27 L262 -20;850-1OT.68S^~ 1.0041.29^" B

ATOM .5939 GB VAL-B 127 1.231 -20:852-100.131 1.003875 B

ATOM 5940 CGl VAL B 12.7 2.331 -19.956 -99.595 1.00 34.32 B

ATOM 5941 CG2 VAL-B 127 -0.115 -20.381 -99.622 1.00 37.27 B

ATOM 5942 C VAL B 127 2.590 -21.439-102.128 L.0044.41 B

ATOM 5943 O VAL B 127 2.855 -22.605-101.874 1.0044.51 B

ATOM 5944 N CYS B 128 3.417 -20.634-102.787 1.0049.53 B

ATOM 5945 CA CYS B 128 4.728 -21.094-103.243 1.00 55.69 B

ATOM 5946 C CYS B 128 5.814 -20.453-102.401 1.00 59.00 B ATOM 5947 O CYS B 128 5.624-19.357-101.8591.0059.77 B

ATOM 5948 CB CYS B 128 4.961-20.726-104.7051.0058.13 B

ATOM 5949 SG CYS B 128 3.552-21.099-105.793 1.0064.19 B

ATOM 5950 N LEUB 129 6.956-21.132-102.3041.00-62.86 B ATOM .5951 CA LEUB-129 8.084-20.640-101.5141.0066.84 B

ATOM 5952 CB LEUB 129 8.643 -21.776-100.6541.0065.97 -B

ATOM 5953 CG LEUB 129 7.608-22.564-99.833 1.0065.39 B

ATOM 5954 CDlLEUB 129 6.840-23.550-100.716 1.0063.89 B

ATOM 5955 CD2 LEU B 129 8.326 -23.31-8^'-98.7361.0066.31 B ATOM 5956 C LEUB 129 9.177-20.088-102.4291.0070.03 B

ATOM 5957 O LEU B 129- 9.255-20.475403:5971:0074.38 B

ATOM 5958 N -PROB43J0 10.009-19.197-101.8981.00-72.61 B

ATOM 5959 CD PRO B 130 9.934-18.670-100.5241.0073.19 B

ATOM 5960 CA PRO B 130 -L0L985 -18.470-102.7161.0074.33 B ATOM 5961 CB PROB 130- 11.720-177606-101.6901:0073.98 B

ATOM 5962 CG PROB 130 10.729-17.398-100.6021.0073.61 B

ATOM 5963 C PROB 130 11.964-19.417-103.401 1.0076.13 B

ATOM 5964 O PROB 130 12.729-18.991-104.2671.0076.31 B

ATOM 5965 N ASNB 131 11.932-20.690-103.0201.0078.25 B ATOM 5966 CA ASNB 131 11.843-21.775-103.9901.0080.47 B

ATOM 5967 CB ASN-BTJl 11.625-23.113-103.281 1.0080.79 B

ATOM 5968 CG ASNB 131 T2T5-72-24.192-103.7681.0081.-80 B

ATOM 5969- ODl-ASNB 131 12.423-24.711-104.8741.008-2.36 B

ATOM^" 5970 ND2 ASNJB 131 13.553-24.535-102.9421.0082:32 B- ATOM 5971 C ASNB 131 1-0.742 -21.540-10570191.0082.02 B

ATOM 5972- O ASN-B 131 9.557-21.534-104.684 L00-83.75 B-

ATOM- 5973 N ALAB 132 H.L4L^21.347-106^".272 1.0082.27 B

ATOM 5974 CA-ALAB 132 10.229-21.502-107.3991=0082.57 B

ATOM 5975 CB ALA B 132 8.823 -2L806-106.905 1.0081.85 B ATOM 5976 C ALA B 132 10.709-22.593-108.3501.0083.10 B

ATOM 5977 O ALAB 132 10.441-22.545-109.551 1.0083.95 B

ATOM 5978 N ALA B 133 11.419-23.575-107.8061.0083.24 B

ATOM 5979 CA ALA B 133 11.193-24.971-108.1601.0082.83 B

ATOM 5980 CB ALAB 133 12.309-25.846-107.6101.0082.51 B ATOM 5981 C ALA B 133 9.837-25.349-107.572 1.0082.52 B

ATOM 5982 O ALAB 133 9.748-25.789-106.4261.0082.68 B

ATOM 5983 N ALAB 134 8.785-25.175-108.3641.0081.72 B

ATOM 5984 CA ALA B 134 7.421-25.228-107.850 1.0080.22 B

ATOM 5985 CB ALA-B 134 6.423-25.264-108.997 bøθ^'79.7.0 B

ATOM 5986 C ALA B 134 7.292-26.480-106.9901.0079.10 -B-

ATOM 5987 O ALAB 134 7.320-27.600-107.4991.0080.44 B

ATOM 5988 N ALAB 135 7.152 -26.282-1Θ5.683 1.0075.95 B

ATOM 59S9 CA ALA B 135 6.269-27.113-104.873 HM 72.56 B

ATOM 5990 CB ALAB 135 7.075-28.142-104.0961.0072.03 B^"

ATOM 5991 C ALAB 135 5.430-26.263-103.9241.0070.69 B

ATOM 5992 O ALAB 1.35. 5.774-26.102-102,7531.0072.07 B

ATOM 5993 N CYS B 136 4.330-25.722-104.4371.0066.42 B

ATOM 5994 CA CYS B 136 3.487-24.819-103.663 1.0061,77 B

ATOM 5995^" C CYS B 136 2.474-25.593-102.825 1.0057.93 B

ATOM 5996 O CYS B 136 2.082-26.705-103.179 1.0056.21 B

ATOM 5997 CB CYS B 136 2.765 -23.836-104J861.0062.97 B

ATOM 5998 SG CYS B 136 3.772-23.223-105.9571.0065.22 B

ATOM 5999 N TRPB 137 2.054-24.997-101.7141.0054.83 B

ATOM 6000 CA TRPB 137 1.148 -25.664-100;7801.0051.24 B

ATOM 6001 CB TRPB 137 1.509 -25.329-99.335^~ 1,0050.75 B

ATOM 6002 CG TRP B 137 2.909 -J25.621 -98.9551.0049:82- B

ATOM 6003 CD2TRPB 137 3.713-24.8-76-98.040 1.00-50.08:. B

ATOM -6004 CE2TRPB-137 4.959-25.533-97950 1.00:50r41 B ^" ATOM 6Θ05-CE3 TRPB 137 3.5Θ2.-23.716 -97.283 lτθθ 5Θ.57 B

ATOM 6006-CDi TRP B- 137 3.670-26,666-99^72 1,0050.20 B

ATOM 6007^"RElTRPB 137 4:995-26.624-98.775 Iτ00-50J22_ B

ATOM 6008 CZ2 TRP B 137 5.999-25.066-97.1321.005 hO3 B

ATOM 6009 CZ3 TRP B 137 4.537-23.245-96.4641.0050.81 B

ATOM 6010 CH2TRPB137 5.769-23.924-96.398 1.0Θ 51.17 B

ATOM 6011 C TRPB 137 -0.306-25.274-100.993 1.0049.56 B

ATOM 6012 O TRPB 137 -0.607-24.134-101.3421.0048.92 B

ATOM 6013 N SERB 138 -1.204-26.227-100.771 1.0047.87 B

ATOM 6014 CA SERB 138 -2.638-25.997-100.910 1.0047.70 B ATOM 6015 CB SERB 138 -3.320-27.248-101.451 1.0049.86 B

ATOM 6016 OG SERB 138 -3.276-28.303-100.498 1.0051.82 B

ATOM 6017 C SERB 138 -3.179-25.707-99.5181.0046.54 B

ATOM 6018 O SERB 138 -2.448-25.814-98,542 LOO 46.69 B

ATOM 6019 N LEUB 139 -4.453-25.353-99.4-101.0045.24 B^"

ATOM 6020 CA LEUB 139 -5.006-25.077-98.0921.0044.11 B

ATOM 6021 CB LEUB 139 -6.338-24.327-98.193 1.0042.44 B

ATOM 6022 CG LEUB 139 -6.878-23.775-96.8691.0040.14 B

ATOM 6023 CDl LEU B 139 -5..857^~-22.843 -96.235 1.0038.80 B

ATOM 6024 CD2 LEU B 139 -8.185-23.038-97.111 1.0040.13 B

ATOM 6025 C LEU B 139 -5.1-86-26.377-97.3061.0043.65 B

ATOM 6026 O LEUB 139 -4.782-26.467-96.1-50 LOO 45.06 B_

ATOM 6027 N ALAB 140 -5.820-27.339-97.917 1.0043.12 B

ATOM 6028 CA ALAB 140 -5.973-28.605-97.308 1.0043.98 B

ATOM 6029 CB- ALA B 140 -7.346-28.933-97.215 l.θθ 43.65 B

ATOM 6030 C ALA B 140 -5.277 -29.648 -98.0841.0044.72 B

ATOM 6031 O ALA B 140 -5.759-30:082-99.069 1.0043.99 B

ATOM 6032 N PROB 141 -4.105-30.049-97.6321.0045.40 B

ATOM 6033 CD PRO B 141 -3.626-31.230-98.3201.0045.17 B

ATOM 6034 CA PRO B 141 -3.791-30.166-96.240 1.0044.46 B

ATOM 6035 CB PROB 141 -3.424-31.569-96.170 1.0043.90 B

ATOM ^■6036 C&PRQJEU41 -2.766-3-1.716-97.259 LOB 43.51 B

ATOM 6037- C PROB_141 -2.557 -29.465 -95-388 1.00-43.98 B

ATOM 6038 O PRO1B-141 -2.198 -29. Il8tf_-94.931 1.0042T9O B

ATOM 6Θ39 N ASPBil:42 -1..811 -29r224-96.996 1.00-44.16 B

ATOM 6040 CA. ASPΕ 142 -0.531 -28:702=96.7181.00-44.45 B

ATOM 6041 CB ASP-B 142 0:T24 -28227 -97.9541.0O45Λ8- B

ATOM- 6042 CG ASP B 142 0.337-29.291-98.883 1.0047,41 B

ATOM 6043 ODl ASPB 142 1.095-30.166-98.562 1.0048.71 B

ATOM 6044 OD2 ASP B 142 -0.211-29-368-99.9521.0048.31^" B

ATOM 6045 C ASP B 142 -0.510-27.713-95.6481.0043.39 B

ATOM 6046 O ASP B 142 0.312-27.799-94.8141.0043.73 B

ATOM 6047 N LEUB 143 -1.395-26.739-95.6751.0041.46 B

ATOM 6048 CA LEU B 143 -1.206-25.487-94.9451.0037.84 B ATOM 6049 CB LEUB 143 -1.798-24.323-95.6921.0035.27 B

ATOM 6050 CG LEUB 143 -1.169-23.669-96.873 1.0032.82 B

ATOM 6051 CDl LEUB 143 -1.878-22.500-97.122 1.0031.32 B

ATOM 6052 CD2 LEU B 143 0.172-23.405-96.665 1.0032.19 B ATOM 6053 C LEUB 143 -1.946-25.624-93.695 1.0036.02 B

ATOM 6054 O LEUB 143 -1.502 -25:315^~-92.660 1.0034.20 B

ATOM 6055 N THRB 144 -3.080-26.224-93.825 1.0034.66 B

ATOM 6056 CA THRB 144 -3.879-26.628-92.6771.0035.14 B

ATOM 6057 CB THRB 144 -5.020-27.565-93.108 1.0033.95 B ATOM 6058 OGl THRB 144 -6.114-26.790-93.5971.0034.56 B

ATOM- 6059 CG2 THR B 144 -5.489-28.405-91.9561.0034.68 B

ATOM 6060 C THRB 144 -3.014-27.348-91.6271.0036.48 -B

ATOM 6061 O THRB 144 -3.182-27.134-90.423 1.0037.23 B

ATOM 6062 N ASNB 145 -2.090-28490-92.0921.0036.61 B ATOM 6063 CA ASN B 145 -L193 -28.938 -91.2101.0036.30- B

ATOM 6064 CB ASN B 145 -0.537-30.106-91.9591.0037.66 B

ATOM 6065 CG ASN B 145 -1.550 -3 L 107 -92.498 l.OΘ 39.36 B

ATOM 6066 ODl ASNB 145 -2.687-31.202-92.0141.0040.56 B

ATOM 6067 ND2 ASN B 145 -1.131-31.878-93.493 1.004033 B ATOM 6068 C ASNB 145 -0.091-28.073-90.623 1.0035.25 B

ATOM 6069 O ASN B 145 0.338-28,277-89.4901.0035.88 B

ATOM 6:070 N DLE B 146 0.385 -27.112 -91.4.0 L 1.0033.91 Ε

ATOM 6071 CA ILE-B 146 L444 -26=238-90.926 1.0032.64 B

ATΘM.Z6Q72 CB ILE B 146 1.985 -25.343 -9-E0541.003-1.27- B ATOM 6Θ73 CG2 ILE B 146 -3.176-24.548-91.5:521.00-31.1-1 B

ATOM 6074- -CGML-E F 146 27404 -26.2 LO-93.2441.0030.05 -&-

ATOM 6075 CDl ILE B 146 3.039 -25.442 -943-821,00:2X91^" B

ATOM 6076 C ILE B 146 0,909 -25.365 -89.800 1.0032,26 B

ATOM 6077 O ILEB 146 1.615-25.069-88.8371.0031.55 B ATOM 6078 N LEUB 147 -0.352-24.972-89.925 l.OΘ 31.71 B

ATOM 6079 CA LEUB 147 -0.975-24.140-88.9191.0030.28 B

ATOM 6080 CB LEUB 147 -2.044-23.248-89.5441.0028.79 B

ATOM 6081 CG LEUB 147 -1.532 -21.827 -89.7361.0027.68 B

ATOM 6082 CDl LEUB 147 -1.121-21.638-91.1771.0028.13 B ATOM 6083 CD2LEUB147 -2.611-20.842-89.3261.0027.77 B

ATOM 6084 C LEUB 147 -1.592-24.944-87.8071.0029.94 B

ATOM 6085 O LEUB 147 -2.200-24.388-86.9081.0030.96 B

ATOM 6086- N ALAB 148 -1.440-26.255-87.861 1.0029.46 B

ATOM 6087 CA ALAB 148 -2.016-27.092-86.829 IJOO 29.71 B

ATOM 6088 CB ALAB 148 -2.317-28.215-87.440 1.0029.09 B

ATOM 6089 C ALA B 148 -0.939-27.664-85.9441.0031.02 B

ATOM 6090 O ALAB 148 -1.172-27.877-84.7561.0034.09 B

ATOM 6091 N SERB 149 0.249-27.896-86.5021.0030.60 B

ATOM 6092. CA SERB 149 1.334 -28.488 -85.7211.0029.80 B

ATOM 6093 CB SERB 149 1.465-29.958-86.0921.0031.93 B

ATOM 6094 OG SER B -149 1.449-30.088-87.5021.0035.83 B

ATOM 6095 C SERB 149 2.702-27.832-85.8001.0027.68 B

ATOM 6096 O SERB 149 3.622-28.235-85.093 1.0026.70 B

ATOM 6097 N SERB 150 2.859-26.-846-86.6661.0026:48 B

ATOM 6098 CA SER B -150 4.139-26.174-86.751 1.0025.72 B

ATOM 6099 CB SERB 150 4.268-25.415-88.0621.0025.19 B

ATOM 6100 OG SERB 150 5.468-24.661-88.073 1.0025.83 B

ATOM 6101 C SERB 150 4.245- -25.194 -85.590 1.0026.29 B

ATOM 6102. O SERB 150 3.256-24.548-85.212 1.0027.01 B

ATOM 6103 N ARGB 151 5.443-25.085-85.021 1.0025.75 ^"B

ATOM 6104 CA ARG-B 151 5:673-24.179-83.902 LOO 24.93 B

ATOM 6105- -CB ARGB 151 6.048-24.966-82.652 1.0023,31 -B

-ATOM 6106 -GG ARGB L51 4.307=25.187-81.6891.0020,68 B

ATOM 6107 CD ARGBT151 3.105-25.788-82.3501.0OJJ7.57 B

ATOM 6108 NE ARG B- 151 21773-26.295-81.355 LOO 1-8.49 B

ATOM 6109 CZ ARG-B 151 1.506-26.607- -81.600 1.0020.11 B

ATOM 6110 NHl ARG B 151 0.741 -27.066 -80.6201.0049.83 B

ATOM 6111 NH2ARGB151 1.000-26.446-82.823 1.0019.20 B

ATOM 61L2 C ARGB 151 6.759-23.167-84.2191.0025.26 B

ATOM 6113 O ARGB 151 7.386-22.605-83.315 1.0025.50 B

ATOM 6114 N SERB 152 6.976-22.942-85.511 1.0025.18 B

ATOM 6115 CA SERB 152 7.970-21.979-85.974 1.0025.84 B

ATOM 6116 CB SERB 152 8.627-22.487-87.2461.0025.77 B ATOM 6117 OG SERB 152 9.677-21.633-87.630 1.0029.32 B

ATOM 6118 £ SERB 152 7.200-20.693-86.2591.0025.83 B

ATOM 6119 O SERB 152 6.311-20.677-87.1071.0026.18 B

ATOM 6120 N TYRB 153 7.520-19.618-85.5501.0025.42 B

ATOM 6121 CA TYRB 153 6.772-18.388-85.754 1.0026.24 B

ATOM 6122 CB^" TYRB 153 7.286-17.261-84.850 1.0025.10 B

ATOM 6123 CG TYRB 153 6.469-15.983-84.9341.0023.31 B

ATOM 6124 CDl TYRB 153 5.386-15.761-84.0821.0022.93 B

ATOM 6125 CEl TYRB 153 4.636-14.587-84.163 1.0021.05 B

ATOM 6126 CD2TYRB153 6,-774-14:999-85.8771.0022.03 B

ATOM- 6127 CE2TYRB153 6.027-13,831-85.969 1.0020.86 B

ATOM 6128 -CZ TYRB 153 4:967-13.632-85.1091.0020.89 B

ATOM 6129 OH TYRB 153 4.252-12.469-85.201 1.0021.99 B

ATOM 6130 C TYRB 153 6.871-17.970-87208 1.0027.73 B

ATOM -6131 O TYRB 153 5.866 -17.583- -87.8191.0028.80 B-

ATOM 6132 N ALAB 154 8.077-18.061-87.765 1.0027.76 B

ATOM 6133 CA ALAB 154 8.302-17.691-89.161 l.OO 26.90 B

ATOM 6134 CB ALAB 154 9.771-17.818-89.501 1,0024.70 B

ATOM 6135 C ALAB 154 7.467-18.530-90.1381.0027.11 B

ATOM 6136 O ALA B -154 6.706-17.982-90.9401.00.27.43 B

ATOM 6137 N METB 155 7.598-19.852-90.071 1.0027.29 B

ATOM -6.-13-8 CA METB 155 6.8-52 -2Q..713 -90.981 1.0029.02- B

ATOM 6133-CB-METB 155 7.225-22.170-90.741 1.0031.49 B

ATOM 6-140 CG- ME-ΕJB L5:5 6.692 -23rl29 -91.795 1.00-35.56: B

ATOM- 6Rl SD MET B^' 155 7.652 -24.678 -91.8T4 L0042.1Λ B-

ATOM- 6142- CE -MET B 155 7T269--25.399 -90.1.751.0Θ3&82 B

ATOM 6143 C METB-T5Ϊ5 5.340-20.518-90.8551.O028.34 B

ATOM 6144-O METB 155 4.612-20.551-9-1.8521.0028.97 B

ATOM 6145 N LEUB 156 4.867-20.311-89.630 1.0027.74 B

ATOM 6146 CA LEUB 156 3.445-20.086-89.399 1.0026.72 B

ATOM 6147 CB LEUB 156 3.152-20.074-87.8921.0026.42 B

ATOM 6148 CG LEUB 156 3.191-21.449-87.193 1.0026.17 B

ATOM 6149 CDl LEUB 156 3.188-21.285-85.691 1.0026.48 B

ATOM 6150 CD2LEUB156 1.981-22.275-87.618 1.0026.59 B ATOM 6151 C LEUB 156 3.028-18.763-90.0571.0026.46 B

ATOM 6152 O LEUB 156 1.985-18.684-90.699 1.0027.74 B

ATOM 6153 N LEUB 157 3.858-17.733-89.9141.0025.37 B

ATOM 6154 CA LEUB 157 3.577-16.426-90.507 LOO 24.75 B

ATOM 6-155 CB^" LEU-B 157 4.636 -15.411 -90.Q571.0023.32 B

ATOM 6156 CG LEUΕ 157 4.623-13.992-90.644 1.0021.40 B

ATOM 6157 CDl LEUB 157 3.377-13.258-90.1881.0020.32 B

ATOM 6158 CD2LEUB157 5.883 -13.241 -90.215 1.0018.46 B

ATOM 6159 C^" LEU-B-157 3.576-16.51-8-92.031 LOO 25.81 B

ATOM 6160 O XEUBT57 2.756-15.892-92.7071.0026-08 B

ATOM 61-61 N PHE-B 158 4:502-17.306-92.5701.00-27.08 B

ATOM 6162 CA PHEB 158 4.614-17.-468-94.0171.00-27.48 B

ATOM 6163 CB PHE B 158 5.850-18.297-94.363 1.0029.80 B

ATOM 6164 CG PHE B 158 6.301-18.147-95.7901.0032.74 B

ATOM 6165 CDl PHE B 158 7.000-17.009-96.192 1.0033.67 B

ATOM 6166 CD2PHEB158 6,001-19.125-96.7391.0033.80 B

ATOM 6167 CEl EHE B 158 7.393-16.838-97.5151.0034.00 B

ATOM 6168 CE2PHEB158 6.392-18.968-98.073 1.0034.45 B

ATOM 6169 CZ PHEB 158 7.088-17.821-98.460 1.0034.54 B

ATOM 6170 C PHE B 158 3.370-18.117-94.626 LOO 25.89 B.

ATOM ^■6171 Θ PHEB 158 2:882-17.674-9-5.661 1.00.26.78 B

ATOM 6172 N- ALA-B 159 27862-19.162-93.9-78 LOO 23.43 B

ATOM 6173-GA ALAB 15-9 1.672 -t9.847 -94.457 1.0022.10 B

ATOM-. =6:174 CB-ALAB 159 1.529 -21.175 -93r74.6_L0020.41 B

ATOM 6175 ^"C AtA B- 159 0:41-8-18.999-94:241 L0022.ll B

ATOM 6116^' O ALAB 159 -0:493- m.O16 -35,070 - 1.0022705 B

ATOM 61-77-N TRE-B- 16G 0.371-18.265 -93.129= 1.0021.46 B

ATOM 6178 CA TRP B 160 -0.781 -17.419 -92.8221.0020.90 B

ATOM- -6179 CB TRP B L60 -0.690-16.818-91.4121.0020.05 B

ATOM 6180 CG TRPB 160 -1.927-16.015-91.035 1.0019.37 B

ATOM 6181 CD2TRPB160 -2.161 -14.622 -91.279 1.0017.74 B

ATOM 6182 CE2TRPB160 -3.465 -14.330 -90.823 1.0017.70 B

ATOM 6183 CE3 TRP B 160 -1.397-13.591-91.8401.0017.57 B

ATOM 6184 CDl TRP B 160 -3.067-16.491-90.4561.0019.51 B ATOM 6185 NEl TRPB 160 -3.995 -15.489 -90.3241.0017.96 B

ATOM 6186 CZ2TRPB160 -4.022-13.056-90.9081.0017.76 B

ATOM 6187 CZ3 TRPB 160 -1.951-12.319-91.9241.0017.92 B

ATOM 6L88 CH2 TRP B 160 -3.252-12.064-91.4591.0017.97 B-

ATOM 6189 C TRP B 160 -0.860-16r279 -93.821 1.0020.4T B

ATOM 6190 O TRPB 160 -4.884 -16.075^-94.4651.0019.77 B

ATOM 6191 N GLUB 161 0.223-15.523-93.9261.0020.40 B

ATOM 6192 CA GLUB 161 0.272 -14.405 -94.8601.0021.66 B

ATOM 6193 CB GLUB 161 1.640 -L3-.730 -94.7921.0021.38 B

ATOM 6194 CG GLUB 161 1.765-12.498-95.661 1.0021.93 B-

ATOM 6195 CD GLUBM 3.1-89-11.970-95:726 1.00-23,97 B

ATOM 6196 OEl GLUJB 161 3.354-10.792 -96.099 1.0024.83 J3-

ATOM 6197 OE2GLUB 161 4.139-12.727-95.420 1.0024.15 B

ATOM 6198 C GLUB 161 0.028-14,933.-96.275 1.0022.07 B

ATOM 6199 O GLUB 161 -0.868-14.465-96.981 1.0022.73^" B-

ATOM 6200 N GLYB 162 0.834-15.920-96.6691.Θ020.98 B

ATOM 6201 CA GLYB 162 0.727-16.524-97.9801.0020.61 B

ATOM 6202 C GLY B 162 -0.681-16.900-98.3841.0021.17 B

ATOM 6203 O GLYB 162 -1.123-16.563-99.481 1.0020.65 B

ATOM 6204 N TRPB 163 -1.399-17.598-97.516 1.0021.90 B

ATOM 6205 CA TRPB 163 -2.761.-17.-982 -97.855 1.00-22.40 B

ATOM 6206 CB TRPJ31.63 -3.347 -1&933 -9-6.791 1.00-21.14- B

ATOM 6207 CG TRPB-163 -4.831 -WT-M 8 -96^949 1.0021.06 B-

-ATOM 6208 CBΪTRPB 163 -5.5Θ8 -19^79« -98.0181.0020.23 B ^" ATOM 6209 CE2 TRP B 163 -6.902- 19.6-1-2 -97.820 1.0019:98 B

ATOM 6210 CE3TRPB 163 -5.076^~-20.541 -99.1271.0018τ38^~ B-

ATOM 6211 CDl TR3P-B 163 -5.812-1-8^:573-96.168 1.0021.95 B

ATOM 6212 NEl-TRPB 1.63 -7.058 -18.863- -96.684 LOO 21.61 -B

ATOM 6213 CZ2TRPB-161 -7.864-20.143-98.6921.0018,48 B

ATOM 6214 CZ3 TRP B 163 -6.03T-2-1.065 -99.991 1.0018.64 B

ATOM 6215 CH2TRPB163 -7.414-20.861-99.7661.0019.27 B

ATOM 6216 C TRPB 163 -3.658-16.751-98.0291.0022.99 B

ATOM 6217 O TRPB 163 -4.404-16.653-98.9991.0024.04 B

ATOM 6218 N HIS B 164 -3.537-15.776-97.1871.0023.15 B ATOM 6219 CA HIS B 164 -4.349-14.597-97.2021.0023.12 B

ATOM 6220 CB HIS B 164 -4.145-13.864-95.8841.0020.50 B

ATOM 6221 CG HIS B 164 -4.945-14.411-94.7731.0020.07 B

ATOM 6222 CD2HISB164 -6.091-13.993-94.2491.0018.68 Ε

ATOM 6223 NDI HIS B 164 -4.635 -15.560 -94.12S 1.0021.35 B

ATOM 6224 CEl HIS B 164 -5:544 -15.792 -93.2171.0019.71 B

ATOM 6225 NE2 HIS B 164 -6.443 -14.856 -93.2741.0017.81 B

ATOM 6226 C HIS B 164 -4.101-13.664-98.3221.0023.62 B

ATOM 6227 O HISB 164 -4.974-12.997-9877791.0024.09 B

ATOM 6228 N ASNB 165 -2.882 -13.534 -98.7371.0022.79 B

ATOM 6229 CA ASNB 165 -2.616-12.723-99.8961.0022.21 B

ATOM 6230 CB ASNB 165 -1.128-12.4-17-99.9891:0021.27 B

ATOM 6231 CG ASNB 165 -0.684-11.421-98.955 1.0021.74 B

ATOM 6232 ODl ASNB 165 -1.447-10.537-98.5591.0021.90 B

ATOM 6233 ND2ASNB165 0.564 -11.539 -98.518 1.0024.17 B

ATOM 6234 C ASNB 165 -3.099 -13.453-101.1561.0023.12 B

ATOM 6235 O ASNB 165 -3.767-12.873-102.014 LOO 23.53 ^"B

ATOM 6236 N ALAB 166 -2.784-14.739-101.2401.0022.60 B

ATOM 6237 CA ALA B 166 -3.147-15.547-102.3841.0022.62 B - ATOM 6238 CB ALAB 166 -2.501-16.892-102.258 1.0021.38 B

ATOM 6239 C ALA B 166 -4.641-15.72:1-102.605 1.0023,93^" B

ATOM 6240- O ALAB-166 -5.1-02 -13L771-103.741 1.0024.10 B-

ATOM 6241 N ALA-B 167 -^■5:407 -15J796-10J.5261-.0025.5S B

ATOM 6242 CA ALA B t67_ -6r84&-16.G2^~6-101.641 1.0026,26 B:

ATOM__6243- BB ALA-B 167 -7.300-16,944-100.501 LOJO 24.91 B

ATOM 6244 C ALAB-1^7 -7.787 -14^12-101.719- 1.00^"26.-74- -B

ATOM 6245 O- ALA BT.67 -8.716-14.784-iO2τ541 1.0026.76 B^~

ATOM 6246 N GLYB 168 -7.559 -13.814-100.874 LOO 26.24 B

ATOM 6247 CA GLYB L68 -8.452 -12.671-100.8641.0026:08 B

ATOM 6248 C GLYB 1-68 -8.210-11.533-101.8441.0026.01 B

ATOM 6249 O GLYB 168 -9.159-10.874-102.2801.0026.61 B

ATOM 6250 N DLE B 169 -6.953-11.280-102.1861.0024.10 B

ATOM 6251 CA DLE B 169 -6.652-10.187-103.0941.0021.99 B

ATOM 6252 CB DLE B 169 -5.116-10.073-103.3061.0020.82 B _m

ATOM 6253 CG2 ILE B 169 -4.799 -9.121-104.457 1.0020.39 B

ATOM 6254 CGl ELE B 169 -4.466 -9.588-102.005 1.00 18.16 B

ATOM 6255 CDl ELE B 169 -2.976 -9.386-102.087 1.00 16.47 B

ATOM 6256 C ELE B 169 -7.390 -10.305-104.436 1.0022.26 B ATOM 6257 0 ELE B 169 -8.159 -9.417-104.817 1.0022.63 B

ATOM 6258 N PRO B 170 -7.202-11.421-105.146 1.0021.78 B

ATOM 6259 CD PRO B 170 -6.507 -12.653-104.734 1.0021.83 B

ATOM 6260 CA PRO B 170 -7.859 -11.611-106.440 1.00 22.05 B

ATOM 6261 CB PRO B 170 -7.226 -12.895-106.943 1.0021.58 B ATOM 6262 CG PRO B 170 -7.085 -13.678-105.683 1.0020.96 B

ATOM 6263 C PRO B 170 -9.371 -11.734-106.354 1.0023.00 B

ATOM 6264 O PRO B 170 -10.080 -lL543-107.3θ9 1.0025.16 B

ATOM 6265 N LEU B 171 -9.857 -12.042-105.164 1.0022.86 B

ATOM 6266 CA LEU B-171 -11.273 -12.257-104.940 1.0022.27 B ATOM 6267 CB LEUB 171 -11.400 -13.250-103.782 1.00 23.41 B

ATOM 6268 CG LEU B 171 -12.583 -14.200-1-03.599 1.0025.26 B

ATOM 6269 CDl LEUB 171 -13^098 -14.707-104.957 1.0025.82 B

ATOM 6270 CD2 LEU B 171 -12.123 -15.348-102.689 1.0022.07 B

ATOM 6271 C LEUB 171 -12.066 -10:988-104.656 1.0021.04 B ATOM 6272 0 LEU B- 171 -13.266 -10.946-104.884 1.00 19.44 B

AT-OM 6273 N LYS B 172 -11.416 -9.919-104.431 1.0021.74 B

ATOM 627# CA LYS B 172 -12J3S9 -8.783-1037962 1.00-22.67 B

ATOM 6275 CB^' LYS B-172 -UL080" -7^31-103.431 LOO 24.19 B.

ATOM 6276 CG LYS B- 172 -TT.627 -6:647-102.764X0024.87 B ATOM 6277 CD: LYS=B 172 -KL595 -5:91-8-162,143 1.0028.85 B-

ATOM 6278- CE ^"LYS B 172 -11.144 -4.753-101.628- fcΘO^ LU B-

ATOM 6279 NZ LYS B- 172 -10321 -4.242~lO0.53O^~1.0033.52 B

ATOM 6280 C LYS B 172 -12.865 -8.-103-104.966 1,00 22.23 B

ATOM 6281 O LYS-B 172 -13.959 -7.787-104.738 1.00 20.81 B ATOM 6282 N PRO B 173 -12.288 -7.811-106.102 1.0021.45 B

ATOM 6283 CD PRO B 173 -10.959 -8.201-106.600 1.0020.21 B

ATOM 6284 CA PRO B 173 -13.072 -7.175-107,166 1.0020.49 B

ATOM 6285 CB PROB 173 -12.108 -7.175-108.349 1.00 19.32 B

ATOM 6286 CG PRO B 173 -11.219 -8.343-108.063 1.00 18.88 B _m

ATOM 6287 C PROB 173 -14.386 -7.916-107.444 1.0020.61 B

ATOM 6288 O PROB 173 -15.427 -7.292-107.680 1.0019.71 B

ATOM 6289 N LEUB 174 -14.336 -9.243-107.3771.0020.23 B

ATOM 6290 CA LEUB 174 -15.522-10.048-107.6181.0021.74 B ATOM 6291 CB- LEUB 174 -15.132-11.513-107.8241.0020.66 B

ATOM 6292 CG LEUB 174 -14.030-11.848-108,8251.0019.15 B

ATOM 6293 CDl LEUB 174 -14.028-13.343-109.045 1.0019.68 B

ATOM 6294 CD2 LEU B 174 -14.272-11.157-110.141 1.0023.72 B

ATOM 6295 C LEUB 174 -16.581 -9.946-106.4961.0023.56 B ATOM 6296 O LEUB 174 -17.787^" -9.838-106.7881.0022.95 B

ATOM 6297 N TYRB. T75 - 16.151 -9:971-105.2261.0024.30 B

ATOM 6298 CA TYRB 175 -17.102 -9.898-104.113 1.0023.75 B

ATOM 6299 CB TYRB 175 -16.387 -9.979-102.756 1.0023.38 B

ATOM 6300 CG TYRB 175 -17.317-10.363-101.616 LOO 23.97 B ATOM 6301 CDlIYRB 175 -17.823-ll.661-10r.5151.0025.47 B

ATOM 6302 CEl TYR B- 175 -18.712-12.016-100.5091.0024.83 B

ATOM 6303 CD2 TYRB 175 -17.725 -9.428- 100.6681.0023.22 B

ATOM 6304 CE2 TYRB 175 -18.615 -9.773-99.6541.0024.06 B

ATOM 6305 CZ TYRB 175 -19.104-11.069-99.5871.0025.23 B ATOM 6306 OH TYR-B 175 -20.007 -11.429 -98τ619 1.0026.03 B

ATOM 6307 C TYRB 175 -17.936 -8.620- 104.1691.0023.95 B

ATOM 6308 O TYRB 175 -19.080-8:618-103.7421.0023.28. B

ATOM 6309 N GLUB 176 -1-7.365 -7.542- 104.700 1.00- 24JΩ B

ATOM 6310 CA_GLUB.-i76 -18.067 -6.268-104:798 1.00"23-.9t B- ATOM 6341 CB GLUB-176 -17.089 ~£Λ51-W5Λ 641-0025316 B

ATOWL -63126S- GLUB 176- -157842 -5.149:-104.314 W)O 26.82 B

ATOM- 6313 GB GLUB 176- -14.773 -4.231-104:863 1.0027.26 B-

ATOM 6314 OElGLUB 176 -15.1-36 -3.151-105.368 1.0026.04 B

ATOM 6315 OE2 GLUB 176 -13.576 -4.584-1Θ4.780 1.0028.08 B ATOM 6316 C GLUB 176 -19.171 -6.328-105.8401.0027.43 B

ATOM 63170 GLUB 176 -20.258 -5.801-105.6161.0027.23 B

ATOM 6318 N ASPB 177 -18.895 -6.953-106.986 1.0029.55 B

ATOM 6319 CA ASPB 177 -19.901 -7.067-108.042 1.0031.28 B

ATOM 6320 CB ASPB 177 -19.288 -7.587-109.3461.0034.46 B _2?2

ATOM 6321 CG ASP B 177 -18.276 -6.631-109.945 1.00 36.90 B

ATOM 6322 ODl ASP B 177 -18.446 -5.398-109.773 1.00 40.15 B

ATOM 6323 OD2 ASP B 177 -17.322 -7.113-110.602 1.00 36.84 B

ATOM 6324 C ASP B^' 177 -21.005 -8.019-107.606 1.00 31.25 B ATOM 6325 O ASP B 177 -22.193 -7.751-107.846 1.00 31.48 B

ATOM -6326 N PHE B 178 -20.604 -9.133-106.982 1.00 29.44 B

ATOM 6327 CA PHE B 178 -21.547 -10.136-106.481 1.0027.60 B

ATOM 6328 CB PHE B 178 -20.812 -11.285-105.781 1.0028.75 B

ATOM 6329 CG PHE B 178 -21.680 -12.045-104.809 1.00 30.90 B ATOM 6330 CDl PHEE 178 -22.544 -13.045-105.257 1.00 32.62 B

ATOM 6331 CD2 PHE B 178 -21.708 -11.690-103.454 1.00 30.92 B

ATOM -6332 CEl PHE B 178 -23.425 -13.671-104.371 LOO 33.94 B

ATOM 6333 CE2 PHE B 178 -22.585 -12.307-102.562 1.00 31.13 B

ATOM 6334 CZ PHE B 178 -23.445 -13.295-103.017 1.00 32.44 B ATOM 6335 C PHE B 178 -22.48S -9.498-105.469 1.0026.24 B

ATOM 6336 O PHEJB 178- -23.692 -9.750-105.47 '4 1.0026.05 B

ATOM 6337 N THRB 179 -21.911 -8:687-104.589 1.0024.87 B

ATOM 6338. CA THRB 179 -22.656 -8.015-103.544 1.0024.19 B

ATOM 6339 CB THRB 179 -21.695 -7.238-102.588 1.00 25.28 B ATOM 6340 OGl THRB 179 -20.697 -8.131-102.081 1.0027.02 B

ATOM 6341 CG2 THR B 179 -22.445 -67665-101.407 1.00 24.11 B

ATOM- 6342 C THRB 1.79 -23.707 -7.071-1 M.122 1.00J23.34" B

ATOM 6343 O THRB479 -24.850 -7.095-L03.692 1.00 23.51 B

ATOM^" 6344 N ALAB-1-8Θ --23.342 -6:255=1:05-. H05 1.00 22.63 B ATOM^" 6345 CA ALA B 180 -24305 -5.325-I05.6S8 1.0022.75 B

ATOM -6346 CB^" AEA B 180 -23:630 -4:433- 106JZQ3 1,00 22T36 B

ATOM 6347 C ALA B 1-80 -25,464- -6,050-10.6.347 1.00-23.53 B

ATOM 6348 O ALA B 180 -26.618 -5.641-106.215 1.0023.46- B

ATOM 6349 N LEU B 181 -25.154 -7.128-107.059 1.00 23.65 B ATOM 6350 CA LEUJB 181 -26.176 -7.884-107.757 1.00 25.45 B

ATOM 6351 CB LEU B 181 -25.529 -8.862-108.743 1.0025.20 B

ATOM 6352 CG LEU B 181 -25.015 -8.251-110.043 1.00 25.19 B

ATOM 6353 CDl LEU B 181 -24.421 -9.332-110.933 1.0027.40 B

ATOM 6354 CD2 LEU B 181 -26.167 -7.553-110.747 1.0025.23 B _m

ATOM 6355 C LEU B 181 -27.096 -8.631-106.816 1.00 27.21 B

ATOM 6356 0 LEU B 181 -28.319 -8.647-107.002 1.00 27.42 B

ATOM 6357 N SER B 182 -26.499 -9.255-105.805 1.0029.06 B

ATOM 6358 CA SER B 182 -27..249 -10.026-104.821 LOO 29.37 B ATOM 6359 CB SERB 182 -26.286 -10.661-103.818 1.00 29.10 B

ATOM 6360 OG SERB 182 -26.978 -11.548-102.961 1.00 30.68 B

ATOM 6361 C SER B 182 -28.246 -9.125-104.108 1.0029.03 B

ATOM 6362 O SER B 182 -29..281 -9.577 '-103. ,622 1.0029.67 B

ATOM 6363 -Η ASN-B 183 -27.926 -7.841-104.061 1.0028.04 B ATOM 63^~64 CA ASN B 183 -28.786 -6.871-103.422 1.00 28.99 B

ATOM- 6365 CB ASNB 183 -27.983 -5.649-102.991 1.0029.74 B

ATOM 6366 CG ASN B 183 -27.490 -5.747-101.567 1.00-28.04- B

ATOM 6367 ODl ASN B 183 -26.610 -6.531-101.250 1.00 27.45 B

AXOM 6368 ND2 ASN B 183 -28.070 -4.948-100.700 1.0030.48 B ATOM 6369 C ASN B 183 -29.908 -6.436-104.341 1.0030.37 B

ATOM 6370 O ASN B 183 -31.069 -6.413-103.9S8 1.00 30.99 B

ATOM 6371 N GLU B 184 -29.626 -6.008-105.536 1.00 31.98 B

ATOM 6372 CA GLU B 184 -30.646 -5.772-106.520 1.00 3235 B

ATOM 6373 CB GLU B 184 -30.008 -5.927-107.842 1.00 34.05 B ATOM 6374 CG GLU B 184 -29.957 -4.701-108.688 1.00 39.02 B

ATOM -6375 CD GLU B 184 -30.137 -4.981-110.129 1.00 42.29 B

ATOM 6376 OErGLU B 184 -29.260 -4.659410.92L 1.00 44.06 B

ATOM 6377 OE2 GLUB-184 -31.184 -5.514-110.462 1.0043.81 B

ATOM 6378 C GLU B 184 -3k593 -6.833-106.520-l.0O31.06 B ATOM 6379 O -GLUJB 184 -32.732 -6.656-106.559 1.00 29.94" B

ATOM 6380- N ALA^JδS -31.070 -7.993-1 ft6τ621 1.00 29:58 B

ATOM- 63Sl CA ALA B 185 -317899 -9.175-106.693- 1.00 30.05 B

ATOM 63^82 CB ALA-B-185 -31.033 -10.413-106.553 1.0027.67 B

ATOM 6383 C ALA B 185 -32.960 -9.152-105.605 1.00 31.55 B ATOM 6384 O ALA B 185 -34.140 -8.931-105.875 1.00 32.15 B

ATOM 6385 N TYR B 186 -32.521 -9.365-104.367 1.00 33.02 B

ATOM 6386 CA TYR B 186 -33.411 -9.403-103.212 1.00 33.17 B

ATOM 6387 CB TYR B 186 -32.644 -9.943-102.005 1.00 31.22 B

ATOM 6388 CG TYRB 186 -32.403 -11.432-102.089 1.00 30.76 B _2y4

ATOM 6389 CDl TYR B 186 -31.128 -11.944-102.310 1.00 28.96 B

ATOM 6390 CEl TYRB 186 -30.920 -13.318-102.429 1.0029.24 B

ATOM 6391 CD2 TYRB 186 -33.469 -12.334-101.987 1.00 31.10 B

ATOM 6392 CE2 TYRB 186 -33.270 -13.707-102.112 1.0029.79 B ATOM 6393 CZ T-YR-B-186 -31.998 -14.189-102.333 1.0029.11 B

ATOM 6394 OH TYR-B 186. -31.8-13 -15^".538^02.48O 1.0029.59 B

ATOM 6395 C TYR B 186 -34.167 -8.122-102.838 1.00 34.21 B

ATOM 6396 O TYR B 186 -35.185 -8.183-102.139 1.00 34.25 B

ATOM 6397 N LYS B^" 187 -33τ695 -065-103,293 1.00 35.08 B ATOM 6398 CA LYS B 187 -34.4O2 -5.739-102.973 1.00 37.37 B

ATOM 6399 CB LYS-B 187 -33.623 -4.502-1037435 .1.00 36.32 B-

ATOM- 6400- CG LYS-B 187 -34.275 -3.171-103.062 1.00 35.98 B

ATOM 6401 CD LYS B 187 -33.280 -2.022-103.192 1.00 38.33 B

ATOM 6402 CE LYSB 1-87 -33.958 -0,635-103.141 1.00 40.55 B ATOM 6403 NZ LYS B 187 -34.545 -O.23-5-1O1.S15 1.0040.56 B

ATOM 6404 C LYS B 187 -35.751 -5.815-103.664 LOO 38.78 B

ATOM 6405 Q LYS B 187 -36.677 -5.105-103.298 1.00 39.33 B

ATOM 6406 N GLNB 188 -35.862 -6.701-104.650 1.00 40.87 JB

ATOM 6407 CA GLN B 188 -37.115 -6.869-105.383 1.00 43.68 B ATOM 6408 CB GLN B 188 -36.859 -7.267-106.838 1.0047.68 B

ATOM 6409 CG GEN B 188 -3.6.407^" -6.108-107.715 1.00 53.40 B

ATOM 6410 CD GLN B Ϊ8S -36.456 -6.448-109:189 1.0Θ 56.48 B

ATOM 6411 OEl GLN-B-1-88 -37.532 -6.704- 1.0S.742 1.00 58.64 B_

ATOM 6412 JSfEZSLN BTfSS -35.291 -6.457-109.839 1.00-57.87 B ATOM 6413 C GLN B-IgS- -38.623

1.00 42.78 B

ATOM 6414 O -GLNJ318& -39.158 -8.086-105.1174- 1-00^"42.06- B

ATΘM 641T N ASP B-ΪS9¹ -3.7^13 -8.550-1-03.699 1.00^2.48 B

ATOM 6416. CA ASP B 189 -38.285 -9.535-102.958 1.00 42.31 B

ATOM 6417 CB ASP B 189 -37.408 -10.723-102.552 1.0044.31 B ATOM 6418 CG ASFB 189 -37.279 -11.767-103.663 LOO 46.37 B

ATOM 6419 ODl ASP B 189 -36.986 -11.387-104.818 1.00 48.84 B

ATOM 6420 OD2 ASP B 189 -37.467 -12.973-103.386 1.00 47.14 B

ATOM 6421 C ASP B 189 -38.839 -8.840-101.729 1.0041.85 B

ATOM 6422 O ASP B 189 -39.534 -9.448-100.913 1.0041.67 B ^

ATOM 6423 N GLYB 190 -38.519 -7.556-101.599 1.0041.14 B

ATOM 6424 CA GLYB 190 -39.022 -6.786-100.4771.0040.66 B

ATOM 6425 C GLYB 190 -38.062 -6.391-99.3701.0040.19 B

ATOM 6426 O GLY.B 190 -38.406 -5.538 -98.5521.0040.46 B ATOM 6427 N PHEB 191 -36.869 -6.980 -99.326-r.O0L39.44 B

ATOM 6428 CA PHE B 191 -35.913 -6.650 -98.265 LOO 39.16- B

ATOM 6429 CB PHEB 191 -35.064 -7.871-97.9191.0037.34 B

ATOM 6430 CG PHE B 191 -35.846 -9.141-97.7781.0036.52 B

ATOM 6431 CDl PHEB 191 -36.155 -9.909-98.8941.0036.27 Ε ATOM 6432 CD2 PHE B 191 -36.234 -9.597-96.5261.0037.00 B

ATOM 6433 CEl PHE B 191 -36.830 -11.111 -^8.773 1.0035.30 B-

ATOM 6434 CE2 PHEJB 191 -36,914-10:805-96.393 1.0036.88 B

ATOM 6435 CZ PHEB 191 -37.210-11.562-97.525 1.0035.73 B

ATOM 6436 C PHEB 191 -34.979 -5.474-98.5961,0039.60 B ATOM 64370 PHEB 191 -34.722 -5.185-99.765 1.0040.10 B

ATOM 6435 N THRB 192 -34.469 -4.805 -97.561 1.0039.43 B

ATOM 6439 CA THRB 192 -33.562 -3.677-97.761 1.00.39.58 B

ATOM 6440 CB THRB 192 -33.189 -3.014-96.4181.0039.81 B

ATOM 6441 OGl THRB 192 -34.284 -2.215-95.970 1.0040.57 B ATOM 6442 CG2 THRB 192 -31.951 -2.126-96.565 1.0040.02 B

ATOM 6443 C THRB 192 -32.279 -4.101-98r.465 1.0039 J5 B

ATOM 6444 O THRBJ92 -3L788 -3.394 -99.349 LOOF40-.5Ϊ B-

ATOM 6445 N ASP B 193- -31.733 -5=24& -98.0661.003.8:79 B

ATOM 64146- CA ASP-B 193- -30.516 --5.76&-9S.6621".0G 38.64 B AXOM- 6447- CB ASP B -1-93 -29.300 -5 J043 -98:053^" l.QO^'40.83 B ATOM -6448-CG ASPΕ-193 -29.242 -5T086--96.S751.0043.65 B

ATOM 6449 ΘD1 ASP B 193 -28.943 -6.169 -9-5.999- 1.00_44U5 B

ATOM 6450 OD2 ASP B 193 -29.497 -4.020-95.9681:0045.51 B

ATOM 6451 C ASPB 193 -30.405 -7.267-98.415 1.0038.55 B ATOM 6452 O ASP B 193 -31.216 -7.836-97.6801.0038.71 B

ATOM 6453 N THRB 194 -29.419 -7.915-99.032 1.0037.22 B

ATOM 6454 CA THRB 194 -29.271 -9.355-98.8521.0035.62 B

ATOM 6455 CB THRB 194 -27.979 -9.887-99.4981.0034.98 B

ATOM 6456 OGl THRB 194 -28.003 -9.610-100.898 1.0034.57 B _2?6

ATOM 6457 CG2 THR B 194 -27.862-11.399-99.301 1.0034.21 B

ATOM 6458 C THRB 194 -29.251 -9.682-97.3691.0034.80 B

ATOM 64590 THRB 194 -29.856-10.659-96.934 1.0033.93 B

ATOM 6460 N GLYB 195 -28.564 -8.547-96.5371.0033.67 B ATOM 6461 CA- GLYB 195 -28.470 -9.067-95.1681.0033.04 B

ATOM 6462 C GLYB 195 -29.797 -9.344-94.4941.0032.84 B

ATOM 6463 O GLYB 195 -29.929-10.276-93.703 1.0031.58 B

ATOM 6464 N ALAB 196 -30.797 -8.537-94.819 1.0033.00 B

ATOM 6465 CA ALAB 196 -32.109 -8.684-94.213 1.0032.24 B ATOM 6466 CB ALAB 196 -32.977 -7.503 -94.570 LQO 32.31 B

ATOM 6467 C ALAB 196 -32.816 -9.968-94.584 1.0031.89 B

ATOM 6468 O ALAB 196 -33.599-10.483-93.793 1.0031.31 B

ATOM 6469 N TYRB 197 -32.505-10.566-95.7091.0032.56 B

ATOM 6470 CA TYRB 197 -33.135-11.780-96.153 1.0033.18 B ATOM 6471 CB TYRB 197 -32.^36-12.070-97.642 1.0034.14 B

ATOM 6472 CG TYRB 197 -33.461-13.439-98.123 1.0036.36 B

ATOM 6473 CDlTYRB 197 -34.754-13.744-98.1251.0036.44 B

ATOM 6474 CEl TYRB 197 -35.157-14.935-98.521 1.0035.85 B

ATOM 6475 CD2TYRB197 -32.623-14.407-98.5871.0036.83 B ATOM 6476 CE2 TYR B 197 -33.063-15.585-98.9501.0035.86 B

ATOM 6477 CZ TYRB 197 -34.313 -15.835 -98.910 t.0035.59 B

ATOM 6478 OH TYRB 197 -34,721 -17.-042 -99.2Sl LOO 36.67 B

ATOM -6479- C TYRB 197 -32.562 -12.S45--95.3S1 1,0034.09- B-

ATOM 6480 O TYR-B 197 ~33.222J3.683 -94^922179035.63 B ATOM- 6481 -N IRPB 198- -3rl:287 -12.842 -95.245 1.0033.00 B

ATOM 6482 CA TRP B 198 -30.622 -4-3:894 -94.493- 1.0032.25 B

ATOM 6483 CB TRP B-19S- -29.mT-13.656 -94.507 £00-32:05 B

ATOM 6484 CG TRPB 198 -28.447-14.031-95.7901-003.1.14 B

ATOM- 6485 CD2TRPB-198 -27.037-14.135-96.0291.0030.3-9 B ATOM 6486 CE2 TRPB 198 -26.868-14.478-97.388 1.0030.02 B

ATOM 6487 CE3 TRP B 198 -25.900-13.970-95.2271.0029.21 B

ATOM 6488 CDl TRP B 198 -29.057-14.311-96.9771.0031.77 B

ATOM 6489 NEl TRPB 198 -28.117-14.581-97.9441.0030.04 B

ATOM 6490 CZ2 TRP B 198 -25.612-14.656-97.965 1.0030.26 B _2y7

ATOM 6491 CZ3 TRP B 198 -24.643-14.147-95.8021.0029.09 B

ATOM 6492 CH2 TRP B 198 -24.512-14.487-97.1601.0030.14 B

ATOM 6493 C TRPB 198 -31.140 -13.990 -93.0421.0031.82 B

ATOM 64940 TRPB 198 -31.522-15.065-92.5741.0030.97 B ATOM 6495 N ARGB 199 -31.161-12:858-92.3421.0031.66 B

ATOM 6496 CA ARGB 199 -31.626 -12.S19 -90.9541.0031.94 B

ATOM 6497 CB ARG B 199 -31.486-11.401-90.373 1.0029.67 B

ATOM 6498 CG ARG B 199 -30.057-10.882-90.2891.0028.31 B

ATOM 6499 CD ARGB 199 -29.983 -9.575-89.5191.0028:29 B ATOM 6500 NE ARG B 199 -30.568 -8.442-902301.0027.75 B

ATOM 6501 CZ ARGB 199 -29.909 -7.681-91.096 LOO 27.19 B

ATOM 6502 NHl ARG B 199 -30.520 -6.664 -91.6941.0026:48 B

ATOM 6503 NH2 ARG B 199 -28.634 -7.933-91.363 1.0027.27 B

ATOM 6504 C ARGB 199 -33.07-8 -13..277 -90.820 1.0033.00 B ATOM 6505 O ARGB 199 -33.416-14.023-89.9021.003-3.93 B

ATOM 6506 N SER B 200 -33.929-12.843-91.7461.0034.43 B

ATOM 6507 CA SERB 200 -35.345-13.186-91.7191.0035.08- B

ATOM 6508 CB SERB 200 -36.054-12.635-92.961 1.0035.45 B

ATOM 6509 OG SER B 200 -35.913- -13.512 -94.0651.0036.25 B ATOM 6510 C SERB200 -35.661-14.675-91.591 1.0035.18 B

ATOM 6511 O SERB 200 -36^".8Θ7 -15.031 -9L3541.0034.04 B

ATOM 6512 N TRPB-2Θ1 -34.663 -15.542.-91.750 1.0036.20- B

ATOM 6513 CA TRP B 201 -34r96J -16.983 -9 Iτ6271.00-37,86 B-

AΕΘM 6514 CB TRP B 201 -33:722-17.803-92.143 1.0038.05 _B ATOM 6515 CG TRP B-20.L -33τ521 -17.746-93.585 1.0038=87 B

ATOM j6516-CD2TRPB-2tH -32.269 -17 J66 -94.2601.0039:87 B

ATOM 6517 CE2 TRPB 201 -32.542 -17.771-95.645 l.W 40.25 B-

ATOM 6518 CE3 TRP B 201- -30.936-17.781-93.83.1 1.0040.79 -B

ATOM 6519 CDl TRP B 201 -34.482-17.738-94.551 1.0040.00 B ATOM 6520 NEl TRP B 201 -33,904-17.757-95.795 1.0040.01 B

ATOM 6521 CZ2TRPB201 -31.532-17.793-96.605 1.0040.89 B

ATOM 6522 CZ3 TRP B 201 -29.931-17.801-94.7871.0041.80 B

ATOM 6523 CH2TRPB201 -30.239-17.806-96.160 1.0042.01 B

ATOM 6524 C TRP B 201 -35.153-17.409-90.1881.0038.61 B _07C

Z/o

ATOM 65250 TRPB 201 -35.530-18.551-89.922 1.0039.72 B

ATOM 6526 N TYRB 202 -34.922-16.497-89.256 1.0039.16 B

ATOM 6527 CA TYR B 202 -35.130-16.813-87.8601.0040.18 B

ATOM 6528 CB TYRB 202 -33.932-16.346-87.041 1.0039.68 B ATOM 6529 CG TYR B 202 -32.645 -17.O16 -87.4461.0038.95 B

ATOM 6530 CDl TYRB 202 -31.819-16.449-88.413 1.0037.89 B

ATOM 6531 CEl TYRB 202 -30.646-17.072-88.805 1.0038.09 B

ATOM 6532 CD2TYRB202 -32.263-18.235-86.8791.0038.68 B

ATOM 6533 CE2 TYRB 202 -31.095-18.870-87.2661.0038.11 B ATOM 6534 CZ TYR B 202 -30.292-18.279-88228 1.0038.47 B

ATOM 6535 OH TYR B 202- -29 J24 -18.885 -88.605 1.0039.79 B

ATOM 6536 C TYR-B 202 -36.425-16.215-87.318 1.0041.53 B

ATOM 6537 O TYR B 202 -36.768-16.416-86.1501.0042.44 B

ATOM 6538 N ASNB 203 -J7.141 -15.492-88.1741.0042.63 B ATOM -6539 CA ASN B 203 -38.4-12 -14.887 -87.801 Ii)O 43.66 B

ATOM! 6540 CB ASN B 203 -39.557-15.891-87.9781.0046.12 B

ATOM 6541 CG ASN B 203 -39.639-16.459-89.3991.0049.37 B

ATOM 6542 ODl ASN B 203 -40.622-17.114-89.7591.0052.01 B

ATOM 6543 ND2 ASN B 203 -38.602 -16.224 -90.203 1.0050.79 B ATOM 6544 C ASN B 203 -38.453-14.385-86.373 1.0043.57 B

ATOM 6545 O ASN B 203 -39.097-147989-85.508 1.0043.53- B

ATOM 6546 N SER B 204 -37.752 -13.283 -86. S31.0042.83 B

ATOM -6547 CA SERB 204 -37.688 -12.673 -84.8141.0041.-81- B

ATOM 6548 :CB SERB 204 -36.568-13.367-84.0291.0043:12 B ATOM 6549 OG SERB 204 -36.252 -12.662 -82.8391.00-43τ97 B-

ATOM 6550 C SERB 204^ -3737A-11.196 -84.965- 170040.55 B

ATOM 6551 O SERB 204- -3.6.304-10,827-85.4481.0040.94^" B

ATOM 6552 N PRO B 205 -38.304-10.325-84.554 k0039.19 B

ATOM 6553 CD PRO B 205 -39.613-10.630-83.9591.0038.10 B ATOM 6554 CA PRO B 205 -38.104 -8.874-84.6571.0038.58 B

ATOM 6555 CB PRO B 205 -39.441 -8.298-84.191 1.0037.69 B

ATOM 6556 CG PRO B 205 -40.412 -9.430 -84.369 1.0037.85 B

ATOM 6557 C PRO B 205 -36.978 -8.434 -83.7441.0038.32 B

ATOM 6558 O PRO B 205 -36.622 -7.263-83.703 1.0039.81 B _m

ATOM 6559 N THR B 206 -36.421 -9.400-83.0241.0038.03 B

ATOM 6560 CA THRB 206 -35.373 -9.145-82.0501.0037.88 B

ATOM 6561 CB THR B 206 -35.898 -9.462-80.6271.0036.74 B

ATOM 6562 OGl THR B 206 -36,626-10.699-80.658 1.0035.80 B ATOM 6563 CG2 THRB 206 -36.812 -8349-80.118 1.0035.96 B

ATOM 6564 C THR B 206 -34.078 -9.924-82.2591.0038.21 B

ATOM 6565 O THR B 206 -33.137 -9.785-81.4741.0039.10 B

ATOM 6566 N PHE B 207 -34.020-10.736-83.3081.0037.36 B

ATOM 6567 CA PHE B 207 -32.835-11.548-83.5721.0036.22 B ATOM 6568 CB PHE B 207 -32.a44 -12.026 -85.025 LOO 33.23 B

ATOM 656-9- CG PHE B 207 -31.783 -13.039 -85.335 1:0031.17 B

ATOM 6570 CDl EHE B 207 -31.678-14.202-84.591 1.0030.77 JB

ATOM 6571 CD2PHEB207 -30.894-12.838-86.3791.0031.77 B

ATOM 6572 CEl PHE B 207 -30.706 -15.147 -84.881 1,00.30.69 B ATOM 6573 CE2PHEB207 -29.916 -13.786 -86.6771.00.31.30 B

ATOM 6574 CZ PHE B 207 -29.826-14.939-85.925 1.0030.78 B

ATOM 6575 C PHE B 207 -31.486-10.884-83.256 1.0036,80 B

ATOM 6576 O PHE B 207 -30.686-11.426-82.4921.0036.56 B

ATOM 6577 N GLU B 208 -31.256 -9.695-83.7491.003-7.54 B ATOM 6578 CA GLlIB 208 -29.992 -9.049-83.584 1.0039.43 B

ATOM 6579 CB GLUB 208 -29.908 -7.836-84.4841.0040.68 B

ATOM 6580 CG-GLU B 208 -29J13. -8.009 -85.822 1.0042.09 B

ATOM -6581 CD GLU B 208 -29.380 -6.835-86.731 l.OO 43.81 B

ATOM- 6582 OEtGEU-B 208 -28,443- -6M65 -86.871 L0.G.-45701 B ATOM- 6583 OE2 GLU B 208 -30.456 -6.677-87.311 1.0045.27 B

ATOM -6584 C GLU-B 208^" --29.775 -8.649=82.170 1.0040.19 B

ATOM 6585 O- GLUΕ-208 -28.686--S.735-81.7021-.G040.28 B-

ATOM 6586 N ASP B 209 -30.815 -8.178-81.489 1.0040.82 B

ATOM 6587 CA ASP B 209 -30.739 -7.821-80.0791.0040.77 B ATOM 6588 CB ASP B 209 -3L986 -7.054 -79.641 1.0043.28 B

ATOM 6589 CG ASP B 209 -31.907 -5.579-79.9821.0046.34 B

ATOM 6590 ODl ASP B 209 -32.879 -4.854-79.6771.0048.43 B

ATOM 6591 OD2ASPB209 -30.875 -5.140-80.5471.0046.31 B

ATOM 6592 C ASP B 209 -30.571 -9.071-79.225 1.0038.98 B _ocn

/oil

ATOM 6593 O ASP B 209 -29.816 -9.058-78.261 1.0039.16 B

ATOM 6594 N ASPB 210 -31.265-10.151 -79.573 1.0037.37 B

ATOM 6595 CA ASPB 210 -31.138-11.391-78.8181.0036.62 B

ATOM 6596 CB ASP B 210 -32.123-12.444-79.3321.0037.49 B ATOM- -6597 CG ASP B 210 -33.587 -12.061 -79.0791.0039.88 B

ATOM 6598 ODl ASP B 210 -13.859-11.339-78.095 1.0039.31 B

ATOM 6599 OD2 ASP B 210 -34.476-12.499-79.8491.0040.56 B

ATOM 6600 C ASP B 210 -29.703-11.934-78.8791.0036.08 B

ATOM -6601 G ASPBTTTO -29.190-12.451-77.891 1.0035.99 B ATOM 6602 N LEUB 2 IT -29.052-11.813-80.0291.0035.62 B

ATOM 6603 CA LEU B-211 -27:680-12.290-80.1691.0036.04 B

ATOM 6604 CB LEUB 211 -27:296-12.406-81.643 1.0037.00 B

ATOM 6605 CG LEU B 211 -27.922-13.485-82.5281.0035.90 B

ATOM 6606 CDl LEUB 211 -27.620-13.132-83.9761.0034.48 B ATOM 6607 CD2 LEU B^~211 -27.382-14,872 -82.1671.Θ033.46 B

ATOM 6608 C LEU B 211 -26.683 -L1.368 -79.4771.0036.87 B

ATOM 6609 O LEUB 211 -25.595-11.796-79.108 1.0035.98 B

ATOM 6610 N GLUB 212 -27.036 -10.094 -79.331 1.0039.18 B

ATOM 6611 CA GLUB212 -26.143 -9.151-78.658 1.0040.45 B ATOM 6612 CB GLUB 212 -26.628 -7.705 -78.E521.0042.04 B

ATOM 6613 CG GLLTB 2-12: -25.745 -6,666 -78.163 1.0048.37 B

ATOM 6614 CD-GLU B--2T2 -25:378 -5=474-79.0-601.0053.52 B

ATOM 661-5 OElGLUB 212 -2ά:8iO -5.711 -80.153 1.0056.77 B ATOM 66X6 OE2 GLU B 212 -25.642 -4.βS2_-78j674 1.0054.88- B ATOM 6617 -C GLU B- 2-12 -2€JM -3.517-77.171 1.0039.50 B

AT-OMT 6618 O GLUB 212 -25τO32 -9:677 -76r5941. OO 35:49 B ATOM 6619 N. HIS B 213 -27.288 -9.666 -76V5S): 1.0038.88 B

ATOM 6620-CA HTS B 213 -27.466-10.038-75.1761.0039.24 B

ATOM 6621 CB JHIS B 213 .28.980-10.139-74.8821.0043.25 B ATOM 6622 CG HIS B 213 -29.335 -10,486 -73.4581.0047.S0 B

ATOM 6623 CD2 HIS B 213 -29.975 -9.767-72.4991.0048.56 B

ATOM 6624 NDl HIS B 213 -29.094 -11.728 -72.9001.0048.92 B

ATOM 6625 CEl HIS B 213 -29.570-11.760-71.666 1.0047.69 B

ATOM 6626 NE2 HIS B 213 -30.109-10.583-71.398 1.0048.16 B _m

ATOM 6627 C BD[S B 213 -26.774-11.384-74.953 1.0037.53 B

ATOM 6628 O HIS B 213 -25.937-11.537-74.0641.0037.10 B

ATOM 6629 N LEUB 214 -27.117-12.353-75.7891.0035.78 B

ATOM 6630 CA LEUB 214 -26.557-13.694-75.703 1.0033.70- B ATOM 6631 CB LEU B 214 -27:016-14-513-76.9041.0033.63 B

ATOM 6632 CG LEU B 214 -27.573 -15.894-76.585 LOO 33.44 B

ATOM 6633 CDl LEU B 214 -28.120-16.529-77.8561.0033.30 B

ATOM 6634 CD2 LEU B 214 -26.483-16.742-75.9621.0033.97 B

ATOM 6635 C LEU B 214 -25.04143.713 -75.640^'1.0032.47 B ATOM 6636 O LEUB 214 -24.452-14.500-74.8951.0032.09 B

ATOM 6637 N TYRB 215 -2*407 -12.854--76.432 lτ003T.65 B

ATOM 6638 CA TYR E 215 -22.951 -12.819-76.453 1.0031:04 B

ATOM 6639 CB TYR B 215 -22.420-12.111-77.710 1.0029.26 B

ATOM 6640 CG TYR B 215 -20.9-19 -12J238 -77.8371.0026.68 B ATOM 6641 CDJ TYRB 215 -20.326-13.471 -78.ΪO61.0026.92 B

ATOM 6642 CEl TYRB 215 -18.936-13.627-78.0891.0026.11 B

ATOM 6643 CD2 TYRB 215 -20.083 -IL 157 -77.5681.0024.96 B

ATOM 6644 CE2 TYR B 215 -18.698 -11.297 -77.5491.0023.59 B

ATOM 6645 CZ TYRB 215 -18.128-12.536-77:8041.0025.37 B ATOM 6646 OH TYR B 215 -16.759-12.688-77.7261.0024.01 B

ATOM 6647 C TYRB 215 -22.-41.6.-12.134-75.2041.0031.50" B

ATOM 6.648 O IYRB 215 -21.336.-12:445-74.7501.0031:83 B

ATOM 6649 N GL-NB-216 -23.299-11.208-74.655 1.003-L21 B-

ATOM- 6650- CA GLN B-216. -22.845r4O.483 -73.4361.0030.57 B ATOM 6651 CB GLN B 216 -24:015 -9:621-72.950 - L0røL51 B_

ATOM 6652 CG GLN B 216 -24266 -8.317-73.6881.-80363)6 B

ATOM 66536D-GLNB-21-6 -23292 -7-212_-73.2941.0040.39 B

ATOM 6654 OEJ GLNJB 216 -23.049 -6.976 -72.1071.0043r7-8 B

ATOM 6655 NE2 GLNJB 21-6 -22.742 -6.513-74.2901.QO-42.il B ATOM 6656 C GLN B 216 -2Z524 -11.520 -72.3571.0029.90 B

ATOM 66570 GLNB216 -21.517-11.419-71.651 1.0028.79 B

ATOM 6658 N GLNB 217 -23.395-12.520-72.2441.0028.48 B

ATOM 6659 CA GLN B 217 -23.240-13.580-71.2651.0027.84 B

ATOM 6660 CB GLN B 217 -24.441-14.494-71.2861.0028.43 B ATOM 6661 CG GLN B 217 -25.720-13.838-70.9141.0031.93 B

ATOM 6662 CD GLN B 217 -26.849-14.835-70.8891.0035.29 B ATOM 6663 OEl GLN B 217 -26.775-15.847-70.1941.0036.05 B ATOM 6664 NE2 GLN B 217 -27.904-14.563-71.653 1.0038.08 B ATOM 6665 C GLN B 217 -22.012-14.437-71.4741.00-28^33 B

ATOM 66660 GLNB 217 -21.269-14.712-70.5341.0030,83 JB

ATOM 6667 N LEUB 218 -21.796-14.884-72.702 1.0026.83 B

ATOM 6668 CA LEU B 218 -20.653-15.740-72.9601.0024.72 B

ATOM 6669 CB LEUB 218 -20.897-16.565-74.2301.0028.13 B ATOM 6670 CG LEU B 218 -22.214 -L7.319 -74.453 1.0028.53 B

ATOM 667L CDl LEU B218 -22.191-17.965-75.8261.0028:31 B

ATOM 6672 CD2 LEUB 218 -22.414-18.377-73.390 lJBft-29.24 B

ATOM 6673 C LEUB 218 -19.302-15.029-73.071 1.0022.06 B

ATOM 6674 O LEUB 218 -18.280-15.662-72.8461.0020.21 B ATOM 6675 N GEUB 219 -19.282-13.735-73.403 1.00-19.93 B

ATOM 6676 CA. GLUB 219 -18.001-13.022-73.5621.0018.46 B

ATOM 6677 CB GLUB 219 -18.207-11.518-73.7461.0019.49 B

ATOM 6678 CG GLUB 219 -16.883-10.761-73.843 1.0023.30 B

ATOM 6679 CD GLUB 219 -17.024 -9.332-74.373 1.0029.00 B ATOM 6680 OEl GLU B 219 -18.027 -8.652-74.043 1.0030.52 B

ATOM 6681 OE2 GLUB 219 -16.115 -S.877 -75.111 1M31-Λ0 B

ATOM 6682 C GLUB-2I9 -16.967-13.243-72,468 1.0016.95 B

ATOM 6653 O GLU B 219 -15.77-7 -13.310 -72.734 LOO 14.27 B

ATOM 66-84 N PROSJZ20 -17,409 -13322 -71.209 1.00--18-.05 B A-TQM 668-5- CB PRO B 220 -18.756 -13.023 -70.6871.0017:90^" B^~

ATOM 6686 CA PRQ=B=220 -16.463 -13.546 -70.113^~l7G017.73 B

ATOM -66STCB PRIXB 220 -17.375^"-137655--68.902 1.001-7.18^" B

ATOM 6685 CG PRO B 220 -18.473-12.711-65.243 1.0017.43 B

ATOM 6689 C PROB 220 -15.697-14.842-70.365 1.0017.41 B ATOM 6690 O PROB 220 -14.480-14.897-70.2171.0017773 B

ATOM 6691 N LEU B 221 -16.436-15.884-70.738 1.0016.39 B

ATOM 6692 CA LEU B 221 -15.867-17.194-71.0391.0015.39 B

ATOM 6693 CB LEU B 221 -16.903-18.091-71.7171.0015.95 B

ATOM 6694 CG LEU B 221 -17.746-19.063-70.9001.0014.81 B ^

ATOM 6695 CDl LEUB 221 -16.812-20.045-70.2281.0017.62 B

ATOM 6696 CD2 LEU B 221 -18.589-18.324-69.8821.0015.20 B

ATOM 6697 C LEUB 221 -14.682-17.053-71.973 1.0015.16 B

ATOM 66980 LEUB 221 -13.594-17.545-71.686 LOO 15J77 B ATOM 6699 N TYRB 222 -14.897-16.379-73.0971.0014:56 B

ATOM 6700 CA TYR B^'222 -13.831-16.195-74.065 1.0014.22 B

ATOM 6701 CB TYRB 222 -14.339-15.440-75.3061.0013.46 B

ATOM 6702 CG TYR B 222 -13.325-15.417-76.4221.0013.47 B

ATOM 6703 CDl TYRB 222 -12.894-16.602-77.0141.0014.59 B ATOM 6704 CEl TYRB 222 -1L890 -16.606 -77.971 1.0016.41 B

ATOM 6705 CD2 TYR B 222 -12.729-14.231-76.828 1.0012.82 B

ATOM 6706 CE2 TYRB 222 -11.727-14.224-77.786 1.0014.95 B

ATOM 6707 CZ TYR B 222 -11.311-15.414-78.353 1.0016.92 B

ATOM 6708 OH TYR B 222 -10.327-15.418-79.313 1.0018.74 B ATOM 6709 C TYR B 222 -12.647-15.462-73.448 1.0013.96 B

ATOM 6710 O TYR B 222 -11.525-15.957-73.463 1.0013.57 B

ATOM 6711 N LEUB 223 -12.906-14.291-72.883 1.0014.43 B

ATOM 6712 CA LEU B 223 -11.846-13.499-72.283 1.0016.42 B

ATOM 6713 CB LEU B 223 -12.421-12.279-71.5581.0015.35 B ATOM 6714 CG L-EU B 223 -13.233-11.312-72.415 1.0016.60 B

ATOM 6715 CDl LEU B 223 -13.558-10.085 -71.588 1.0017.31 B

ATOM 6716 CD2 LEUB 223- -12.454 -10.93P-73.6721.0016uS2 B

ATOM 6717 C LEU B 223 -10:975-14.297-71.3221.0017.23 B

ATOM 6718- O EEU B- 223 -9:765 -14.067-71.25:0: 1.0017.39 B- ATOM 67L9: N ASN B 224 -11.576 -l£23*-70.5891.0017.70 B

ATOM 672Qf CA ASN B-224 -10.797 -16.028-69,6-571.0019.46- B

ATOM 6721 CB ASN B 224 -11.687-16.632-68:5671.0019.39 B-

AXOM 6722 CG ASN B 224 -11.872-13.686-67.3791.0022.54 B

ATOM 6723 ODl ASN-B 224 -10.904-15.285-66.7161.0021.26 B ATOM 6724 ND2 ASN B 224 -13.115-15.323-67.1091.0023.94 B

ATOM 6725 C ASN B 224 -9.985-17.105-70.3671.0020.04 B

ATOM 6726 O ASN B 224 -8.826-17.336-70.0101.0021.39 B

ATOM 6727 N LEU B 225 -10.567-17.755-71.3771.0019.22 B

ATOM 6728 CA LEU B 225 -9.828-18.776-72.115 1.0019.05 B ATOM 6729 CB LEU B 225 -10.746-19.538-73.0771.0017.14 B

ATOM 6730 CG LEU B 225 -10.133-20.637-73.961 1.0015.90 B

ATOM 6731 CDl LEU B 225 -9.499-21.709-73.1141.0014.94 B

ATOM 6732 CD2 LEU B 225 -11.212-21.251-74.8391.0015.69 B ATOM 6733. C LEU B 225 -8.733-18.048-72.895 1.0020.51 B

ATOM 6734 O LEU B 225 -7.602-18.528-73.0F61.0021.il B

ATOM 6735 N HIS B 226 -9.052-16.937-73.5221.0020.72 B

ATOM 6736 CA HIS B 226 -8.094-16.065-74.175 1.0022.02 B

ATOM 6737 CB HIS B 226 -8.821-14.889-74.8421.0021.22 B ATOM 6738 CG HIS B 226 -7.942-13.917-75.565 1.0021.61 B

ATOM 6739 CD2 HIS B 226 -7.655-13.791-76.861 1.0021.38 B-

ATOM 6740 NDI HIS BJ226 -7.288 -12.898 -74.9481.0022.44 B

ATOM 6741 CEl HIS B 226 -6.598-12.220-75.8241.0022.02 B

ATOM 6742 NE2 HIS B 226 -6.806 -12.742 -76.993 1.0022.78 B ATOM 6743 C HIS B 226 -6.899-15.618-73.388 1.0022.98 B

ATOM 67440 HIS-B 226 -5.840-15.762-73.834 1.0023.84 B

ATOM 6745 N. ALA B 227 -7.066 -14.978 -7Z2581,0023.29 B

ATOM 6746 CA ALA B 227 -5.927-14.575-71.4441.0022.27 B

ATOM 6747 GB ALA B 227 -6.400-13.874-70.2101.0022.66 B ATOM 6748 C ALA B 227 -5.U2 -15.797-71.0591.0022.27 B

ATOM 6749 O ALA B 227 -3.874-15.760-71.0841.0021.04 B

ATOM 6750 N. PHE B 228 -5.812-16.880-70.712 1.00.22.63 B

ATOM 6751 CA PHE B 228- -5.155 -18J.15 -70306 L00.22.45 B

ATOM 67-52_CB-PHE B 228 -6.163-19,185-69.923 Lt)O 22.79 B ATOM 6753 CG PHE B 228 -5.520_=20.4§4-69.41θ- 1.0.0:24.39 B

ATOM 675Φ CDl PHE B-228 -4.843-20.461 -68.B41.0033.41 B

ATOM 6755- CD2 PHEB 228 -5.576 -21:643 -70.157 Ii)JO 25.34 B^"

ATOM 6756 CEl PHE B 228 -4.234-21.624-67.731 1.0023.3-0. B

ATOM 6757 CE2PHEB228 -4.967-22.816-69.701 1.0022.88 B ATOM 6758 CZ PHE B 228 -4.296-22.807-68.4891.0022.61 B

ATOM 6759 C PHE B 228 -4.253-18.678-71.3771.0022.02 B

ATOM 6760 O PHE B 228 -3.134-19.079-71.0921.0021.51 B

ATOM 6761 N VAL B 229 -4.743-18.724-72.6091.0022.59 B

ATOM 6762 CA VAL B 229 -3.947-19.235-73.7221.0022.91 B ATOM 6763 CB VAL B 229 -4.822-19.470-74.9741.0023.63 B

ATOM 6764 CGl VAL B 229 -3.966-19.920-76.140 1.0021.53 B

ATOM 6765 CG2VALB229 -5.884-20.525-74.659 1.0026.20 B

ATOM 6766 C VAL B 229 -2.809-18.283-74.089 1.0022.16 B ATOM 6767 O VAL B 229 -1.693 -18.737 -74.369- 1.0021.4.8 B

ATOM 6768 N ARG B 230 -3.083 -16τ973 -74.083 1.0021.06 B

ATOM 6769 CA ARG B 230 -2.071-15.983-74.432 1.0020.67 B

ATOM 6770 CB ARG B 230 -2.615-14.571-74.251 1.0020.76 B

ATOM 6771 CG ARG B 230 -1.617-13.464-74.593 1.0022.09 B ATOM 6772 CD ARG B 230 -2.286-12.098-74.5541.0023.42 B

ATOM 6773 NE ARG B 230 -2.971-11.878-73.2821.0026.06 B

ATOM 6774 CZ ARG B 230 -3.820-10.886-73.03.61.0025.34 B

ATOM 6775 NHl ARG B 230 -4.110-10.000-73.9671.0024.93 B

ATOM 6776 NH2ARGB230 -4.383 -1Q.788 -71.8481.0027.59 B ATOM 6777 C ARGB 230 -0.844-16.192-73.5591.0020.86 B

ATOM 6778 O AJRG B 230 0.278-16.299-74.0661.0020.03 B

ATOM 6779 N ARG B 231 -1.066-16.268-72.2481.0021.67 B

ATOM 6780 CA ARGB 231 0.019 -16.4S4 -71.2941.0021.51 B

ATOM 67Sl CB ARG B 231 -0.553 -16τ672 -69.881 1.002139 B ATOM 6782 CG ARG B 231 0.450-17.225-68.8701.0021.72 B

ATOM -6783 CD ARG B 231 1.579-16.250-68.5871.0022.79 B

ATOM 6784 NE ARGB231 1.388 -15.571 -67.310 1.0025:85 B

ATOM 6785 CZ ARGB 231 2-.318 -15,489 -66.3601.0028.16 B- ATOIvL 6786 NH1ARGΕL231 2.051- -L4r859 -65,2291.0028.48 B ATOM 6787 NH2 ARGB 231 3.519-16.031-66.535 1.0027.57 B

ATOM 678ST C. ARG B 231 -0.825 -17:720 -7L709- -1.0021.35- ^"B:

ATOM 6789 O ARGB 231 2:044-17.774-71.542 1.0021.43 B

ATOM 6790 N ALA B 232 0.136 -18.715 -72.2541.0.0,20.76 B-

ATOM 6791 CA ALA B 232 0.802 -19.932--72.6901.0020.23 B ATOM 6792 CB ALA B 232 -0.218 -21.023 -72.9741.0020.20 B

ATOM 6793 C ALA B 232 1.622-19.647-73.9391.0020.04 B

ATOM 6794 O ALA B 232 2.760-20.103-74.056 1.0019.26 B

ATOM 6795 N LEU B 233 1.054-18.892-74.873 1.0019.63 B

ATOM 6796 CA LEU B 233 1.786-18.582-76.090 1.0021.10 B ATOM 6797 CB LEU B 233 0.873-17.874-77.0971.0021.92 B

ATOM 6798 CG LEU B 233 -0.255-18.721-77.7101.0021.31 B

ATOM 6799 CDl LEU B 233 -1.187-17.842-78.5241.0020.30 B

ATOM 6800 CD2LEUB233 0.339-19.820-78.5671.0019.80 B

ATOM 6801 C LEU B 233 3.004 -17.725 -75.7504.0022.39 .B

ATΘM 6802 O LEU B 233 4.049-17.849-76.3861.0021.88 B

ATOM 6803 N HIS B 234 2.869-16.868-74.738 1.0024.08 B

ATOM 6804 CA HIS B 234 3.973-16.005-74.2991.0025.31 B

A⁵FOM 6805 CB HIS-B 234 3.502-15.044-73.1861.0026.17 B

ATOM 6806 CG HISΕ 234 4.584-14.156-72.633 1.0028.56 B

ATOM 6807 CD2HIS-B 234 4.84» -12.840 -72.8321.0028.59 B

ATOM 6808 NDl HfS B 234 5.565 -14.61-4-71.7781.0030.42 B

ATOM 6809 CEl HIS B 234 6.387-13.623-71.4771.0030.15 B

ATOM 6810 NE2 HIS B 234 5.975-12.536-72.104 LOO 28.10 B

ATOM 68-11 C HIS B 234 5.117-16.877-73,7861.0026.21 B

ATOM 6812 O HIS B 234 6.287-16.646-74.093 1.0025.87 B

ATOM 6813 N ARG B 235 4.767-17.890-73.011 1.0027.16 B

ATOM 6814 CA ARG B 235 5.754-18.793-72.4561.0029,03 B

ATOM 6815 CB ARG B 235 5.043-19.828-71.5861.0030.09 B

ATOM 6816 CG ARG B 235 J5.832 -20.326 -70.3901.0032.57 B

ATOM 6847 CD ARG B 235 5.022-20.114-69.1021.0034.97 B

ATOM 6818^{" "}TsIE ARG B 235 3.617 -2θτ512 -69..243 1.0036.36 B

ATOM 6819 CZ ARGB-235 2.685 -20366-68.2961.0036.83 B

ATOM 6820 NHl ARG B 235 -2-990 -19.825 -67. Ill 1.0015.93 JBr - ATOM 6821- NH2 ARGJB 235 1.435-20.761-68.535 1.0035.62 B

ATOM 6822-C ARGB-235 6.560-19.477 -73.5771.0030.15 B

-ATOM 6823^" O ARG B 235 7:784 -19.603 -73τ4791.0030:63 -B

ATOM 6824 N ARGB 236 5.909-19.906-74.6381,0031.31 B

ATOM 6825 CA ARG B 236 6.548-20.536-75.8071.0031.43 B

ATOM 6826 CB ARG B 236 5.609-21.521-76.4451.0031.09 B

ATOM 6827 CG ARG B 236 5.661-21.683-77.8681.0031.43 B

ATOM 6828 CD ARG B 236 6.548 -22.761 -78.3361.0032.54 B

ATOM 6829 NE ARG B 236 6.061-24.073-78.041 1.0034.07 B

ATOM 6830 CZ ARG B 236 6.575-25.162-78.513 1.0032.33 B ATOM 6831 NHl ARG B 236 7.577-25.076-79.3121.0029.15 B

ATOM 6832 NH2 ARG B 236 6.081-26.325-78.1851.0031.45 B

ATOM 6833 C ARGB 236 7.205-19.678-76.8371.0031.48 B

ATOM 6834 O ARG B 236 8.304-19.946-77.2061.0031.93 B

ATOM 6835 N- TYR-B 237 6.562-18.613-77.264 1.0030.56 B

ATOM 6836 CA TYR B 237 7.156-17:754-78.284 1.0029.73 B

ATOM 6837 CB TYRB 237 6.081-17.226-79.240 1.0028.59 B

ATOM 68-38 CG TYR B 237 5.357-18.320-79.9871.0028.00 B

ATOM 6839 CDl TYR B 237 4.018-18.593-79.7291.0029.08 B

ATOM 6840 CEl TYRB 237 3.350-19.613-80.3971.003L20 B

ATOM 6841 CD2TYRB237 6.017-19.096-80.9341.0028.30 B

ATOM 6842 CE2 TYRB 237 5.364 -20.126 --81.6141.0029.20 B

ATOM 6843 CZ TYRB 237 4.028-20.380-81.3421.0030.81 B

ATOM 6844 OH TYRB 237 3.366-21.392-82.010 1.0030.34 B

ATOM 6845 C TYR B 237 7.983-16.597-77.750 1.0029.62 B

ATOM 6846 O TYR B 237 8.791-16.032-78.4741.002S.77 B

ATOM 6847 N GLY B 238 7.781-16.231-76.493 1.0030.50 B

ATOM 6848 CA GLY B 238 8.573-15.146-75.9361.0030.96 B

ATOM 6849 C GLY B 238 8.024-13.734-75.985 1.0030.45 B

ATOM 6850 O GLYB 238 7.215-13.376-76.831 1.0030:03 B

ATOM 6851 N ASP B 235 8.508-12.922-75.0591.0032.37 B

ATOM 6852 CA ASFΕT239 8.089-11.535-74.923 1.0034,39 B

ATΘM- 6853 CB ASP-B 23i> 8.952 -10.856--73.8571.0035.83 B

ATOM 6854- GG ASE-B-239 8.254 -9.669-73.232 H)GJSiU B

ATOM 6855 ODl-ASP B-239 7.146 -9:875-72.6921.0039.77 B

ATOM 6856 OD2ASPB239 8.793 -8.540 -73.2SO- 1.00-39.71 ^"B

ATOM 6857 C ASP-B 239 8.119-10.687-76.2071.0033:63 B

ATOM 6858 O ASP B 239 7:479 -9.639 -76r2781.0032.08 B

ATOM 6859 N ARG B 240 8.732-11.181-77.251 1.0033.23 B

ATOM 6860 CA ARG B 240 8.861 -Ϊ0.442 -78.459 1.0032.47 B

ATOM 6861 CB ARG B 240 9.966-10.987-79.262 1.0034.01 B

ATOM 6862 CG ARG B 240 10.199-10.122-80.379 1.0038.24 B

ATOM 6863 CD ARG B 240 11.533-10.254-80.957 1.0041.40 B

ATOM 6864 NE ARG B 240 11.984 -9.061-81.6301.0042.59 B ATOM 6865 CZ ARG B 240 12.127 -8.991-82.9201.0044.09 B

ATOM 6866 NHl ARG B 240 11.851-10.033-83.6551.0043.55 B

ATOM 6867 NH2ARGB240 12.536 -7.880-83.483 1.0043.90 B

ATOM 6868 C ARG B 240 7.696-10.513-79.3221.0031.55 B ATOM 6869 O ARG B 240 7.355 -9.577-79.9371.00^30.43 B

ATOM 6870 N TYRB 241 7.118-11.678-79.405 1.0030.27 B

ATOM 6871 CA TYRB 241 5.972-11.905-80.2761.0028.18 B

ATOM 6872 CB TYR B 241 6.199-13.167-81.1001.0029.74 B

ATOM 6873 CG TYRB 241 7.397-13.079-81.991 1.00-31.4S B ATOM 6874 CDl TYRB 241 8.491-13.897-81.7821.0032.92 B

ATOM 68-75 CEl TYRB 241 9.621-13.807-82.588 1.0036.73 B

ATOM^" 6876 CD2 TYR B 241 7.452-1-2.153-83.0361.0033.91 B

ATOM 6877 CE2 TYRB 241 8.581-12.046-83.8491.0035.38 B

ATOM 6878 CZ TYRB 241 9.662 -12.882 -83.6181.0036.91 B ATOM 6879 OH TYR B 241 10.785-12.821-84.4081.0038.75 B

ATOM 6880 C TYRB 241 4.600-11.987-79.631 1.0027.03 B

ATOM 6881 O TYR B 241 3.590-12.088-80.325 1.0027.79 B

ATOM 6882 N ILE B 242 4.543-11.973-78.3121.0025.27 B

ATOM 6883 CA ILE B 242 3.253-12.021-77.651 1.0023.95- B ATOM 6884 CB ILE B 242 3.076-13.334-76.855 1.0022.69 B

ATOM 6885 CG2 ILE-B 242 1.748-13.329-76.131 LDO-22747 B

ATOM 6886 CGl JLE B 242 3.130 -14.539-77:794- 1.0021.86 B

ATOM 688-7 CDl ILE B 242 1,899 -14.702 -78τ661 1.0022.55 B

ATOM 6888 C TLEΕTΑ2 3.179-10,845-76^".6961.0023.43 B A-TOM 6889 O ELE B 242 4.153-10.537-767021 1.0024.17 B-

ATΘM. -6890 N ASN B 243^" 2.049M0.153 -76.663 1.0023.08 B-

ATOM 6891 CA ASNB 243 17919 -9.042 -75.727 J.0022.44 Ε-

ATOM 6892 CB ASN B 243 1.521 -7.742-76.4241.0022.04 B

ATOM 6893 CG ASN B 243 L353 -6.594-75.449 1.0022.02 B- ATOM 6894 ODl ASN B 243 0.648 -6.713-74.4461.0022.51 B

ATOM 6895 ND2ASNB243 2.002 -5.475-75.7361.0022.16 B

ATOM 6896 C ASN B 243 0.845 -9.430-74.7291.0022.08 B

ATOM 6897 O ASN B 243 -0.326 -9.611-75.0981.0022.03 B

ATOM 6898 N LEU B 244 1.257 -9.561 -73.4691.0021.01 B ATOM 6899 CA LEU B 244 0.358 -9.960 -72.392 1.0020.38 B

ATOM 6900 CB LEU B 244 1.155 -10.181 -71.108 1.00 18.30 B

ATOM 6901 CG LEU B 244 2.049 -11.417 -71.181 1.00 16.14 B

ATOM 6902 CDl LEU B 244 3.085 -11.4 LO -70.076 1.00 16.27 B

5 ATOM , 6903 CD2 LEU B 244 1.160-12.643 -71.106 LOT⁾ 15.25 B-

ATOM 6904 C LEU B 244 -0.771 -8:987 -72.157 1.0020.70 B-

ATOM 6905 O LEU B 244 -1.719 -9.291 -71.440 1.0020.34 B

ATOM 6906 N ARG B 245 -0.680 -7.874 -72.794 1.0022.95 B

ATOM 6907 CA ARG B-245^' -1.689 -6.898 -72.663 1.00 26.00 B

10 ATOM 6908 CB ARG B 245 -1.100 -5.743 -71.973 1.00 27.86 B

ATOM 6909 CG ARG B 245 -1.544- -5.539 -70.588 1.00 31.18 B

ATOM 6910 CD ARG B 245 -0.481 -5.572_-69.604 1.00_35.24 B

ATOM 6911 NE ARG B 245 0.623 -4.739 -69.975 1.0040.23 B

ATOM 6912 CZ ARG B 245 0.963 -3.664 -69.337 1.0042.55 B

L5 ATOM 6913 NHl ARG B 245 0.271 -3-299 -68.303 LOO 44.34 B-

ATOM 6914 NH2 ARG B 245 1.994 -2.956 -69.707 LOO 43.15 B

ATOM 6915 C ARG B 245 -2.208 -6.460 -73.964 1.00 26.90 B

ATOM 6916 O ARG B 245 -3.005 -5.651 -73.999 1.0027.65 B

ATOM 6917 N GLY B 246 -1.789 -7.070 -75.049 1.0027.24 B

20 ATOM 6918 CA GLY B 246 -2.246 -6,766 -76.394 1.0025.95 B

ATOM 6919 C GLY & 246 -2.988 -7.944 -76.979 1.00 24.24 B

ATOM 6920. O GLY B 246 -3.1-37 -8.949 -76.298 1.0024,92 B

ATOM 6921 N PROrB 247 -3.477 -7.854 -78.227 LDO 22.68- B

ATOM 6922^" CD PRO-B 247 -3.-479 -6τ6?&-79.1T9 1.0021.66 B

_2i A=TOM -6923 JCA PRΘ-B-24-7 -4.201 -8.971 -78-843 1.0020.46 B

ATOM 6924 CB. PRO B 247 -4^923 -8.3-13 -80,010 1.00 19.56 B-

ATOM 6925 CG PRO-B^~T4.7 -3.962 -7.269-80.432 1.-0021.20 B

ATOM 6926 C PRO B 247 -3.234 -10.050 -79.286 1.00 1937 B

ATOM 6927 O PRO B 247 -2.023 -9.841 -79.316 1.00 18.26.. β-

30 ATOM 6928 N ILE B 248 -3J765 -11.212 -79.625 1.00 19.87 B

ATOM 6929 CA ILE B 248 -2.909 -12.310 -80.057 1.00 19.37 B

ATOM 6930 CB ILE B 248 -3.523 -13.678 -79.672 1.00 17.70 B

ATOM 6931 CG2 DLE B 248 -2.547 -14.788 -79.979 1.00 17.20 B

ATOM 6932 CGl ILE B 248 -3.874 -13.702 -78.191 1.00 18.35 B _29Q

ATOM 6933 CDl ILE B 248 -4.509-14.999-77.7491.0017.39 B

ATOM 6934 C ELE B 248 -2.675-12.323-81.5651.0018.82 B

ATOM 6935 O DLE B 248 -3.570-12.005-82.342 LOO 19.02 B

ATOM 6936 N PRO B 249 -1.456-12.674-81.9971.0019.42 B

5. ATOM 6937 CD PRO B 249 -0.233-12.765 -8-1.1821.0020.56 B

ATOM 6938 CA PRO B 249 -1.131-12.740-83.4261.0020.44 B

ATOM 6939 CB PRO B 249 0.334-13.145-83.420 1.0021.40 B

ATOM 6940 CG PRO B 249 0.847-12.464-82.183 1.0021.16 B

ATOM 6941 C PRO B 249 -2.023-13.822-84.043 1.0020.41 B 0 ATOM 6942 O PRO B 249 -1.970-14.976-83.626 1.0020.15 B

ATOM -6943 N ALA B 250 -2.824-13.443-85.0361.0020.31 B

ATOM .6944 CA ALA B 250 -3.780 -14.346 -S5.696 l.θθ 19.16 B

ATOM 6945 CB ALA B 250 -4.484-13.596-86.825 1.0018.60 B

ATOM 6946 C ALA B 250 -3.319-15.710-86.2141.0018.37 B 5 ATOM 69470 ALAB250 -4.155-16.536-86.5601.0019.30 B

ATOM 6948 N HISB 251 -2.022-15.971-86.255 1.0017.4X) B

ATOM 6949 CA fflS B 251 -1.555-17.248-86.7691.0018.91 B

ATOM 6950 CB IDS B 251 -0.506 -16.986-87.835 LQO 18.35 B

ATOM 6951 CG HIS B 251 0.744-16.371-87.2981.0018.22 B 0 ATOM 6952 CD2 HIS B 251 2.026-16.805-87.300 1.0018.71 B

ATOM 6953 NDl HtS B 251 07751-15.169-86.635 1.0019.23 B

ATOM 6954 CEIiCS B 251 1.982-14.837-86.248 l.OO-19.78 B

ATOM 695-5- NE2 HIS ^"B-251 2.776--15_.864-86i6401,0018.50 B

-ATOM^" 6956 C HIS B 251 -0.961-18213-85.74I 1,0020.26- B 5 ATOM 6957 O HIS_B_251 -0.272 -19: L67 -86.1-13 1.90:22.64- B

AIOM -6958 TST LEUB-252 -1.218 -1779-89 -84.458 1.0021Jt4- B

ATOM -6959 CA LEU B 252 -0.642 -18.847 -S3.429^" 1.0ΘT9.87 B

ATOM 6960 CB LEU-B 252 0.027-17.991-82.3691.0020.54 B

ATOM 6961 CG LEU B 252 1.005-16.997-82.981 1.0021.73 B 0 ATOM 6962 CDl LEU B 252 1.535-16.075-81.9041.0024.85 B

ATOM 6963 CD2 LEU B 252 2.137-17.751-83.6561.0021.93 B

ATOM 6964 C LEU B 252 -1.616-19.775-82.763 1.0018.66 B

ATOM 6965 O LEU B 252 -1.207-20.667-82.035 1.0017.04 B

ATOM 6966 N LEU B 253 -2.903-19.578-83.013 1.0019.25 B _m

ATOM 6967 CA LEU B 253 -3.916-20.414-82.3941.0019.58 B

ATOM 6968 CB LEU B 253 -5.223-19.635-82.255 1.0020.54 B

ATOM. 6969 CG LEUB 253 -5.249-18.512-81.2041.0020.58 B

ATOM 6970 CDl LEU B 253 -4.605-18.997-79.925 1.0020.51 B ATOM 6971 CD2LEUB253 -4.502-17.310-81.703 1.0021.84 B

ATOM 6972 C LEU B 253 -4.170-21.745-83.0901.0020.2T) B

ATOM 6973 O LEU B 253 -5.237-22.334-82.948 1.0020.57 B

ATOM 6974 N GLYB 254 -3.181-22.219-83.839 1.0021.11 B

ATOM 6975 CA GLY B 254 -3.299-23.500-84.516 1.0022.14 B ATOM 6976 C GLY B 254 -4.409-23.686-85.5401.0023.50 B

ATOM 6977 O GLY B 254 -4.887-24:806-85.7361.0024.00 B

ATOM 697S- N ASP B 255 -4.812 -22.601- -86.1971.0023.64 B

ATOM 6979 CA ASP B 255 -5.855 -22.641 -87.213 1.0023.22 B

ATOM 69.8.0 CB ASP B-255 -7.240-22.710-86.5741.0024.00 B ATOM 6981 CG ASP B 255 -8.365-22.596-87.60.0 1.0027.63 B

ATOM 6982 ODl ASP B 255 -8.363 -21.614 -88.3761.0028.48 B

ATOM 6983 OD2ASPB255 -9.258-23.475-87.6391.00.28.83 B

ATOM 6984 C ASP B-255 -5.748 -21.381 -88.054 1.0023.59 B

ATOM 6985 O ASP B 255 -5.600 -20.287 -87.5 T8 1.0024.69 B ATOM 6986 N MET B 256 -5.833 -21.551 -89.3721.0023.63 B

ATOM 6987 CA MET B 256. -5.737-20.449 -90..3361.0022.67 B

ATOM -6988 CB METJS256 -6.225 -20.929^-91.715 1.0021.60 B

AlOM 6989 CG MET B-256 -6.044 -19.938 -92.855 1.0018793 R

AT-ΘM 69.90 SD METJE£256 -4.338 -19.351 -93.031 ITOO 20-97 B ATOM 6991 CE MET B 256 -3.478 -20.835-93-442 kθO 18.41- B

ATOM 6992 C MET B 256 -6.5-13 -19^03 -89.9271.0022.4.7 B^"

ATOM 6993-0 MET-B 25.6- -6:025 -18.079 -90.0661.0020.92 B

ATOM 6994 N TRP B 257 -7.715 -19.417 -89.4G.61.0023.06 B

ATOM 6995 CA TRP B 257 -8.590-18.330-88.9961,0024.82 B ATOM 6996 CB TRP B 257 -9.978-18.598-89.5571.0025.20 B

ATOM 6997 CG TRP B 257 -9.947-18.801-91.0241.0027.53 B

ATOM 6998 CD2 TRP B 257 -9.763-20.043-91.7101.0029.46 B

ATOM 6999 CE2 TRP B 257 -9.760-19.760-93.0941.0029.76 B

ATOM 7000 CE3 TRP B 257 -9.602 -21.370 -91.293 1.0030.37 B ATOM 7001 CDl TRP B 257 -10.040-17.839-91.9901.0028.93 B

ATOM 7002 NEl TRP B 257 -9.928-18.407-93.2371.0029.83 B

ATOM 7003 CZ2 TRP B 257 -9.601 -20759 -94.0591.0029.66 B

ATOM 7004 CZ3 TRP B 257 -9.443-22.360-92.2551.0028.48 B ATOM 7005 CH2 TRP B 257 -9.445 -22.047 -93_£ 181.0028.72 B

ATOM 7006 C TRP B 257 -8.679-18.086-87.489 LOO 24.55 B

ATOM 7007 O TRP B 257 -9.361-17.159-87.0501.0024.08 B

ATOM 7008 N ALA B 258 -7.984-18.909-86.711 1.0024.08 B

ATOM 7009 CA ALA B 258 -8.008-18.795-85.2601.0023.69 B ATOM 7010 CB ALA B 258 -7.474-17.437-84.8421.0022.34 B

ATOM 7011 C ALA B 258 -9.442-18.971-84.765 1.0023.31 B

ATOM 7012 Θ ALA B 258 -9.874-18.252-83.8541.0023.14 B

ATOM 7013 N GLNB 259 -10.176-19.901-85.3571.0023.73 B

ATOM 7014 CA GLN B 259 -11.565-20.088-84.9751.0025.42 B ATOM 7015 CB GLN B 259 -12.433-20220-862341.0027.91 B

ATOM 7016 CG GLN B 259 -12.263-21.499-87.0381.0030.22 B

ATOM 7017 CD GLN B 259 -12.819 -21.349 -«8.4441.0033.44 B

ATOM 7018 OEl GLN B 259 -12.125-20.865-89.343 1.0036.51 B

ATOM 7019 NE2 GLNB 259 -14.080-21.741-88.639 1.0032.96 B ATOM 7020 C GLN B 259 -11.826-21.245-84.0171.0025.57 B

ATOM 7021 O GLN B 259 -12.933-21.390-8374841.0025.13^" B

ATOM 7022 N SER B 260 -10.809-22.077-83.823 1.0025.46 B

ATOM 7023 CA SERB 260 -10.882-23.197-82.8941.0027.10 B

ATOM 7024 CB-SER B 260 -11-.5Q3 -24.433 -83549- 1.0024-.95 B ATOM 7025 OG SER B 260 -10.688 -24^'.928 -84.5841.00.28.64 B

ATOM 7026 C SER^~B 265- -9.426-23.430-82.4941.00-28.21 B

ATOM 7027 O SER B 260 -8.534 -23.470 -83.342 LOO 28.47 B

ATΘM 7028 N TRPB 261 -9.183-23.558-81.195 1.0029.86 B

ATOM 7029 CA TRPB 261 -7.824-23.717-80.6961.0031.13 B ATOM 7030 CB TRP B 261 -7.579-22.673-79.5961.0030.79 B

ATOM 7031 CG TRP B 261 -7.980-21.251-79.985 1.0029.47 B

ATOM 7032 CD2 TRP B 261 -7.965 -20.097 -791371.0028.29 B

ATOM 7033 CE2 TRP B 261 -8.357-18.993-79.925 1.0027.16 B

ATOM 7034 CE3 TRP B 261 -7.657-19.889-77.7871.0027.38 B ATOM 7035 CDl TRP B 261 -8.373-20.806-81.2201.0028.11 B ATOM 7036 NEl TRP B 261 -8.600-19.454-81.1901.0026.68 B ATOM 7037 CZ2 TRP B 261 -8.448-17.703-79.4101.0026.96 B ATOM 7038 CZ3 TRP B 261 -7.748-18.611-77.2761.0027.41 B ATOM^' 7039-GHGTRPB^l -8.142-17.530-78.088 1.0027.30 B ATOM 7040 C TRPB 261 -7.397-25.097-80.1821.0031.99 B ATOM 7041 O TRP B 261 -6.308-25.224-79.6161.0031.88 B ATOM 7042 N GLUB 262 -8.223-26.126-80.381 1.0032.78 B ATOM 7043- CA GLU B 262 -7.873-27.457-79.893 1.0034.30 B ATOM 7044 CB GLU B 262 -8.999-28.464-80.153 1.0036.35 B ATOM 7045- CG GLUB-262^" -9.251-28.8-15-81.5991.00:42.20 B ATOM 7046 CD-GLUB 262^" -9.882-27:674-8-2.365 1.0047.50 B ATOM 7047 OEl GLUB 262 -9.177-26.664-82.6001.0050.53 B ATOM 7Q48-OE2GLUB262 -11.083-27.783-82.7271.0049.30 B ATOM- 7049 C GEU-B 262 -6.564-28.002-80.4521.00-33.85 B ATOM 7050 O GLU B 262 -5.992-28.937-79.891 1.Q034.16 B ATOM 7051 N ASN B 263 -6.083-27.415-81.543 1.0033.98 B ATOM 7052 CA ASN B 263 -4.831-27.857-82.1501.0034.54 B ATOM 7053 CB ASN B 263 -4.761-27.441-83,6221.0035.87 B ATOM 7054 CG ASN B 263 -5.538-28.367-84.521 1.0037.79 B ATOM 7055. GDTASN-B 263 -5.178-29.528,-84.692 1.0039.16 B ATOM 7056- ND2 ASN3-J263 -6.62Q -27.862 -85.098 1.0040.36 B ATOM 705.7 C ASN B 263 -3.59S- -27.341 -81.425 1.0© 34.03 B ATGM-7058 O ASN B 263 -2.479 -27-603 -81.8441.0033.21 B ATOM- 7059 N ILEB26-4 -3.819-26.794-80.308 1.0034.70 B AXOM 7060 CA ILE B-264 -2.743^~-26.212 -79:6591:0036.56 Br ATOM- 70.61 CB ILE B 264 -2.894 -24-861 -79.912 1.00-37.19 B ATOM 7062 CG2 ILEJB 264 -2.985 -24.163 -78.7571.0038.17 B ATOM 7063 CGl ILE B 264 -1.753-24.379-80.653 1.0037.64 B ATOM 7064 CDl BLE B 264 -1.432-23.227-80.1671.0.039.01 B ATOM 7065 C DLE B 264 -2.918-26.562-78.2301.0036.94 B ATOM 7066 O ILE B 264 -2.483-25.932-77.3771.0036.97 B ATOM 7067 N TYR B 265 -3.609-27.653-78.041 1.0037.21 B ATOM 7068 CA TYR B 265 -3.930-28.245-76.7571.0036.40 B ATOM 7069 CB TYRB 265 -4.763-29.512-76.9801.0036.14 B

ATOM 7070 CG TYR B 265 -5.110-30.246-75.711 1.0037.26 B

ATOM 7071 CDl TYRB 265 -6.010-29.703-74.788 1.0037.55 B

ATOM 7072 CEl TYR B 265 -6.281-30.355-73.575 1.0037.58 B ATOM 7073 CD2TYRB-265- -4.491 -31.462 -75.3971.0037.08 B

ATOM 7074 CE2 TYR-B 265 -4.750-32.117-74.1931.0037.28 B

ATOM 7075 CZ TYR B 265 -5.643-31.559-73.289 1.0036.96 B

ATOM 7076 OH TYR B 265 -5.890-32.203-72.1071.0036.45 B

ATOM 7077 C TYR. B 265 -2.643 -28.576 -7&.001 1.003626 B ATOM 7078 O TYR B 265 -2.509 -28.259 -74.818 10036.16 B

ATOM 7079 N ASP B 266 -1.689-29:188-76.6941.0035.99 B

ATOM 7080 CA ASP B^266 -0.420-29.567-76.0781.0037.23 B

ATOM 7081 CB ASP B 266 0.428-30.394-77.0591.0039.84 B

ATOM 7082 CG ASP B 266 -0841 -29.604 -78.301 1.0043.75 B ATOM 7083 ODl ASP B 266 -0.063-29.178-79.056 1.0046.15 B

ATOM 7084 OD2 ASP B 266 2.065-29.408-78.529 1.0043.83 B

ATOM 7085 C ASP B 266 0.417-28.400-75.535 1.0036.31 B

ATOM 7086 O ASP B 266 1.518-28.609-75.023 1.0036.63 B

ATOM 7087 N MET B 267 -0.090-27.177-75.6371.0035.12 B ATOM 7088 CA MET B 267 0.647-26.028-75.1301.0034.41 B

ATOM 7089 CB METB-267 0.855 -24.979^~-76r2101.0034.18- B

ATOM 7090 CG MET B 267 1.494-25.484-77.4661.0036.61 B

ATOM 7051 SD MET B 267 1.928-24.091-78.523 UOO 37.28 B -ATOM^""7092 CE MET B 267 .3.725 -24.245 -78.528 1.0034.54 B ATOM 7093 C MET B 267 -0.10S--25.370 -73.995-1.0034.79 B

ATOM 7094 O MET B 267 0.429-24.498-73.320-1.0036.35 B

ATOM 7095-N VAL B 268 4.3561=25.774-73.8001.0033.26 B

ATOM 7096 CA VAL B 268 -2.162-25.178-72.755 l.OQ-32.39 B

ATOM 7097 CB VAL B 238 -3.324-24387-73.36-5 1.0031.12 B ATOM 7098 CGl VAL B 268 -2.781-23.229-74.165 1.0029.64 B

ATOM 7099 CG2 VAL B 268 -4.161-25.285-74.2371.0029.68 B

ATOM 7100 C VAL B 268 -2.711-26.186-71.7571.0033.71 B

ATOM 7101 O VAL B 268 -3.064-25.831-70.632 1.0033.28 B

ATOM 7102 N VAL B 269 -2.773-27.446-72.171 1.0035.08 B ATOM 7103 CA VAL B 269 -3.287-28.495-71.3001.0035.68 B

ATOM 7104 CB VAL B 269 -2.841-29.913-71.781 1.0035.61 B

ATOM 7105 CGl VAL B 269 -1.334-29.978-71.9421.0035.03 B

ATOM 7106 CG2VALB269 -3.307-30.963-70.791 1.0035.51 B

ATOM 7107 C VAL B 269 -2.821-28.260-69.871 L00~35.58 B

ATOM 7108 O VAL B 269 -1.629-28.294-69.5781.0034.66 B

ATOM 7109 N PRO B 270 -3.773-27.985-68.968 1.0036.56 B

ATOM 7110 CD PRO B 270 -5.199-27.827-69:3041.0036.13 B

ATOM 71 π CA PRO B 270 -3.551-27.727-67.5441.0038v85 -B

ATOM 7112 CB PRO B 270 -4.960-27.764-66.9741.0037.80 B

ATOM 7113 CG PRΘ B 270 -5.750-27.135-68.0781:0037.04 B

ATOM 7114 G PRO B 270 -2.624 -28J-27 -66.8641.0041.69 B

ATOM 7115 O PRO B 270 -1.534-28.365-66.4191.0042.89 B

ATOM 7116 N PHE B 271 -3.051-29.984-66.787 LOG 44.18 B-

ATOM 7117 CA PHE B 271 -2.245 -31.016 -66.144- 1.0045.80 B

ATOM 71-18 CB PHE B 271 -3.070-31.708-65.0701.0044.56 B

ATOM 7119 CG PHE B 271 -3.789-30.750-64.1801.0043.49 B

ATOM 7120- CM PHE B 271 -5.166-30.617-64.2491.0043.20 B

ATOM 7121 CD2 PHE B 271 -3.089-29.949-63.2981.0042.12 B

ATOM 7122 CEl PHE B 271 -5.831-29.700-63.4521.0041.69 B

ATOM 7123 CE2 PHE B 271 -3,-748 -29.037 -62.5071.0041.07 B

ATOM 7124 CL PHE B 271 -5.123 -28.913 -62.583 1.00-40.95 B

ATOM 7125 C PHE-B 271 -1.734 --32.018-67.156 1.00-4^68 JB.

ATOM- 7126 O EHE B 271 -2.413 -32.993 -67.487, LOO 47lδβ B

ATOM- 712.7- ^"N PRO B 272 -0.517-3L781-67..662 t.00^49.60- B

ATOM 7128 CD PSOB 272 0.295-30.616-672801JQΩ-49.61 B

ATOM 7T29 CA PRO B 272 0.196--32.591 -68.651 1.0052.19 B-

ATOM 7130 CB PRO B 272 1.525-31.853-68.8121.0051.23- B

ATOM 7131 CG PRO B 272 1.175 -30.450 -68.4881.0050.69 B

ATOM 7132 C PRO B 272 0.403-34.026-68.191 1.0054.54 B

ATOM 7133 O PRO B 272 0.378-34.957-69.0051.0054.80 B

ATOM 7134 N ASP B 273 0.608-34.180-66.8821.0056.81 B

ATOM 7135 CA ASP B 273 0.844-35.477-66.2521.0059.57 B

ATOM 7136 CB ASP B 273 0.689-35.351-64.7301.0060.95 B ATOM 7137 CG ASP B 273 1.456-36.427-63.970 1.0062.77 B

ATOM 7138 ODl ASP B 273 2.706-36.445-64.0661.0064.05 B

ATOM 7139 OD2 ASP B 273 0.812-37.253-63.2801.0063.57 B

ATOM 7140 C ASP B 273 -0.116-36.538-66,791 l.OJO 61.06 B

ATOM 7141 O ASP B 273 0.317-37.539-67.3801.0061.20 B

ATOM 7142 N LYS B 274 -1.411-36.318-66.5891.0062.13 B^~

ATOM 7143 CA LYS B 274 -2.435-37.140-67.2241.0062.87 B

ATOM 7144 CB LYS B 274 -3.831-36.674-66.8041.0061.63 B

ATOM 7145 CG XYS B 274 -3.965-3^.375-65.3201.0059.72 B

ATOM 7146 CD LYS B 274 -5.258 -36.943 -64.7570.0060.12 B

ATOM 7147 CE LYS B 274 -5M5 -38.384 -65.1940.0060.29 B

ATOM 7148 NZ LYS B 274 -6.546-38.506-66.211 0.0059.93 B

ATOM 7149 C LYS B 274 -2.306-37.105-68.743 1.0064.32 B

ATOM 7150 O LYS B 274 -2.020-36.061-69.3271.0065.21 B

ATOM 7151 N PRO B 275 -2.520-38.254-69.3761.0065.24 B

ATOM 7152 CD PRO B 275 -2.099-39.438-68.6071.0Q 65.62 B

ATOM 7153 CA PRO B 275 -2.253-38.404-70.810 1.0066.55 B

ATOM 7154 CB PRO B 275 -1.411-39.67^-70.8741.0066.34 B

ATOM 7155 CG PRO B 275 -1.819-40.456-69.6741.0065.56 B

ATOM 7156 C PRO B 275 -3.540-38.585-71.6101.0067.38 B

ATOM 7157 O ^"PRO B 275 -4.622-38.654-71.0281.0067.20 B

AΈOM 7158 N ALA B 276 -3.415 -38τ662 -72.931 1.00-68.18 B

ATOM 7159 CA ALA B_276 -3.859-37.583-73,805 1.00-68,57 B

ATOM 7K(TCB ALAB276 -2.999 -37.528_-75.0591.0068732 B

ATOM- 7161 C AL-AB-226 -5τ330-=37.743 -74.1741.0069.08 B

ATOM 7162 O ALAB^~276 -5.852-38.-857-74:213 1.0068.14 B

ATOM 7163 -N ALAB-277 -5.993^~-36.623 -74.443 1.0070.04 B

ATOM 7164 CA ALA B 277 -7.379-36.644-74.8971.0071.40 B

ATOM 7165 CB ALA B 277 -8.284 -35.9&6 -73.8661.0070.14 B

ATOM 7166 C ALA B 277 -7.526-35.958-76.251 1.0072.83 B

ATOM 7167 O ALA B 277 -8.562-35.364-76.5481.0074.35 B

ATOM 7168 N ALA B 278 -6.482-36.046-77.0691.0073.67 B

ATOM 7169 CA ALA B 278 -6.648-36.195-78.510 1.0074.27 B

ATOM 7170 CB ALA B 278 -5.743-35.224-79.2521.0074.17 B ATOM 7171 C ALA B 278 -6.371-37.628-78.951 1.0074.53 B

ATOM 7172 O ALA B 278 -5.247-38.117-78.8341.0074.53 B

ATOM 7173 N VAL B 279 -7.401-38.296-79.4601.0074.27 B

ATOM 7174 CA VAL B 279 -7.326-39.725-79.7391.0073.31 B ATOM 7175 CB VAL B 279 -8.716-40.384-79.685 1.0073.17 B

ATOM 7176 CGl VAL B 279 -8.689 -41:740 -80.3741.0074.36 B

ATOM 7177 CG2VALB279 -9.186-40.520-78.2451.0071.95 B

ATOM 7178 C VALB 279 -6.701-39.987-81.1061.0073.12 B

ATOM 7179 O VAL B 279 -6.637-41.129-81.560 1.0073.40 B ATOM 7180 N THRB 280 -6.243-38.922-81.7561.0072.70 B

ATOM 7181 CA THR B 280 -5.780-3.9.008 -83.135 1.007&SΘ B

ATOM 7182 CB THRB 280- -5:066-37.707-83.5471.0071.20 B-

ATOM 7183 OGl THR B 280 -6.015-36.635-83.601 1.0071.26 B

ATOM 7184 CG2 THR B 280 -4.565 -37,804 -84.9801.0070.13 B ATOM 7185 C THRB 280 -4.850-40.200-83.3321.0069.48 B

ATOM 7186 O THRB 280 -5.134-41.097-84.1261.0068.67 B

ATOM 7187 N SERB 281 -3.738 -40.204 -82.604 1.0068.41 B

ATOM 718S CA SERB 281 -2.711-41.226-82.7791.0067.77 B

ATOM 7189 CB SERB 281 -1.479 -40.893 -81.931 LOO 67.08 B ATOM 7190 OG SERB 281 -1.840-40.615-80.5961.0068.17 B

ATOM 7191 C SERB 281 -3.226-42,625-82.442 LOO 67.28 B

ATOM 7192 O SERB 281 -2.719 -43.620 -«2.9601.0066.75 B

ATOM 7193 N THRB-282 -4.231 -42.7ΘΘ -81.575 1M6Z56 B

ATOM 71-94 CA THR B 282 -4:808 -43.986.-81,201 1.0066.56 B ATOM- 7195 CB THR B 282 =5^818-43.850-80.0291.0067.21 B^~

ATOM 7196 OGl THRB282 -51141 -43.381-78.8521.0066.81 E- ATOM- 7197 CG2 THRB 282 -6.473 -45.195 -79 -.731 1.00.6735^" B

ATOM 7198 C THRB282 -5.539-44.519-82.4241.0065.98 B

ATOM 7199 O THR B 282 -5.660-45.729-82.6061.00-65.78 B ATOM 7200 N MET B 283 -6.022-43,598-83.258 1.0065.-18 B

ATOM 7201 CA MET B 283 -6.739-43.956-84.4791.0064.20 B

ATOM 7202 CB MET B 283 -7.462 -42.735 -85.0641.0063.25 B

ATOM 7203 CG MET B 283 -8.564-42.156-84.1941.0061.60 B

ATOM 7204 SD MET B 283 -9.358-40.705-84.933 1.0059.65 B _m

ATOM 7205 CE MET B 283 -11.017-41.304-85.1691.0059.91 B

ATOM 7206 C MET B 283 -5.766-44.503-85.521 1.0064.49 B

ATOM 7207 O MET B 283 -5.907-45.637-85.983 LOO 64.71 B

ATOM 7208 N LEU B 284 -4.781 -43.690-85.8891.0063.88 B ATOM 7209 CA LEU B 284 -3.-792-44.094-86.8781.0063.34 B

ATOM 7210 CB LEU B 284 -2.687-43.035-87.003 1.0062.89 B

ATOM 7211 CG LEU B 284 -3.033-41.677-87.625 1.0062.80 B

ATOM 7212 CDl LEU B 284 -1.790 -40.805 -87.651 1.0062.34 B

ATOM 7213 CD2LEUB284 -3.572-41.869-89.0371.0063.36 B ATOM 7214 C LEU B 284 -3.158-45.443-86.549 1.0063.39 B

ATOM 721-5 O LEU B 284 -2.931-46255-87.445 1.0063.72 B

ATOM 7216 N GLN-B 285 -3.015-45.749-85.278 1.0063.21 B

ATOM 7217 CA GLN B 285 -2.314-46.939-84.835 1.0062.83 B

ATOM 7218 CB GLN B 285 4.962.-46.838-83.372 1.0062.67 B ATOM 7219 CGGLN B 285 -0.5L2 -46=829 -83.018 1.0062.26 B

ATOM 7220 CD GLN B 285 -0.167-45.889-81.8720.0062.36 B

ATOM 7221 OEl GLN B 285 0.531-44.898-82.0530.0062.34 B

ATOM 7222 NE2 GLN B 285 -0.657-46.201-80.6950.0062.34 B

ATOM 7223 C GLN B 285 -3.130-48.157-84.9561.0063.20 B ATOM 7224 O GLN B 285 -2.742-49.172-84.4741.00.63.50 B

ATOM 7225 N GLN B 286 -4.292-48.048-85.5421.0063,81 B-

AIOM 7226 CA. GLN B- 286 -5.053. -4-9.237 -85.800 l.QΘ-65.00 B

ATOM 7227 CB GLN B 286 -6.101 -49.544 -84.750 1.0064Λ6 B

ATOM 7228 GG GTJSTB 286 -6J25-48J96 -84.001 1.0063.00 B ATOM 7229 CD GLN B^~28ό -7.45.0-48.S38 -82.801 1,0062,00 B

ATOM^" 7230 OEl GLNB 286 -8,603 -49J56 -82.8661.006θ:20 B

ATOM 7231 NE2GLNB2S6 -6.769 -48.866-81:693 1.0061.54 B

ATOM 7232 C GLN B 286 -5.698 -49.147-87.118, 1-.0066=60 B

ATOM 7233 O GLN B 286 -6.757-49.697-87.3461.0066.70 B ATOM 7234 N GLY B 287 -5.051-48.428-88.030 1.0067.72 B

ATOM 7235 CA GLY B 287 -5.440-48.441-89.428 1.0068.48 B

ATOM 7236 C GLY B 287 -6.854-47.940-89.645 1.0069.07 B

ATOM 72370 GLY B 287 -7.611-48.509-90.431 1.0069.61 B

ATOM 7238 N TRP B 288 -7.212-46.869-88.943 1.0069.05 B ATOM 7239 CA TRP B 288 -8.532-46.267-89.0841.0069.17 B

ATOM 7240 CB TRPB 288 -8.744-45.184-88.025 1.0069.47 B

ATOM 7241 CG TRP B 288 -9.540-45.648-86.843 1.0069.17 B

ATOM 72^'42 CD2 TRP B 288 -10.821 -45.162 -86.425 1.0068.11 B ATOM 7243 CE2TRPB288 -11.189-45.883-85.271 1.0067.71 B

ATOM 7244CE3 TRP B 288 -11.699-44.187-86.911 1.0067.90 B

ATOM 7245 CDl TRP B 288 -9.192-46.619-85.9491.0069.41 B

ATOM 7246 NEl TRP B 288 -10.176-46.767-85.0021.0069.25 B

ATOM 7247 CZ2 TRP B 288 -12.389-45.661-84.6001.0066.69 B ATOM 7248 CZ3TRPB288 -12.889-43.968-86.2421.0067.63 B

ATOM 7249 CH2 TRP B 288 -13.222-44,701-85.1001.0066.67 B

ATOM 7250 C TRPB2S8 -8.727-45.681-90.4791.0069.05 B

ATOM 7251 O TRP B 288 -8.028-44.748-90.8741.0069.33 B

ATOM- 7252 N ASNB 289 -9.827-46.039-91.1061.0068.68 B ATOM 7253 CA ASN B 289 -10.122-45.800-92.5081.0067.30 B

ATOM 7254 CB ASN B 289 -11.088-46.886-92.9601.0067.20 B

ATOM 7255 CG ASN B 289 -10.628-47.603-94.1301.0067.35 B

ATOM 7256 ODl ASN B 289 -11.407-47.970-94.9451.0067.97 B

ATOM 7257 ND2 ASN B 289 -9.354-47.837-94.218 1.0067.51 B ATOM 7258 C ASNB 289 -10.891-44-562-92.7451.00-66.19 B

ATOM^" 7259 O ASN B 289 -11.754-44.212-92.0081.0066148 B

ATOM ^"7200 N ALA-π-290 -10.739 -43,990 -93.8961.0064.84- B

ATOM 7261 CA ALA B 290 -11.638-42.882-94.1951.0063.39 B

ATOM 7262 CB ALA-B-290 -11.269 -42.243 -9S.-5251.00-63J2§_- B ATOM 7263 C ALA B 290 -13.093 -43.339 -94.2071.0062.02 B

ATOM 7264-O ALA B 29$ -13.997 -42.573 -93:8731.0061.Ol B

ATOM 7265 N THRrB 291 -13.311-44.592-94.59-1 h0061τ38 B

ATOM 7266- CA THR B 291 -14.659 -45.137 -94.702 1.0060.32 B

ATOM 7267 CB THRB 291 -14.708-46.241-95.7741.0060.41 B ATOM 7268 OGl THRB 291 -13.980-45.817-96.9331.0059.55 B

ATOM 7269 CG2 THRB 291 -16.126-46.414-96.2951.0060.90 B

ATOM 7270 C THRB 291 -15.143-45.685-93.3631.0059.28 B

ATOM 7271 O THRB 291 -16.332-45.627-93.0501.0059.12 B

ATOM 7272 N HTS B 292 -14.213-46.216-92.5771.0058.15 B ATOM 7273 CA fflS B 292 -14.542 -46.783 -91.272 1.00 56.88 B

ATOM 7274 CB IDS B 292 -13.306 -47.440 -90.644 1.0058.47 B

ATOM 7275 CG HIS B 292 -13.590 -48.193 -89.377 1.00 59.90 B

ATOM 7276 CD2 HIS B 292 -13.101 -48.045 -88.121 1.00 60.26 B- ATOM 7277 NDl HIS B 292 -14.471 -49.254 -89.322 1.00 60.90 B

ATOM 7278 CEl HIS B 292 -14.5115 -49:725 -88.088 1.0061.17 B

ATOM 7279 NΕ2 HIS B 292 -13.694 -49.009 -87.339 1.00 60.99 B

ATOM 7280 C HIS B 292 -15.034 -45.646 -90.388 1.00 55.01 B

ATOM 7281 O HIS B 292 -T5.935 -45.826 -89.567 1.00 54.04 B ATOM 7282 N MET B 293 -14.443 -44.468 -90.570 1.00 53.31 B

ATOM 7285 -CA METΕ 293 -14:-833 -43.294-89.799 1.00 51.32 B-

ATOM- 7284 CB MET B 293 -13.961 -421082 -90.179- 1.00 50.39 B

ATOM 7285 CG MET B 293 -12.519 -42.162 -89.659 1.00 50.23 B

ATOM 7286 SD MET B 293 -11.416 -40.803 -90.150 1.00 50.22 B ATOM 7287 CE MET B 293 -11.958 -39.528 -89.096 1.00 51.58 B

ATOM 7288 C MET B 293 -16.316 -42.986 -90.022 1.0050.58 B

ATOM 7289 O MET B 293 -17.068 -42.835 -89.057 1.00 51,16 B

ATOM 7290 N PHE B 294 -16.742 -42.915 -91.283 1.0049.52 B

ATOM 7291 CA PHE B 294 -18.145 -42.628 -91.597 1.00 48.60 B ATOM 7292 CB PHE B 294 -18.345 -42.399 -93.099 LOG 47.08 B

ATOM 7233. CG- PHEJ3-294 -17:818 -41:086 -93.594 1.00-44.74 B

ATOM 7294^' CUl PHE B 294 -16.475 -40.932 -93.90.0 LOO 44.44 R

AT9M 7295^" CD2- PHEJB 294 -18.668-=39>999 -93.752 1.00 43.81 B

ATOM 7296 CEl PHE B 294 -1-5.990 -39.717 -94^354 LflO 44.73 B ATOM 7297^" CE2 PHE B 294 -L8:t90-.3.8.781 -94.204 LOO 43.84 B

ATOM 7298 CZ PHE B 294 -16.8-51 -3«.639^"-94.507 1.0044rr6 B

ATOM 7299 C PHRB-294 -19.103-43.725 -91.141 1.0048.75 B

ATOM 7300 O PHE B 294 -20,298 -43.4-77 -90.970 1.0047.53 B

ATOM 7301 N ARG B 295 -18.569 -44.910 -90.907 1.0049.32 B ATOM 7302^" CA ARG B 295 -19.372 -46.040 -90.469 1.00 50.26 JB

ATOM 7303 CB ARG B 295 -18.893 -47.370 -91.043 1.00 50.60 B

ATOM 7304 CG ARG B 295 -19.365 -47.673 -92.461 1.00 52.42 B

ATOM 7305 CD ARG B 295 -20.343 -48.803 -92.664 1.0054.07 B

ATOM 7306 NE ARG B 295 -20.704 -49.076 -94.063 1.0056.47 B ATOM 7307 CZ ARGB 295 -19.939-49.672-94.9971.0057.23 B

ATOM 7308 NHl ARG B 295 -18.709-50.071-94.771 1.0057.09 B

ATOM 7309 NH2 ARG B 295 -20.412-49.849-96.196 1.0057.74 B

ATOM 7310 C ARGB 295 -19.439-46.137-89.003 1.0050.16 B ATOM 7311 O ARG B 295 -20.228-46r868--8S.48S 1.0049.80 B

ATOM 7312 N VAL B 296 -18.608 -45.361 -88.337 LOO 51.02^" B-

ATOM 7313 CA VAL B 296 -18.615-45.227-86.881 1.0051.29 B

ATOM 7314 CB VAL B 296 -17.257-44.726-86.355 1.0050.60 B

ATOM 7315 CGl VAE B 296 -17.367-44.358 -84.88-7 LOU 49.32 B ATOM 7316 CG2 VALB 296 -1.6.208 -45.795 -86.5491.0050.75 B

ATOM- 7317 C VAL B 296 -19.672-44.186-86:5401.005-1.S5 B

ATOM 7318 O -VALB-29.6 -20.403---44.314 -85.5551:0052.22 B

ATOM 7319 N ALAB 297 -19.735-43.146-87.366 1.0051.60 B

ATOM 7320 CA ALA B 297 -20.707-42.085-87.1-75 1.0051.60 B ATOM 7321 CB ALAB 297 -20.439 -4U.93S -88.141 1. OU 49.51 B

ATOM 7322 C ALA B 297 -22.075-42.690-87.4341.0051.83 B

ATOM 7323 O ALA B 297 -23.024-42.437-86:6941.0051.69 B

ATOM 7324 N GLU B 298 -22.174-43.502-88.4821.0052.66 B

ATOM 7325 CA GLU B 298 -23.442-44.138-88.8081.6054.12 B ATOM 7326 CB GLU B 298 -23.312-45.027-90.0391.0055.63 B

ATOM 7327 CG ~GLU B 298 -24.5631-45.860-90.30500-56.50 B

ATOM 7328 CD GLU B 298 -24.530 -46 S4T-91.651 1.00^'5739 B

ATOM- 7329. OEL GLU B -298 -23.608-47-361-9.1:8941.00-57.90 B^

ATOM 7330 OE-TGLUB 298 -25,432-46.263-92.4681.0058.40 B ATOM 7331 C GLU B- 298 -23.870 -^~Φ£9%5 -87.631- 1.0054.8Jr R

A3P3M 7332 O GLTJB 298 -25.013-44.907-87.174 1.0054.55- ÷B_

ATΘM 7333- N GLUB 299 --22.995-45:826- -81.167 LOO 55.93 B

ATOM 7334 CA -GLU B 299 -23.321-46.625-86.0231.0057.13 B-

ATOM 7335 CB GLU B 299 -22:058-47.159-85.4681.0059.00 B ATOM 7336 CG GLU B 299 -22.082-47.394-83.998 1.0063.65 B

ATOM 7337 CD GLU B 299 -20.765-47.086-83.321 1.0066.21 B

ATOM 7338 OEl GLUB 299 -20.578-45.954-82.905 1.0067.81 B

ATOM 7339 OE2 GLU B 299 -19.921-47.966-83.1971.0067.52 B

ATOM 7340 C GLU B 299 -24.025-45.800-84.9951.0056.38 B ATOM 7341 O GLU B 299 -25.165-45.986-84.7191.0056.78 B

ATOM 7342 N PHE B 300 -23.346-44.828-84.455 1.0054.34 B

ATOM 7343 CA PHE B 300 -23.951-44.049-83.388 1.0051.53 B

ATOM 7344 CB PHE B 300 -23.119 -42.78S -83.125 LOO 50.38 B ATOM 7345 CG PHE B 300 -23=412-42.133-81.8041.0048.99 B

ATOM 7346 CDl PHE B 300 -22.516-42.237-80.751 1.0045.84 B

ATOM 7347 CD2 PHE B 300 -24.595-41.428-81.6061.0048.25 B

ATOM 7348 CEl PHE B 300 -22.796 -41.648 -79.522 1.0048.35 B

ATOM 7349 CE2 PHEB 300 -24.885 -40.837 -S0.3821.0046.80 B ATOM 7350 CZ PHEB 300 -23.987-40.946-79.3391.0046.90 B

ATOM 7351 C EHE B 300 -25τ392 -43.661 -«3.7271:0050.66 B

ATOM 7352 O PHE B 300 -26.305-43.918-82.948 1.0050.67 B

ATOM 7353 N PHE B 301 -25.595-43.047-84.889 1.0049.87 B

ATOM 7354 CA PHE B 301 -26.928-42.613-85.3141.0049.03 B ATOM 7355 CB PHE B 301 -26.888-42.059-86.734 1.0048.30 B^~

ATOM 7356 CG PHE B 301 -26.547-40.605-86.822 1.0046.96 B

ATOM 7357 CDl PHE B 301 -25.234 -40.197 -87.028 LOO 46.04 B

ATOM 7358 CD2 PHEB 301 -27.548-39.641-86.7491.0046.47 B

ATOM 7359 CEl PHE B 301 -24.922-38.856-87.167 1.0044.67 B ATOM 7360 CE2 PHE B 301 -27.246-38.295-86.8871.0045.55 B

ATOM 736-1 CZ PHE B 301 -25.930-37.903-87.0971.0045.08- -B

ATOM 7362 C PHEB-JGl -2S-.Θ08 -43:.ό.87 -85.277 LOO 48.85 B

ATOM 7363 O -P.HE-B-301 -29,-171 -43.397-84.996 l.ΦΘ-47.72 B

ATOM 7364 N THRB 302 -27.62S-44.920^~=35.5961.0049.24 B ATΘM 73,65 CA THR«3O2 -28.576 -46^3I -85.6191.0050.05 B^~

ATOM 7366 CB THRB3Θ2 -27.995=47.250-80891.00-48.-64 .B-

ATOM 7367 OGl THR B 302 -26.667 -47.525 --85.938 170048.59- B^~

ATOM 7368 CG2 THR B 302 -27.952 -46.967 -87.875 JLOO 48.67 B

ATOM 7369 C THRB 302 -28.984-46.464-84.213-1.00.51.24 B ATOM 7370 O THRB 302 -30.145-46.803-83.9691.0051.73 B

ATOM 7371 N SER B 303 -28.023-46.435-83.2941.0051.94 B

ATOM 7372 CA SERB 303 -28.248-46.818-81.9061.0052.64 B

ATOM 7373 CB SERB 303 -26.941-46.690-81.1291.0054.20 B

ATOM 7374 OG SERB 303 -25.901-47.382-81.8131.0057.91 B _3Q3

ATOM 7375 C SER B 303 -29.340-45.994-81.233 1.0052.02 B

ATOM 73760 SERB 303 -29.926-46.432-80.2501.0052.06 B

ATOM 7377 N LEU B 304 -29.606-44.802-81.761 1.0051.35 B

ATOM 7378 CA LEUB 304 -30.650-43.932-81.2241.0050.47 B ATOM 7379 CB LEUB 304 -30.291-42.468-81.4341.0049.84 B

ATOM 7380 CG LEU B 304 -29.000-42.012-80.7781.0049.70 B

ATOM 7381 CDl LEUB 304 -28.625-40.639-81.296 1.0050.27 B

ATOM 7382 CD2 LEU B 304 -29.181-42.017-79.272 1.0050.22 B

ATOM 7383 C LEUB 304 -31.898-44.239-82.011 1.0050.40 B ATOM 7384 O LEUB 304 -32.908-43.548-81.9001.0049.72 B

ATOM 7385 N GLU B 305 -31.801-45.285-82.821 1.005-1.01 B

ATOM 7386 CA GLU B 305 -32.890-45.733-83.6721.0051.68 B

ATOM 7387 CB GLUB 305 -34.049-46.270-82.833 1.0052.20 B

ATOM 7388 CG GLU B 305 -33.868-47.726-82.451 1.0052.80 B ATOM 7389 CD GLU B 305 -35.041 -48.276 -81.671 1.0054.06 B

ATOM 7390 OEl GLU B 305 -35.197-47.920-80.4861.0054.47 B

ATOM 7391 OE2GLUB3Λ5 -35.818-49.064-82.2501.0055.72 B

ATOM 7392 C GLU B 305 -33.373 -44.664 -84.643 1.0051.92 B

ATOM 7393 G GLUB 305 -34.556-44.309-84.691 1.0051.00 B ATOM 7394 N LEU B 306 -32.410-44.149-85.3991.0052.28 B

ATOM 7395 CA LEU B 306^~ -32.645-43.168-86.4471.0052.41 B

ATOM 7396 CB LEUB 306 -31.722 -41.960 -86.274- 1.0051.86 B

ATOM 7397 CG LEU B-306 -3 L990 -41.020 -85.0961.0050r88 B

ATOM 7398 CDl LEU^'S 306 -3O.8-30-40.065 -84.9601.0050.95 B ATOM 7399 GD2JLEU-B 306 -33.29-0-40.261 -.85r303 1.0048.98 B

ATOM 74O0 C LEU B 306 -32.230-44.000-87.6641.0052:75 B

ATOM 7401 O LEU B 306 -31.444-44.947-8775191.0053τl8 B

ATOM 7402 N SERB 307 -32.753-43.686-88.848 1.0052.03 B

ATOM 7403 CA SERB 307 -32.405 -44=467-90.037 LOO 50.10 B ATOM 7404 CB SERB 307 -33.274-44.052-91.223 1.0050.33 B

ATOM 7405 OG SERB 307 -33.229-42.654-91.4261.0050.38 B

ATOM 7406 C SER B 307 -30.932-44.352-90.409 1.0048.48 B

ATOM 7407 O SER B 307 -30.283-43.343-90.1201.0046.77 B

ATOM 7408 N PRO B 308 -30.378-45.407-91.0341.0048.01 B ATOM 7409 CD PRO B 308 -30.974-46.749-91.1841.0047.11 B

ATOM 7410 CA PRO B 308 -28.971-45.420-91.4461.0048.04 B

ATOM 7411 CB PROB 308 -28.630-46.906-91.4561.0046.53 B

ATOM 7412 CG PRO B 308 -29.894-47.509-91.9441.0046.92 B ATOM 7413 C PRO B 308 -28.763-44.766-92.8101.0048:45 B

ATOM 7414 O PROB 308 -29.722-44.399-93.4921.0048.31 B

ATOM 7415 N MET B 309 -27.499-44.632-93.196 1.0049.00 B

ATOM 7416 CA METB 309 -27.130-44.018-94.461 1.0050.21 B

ATOM 7417 CB METB 309 -25.643-43.658-94.438 1.0052.23 B ATOM 7418 CG METB 309 -25.239-42.716-93.306 1.0054.16 B

ATOM 7419 SD METB 309 -26.026-41.079-93.4041.0057.33 B

ATOM 7420 CE METB 309 -27.391-41.266-92.2271.0056.32 B

ATOM 7421 C METB 309 -27.415-44.940-95.6381.0050.62 B

ATOM 7422 O MET B 309 -26.839-46.029-95.7241.0051.08 B ATOM 7423 N PRO B 310 -28.301-44.509-96.565 1.0050.95 B

ATOM 7424 CD PRO B 310 -29.013-43.229-96.4241.0051.64 B

ATOM 7425 CA PROB 310 -28.749-45.199-97:785 1.0050=63- B

ATOM 7426 CB PRO B 310 -29.628-44.161-98.4671.0050.97 B

ATOM 7427 CG PRO B 3-10 -30.212-43.436-97.315 1.0052.19 B ATOM 7428 C PROB 310 -27.632 -45_^666 -98.708- 1.0050.75 B

ATOM 7429 O ^"PROB 310 -26.534 -45.11& -98.7-02^" 1.D049.35 B

ATOM 7460 -N PROB 311 -27:905-46,697-99.521 1.0052.26 B

ATOM 7431 CD PRO B 311 -29-7074 -47.597 -99.509- LOO 52.62. B

ATOM: 7432 CA ERΘ-B-31-1 -26.875 -47.196-100:435 LOθ 53T26 B ATOM 7433 CB PRQ-B3.il -27.575 -48-36L- 101.1-31 1.0052.93 B

ATOM 74-34 CG PRO B 311 -2&49X) -48τ883-100.062 U30-52.28 B

ATOM 7435 C -PROJB 311 -26.414 -46.118-101.408- 1.0053-82 B

ATOM 7436 O PROB 311 -25.224-46.017-101.711 1.0053.65 B

ATOM 7437 N GLUB 312 -27.353-45.309-101.8901.0054.28 B ATOM 7438 CA GLUB 312 -27.001-44.248-102.823 1.0055.41 B

ATOM 7439 CB GLUB 312 -28.226-43.412-103.211 1.0057.24 B

ATOM 7440 CG GLUB 312 -29.531-43.769-102.5041.0060.17 B

ATOM 7441 CD GLU B 312 -30.542-44.445-103.411 1.0062.02 B

ATOM 7442 OEl GLUB 312 -30.492-45.688-103.531 1.0062.26 B ATOM 7443 OE2 GLUB 312 -31.380-43.729-104.003 1.0063.75 B

ATOM 7444 C GLUB 312 -25.956-43.352-102.1861.0055.14 B

ATOM 7445 O GLUB 312 -25.107-42.788-102.881 1.0055.72 B

ATOM 7446 N PHEB 313 -26.026-43.229-100.862 1.0054.81 B ATOM 7447 CA PHE B 313 -^"25.084 -42.4L5-100.098 1.0054.20 B

ATOM 7448 CB PHE B 313 -25.501-42.366-98.6191.0053.56 B

ATOM 7449 CG PHE B 313 -24.461-41.755-97.7051.0053.96 B

ATOM 7450 CDl PHE B 313 -24.287 -40.368 -97.6401.0053.97 B

ATOM 7451 CD2 PHE B 313 -23.629-42.572-96.9341.0053.22 B ATOM 7452 CEl PHE B 313 -23.298-39.805-96.825 1.0053.34 ^"B

ATOM 7453 CE2 PHE B 313 -22.640-42.024-96.1171.0052.89 B

ATOM 7454 CZ- PHEB 313 -22.472-40.635-96.063 1.00-53.40 -B

ATOM 7455 C PHEB 313 -23.669-42.992-100.2241.0054.08 B

ATOM 74560 PHEB 313 -22J724 -42.270-100^43 1.0054.19 B ATOM 7457 N TRP B 314 -23.526 -44.292 -99.978 1.0053.44 B

ATOM 7458 CA TRPB 3-14 -22.227-44.941-100.0641.0052.83 B

ATOM 7459 CB TRPB 314 -22.295-46.332-99.432 1.0052J29 B

ATOM 7460 CG TRP B 314 -22.616-46.255-97.9751.0052.93 B

ATOM 7461 CD2 TRPB 314 -21.684-46.026-96.909 1.0053.40 B ATOM 7462 CE2 TRP B 314 -22.436-45,871-95.7201.0052.89 B

ATOM 7463 CE3TRPB3-14 -20.285-45.927-96.8441.0052.73 B

ATOM 7464 CDl TRP B 3.14 -23.861 -46.242 -97.4041.0052.32 B-

ATΘM 7465 NEl TRP B 3-14 -23.760-46.010-96.0481.0052.62 B

ATOM 7466-CZ2 TRPB 3-14 --21:835-45.621-94.4841:0052.10 B ATOM 7467 CZ3 TRP B 314 -19.690-45.679 -95..6171.0051.83 B-

ATOM 746S CHTTRP-B 314 -20.465-45.528-94.451 1.00-51.78^" B^~

ATOM 7469 C TRPB 314 -21.762 -45.032-10L503 1.0053.55 B

ATOM 7470 O TRPB 3L4 -20.566-45.041-101.7801.0053.48. B

ATOM 7471 N GLUB.315 -22.713-45.061-102.4161.0054.70 B ATOM 7472 CA GLU B 315 -22.417-45.177-103.8391.0055.43 B

ATOM 7473 CB GLUB 315 -23.671-45.586-104.6141.0058.77 B

ATOM 7474 CG GLUB 315 -23.599-46.978-105.2221.0063.61 B

ATOM 7475 CD GLUB 315 -24.781-47.844-104.8341.0065.26 B

ATOM 7476 OEl GLUB 315 -24.557-48.969-104.3391.0065.06 B ATOM 7477 OE2 GLUB 315 -25.934-47.402-105.0261.0067.31 B

ATOM 7478 C GLUB 315 -21.860-43.871-104.395 1.0053.88 B

ATOM 74790 GLUB 315 -20.832-43.890-105.0981.0052.60 B

ATOM 7480 N GLYB 316 -22.517-42.754-104.1361.0052.87 B ATOM 7481 CA GLY B 316 -22.074-41.474-104.671 1.0052.06 B

ATOM 74S2. C GLY .B 316 -21.190-40.543-103.845 1.0050.71 B

ATOM 7483 O GLYB 316 -20.387-39.795-104.4001.0050.69 B

ATOM 7484 N SERB 317 -21.332-40.574-102.5291.0049.78 B

ATOM 7485^""CA SERB-317 -20.550-39.709-101.6541.0048.80 B ATOM 74S6 CB SERB 317 -20.873-40.064-100.1901.0049.55 B

ATOM 7487 OG SERB-317 -20.389-39.105-99.261 -1.0051.22 B

ATOM 7488 C SERB 317 -19.034-39.791-101.9141.0047.89 B

ATOM 74890 SERB 317 -18.486-40.867-102.1371.0046.70 B

ATOM 7490 N METB 318 -18.371-38.637-101.9101.0047.79 B ATOM 749T CA MET B 318 -16.919-38.562-1=02.101 1.0048.09 B

ATOM 7492 CB METB 318 -16.541 -37J20-102.9271.0047.90 B

ATOM 7493 CG METB 318 -15.030-37.128-103.1041.0048.25 B

ATOM 7494 SD METB 318 -14.528-35.545-103.831 1.0049.77 B-

ATOM 7495 CE METB 318 -14.076-34.605-102.3881.0049.10 B ATOM 7496 C METB 318 -16.319-3:8.445-100.696.1.0048.19 B

ATOM 7497^~O -METB 318 -16.215-37349-100.1561.0048.60 B

ATOM 7498 N- LEU-B 319 -15.914-39,568-100.112 LOO 48.43- B-

ATOM..7499 -CA LEUJBL31-9 -15.379 -39.567 -98.755 1.0048.44 B

ATOM 7500 CB LEUB 319 -15:832 -40.837 -98^033 1.004:6.97 B ATQM 7501 CG LEU B-319 -17.301-41.230-98.235 1.0045.66 B

ATOM 7502 CDl L-EU B-31-9 -17.577 -42.52I-97τ493 1.0044.48- B

ATOM_ 7503 CD2 LEU B 319 -18.227-40.119 -97.760 1.0043,43 B

ATOM 7504 C LEU B 3-15 -13.868-39.426-98.628 1.0049,96 B

ATOM 7505 O LEU-B 319 -13.345-39.448-97.5221.0050.38 B ATOM 7506 N GLU B 320 -13.151 -39.179 -99.706.1.0052.33 B

ATOM 7507 CA GLU B 320 -11.690-39.134-99.675 1.0054.83 B

ATOM 7508 CB GLU B 320 -11.158-40.470-100.0841.0055.60 B

ATOM 7509 CG GLU B 320 -10.435-41.310-99.068 1.0058.16 B

ATOM 7510 CD GLU B 320 -10.738-42.777-99.237 1.0059.94 B ATOM 7511 OEl GLUB 320 -11.724 -43.106 -99.884 1.00 61.71 B

ATOM 7512 OE2 GLU B 320 -9.991 -43.603 -98.729 1.00 60.61 B

ATOM 7513 C GLU B 320 -11.289 -38.185-100.760 1.00 56.11 B

ATOM 7514 O GLU B 320 -12.085 -37.927-101.591 1.00 56.81 B ATOM 7515 N LYS-B-321 -L0.064-37.678-100:771 1.00 57.23 B

ATOM 7516 CA LYS E 321 -9.57O~36.774-101.812 1.00 5K16 B

ATOM 7517 CB LYS B 321 -8.406 -35.925-101.289 1.0058.03 B

ATOM 7518 CG LYS B 321 -7.825 -34.958-102.314 1.00 57.91 B

ATOM 7519 CD LYS B 321 -6.819-337998-101.685 h00 58.23 B ATOM 7520 CE LYS B 321 -6.193 -33.079^'- 102.725 1.00 59.06 B

ATOM 7521 NZ LYSΕ 321 -5.283 -32.080-102.106 1.00 58.96 B

ATOM 7522 C LYS.B 321 -9.120 -37.610-103.008- b00 58.96 B

ATOM 7523 0 LYS B 321 -8.317 -38.536-102.860 1.00 59.67 B

ATOM 7524 N PRO B 322 -9.635 -37.293-104.208 1.0059.46 B ATOM 7525 CD PRO B 322 -10.491 -36.125-104.489- 1.00 59.56 B

ATOM 7526 CA PRO B 322 -9.306 -38.005-405.448 1.00 59.46 B

ATOM 7527 CB PRO B 322 -9.776 -37.041-106.525 1.00 59.49 B

ATOM 7528 CG PRO B 322 -10.981 -36.415-105.884 1.0059.86 B

ATOM 7529 C PRO B 322 -7.830 -Ϊ8.373-105.598 1.00 59.89 B ATOM 7530 O PRO B 322 -6.940 -37.625-105.185 LOO 59.41 B

ATOM 7531 N ALAB.323- -7^86 -397539-106.191 1.00 60.58 B

ATOM 7532 CA ALA B 323 -6,230 -40.035-106.412 1.00 60.84 B

ATOM 7533 GB ALA B 323- -6.239 -41.569-106.488"-1.00-61.04 B

ATOM 7534 C ALA-B 323 -5.690 -39.445-107.711 1.00 60rS6 B_ ATOM 7535 O ALAB^~323 -4.539-39:003-107:777 1.00 60.40 B

-ATOM 7536 N ASP B 124 -6.545 -39.440-108.734 1.00-60:62 B

ATOM 7537 CA ASPB 324^* -£J2Q9 -3S.910-110.050 1.0059.84 B:

ATOM 7538 CB ASP B 324 -7.375 -39.140-111.018-1.00 59.77 B

ATOM 7539 CG ASP B 324 -8.681 -38.545-110,517 1.00 60.20 B ATOM 7540 ODl ASP B 324 -8.715 -37.315-110.302 1.00 60.26 B

ATOM 7541 OD2 ASP B 324 -9.667 -39.301-110.341 1.00 59.27 B

ATOM 7542 C ASP B 324 -5.864 -37.422-109.982 1.0059.85 B

ATOM 7543 O ASP B 324 -5.447 -36.825-110.972 1.00 59.68 B

ATOM 7544 N GLYB 325 -6.053 -36.827-108.809 1.00 60.28 B _30g

ATOM 7545 CA GLY B 325 -5.727 -35.426-108.618 1.00 60.00 B

ATOM 7546 C GLY B 325 -6.557 -34.396-109.354 1.00 59.96 B

ATOM 7547 O GLY B 325 -6.014 -33.371-109.772 1.0061.00 B

ATOM 7548 N ARGB_326 -7.856 -34.647-109.520 1.0058.60 B ATΘM 7549 CA ARG B 326 -8.737 -33.688-110.192 1:00-57.47- B

ATOM 7550 CB ARG B 326 -9.953 ^• -34.408-110.798 1.0.055.76^" B

ATOM 7551 CG ARG B 326 -10.698 -35.377-109.866 1.00 55.90 B

ATOM 7552 CD ARGB 326 -11.919 -36.009-110.564 1.00 55.13 B

ATOM ^"7553 NE^~ARGB 326 -12.199 -37.389-110.145 1,00 54.7-9- Br ATOM 7554 CZ ARG B 326 -13.028 -37.736.-109.164 1.0054.54 B

ATOM 7555 NHtARGB 326 -13.676 -36.808-røS478 1.0053:78 B

ATOM^" 7556 NH2 ARGJB 326 -13.215 -Ϊ9.016-A98-871 1.00 54.53 B

ATOM 7557 C ARGB 326 -9.195 -32.619-109.189 1.00 57.84 B

ATOM 7558 O ARGB 326 -9.927 -32.915-108.248 1.0038.57 B ATOM 7559 N GLUB 327 -8.828 -31.391-109.424 1.00 5-7.58 B

ATOM 7560 CA GLU B 327 -9.151 -30.416-108.463 1.00 57.99 B-

ATOM 7561 CB GLUB 327 -8.996 -29.053-109.051 1.0059.13 B

ATOM 7562 CG GLU B 327 -7.596 -28.780-109.540 1.00 61.73 B

ATOM 7563 CD GLU B 327 -6.680 -28.108-108.533 1.00 62.98 B ATOM 7564 OEl GLU B 327 -6.505 -26.907-108.613 1.00 63.20 B

ATOM 7565 OE2 GLU B 327 -6.093 -28.779-40X688 1.00 63.72 ^"B

ATOM 7566 C GLU B 327 -10.510 -30.673-107.961 I.θϋ^'57,50 B

A-TOM- 7567 O GLU B 327 -1L343 -3-1.154-10S.659-- 1,00 57.30 B

ATOM 7568..N VAirB-328 -10.754 -30.398-106,684 tOΘ-57.00 B ATOM 7569 GA VAL B 32-8 -12;094 -30.443-106:090- 1.0Q-55.1-9 B

ATOM 753Θ- GB-VAL B 328 -12.460 -31.831-105.50S- IrOO 53.91 B

ATOM 757T CGl VAL B 328 -12.448 -32.87fr-106-.594^~ l^:.0Q_5A28 B

ATOM 7572 CG2 VAL B 328 - 11.506^"- -32.189-104.373 1.0052.61 B

ATOM 7573 C VAL B 328 -12.206 -29.482-104.930 1.0054.64 B ATOM 7574 O VAL B- 328 -11.205 -28.972-104.429 1.00 55.42 B

ATOM 7575 N VAL B 329 -13.446 -29.243-104.520 1.00 53.30 B

ATOM 7576 CA VAL B 329 -13.736 -28.391-103.380 1.00 52.31 B

ATOM 7577 CB VAL B 329 -15.174 -27.825-103.459 1.0051.65 B

ATOM 7578 CGl VAL B 329 -15.491 -27.015-102.225 1.00 50.64 B _m

ATOM 7579 CG2 VAL B 329 -15.323-26.972-104.6991.0051.33 B

ATOM 7580 C VAL B 329 -13.627-29.367-102.2071.0052.54 B

ATOM 7581 O VAL B 329 -14.526-30.189-101.991 1.0052.36 B

ATOM 7582 N CYS B 330 -12.513-29.299-101.4761.0051.68 B ATOM 7583 CA CYS B 330 -12.281 -30.186-100.3391.0050.73^" B

ATOM 7S84 U CYS B 330 -13.086-29.867-99.073 1.0049.82 B

ATOM 75850 CYSB330 -13.197-30.711-98.177 1.0049.21 B

ATOM 7586 CB CYS B 330 -10.793-30.214-99.991 1.0051.73 B

ATOM 7587^" SG CYS B 330 -9.879 -31.6U8-100.722 LOO 56.85 B ATOM 7588 N HIS B 331 -13.677-28.722-99.0151.0048.53 B

ATOM 7589 CA HISB 331 -14.384 -28.426--97.8571.0047.51 B

ATOM 7590 CB HIS B 331 -15.081-27:156-98.028 1.0047.42 B^~

ATOM 7591 CG HIS B 331 -15.269-26.421-96.761 1.0048.71 B

ATOM 7592 CD2 HIS B 331 -14.179-25.859-95.9371.0049.23 B ATOM 7593 NDl HIS B 331 -16:496-26.179-96.2171.0049.51 B

ATOM 7594 CEl HIS B 331 -16.352-25.488-95.116 LOO 50.21 B

ATOM 7595 NE2 -HI-S B 331 -15.075-25.282-94.925 1.0050.01 B

ATOM 7596 C HISB 331 -15.419-29.410-97.7001.0046.60 B

ATOM 7597 O HIS B 331 -16.098-29.664-98.5971.0047.48 B ATOM 7598 N ALA B 332 -15.619 -29.8S8 -96.4971.0044.75 B

ATOM 7599 CA ALA B 332 -16.676 -3O.834 -96.132 LOO 42.81 B

ATOM 7600 CB ALA B 332 -16.539 -3-1.213 -94.665^" 1.00-43.46 B

ATOM 76Θ1 C ALAB 332 -18.090-30.321-96.408 LQ04L54 B

ATOM 7602 O- AEA B 332 48.446 -29J22-95v992 1.0041.71 B ATOM -7603 N SERB 333 -L8.&9o -31.-140 -97.0861.0039:95 B

ATOM 7604 -CA SER-B 333 -20.257 -3.0r753 -97.4301.0039.34 B

ATOM 7605 CB SERB 333 -20.259^"30.102 -98.81-0 l.WMΘfl? B

ATOM 7606 OG SER B 333 -19.181 -29.192 -98.943 1.0043J3 B

ATOM 7607 C SER B 333 -21.255-31.916-97.4261.0038.72 B ATOM 7608 O SERB 333 -20.891-33.061-97.680 1.0038.19 B

ATOM 7609 N ALA B 334 -22.517-31.596-97.1421.0037.76 B

ATOM 7610 CA ALA B 334 -23.603-32.570-97.1091.0037.28 B

ATOM 7611 CB ALAB 334 -24.260-32.577-95.740 1.0036.47 B

ATOM 7612 C ALA B 334 -24.609-32.155-98.175 1.0037.54 B ATOM 7613 0 ALA B 334 -25.140 -31.048 -98.145 1.00 37.40 B

ATOM 7614 N TRPB 335 -24.886 -33.062 -99.106 1.0038.33 B

ATOM 7615 CA TRP B.335 -25.784 -32.766-100.214 1.00 38.41 B

ATOM 7616 CB TRP B 335 -25.072 -33.078-101.528 1.00 36.68 B ATOM 7617 CG TRP B 335 -23.803 -32.344-101.716 1.00 34.64 B

ATOM 7618 CD2 TRP B 335 -23.491 -31.434-102.776 1.00 33.48 B

ATOM 7619 CE2 TRP B 335 -22.163 -31.004-102.579 1.00 32.92 B

ATOM 7620 CE3 TRP B 335 -24.204 -30.942-103.879 1.0031.95 B

ATOM 7621 CDl TRP B 335 -22.690 -32.425-100.937 1.00 34718 B ATOM 7622 NEl TRP B 335 -21.698 -31.622-101.447 1.0033.45 B

ATOM 7623: CZ2 TRP B 335 -21.531 -30.1G5-103.446 Ii)O 30.94 B

ATOM 7624 CZ3 TRP B-335 -23.573 -30.049-104.738 1.00 29.75 Ε

ATOM 7625 CH2 TRP B 335 -22.252 -29.643-104.515 1.0029.66 B

ATOM. 7626 C TRP B 335 -27.152 -33.430-100.255 1.00 39.18 B ATOM 7627 O TRP B 335 -27.277 -34.650-100.156 1.00 39Λ 6 B

ATOM 7628 N ASP B 336 -28.174 -32.606-100.439 1.00 39.43 B-

ATOM 7629 CA ASP B 336 -29.536 -33.097-100.551 l.QO 40.41 B

ATOM 7630 CB ASP B 336 -30.440 -32.406 -99.530 1.00 41.21 B

ATOM- 7631 CG ASP B 336 -31.906 -32.718 -99.739 1.0040.90 B ATOM 7632 ODl ASP B 336 -32.222 -33.821-100.238 1.0041.13 B

ATOM 7633 OD2 ASP B 336 -32.741 -31.858 -99.390 1.00 40.89 B

ATOM 7634 C ASP B 336 -30.-034 -32.826-101.971 1:00 40.33^" B

ATOM 7635 O ASP B 336 -3.0.460 -31.710- 102.2S6 LOX) 39.58 B

ATOM- 7636- -N PHE B 337 -29.964 -33,854-102.820 1.0040.17 BL A-TOMl 7637 CA PHE B 337 -30:391 -33^65-104.211- h00J39?82- B

ATOM 7-638 CB PHE B 337 -29.944 -35.007-104:977 1.0039.12 .B-

ATOM 7639 CG PHE B 337 -28.462 -35.079-105.214- l.GO^~41.OΘ B

ATOM 7640 CDl PHE B 337 -27.590 -35.400-104.183 1.00 41.73 B-

ATOM 7641 CD2 PHE B 337 -27.934 -34.845-106.486 1.0041.52 B ATOM 7642 CEl PHE B 337 -26.202 -35.492-104.415 1,00 42.84 B

ATOM 7643 CE2 PHE B 337 -26.551 -34.932-106.730 1.00 41.63 B

ATOM 7644 CZ PHE B 337 -25.686 -35.258-105.694 1.0042.07 B

ATOM 7645 C PHE B 337 -31.894 -33.561-104.421 1.00 40.14 B

ATOM 7646 O PHE B 337 -32.381 -33.664-105.544 1.00 40.24 B ATOM 7647 N TYRB 338 -32.623 -33.269-103.348 1.00 40.23 B

ATOM 7648 CA TYRB 338 -34.064 -33.033-103.428 1.0040.46 B

ATOM 7649 CB TYRB 338 -34.339 -31.613-103.920 1.0040.63 B

ATOM 7650 CG TYRJB 338 -34.168 -30.569-102.852 1.0042.58 B ATOM 7651 CDl TYR B 338 -32.909 -30.059-102.535 1.0042.35 B

ATOM 7652 CEl TYRB 338 -32.751 -29.118-101.523 1.0044.95 Ε

ATOM 7653 CD2 TYRB 338 -35.268 -30.114-102.129 1.0044.11 B

ATOM 7654 CE2 TYRB 338 -35.126 -29.181-101.116 1.0045.97 B

ATOM 7655 CZ TYRB 338 -33.867 -28.682-100.812 1.00 46.67 3 ATOM 7656 OH TYR B 338 -33.741 -27.755 -99.787 1.0049.64 B

ATOM 765-7 C TYRB 338 -34.865 -34.005-104.284 1.0040.55 B

ATOM 7658 O TYRB 338 -35.784 -33.595-104.9&8 1.00 39.91 B

ATOM 7659 N ASN B 339 -34.524 -35.288-104.214 1.0041.22 B

ATOM 7660 CA ASN B 339 -35.222 -36.316-104.978 1.00 40.28 B ATOM 7661 CB ASNΕ 339 -34.327 -36.842-106.101 1.0039.19 B

ATOM 7662 CG ASNB 339 -33.367 -37.923-105.630 1.0040.19 B

ATOM 7663 ODl ASN B 339 -32.890 -37.9Q1-104.495 1.0041.09 B

ATOM 7664 ND2 ASN B 339 -33.067-38.869-106.511 1.0040.47 B

ATOM 7665 C ASNB 339 -35.622 -37.473-104.065 1.0040.95 B ATOM 7666 O ASN B 339 -35.956 -38.549-104.545 1.0042.00 B

ATOM 7667 N ARG B 340 -35.569 -37.247-102.751 1.0040.55 B

ATOM 7668 CA ARGB 340 -35.928 -38-263-101:756 1.00 38.61 B

ATOM 7669 CB ARG B 340 -37.418 -38.598-101.850 1.00 37.59- B

ATOM 7670 CG- ARG B 340 :-38r3-48-37.486-101.432 1.0038:78 B- ATOM 7671 CD ARG B 340 -39.765 -37.719-101.942 UOO 39:23 B-

ATOM- 7672 NE ARG B 340 -39.840 -37.605-103.397 l.Qfl 40.32 _B

ATOM 7673 CZ ARG-B 340 -39.741 -38.620-104.254 1.00 40.18- B

ATOM 7674 NH-I ARG B 340 -39.568 -39.865-103.828 1.0041.25 B

ATOM 7675 NH2 ARG B 340 -39.803 -38.389-105.556 1.0041.21 B ATOM 7.676 C ARGB 340 -35.141 -39.559-101.876 1.0038.04 B

ATOM 7677 0 ARG B 340 -35.444 -40.525-101.185 1.00 39.27 B

ATOM 7678 N ALA B 341 -34.135 -39.600-102.741 1.00 37.34 B

ATOM 7679 CA ALA B 341 -33.373 -40.830-102.902 1.0037.80 B

ATOM 7680 CB ALA B 341 -33.865 -41.595-104.134 1.0037.33 B ATOM 7681 C ALA B 341 -31.872-40.638-102.983 1.0038.56 B

ATOM 76820 ALA B 341 -31.129-41.608-102.9321.0038.15 B

ATOM 7683 N ASPB 342 -31.416-39.399-103.121 1.0040.06 B

ATOM 7684 CA ASP B 342 -29.979-39.154-103.190 1.0041.24 B ATOM 7685 CB ASP B 342 -29.578-38.709-104.5921.0044.15 B

ATOM 7686 CG ASP-B 342 -28.754-39.755-105.313 1.0048.05 B

ATOM 7687 ODl ASP B 342 -27.670-40.140-104.8001.0049.49 B

ATOM 7688 OD2 ASP B 342 -29.203-40.195-106.3941.0050.22 B

ATOM 7689- C ASPB 342 -29.459-38.150-102.1701.0040.07 B ATOM 7690 O ASPB-342 -29.879-36.990-102.1441.0039.33 B

ATΘM ^"7691 N PHE B- 343 -28.548-38.621-101.3201.00-39.08 B

ATOM 7692 CA PHE B 343 -27.927-37.798-100.2871.0037.96 B

ATOM 7693 CB PHE B 343 -28.572-38.005-98.915 1.0035.15 B

ATOM 7694 CG PHE B 343 -30.049 -38.169-98.948 LOO 32.00 B ATOM 7695 CDl PHE B 343 -30.613 -3-9.398 -99.233 1.0011.15 B

ATOM 7696 CD2PHEB343 -30.877-37.100-98.6921.0030.96 B

ATOM 7697 CEl PHE B 343 -31.986-39.559-99.2481.0030.27 B

ATOM 7698 CE2 PHE B 343 -32.248 -37.255 -98.705 1.0X) 30.76 B

ATOM 7699 CZ PHE B 343 -32.802-38.485-98.988 1.0030.63 B ATOM 7700 C PHE-B343 -26.485-38.248-100.1891.0038.67- B

ATOM 7701 O PHE B 343 -26.216-39.438-100.022 1. OO 37.95 B

ATOM- 7702 N -ARGB 344 -25.558-37.303-100.2841.0039:83 B

ATOM 7703 CA ARG B 344 -24.Ϊ4& -37.640-100.201 1.0041.22 B

ATOM 7704 CB ARGB-344 -23.547 -3-7:133-101.606 L0θl42.S7 B ATOM : 7705 CG ARG B 344 -24.269-38.719-102.513 1.00-44.21 B

ATOM 7706 CD- ARG-B 344^~ -23.7O9~38.69T-iO3-.915 1:0043.81 B

ATOM 7707 NE ARGB 344 -24.775 -38.760-104:906- 1-004.4.99 B-

AIOM 7-7-88 CZ ARG B 344 -24.606-38.495-106.198 1.0045.22 B

ATOM- 7709 NHl ARG B 344 -23.405-38.148-106.6561.0044.57 B ATOM 7710 NH2 ARGB 344 -25.646-38.548-107.0261.0044.88 B

ATOM 7711 C ARG B 344 -23.389-36.621-99.375 1.0040.59 B

ATOM 77120 ARG B 344 -23.950-35.634-98.913 1.0039.89 B

ATOM 7713 N ILE B 345 -22.103-36.881-99.193 1.0040.09 B

ATOM 7714 CA ILE B 345 -21.239-36.004-98.4291.0039.84 B ATOM 7715 CB ILE B 345 -20.988-36.572-96.996 1.0039.20 B

ATOM 7716 CG2 ILE B 345 -19.737-35.954-96.382 1.0037.70 B

ATOM 7717 CGl ILE B 345 -22.212-36.327-96.105 1.0038.01 B

ATOM 7718 CDl BLE B 345 -22:082-36.915-94.7121.0035.06 B ATOM- 7719 C ILE B 345 -197912-35.890-99.161 1.0041.09 B

ATOM 7720 Q ILEB--345 -19:270-36.895-99.448 1.0040.89 B

ATOM 7721 N LYS B 346 -19.532-34.698-99.543 1.0042.17 B

ATOM 7722 CA LYS B 346 -18.241-34.408-100.084 1.0042.62 B

ATOM 7723 CB LYS-B 34^"6 -18.412 -35.216-100.9661.0043.14 B ATOM 7724 CG LYS B 346 -17.478-33.017-102.093 1.0041.36 B

ATOM 7725 CD LYS B 346 -17.645-31.-641-102.6441.0040.12 B

ATOM- 7726 CE LYS B 346 -16.90S-30.643-101-.809 1.0040.19 B

ATOM 7727 NZ LYS B 346 -17.817-29.758-101.0321.0040.18 B

ATOM 7728- C LYS B 346 -17.350-33.982-98.991 1.0042.92 B ATOM 7729 O LYSB^"34fr -1X640-33.042-98.3541.0042.56 B

ATOM 7730 N GLN B 347 -16.254-34.673-98.773 1.0043.33 B

ATOM 7731 CA GLN B 347 -15.298-34.289-97.739 1.0044.46 B

ATOM 7732 CB GLN B 347 -15.906-34.548-96.360 1.0044.80 B

ATOM 7733 CG GLN B 347 -15.047-34.105-95.183 1.0044.06 B ATOM 7734 CD GLNB 347 -15.372-34.878-93.9171.0042.39 B

ATOM 7735 OEl GLN B-347 -16.525-35.221-93.6691.0041.94 B

ATOM 7736 NE2JGLNB347 -14.356 -35.149 -93.10S 1.0040.77 B-

ATOM 7737 C GLN B 347 -13.99J -35.063 -97.863 1.0045.51 B

A-DOM- 7738^0 GLNB 347 -13.9S4 -36.289 -97.772- 1.0045.42 B ATOM 7739 N CYS-B 348- -12.890 -34341 -98:063 1.004.7.24 B

ATOM 7740 CA CYS B 348 -11.572.-34:958 -98rl93 WKT4&99 B

ATOM 774 r-C CYS B 348 -1-1.118 -35.454^~-96=818 1.0048.98 -B

ATOM 7742 O CYS B 348 -10.122-34.984-96.274 1.0050.46 B

ATOM 7743 CB CYS B 348 40.568-33.940-98.769 1.0050.32 B ATOM 7744 SG CYS B 348 -11.070-33.243-100.3891.0055.0S B

ATOM 7745 N THRB 349 -11.860-36.414-96.272 1.0048.36 B

ATOM 7746 CA THR B 349 -11.598-36.986-94.948 1.0048.03 B

ATOM 7747 CB THR B 349 -12.613-38.116-94.6241.0047.41 B

ATOM 7748 OGl THRB 349 -13.931-37.569-94.543 1.0047.68 B ATOM 7749 CG2 THRB 349 -12.281-38.780-93.305 1.0046.30 B

ATOM 7750 C THRB 349 -10.200-37.534-94.656 1.0048.19 B

ATOM 7751 O THRB 349 -9.771-38.512-952581.0047.84 B

ATOM 7752 N ALA B 350 -9.505-36.896-93715 1.0048.96 B ATOM 7753 CA ALA B 350 -8178 -37.33J6 -93.2841.0049.73 B

ATOM 7754 CB ALA B 350 -7.247-36.143-93.1101.0048.06 B

ATOM 7755 C ALA B 350 -8.410-38.042-91.9401.0050.47 B

ATOM 7756 O ALA B 350 -9.534-38.042-91.4271.0050.70 B

ATOM 7757 N VALB 351 -7.379 -38.650 -91.3621^".OO 50.83 B ATOM 7758 CA VAL B 351 -7.578-39.345-90.0941.0051.04 ^"B

ATOM 7759 CB VALB-351 -6.838-40.698=90.073 1.0050.5T B

ATOM 7760 CGl VAL B 351 -7.245-41.486-88.839 1.0049.37 B

ATOM 7761 CG2VALB351 -7.154-41.485-91.331 1.0050.03 B

ATOM 7762 C VAL B 351 -7.130 -3S.512-8S.8921.0052.13 B ATOM 7763 O VALB 351 -5.961 -38.551 -88.5O2 F.OO 52.31 B

ATOM 7764 N THR B 352 -8.080-37.765 -88-321 1005315 B

ATOM 7765 CA THRB 352 -7.861-36.899-87.15410052.83 B

ATOM 7766 CB THR B 352 -7.609-35.426-87.563 1.0053.24 B

ATOM 7767 OGl THR B 352 -6.632-35.375-88.6081.0053.73 B ATOM 7768 CG2 THR B 352 -7.100-34.606-86.3571.0054.03 B

ATOM 7769 C THRB 352 -9.127-36.911-86.3021.0052.77 B

ATOM 7770 O THR B 352 -10.203-57.244-86.7961:0032.27 B

ATOM 7771 N MET-B 353 -9.00$^36.541 =85.028-1.0052.71 B

ATOM 7772 CA -METB 353 -10.178 =36.513 -84.1651.0053.00 B ATOM 7773 CB MET B 353 -9.78^=36.292-82.702 1.00-54.58 B

ATOM 7774 CG MET B 35T -10.969-36.446-81.7421.0057.20- B

ATOM 7775 SD-MET B 353 -10.547 -36.21L -79.9981.0061.27 B

ATOM 7776 CE MET B 353 -10.489 -34τ369 -79.9051.0061.02 B

ATOM 7777 C MET B 353 -11.096-35.392-84.6361.0052.59 B ATOM 7778 O METB 353 -12.3O5 -35.578 -84.7471.0053.03 B

ATOM 7779 N ASP B 354 -10.564-34.230-84.89610052.62 B

ATOM 7780 CA ASP B 354 -11.327-33.143-85.480 1.0052.72 B

ATOM 7781 CB ASP B 354 -10.393-32.078-86.0341.0055.53 B

ATOM 7782 CG ASP B 354 -10.377-30.801-85.2321.0058.02 B ATOM 7783 ODl ASP B 354 -11.422-30.364-84.7541.0059.94 B

ATOM 7784 OD2 ASP B 354 -9.350-30.159-85.023 1.0058.55 B

ATOM 7785 C ASP B 354 -12.113-33.613-86.6201.0051.55 B

ATOM 77860 ASP B 354 -13.224-33.248-86.798 1.0050.70 B ATOM 7787 N GLNB 355 -11.470-34.367-8774621.0050.62 B^"

ATOM 7788 CA GLN B 355 -12.107 -34.880 -8&6701.00^~48.86 B-

ATOM 7789 CB GLN B 355 -11.112-35.730-89.471 1.0049.55 B

ATOM 7790 CG GLN B 355 -10.183-34.950-90.405 1.0048.73. B

ATOM 7791 CD GLN B 355^" -10.927 -34.3O4^" -91.5621.0047.85 B ATOM 7792 OEl GLNB 355 -11.744-34.944-92.225 IJOO 47.10 B

ATOM 7793 NE2 GLN B 355- -10.642-33.035-91:8141.0047.53 B

ATOM 7794 C GLN B 335 -13.331 -35.723 -8&319 1.004-7.48. B

ATOM 77950 GLNB 355 -14.432-35.457-88.811 1.0047.14 B

ATOM 7796 N LEUB 356 -13.130-36.738-87.4721.0045.22 -B ATOM 7797 CA LEU B 356 -14.206-37.628-87.045 1.0043.28 B

ATOM 7798 CB LEUB356 -13.715-38.570-85.9391.0042.93 B

ATOM 7799 CG LEU B 356 -14.746-39.379-85.1341.0042.21 B

ATOM 7800 CDl LEU B 356 -15.718-40.110-86.050 1.0041.77 B

ATOM 7801 CD2LEUB356 -14.010-40.360-84.2471.0039.91 B ATOM 7802 C LEU B 356 -15.403-36.827-86.5601.0043.03 B

ATOM 7803 O LEUB 356 -16.545-37.190-86.8391.00427-9- B

ATOM 7804- N SERB 357 -15,147-35.736-85.840 1.0043.00 Ε

ATOM 7805_CA SERB 357 -16.240-34.899 -8-5τ344-l .0.042.84 B

ATOM 7806 CB- SER B_357 -15=749 -337889 -84.2981.00-4.L32 IB ATOMl 7807-θ.α-SERB 357 -14.952 ~32.888>84.884 LOO 41.25 B-

ATOM 7808 C SER-B-3.57 -16.884-34.172-86:517170042.32 B

ATOM 78090 SER^"B^~357 -18.069-33.844-86.475 1.0042.22 B

ATOM 7810- N THR B 358 -16.099-33.922-87.563 1.0041.87 B

ATOM 7811 CA THR B-358 -16.630-33.269-88,7541.00-41.49 B ATOM 7812 CB THRB 358 -15.508-32.748-89.681 1.0042.55 B

ATOM 7813 OGl THRB 358 -14.920-31.571-89.1061.0043.06 B

ATOM 7814 CG2 THRB 358 -16.072-32.397-91.060 1.0043.37 B

ATOM 7815 C THRB 358 -17.484-34.290-89.5021.0040.22 B

ATOM 78160 THRB 358 -18.438-33.932-90.2081.0038.78 B ATOM 7817 N VAL B 359 -17.143-35.566-89.3321.0039.17 B

ATOM 7818 CA VAL B 359 -17.899-36.632-89.968 1.0037.65 B

ATOM 7819 CB VAL B 359 -17.164-37.988-89.8871.0036.86 B

ATOM 7820 CGl VAL B 359 -18.058-39.101-90.4091.0035,07 B ATOM 7-821 CG2VALB359 -15.888-37.933-90.7161.0036.04 B

ATOM 7822 C VAL B 339 -19.240-36.717-89.2561.0036.75 B

ATOM 7823 O VALB 359 -20.258-37.047-89.8641.0036.67 B

ATOM 7824 N HIS B 360 -19.248 -36.403 -87.9681.0035.66 B

ATOM 7825 CA HIS B 360 -20.495 -36.431 -87.2271.0035.59 B ATOM 7826 CB HIS B 360 -20.237 -36.430 -85.7161.0035.44 B

ATOM 7827 CG HIS B 360 -19.956-37.789 -85.151 hθO 37.13 B

ATOM 7828 CD2 HIS B 360 -20.748-38.649-84.4661.0037.32 B

ATOM 7829 NDl HIS B 360 -18.747-38.433-85.3161.0038.05 B

ATOM 7830 CEl HIS B 360 -18.809-39.630-54.7601.0038.18 B ATOM 7831 NE2 HIS B 360 -29:013 -39.786-84.2381.0037.11 B

ATOM 7832 C HIS B 360 -21.332-35.223-87.6271.0035.53 B

ATOM 7833 O HIS B 360 -22.529-35.353-87.8841.0034.02 B

ATOM 7834 N HIS B 361 -20.689-34.055-87.6921.0035.39 B

ATOM 7835 CA HTS B 361 -21.374-32.813-88.0651.0036.07 B ATOM 7836 CB HIS B 361 -20.407-31.611-88.083 1.0034.57 B

ATOM 7837 CG HIS B 361 -20 J80 -30.390 -88.7441.0033.94 B--

ATOM 7:838: CD2 HIS JB 361 =20.79=1 -29.879 -W.9861.0033.04 B

ATOM 7839 TvID-I HIS-B 361 -_21.94i =29.599 -88.152 LOO 34.05 B

ATOM 7840 CEl HIS B 361 -22r323 -28.659 -88.9991.0032÷43 Ε ATOM 784-1 NE2-HTS B 36i- -51.641 -28,809=-9θ:120- 1.0032.36 B

ATOM^" 7842 -C HIS B 361- -22.013 -32.936 -89.442 i"ΘO-37.15 -B

ATOM 7843 O HISB 361 -23.169 -32;533--89:64^"81-0036.55 B

ATOM 7844 N GLUB 362 -21.251 -33.481 -90.388, LOO 37.82 B-

ATOM 7845 CA GLUB 362 -21.750 -33.642 -9L741 1.0037.63 B ATOM 7846 CB GLUB 362 -20.620-34.071-92,6791,0037.48 B

ATOM 7847 CG GLU B 362 -19.564-32.988-92.9381.0038.67 B

ATOM 7848 CD GLU B 362 -20.144-31.688-93.4971.0040.27 B

ATOM 7849 OEl GLU B 362 -21.361-31.626-93.7621.0040.26 B

ATOM 7850 OE2 GLU B 362 -19.378-30.715-93.668 1.0041.69 B ATOM 7851 C GLU B 362 -22.904-34.634-91.7991.0036.65 B

ATOM 78520 GLUB 362 -23.937-34.353-92.403 1.0035.99 B

ATOM 7853 N MET B 363 -22.745-35.779-91.151 1.0036.10 B

ATOM 7854 CA MET B 363 -23.796-36.788-91.1591.0037.12 B ATOM 7855 -CB MET B 363 -23.300-38.061-90.481 1.0037.28 B

ATOM 7856 CG MET B 363 -24.150-39.268 -90.78T 1.0036.50 B

ATOM 7857 SD METB 363 -23.229-40.757-90.441 1.0039.20 B

ATOM 7858 CE METB 363 -22.155-40.863-91.871 1.0036.09 B

ATOM 7859 C METB 363 -25.069-36.289-90.4791.0037.07 B ATOM 7860 O METB 363 -26.184-36.695-90.8291.0035.55 B

ATOM 7861 N GLYB 364 -24.899 -35.405 -39.504 IrOO 36.86 B

ATOM 7862 CA GLY B 164 -26.045-34.863-88.8071.0036.56 B

ATOM 7863 C GLY B 364 -26.924-34.182-89.8221.0036.35 B

ATOM 7864 O GLYB 364 -28.153-34.198-89.7151.0036.56 B ATOM 7865 N JHIS B 365 -26.282-33.575-90.8171.0036.08 B

ATOM 7866 CA HIS B 365 -26.999-32.893-91.8881.0035.44 B

ATOM 7867 CB HISB 365 -26.015-32.204-92.8371.0035.41 B

ATOM 7868 CG fflS B 365 -25.542-30.869-92.3601.0034.10 B

ATOM 7869 CD2 HIS B 365 -24.295-30.384-92.161 1.003530 B ATOM 7870 NDl HIS B 365 -26.405 -29.838 -92.063 1.0033.27 B

ATOM 7871 CEl HIS B 365 -25.710-28.773-91.7041.0033.87 B

ATOM 7872 NErHIS B 365 -24.427-29.077-91.755 1.0035.56 B

ATOM 7873 C HIS B 365 -27.826 -33.9 L8 -92^6611.0034.95 B

ATOM 7874 O _-HIS B 365 -29.026 -33.729 -92.8651.00^~33.H B- ATOM^" 7875 N JLE R366 -27.176-35D04 -93^081 h0034:78 B

ATOM 7876 CA ILE B 366 -27:859-36,057 -93.8281.0054,88 B

ATOM 7877 GB JLE B 366 -26.951-37.287-94:083 1.0033.53 B

ATOM 7878 CG2 ELE B 366 =27.712 -35.331 -94.8771.0031.26 B

ATOM 7879 CGl ILE B 366 -25.691-36.871-94.8421.0033.82 B ATOM 7880 CDl ELE B 366 -25.963-36.164-96.153 1.0036.40 B

ATOM 7881 C ILE B 366 -29.076-36.535-93.055 1.0035.80 B

ATOM 78820 ILE B 366 -30.214-36.418-93.5261.0035.32 B

ATOM 7883 N GLNB 367 -28.832-37.069-91.863 1.0035.78 B

ATOM 7884 CA GLNB 367 -29.915-37.572-91.042 1.0035.89 B ATOM 7885 CB GLN B 367 -29.447-37.753-89.6021.0035.75 B

ATOM 7886 CG GLN B 367 -30.490-38.410-88.7371.0034.68 B

ATOM 7887 CD GLN B 367 -30.886-39.779-89.2541.0034.23 B

ATOM 7888 OEl GLNB 367 -32.067-40.108-89.3161.0033.60 B ATOM 7889 NE2 GLN B 367 -29.895-40.590-89.6131.0033.57 B

ATOM 7890 C GLNB 367 -31.108 -36.625-91.081 1.0036.31 B

ATOM 7891 O GLNB 367 -32.260-37.058-91.1421.0036.08 B

ATOM 7892 N TYRB 368 -30.827-35.327-91.061 1.0035.61 B

ATOM 7893 CA TYR B 368 -31.885-34.333-91.0721.0035.53 B ATOM 7894 CB TYRB 368 -31.286-32.945-90.8001.0033.33 B

ATOM 7895 CG TYR-B 368 -32.213-31.954-90.1171.0030.75 B

ATOM 7896 CDl TYR B 368- -31.701-30.867-89.4091.0030.09 B

ATOM 7897 CEl TYRB 368 -32.544-29.943-88.7851.0030.19 B

ATOM 7898 CD2 TYRB 368. -33.593-32.091-90.1861.0030.23 B ATOM 7899 CE2 TYR B 368 -34.444-31.171-89,5681.0031.20 B

ATOM 7900 CZ TYRB 368 -33.916-30.101-88.8701.0030.28 B

ATOM 7901 OH TYR B 368 -34.765-29.192-88.2741.0028.20 B

ATOM 7902 C TYRB 368 -32.595-34.389-92.4241.0036.63 B

ATOM 7903 O TYRB 368 -33.810-34.214-92.508 1.0037.60 B ATOM 7904 N TYRB 369 -31.830-34.655-93.4781.0037.29 B

ATOM 7905 CA TYRB 369 -32.382 -34.746 -94.8351.0038.81 B

ATOM 7906 CB TYRLB-369 -3-1.249 -34.866 -95.87210037.68τ B

ATOM 7907 CG TmB 369 -30.342 -33.654 -96.0271.0035.62 B

AT-ΘM 7908 CDl TYR-B-369 -29.005 -33Jtl4-_96r4001.0033.84 B ATOM 7909 CEl TYRB 369 -28.163-32.718-96,5771.0034.80 _B

ATOM- 7910-GD2:TYRB 369 -30.822 -321354 -95.83-7 hθθy6.28- B-

ATOM 7911 CE2 TYR-B 369 -29:987-3-1.247-96.0171.0036.72 B

ATOM 7912 CZ TYRB 369- -28.657-31.441-96.385 1.0036.26 B

ATOM 7913 OH TYRB 369 -27.819-30.364-96.5501.0035.15 B ATOM 7914 C TYRB 369 -33.289-35.982-94.948 1.0039.52 B

ATOM 7915 O TYRB 369 -34.400-35.924-95.4971.0039.48 B

ATOM 7916 N LEU B 370 -32.790-37.103-94.432 1.0039.34 B

ATOM 7917 CA LEU B 370 -33.522-38.361-94.455 1.0039.14 B

ATOM 7918 CB LEUB 370 -32.659-39.472-93.8521.0037.05 B ATOM 7919 CG LEU B 370 -31.326-39.734-94.559 1.0037.87 B

ATOM 7920 CDl LEUB 370 -30.421-40.607-93.7061.0036.65 B

ATOM 7921 CD2LEUB370 -31.595-40.390-95.8921.0037.66 B

ATOM 7922 C LEU B 370 -34.850-38.281-93.694 1.0040.34 B ATOM 7923 O LEUB 370 -35.824-38.923-94.080 1.0042.91 B

ATOM 7924 N GLNB 371 -34.895-37.492-92.6241.0040.39 B

ATOM 7925 CA GLN B 371 -36.099-37.377-91.8071.0039.90 B

ATOM 7926 CB GLN B 371 -35.737-36.891-90.402 1.0040.24 B

ATOM 7927 CG GLN B 371 -35:011-37.899-89.541 1.0039.24 B ATOM 7928 CD GLN B 371 -35.797 -39.179 -89.373 1.0038.72 B

ATOM 7929- OEl GLN B 371 -37.029-39.162-89.3381.0038.57 B

ATOM 7930 NE2 GLN-B 371 -35.088-40.298-89.2521.0037.67 B

ATOM 7931 C GLNB 371 -37.208-36.491-92.350 1.0040.74 B

ATOM 7932-0 GLN B 371 -38.372-36.704-92.020 LQO 40.15 B ATOM 7933 N TYRB 372 -36.869-35.487-93.155-1.0042.06 B

ATOM 7934 CA TYRB 372 -37.916-34.614-93.678 1.0043.42 B

ATOM 7935 CB TYRB 372 -37.697-33.153-93.2471.0044.77 B

ATOM 7936 CG TYRB 372 -36.402-32.500-93.6921.0047.30 B

ATOM 7937 CDl TYRB 372 -35.856-32.756-94.9521.0048.21 B ATOM 7938 CEl TYRB 372 -34J09 -32.099 -95.3941.0049.24 B

ATOM 7939- CD2 TYR B 372 -35.760-31.564-92.8751.0048.16 B

AT-OM 7940^' CE2 TYR B 372 -34.612 -30.897 -93306 1.0050.30 B

ATOM 7941 CZ TYR-B 372 -34.089-31.169-94.5701.0050.31 B

^"ATOM 7942 OH TYRB 372 -32.958 -30.511 -95,014 LOO 49.28 -B ATOM 7943 C TYRB 372_ -38.102-34.677-95.183 1.0043:97 B

ATOM 7944 O TYRB 372 -38^630-337737-95.783 1.0045.25 B

ATOM 7945 N LYS B 373 -37.660-35.773-95.7921.0043.70 B

ATOM 7946 CA LYS-B 373 -37.879-35.998-97.215 1.0043.23 B

ATOM 7947 CB- LYS B 373 -37.059 -37.195 -97.7001.0042.00 B ATOM 7948 CG LYS B 373 -37.527-38.531-97.148 1.0041.78 B

ATOM 7949 CD LYS B 373 -36.625-39.665-97.6061.0041.47 B

ATOM 7950 CE LYS B 373 -37.218-41.019-97.2541.0041.29 B

ATOM 7951 NZ LYS B 373 -36.506-42.133-97.940 1.0042.46 B

ATOM 7952 C LYS B 373 -39.358-36.225-97.502 1.0043.81 B ATOM 7953 O LYS B 373 -39.780-36.253-98.658 1.0042.96 B

ATOM 7954 N ASP B 374 -40.125-36.383-96.418 1.0044.89 B

ATOM 7955 CA ASP B 374 -41.543-36.698-96.5471.0045.72 B

ATOM 7956 CB ASPB 374 -42.072 -37.30T-95.2471.0050.29 B ATOM 7957 CG A-SP-β-374 -4-1.255 -36.89S -94.0371.0054.94 B

ATOM 7958 ODl ASP B 374 -40.274 -37.601 -33.715 1.0057.98 B

ATOM 7959 OD2 ASP B 374 -41.517-35.890-93.349 1.0056.59 B

ATOM 7960 C ASP B 374 -42.348 -35.454 -96.907 1.0044.57 B

ATOM 7961 O ASP"B374 -43.542^35.537-97.1941.0044.78 B ATOM 7962 N LEU B 375 -41. TOO -34.304 -96.9091.0043.75 B

ATOM 7963 CA LEU B 375 -42.392-33-022-96.9671.0043.18 B

ATOM 7964 CB-LEUB 375 -41.822-32.059-95.924 1.0043.93 B

ATOM 7965 CG LEU B 375 -41.922 -32.502 -94.4641.0043.40 B

ATOM 7966 CDl LEU B-375 -41.219-31.510-93.551 1.0043.20 B ATOM 7967 CD2 LEU B 3-75 -43376-32.677-94.053 1.0042.22 B

ATOM 7968 C LEUB 375 -42.295-32.406-98.358 1.0042.31 B

ATOM 79690 LEUB 375 -41.587-32.917-99.2261.0041.25 B

ATOM 7970 N PRO B 376 -43.011-31.306-98.564 1.0041.93 B

ATOM 7971 CD PRO B 376 -4£143 -30.820 -97.757 1.0041.84 B ATOM 7972 CA PRO B 376 -42.923-30.555-99.8141.0041.94 B

ATOM 7973 CB P-ROB 376 -43.972-29.460-99.635 1.0041.05 B

ATOM 7974 CG PRO B 376- -44.996 -30.1 OS ^98.788 1.0039.97 B

ATOM- 7975 C PRΘ"B-θ76 -41.513-29.976-99:9-101.0042.83 B

ATOM 7976 Or-PRO K376 -40.923 -29.575 -98.9041.00-43.52 B - ATOM 7977 N VAlTB 377 -40.971-29:951-101.118 1.0043.42 B

ATOM 7978^" CA VALB 377 -39.637-29.417-1.01.352 1.0042.85 B

ATOM 7979 CB VALB 377 -39.457-29.102-102.8671.0042.25 B

ATOM 7980 CGl VAL B 377 -3^"8^'.385 -28.066- L03.081 1.0040.79 B

ATOM 7981 CG2VALB377 -39.102-30.375-103.605 1.0041.25 B ATOM 7982 C VAL B 377 -39.391-28.159-100.5121.0042.64 B

ATOM 7983 O VAL B 377 -38.471-28.110-99.6971.0041.88 B

ATOM 7984 N SERB 378 -40.240-27.158-100.710 1.0042.92 B

ATOM 7985 CA SERB 378 -40.134-25.881-100.0171.0043.99 B

ATOM 7986 CB SERB 378 -41.408-25.071-100.243 1.0044.82 B 7/080400 ₃₂₁

ATOM 7987 OG SERB 378 -41.825-25.139-101.593 1.0046.48 B

ATOM 7988 C SER B 378 -39.865-25.956-98.5151.0044.48 B

ATOM 79890 SERB 378 -39.292-25.021-97.9481.0045.94 B

ATOM 7990 N LEUB 379 -40.270-27.050-97.8671.0044.44 B ATOM 7991 CA LEUB 379 -40.092-27.1-87-9674171.00-43.62 B

ATOM 7992 CB LEUB 379 -41.403-27.634-95.7651.0042.99 B

ATOM 7993 CG LEU B 379 -42.676-26.839-96.0581.0042.39 B ATOM 7994 CDl LEU B 379 -43.833-27.486-95.330 1.0042.42 B ATOM 7995^" CD2 LEU B 379 -42.520-25.399-95.6191.0042.42 B ATOM 7996 C LEU B 379 -38.978-28.123-95.953 1.0043.61 B

ATOM 7997 O LEU B 379 -38.704-28.210-94.7591.00-43.23 B

ATOM 7998 N ARGB 380 -3.8.346- -2O33 -96.8821.0044.36 B

ATOM 7999 CA ARG B 380 -37.268-29.750-96.515 1.0045.51 B

ATOM 8000 CB ARG B 380 -36.940-30.680-97,690.1.0046.28 -B ATOM 8001 CG ARG B 380 -38.131 -31.446 -9S.259 1.0046.60 B

ATOM 8002 CD ARG B 380 -37.686-32.192-99.5061.0049.86 B ATOM 8003 NE ARGB 380 -38.767-32.890-100.205 1.0049.98 B- ATOM 8004 CZ ARGB 380 -38.577-33.672-101.2671.0049.40 B ATOM 8005 NHl ARGB 380 -37.355-33.858-101.7561.0048.74 B ATOM 8006 NH2 ARG B 380 -39.607-34.280-101.8341.0050.58 B

ATOM 8007 C ARG B 350 -36.024 ~28.949^~-96.103 IJOO 45.62^" -B:

ATOM- 8008 O ARGB 380 -34.983 -28.987 -96.7M T.Ofl 45.57 B

ATOM 8009 N ARG-B 381 -36Λ 8-7-28.225 -94?9821. OD 46.21 B

ATOM SQlO CA-ARG B^~3S1 -35.227 -27-299 -94:4301.0046.18 B ATQM 8011 CB ARG-B 381 -35.667 -25.929 -94:840 L0047.9Θ B-

ATOMr -801-2-CG ARG-B 381 -35.321-25.611-96.1681.0051.14 B

ATOM^" 8OB CD ARGB 381- -36.101 -24.582-96:765 L.00..55.54 B

ATOM 8014 NE ARGB 3Sl -35-286-23.970-97.775 1.0060736 B

ATOM -8015 CZ ARGB 381 -35.74.0-23.491-98.9061.0063.00 B ATOM 8016 NHl ARGB 381^" -37.029-23.582-99.2121.0065.04 B ATOM 8017 NH2 ARG B 381 -34.903-22.881-99.715 1.0063.70 B

ATOM 8018 C ARGB 381 -35.136-27.353-92.9041.0044.61 B

ATOM 8019 O ARGB 381 -36.087-27.655-92.3041.0045.51 B

ATOM 8020 N GLYB 382 -34.039-27.029-92.2801.0042.73 B ATOM 8021 CA GLY B 382 -33.985-27.060-90.826 1.0039.59 B

ATOM 8022 C GLYB 382 -34.989-26.103-90.2101.0037.27 B

ATOM 8023 O GLYB 382 -35.435-25.175-90.883 1.0036.50 B

ATOM 8024 N ALAB 383 -35.358 -26.326 -8S.9491.0035.17 B ATOM 8025 GA ALA B 383 -36.317-25.453-88.2771.0033.93 B

ATOM 8026 CB ALA B 383 -36.274-25:686-86.773 LOG 34.84 B-

ATOM 8027 C ALAB 383 -35.903-24.029-88.611 1.0033.19 B

ATOM 8028 O ALAB 383 -36.733-23.155-88.8621.0033.18 B

ATOM 8029 N ASNB 384 =34.592 -23.824-88.586 l.Oσ 32.47 B ATOM 8030 CA ASNB 384 -33.945-22.572-88.9391.0031.49 B

ATOM 8031 CB ASN B 384 -34.046-21.508-87.823 1.0031.83 B

ATOM 8032 CG ASNB 384 -33.178-21.805-86.600 1.00-31.57 B

ATOM 8033 ODl ASN B 384 -31.983-22.084-86.7061.0031.17 B

ATOM 8034 ND2 ASN B 384 -33.785 -21.703 -85.4241.0029.03 B ATOM 8035 C ASN B 384 -32.515 -23.025 -89.1-991.0030.83 B

ATOM 8036 O ASNB 384 -32.057-24.012-88.6101.0029.95 B

ATOM 8037 N PRO B 385 -31.795-22.327-90.0891.0030.19 B

ATOM 8038 CD PRO B 385 -32.129-20.975-90.571 1.0028.82 B

ATOM 8039 CA PRO B 385 -30.409 -22.682 -90.433 1.0030.78 B ATOM 8040 CB PRO B 385 -29.851-21.380-90.993 1.0029.22 B

ATOM 8041 CG PRO B 385 -31.063-20.736-91.605 1.0029.85 B

ATOM 8042 C PRO-B 385 -29v567 -23.235 -89:278 1,0031.97 B

ATOM- 8043 O PRO B 3-85 -28.767 -24.158 -89.4J61 1.0033TO9 B

ATOM 8044 N GLY B 386 -29.756_-22.67t-88.0901.0032.06 B ATΘM 8045 CA^" GLY B-386 -29.003-23.112-86:9371.0031.34 B

^"ATOM 8046 C GLY B 386 -29:221-24:573-86.613 1.0032.26 ~B

ATOM 8047 O GLY B 386 -28O55 -25.322 -86.512^" h0033.49^" B-

ATOM 8048 N PHE B 387 -30.480-24.979-86.449 1.0031.80 B

ATΘM 8049 CA PHEB 387 -30.811-26.361-86.120 1.0030.19 B ATOM 8050 CB PHE B 387 -32.277 -26τ644 -86.4071.0030.94 B

ATOM 8051 CG PHE B 387 -33.211-26.138-85.3571.0031.33 B

ATOM 8052 CDl PHE B 387 -33.280 -24.779 -85.0561.0031.56 B

ATOM 8053 CD2PHEB387 -34.049-27.019-84.6781.0030.81 B

ATOM 8054 CEl PHE B 387 -34.180-24.297-84.0901.0031.84 B ATOM 8055 CE2PHEB387 -34.950-26.552-83.715 1.0032.51 B

ATOM 8056 CZ PHEB 387 -35.014-25.182-83.4221.0032.19 B

ATOM 8057 C PHE B 387 -29.979-27.350-86.9001.0029.69 B

ATOM 8058 O PHE B 387 -29.555-28.369-86.3641.0029.89 B ATOM^" 8059 N HIS B 388 -29.749-27.042-88.1701.0029.45 B

ATOM 8060 CA HIS B 388 -28:985^~-27.909 -89.048 1.0029.14 B

ATOM 8061 CB HIS B 388 -28.997-27.340-90.4671.0030.29 B

ATOM 8062 CG HIS B 388 -29.666-28.234-91.4671.0031.65 B

ATOM 8063 CD2 HIS B 388 -30.875 -28.148 -92.070 L00^~32.74 B ATOM 8064 NDl HIS B 388 -29.102-29.413-91.9101.0032.33 B

ATOM 8065 CEl HIS B 388 -29.936 -30.016 -92.738- 1.0032.85 B

ATOM 8066 NE2 HIS B 388 -31.020-29.270-92.8521.0O33.89 B

ATOM 8067 C HIS B 388 -27.554-28.143-88.5951.0029.12 B

ATOM 8068 O HIS B 388 -27.150-29.273-88.3401.0028.63 B ATOM 8069 N GLU B 389 -26.782 -27.072 -88.4961.Θ031.06 B

ATOM 8070 CA GLU B 389 -25.389-27.198-88.085 1.0033.28 B

ATOM 8071 CB GLUB 389 -24717-25.816-88.055 1.0033.98 B

ATOM 8072 CG GLU B 389 -24.884--24.964 -89.313 LOO 34.34 B

ATOM 8073 CD GLU B 389 -24.489 -25.695 -90.5891.0034.65 B ATOM 8074 OEl GLUB 389 -23.594-26.564-90.5251.0033.95 B

ATOM 8075 OE2GLUB389 -25.O70 -25.388 -91.6571.0034.05 B

ATOM 8076 C GLU-B 389 -25.292 -27.846 -86,699 1.0033,87 B

ATOM 8077 θ GLUB 389 -24.255-28:405 -86.32R- 1.00-34.67 B-

ATOM 8078 N ALA-B 390 =26.387-27^74 -85.948 1.0033.59 B ATOM 8079 CA ALABJ90 —26.451 -2S3Q5 -84.593 1:00-33.27 B

ATOM 808Θ-CB ALA-B3P0 -27.590-27.629^~ -83.841 1.0033:24 B

ATOM 8081 C ALA B 390 -26.580-29.825-84.474170033742 B-

ATOM 8082 O ALA B 39-0 -25.790-30.463-83.77-5 1.0034.03 B

ATOM 8083 N DLE B 391 -27.571-30.406-85.141 1.0032.15 B ATOM 8084 CA ILE B 391 -27.777-31.849-85.070 1.0031.57 B

ATOM 8085 CB ILE B 391 -28.489 -32.370 _r86.331 1.0029.33 B

ATOM 8086 CG2 ILE B 391 -28.648-33.872-86.2661.0027.16 B

ATOM 8087 CGl ILE B 391 -29.856 -31.707 -86.4561.0028.54 B

ATOM 8088 CDl ILE B 391 -30.742-31.900-85.2621.0029.51 B ATOM 8089 C ILE B 391 -26.500-32.668-84.8571.0032.49 B

ATOM 8090 O ILE B 391 -26.333-33.314-83.8271.0032.78 B

ATOM 8091 N GLYB 392 -25.592-32.620-85.8191.0033.11 B

ATOM 8092 CA GLY B 392 -24.371 -33.394 -85.7071.0033.77 B ATOM 8093- C GLYB-392 -23.514-33.170-84.482 1.0034.47 B

ATOM 8094 O GLYB 392 -22.998-34.129-83.9201.0035.20 B

ATOM 8095 N ASP B 393 -23.350-31.916-84.0741.0035.58 B

ATOM 8096 CA ASP B 393 -22.527-31.577-82.9081.0036.43 B

ATOM 8097 CB ASP B 393 -22.491 -J0.048 -82.696 1.0039.94^" B ATOM 8098 CG ASP B 393 -21.460-29.333-83.598 1.0042.21 B

ATOM- 8099 ODl ASP B 393 -21.397 -29.628 -84.815 1.0042.90 B

ATOM 8100 OD2 ASP B 393 -20.718,-28.457-83.090 1.0043.85 B

ATOM 8101 C ASP B 393 -23.016-32.258-81.635 1.0034.84 B

ATOM 8102 O ASPB 393 -22.223-32.833-80.8861.0033.97 B ATOM 8103 N VAL B 394 -24,322-32.193-81.398 1.0033.65 B

ATOM 8-104 CA VAX B 394 -24.921 -32.796 -80.208 1.0033.15 B

ATOM 8105 CB VAL B 394 -26.464-32.812-80.3061.003L92 B

ATOM 8106 CGl VALB 394 -27.064-33.079-78.953- 1.0Θ 31.72 B

ATOM 8107 CG2 VAL B 394 -26.967-31.490-80.8401.0031.85 B ATOM 8108 C VAL-B 394 -24.415-34.227-80.018 1.0033.51 B

ATOM 8109 O VAL B 394 -23.945-34.600-78.940 1.00-34.14 B

ATOM .8110 N LEU B 395 -24.503 -35.03Θ-8LΘ70 1.0033.15 B

ATOM 8111 CA LEUB 395 -24.040 -36:406 -80.989 LOO 34-.B^" B

ATOM 8-112- CB LEUB 395- -34=409 -37.167 -82.2641.00^2.81 Ef ATOM 8113 CG LEU B-395 -25.862 -3-7.654 -82.299.1.G0-33.22 B

ATΘM 8114 CDi LEU B 395 -26.821-36.483-82.033 1.0032.12 B

ATOM 8115 CD2 LEU B-395 -26.149-38.320-83_^6421.0032.25 B

ATOM 8116- C LEU B 395 -22.542-36.490-80.751 1.0034.72 B

ATOM 8117 O LEU B 395 -22.074-37.346-80.0121.0035.86 B ATOM 8118 N ALAB 396 -21.789-35.595-81.373 1.0034.95 B

ATOM 8119 CA ALAB 396 -20.341-35.600-81.2241.0035.37 B

ATOM 8120 CB ALA B 396 -19.712-34.620-82.1991.0036.51 B

ATOM 8121 C ALA B 396 -19.944-35.253-79.801 1.0035.97 B

ATOM 8122 O ALA B 396 -18.858-35.617-79.3461.0035.69 B ATOM 8123 N LEUB 397 -20.816-34.539-79.0961.0036.39 B

ATOM 8124 CA LEU B 397 -20.522-34.190-77.713 1.0035.92 B

ATOM 8125 CB LEUB 397 -21.630-33.302-77.131 1.0034.39 B

ATOM 8126 CG LEU B 397 -21.535-31.842-77.5921.0033.54 B ATOM 8127 CDl LEUB 397 -22.824-31.108-77.29.01.0033.84 B

ATOM 8128 CD2 LEU B 397 -20.350-31.162-76.921 k0030.72 B

ATOM 8129 C LEU B 397 -20.375-35.488-76.923 1.0035.53 B

ATOM 8130 O LEU B 397 -19.426-35.633-76.1481.0034.80 B

ATOM 8131 N SERB 398 -21.296-36.433-77.1521.0034.92 B ATOM 8132 CA SERB 398. -21.274 -37.742 -76.4821.0034.20 B

ATOM 8133- CB SERB 398 -22.563-38.527-76.7601.0033.26 B

ATOM^" -8134 OG SERB 398 -23.706 -37.829-76.305 1.0033.23 B

ATOM 8135 C SERB 398 -20.082-38.592-76.9171.0034.17 B

ATOM 81360 SERB 398 -19.536-39.339-76.123 l.θfl 35.15 B ATOM 8137 N VAL B 399 -19.682-38.485-78.176 1.0.033.74 B

ATOM 8138 CA VAL B 399 -1-8.553 -39.259 -78:665 1.0034.65 B

ATOM 8139 CB VALB-399 -18.480-39.236-80.210 IJOO 34.96 B

ATOM 8140 CGl VAL B 399 -17.320 -40.091 -80.7001.0032.26 B

ATOM 8141 CG2 VAL B 399 -19.783-39.730-80.793 1.0034.26 B ATOM 8142 C VAL B 399 -17.255 -38.691 -78J051.0036.11 B

ATOM- 8-143- O VALJB 399 -16.297 -39.426-77.890 LOO 36.74 B

ATOM 81441ST .SER B 400 -17,229-37.380-77:8771:0.0:37.15 B.

ATOM 8145 CA SERB 400 -M.050 -36.701 -77.337 LOO 38.24 B

ATOM 8146 -€BL SERB 400 -16.-26-2 -35.185 -77.342 Jtθθ-39J9^" B - ATOM 8147 OG SERB 400 -16.483 -34.703^' -78.655 IJ)G -42J21 B

ATOM~-81-48-C SERB-40O -15.717-37.137-75.911 1.0038^4 B-

ATOM 8149- O SER B 400 -14.568 -37.034 -75.4851.00.39.06 B

ATOM.- 8150 N THRB 401 -16.722-3-7.620-75.1791.0038.97 B

ATOM 8151 CA THRB 401 -16.541-38.051-73.795 1.0038.98 B ATOM 8152 CB THRB 401 -17.877-38.405-73.131 1.0039.57 B

ATOM 8153 OGl THRB 401 -18.449-39.534-73.7931.0039.97 B

ATOM 8154 CG2 THRB 401 -18.840-37.236-73.2101.0040.49 B

ATOM 8155 C THRB 401 -15.613-39.250-73.6561.0039.07 B

ATOM 81560 THRB 401 -15.698-40.207-74.425 1.0037.94 B ATOM 8157 N PRO B 402 -14.709-39.202-72.661 1.0039.41 B

ATOM 8158 CD PRO B 402 -14.455-38.015-71.8221.0039.06 B

ATOM 8159 CA PRO B 402 -13.731-40.246-72.365 1.0039.54- B

ATOM 8160 CB^ PRO B 402 -13.013-39.698-71.145 1.0039.38 B AT-ΘM 8T61 CG= PRO B 402 -13.025-38.228-71.403 1.0038.43 B

ATOM 8162 C PRO B 402 -14.362 -4L594 -72.103 1.0040.96 B

ATOM 8163 O PRO B 402 -13.743-42.622-72.3361.0040.91 B

ATOM 8164 N ALA B 403 -15.595-41.585-71.6121.0043.30 B ATOM 8165 CA ALAB 403 -16312 -42.826 -71.323 1.0045.67 B ATOM 8166 CB ALAB 403 -17.517-42.537-70.419 1.0044.99 B

ATΘM 8167 C ALAB4QΪ -16.773-43.535-72.6041.0047.34 B

ATOM 8168 O ALAB 403 -Ϊ6.868 -44.761- -72.642 1.0049.23 B-

ATOM 8169 N HIS B 404 -17.063-42.764-73.6491.0048.15 B

ATOM -8170 CA fflS B 404 -17.515-43.330-74.918 1.0048.01 B. ATOM^" 8-171 CB HISB 4Θ4 -1-8.331-42.298-75.7001.0047:11 B

ATOM 8172 CG HIS B 404 -18.981-42.852 -76.9291.0046.98 B

ATOM 8173- CD2 fflS B 404 -18.510-43.020-78.185 1.0046.64 B-

ATOM 8174 NDl HIS B 404 -20-265-43.356-76.9281.0046.57 B

ATOM 8175 CEl HIS B 404 -20.556-43.810-78.133 1.0045,50 B ATOM 8176 NE2 HIS B 404 -19.508 -43.621- -78.9151.0046.60 B

-ATOM 8177 C HIS^~B 404^" -16.320-43-.773 -75.7651.0048.78 B

ATOM -8Ϊ78VO HIS B÷404 -16.355-44,815-76,4241.0048.10 B

ATOM -8179 Η LEUB 405 -.157262-42.970-75.7461.0050:71 B

AT-OM MSQ CA LEU B 405 -14.025 -43.T326--7-6.430 -1.0052.11 B ATOM^-8-l-8-rCB-LEUB 405- -12.935-42.293-76.140 1.0052.18 B

-ATOM- 81-82 CG LEU B 405 -13.247-40,854-76.5571.0-852.22 B^" ATOM^"8-183_CD-1LEUB4O5- -11.996-39.991-76.492 1.0052τ69 B ATOM 8184 CD2 LEUB 405 -13.857-40.817-77.950 1.00-51.58 B

ATOM 8185 C LEUB465 -13.558-44.717-76.013 1.0053.38 B ATOM 81860 LEU B 405 -13.453-45.621-76.841 1.0055.04 B

ATOM 8187 N HIS B 406 -13.284-44.880-74.723 1.0054.04 B

ATOM 8188 CA HIS B 406 -12.971-46.190-74.163 1.0054.43 B

ATOM 8189 CB HIS B 406 -12.870-46.110-72.6381.0055.37 B

ATOM 8190 CG HIS B 406 -12.913-47.444-71.9591.0056.18 B ATOM 8191 CD2HISB406 -11.925-48.220-71.4541.0055.80 B

ATOM 8192 NDl fflS B 406 -14.089-48.128-71.7361.0055.96 B

ATOM 8193 CEl HIS B 406 -13.823-49.268-71.123 1.0055.14 B

ATOM 8194 NE2HISB406 -12.517-49.348-70.9401.0055.59 B ATOM 8195 C HIS. B 406 -14.910-47.232-74.565 1.005421 B

ATOM 8196 O HIS B 406 -13.664-48.323-75.0191.00,55.14 B

ATOM 8197 N LYS B 407 -15.282-46.889-74.3951.0053.11 B

ATOM 8198 CA LYS B 407 -16.372-47.792-74.7461.0052.89 B

ATOM 8199 CB LYS B.407 -17.725-47.137-74.4591.0052.30 B ATOM 8200 CG LYS B 407 -18.911 -47.887^~-75.0391.0052.12 B

ATOM 8201 CD LYS^~B 407 -20.223 -47.202 -74_^687 L00^~54.02 B

ATOM 8202 CE XYS B 407 -20.444-47.172-73.183 1.0054.97 B

ATOM 8203 NZ LYS B 407 -21.822-46.730-72.833 1.0056.26 B

ATOM 8204 C LYS B 407 -16.291- -48.207 -76.211 1.0053.47 B ATOM 8205 O LYS B 407 -16.941-49.164=76.632 1.0054.08 B

ATOM 8206 N ILE B 408 -15.489-47.481-76.983 1.0053.98 B

ATOM 8207 CA ILE B 408 -14.986 -47.9S5 -78.256 1.0054.61 B

ATOM 8208 CB DLE B 408 -15.451-47.084-79.4141.0053.82 B

ATOM 8209 CG2 ILE B 408 -16.880-46.612-79.181 1.0053.15 B ATOM 8210 CGl ELE B 408 -14.508-45.890-79.5741.0052.78 B

ATOM 8211 CDl DLEB 4OS -15.:Θ66 -44.594 -79.0290.0053.05- B

ATOM 8212 C DLE B 408 -13.464-48:084-78.2481.00-56.53 B

ATOM 8213.O D^EB-408 -12:84-7-48211 -77.191 1.00.57.22 -B

ATOM 82T4 N GLY B 409 -12:866-48.026-79.434 1.0058.73 B- ATOM 8215 CA GLY B 409 -ir.434--47.826 -79.5561.0062.18 B

ATOM 8216 C GLYB409- -M),943 -46.642 -78.7481.0064.5-7 B

ATOM 8217 O GLYB 409 -11:693-45.201-78.488 1.0066.33 B

ATOM 821:8^" N ALAB 410 -9.676-46.689-783501.0065:87 B

ATOM 8219 CA ALA B 410 -8.811 -45.516-78.406 IJOO 66.73 B ATOM 8220 CB ALA B 410 -9.148-44.667-79.621 1.0066.14 B

ATOM 8221 C ALA B 410 -8.921-44.689-77.1291.0066.79 B

ATOM 82220 ALAB 410 -8.393-43.580-77.0491.0067.27 B

ATOM 8223 N LEUB 411 -9.610-45.236-76.133 1.0067.24 B

ATOM 8224 CA LEU B 411 -9.194-45.090-74.7421.0067.94 B ATOM 8225 CB LEUB 411 -10.087-44.068-74.0351.0067.15 B

ATOM 8226 CG LEU B 411 -9.580-42.628-73.9351.0066.58 B

ATOM 8227 CDl LEUB 411 -10.102-41.970-72.6671.0066.28 B

ATOM 8228 CD2 LEU B 411 -8.062 -42.587 -73.981 1.0065.89 B ^" ATOM 8229 C LEU B 4-1-1 -9.324 -46.43T-74.042 1,00-68.71 _B

ATOM 8230 O LEUB 411 -10.393 -47.048 -74.06S- 1.0069.14 B

ATOM 8231 N ALAB 412 -8.249-46.905-73.4141.0068.64 B

ATOM 8232 CA ALA B 412 -8.349-48.126-72.6491.0068.61 B

ATOM 8233 CB ALA B 412 -7.290 -49.075 -73.0421.0067.36- B ATOM 8234 C ALA B 412 -8.272-47.858-71.1871.0069.11 B

ATOM 8235 O ALAB^~412 -8.622-48.705-70.398 1.0069.97 B

ATOM 8236 N ALAB 413 -7.754 -46.677 -70:857 LGO 68.76 B

ATOM 8237 CA ALA B 413 -7.698-46.082-69.524 1.0067.38 B

ATOM 8238 CB ALA B 413 -6.258 -45.660 -69.218 1.00-66.70 B ATOM 8239 -C ALA B 413 -8.643-44.896-69.288 1,0066.59 -B

ATOM 8240 O ALA B 413 -8.304-43.757-69.6061.0067.28 B

ATOM 8241 N VAL B 414 -9.823-45.172-68.7291.0065.48 B

ATOM 8242 CA VAL B 414 -10.807-44.112-68.403 1.0064.80 B

ATOM 8243 CB VAL B 414 -12.281-44.640-68.415 1.0064.22 B ATOM 8244 CGl VAL B 414 -13.222-43.599-69.034 1.0062.37 B

ATOM 8245 CG2VALB414 -12.357-45.959 -69.140 LOO 63.93 B

ATOM 8246 C VAL B 414 -1ΪL496-43.646 -66.959 1.0064.86: B

ATOM- 8247-O VAL B 414 -10.886 -443Θ4--65.986 1.0064τ66 B;

ATOM -8248 N THELB 415 -9.800-42.520-66.841 1.0064.327 B - ATOM 8-249 €A- THRB 415 -9τ240 -42Λ95 -65.5.63 1.00-6-4.07 B

ATOM 8250 CB T^R=B^'415 -8^39-40.791-65.733 1.00.63.36- B

ATOM- 8251^" OGlTHR-B 415 -8.966 -4tD:043 -66.8351.0063:14 ,B

ATOM 8252 CG2 THR B 415 -7.013-41.095-66.1671.0062.11 B

ATOM 8253 C THRB 415 -10.334 -41.906- -64.5171.0064.21 B ATOM 82540 THRB 415 -10.311-42.537-63.461 1.0065.14 B

ATOM 8255 N ASP B 416 -11.223-40.998-64.8471.0063.16 B

ATOM 8256 CA ASP B 416 -12.151-40.480-63.9041.0063.11 B

ATOM 8257 CB ASP B 416 -13.040-41.589-63.4391.0065.27 B

ATOM 8258 CG ASP B 416 -14.316-41.110-62.841 1.0067.45 B ATOM 8259 ODl ASP B 416 -14.241-40.601-61.718 1.0068.93 B

ATOM 8260 OD2 ASP B 416 -15.441-41.228-63.381 1.0067.80 B

ATOM 8261 C ASPB 416 -11.473-39.740-62.7741.0061.63 B

ATOM 8262 O ASP B 416 -11.662 -40.055 -61.6 IS 1.0060.43 B

ATOM 8263 N ASP B 4-17 -10.720-38.694-63.153 1.0050.27 B

ATOM 8264 CA ASFB 417 -9.953-37.866-62.230 1.0057.78 B

ATOM 8265 CB ASP B 417 -8.592-37.512-62.833 1.0058.92 B

ATOM 8266 CG ASP B 417 -7.524-37.303-61.7771.0061.40 B

ATOM 8267 ODl ASP B 417 -7.883-37:020-60.615 1.0063.58 B

ATOM 8268 OD2 ASP B 417 -6.303-37.402-62.0161.0063.21 B

ATOM 8269 C ASP B 417 -10.713,-36.594 -61.870- 1.0055.92 B

ATOM 8270 O ASP B 41-7 -11.852-36.398-62.295 1.0055.91^" B

ATOM 8271 N THRB 418 -10.076-35.732-61.0841.0053.72 B

ATOM 8272 CA THRB 418 -10387-34.292-61.103 1.0051.67 B

ATOM 8273 CB^" THRB 418 -10.082-33.592-59.757 LOO 51.43 B

ATOM -8274 OGl THRB 418 -11.235 -33.652 --58.9161.0052.17 B

ATOM 8275 CG2THRB418 -9.7L3 -32.117 -59.981 1.0050.49 B

ATOM 8276 C THRB 418 -9.606-33-539-62.1591.0050.69 B

ATOM 8277 O THRB 418 -10.177-32.833-62.9861.0049.81 B

ATOM 8278 N GLU B 419 -8.289-33.675-62.0991.0049.56 B

ATOM 8279 CA GLU B 419 -7.419-32.996-63.0371.0047.45 B

ATOM- 8280 CB GLU B 419 -5.957-33.303-62.715 1.0047.42 B

ATOM 8281 CG-GLTJ B 419 -5.6G8 -33.106 -6 L2521.0049.07 B

ATOM- 8282 CD GLU B 41-9- -4.125 -32.869 -.61.030 l.θθ-49.88 B

ATOM -S283 ΘE1 GLUB 419 -33-10 -33,424 -6-1.8071.0049r70 B-

ATOM 8284 OE2 GLU B 419 -3.776-32.139-60-70721.005033 B

ATOM 8285 C GLU B 415 -7.728-33,386 -64.469- 1.0045.96 -B

ATOM 8286 O GLU B 419 -7^15-32.523-65.3361.0045.85 B

ATOM 8287 N- SERB 420 -7.912-34.680-64.7181.004439 B

ATOM 8288 CA SER B 420 -8.190-35.149-66.071 1.0042.54 B

ATOM 8289 CB SERB 420 -8.109-36.669-66.1451.0043.58 B

ATOM 8290 OG SER B 420 -9.167-37.253-65.4171.0048.67 B

ATOM 8291 C SER B 420 -9.540-34.687-66.5941.0040.79 B

ATOM 8292 O SERB 420 -9.792-34.762-67.791 1.0041.97 B _33Q

ATOM 8293 N ASP B 421 -10.408-34.213-65.708 1.0039.02 B

ATOM 8294 CA ASP B 421 -11.716-33.720-66.125 1.0037.98 B

ATOM 8295 CB ASP B 421 -12.710-33.800-64.9641.0038.69 B

ATOM 8296 CG ASP B 421 -14.167-33.683-65.4151.0041.32 B ATOM 8297 -ODl ASP B 421 -15.049 -33.502 -64.5S1 1.0043.38 B

ATOM 8298 OD2 ASP B 421 -14.452 -33.784 -66.625 1.0042.79 B

ATOM 8299 C ASP B 421 -11.529-32.263-66.572 1.0037.76 B

ATOM 8300 O ASP B 421 -12.221-31.769-67.4671.0038.65 B

ATOM 8301 N ILE B 422 -10.583-31.574-65.9401.0036.46 B ATOM 8302 CA ILE B 422 -10.283 -30.188 -66.291 1.0034-58 B

ATOM 8303 CB ILEB 422 -9.232-29.571-65.3301.0034.16 B

ATOM 8304 CG2 ILE_B 422 -8.661 -28.285 -65.923 1.0033.96 B

ATOM 8305 CGl ILE B 422 -9.858-29.324-63.9541.0033.00 B

ATOM 8306 CDl ILE B 422 -11.071-28.428-63.973 1.0030.76 B ATOM 8307 C ILE B 422 -9.704-30.195-67.6921.0034.16 B

ATOM 8308 O ILE B 422 -10.070-29.386-68.5341.0034.58 B

ATOM 8309 N ASNB 423 -8.781-31.116^67.9241.0033.67 B

ATOM 8310 CA ASNB 423 -8.158-31.242-69.221 1.0032.66 B

ATOM 8311 CB ASN B 423 -7.240-32.467-69.255 1.0031.86 B ATOM 8312 CG ASN B 423 -.5.892 -32.205 -68.611 1.0032.53 B

ATOM ^"8313 ODl ASNB 423 -5.386-31.089-68.642 1.0033.82 B

ATOM 8314 ^~ND2 ASNJB 423 -5.293-33.243-68.045.1,0033:82 B

ATOM -8315- C ASNB 423 -9.242 -3 L379-7D.27-7 LOO 32.53i B

ATOM 8316rθ ASN B 423 -931-0-30.590 -7 L2181.0032.44 B ATOM 8317 N XYR B 424 -1-0,035: -32382 -7β:M0 LOO 32.47 B-

ATOM --§618 CA TΥR-B-4ZΪ -H.164--32.624 -71-.061 1.0032.77 B

ATOM 83-19 CB TYR-B^"424 -12.157-33.642-70.5101.0032.9-6 B

ATOM 8320 CG TYR B 424 -13.33-0-33.897-71.4291.0033.46 B

ATOM 8321 CDl TYRB 424 -13.153-34,499-72.672 1.0034.65 B ATOM 8322 CEl TYR B 424 -14.232-34.728-73.5261.0035.49 B

ATOM 8323 CD2TYRB424 -14.617-33.528-71.058 1.0034.70 B

ATOM 8324 CE2 TYR B 424 -15.704-33.748-71.901 1.0036.24 B

ATOM 8325 CZ TYR B 424 -15.507-34.348-73.135 1.0036.09 B

ATOM 8326 OH TYR B 424 -16.589-34.546-73.9661.0035.40 B ATOM 8327 C TYRB 424 -11.893-31.338-71.371 1.0032.58 B

ATOM 8328 O TYR B 424 -11.936-30.891-72.5201.0033.00 B

ATOM 8329 N LEU B 425 -12.456-30.733-70.3361.00.32.47 B

ATOM 8330 CA LEU B 425 -13.203-29.498-70.5091.0032.64 B

5 ATOM 8331 CB LEU B 425 -13.7L0 -28.994 -69.1541.0031.77 B

ATOM 8332 CG LEU B 425 -14.831-29.840-68.553 1.0030.52 B

ATOM 8333 CDl LEU B 425 -15.266-29.259-67.221 1.0031.46 B

ATOM 8334 CD2 LEU B 425 -16.002-29.872-69.521 1.0030.78 B

ATOM 8335 C LEU B 425 -12.431 -28.401 -71.22« 1.0031.96 B

10 ATOM 8336 O JLEUB 425 -12.978-27.748-72.1091.0031.59 B

ATOM 8337 N LEUB426 -11.170-28.187-70.862 1.0031.68 B

ATOM 8338 CA LEU B-426 -10.407 -27.152 -7L531 1.0032.06 B

ATOM 8339 CB LEU B 426 -8.968-27.064-71.0271.0030.38 B

ATOM 8340 CG LEU B 426 -8.247-25.960-71.8141.0029.35 B

15 ATOM 8341- CDl LEU B 426 -8.751 -24.610 -71.335 1.0027.74 B

ATOM 8342 CD2LEUB426 -6.747-26.052-71.651 1.0029.88 B

ATOM 8343 C LEU B 426 -10.383-27.460-73.0171.0033.75 B

ATOM 83440 LEU B 426 -10=684 -26.585 -73.S30 1.0034.44 B

ATOM 8345 N LYS B 427 -10.127-28.686-73.391 1.0034.34 B

20 ATOM 8346 CA LYS B 427 -1CL115 -29.058 -74.7691.0034.20 B

ATOM 8347 CB LYS B 427 -9.816-30.473-74.924 1.0034.34 B

ATOM 8348- CG LYS B 427 -9.218 -3^72S -76.210 I. θθ 3.7.42 -B

ATOM 8349 CD LYS B 427 -8.912-32.168-76.4201.0040.30 B

ATOM 8350 CE LYSΕ 427 -9.720 \=32.70S -77.5371.0041.48 B

25. ATOM 8351 NZ LYS B 427 -11.008 -33.3S9--77.15-1 1.00 U39 B*

ATOM 8352 C LYS B 427 -11.363-28.808.-75.4261.0034:07 B

AfθM 8353 O LYS B 427 -Il.4t9-28J3.28 -76.461 1.0034.86 B

ATOM 8354 N METB-428 -12.414-29.143-74.802 LGO 33.18 B

ATOM 8355 CA MET B 428 -13.721-28.813-75.353 1.0033.12 B-

30 ATOM 8356 CB^ MET B 428 -14.859-29.351-74.4721.0034.54 B

ATOM 8357 CG MET B 428 -15.100-30.856-74.5541.0036.71 B

ATOM 8358 SD MET B 428 -15.382-31.481-76.241 1.0037.67 B

ATOM 8359 CE MET B 428 -17.028-30.824-76.5751.0035.75 B

ATOM 8360 C METB 428 -13.836-27.295-75.451 1.0032.29 B ATOM 8361 O MET B 428 -14.429-26.774-76.388 1.0033.05 B

ATOM 8362 N ALA B 429 -13.266-26.588-74.479 1.0030.73 B

ATOM 8363 CA ALA B 429 -13.321-25.131-74.4601.0028.78 B

ATOM 8364 CB ALA B 429 -12.683-24.603-73.186 1.0026.58 B ATOM 8365^" C ALA B 429 -12.599-24.573-75.680 1.0028.67 B

ATOM ^'8366 Θ ALA B 429 -13.104-23.676-76.364 1.0027.48 B

ATOM 8367 N LEUB 430 -11.418-25.130-75.9371.0028.44 B

ATOM 8368 CA LEU B 430 -10.571-24.730-77.0471.0028.94 B

ATOM 8369 CB LEU B 430 -9.262-25.513-77.023 1.0026.51 B ATOM 8370 CG LEUB 430 -8.217-25.243-75.948 1.0024.70 B

ATOM -8371 CDl LEU-B 430 -6.987-26.068-76.265 1.0022.69 B

ATOM 8372 CD2XEUB430 -7.860-23.772-75.9171.0024.52 B

ATOM 8373 C LEU B 430 -11.231-24.960-78.3961.0030.73 B

ATOM 8374 O LEU B 430 -10.827-24.384-79.4041.0031.10 B - ATOM 8375 N GLUB 431 -12.341-25.621-78.441 1.0031.98 JB

ATOM 8376 CA GLU B 431 -12.928 -25.928 -79.6901.0G 33.80 B

ATOM 8377 CB GLUB 431 -13.025-27.405-79.7761.0036.38 B

ATOM 8378 CG GLU B 431 -L3.932 -27.995 -80.7801.0041.31 B

ATOM- 8379 CD GLU B 431 -14.103-29.438-80.5291.0045.44 B ATOM 8380 OEl GLUB 431 -13.268-30.011-79,819 1.0046.77 B

ATOM -8381 OE2 GLUB 431 -15.071-29.984-81.029 1.0046.06 B

ATOM 8382- C GLUB-431 -14.248-25.357-79.748 1.0033.95 R

ATOM 8383 O GLU-B- 431 -14.649 -24.834 -80.750 1.0034.32 JB

ATOM 8384 N- LYS B 432_ -14.955 -25.375 -78%6371.0034.39 J& - ATOM 8385-CA LYSJB 432^" -16.256 -24.733 -78.5771^".OO 33.67 JB

ATOM 8336 GB LYSB 432 -17.161 -25.522-77.630 J.0033.70 B

ATOM 8387 CG LYS B"432 -17.309 -26.995 -78.0071.0033.41- B

ATOM 8388 CB-LYS B 432 -18.036-27.166-79.3221.0033.36 B

ATOM 8389 CE LYS B 432 -18.136-28.627-79.6871.0032.93 B ATOM 8390 NZ LYS B 432 -18.934-28.805-80.9191.0032.25 B

ATOM 8391 C LYS B 432 -16.242-23.256-78.180 1.0032.87 B

ATOM 83920 LYS B 432 -16.693-22.401-78.945 1.0033.01 B

ATOM 8393 N ILE B 433 -15.717-22.946-77.001 1.0031.30 B

ATOM 8394 CA ILE B 433 -15.724-21.562-76.563 1.0030.51 B ^

ATOM 8395 CB ILE B 433 -15.300-21.463-75.083 1.0030.83 B

ATOM 8396 CG2 ILE B 433 -15.023-20.012-74.6891.0031.63 B

ATOM 8397 CGl ELE B 433 -16.430-22.003-74.2071.0028.93 B

ATOM 8398 CDl ILEB 433 -16.029-22.195-72.7801.0029.82 B ATOM 8399- C ILEB-433 -14.907-207623-77.4421.0030.13 B

ATOM 8400 O DLEJB 433 -15.382-19.542-77.783 1.0Θ3L81 B

ATOM 8401 N ALAB 434 -13.700-21.019-77.831 1.0028.91 B

ATOM 8402 CA ALA B 434 -12.873-20.161-78.6941.0027.84 B

ATOM -8403 CB ALA B 434 -1X589 -20r907 -79.1141.0027.03 B ATOM 8404 C ALA B 434 -13.609-19.657-79.951 1.0026.74 B

ATOM 8405 O ALA B 454 -13.344-- 18350 -80.442 LOG 25.87 B^"

ATOM 8406-N PHE B 435 -14.537 -20.424^" --80.476 LOO 26.07 B

ATOM 8407 CA PHE B 435 -15.224 -20.110 -81.7071.0026.73 B

ATOM 8408 CB PHEB 435 -16.100-21.245-82.124 1.0026.38 B ATOM 8409 CG PHE B- 435 -16^".776-21.093 -83.488 1.0025.49 B

ATOM 8410 CDl PHE B 435 -16.206-21.486-84.5821.0023.32 B

ATOM 8411 CD2PHEB435 -18.014-20.620-83.608 1.0025.92 B

ATOM 8412 CEl PHE B 435 -16.805-21.348-85.6571.0024.18 B

ATOM 8413 CE2PHEB435 -18.557-20.518-84.7241.0025.71 B ATOM 8414 CZ PHEB 435 -17.966 -20.864 -85.721 1.00r24.43 B

ATOM 84Ϊ-5 C PHER435 -T6.0-59 -18.952 -81,6521.0021.35 B

ATOM 8416 O PHEΕT4J5 -16.147-18.236-82.578 1,0029.21 B

A^OM- 8417 N LEU B 436 -1-6.709-18.69-1-80.-5691.0026.16. B

ATOM 8418_^CA XEUΕ 436 -17.946 -1-8.021 -80.596- JL00-26.66 ^"B ATOM 8419 CB-LEU-B 43& -18.569--18.078-79.2361.0026.56 B

ATOM -8420 CEF LEU B 436 -18.902 -19.184 -78:302 1-0027:76^" JB^~

ATOM- 8421 CDrLΕU_BJ3_6 -18.732-1-8.628-77.0401.0027.07 B

ATOM 8422 CD2 LEU B 436 -20.272-19:48θ-78.3991.0027.64 B

ATOM 8423 C LEUB 436 -17.880-16.605-80.9661.0027.59 B ATOM 84240 LEUB 436 -18.763 -16.083 -81J671.0026.27 B

ATOM 8425 N PRO B 437 -16.833-15.947-80.5581.0028.11 B

ATOM 8426 CD PRO B 437 -15.933-16.212-79.4741.0027.69 B

ATOM 8427 CA PRO B 437 -16.500-14.654-81.0461.0026.76 B

ATOM 8428 CB PRO B 437 -15.192-14.427-80.3461.0026.35 B ATOM 8429 CG PRO B 437 -14.854-15.477-79.956 1.0027.04 B

ATOM 8430 C PRO B 437 -16.378-14.554-82.509 1.0025.69 B

ATOM 8431 O PROB 437 -16.911-13.678-83.0341.0025.12 B

ATOM 8432 N PHE B 438 -15.673-15.451-83.126 1.0024.48 B ATOM 8433 CA PHEB 438 -15.571 -15.519--84.591 1.0024.62 B

ATOM 8434 CB PHE B 438 -14.496-16.516-85.023 1.0024.68 B

ATOM 8435 CG PHE B 438 -14.337-16.616-86.521 1.0025.78 B

ATOM 8436 CDl PHE B 438 -13.934-15.505-87.269 1.0026.23 B

ATOM 8437 CD2PHEB^'438 -14.594-17.816-8-7.186 H)O 25779 B ATOM 8438 CEl PHEB 438 -13.785 -15.592 -88.6671.0026.18 B

ATOM S439 CE2PHEB438 -14.452-17.913-88.5841.0025.77 B

ATOM 8440 CZ PHE B 438 -14.046 --16.798 -89.323 LOO 24.77 B

ATOM 8441 C PHE B 438 -16.865-15.884-85.3191.0024.39 B

ATOM 8442 O PHE B 438 -17.140-15.369-86.4001.0024.68 B ATOM 8443 N GLYB 439 -17.641-1-6.792-84.743 1.0023.17 -B

ATOM 8444 CA GLY B 439 -18.885-17.181-85.3741.0023.61 B

ATOM 8445 C GLY B 439 -19.987-16.139-85.2451.0024.40 B

ATOM 8446 O GLYB439 -21.056-16.274-85.845 1.0026.18 B

ATOM 8447 N TYRB 440 -19.728-15.100-84.455 1.0024.10 B ATOM 8448 CA TYRB 440 -20.686-14.019-84.2251.0023.13 B

ATOM 8449 CB TYR B 440 -20.726-13,688. -82.7291.00T1.22 B

ATOM 8450 CG TYRB 44D -21.550-12.480-82.37-01.0017:73 B

ATOM 8451 CDl TYRB 440 -22.935 -12:5^2-82.2771.00-19.43 B

ATOM.8452 CEl TYKTB 440 -23.699_^-11.449^~81τ9421.0018.91 B- ATOM 8453 CD2 TYR B 440 -20.943 -1T.253 -82rl21 1.0015.53 B

AT-OM--8454 CE2 TYRB 440 -21.693-10.135-81.7881.0016.21 -B

ATOM 8455 CZ TYR 3-440 -23.070 -10.238-81.7Q2-J..0018.05 B-

ATOM- 8456 OH TYR B 440 -23.831 -9.131 -81r401 1.0020.17 B

ATOM 8457 C TYR B 440 -20.209-12.797-85.0001.0023.84 B^ ATOM 8458 O TYR B 440 -20.986-11.940-85.418 1.0025.03 B

ATOM 8459 N LEU B 44-1 -18.903-12.745-85.1741.0023.39 B

ATOM 8460 CA LEU B 441 -18.217-11.670-85.853 1.0022.80 B

ATOM 8461 CB LEUB 441 -16.741-11.818-85.4841.0020.85 B

ATOM 8462 CG LEU B 441 -15.470-11.530-86.266 1.0021.52 B ATOM 8463 CDl LEU B 441 -14.325-12.121-85.415 1.0021.36 B

ATOM 8464 CD2 LEUB 441 -15.475-12.151-87.655 1.0020.32 B

ATOM 8465 C LEUB 441 -18.462-11.670-87.3641.0023.57 B

ATOM 84660 LEUB 441 -18.984-10.694-87.9161.0023.79 B ATOM 8467 N VAL B 442 -18.130-12.783-88.015 1.0023.68 B-

ATOM^" 8468 CA VAL B 442 -18.274-12.936-89.465 1.0023.91 B

ATOM 8469 CB VAL B 442 -18.218-14.421-89.882 1.0021.83 B

ATOM 8470 CGl VAL B 442 -18.404-14.539-91.383 1.0019.80 B

ATOM 8471 CG2VALB442 -16.897-15.027-89.4791.0019.93 B ATOM 8472 C VAL B 442 -19.509-12.332-90.142 1.0025.41 B ATOM -8473 O VALB 442 -19.392 -11.4.59 -91.012 1.0025.68 B ATOM 8474 N ASP B 443 -20.689 -12.798 -89.7591-JttO 2627 3 ATOM 8475 CA ASP B 443 -21.885-12.293-90.3991.0028.03 B ATOM 8476 CB ASP B 443 -23.056-13.231-90.164 1.0027.15 B ATOM 8477 CG ASP B 443 -23.372-14.061-91.390 1.0025.03 B ATOM 8478 ODl ASP B 443 -22.415-14.441-92.1071.0020.25 B ATOM 8479 OD2 ASPB 443 -24.574-14.327-91.6241.0025.74 B ATOM 8480 C ASP B 443 -22.292-10.869-90.093 1.0029.99 B ATOM 8481 O ASP B 443 -23.096-10.292-90.828 1.0032.16 B ATOM 8482 N GLN B 444 -21.777-10.268-89.031 1.0031.06 B

ATOM 8483 CA GLN B 444 -22.184 -8.895 -8S.S48 1.0032.30 B^~-

ATOM 8484 -CB GLNB 444 -22.254 -8.482-87.381 JLOJO.35.51 B

ATOM 8485. CG GbN B 444 -21.193 -8.955 -86.445.1-.Θ038,94 B

ATOM 8486 CD GLN B 444 .=21.491 -8^428-837049 1.0042.08 -B -ATOM- 8487 OEl GLN-Br444=- -20.770 -8.701~84.0S8- 1.0045.76 B

ATOM- 848« NE2 GLNB 444- -2236? -7:649-84.9191.004237 B

ATOM 8489 C GLNB^"444 -21.247 -8.027-89:6551.0030:60 B

ATOM 8490 O GLN B 444 -21.441 -6.820-89.7901.0029.99 B

ATOM 8491 N TRP B 445 -20.228 -8.672-90.2091.0Λ29J2 B ATOM 8492 CA TRP B 445 -19.300-7.977-91.075 1.0028.72 B

ATOM 8493 CB TRP B 445 -18.021 -8.792-91.323 1.0028.06 B

ATOM 8494 CG TRP B 445 -17.113 -8.169-92.3781.0025.40 B

ATOM 8495 CD2TRPB445 -17.012 -8.552-93.7571.0023.83 B

ATOM 8496 CE2 TRP B 445 -16.129 -7.645-94.382 1.0022.26 B ATOM 8497 CE3 TRP B 445 -17.587 -9.570-94.5261.0022.71 B

ATOM 8498 CDl TRP B 445 -16.300 -7.075-92.2291.0023.90 B

ATOM 8499 NEl TRP B 445 -15.710 -6.754-93.4291.0022.47 B

ATOM 8500 CZ2 TRP B 445 -15.807 -7.729-95.736 1.002L86 B ATOM 8501 CZ3 TRP B 445 -17.269 -9.652-95.8721.0022.16 B

ATOM 8502 CH2 TRP B 445 -16.385 -8.736-96.463 1.0022.16 B

ATOM 8503 C TRP B 445 -20.101 -7.902-92.3681.0028.46 B

ATOM 8504 O TRP B 445 -20.326 -6.807-92.903 1.0030.49 B

ATOM -3505 N ARG B 446 -20.557 -9.066-92.8411.0025.27 B ATOM 8506 CA ARG B 446 -21.321 -9.144-94.084 1.0024.20 B

ATOM.8507 CB ARG B 446 -21.588 -11X600 -94.4841.0024.70 B

ATOM 8508 CG ARG B 446 -20.389 -11.284: -95.1341.0025.19 B

ATOM 8509 CD ARG B 446 -20.743 -12.588 -95.832 1.0023.67 B

ATOM 8510 NE ARG B 446 -21.308-13.572-94.9201.0023.27 B ATOM 8511 CZ ARG B 446 -2.1.157-14.884-95.0571^'.0O 23.25 B

ATOM 8512 NHl ARG B 446 -20.453 -15.375 -96.0661.Q0-24.27 B

ATOM 8513 NH2ARGB446 -21.709-15.707-94.182 1.0024.50 B

ATOM 8514 C ARG B 446 -22.632 -8.376-94.1131.0023.65 B

ATOM 8515 O ARG B 446 -23.069 -7.946-95.1791.0023.61 B ATOM 8516 N TRP B 447 -23.279 -8.206-92.9671.0023.36 B

ATOM 8517 CA TRP B 447 -24.524 -7.455-92.9791.0023.46 B

ATOM 851S-CB-TRPB447 -25.261 -7.569-91.6331.-0026.04 B

ATOM 85-19 CG TRPB 447 -25.692 -8.947 -91.2761.0029,13 B

ATOM 8520 CD2TRPB-447 -26.03« -9τ424.89.-9701.00_31.29 E ATOM 8521 CE2 TRP B-44? -26τ36-9 -1O.8ΘO-9OΛ)£91.0032.36 B

ATOM- 8-522 CE3 TISEnB 447 -26vO96 -8^~.828 -88.703 hθθ-_3-K85- B-

ATOM- 8523 CDl TRP B 447 -25-.830.-10.014 -927120 170030r54 B

ATOM 8524 NEl TRP B 447 -26.236 -11.136 -91.420 1.0032.00 B

ATOM 8525 CZ2TRPB447 -26.750-11.58-5-89,013 1.00.33.66 B ATOM 8526 CZ3 TRP B 447 -26.476 -9.603 -87.618 LOO 32.67 B

ATOM 8527 CH2 TRP B 447 -26.799-10.972-87.779 1.0035.35 B

ATOM 8528 C TRP B 447 -24.162 -6.006-93.246 LOO 21.05 B

ATOM 8529 O TRP B 447 -24.925 -5.261-93.8361.0018.57 B

ATOM 8530 N GLYB 448 -22.974 -5.623-92.8011.0020.70 B ATOM 8531 CA GLY B 448 -22.521 -4.261-92.9801.0021.65 B

ATOM 8532 C GLY B 448 -22.168 -3.979-94.421 1.0022.15 B

ATOM 8533 O GLYB 448 -22.321 -2.843-94.9031.0021.52 B

ATOM 8534 N VAL B 449 -21.674 -5.015-95.0991.0021.84 B ATOM 8535 CA VAL B 449^' -21.312 -4.918-96.5071.0019:92 B

ATOM 8536 CB VAL B 449 -20.458 -6.115-96.9401.0020.08- B

ATOM 8537 CGl VAL B 449 -20.309 -6.130-98.4391.0022.16 B

ATOM 8538 CG2 VAL B 449 -19.088 -6.016-96.2971.0020.38 B

ATOM 8539 C VAL B 449 -22.604 -4.871-97.309 1.0018,18 B ATOM 8540 O VAL B 449 -22.807 -3.963-98.098 1.0017.89 B

ATOM 8541 N PHE B 450 -23,484 -5.834 -97:0861.0016.88- B

ATOM -8542 -GA PHE B 450 -2.4.761 -5:862-97.7691.0018.09 B

ATOM 8543 CB PHE B 450 -25.573 -7.076-97.3041.0020.16 B

ATOM 8544 CG PHE-B 450 -25.095 -8.387-97.8691.0022.38 B ATOM 8545 CDl PHEJB 450- -25.191 -9.557 -97JL2Ϊ 1.0024.07 B

ATOM 8546 CD2 PHE B 450 -24.583 -8.463-99.1581.0023.27 B

ATOM 8547 CEI PHE B 450 -24.785 -10.789 -97.649 IJO 24.89 B

ATOM 8548 CE2PHEB450 -24.173 -9.689-99.7001.0024.36 B

ATOM 8549 CZ PHE B 450 -24.278 -10.857 -9&940 l.OΘ 25.26 B ATOM 8550 C PHE B 450 -25.557 -4.575-97.4981.0018.70 B

ATOM 85510 PHE B 450 -26.367 -4.157-98.3241.0017.84 B

ATOM 8552- N SER B 451 -25.319 -3.93S-96.3521.0019.43 JB-

ATOM 8553 CA SERB 451 -26.05-7 -2.718-95,995 LΘO 20.57 B

ATOM^" 8554 CB SER-B-451 -26.245 -2.608-94,472 Ϊ.Θ021.82^" B ATOM 8555 OG SERJEL451 -25.053 -2.215 -S3.793-l.0024τ55 _JB

ATOM 8556 C SERfB 451 -25Ϊ41-7 -T.435-9&4541.002&82 B

ATOM 8557 O SERB 451 -26.065 -0.388 -96.5221.0020.31 B

ATOM 8558 N GLY B 452 -24.143 -1.513-96,865 1.0021.44 B

ATOM 8559 CA GLYB 452 -23.445 -0.340-97.360-1.0023.20 B ATOM 8560 C GLY B 452 -22.622 0.399 -96.326 LOO 24.32 B

ATOM 8561 O GLYB 452 -21.875 1.303-96.6651.0023.91 B

ATOM 8562 N ARG B 453 -22.544 -0.108-95.1601.0027.69 B

ATOM 8563 CA ARG B 453 -22.002 0.642-94.1251.0030.64 B

ATOM 8564 CB ARG B 453 -22.665 0.115-92.9071.0033.81 B ATOM 8565 CG ARG B 453 -23.550 1.107 -92.281 1.00 42.43 B

ATOM 8566 CD- ARG B 453 -24.988 0.774 -92.178 1.00 48.75 B

ATOM 8567 NE ARG B 453 -25.882 1.918 -92.403 1.00 55.12 B

ATOM 8568 CZ^" ARG B 453 -27.147 1.998 -91.985 1.00 57.28 B ATOM 8569 NHl ARG B 453 -27.694 1.023 -91.283 1.00 58.14 B

ATOM 8570 NH2 ARG B 453 -27.868- 3.071 -92.256 1.00 58.44 B

ATOM 8571 C ARGB 453 -20.556 0.338 -94.122 1.00 30.53 B

ATOM 8572 O ARGB 453 -19.747 1.097 -93.657 1.0030.17 B

ATOM 8573 N THRB 454 -20.243 -0.823 -94.666 1.0029.17^" B ATOM 8574 CA THR B 454. -18.877 -1.253 -94.901 1.00 27.15 B

ATOM 8575 GB THRB 454 -18.543 -2.622 -94.256 LOO 27.92 B

ATΘM 8576- OGl THR B 454 -18,682 -2.545 -92.828 1.0026.76 B\

ATOM 8577 CG2 THR B 454 -17.106 -3.031 -94.613 1.0026.81 B

ATOM 8578 C THR B 454 -18.7S1 -1.400 -96.415 1.00 25.34 B ATOM 8579 O THR B 454 -19.153 -2.444 -96.970 1.00 26.30 B

ATOM 8580 N PRO B 455 -1-8.337 -0.333 -97.108 1.00 23.15 B

ATOM 8581 CD PRO B 455 -18.204 1.022 -96.541 1.0022.07 B

ATOM 8582 CA PRO B 455 -18.176 -0.303 -98.569 1.0022.07 B

ATOM 8583 CB PRO B 455 -18.157 1.195 -98.876 1.0023.09 B ATOM 8584 CG PRO B 455 -17.537 1.780 -97.652 1.0022.15 B

ATOM 8585 C JPRO B 455 -16.877 -KOlO -98.972 1,00 20.35 B

ATOM -8586. O PRO B-455 -16.135 -1.476 -98.121 1.0020.93. B

_ AT-OM- 8587 N PRO B 456 -16.583 -1.116-100.269 1.00 19.21 B

ATOM 85-&8_ CD PRO B 456 -17385 -1.047-1 Q±Ji)2 1.00 18.22 B ^~ -ATOM 8589^ CA PRO B 456 -15.314 -1.815-l-00.5i⁾2 UOO 18.34 B

AT-OM-8590 CB PRO B 456 -15.286 -1.979-102:019 L0.0 17,40- B

ATOM -8591- CG PRO-B 456 -16.742 -2:109-102.351 1.00 17:86 B

ATOM 8592 C PRO B 456 -14.102 -1.049 -99.971 1.00 17.22 J3

ATOM 8593 O PRO B 456 -13.054 -1.628 -99.698 IJOO 16.88 B ATOM 8594 N SER B 457 -14.255 0.256 -99.800 1.00 16.23 B

ATOM 8595 CA SER B 457 -13.143 1.067 -99.335 1.00 16.87 B

ATOM 8596 CB SER B 457 -13.432 2.553 -99.584 1.00 17.26 B

ATOM 8597 OG SER B 457 -14.314 3.088 -98.620 1.00 17.14 B

ATOM 8598 C SERB 457 -12.751 0.851 -97.873 1.00 16.89 B ATOM 8599 O SERB 457 -11.804 1.472-97.387 1.0016.07 B

ATOM 8600 N ARGB 458 -13.472 -0.034-97.184 1.0018.68 B

ATOM 8601 CA ARG B 458 -13.214 -0.349-95.769 1.0018.78 B

ATOM 8602 CB ARG B^" 458 -14.170 0.445-94.8601.0018.27 B ATOM 8603 CG ARGΕ 458 -13.701 1.852-94.5221.0018.64 B

ATOM 8604--CD ARG B 458 -14.594 2.553-93.4881.0019.11 B

ATOM 8605 NE ARG B 458 -15.447 3.564-94.1021.0019.51 B

ATOM 8606 CZ ARG B 458 -16.775 3.510-94.0991.0019.29 B

ATOM 8607 MITARG B-458 -17.396 2:486-93.4991.0019.58 B ATOM 8608 ΗH2 ARG B 458 -17.477 4.451-94.7141.0016.67 B

ATOM 8609 C ARG-B 458 -13.361 -1.838-95.453 1.0017.98 B

ATOM 8610 O ARGB 458 -13.552 -2.211-94.3041.0019.01 B-

ATOM 8611 N TYRB 459 -13.263 -2.685-96.471 1.0017.73 B

ATOM 8612 CA TYRB 459 -13.426-4.126-96.285 1.0017.73 B ATOM 8613 CB TYRB 459 -13.215 -4.884-97.613 1.0015.83 B

ATOM 8614 C& TYRB 459 -14.449 -5.049-98.4891.0015.35 B

ATOM 8615 CDl TYRB 459 -14.413 -5.854-99.6321.0014.78 B

ATOM 8616 CEl TYRB 459 45.534 -6.011-100.4521.0011.68 B

ATOM 8617 CD2 TYR B 459 -15.648 -4.404-98.189 1.0015.38 B ATOM 8618 CE2 TYRB 459 -16.766 -4J61 -98.998 1.0014.73 B

ATOM 8619 CZ TYRB 459^" -16:696 -5367-100.124 1.0012.89 B

ATOM 8620 OH TYR-B 459 -17.«σ4 -5.534-100r995 LOO 15.83 B

ATOM 8621 C TYR B 453 -12.528 -4.741 -95.21_41.0019.51 B

ATOM- 8622 O TYR B 459 -13.005- -5.482 -94.36O 1.0021.54 B ATOM 8623 N ASN=B-46Q -11.235 -4.433 -95.261 1.0020.41 B

ATOM 8624 CA ASNB 460 -1&272 -4.987^~94.3l& 1.0020.66 B

ATΘM_8625 CB ASNB 460 -8:890-5:060-94.972 1.00-21.56 B

ATOM- 8626 CG ASN B 460- -8.292 -6.449-94.9061.0023.55 B

ATOM 8627 ODl ASN-B 460 -8.959 -7.435 -95.232 1.0024.47 B ATOM 8628 ND2 ASN B 460 -7.030 -6.539-94.485 1.0024.05 B

ATOM 8629 C ASNB 460 -10.186 -4.190-93.018 1.0020.59 B

ATOM 8630 O ASNB 460 -9.805 -4.721-91.9691.0020.60 B

ATOM 8631 N PBDE B 461 -10.544 -2.914-93.1041.0019.60 B

ATOM 8632 CA PHE B 461 -10.536 -2.012-91.965 1.0017.93 B _34Q

ATOM 8633 CB PHE B 461 -10.840 -0.601-92.4551.0016.91 B

ATOM 8634 CG PHE B 461 -10.981 0.425 -91.365 l.GO 15.14 B

ATOM 8635 CDl PHE B 461 -9.934 0.688-90.4981.0013.26 B

ATOM 8636 CD2 PHE B 461 -12.141 1.198 -91.2T4 1.0013.51 B ATOM 8637 CEl PHE B461 -10.040- 1.711-89.570 1.0014.48 B

ATOM 8638- CE2 PHE B 461 -12.250 2.215-90.3521.0012.09 B

ATOM 8639 CZ PHEB 461 -11.200 2.476-89.4991.0012.70 B

ATOM 8640 C PHE B 461 -11.588 -2.467-90.961 1.0018.59 B

ATOM 8641 O PHEB 461 -1-1.287-2.592-89.773 1.0021.01 B ATOM 8642 N^" ASE B 462 -12.812 -2:726-91.433 1.0016.77 B

ATOM 8643 CA ASP B 462 -13.894- -3.168-90.553 1.001-6:58 B-

ATOM 8644 CB ASPB-462 -15.266 -2.859-91.1661.0017.50 B

ATOM 8645 CG ASP B 462 -15.624 -1.389-91.0781.0019.26 B

ATOM 8646 ODl ASP B 462 -L5.047 -0.714-90.201 1.0021.52 B ATOM 8647 OD2 ASP B 462 -16.477 -0:903 -91.8561.0019.22 B

ATOM 8648 C ASP B 462 -13.820 -4.651-90.1941.0016.12 B

ATOM 86490 ASP B 462 -14.519 -5.104-89.286 1.0016.54 B

ATOM 8650 N TRP B 463 -12.982 -5.400-90.908 1.0015.01 B

ATOM 8651 CA TRPB 463 -12.807 -6.81-8-90.643 1.0014.27 B ATOM 8652 CB TRP B 463 -12.048 -7.491-91.7971.0011.57 B

ATOM 8653 CG TRP 3463 -11.729 -8.9S2 -91.6401.0010.09 B

ATOM 8654 CD2 TRP B 463 -12τ665 -10.076^{^}-91.544 1.0010=60 B

ATOM 8655 CE2TRPB463 -11.9Ω5 -11.277-91.476 fcQO L6.60 B

ATOM 8656 CE3 TRfrB÷463 -14.067-10.161-91.5-11.- 1.009.32 B ATOM 8657 CDl TRP B^~463^~ ~K):477 -9.556-91.623: 1.005.82 B

ATOM 8658 NEFTRP B 4S3 -10.579 -10.933 -91-.525^" LOO 11.70- -B

ATOM S659 CZ2TRPB463 -12Λ03_-12.533 -91.375 1.009rϊ5 B

ATOM 8.660 CZ3TRPB463 -14.655 -1T.415 -91.414 LOO 8.60 B

ATOM 8661 CH2 TRPB 463 -13.873-12.581-91.3471.009.28 B ATOM 8662 C TRP B 463 -11.989 -6.855-89.3701.0016.24 B

ATOM 8663 O TRP B 463 -12.422 -7.397-88.3641.0017.20 B

ATOM 8664 N TRP B 464 -10.813 -6.244-89.399 1.0018.19 B

ATOM 8665 CA TRP B 464 -9.966 -6.242-88.2201.0019.18 B

ATOM 8666 CB TRP B 464 -8.548 -5.803-88.599 1.0019.70 B ATOM 8667 CG TRP B 464 -7.912 -6.801-89.531 1.0023.27 B

ATOM 8668 CD2TRPB464 -7.404 -8.096-89.175 1.0025.14 B

ATOM 8669 CE2 TRP B 464 -7.081 -8.763-90.374 1.0025.16 B

ATOM 8670 CE3TRPB464 -7.203 -8.759-87.9571.0027Jl B ATOM 8671 CDl TRP B 464 -7^61 -6.740-90.895 fcθrø434 B

ATOM 8672 NEl TRP B 464 -7.367 -7.915-91.410 1.0024.93 B-

ATOM 8673 CZ2TRPB464 -6.570-10.058-90.3921.0027.42 B

ATOM 8674 CZ3 TRP B 464 -6.695-10.052-87.975 1.0028.30 B

ATOM 8675 CH2TRPB464 -6.334-10.686-89.1871.00-28.31 B ATOM 8676 C TRP B 464 -10.548 -5.441 -87.0341.0019.89 B

ATOM 8677 O TRP B 464 -10.185 -5.685-85.881 1.0021.25 B

ATOM 8678 N TYR B 465 -11.444- -4.438-87.28=6 J.0018.77 B

ATOM 8679 CA TYR B 465 -12.057 -3.805-86.1521.0018.09 B

ATOM 8680 CB TYR B 465 -13.080 -2.744-86.5841.0046J8 B ATOM 8681 CG TYR B 465 -H.029 -2.321 -85.4601:0016.12 B^"

ATOM -8682 CDl TYR B 465 -13.693 -1.292-84.5671.0016.61 B

ATOM 8683 CEl TYRB 465 -14.546 -0.937 -83.5081.0014.45 B

ATOM 8684 CD2 TYR B 465 -15.247 -2.983-85.2591.0015.92 B

ATOM 8685 CE2 TYR B 465 -16.098 -2.635-84.204 1.0014.13 B ATOM 8686 CZ TYRB 465 -15.739 -1.613-83.3401.0014.01 B

ATOM 8687 OH^" TYR B 465 -16.586 -1.266 -82.322 LOO 1233 B

ATOM 868S- C TYR B 465 -12.805 -4943 -85.4361.00 Ϊ8.3^~4 B

ATΘM -8689 O TYJRB 465 -12.622 -5.161-84.230 kθθ-18.67 B

ATOM 8690 N- LEUB'466 -13.581 -5.686 -86-2i01.00:17:92 B _ ATOM -8691- CA LEU B 466 -14.3:60 ,6.785 -85.669 KOO 18:25 B

ATOM 8692 CB-LEU B 466 -15.338 -7.294-86.7271,0017.46 B

ATOM 8693^~CG LEU B 466 -Iότ423 -6.290 -87.1051:0019.SA B

ATOM 8694 CDl LEU B 466 -17.222 -£784-88.305 1.0022.61 B

ATOM 8695 CD2 LEU B 466 -17.337 -6J033 -85.913 1:0021.23 B ATOM 8696 C LEU B 466 -13.528 -7.940-85.1591.0018.12 B

ATOM 8697 O LEUB 466 -13.878 -8.552-84.168 1.0018.28 B

ATOM 8698 N ARG B 467 -12.433 -8.246-85.838 1.0018.78 B

ATOM 8699 CA ARG B 467 -11.595 -9.365-85.4351.0019.65 B

ATOM 8700 CB ARG B 467 -10.566 -9.681-86.5271.0019.79 B ATOM 8701 CG ARG B 467 -11.183-10.310-87.778 1.0020.18 B

ATOM 8702 CD ARG B 467 -11.227-11.844-87.702 1.0021.02 B

ATOM 8703 NE ARG B 467 -9.918-12.422-88.018 1.0020.67 B

ATOM 8704 CZ ARG B 467 -9.657-13.724-88.058 1.0019.84 B ATOM 8705 NHl ARG B 467 -8.440-14.152-83.362 1.0020,15 B

ATOM 8706 NH2 ARG B 467 -10.605-14.604-87.790 1.0020.14 B

ATOM 8707 C ARG B 467 -10.914 -9.038-84.1341.0020.66 B

ATOM 8708 O ARG B 467 -10.849 -9.870-83.2261.0022.31 B

ATOM 8709 N THRB 468 -10.410 -7.816-84.028 1.0020.06 B ATOM 8710 CA THRB 468 -9.765 -7.396-82.793 1.0019.25 B

ATOM 8711 CB THRB 468 -8τ920 -6.130 --85.003 1.0018.97 B

ATOM 8712 OGl THRB 468 -7.785 -6.455-83.810 1.0020.37 JB

ATOM 8713 CG2THRB468 -8.431 -5.580-81.678 1.0020.20 B

ATOM 8714 C THRB 468 -10.839 -7.136-81.7341.0018.66 B ATOM 8715 O THRB 468 -10.659 -7.489 -80.573 1.0019.72 B

ATOM 8716 N LYS B 469 -11.959 -6.542-82.135 1.0017.16 B

ATOM 8717 CA LYSB 469 -13.027 -6.275-81.1921.0016.25 B

ATOM 8718 CB LYS B 469 -14.200 -5.574-81.8561.Q0- 17.67 B

ATOM 8719 CG LYS B 469 -15.408 -5.480-80.9341.0017.48 B ATOM 8720 CD LYS B 469 -16.443-4.535-81.481 1.0018.67 B

ATOM 8721 CE LYS B 469 -17.688 -4.530 -80.6361.0017.41 B

-ATOM 8722 NZ LYS B- 469 -18.599-3.425-81.0301:001825 B.

ATOM -8723 C LYSB.469 -13.558- -7.507 -80:4971.00.1-5.81 B-

ATOM- 8724 O LYSB 469 -13.819 -7.4:601-79.306-1.0017745 B AT-OM 8-725 N TYEzB_470 -13..735 -8.603 -81.228 1.0Θ-15.96 B

ATOM: 8726 CA TYRB 470 -14.257 -9.823 "80.628- 1,00.16.18 B

ATOM 8727 CB TYRB 470- -T5T362 -10:415 -81.493 1.0015τ45 B

ATOM 8728 CG TYR B 470 -16.609 -9.571-81.4981.0016.75- B

ATOM 8729 CDl TYRB 47G -16.775 -8L518 -82.413 1.0016.27 B ATOM 8730 CEl TYRB 470 -17.926 -7.721-82.386 1.0015.73 B

ATOM 8731 CD2 TYRB 470 -17.620 -9.797-80.563 1.0016.37 B

ATOM 8732 CE2 TYRB 470 -18.757 -9.010-80.526 1.0015.85 B

ATOM 8733 CZ TYRB 470 -18.908 -7.981-81.4351.0016.48 B

ATOM 8734 OH TYR B 470 -20.052 -7.231-81.3801.0017.51 B ATOM 8735 C TYRB 470 -13.247-10.910-80.288 1.0017.10 B

ATOM 8736 O TYRB 470 -13.133-11.296-79.1271.0018.70 B

ATOM 8737 N GLNB 471 -12.513-11.402-81.2771.0016.61 B ATOM 8738 CA GLN B 471 -11.542-12.460-81.0241.0017.46 B ATOM 8739 CB GLN B 471 -11.029-13.051-82.328 1.0017.33 B ATOM 8740 CG GLN B 471 -11.949-14.057-82.9891.0019.52 B ATOM 8741 CD GLN B 471 -11.330-14.615-84.2421.0018.60 B ATOM 8742 OEl GLN B 471 -11.063-13.886-85.188 1.0020.90 B ATOM 8743 NE2 GLN B 471 -11.082-15.924-84.251 1.0017.36 B ATOM 8744 C GLN B 47T -10.345-11.984-80.234 1.0018.07 B ATOM 8745 O GLN B^" 471 -9.675-12.780-79.5721.00 L8.71 B

ATOM 8746 N GLY B 472 -10.059-10.689-80.322 LOG 17.93 B ATOM 8747 CA GLY B 472 -8.911-10.158-79.6191.0016.31 B

ATOM J8748 C GLY B 472 -7.626-10,698-80.202 1.0016.98 B ATOM 8749 O GLY B 472 -6.696 -11.081 -79.47J 1.0014.55 Ε

ATOM 8750 N ILE B 473 -7.588-10.765-81.531 1.0017.15 B

ATOM 5751 CA ILE B 473 -6.401 -1L223 -82.2371.0018.19 B

ATOM 8752 CB ILE B 473 -6.626-12.552-82.961 1.0016.74 B ATOM -8753 CG2 ELE B 473 -7.034-13.606-81.960 1.0016.70 B ATOM 8754 CGl DLE B 473 -7.669-12.379-84.061 1.0016.85 B ATOM 8755 CDl DLE B 473 -7.782-13.556-84.980-1.0016.24 B ATOM 8756 C ELE B 473 -6.000-10.172-83.260 1.001-9.83 ^"B-

ATOM 8757 O ELE-B 473 -6J749 -9r228L-83.5241.G02G.-01 B

ATOM_:8758 N CYS B 474 -4.824 -10:333-83:8471.0022.15 B ATOM ^875-9 CA CYS B 474- -4.352 -9.365-84.8211.00-23.5-1 B AT©M 876.0. CB-CYSB 474 -3:662 -8.231-84.085 1.0024.65 -Br ATOM 87-61 SG CYS B 474 -2.172 =8.808 -83.1021.00-24:16 B^"

ATOM 8762 C CYS B 474 -3,388 -9.938-85.868 1.0023.71 B

ATOM 8763 O CYS B 474 -2.666-10.903-85.6071.0022.14 B ATOM 8764 N PRO B 475 -3.367 -9.335-87.071 1,0025.06 B ATOM 8765 CD PRO B 475 -4.237 -8.222-87.4961.0026.16 B ATOM 8766 CA PRO B 475 -2.498 -9.762-88.172 1.0025.42 B ATOM 8767 CB PRO B 475 -2.925 -8.847-89.3231.0026.73 B ATOM 8768 CG PRO B 475 -3.460 -7.628 -88.6301.0026.83 B ATOM 8769 C PRO B 475 -1.019 -9.637 -87.820 1.00 25.13 B

ATOM 8770 O PRO B 475 -0.560 -8.596 -87.358 1.00 23.86 B

ATOM 8771 N PRO B 476 -0.255 -10.711 -88.043 1.00 25.82 B

ATOM 8772 CD PRO B 476 -0.753 -11.974 -88.612 1.0026.19 B

ATOM 8773 CA PRO B 476 1.181 -10.798 -87.767 IJOO 26.10 B

ATOM 8774 CB PRO B 476 1.425 -12.294 -87.766 1.00 25.78 B

ATOM 8775 CG PRO B 476 0.520 -12.746 -88.861 1.0026.77 B

ATOM 8776 C PRO B 476 2.049 -10.078 -88.796 1.00 25.59 B

ATOM 8777 O PRO B 476 3.277 -10.199 -88.788 1.0024.57 B

ATOM 8778. N VAL B 477 1.386 -9.319 -89.664 1.00 24.80 B

ATOM 8779 CA VAL B 477 2.030 -8.580- -90.738 1.00 23.37 B

ATOM- 8780 CB VAL B-477 2.239 -9.532 -91.953 1.00 22.93 B

ATOM 8781 CGl VAL B 477 0.972 -9.605 -92.797 1.0021.82 B

ATOM 8782 CG2 VAL B 477 3.419 -9.083 -92.776 1.0025.00 B

ATOM 8783 C VAL B 477 1.083 -7416 -91.103 1.0022.54 B

ATOM 8784 O VAL B 477^" -0.152 -7.584 -91.064 1.00 22.63 B

ATOM 8785 N THR B 478 1.617 -6.246 -9L446 1.0021.26 B

ATOM 8786 CA THR B 478 .0.757 -5.114 -91.790 1.0020.56 B

ATOM 8787 CB THR B 478 1.567 -3.915 -92.264 1.00 19.69 B

ATOM 8788. OGl THR B 478 2.478- -3.498 -91.240 1.0020.10 B ATOM 8789 CG2 THR B 478 0,643 -2.779 -92.578 1.0020.39 B

ATOM 8790- C THR B 478 -0.237- -5.471 -92.887 1.8021.13- B

ATOM 875H- O THRB 478 0J078 -6.266 -93.768 1.0021,45. B

ATOM ^"8792-N ARG B 479 -1M9- -4.879 -92.844 1.00 21,30 B-

ATOM 8793 CA ARG B 479 -2.4.09 -5.169 -93.833 1-.00_22.53 B

ATOM 8794 CB ARGB 479 -T.507 -6U 19-93.242 1.00 21:09 B

ATOM 8795 CG ARG B 479 -2.93.9 -7.246 -92.433 1.00 21.52 B

ATOM 8796 CD ARG B 479 -2.159 -8.158 -93JΩ0 1.00 22.82 B

ATOM 8797 NE ARG B 479 -3.017 -8.801 -94.307 1.00 23.15 B

ATOM 8798 CZ ARG B 479 -2.573 -9.326 -95.439 1.00 22.20 B

ATOM 8799 NHl ARG B 479 -1.283 -9.280 -95.734 1.00 22.80 B

ATOM 8800 NH2 ARG B 479 -3.419 -9.904 -96.268 1.0021.59 B

ATOM 8801 C ARG B 479 -3.214 -3.924 -94.272 1.0024.19 B

ATOM 8802 O ARG B 479 -3.797 -3.245 -93.441 1.00 26.76 B ATOM 8803 N ASN B 480 -3.322 -3.722 -95.581 1.00 25.97 B

ATOM 8804 CA ASN B 480 -3.849 -2.552 -96.292 1.0025.71 B

ATOM 8805 CB ASN B 480 -2.987 -2.054 -97.511 1.00 27.10 B

ATOM 8806 CG ASN B 480 -1.450 -2.240 -97.377 1.00 31.00 B ATOM 8807 ODl ASN B 480 -0.846 -1.783-96.464 1.00.31.78 B ATOM 8.808 ND2 ASN-B 480 -0.831 -2.830 -98.383 1.00 31.48 B

ATOM 8809 C ASN B 480 -5.209 -2.847 -96.832 1.00 25.18 B

ATOM 8810 O ASN B 480 -5.593 -3.926 -96.867 1.00 24.72 B

ATOM 8811 N GLU B 481 -5.941 -1.857 -97.262 1.0024.32 B ATOM 8812 CA GLU B 481 -7.182 -2.106 -97.963 1.0023.20 B

ATOM- 8813 CB GLU B 481 -7.984 -0.815 -98.046 1.00 22.02 B ATOM 881-4: GG GLU 3481 -9.483 -1.047 -98.003 1.00 24.43 B

ATOM 8815 CD GLU B 481 -9.960 -1.589 -96.665 1.0025.83 B ATOM 8816 OEl GLU B 481 -9.774 -0.894 -S5.641 1.00 28.10 B ATOM 8817 OE2 GLU B 481 -10.525 -2.703 -96.635 1.00 26.85 B

ATOM 8818 C GLU B 481 -7.052 -2.745 -99.344 1.00 22.87 B

ATOM 8819 0 GLUB 481 -8.052 -2.910-100.039- 1.0023.55 B

ATOM 8820 N THRB 482 -5.836 -3.098 -99.757 1.00 21,93 B ATOM 8821 CA THR B 482 -5.692 -3.762-101.046 1.0022.72 B ATOM 8822 CB THRB 482 -4.319 -3.466-101.756 LOO 24.82 B ATΘM 8823 OGl THR B 482 -3.336 -4.436-101.366 1.0026.37 B ATOM -8824 CG2 THRJB 482 -3τ821 -2X173-101.4-15 1.00 25:89 B

ATOM 8S25-C THRB 482 -5.8J 8 -5.255-100.722 1.0022.02 B

ATOM 8826 O THRB.4:82. -5.803 -6.114-lflh607 1.00-21.43: B ATOMr-8827 N MS B^"483 -5.946 -5.537 -99.425 1.O0 22.24 B-

ATOM- 8828- CA HIS B 483 -6Λ15- -6.897 -98T921 1.00 21.L0 B

ATOM 8829 CB HIS B 483 -5.382 -7.099 -97.600 1.00 20,30 B

ATOM 8830-CG HIS B 483 -3.897 -6.985 -97,709 1.00 19.96 B

ATOM -8831 CD2 HIS B 483 -3.021 -7.541 -98.574 1.00 19.51 B ATOM^" 8832 NDl HIS B 483 -3.143 -6.236 -96.831 1.0021.39 B

ATOM 8833 CEl HIS B 483 -1.866 -6.337 -97.149 1.00 19.71 B

ATOM 8834 NE2 HIS B 483 -1.765 -7.124 -98.203 1.00 20.36 B

ATOM 8835 C HIS B 483 -7.591 -7.168 -98.700 1.00 20.82 B

ATOM 8836 O HIS B 483 -8.414 -6.246 -98.582 1.00 19.58 B , „

346

ATOM 8837 N PHE B 484 -7.914 -8.452 -98.649 1.00 20.63 B

ATOM 8838 CA PHE B 484 -9.283 -8.888 -98.462 1.0022.09 B

ATOM 8839 CB PHE B 484 -9.949 -9.143 -99.813 1.00 23.48 B

ATOM 8840 CG PHE B 484 -11.427 -9.392 -99.721 LOO 25.70 B ATOM 8841 CDLPHE B 484 -127031 -10.371-100.514 1.00 25.87 B

ATOM 8842 CD2 PHETB-484 -121215 -8.654 -98.842 1.0025.94 B

ATOM 8843 CEl PHE B 484 -13.390 -10.614-100.436 1.0025.02 B

ATOM 8844 CE2 PHE B 484 -13.577 -8.890 -98.755 1.0025.65 B

ATOM 8845 CZ PHE-B-484 -14.166- -9.875 -99.556 1.0026:07 B ATOM 8846 C PHE B 484 -9.219 -10.173 -97.664 1.00 22.37 B

ATOM 8847 O PHE=B 484 -96484 -11.263 -98.181 1.00 22.88 B-

ATOM- 8848 N ASP B 485 -8.864 -10.031 -96.394: 1.00 21.94 B

ATOM 8849 CA ASP B 485 -8.735 -11.169 -95.515 1.0021.40 B

ATOM 8850 CB ASP B 485 -8.019 -10.727 -94.240 1.00 19.72 B ATOM 885r CG ASP B 485 -6.603 -10.220 -94.517 1.0020.20 B

ATOM 8852 ODl ASP B 485 -5.857 -10.899 -95.251 1.0020.06 B

ATOM 8853 OD2 ASP H 485 -6.222 -9.153 -93.996 1.00 19.08 B

ATOM 8854 C ASP B 485 -10.055 -1 L884-95.213 1.00 21.78 B

ATOM 8855 O ASP B 485 -10.051 43.075 -94.914 1.0022.24 B ATOM 8856 N ALA B 486 -11.177 -1L171 -95.313 LOO 21.98 B

ATOM 8857 CA ALA^ 486 -12.483 -11.781-95.061 LOO 21.13 B

ATOM 8858 CB ALA B 486 -13.576 -10.727-95.0.36 LOO 18τ95 B

ATOM 8859=G ALALB 486- -12.758 -12.755 -96.182 1.0021.87 B

ATOM-8860 Or ALA B 486 -13.482 -13.732 -96efl20.-l.0022.07 B- ATOM 8S61-N- GLY B 487 -12rl69--12.485 -97.336 1.0021.75 B

ATOM- 8862 CA GLY B 487 -12.4ΘG -13.349--98.469 1.00-21.28- B-

ATOM 8863 C GLY_B 48-7 -11.616-14.639^98.428 1.00 20.50 B

ATOM 8864 O GLY B 487 -11.822 -15.512 -99.279 1.00 20.85 B

ATOM 8865 N ALAJB 4.88 -10.726 -14.774 -97.452 1.00 18.63 B ATOM 8866 CA ALA B 488 -9.919 -15.980 -97.348 1.00 18.60 B

ATOM 8867 CB ALA B 488 -8.598 -15.663 -96.705 1.00 18.11 B

ATOM 8868 C ALA B 488 -10.616 -17.066 -96.568 1.00 19.71 B

ATOM 8869 O ALA B 488 -10.044 -18.118 -96.325 1.0020.53 B

ATOM 8870 N LYS B 489 -11.848 -16.821 -96.215 1.0020.05 B ATOM 8871 CA LYS B 489 -12.738-17.794-95.660 1.0020.64 B

ATOM 8872 CB LYS B 489 -12.983-17.504-94.1871.0019.40 B

ATOM 8873 CG LYS B 489 -14.229-18.019-93.5321.0017.90 B

ATOM 8874 CD LYS B 489 -14.047 -1S.833 -92.3801.0018.48 B- ATOM- 8875 CE LYS B^" 489 -13.9-1-5 -20.182 -92.790 1.0021.87 B

ATOM- 8876 NZ LYS B489 -14.291-21.16.7-91.8-83 1.00209 B

ATOM 8877 C LYS B 489 -13.904-18.449-96.3781.0021.80 B

ATOM 88780 LYS B 489 -14.787-17.881-96.919 1.0022.40 B

ATOM 8879 N PHE B 490 -13.870-19.724-96.401 1.0021.47 B ATOM 8880 CA PHE B 490 -14.584-20.382-97.3771.0021.35 B

ATOM 8881 CB PHE B 490 -14.895-21.719-96:9171.00-20.27 B

ATOM 8882 CG PHE B 490 -15,621-22.521-97.871 1.0023.32 B

ATOM 8883 CDl PHE B 490 -14.998-23.211-98.8021.0023.37 B

ATOM 8884 CD2 PHE B 490 -16.941 -22.66L-97.7861.0023.45 B ATOM 8885 CEl PHE B 490 -15,669-23.901-99.5991.00-22.06 -B

ATOM 8886 CE2 PHE B 490 -17.563-23.389-98.580 1.0023.18 B

ATOM 8887 CZ PHE B 490 -16.931-23.980-99.4961.0022.06 B

ATOM 8888 C PHE B 490 -15.772-19.642-97.619 1.0021.74 B

ATOM 88890 PHE B 490 -16.114-19.438-98.690 1.0021.15 B ATOM 8890 N HIS B 491 -16.424-19.208-96.6001.0021.62 B

ATOM 8891 CA HIS B 491 -17rS35-19_~155 -96.5961.00-22.36 B

ATOM 889-ZCB HISJB 491 -18.325 -19.198-95.1801.00^~20.39- B

ATOM 8893 CG HIS B-491 -18.344-20,544-9415441,0019.17 B-

ATOM 5894 CD2ΗISB491 -17.-348 -2O37 -94.161 1.0018.04 B ATOM 8895 -NDl HIS B 491 -19.475-21.223-94.2721.00-20:26 B

AEOtA 8896 CEl HIS B-491 -19τl80 -22.365 -93.7261.0018:44- B-

ATΘM 8897 NE2-HIS-B 491 -17.890 -22:456 -_93J641 1.00 ITS.14- B

ATOM 8898 C HIS B 491 -18.172-17.845-97.1041.0024.01 B-

ATOM 8899 O HIS B 491 -19.274-17.544-97.303 1.0024.28 B ATOM 8900 N VAL B 492 -17.189 -16.999 -97.258 1.0023.52 B

ATOM 8901 CA VAL B 492 -17.409-15.691-97.8671.0022.10 B

ATOM 8902 CB VAL B 492 -16.302-14.689-97.488 1.0021.73 B

ATOM 8903 CGl VAL B 492 -16.542-13.357-98.1821.0018.00 B

ATOM 8904 CG2 VAL B 492 -16.286-14.496-95.9881.0021.35 B ATOM 8905 C VAL B 492 -17.517 -15.798 -99.387 1.0022.71 B

ATOM 8906 O VAL B 492 -18.548 -15.440 -99.955 1.0023.17 B

ATOM 8907 N PRO B 493 -16.460 -16.287-100.071 1.00 23.25 B

ATOM 8908 CD PRO B 493 -15.116.-16.652 -99.583 1.00 22.12 B ATOM 8909 CA PRO B 493 -16.533 -16.409-101.536 1.0022.87 B

ATOM 8910 CB PRO B 493 -1-5.108 -16.767-101.935 1.00 21.86 B

ATOM 8911 CG PRO B 493 -14.590 -17.494-100.722 1.0023.02 B

ATOM 8912 C PRO B 493 -17.527 -17.465-101.977 1.00-22.92 B

ATOM 8913 O PRO B 493 -17.880 -17.543-103.145 1.0023.58 B ATOM 8914 N ASNB 494 -17.973 -18.288-101.041 1.0023.61 B

ATOM 8915 CA ASN B 494 -18.941 -19.322-101.369 1.0024.59 B

ATOM 8916 CB ASN B 494 -18.521 -20.660-100.780 i.0θ 25,90 B

ATOM 8917 CG ASN B 494 -17.454 -21.339-101.611 1.0028.15 B

ATOM 891-8 ODl ASN B 494 -17.702 -22.364-102.237 1.00 28.6S B- ATOM 8919 ND2 ASNB 494 -16256 -20.760-101.629 1.00 29.03 B

ATGM 8920 C ASN B 494 -20.325 -18.950-100.594 1.0025.20 B

ATOM 8921 O ASN B 494 -21.213 -19.801-100.797 1.0024.64 B

ATOM 8922 N VAL B 495 -20.48^-17.666-100.588 1.00 25.60 B

ATOM 8923 CA VAL B 495 -21.756 -17.118-100.148 1.0025.05 B ATOM 8924 CB VAL B 495 -22.595 -16.758-101.388 1.0024.04 B

ATOM 8925 CGl VAL B 495 -23.841 -15,989-100.984 1.002315-1- B

ATOM 8-926- CG2 VAL B 495 -21.737 -15.968-102.366 1.0022.54 B

ATOM 8927 C VAL-B 495 -22.570 -18,033 -9.9.227 LOO 24.79 B-

ATOM 8928 O- VAL B 495- -23.694-18.3W -99.549 1.0025,44- B ATOM.^.8929 N- TEK.-B-496 -22.010 -1&419 -98.087 1.00 24.50 B^"

ATOM 8930 CA THRBr4-96- -22.742 -1-9.273 -97.145 1.00 2-3,61 B

ATOM 8931 CB-THR B^"496 -21.984 -20.553 -9όr857 1.0022.45 -R

ATOM 8932 OGTTHRB 496 -21.520 -21. Ϊ0Θ -98.085 1.00 25.04 B

ATOM 8933 CG2 THRB 496 -22.880 -21.554 -96.183 1.00 21.60 B ATOM 8934 C THR B 496 -22.915 -18.526 -95.827 1.0022.98 B

ATOM 8935 O THRB 496 -21.935 -18.232 -95.142 1.0023.15 B

ATOM 8936 N PRO B 497 -24.161 -18.207 -95.451 1.0022.30 B

ATOM 8937 CD PRO B 497 -25.445 -18.577 -96.069 1.0021.40 B

ATOM 8938 CA PRO B 497 -24.365 -17.484 -94.189 1.0023.27 B ATOM 8939 CB PRO B 497 -25.865-17.600-93.964 1.0023.19 B

ATOM 8940 CG PRO B 497 -26.409-17.644-95.378 1.0022.55 B

ATOM 8941 C PRO B 497 -23.539-18.111-93.063 1.0025.01 B

ATOM 8942 O PROB 497 -23.178-19.295-93.131 1.0025.35 B ATOM 8943 N TYRB 498 -23.240-17.321-92.032 1.0025.00 B

ATOM 8944 CA TYR B 498^" -22.414-17.824-90.943 1.0023.81 B

ATOM 8945 CB TYR B 498 -21.086-17.068-90.925 1.0022.78 B

ATOM 8946 CG TYR B 498 -19.898-17.879-90.450 1.0022.73 B

ATOM 8947 CDl TYRB 498 -19.266-18.801-91.2951.0021.12 B ATOM 8948 CEl TYRB 498 -18.144-19.528-90.869 1.0020.25 B

ATOM 8949 CD2TYRB498 -19.382-17.707-89.158 LOO 22.01 B

ATOM 8950 CE2 TYR B 498 -18.263 -18.434 -88.722 1.0021.56 B

ATOM 8951 CZ TYRB 498 -17.652-19.336-89.5821.0021.57 B

ATOM 8952 OH TYR B-498 -16.552-20.034-89.1481.0022.26 B ATOM 8953 C TYRB 498 -23.056-17.757-89.561 1.0024.01 B

ATOM 8954 O TYRB 498 -22.755 -18.601 -88.702 LOO 24.31 B

ATOM 8955 N ELFB 499 -23-.941 -16.781-89.3401.0022.84 B

ATOM 8956 CA ILE B 499 -24.585 -16.642 -S8JO31 1.0023.11 B

ATOM 8957 CB ILE B 499 -25.601-15.481-88.002 1.0022.86 B ATOM 8958 CG2 ILE-B 499 -26.820-15.821-88.845 1.0023.17 B

ATOM 8959 CG-I ILEB 499 -26.021-15.200-86.559 1.0021.43 B

ATOM 8960 CDl BLE B 499 -24.868-14.897-857628 1.00-20.48 B

ATOM 8961 C DLEB-499 -25-300 -17.920 -87,6261.0024.18 B

ATOM 8962 O DLEB-499 -2T.733 -18.085 -86.488 LOD 25.30 B ATOM 8963 -N ARG=B 500 -2&426-18τ8£6 -883781.0024.83 B-

ATOM ^"8964 CA ARG B 500 -2(5.055 -20.095 -88.323 1:00:24.62 -B

ATOM 8965 CB ARGB 500 -26,276 -20.834 --89.6461.0024.42 B

ATOM 8966 CG ARG B 500 -25.026 -20.982 -90.503 1.0024.62 B

ATOM 8967 CD ARG B 500 -25.352-21.660-91.826-1.0025.42 B ATOM 8968 NE ARG B 500 -26.329-20.909-92.6171.0025.62 B

ATOM 8969 CZ ARG B 500 -26.855-21.354-93.7561.0024.71 B

ATOM 8970 NHl ARG B 500 -26.486-22.540-94.221 1.0023.36 B

ATOM 8971 NH2ARGB500 -27.744-20.628-94.425 1.0021.83 B

ATOM 8972 C ARGB 500 -25.133-20.891-87.401 1.0025.51 B ATOM 8973 O ARG B 500 -25.610-21.584-86.5161.0027.23 B

ATOM 8974 N TYRB 501 -23.816-20.775-87.5881.0026.27 B ATOM 8975 CA TYRB 501 -22.866-21.516-86.751 1.0027.17 B

ATOM 8976 CB TYRB 501 -21.469-21.517-87.372 1.0029.69 B 5 ATOM 8977 CG TYRB 501 -21.440-22.217-88.706 1.0032.58 B ATOM 8978 CDl TYRB 501 -21.578-21.491-89.905 1.0034.13 B ATOM 8979 CEl TYRB 501 -21.636-22.140-91.140 1.0036.12 B ATOM 8980 CD2 TYRB 501 -21.358-23.610-88.7771.0032.78 B ATOM 8981 CE2TYRB501 -21.423 -24.270 -90.000 1.0035.09 B

10 ATOM 8982 CZ TYRB 501 -21.56Z-23.529 -91.181 1.0036.82 B ATOM 8983 OH TYRB 501 -21.644-24.180-92.395 1.0037.64 B

ATOM 8984 C TYRB 501 -22.772-21.002-85.331 1.0026.67 B

ATOM 8985 O TYRB 501 -22.426-21.751-84.4181.0025.07 B

ATOM 8986 N PHE B 502 -23.052-19.721-85.1341.0026.31 B

15 ATOM 8987 CA PHE B-502 -23.007-19.18.7-83.785 1.0026.26 B

ATOM 8988 CB PHE B 502 -23.084-17.664-83.8041.0025.65 B

ATOM 8989^" CG PHE B 502 -23.148-17.043-82.418 1.0025.31 B ATOM 8990 CDl PHE B 502 -22.041-17.062-81.595 1.0024.73 B ATOM 8991 CD2 PHE B 502 -24.312-16.421-82.001 1.0024.37 B

2Q ATOM 8992.CE1PHEB502 -22.092-16.467-80:335 1.0024.78 B ATOM -8993 CE2 PHE B 502 -24.376 -15.825 -80.748^" 1.0023.30 B

ATOM- 8994 CZ PHE B 502 -23.267-15.845 -79.912 1.0023,63 B

ATOM 8995 C PHE B 502 -24.230 -19.777 -83.08« 1.0026.78 B

ATJOM 8996 O: JEHB B 502 -24.110 -20.481 -82:077 LOO 2&67 B

25 ATOM 8997 N YAL B-503 -25.408 -19307 -83^643 170026,29 B ATOM: 8998 CA VAL-B.503- -26:637 -207039 -83.072 k0026.30 B

ATOM 8999 GB YAL B 503 -27.806-19.929-84:0741.0023.68 B- ATOM 9000 CGl VAL B 503 -29,043 -20.555 -83.4941.0023.24 B ATOM 9001 CG2VALB503 -28.067-18.477-84.409 1.0023.32 B

3.0 ATOM 9002 C VAL B 503 -26.412-21.514-82.7291.0027.65 B

ATOM 9003 O VAL B 503 -26.726-21.972-81.6261.0028.51 B

ATOM 9004 N SERB 504 -25.829-22.232-83.682 1.0028.76 B

ATOM 9005 CA SER B 504 -25.545-23.653-83.555 1.0030.49 B

ATOM 9006 CB SERB 504 -24.798-24.144-84.798 1.0030.73 B ^

ATOM 9007 OG SERB 504 -24.229-25.429-84.583 1.0031.27 B

ATOM 9008 C SERB 504 -24.757-24.068-82.3201.0031.92 B

ATOM 9009 O SERB 504 -25.110-25.044-81.6501.0033.11 B

ATOM 9010 N PHEB.505 -23.677-23.354-82.0241.0032.41 B ATOM 9011 CA PHEB 505 -22.864 -23 JX 5 -S0.871 1.Θ032.35 B

ATOM 9012 CB PHE B 505 -21.556-22.913-80.868 1.0030.52 B

ATOM 9013 CG PHE B 505 -20.462-23.546-81.6891.0030.14 B

ATOM 9014 CDl PHE B 505 -20.740-24.098-82.938 1.0029.65 B

ATOM 9015 CD2 PHE B 505 -19.158 -23.604 -&1.2141.0029.74 B ATOM 9016 CEl PHE.B 505 -19.746-24.695-83.6901.0029.40 B

ATOM 9017 CE2 PHE B 505 -18.155-24.202-81.9691.0028.79 B

ATOM 9018 CZ PHEB 505 -18.452-24.747-83.205 UOO 29.32 B

ATOM 9019 C PHE B 505 -23.636-23.517-79.575 1.0033.20 B

ATOM 9020 O PHE B 505 -.23.523-24.317-78.645 1.0033.67 B ATOM 9021 N VAL B 506 -24.450-22.471-79.5231.0032.94 B

ATOM 9022 CA VAL B 506 -25.205-22.209-78.3191.0031.30 B

ATOM 9023 CB VAL B 506 -25.749-20.760-78.2921.0030.43 B

ATOM 9024 CGl VAL B 506 -26τ647 -20.554 -77.0771.0029.18 B

ATOM 9025 CG2 VAL B 506 -24.573 -19.773- -78.251 1.0029.59 B ATOM 9026 C VAL B 506 -26.336-23.195-78.1321.0031.57 B

ATOM 9027 O VAL B 506 -26.363-23.901-77.133 1.0033.83 B

ATOM 9028 N LEUB 5X)J -27.259-23.291-79.080 1.0031.35- B-

ATOM 9029 CA LEU B- 507 -28.367-24.214-78.8571.00-31.44 B

ATΘM.9030 CB LEUB-507 -29.581-23.-85.6_^-79:733 1.0032.09 B ATOM 9031 CG LEU B 507 -297914- -24.714 -80.951 1.0031.67 B ATOM -9932 CDl LEU B 507 -3:1.365 -24τ532 -81365 1.00-30743 B

ATOM 9033 CD2 LEUB-507 -28.975-24335-82.0571.0033.01 B

ATOM 9034 C LEUB 507 -28.013 -25.685 -79.0161.0029J73 B

ATOM 9035 O LEU B 507 -28.886-26.544-78.978 1.0028.54 B ATOM 9036 N GLN B 508 -26.735-25.990-79.1741.0028.50 B

ATOM 9037 CA GLN B 508 -26.370-27.386-79.309 1.0029.62 B

ATOM 9038 CB GLNB 508 -25.032-27.513-80.050 1.0030.13 B

ATOM 9039 CG GLN B 508 -23.796-27.915-79.2671.0031.07 B

ATOM 9040 CD GLN B 508 -22.530-27.798-80.130 1.0033.43 B ATOM 9041 OEl GLN B 508 -21.446-28.272-79.753 1.0033.59 B

ATOM 9042 NE2 GLN B 508 -22.664-27.147-81.293 1.0033.69 B

ATOM 9043 C GLN B 508 -26.348-28.015-77.9191.0030.92 B

ATOM 9044 O GLNB 508 -26.604-29.209-77.7561.0031.60 B ATOM- 9045 N PHE B 509 -26.089-27.196-76.903 1.0031.55 B

ATOM 9046 CA THE B 509 -26:081-27.685-75.5341.0030.07 B

ATOM 9047 CB PHE B 509 -25.179-26.816-74.675 1.0028.78 B

ATOM 9048 CG PHE B 509 -23.753-26.873-75.0951.0027.60 B

ATOM 9049^" CDl PHE B 509 -23.269-26.014-76.073 1.0027.04 B ATOM 9050 CD2 PHE B- 509 -22.909-27.841-74.5761.0026.98 B

ATOM 9051 GEl PHE B 509 -21.961-26.119-76.5341.0026.34 B

ATOM 9052 CE2 PHE B 509 -21.603 -27.956 -75.0291.0027.3-5 B

ATOM 9053 CZ PHE B 509 -21.126-27.093-76.0121.0027.04 B

ATOM 9054 C PHE B 509 -27.498 -27.728 -74.975 1.00.29.77 B ATOM 9055^~O PHE B 509 -27.766-28.422-74.0001.0030.21 B

ATOM 9056 N GLNB 510 -28.406-26.982-75.5941.0029.21 B

ATOM 9057 CA GLNB 510 -29.792-27.000-75.1661.0029.1-0 B

ATOM 9058 CB GLN R 510 -30.609-25.948-75.881 1.0026.61 B

ATOM 9059 CG GLNB 510 -30.077-24.563-75.8101.0026.49 B ATOM 9060 CD GLN B 510 -31.20.8-23.597 -75J671 1.0028.48 B-

ATOM 90^'61 ΘE1 GLN-B 510 -31.091-22.420-76.0001.0029.13 B

ATOM 9062 NE2-GLNB510 -32.332--24.094 -75.1531.0029r89 B

ATOM 9063 C GLKB^510 -30.313-28356-75.6001.0030.51 B-

ATOM 9064 O GLNB 510 -3JL13Q -28.975 -74.9-15--LT).a31.71 B- A-TOM 9065 N -PHE-B 511 -297849-28.794-76.769 1.0030.16 B

ATOM 9066 CA -PHE-B.511 -30.-241-30:081-77.3141.0030:02 B

ATOJVL 9067 CB PHE B 511 -29:707 -30.262 -78.735- 1.003-1.23 -B

ATOM 9068 CG PHEd3-511 -30.529-29.585-79.802 1.00-31.79 B

ATOM 9069 CDl P-HEB 511 -31.645-28.825-79.4761.0032.31 B ATOM 9070 CD2 PHE B 511 -30.159 -29.691 -8L141 1.0032.28 B

ATOM 9071 CEl PHE B 511 -32.379-28.180-80.471 1.0033.17 B

ATOM 9072 CE2 PHE B 511 -30.880-29.051-82.1371.0032.71 B

ATOM 9073 CZ PHEB 511 -31.995-28.292-81.803 1.0032.85 B

ATOM 9074 C PHEB 511 -29.632-31.142-76.4291.0029.75 B ATOM 9075 O PHEB 511 -30.323-32.016-75.919 1.0029.42 B

ATOM 9076 N HIS B 512 -28.324-31.050-76.242 1.0029.58 B

ATOM 9077 CA HIS B 512 -27.617-32.010-75.412 1.0030.58 B

ATOM 9078 CB HIS B^" 512 -26.176-31.582=75.2241.0028.52 B ATOM 9079 CG BJS-B-512 -25.311-32.665-74.680 1.0027.19 B

ATOM 9080 CD2 HIS-B 512 -24,229 -32.625^"-73:8701.0027.-89 B

ATOM 9081 NDl HIS B 512 -25.487-33.986-75.025 1.0027.84 B

ATOM 9082 CEl HIS B 512 -24.545-34.715-74.4541.0029.63 B

ATOM 9083 NE2HISB512 -23.767-33.913-73.7471.0029.02 B ATOM 9084 C HIS B 512 -28.246^" -32.213 -74.038 1.0032.36 B

ATOM 9085 O HES B 512 -28τ419 -33.35-1 -737592 1,0032.03 B

ATOM 9086 N GLUB 513 -2S.580 -31.117 -73.35.6- 1.0034,38 B

ATOM 9087 CA GLUB 513 -29.185-31.241-72.041 1.0035.29 B

ATOM 9088 CB GLUB 513 -29.358-29,880-71.374 1.0036.75 B ATOM 9089 CG GLUB 513 -29.900 -^"29.989-69:9491.Θ041.04 B

ATOM 9090 CD GLUB 513 -30.061-28.634-69.275 1.0043.34 B

ATOM 9091 OEl GLU B 513 -30.716-27.761-69.8821.0044.67 B

ATOM 9092 OE2 GLU B 513 -29.543-28.441-68.1451.0045.16 B

ATOM 9093 C GLUB 513 -30.537-31.899-72.201 1.0034.57 B ATOM 9094 O GLUB 513 -30.823-32.920-71.575 1.0035.18 B

ATOM 9095 N -ALA-B 514 -31.360 -3 h.320 -73.0621. GO 33.27 -B

ATOM 9096 CA ALA B-5T4 -32.687-31.855-73.301 1.0032.96 B

ATOM -9097-CB ALA-B-514 -33.369 -31.047 --7_~4;4Θ5 1.0033.50 R

ATΘM 9098- C ALA B 51Ψ -32.680-33.351-73.6521.00τ3A..7t B ATOM 9099 O ALAB-^~51-4 -33.626-34.073-73353 1.0.030708 B

ATOM 9100 N LEU3S-515 -31.609-33.812-74.2821.0031.61- B

ATΘM- 9101 CA LEUΕ-515 -31.514 -35.21-0~74.658 1.0033^07 B

ATOM 9102 CB LEUB 515 -30.666-35.370-75:9241.0032.61 B

ATOM 9103 CG LEU B-515 -31.186-34.706-77.209 1.0033.59 B ATOM 9104 CDl LEUB 515 -30.209-34.983-78.339 1.0032.54 B

ATOM 9105 CD2 LEU B 515 -32.577-35.225-77.566 1.0032.04 B

ATOM 9106 C LEUB 515 -30.934-36.057-73.535 1.0035.01 B

ATOM 9107 O LEUB 515 -31.297-37.223-73.385 1.0035.08 B

ATOM 9108 N CYS B 516 -30.033-35.481-72.741 1.0037.20 B ATOM 9109 CA CYS B 516 -29.444-36.228-71.633 1.0038.92 B

ATOM 9110 C CYS B 516 -30.496-36.464-70.579 1.0039.11 B

ATOM 9111 O CYS B 516 -30.500-37.494-69.9121.0038.07 B

ATOM 9112 CB CYS.B 516 -28.27^Q -35.471 -71.028 1.0039.97 B ATOM 9113 SG CYS B 516 -26.^"866 -35.413 -72.1-761.0043.37 B

ATOM 9114 N LYS B 517 -31.390-35.494-70.429 LOO 39.89- B

ATOM 9115 CA LYSB 517 -32.468-35.611-69.469 1.0040.54 B

ATOM 9116 CB LYS B 517 -33.305-34.333-69.4441.0039.30 B

ATOM 9117 CG LYSB 517 -34.363 -34.354-68.364^' 1.0039.77 Ε ATOM 9118 CD LYS B 517 -35.390-33,252-68.5141.0040.79 B

ATOM 9119 CE LYS B 517 -36.392-33.322-67.3671.0041.93 B

ATOM 9120 NZ LYS^" B 517 -37.554 -32.417 -67.563 1.0042.63 B

ATOM 9121 C LYS B 517 -33.333-36.784-69.9301.0041.76 B

ATOM 91220 LYS B 517 -33.444-37.804-69.242 IJOQ 42.14 B ATOM 9123 N GLUB 518 -33.928-36.635 -71.1O91.0042.78 B

ATOM 9124 CA GLUB 518 -34.784-37.664-71.691 1.0044.13 B

ATOM 9125 CB GLUB 518 -35.181-37.261-73.121 1.0044.83 B

ATOM 9126 CG GLUB 518 -36.348-38.048-73.7121.0045.29 B

ATOM 9127 CD GLUB 518 -37.703-37.577-73.193 1.0046.06 B ATOM 9128 OEl GLUB 518 -38.731-38.1=78-73.5821.0046.08 B

ATOM 9129 OE2 GLU B 518 -37.737-36.682 -72AQ61.0.045.56 B-

ATOM 9130 C GLUB318 -34.D9J -39.034 -71.716 J.ΘO-44,53 B-^"

ATOM 9131 O- GLU-B-518 -.34.750-40.0.72-71.749 1.0044.63 B

ATOM 9132 N AEA-B 519 -32.763 -39.038 -71,74SI .0044.67 B ATOM--9133 CA ALA B 519 -32.017-40.294-71.766-1:0045.08 B

ATOM 913i4~eB ALAB 519 -30.615-40:058-723081.0045.73 B

ATOM 9135 C ALAB 519 -31.936-40.913 -70.367^" 1.00_45.67 B

ATOM 9136 O ALAB 519 -3.1.295 -41.952 -70.168 l.GO 44.44 B

ATOM 9137 N GLY B 520 -32.5S7-40.261 -69.4061.0046,13 B ATOM 9-138 CA GLYB 520 -32.587-40.746-68.043 1.0045.94 B

ATOM 9139 C GLY B 520 -31.226-40.641-67.4001.0046.09 B

ATOM 9140 O GLYB 520 -30.933-41.348-66.444.1.0047.09 B

ATOM 9141 N TYRB 521 -30.380-39.764-67.9221.0045.72 B

ATOM 9142 CA TYRB 521 -29.045-39.583-67.363 1.0045.05 B ATOM 9143 CB TYRB 521 -28.123-38.926-68.3871.0044.64 B

ATOM 9144 CG TYRB 521 -26.781-38.542-67.815 1.0044.61 B

ATOM 9145 CDl TYRB 521 -25.803-39.504-67.573 1.0043.93 B

ATOM 9146 CEl TYRB 521 -24.570 -39.153 -&7.0271.0044.61 B ATOM 9147 CD2 TYR B 521 -26.497-37.213-67.493 1.0045:06 B

ATOM 9148^" CE2 TYRB 521 -25.268 -36.853 -66.940 1.0045.30 B

ATOM 9149 CZ TYRB 521 -24.309-37.825-66.7101.0045.07 B

ATOM 9150 OH TYRB 521 -23.098-37.470-66.153 1.0044.80 B

ATOM 9151 C TYRB 521 -29.056-38:737-66.0861.0044.42 B ATOM 91520 TYRB.521 -29.832-37.784-65.9491.0042.65 B

ATOM 9153 N ALA B 522 -28.178 -J9:105 -65.159 1.0044.29 B

ATOM 9154 CA ALA B 522 -28.043-38.418 -63.8821.0044J69 B

ATOM 9155 CB ALA B 522 -28.689-39.239-62.7701.0043.82 B

ATOM 9156 C ALA B 522 -26.557-38.237-63.6061.0045.12 B ATOM 9157 O ALAB 522 -2O39-39.198-63.3121.0046.18 B

ATOM 9158 N GLYB 523 -26.101-36.993-63.7171.004419 B

ATOM 9159 CA GLY B 523 -24.703-36.687-63.4841.0043.20 B

ATOM 9160 C GLY B 523 -24.335-35.406-64.198.1.0042.05 B

ATOM 9161 O GLY B 523 -25.189-34.803-64.848 1.0043.08 B ATOM 9162 N PRO B 524 -23.072-34.966-64.1101.0040.59 B

ATOM 9163 CD PRO B 524 -21.956 -35.701 -63.491 1.0040.63 B

ATOM 9164 CA JPR.O-&-524 -22.595 -33.736 -64:258 1-.0039.16. B

ATOM- 91-65 CB PJRΘB-524 -21.091 -33.-772 -64.5.03 1.00.4Θ763 B

ATOM^" 9166 CG-PRO B 524 -20.967-34.606-63.253 1.0041.18 B ATGM= 916-7-C JBROB524- -22:917-33.741-66.2521.0037.72 B

-ATOM 916&-O PRO B 524 -22.592-34:702-66,950- 1.0038.1O B

ATOM 9169 N JLEUB-525- -23.53F-32.671 -66.7441-0034.78 B

ATOM 9170 CA LEU B 525 -23.897-32.588-68.158 1.00 J2.42 B

ATOM 9171 CB LEU B- 525 -24.46.6-31.211-68.471 1.0029.91 B ATOM 9172 CG LEUB 525 -24.940-31,039-69.906 1.0028.12 B

ATOM 9173 CDl LEU B 525 -26.046-32.026-70.201 1.0026.21 B

ATOM 9174 CD2 LEU B 525 -25.423-29.620-70.110 1.0027.46 B

ATOM 9175 C LEUB 525 -22.768-32.904-69.1521.0033.07 B

ATOM 91760 LEU B 525 -23.008-33.528-70.180 1.0033.67 B ^

ATOM 9177 N HIS B 526 -21.546-32.483-68.842 1.0033.51 B

ATOM 9178 CA HIS B 526 -20.404-32.712-69.7201.0032.83 B

ATOM 9179 CB HIS B 526 -19.246-31.789-69.3361.0031.13 B

ATOM 9180 CG HIS B 526 -18.605-32.124-68.023 1.0030.45 B ATOM 9181 CD2HISB526 -17.429-32.736-67.7381.0030.42 B

ATOM 9182 NDl HIS B 526 -19.182-31.820-66.8091.0029.05 B

ATOM 9183 CEl HIS B 526 -18.389-32.229-65.8341.0029.84 B

ATOM 9184 NE2 HIS B 526 -17.319-32.789-66.371 1.0028.52 B

ATOM 9185 C HIS B 526 -19.896-34.150-69.751 1.0034.47 B ATOM 9186 O HIS B 526 -18.989-34.472-70.5181.0034.99 B

ATOM 9187 N GLNB 527 -20.459-35.012-68.9151.0035.97 T3

ATOM 9188 CA GLN B 527 -20.031-36.406-68.8871.0037.56 B

ATOM 9189 CB GLNB 527 -19.649-36.826-67.462 1.0037.51 B

A-TQM 9190 CG GLN B 527 -18.268 -36.349 -67.031 1.0038.67 B ATOM 9191 CD GLNB 527 -17.972-36.617-65.562 1.0038:20 B

ATOM 9192 OEl GLNB 527 -18.654-36.109-64.671 1.0037.63 B

ATOM 9193 NE2 GLNB 527 -16.946-37.414-65.3071.0038.79 B

ATOM 9194 C GLN B 527 -21.132-37.307-69.425 1.0037.97 B

ATOM 9195 O GLNB 527 -21.013-38.527-69.4191.0037.89 B ATOM 9196 N CYS-B 528 -22.203 -36.688 -69.901 1.0039.00 B

ATOM 9197 CA CYS B 528 -23.329-37.419-70.4481.0039.94 B

ATOM 9198 C CYS B 528 -22.985 -38.034 -71.8Φ21.0041.02 B

ATOM 9199 O CYS B 528 -22.122-37.529 -72.519- J.00-42.11 B-

AIQM 9200 CB CYS B 528 -=24.524 -36.483 -70:5791.0040.12 B ATOM 9201 SG CYS-B.528 -25.772 -37.0-71-71.751 lΛ0.β9τ79 B

ATOM 9202 N ASPB-529^" -23.649 -39.119-72.1481.0041.49- B-

ATQM 9203- CA ASP B 529 -23.387 -39r901 -73.346- T70ΪL41773^" -B

ATOM 9204 CB ASP B 529 -22.334-40.949-73.0951.0041.93 B

ATOM 9205 CG ASP B 529 -22.005-41.752-74.2971.0043.45 B ATOM 9206 ODl ASP B 529 -22.812-41.881-75.1751.0043.9-0 B

ATOM 9207 OD2 ASP B 529 -20.941 -42.297 -74.4691.0044.10 B

ATOM 9208 C ASP B 529 -24.636-40.598-73.7091.0041.00 B

ATOM 9209 O ASP B 529 -24.943-41.558-73.1591.0040.67 B

ATOM 9210 N VALB 530 -25.358-40.050-74.681 1.0041.16 B ATOM 9211 CA VALB 530 -26.695-40.528-75.0071.0042.10 B

ATOM 9212 CB VAL B 530 -27.625-39.370-75.413 1.0041.83 B

ATOM 9213 CGl VAL B 530 -26.966-38.030-75.1191.0042.47 B

ATOM 9214 CG2 VAL B 530 -27.998-39.477-76.883 1.0042.04 B ATOM 9215 C VAL B 53.0- -26.646-41.546-76.140 1.0043.41 B

ATOM 9216 O VAL B 530 -27.640-41.770-76.830 1.0043.67 B

ATOM 9217 N TYRB 531 -25.481-42.159-76.326 1.0043.89 B

ATOM 9218 CA TYRB 531 -25.403-43.472-76.9541.0043.41 B

ATOM 9219 CB TYRB 531 -24.105 -44:180-76.5641.0043.32T B ATOM 9220 CG TYRB 531 -23.649-45.214-77.5691.0044.62 B

ATOM 9221 CDl TYRB 531 -24.058-45.149-78.8941.0044.33 -3

ATOM 9222 GEl TYRB 531 -23.646 -46.091 -79.817 1.0044.72 B

ATOM 9223 CD2 TYR B 531 -22.811-46.255-77.193 1.0046.25 B

ATOM 9224 CE2 TYRB 531 -22.393-47.202-78.108 1.0045.30 B ATOM 9225 CZ TYRB 531 -22.S12 -47.116 -79.419 LOO 45.39 B

ATOM 9226 OH TYRB 531 -22.400-48.055-80.335 1.0045.06 B

ATOM 9227 C TYRB 531 -26.603-44.330-76.5721.0043.74 B

ATOM 9228 O TYRB 531. -26.868-44.554-75.3901.0044.88 B

ATOM 9229 N ARGB 532 -27.327-44.806-77.5791.0044.19 B ATOM 9230 CA ARG B 532 -28.136-46.010-77.435 1.0042.66 B

ATOM 9231 CB ARGB332 -27.399-47.052-76.591 1.0041,41 B

ATOM 9.232 CG ARGB 532 -26.596 -48.055 -77..4041.0042.19 B

ATOM- 9233 CD ARG B 532 -25.750-487998-76.5641.0042.55 B

ATOM -9234 NE^" ARGB 532._ -24.901 -49.854 -77.388 1.00^"44.25 B ATOM 9235 CZ ARG B532 -23,822 -50.484 -76.9441.00<44.06 3

ATΘM 9236 NHl ARG 6^532 -.23.._453 -50.357 -75-677^" 1.0043.47^" B

ATOM 9237 NH2 ARG-B 532 -23.109-51.242-77.765 1.0043.70 B

ATOM! 9238 C ARGB 532 -29.489-45.692-76.8091,0042.07 B

ATOM 9239 O ARGB 532 -30.374-46.545-76.7601.004-1.79 B ATOM 9240 N SERB 533 -29.646-44.461-76.3321.0042.65 B

ATOM 9241 CA SERB 533 -30.914-44.028-75.765 1.0044.70 B

ATOM 9242 CB SERB 533 -30.776-42.743-74.9551.0045.18 B

ATOM 9243 OG SERB 533 -32.059-42.348-74.483 1.0045.26 B

ATOM 9244 C SER B 533 -31.946-43.801-76.8471.0045.55 B ATOM 9245 O SERB 533 -31.852-42.858-77.635 1.0047.55 B

ATOM 9246 N THR B 534 -32.940-44.672-76.868 1.0045.40 B

ATOM 9247 CA THR B 534 -34.005-44.597-77.838 1.0045.28 B

ATOM 9248 CB THR B 534 -34,758-45.927-77.8771.0046.07 B ATOM 9249 OGl THRB 534 -35.357-46.174-76.599 1.0047.88 B ATOM 9250 CG2 THR B 534 -33.788-47.064-78.1821.0047.47 B

ATOM 9251 C THRB 534 -34.954-43.465-77.4691.0044.80 B

ATOM 92520 THRB 534 -35.417-42.726-78.331 1.0045.81 B

ATOM 9253 N ALAB 535 -35.229-43.323-76.178 1.0044.74 B ATOM 9254 CA ALA B 535 -36.131-42.276-75.701 1.0045.42 B

ATOM 9255-CB ALA B 535 -36.157-42.263-74.1681.0045.33 B

ATOM- 9256 C ALA B 535 -35.691 -40.913 -76.2301.0045.60 JB

ATOM 9257 O ALAB 535 -36.518-40.092-76.6421.0045.53 B

ATOM 9258 N ALAB 536 -34.382 -40 J680 -76.201 1.00:45.33 B ATOM -9259 CA ALA B 536 -33.813- -39.431 -76.685 1.0.043.Sl B

ATOM 9260 CB ALA B 536 -3.2.330-39.364-76.328 1.0043.05 B

ATOM 9261 C ALA B 536 -33.994-39.403-78.1991.0042.79 B

ATOM 9262 O ALAB 536 -34.628-38.491-78.7491.0042.43 B

ATOM 9263 N GLYB 537 -33.432-40.421-78.853 1.0Θ-40.60 B ATOM 9264 CA GLYB 537 -33,508 -40.541 -80.2971.0035.20 B

ATOM 9265-C GLYB.537 -34.875-40.192-80.841 LOO 37.15 B

ATOM" 9266 O -GLYB 537 -34,992.-39.539-81.8721.60-38.07 B.

ATOM 9267 N ALAB 538 -35τ9-16 -40.625 -80.1461.0035.56 B

ATOM 9268 CA-ALA-B 538- -37.274 -4ft347 -80.577 L.aθ-35.02 B A^FOM 9269 CB ALA B 538 -38.250 -41.122 -79.731 1.0.034.00 B

ATOM 9270-e ALAB 538: -37.567 -38.8M-80.46Θ 1.0035^84- ^B

ATOM 9271 O ALAB 538 -38.276-38.293 -81.293 1.00-35.04 B

ATOM- 9272 N LYS B 539 -37.008-38.2-47-79.4201.0036.90 B

ATOM 9273 CA LYS B 539 -37.229-36,834-79.158 1.0037.61 B ATOM 9274 CB LYS B 539 -36.785 -36.484 -77.748 1.0037.68 B

ATOM 9275 CG LYS B 539 -37.325 -35.153 -77.2901.0038.82 B

ATOM 9276 CD LYS B 539 -37.022 -34.927 -75.8461.0037.41 B

ATOM 9277 CE LYS B 539 -37.849-33.800-75.321 1.0037.90 B

ATOM 9278 NZ LYS B 539 -37.545-33.648-73.889 1.0041.26 B ATOM 9279 C LYS B 539 -36.514-35.939-80.145 1.0038.60 B

ATOM 9280 O LYS B 539 -36.936-34.803-80.385 1.0039.30 B

ATOM 9281 N LEU B 540 -35.422-36.450-80.704 1.0038.46 B ATOM 9282 CA LEU B 540 -34.658 -35.706 -81..689 1.003831 B ATOM- 9283. CB LEUB 540 -33.263-36.317-81.8271.0037.68 B ATOM 9284 CG LΕU B ^"540 -_32.1€8-35.507 -82.5261.0036.73 B ATOM 9285 CDl LEU B 540 -30.876-36.308-82.5421.0034.95 B ATOM 9286 CD2 LEU B 540 -32.587-35.171-83.928 1.0037.09 B

ATOM 9287 C LEU B340 -35.424 -35.847 -82.9971.Θ039.52 B ATOM 9288 O LEU B 540 -35.719-34.869-83.680 1.0038.79 B

ATOM- 9289 N ARGB 541 -35.804 -37.036 -83.323 1.0040.81 B- ATOM 9290 CA ARG B.541 -36.4-74-37.257-84.534 1.0043.05 B ATOM 9291 CB ARG B 541 -36.525-38.707-84.7441.0045.77 B ATOM 9292 CG- ARG B 541 -37.542-39.157-85.658 1.0050.04 B- ATOM 9293-CD ARG^"B 541 -37.738-40.620-85.532 1.0054:31 B ATOM 9294 NE ARGB 541 -38.069-41.293-86.763 1.0058.25 B ATOM 9295 CZ ARG B 541 -39.269-41.353-87.265 1.0060.29 B ATOM 9296 NHl ARGB 541 -40.273-40.754-86.653 1.0061.29 B ATOM 9297 NH2 ARGB 541 -39.456-42.009-88.3871.0060.44 B ATOM 9298 C ARGB 541 -37.808-36.696-84.612 1.0042.73 B

ATOM 9299 Q ARGΕ 54i -38.425 -36.728 -85.6X)8 1.0042.92 B

ATOM JSDO-N LYS B 542^" -38:208-36,008-83,5971.00-42 JO B

ATOM -9301 CA. LYS B 542 -35r456 -35.347 -83.691 1.0042.00 B

ATOM 9302 CB LYS B 542 -40.104 -35r262^82J461.0042.16- a ATOM-93Θ3 CG -LYS B 542- -41.526 -34.959^"-82.458 1.0043.66 B

ATOM 9304 CD LYS B 542 -4Z232-35-.144-8U84-T.0ft44.42 B

ATOM^" 9305 XEJLYS B 542 -43.296 -36.227--8Ϊ.2640.0044.38- B

ATOM 9306 NZ LYS B 542 -43J.-21 -37.347-80.3200.0044.44 B-

ATOM 9307 C LYS B 542 -39.256-34.009-84.218 1.0041.40 B ATOM 9308 O LYS B 542 -40.162-33.383 -84.678 1.0039J89 B

ATOM 9309 N VAL B 543 -38.046-33.535-84.0501.0041.23 B ATOM 9310 CA VAL B 543 -37.699-32.222-84.581 1.0041.54 B ATOM 9311 CB VAL B 543 -36.616-31.513-83.7061.0041.24 B ATOM 9312 CGl VALB 543 -36.943-31.701-82.235 1.0040.72 B 0

ATOM 9313 CG2VALB543 -35.224-32.041-84.028 1.0040.69 B

ATOM 9314 C VAL B 543 -37.194-32.320-86.015 1.0042.22 B

ATOM 9315 O VAL B 543 -37.392-31.398-86.819 1.0041.84 B

ATOM 9316 N LEUB 544 -36.537-33.434-86.334 1.0041.99 B ATOM" 9317 CA LEUB 544 -36:025 -33.62fr-87.682 1.0O 41.18 B

ATOM 9318 CB LEUB 544 -35.145-34.884-87.7551.0040:00 B

ATOM 9319 CG LEUB 544 -33.866-34.898-86.903 1.0038.85 B

ATOM 9320 CDl LEU B 544 -33.027-36.118-87.248 1.0037.50 B

ATOM 9321 CD2LEUB544 -33.057-33.637 -87.H3 1.0038.14 B ATOM 9322 C LEU-B 544 -37.201 -3.3.736 -8^.6561.0041.36 B

ATOM 9323 O LEUB 544 -37.219 -33.07S--89.69-31:0041:57 B

ATOM 9324 N GLN B- 545 -38.202-34.486-88.3001.0040:59 B

ATOM 9325 CA GLN B 545 -39.337-34.684-89.1001.0039.73 B

ATOM 9326 CB GLN B 545 -40.209-55.706-88.423 1.0041.89 B ATOM 9327 CG GLN B 545 -39:849-37.136-88.6741. -0046.21 B

ATOM 9328 CD GLN B 545 -4L006 -38.128 -88.645 LOO 48.75 B

ATOM 9329 OEl GLNB 545 -42.107-37.847-89.0401.0051.68 B

ATOM 9330 NE2 GLN B 545 -40.717-39.302-88.205 1.0049.55 B

ATOM 9331 C GLN B 545 -40.146-33.461-89.2751.0038.06 B ATOM 93320 GLN B 545 -41.064-33.457-90.013 1.0038.59 B

ATOM 933θ N ALA B 546 -35,883 -32.441 -887513 1.0035.44 B-

ATOM 9334-CAALAB546 -40.63? -31.-198 -88.5751700-34.68 B

ATOM 9335 CB, ALA-B 546 -4Gr49« -30.444 -87.275 1.0034.1-7 B

ATΘM 933^~β^~C ALA B 546 -40.173.-30.324-89.7291.0035.23 B ATOM 9337 O ALA B 546 -4O7-903--297441-90.189 1:ΘO34J2 B.

ATOM 9338 N^" GLYB 547 -3&S49-30.572 -90.1871.003538 B^"

ATOM 9339- CA-GLY-B 547 -38395-29-.79.4-94.2771.0034.1O B'

ATOM 9340 C GLY B.547 -38.598 -28.323 -9T.005 1.0034.-70- B

ATOM 9341 O GLYB 547 -38.332-27.857-89.901 1.0035.67 B ATOM 9342 N SER B 548 -39.091-27.602-92.005 1.0034.84 B

ATOM 9343 CA SERB 548 -39.333-26.167-91.9071.0034.96 B

ATOM 9344 CB SERB 548 -38.818-25.481-93.1871.0034.80 B

ATOM 9345 OG SERB 548 -39.393-24.200-933891.0034.71 B

ATOM 9346 C SER B 548 -40.818-25.866-91.7061.0035.15 B ,,.

361

ATOM 93470 SERB 548 -41.233-24.704-91.6691.0034.34 B

ATOM 9348 N SER B 549 -41.608-26.926-91.5581.0036.34 B

ATOM 9349 CA SERB 549 -43.060-26.813-91.3941.0037.58 B

ATOM 9350 CB SERB 549 -43.666-28.194-91.1561.0036.22 B ATOM 9351 OG SERB 549 -43.208 -28.741 -89.9371.00-34.83 R

ATOM 9352 C SER B 549 -43.517-25.882-90.281 1.0039.04 B

ATOM 9353 O SER B 549 -44.216-24.894-90.5271.0040.78 B

ATOM 9354 N ARGB 550 -43.126-26.210-89.055 1.0039.83 B

ATOM 9355 CA ARGB 550 -43.503-25.431-87.8771.0040:30- B ATOM 9356 CB ARGB 550 -43.785-26.393-86.711 1.0041.73 B

ATOM 9357 CG ARG B-550 -45.120-27.133 -86Ϊ788 1.00-42.48 B

ATOM 9.358 CD ARGB 550 -45.097 -28.47.5 -86.034 LOO 4.4.37 B

ATOM 9359 NE ARG B 550 -44.605-28.407-84.6521.0045.71 B

ATOM 9360 CZ ARG B 550 -45.134-27.652-83.6841.0046.59 B ATOM 9361 NHl ARG B 550 -46.187-26-874-83.925 1.0046.42 B

ATOM 9362 NH2 ARG B 550 -44.614-27.682-82.463 1.0046.01 B

ATOM 9363 C ARG B 550 -42.438-24.414-87.4501.0039.32 B

ATOM 93640 ARG B 550 -41.247-24.611-87.7001.0038.55 B

ATOM 9365 N PRO B 551 -42.864-23.306-86,8071.0038.36 B ATOM 9366 CD PROB 551 -44.272-22.908-86.6161.0037.54 B

ATOM 9367 CA PROB 551 -41.963 -22.249 -86.326 lvQΘ38.49- B

ATOM 9368 CB EROB 551 -42.9.12-21.301-85.603 1.0036.«? B-

AIOM 9369 CG- PRO B 551- -44.163. -2L414 -86_^4071.0036?45 B

ATOM 9370 C PROJBL5:51 -40.937^22.869-85.375 1.00^9.19 -B^~ ATOM 93-7-1 O -PROB 551 -41.31-7-23.573-84.4381.0039:93- B^~

ATOM 9372 N TBSU-*552 -39:649-22.610-8-5.601 IM 39SZ B

ATOM 9373 CA TRP B 552 -38.609-23.203-84.7641.0040:91^" B

ATOM 9374 CB TRP B- 552 -37.221 -22.657 -S5.L19 1.0041.54 -B

ATOM 9375 CG TREB 552 -37.000 -21.210 --84.799 1:0041.96 B ATOM 9376 CD2 TRP B 552 -36.558-20.663-83.548 1.0042.33 B

ATOM 9377 CE2 TRP B 552 -36.489 -19.260 -83.7071.0042.24 B

ATOM 9378 CE3 TRP B -552 -36.211-21.222-82.306 1.0042.04 B

ATOM 9379 CDl TRP B 552 -37.176-20.151-85.6361.0042.23 B

ATOM 9380 NEl TRP B 552 -36.870-18.975-84.991 1.0041.99 B .,_

3 OZ

ATOM 9381 CZ2TRPB552 -36.092-18.407-82.670 1.0041.35 B

ATOM 9382 CZ3 TRP B 552 -35.816-20.371-81.2761.0041.07 B

ATOM 9383 CH2TRPB552 -35.762-18.981-81.4671.0041.33 B

ATOM 9384 C TRP B 552 -38.849-23.023 -83.2721.004L60 B ATOM 9385 O TRP B 552 -38.692-23.972-82.4981.0040.75 B

ATOM 9386 N GLNB^~553 -39.231-21.811-82.8671.0041.74 B

ATOM 9387 CA GLN B 553 -39.477-21.549-81.459 1.0041.46 B

ATOM 9388 CB GLN B 553 -40.053-20.144-81.246 1.0041.48 B

ATOM 9389 CG GLN B-553 -40.756-19.516-82.4401.0043.02 B ATOM 9390 CD GLN B 553 -39.816-18.736-83.351 1.0042.89 B

ATOM 9391 OEl GLN B 553 -39.133.-17.804 -82.916 1.0041.39 B

ATOM 9392 NE2 GLN B 553 -39.787 -19:1 H -84.6271.0043.95 B

ATOM 9393 C GLN B 553 -40.406-22.598-80.8741.0040.95 B

ATOM 9394 O GLNB 553 -40.186-23.075-79.7661.0041.42 B ATOM 9395 N GLUB 554 -41.430-22.^79-81.623 1.0040.55 B

ATOM 9396 CA GLU B 5-54 -42.360 -23.989 -8L1401.0041.57 B

ATOM 9397 CB GLU B 554 -43.593 -24.071 -82.033 l.OQ 44.40 B

ATOM 9398 CG GLU B-554 -44.258 -22.733 -82.3081.0049.0& B

ATOM 9399 CD GLU B 554 -45.686-22.883-82.8141.0051.48 B ATOM 9400 OEΪ-GLUB554 -45.991-23.924-83.458 1.0052.76 B

ATOM 9401 OE2GLUB554 -46.494-21.949-82.582 1.0052.45 B

ATOM 9402 C GLU B 554 -41.705-25.357-81,096 1.004133 B

ATOM 9403 O GLUB 554 -41.872-26.09-9-80.137 h0041.90- B

ATOM 9404 N VALB 555 -40:964-25,698-82:1421.00=40.65 ^~B ATOM 9405 CA VAL B-555 -40.3e3-26i999--82.2001.0040.46 B

ATOM 9406 CB VAL B 555 -39.546 -27.175 -83.546- 1.0039.82- B

ATOM 9407 CGl VAL B 555 -38^69^28.577=83.65-1 1.00-37.64 B

ATOM 940S- CG2 VAL B 555 -40.490 -26.899 -84.7071.0038.94 B

ATOM 9409 C VAL-B 555 -39.330 -27.158 -8L0281.0041.07 B ATOM 9410 O VAL B 555 -39.159-28.249-80.485 1,0040.66 B

ATOM 9411 N LEUB 556 -38.704-26.051-80.6421.0042.08 B

ATOM 9412 CA LEU B 556 -37.751-26.035-79.5331.0042.18 B

ATOM 9413 CB LEUB 556 -36.963-24.720-79.5481.0040.79 B

ATOM 9414 CG LEU B 556 -35.702-24.591-78.6971.0039.16 B ^

ATOM 9415 CDl LEUB 556 -34.668-25.624-79.1141.0036.71 B

ATOM 9416 CD2 LEUB 556 -35.159-23.184-78.863 1.0038.53 B

ATOM 9417 C LEUB 556 -38.490-26.187-78.1971.0042.32 B

ATOM 9418 O LEUB 556 -38.120-27.013-77.3641.0042.99 B ATOM 9419 N LYS B 557 -39.536 -25.394 -77.9971,0041.86 B

ATOM 9420 CA LYS B 557 -40.301 -25.475 -76.7641.0042.72 B

ATOM 9421 CB LYS B 557 -41.511-24.549-76.833 1.0042.86 B

ATOM 9422 CG LYS B 557 -42.187-24.313-75.501 1.0041.90 B

ATOM 9423 CD LYS B 557 -43.100-23.101-75.5901.0043.98 B ATOM 9424 CE LYS B 557 -43.600 -22.685 -74.215 1.0045.14 B

ATOM 9425 NZ LYS R 557 -44.336-21.387-74.259-1.0046.16 B

ATOM 9426 C LYS B 557 -40.-760-26.908-76.5261,0043.36 B

ATOM 94270 LYS B 557 -40.939-27.328-75.391 1.0044.94 B

ATOM 9428 N ASP B 558 -40.940-27.653-77.610- 1.0043.75 B ATOM 9429 CA ASP B 558 -41.377-29.044-77.5541.0043.67 B

ATOM 9430 CB ASP B 558 -41.906 -29.4.85 -78.9221.0045.68 B

ATOM 9431 CG ASPB 555 -43.327-29.014-79.2001.0047.53 B

ATOM 9432 ODl ASP B 558 -43.693-27.879-78.8-181.0047.92 B

ATOM 9433 ΘD2ASPB558 -44.€79 -29.785 -79.832 1.0048.33 B ATOM 9434 C ASP B 558 -40.230-29.965-77.1861.0043.45 B

ATOM 9435 O ASP B 558 -40.417 -30.967-763091.0043.98 B

ATOM 9436 N MET B 559 -39:037-29.623-77.645 L0.0-43.o5 B

ATOM 9437 CA MET B 559 -37.869 -3.0.452 -77.407 LOO 43.88- B

ATOM 9438_CB-METB559 -36:921 -30.336 -78396 T.00-42.76 B ATOM^" 9439 CG METB 559 -35.850--31.392 -78τόlO LfiO.42.98 B

ATOM 944$ SD METB359 -34.292-30.788-79293 1.0043.98 B

ATOM 944-1 CE MET-B 559 -33.261 -32.319-79.185 LOO 43.17 B^"

ATOM 9442 C METB 559 -37.103-30.142-76.1221.0044.24. B

ATOM 94430 MET B 559 -36.752-31.044-75.3661.0043.9-1 B ATOM 9444 N VAL B 560 -36.837-28.868-75,878 1.0044.67 B

ATOM 9445 CA VAL B 560 -36.090 -28.474 -74.7001.0044.60 B

ATOM 9446 CB VAL B 560 -35.014-27.408-75.0671.0046.65 B

ATOM 9447 CGl VAL B 560 -34.134-27.076-73.842 1.0048.47 B

ATOM 9448 CG2 VAL B 560 -34.151-27.930-76.221 1.0046.35 B ATOM 9449 C VAL B 560 -37.024-27.921-73.6371.0043.58 B

ATOM 9450 O VAL B 560 -36.671-27.851-72.4641.0043.72 B

ATOM 9451 N GLYB 561 -38.227 -27.543 -74.050 LOO 42.97 B

ATOM 9452 CA GLY B 561 -39.175-26.989-73.102 1.0043.40 B ATOM 9453 C GLY B 561 -38.984-25.490-72.960 LOO 43.70 B

ATOM 9454 O GLYB 561 -39.545 -24.842 -72.075 1.0043.63 B

ATOM 9455 N LEU B 562 -38.185-24.926-73.849 1.0044.34 B

ATOM 9456 CA LEU B 562 -37.938-23.505-73.796 1.0044.94 B

ATOM 9457 CB LEU B 562 -36.482 -23.248 -73.417^" 1.0045.28 B ATOM 9458 CG LEUB 562 -36.195-21.829-72.930 1.0043.60 B

ATOM 9459 CDl LEU B 562 -36.964-21.569 -7L6441.0041.74 B

ATOM 9460 CD2 LEU B 562 -34.698 -21.664 -72.2271.0043.26 B

ATOM 9461 C LEUB 562 -38.274-22.830-75.1181.0045.27 B

ATOM 9462 O LEUB 562 -38.055-23378-76.193 1.0046.05 B ATOM 9463 N ASPB 563 -38.785 -2US15 -7-5.005 1.0045.84 B

ATOM 9464 CA ASP B 563 -39.214-20.806-76.1341.0045.70 B

ATOM 9465 CB ASP B 563 -40.m-19J724-75.6041.0047.47 B

ATOM 9466 CG ASP B 563 -41.091-19.204-76.6541.0048.52 B

ATOM 9467 ODl ASP B 563 -40.656-19.056-77.813 1.0049.#7 B ATOM 9468 OD2ASPB563 -42.266 -18.930-76.313 1.0049.97 B

ATOM 9469 C ASP B 563 -38.108-20,141-76.9661.0045.48 B

ATOM 9470 Θ ASP B 563 -38.404-19:454 -77:943 1.0044.95 B

ATOM 9471 N ALAB 564 -36.843 -20,318 -76.5941.0044.65 B. ATOM- 9472 CA ALA--B1564 -35.78ft -±9:681-77.363 1.0043.57 B ATOM 9473 CB ALA B 564 -35.87-6 -1&169 -77.218 1.0041.57 B

ATOM 9474^{" Q} ALA B 564 -34.371 -20^".14O -77.023- 4.0σ 43.39 ^"B

ATOM 9475 O ALA B 564 -34.1-74-21.123-76.3071.0042.91 B

ATOM 9476 N LEUB 565 -33.395-19.421-77.575 LOO 43.52 B

ATOM 9477 CA LEU B 565 -31.984-19.704-77.3461.0042.78 B ATOM 9478 CB LEUB 565 -31.114-18.885-78.293 1.0043.31 B

ATOM 9479 CG LEUB 565 -30.926-19.410-79.713 1.0044.36 B

ATOM 9480 CDl LEU B 565 -30.538-18.247-80.631 1.0043.32 B

ATOM 9481 CD2LEUB565 -29.864-20.513-79.721 1.0044.16 B

ATOM 9482 C LEUB 565 -31.639-19.329-75.9171.0042.36 B , ,.

JOJ

ATOM 9483 O LEUB 565 -32.105-18.310-75.4021.0042.15 B

ATOM 9484 N ASP B 566 -30.747 -20.072 -75.2921.0041.59 B

ATOM 9485 CA ASP B 566 -30.422-19.881-73,8921.0040.71 B

ATOM 9486 CB ASP B 566 -31.421-20.701-73.1061.0043.28 B ATOM 9487 CG ASP B 566 -31.583-20.296-71.680 1.0045.99 B AT©M 9488 ODJ ASP B 566 -31.676-19.118-71.370 1.0047.94 B ATOM 9489 OD2ASPB566 -31.697-21.117-70.7901.0046.40 B

ATOM 9490 C ASP B 566 -29.025-20.373-73.675 1.0039.12 B

ATOM ^"9^"49I O ASFB 566 -28.688-21.408-74.166 1.0038.39 B ATOM 9492 N ALA B 567 -28.206-19,604-72.9661.0036.51 B ATOM 9493 CA ALA-B 567 -26.825-19:959-72.6861.0034.54 B ATOM 9494 CB ALA B 567 -25.987-18.70-1 -72.511 1-.0034.47 B

ATOM 9495 C ALA B 567 -26.694-20.827-71.4561.0032.42 B

ATOM 9496 O ALA B 567 -25.744-21.588-71.3371.0031.96 B- ATOM ^"9497 N ALA B 568 -27.654 -20.716 -70.5491.00 J0.75 B ATOM 9498 CA ALA B 568 -27.613-21.465-69.3071.0030.06 B ATOM 9499 CB ALA B 568 -29.004-21.561-68.7171,0030.45 B

ATOM 9500 C ALA B 568 -26.992 -22.850 -69.456 1.0029.43 B

ATOM 9501 O ALA B 568 -26.057-23.192-68.729 1.0030.56 B ATOM 9502 N PRO B 569 -27.487-23.661-70.405 1.0028.00 B

ATOM 9503 CD PRO B 569 -28JS72 -23.498 -71.261 1.0026.75 B

ATOM 9504 CA PRO B 569 -26.905 -24;-996 -70.568 l.θθ 27.45 B

ATOM 9505 CB PROB-569 -27.845 -25.66S -71.5681.0025.54 B

ATOM 95Θ6 CG PRO B 569- -28,440-24.537-72.3116.1.0026.33 Bz ATOM 9507 C ERO B 569 -25.439 -25.008 -71.0041.0(T27:80 B

ATOM 9508--O TdRO B569 -24.677 -25.SS6 -70.605 1.0028.41 ^~R

ATOM 9509 N LEU B 570 -25.038-24.041-71.821 1.0027.61 B

ATOM 9510 CA LEU B 570 -23.645-23.976-72.2491.0027.21 B

ATOM 9511 -CB LEUB 570 -23.431-22.784-73.201 1.0027.74 B ATOM 9512 CG LEUB 570 -22.006-22.359-73.5971.0027.63 B ATOM 9513 CDl LEU B 570 -21.243-23.520-74.1241.0028.50 B ATOM 9514 CD2 LEU B 570 -22.056-21.294-74.658 1.0029.91 B

ATOM 9515 C LEUB 570 -22.833-23.797-70.975 1.0026.65 B

ATOM 9516 O LEUB 570 -21.963-24.606-70.655 1.0026.01 B ATOM 9517 N LEUB 571 -23.158-22.726-70.2541.0025.90 B

ATOM 9518 CA LEUB 571 -22.535-22.355-68.9871.0024.40 B

ATOM 9519 CB LEUB 571 -23.381-21.293-68.303 1.0023.30 B

ATOM 9520 CG LEU B 571 -23.511-19.988-69.0801.0021.97 B ATOM 9521 CDl-LEU R571 -24.700 -19.192 -68.587 LOO 21.87 B

ATΘM 9522 CD2-LEU B 571 -22.227 -19.211- -68:9371.0022.23 B

ATOM 9523 C LEU B 571 -22.449-23.569-68.0941.0025.57 B

ATOM 9524 O LEU B 571 -21.401-23.863-67.5261.0027.22 B

ATOM 9525 N LYS B- 572 -23.557-24.236-67.853 1.0025.43 B ATOM 9526 CA LYS B 572 -23.571 -25.527 -^"67.2M 1.0025.99 B

ATOM- 9527 CB LYS B 572 -24.9-14 -26J3T -67.286- 1.0027.30 B

ATOM -9528.CG LYS B 572 -25.717 -26.086 ,66.0301.0029.46- B

ATOM 9529 CD LYS B 572 -27.086-26.533-66.2001.0031.79 B

ATOM 9530 CE LYS-B372 -27.006 -27.962 -66.4901.0034.66 B ATOM 9531 NZ LYSB 572 -28.294-28,650-66.6801.0036.95 B

ATOM 9532 C LYS B 572 -22:684 -26.577 -67.6721.0025.73 B

ATOM 9533 O LYS B 572 -22.296 -27.407 -66.9621.0025.83 B

ATOM 9534 N TYR B 573 -22.449-26.634-68.9341.0026.33 B

ATOM 9535 CA TYR B 573 -21:550 -27.650 -69.4781.0026.13 B ATOM 9536 CB TYRB 573 -21.688-27.723-71.0061.0025.57 B

ATOM 9537 CG- TYR B 573 -20:822-28.778-71.684 1.002123 B

ATOM 9538 CDl TYR BF573- -21.38J =29.963^" -72.1671,0022.27 B

ATΘM 9539 CElTYR B 571 -20.599-30.932-72.7851.0022.02 B

ATOM 9540 CD2TYR-B-573 -19.451 -28.592 -71.833-JLJQ0-2137 B ATOM 9541 CE2TYR-B^~573 -18.662-29.5.-50-72.445 1.0022.44 -B

ATΘM 9T42 CZ JYRB573 -19.241 -30.721 -72.919- 1.00-23.42 B

ATOM 9543 OH TYR B 573 -18.453 -^"3-1.689 -73.499-1.6023.68 B

ATOM 9544 C TYRB-573 -2O.098 -27.371-69.135 1.0026.89 B

ATOM 9545 O TYRB 573 -19.336-28=298-68.863 1.0027.75 B ATOM 9546 N ^"PHE B 574 -19.713 -26.097 -69.15Q 1.0027.60 B

ATOM 9547 CA PHE B 574 -18.325-25.714-68.874 1.0028.47 B

ATOM 9548 CB PHE B 574 -17.906-24.626-69.8681.0026.52 B

ATOM 9549 CG PHE B 574 -17.858-25.096-71.290 1.0024.98 B

ATOM 9550 CDl PHE B 574 -18.891-24.813-72.1661.0023.79 B Jo/

ATOM 9551 CD2PHEB574 -16.769-25.843-71.751 1.0024.23 B

ATOM 9552 CEl PHE B 574 -18.838-25.267-73.473 1.0024.25 B

ATOM 9553 CE2PHEB574 -16.712-26.298-73.051 1.0022.92 B

ATOM 9554 CZ PHE B 574 -17.747-26.010-73.9141.0024.54 ■ B ATOM 9555 C PHE B 574 -17.954 -25.269-67:445 1.0029.90 B

ATOM 95560 PHE B 574 -16.791-24.969 -67.1J63 1.0030.56 B

ATOM 9557 N GLN B 575 -18.868-25.342-66.5171.0031.22 B

ATOM 9558 CA GLN B 575 -18.659-24.866-65.181 1.0032.04 B

ATOM 9559 CB GLN B 575 -19.728-25.367-64_^342 1.0033:24 B ATOM 9560 CG GLN B 575 -20.474-24.353-63.678 1.0035.80 B

ATOM 95^1 CD GLN B 575 -21.736 -24i900 -63.205 1:0038.18- B-

ATOM 9562 OEl GLNB 575 -22.764-24.362-63.4461.0039.54 B

ATOM 9563 NE2 GLN B 575 -21.670-25.998-62.592 1.0037.30 B

ATOM 9564 C GLN B 575 -17.416 -25.158-64.4621.0032.64 B ATOM 9565 O GLN B 575 -16.845 -24.297 -63.921 1.0032.42 B

ATOM 9566 N PRO B 576 -17.011-26.384-64.331 1.0033.33 B

ATOM 9567 CD PRO B 576 -17.632-27.675-64.6961.0034.60 B

ATOM 9568 CA PRO B 576 -15.742 -26.596 -63622 LOO 32.56 B

ATOM 9569 CB PRO B 576 -15.560-28.123-63.6681.0032.95 B ATOM 9570 CG PRO B 576 -16.98:8 -28.640 -63.688 1.0034.40 B

ATOM 9571 C PROR576 -14.550 -25.83J8 -64.2061.003Ol B

ATOM 9572 O PRO B 576 -13.749 -25.281 -6X460^" 1.0032.14 B

ATOM 9573 N VALB 577 -14.430 -25.79S~65r5291.0029.24 B

ATOM 9574 CA-VAETB 577 -13.304-25:099 -66:1341.0027.81 B ATOM 9575 CB VAL B -577 -12.926-25.702-67.5201.0027.99 B"

ATΘML 9576 CGl V-AL B 577 -13.8O9 -25.117 -68,6141.0027.21 B

ATOM 9577 CG2 VAL B-577 -11.458 -25.441 -67.809. LOO 28.79 B

ATOM 9578 C VAL B 577 -13.560-23.600-66.248 1.0026.61 B

ATOM 9579 O VAL B 577 -12,615-22.820-66.3201.0026.68 B- ATOM 958ON THR B 578 -14.829-23.196-66.258 1.0025.36 B

ATOM 9581 CA THR B 578 -15.158-21.772-66.3121.0025.34 B

ATOM 9582 CB THR B 578 -16.674-21.515-66.222 1.0024.71 B

ATOM 9583 OGl THR B 578 -17.300-21.853-67.466 1.0024.56 B

ATOM 9584 CG2 THRB 578 -16.948-20.054-65.8841.0023.51 B , „

ATOM 9585 C THRB 578 -14.530-21.162-65.070 1.0025.97 B

ATOM 95860 THRB 578 -13.907-20.098-65.1161.0026.41 B

ATOM 9587 N GLNB 579 -14.482-21.911-64.031 1.0026.18 B

ATOM 9588 CA GLNB 579 -14.044-21.419-62.7941.0026.59 B

5 ATOM 9589 CB GLNB 579 -14.847-22.022-61.6941.0027.58 B

ATOM 9590 CG GLNB 579 -16.301 -22.007 -61.852 l.Gø 30.99 B

ATOM 9591 CD GLN B 579 -16.905-20.703-61.413 1.0033.74 B

ATOM 9592 OEl GLN B 579 -17.962-20.309-61.8591.0035.85 B

ATOM 9593 NE2 GLN B 579 -16.241-20.050-60.5561.0031.46 B

10 ATOM 9594 C GLN B 579 -12.675-21.717-62.5161.0025:93 B

ATOM 9595 O GLNB 579 -12.055-21.015-61.841 1.0025:67 B

ATOM 9596 N TRP B 580 -12209 -22.853 -62.9491.0O25.70 B

ATOM 9597 CA TRP B 580 -10.791-23.164-62.8341.0024.46 B

ATOM 9598 CB TRP B 580 -10.510-24.574-63.3281.0023.68 B

15 ATOM 9599 CG TRP B 580 -9.074-24.915-63.227 LOO 23.87 B

ATOM 9600 CD2 TRP B 580 -8.101-24.772-64.2591.0025.39 B

ATOM 9601 CE2TRPB580 -6.849-25.107-63.699 LOO 2459 B

ATOM 9602 CE3 TRPB 580. -8.163-24.384-65.6061.0025.83 B

ATOM 9603 CDl TRP B 580 -8.402-25.329-62.1191.0021.44 B

20 ATOM 9604 NEl TRP B 580 -7.065-25.448-62.3901.0023.02 B

ATOM 9605 CZ2TRPB580 -5.665 -25.067 -64.4361.0025.96 -B

ATOM 9606 CZ3 TRP B 580 -6.988 -24345-66.3421..0026.76 B

ATOM 9607.CH2 TRPrB 580 -5.753 -24.682 -65.752 I.θθ-27rl4 B

ATOM 9608 -C TRP B 580 -9.929--22.P70-63.6OX 1.0025.09 B,

J2S -AfFOM -9609 JO. TRP-B 58G- -8.832-21.810-63.1571.0024.52 B

ATOM -9610 N LEUB 581 -WL427 -21.726 -64.758 1.0025.04 -B

ATOM 96-11 CA LEU BS81 -9.708-20.749-65374- h0023.67 B

ATOM 9612 CB LEU B^~581 -10.363-20.622-66.949-1.0022.40 B

ATOM 9613 CG LEU B 581 -9.945 -21.660-68.0001.0020J.8 B

30 ATOM 9614 CDl LEUB 581 -10.807-21.511-69.2471.0017.89 B

ATOM 9615 CD2 LEU B 581 -8.474-21.475-68.335 1.0016.02 B

ATOM 9616 C LEUB 581 -9.701-19.399-64.8721.0023.50 B

ATOM 9617 O LEUB 581 -8.657-18.773-64.715 1.0022.08 B

ATOM 9618 N GLNB 582 -10.881-18.961-64.4541.0024.25 B ATOM 9619 CA GLN B 582 -11.024-17.702-63.7421.0025.06 B

ATOM 9620 CB GLNB 582 -12.451-17.563-63.2091.0023.63 B

ATOM 9621 CG GLN B 582 -13.410-16.829-64.1191.0022.21 B

ATOM 9622 CD GLN B 582 -14.721-16.498-63.4281.0022.21 B

ATOM 9623 OEl-GLNB 582 -15.636-17.311-63.3881.0023.34 B

ATOM 9624 NE2GLNB582 -14.807-15.301-62.866 1.0022.51 B

ATOM 9625 C GLN B 582 -10.048-17.613-62.572 1.0026.72 B

ATOM 9626 O GLNB 582 -9.348-16.612-62.403 1.0027.27 B

ATOM 9627 N GLUB 583 -10.002 -18.663 -61.7551.0027.71 B

ATOM 9628 CA GLU B 583 -9.114-18.674-60.5921.0028.39 B

ATOM 9629 CB GLU B 583 -9.353-19.928-59.7361.0-030.48 B

ATOM ft630 CG GLU B 583 -8.495-19.966-53.4591.0032.33 B

ATOM 9631 CD GLUB 583 -8.895-18.917-57.413 1.0031.99 B

ATOM 9632 OEl GLU B 583 -9J-82 -17.753 -57.775 LOO 31.14 B

ATOM 9633 OE2GLUB583 -8.906-19.258-56.213 1.0033.39 B

ATOM 9634 C GLU B 583 -7.644-18.586-60.9871.0027.12 B

ATOM 9635 O GLUB 583 -.6.882-1-7.849-60.3671.0026.58 B

ATOM 9636 N GLNB 584 -7.252-19.341-62.013 1.0027.45 B

ATOM 9637 CA GLN B 584 -5.875-19.326-62.506 1.0027.16 B

ATOM 9638 CB GLN B 584 -5.723-20.265-63.7041.0027.17 B

ATOM 9639 CG GLN B 584 -5.950-21.739-63.398 1.0030.15 B

^"ATOM- 9640 CD GLN B 584 -4.877-,22.321-62.50O LOX) 30.46 B

ATOM 9641 OE1GLNB-584 -3^684 -22.172 -62J771 1.0030.92- B

ATOM- 9642 NE2 GLN B 584 ^~ -5,293-22.991-61,4281.002^21 B

ATOM 9643 C GLN-B: 584- -5.458--17-J22 -62τ948 hOO-^6.84 B

ATOM 9644 O GtN^B^" 584 -4.437-17739-9-62.497 1.0027.1=9- B

ATOM 9645 N ASN B 585 -6.251 -17.314 -63.833^~1.0023T66 B

ATOM 9646 CA ASN-B 585 -5.945-15.991-64.3591.0024.43 B

ATOM 9647 CB ASN B 585 -7.053-15.521-65.2971.0022.38 B

ATOM 9648 CG ASN B 585 -6.999-16.204-66.651 1.0020.41 B

ATOM 9649 ODl ASNB 585 -5.919-16.536-67.143 1.0017.91 B

ATOM 9650 ND2ASNB585 -8.160 -16.400 -67.267 LOO 19.21 B

ATOM 9651 C ASN B 585 -5.686-14.937-63.303 1.0025.42 B

ATOM 9652 O ASN B 585 -4.655-14.270-63.3401.0026.28 B ATOM 9653 N GLNB 586 -6.614-14.787-62.361 1.0026.48 B

ATOM 9654 CA GLN B 586 -6.467-13.797-61.2921.0026.83 B

ATOM 9655 CB GLN B 586 -7.742-13.750-60.433 1.0028.87 B

ATOM 9656 CG GLN B 586 -7.651 -14.368 -59.0341.0034.27 B

ATOM 9657 CD GLRB 586 -6.966-13.460-58.001 1.0037.68 B

ATOM 9658 OEl GLN B 586 -7.127-12.223-58.033 1.0038.^'87 B

ATOM 9659 NE2GLNB586 -6.217-14.073-57.0621.0037.34 B

ATOM 9660 C GLN B 586 -5.233-14.076-60.431 1.0025.40 B

ATOM 9661 O GLNB 586 -4.493^" -13.164 -60.0801.0023.71 B

ATOM 9662 N GLNB 587 -4.998 -15.338^~-60.0991.0025.46 B

ATOM 9663 CA GLN B 587 -3.841-15.681-59.2921.0026.28 B

ATOM 9664 CB GLN B 587 -3.83.8-17.174-58.9791.0026.54 B

ATOM 9665 CG GLNB 587 -4.947-17.560-58.0101.0026.70 B

ATOM 9666 CD GLNB-5S7 -4.916-19.024-57.5971.0026.53 B

ATOM 9667 OEl GLN B 587 -5.360-19.377-56.4961.0027.83 B

ATOM 9668 NE2GLNB587 .4.404 -19.885 -58.4791.0024.80 B

ATOM 9669 C GLNB 587 -2.561-15.281-60.003 1.0026.44 -B

ATOM 9670 O GLN B.587 -1.616-14.799-59.3761.0026.98 B

ATOM 9671 N ASNB 588 -2.534-15.473-61.3171.0026.11 B

ATOM 9672 CA ASN B 588 -1.365-15.105-62.1041.0Θ 25.50 B

ATOM 9673 CB ASNB 588 -1.303 -15.932 -63371 1.0026:23 B

ATOM 9674 GG ASNB"5£8 -0.952.-17.351-63,089 1.0028.58 B.

ATOM 9675 ODl ASN B 588 0.144-17.643-62.615 1.00-31.06 JB.

ATOM 9S26 ND2ASN;Br588 -1.883 -18.255 -63.355 W)O 30.69 ^"B

ATOM 9677 C^" ASN-B 5SS - 1.405 - 13.632 -62Λ561.90-24.58 B

ATOM 9678 O- ASN=B-588 -JO.448 -1-3.089 -63.09T): 1.0024.25- B

ATOM- 9679 N GLY-B-589 -2.515-12.981-62.143 1.0023.99 B

ATOM 9680 CA GLY B 589 -2.616 -11.567 -62Λ301.0024.70 B

ATOM 9681 C GLY B 589 -2.677-11.246-63.908 1.-0025.08 B

ATOM 9682 O GLYB 589 -2.027-10.302-64.3771.0023.78 B

ATOM 9683 N GLUB 590 -3.472-11.973-64.6181.0025.65 B

ATOM 9684 CA GLU B 590 -3.664-11.711-65.985 1.0025.69 B

ATOM 9685 CB GLUB 590 -4.021-12.974-66.6771.0025.01 B

ATOM 9686 CG GLU B 590 -3.020-13.293-67.735 1.0029.43 B ATOM 9687 CD GLU B 590 -1.993-14.198-67.2831.0031.16 B

ATOM 9688 OEl GLU B 590 -0.819-13.877-67.3881.0029.80 B

ATOM 9689 OE2 GLU B 590 -2.409 -15.224 -66.815 1.0033.16 B

ATOM 9690 C GLU B 590 -4.614-10.619-66.2561.0024.63 B ATOM 9691 O GLUB 590 -5.464-10.386-65.478 1.0025.03 B

ATOM 9692 N VAL B 591 -4.460 -9.936 -67.3701.0022.84 B

ATOM 9693 CA VAL B 591 -5.381 -8.866-67.7041.0020.75 B

ATOM 9694 CB VALB 591 -4.671 -7.674-68.4041.002L13 B

ATOM 9695 CGl VAL B 591 -5.689 -6.805-69.1401.0019.57 B ATOM 9696 CG2VALB-591 -3.929 -6.834-67.3851.0020.67 B

ATOM 9697 C VAL B 591- -6.349 -9.492-68.6981.0020.16 B

ATOM 9698 O VAL B 591 -5.929 -W.083 -69.6851.0018.31 B

ATOM 9699 N LEU B 592 -7.642 -9.397-68.428 1.0019.57 B

ATOM 9700 CA LEU B 592 -8.611 -9.947-69.3511.0018.93 B ATOM 9701 CB LEUB 592 -9.899-10.318-68.618 l.Oα 18.35 B

ATOM 9702 CG LEU B 592 -9.752-11.371-67.5141.00-18.27 B

ATOM 9703 CDl LEU B 592 -11.132 -11.S04 -67.029 1.0017.83 B

ATOM 9704 CD2 LEU B 592 -8.978-12.570-68.031 l.OΘ^'17.27 B

ATOM 9705 C LEU B 592 -8.879 -8.884-70.405 1.0019.04 B ATOM 9706 O XEU B 592 -9.216 -7.744-70,0791.00-18.66 B

ATOM 9707 N GLY B 593 -8.708 -9.261-71.671 1.0018.75 B

ATOM 97ff8-CA GLYB593 -.8.925 -8.329-72.7661.0017.22 B

ATOM -9709 C GLY B 593 -7.599 -7.900-73.345-1.0017.06 B

ATOM 97H)-O -GLY B 593 -6.572- -8.518 -73\075i ITOO T&47 B ATOM 9711 N TRP B 594 -7.622 -6.833 -74.1381.0G 16.87 B

ATOM 9712 GA TRPF-594- -6.418 -6.311 -74.7S71.00.18.04- B

-ATOM 9713 CB- TRP B 594 =6.291 -6.909 -76.200 LOO 18:tS- B

ATOM 9714 CG TRP B 594 -7.628- -7.129 -76.8621.0016.90 B

ATOM 9715 CD2 TRP B 594 -8.486 -8.263-76.6861.0015.42 B ATOM 9716 CE2 TRP B 594 -9.695 -7.983-77.3621.0014.47 B

ATOM 9717 CE3 TRP B 594 -8.352 -9.486-76.0161.0014.67 B

ATOM 9718 CDl TRPB 594 -8.328 -6.237-77.628 1.0016.37 B

ATOM 9719 NEl TRPB 594 -9.571 -6.742-77.9291.0014.27 B

ATOM 9720 CZ2TRPB594 -10.768 -8.883-77.3841.0014.61 B ATOM 9721 CZ3 TRP B 594 -9.415-10.378-76.0381.0014.12 B

ATOM 9722 CH2 TRP B 594 -10.608-10.072-76.7171.0014.26 B

ATOM 9723 C TRP B 594 -6.475 -4.786-74.8471.0018.19 B

ATOM 9724 O TRP B 594^' -6.932 -4.205-75.843 1.0019.18 B

ATOM 9725 N PRO B 595 -6.029 -4.120-73.7571.0018.25 B

ATOM- 9726 CD PROB395_ -5.561 -4.802-72.5361.0018.33 B

ATOM 9727 CA PRO B 595 -5.981 -2.664-73.5721.0017.09 B

ATOM 9728 CB PRO B 595 -5.440 -2.512-72.155 1.0016.64 B

ATOM 9729 GG PKO B 595 -5.816 -3.774-71.4931.0017.15 B

ATOM 9730 C PRO B 595 -57061 -2.014- -74.593 1.0018.28 B

ATOM 9731 O PRO-B-595 -5.303 -0.904- -75.041 1:0018=74 B

ATOM 9732 N GLU B 596 -3.984 -2.703 -74τ941 1.0019.79 B

ATOM 9733 CA GLU B 596 -3.056 -2.179-75.9291.0022.51 B

ATOM 9734 CB GLU B 596 -1.659 -£721-75.6391.0022.28 B

ATOM 9735 CG GLU B 596 -1.248 -2.525 -74.193 l.OΘ 24.21 B

ATOM 9736 CD GLU-B 596 0.267 -2.485 -73.999 l.QO 27.43 B

ATOM 9737 OEl GLU B 596 1.023 -2.894-74.9221.0028.50 B

ATOM 9738 OE2GLUB596 0.704 -2.053-72.9081.0028.14 B

ATOM 9739 C GLU B 596 -3.564 -2.611-77.321 1.0023.38 B

ATOM 9740 O GLU B 596 -2.839 -3.214 -7S.121 1.0023.92 B

ATOM 9-741 N TYR B- 597 -4.832 -2.287 -7J7.581 1.0023.34 B

ATOM 9742 CA TYRB 597 -5.530 -2.636 -78.8T61.0022.8L B-

ATΘM- 9743 CB TYRB 59J -6.9-19 -1.977-78.833 1.ΘQ 19.88 B

ATOM- 9744 CG TYR B 597 -6.883 -0.469-78.846 1.0017.48^" B

ATOM 9745 GDI T¥R:B-59-7 -6.234 O7224 -79.8641.0017.68 B

ATOM 9746 CE1TYRB-59T -6.177 1.6-1-7-79:8801-0017.68 Br

ATOM 9747 CD2 TYRΕ-597 -7.481 0.271-77.8341.0018.31 B

ATOM 9748 CE2 TYRB 597 -7.432 1.673 -77.8371.0017.76 B

ATOM 9749 CZ TYR B 597 -6.780 2.337-78.8671.0017.85 B

ATOM 9750 OH TYR B 597 -6.759 3.712-78.915 1. OQ 17.22 B

ATOM 9751 C TYR B 597 -4.778 -2.261-80.089 1.0023.71 B

ATOM 9752 O TYRB 597 -5.179 -2.645-81.193 1.0023.86 B

ATOM 9753 N GLN B 598 -3.690 -1.519-79.936 1.0023.63 B

ATOM 9754 CA GLN B 598 -2.910 -1.079-81.076 1.0023.07 B ATOM 9755 CB GLN B 598 -2.373 0.322 -80.796 1.0023.68 B

ATOM 9756 CG GLN B 598 -2.858 1.385 -81.749 1.0024.23 B

ATOM 9757 CD GLN B 598 -2.345 2.767 -81.400 1.0025.47 B

ATOM 9758 OEl GLN B 598 -1.172 3.064 -81.579 1.00 24.79 B

ATOM 9759 ^"RE2 GLN B 598 -3.227 3.618 -80.891 1.00 24.38 B

ATOM 9760 C GLN-B 598 -1.747 -1.989 -81:451 1,0.023.72 B

ATOM 9761 O GLN B 598 -1.359 -2.039 -82.606 1.0025.21 B

ATOM 9762 N TRPB 599 -1.202 -2.710 -80.476 1.0024.26 B

ATOM 9763 CA TRP B 599 -0v044 -3.588^~-8ϋ.670 L-GO 24.40 B

ATOM 9764 CB TRPB 599 0.274 -4.304 -79.359 1.0022.35 B

ATOM 9765 CG TRPB 599 1.486 -5.152 -794-40 1.0020.33 B

ATOM 9766 CD2 TRP B-599- 1.525 -6.563 -79.654 1.00J9.86 B

ATOM 9767 CE2 TRP B 599 2.887 -6.933 -79.752 1.00 19.72 B

ATOM 9768 CE3 TRP B 599 0.543 -7.551 -79.778 1.00 18.62 B

ATOM 9769 CDl TRP B 599 2.781- -4.733 -79.409 1.00 -19.35 B

ATOM 9770 NEl TRP B 599 3.632 -5.796 -79.596 1.00 19.14 B

ATOM 9771 CZ2 TRP B 599 3.290 -8.248 -79.967 1.00 19.46 B

ATOM 9772 CZ3 TRP B 599 0.945 -8.858 -79.993 1.0020.74 B

ATOM 9773 CH2TRP B 599 2.308 -9.196 -80.086 1.0020.13 B

ATOM 9774 C TRP B 599 -0.081 -4.631 -81.795 1.0026J9 B

ATOM 9775 O TRP B 599 -1.104 -1.272 -82.G27 1.002S.39 B

ATQM 9776 N HIS B 600 L0S4- -4,802 -82.^"464 1.0025.71 B

ATOM- 9777 CA HTS B 600 1.253 -5.759 -83.557 1.00.24.44 B

-ATOM ^"9778 CB fflS_B.6θθ L224 -5.056 -84.908 1.0026.64 ~fr

ATOM 9779- CG HIS B 600 -0446- -4.687 -85.383- 1.00 28.02 B

ATOM 9780 CD2 HIS B-600 -0.792 -4.972 -86.533- 1.00-29.43 B

ATOM 97sr NDl HIS B 600 -1.019 -1.929-84.63T LOO 28.33 B

ATOM 9782 CEl HIS B 600 -2.14-7 -3.772 -85.3.00 1.00:28.59 B

ATOM 9783 NE2JHIS-B 6Θ0 -2.039 -4J93 -86.457 1.00 30.36 B

ATOM 9784 C HIS B 600 2.624 -6.389 -83.377 1.0023.78 B

ATOM 9785 O HIS B 600 3.571 -5.715 -83.003 1.0022.74 B

ATOM 9786 N PRO B 601 2.763 -7.691 -83.652 1.00 24.01 B

ATOM 9787 CD PRO B 601 1.863 -8.794 -84.035 1.00 22.66 B

ATOM 9788 CA PRO B 601 4.124 -8.177 -83.437 1.0024.27 B ATOM 9789 CB PRO B 601 3.938 -9.688-83.3871.0022.37 B

ATOM 9790 CG PRO B 601 2.829 -9.901-84.3551.0020.29 B

ATOM 9791 C PROB 601 5.031 -7.730-84.5661.0025.00 B

ATOM 9792 O PRO B 601 4.560 -7.406-85.653 1.00Z5.56 B

ATOM 9793 N PROB-602 6.346 -7.678-84.313 1.00-26-.23 B

ATOM 9794 CD PRO 3602 7.038 -7:977-83.0501.0026.69 B

ATOM 9795 CA PRO B 602 7.309 -7.274-85.331 1.0028.08 B

ATOM 9796 CB PRO B 602 8.544 -6.965-84.5071.0026.37 B

ATOM 9797^" CG PRO B 602 8.489 -8.028-83.481 1.0025.22 B-

ATOM 9798 C PRO B 602 7.513 -8.481-86.2571.0029.84 B

ATOM 9799 O PRΘB 602 7.060 -9.592-85.951 1.0029.70 B^~

ATOM 9800 N EEU B- 603 8.191 -8.256-87.378 l.OQ 30.96 B

ATOM 9801 CA LEU B 603 8.566 -9.340-88.2771.0032.53 B

ATOM 9802 CB LEU B 603 8.962 -8.786-89.6471.0032.60 B

ATOM 9803 ^"CG LEU B 603 7.841 -8.152-90.473 1.0032.92 B

ATOM 9804 CDl LEU B 603 8.289 -7.930-91.909 1.0031.38 B

ATOM 9805 CD2 LEU B 603 6.587 -9-011-90.4241.0033.31 B

ATOM 9806 C LEU B 603 9.707-10.169-87.6971.0034.94 B

ATOM 9807 O LEU B 603 10.660 -9.626-87.140 1.0034.98 B

ATOM 9808 N PRO B 604 9.602-11.487-87.833 1.0037.94 B

ATOM 9809 CD PRO B 604 8.430 -12.144 -88.4371.003.7.75 _B

ATOM 9810 CA PRO B 604 10.781-12.359-87.823 1.0040.78 B

ATOMr 981-1- CB PROB 604 10.312_rl3v584-88.613 1.00-39.05 B

-ATOM 9812 CG- ERO B-6Θ4 87834-13.587 -88.459 1.0038:81 B

ATOM- 981-3 C PRO B 604 -14.976 -11.776 -88-571 1:00-45.17 B

ATOM 9814 Θ-- ESOB 604 1-1.800-11.1-28-897603 l.OQ 47.41 B

ATOM ^T9815 N ASP-B 605 137176--12.012 -88.0521.0Q-48.56 BL

ATOM ^"9816 CA ASP B 605 14.250 -11.028 -88.1201.0052.15 B

ATOM 9817 CB ASP B 605 15.521-11.577-87.469 1.0053.76 B

ATOM 9818 CG ASP B 605 15.680-11.127-86.030 1.0055.75 B

ATOM 9819 ODl ASP B 605 15.880 -9.915 -85.8041.0056.60 B

ATOM 9820 OD2ASPB605 15.620-11.913-85.061 1.0055.90 B

ATOM 9821 C ASP B 605 14.535-10.622-89.5621.0054.28 B

ATOM 9822 O ASP B 605 14.423 -9.450-89.921 1.0055.90 B ATOM 9823 N ASNB 606 14.802-11.655-90.3501.0055.38 B

ATOM 9824 CA ASN B 606 14.935-11.636-91.801 1.0057.31 B

ATOM 9825 CB ASN B 606 16.114-12.503-92.108 1.0059.58 B

ATOM 9826 CG ASNB 606 17.330-11.738-92.454 LOO 62.57 B ATOM 9827 ODl ASN-B 606 17.340-10.505-92.4541.0063.43 B

ATOM 9828 ND2 ASN B 606 18.384-12.464-92.7881.0062.93 B^:

ATOM 9829 C ASN B 606 13.793-12.406-92.4181.0057.54 B

ATOM 9830 O ASN B 606 13.657-13.547-92.115 1.0059.03 B

ATOM 9831 N TYRB 607 12.987-11.843-93.301 1.0056.40 B ATOM 9832 CA TYRB 607 11.743-12.517-93.652 1.0055.47 B

ATOM 9833 CB TYR B 607 10-591-11.997-92.7901.0050.00 B

ATOM 9834 CG TYRB 607 9.255-12.633-93.1041.0044.88 B

ATOM 9835 CDl TYRB 607 8.169-11.859-93.4871.0042.99 B

ATOM 9836 CEl TYRB 607 6.946-12.436-93.7761.0041.72 B ATOM 9837 CD2 TYRB 607 9.082-14:008-93.0181.0042.40 B

ATOM 9838 CE2TYRB607 7.863 -14.594. -93.304 l.OQ 40.13 B

ATOM 9839 CZ TYRB 607 6.799-13.804-93.683 1.0041.06 B

ATOM 9840 OH TYRB 607 5.584 -L4.3S1 -93.9691.0040.79 B

ATOM 9841 C TYRB 607 11.415-12.335-95.1301.0057.83 B ATOM 98420 TYR B 607 10.882-11.302-95.5351.0058.43 B

ATOM 9843 N- PRO B 608- 11.737-13.345-95.931 1.0060.05 B

ATΘM 9844 CD PRO B 60S 10.984 -D.247 -97.194- 1.0.0^~60.21 B

ATOM 9-845 CA PRO B 60S I L812 -14.725 -95440 l.Q0_62.31 B

ATΘM 9846- CB PRO B' 608 i-1,294 -15.543--96.625^~ 1,0061762 B ATOM 9847 CG PRO BJ5.08 10r38-l -14:615-97.3441.00-61.39 B

ATOM 9848 C PRO B 608- 13.244-15.1^1-9-5:1091.0065.10 B

ATOM 9849 O PROB 608 13.697--14.93O-9379821.0065:94- B-

ATOM 9850 N ALA B 609 13.944-15.698-96.0861.0067.44 B

ATOM 9851 CA ALA B 609 15.030-16.630-95.809 1.0068.86 B ATOM 9852 CB ALA B 609 16,348-15.884-95.671 1,0067.85 B

ATOM 9853 C ALA B 609 14.747-17.450-94.5541.0070.14 B

ATOM 98540 ALA B 609 15.575-17.519-93.6471.0069.73 B

ATOM 9855 N GLYB 610 13.572-18.069-94.511 1.0071.84 B

ATOM 9856 CA GLYB 610 13.236-18.994-93.4441.0073.77 B ATOM 9857 C GLY B ( 510 13.423-20.442-93.852 1.0076.01 B

ATOM 9858 O GLYBl 510 14.192-20.746-94.7641.0076.47 B

ATOM 9859 N ALAB ( 511 12.715-21.339-93.173 1.0077.24 B

ATOM 9860 CA . ALAB 611 12.774-22.761-93.4901.0078.25 B

ATOM 9861 CB ALAB 611 13.241 -23.554 -92.2791.0077.63 B

ATOM 9862 C ALAB< 511 11.423-23,274-93.9771.0078.95 B

ATOM 9863 O ALAB ( 511 10.528-23.549-93.1781.0079.15 B

ATOM 9864 N ALAB < 512 11.284-23.401-95.293 1.0079.32 B

ATOM 9865 CA . ALAB 612 10.615-24.534-95.8851.0079.35 B

ATOM 9866 CB ALAB 61Z 9.347 -24.121 -96.6041.0079.68 B

ATOM 9867 C ALA B- 612 11.542-25.299-96.840 1.007935 B

ATOM 9868 O ALABf 512 12.216-26.251-96.449 1.0079.79 B

ATOM 9869 Cl NAGB 691 0.277 -2.189-99.215 1.0043.17 B

ATOM 9-870 C2 NAGB 691 1.315 -1.293-99.8651.0043.92 B

ATOM 9871 C3 NAGB 691 2.320 -2.149-100.638 1.0044.81 B

ATOM 9872 C4 NAGB 691 2.858 -3317-99.8041.0044.49 B

ATOM 9873 C5 NAGB 691 1.707 -4.076-99.141 1.00443.4 B

ATOM 9874 C6 NAGB 691 2.128 -5.187-98.1871.0043.75 B

ATOM 9875 C7 NAGB 691 -0.649 -0.416-100.9961.0043.93 B

ATOM 9876 C8 NAGB 691 -1.102 -1.212-102.2121.0043.04 B-

ATOM 9877 N2 NAGB 691 0.665 -03-46^"-100.76I 1.0044.47 B

ATOM 9878 O3 NAGB 691 3.410- -1.342-101.049 1.0046.85 B-

ATOM 9879 O4 NAG-B 691 3-571

B

ATOM- -S88Θ- G5 NAGB 691 0.907 -3.160 -98.m hOO 44.10 B

ATOM- 9SSl OJ6 NAGB 691 3^528 -5:432 --98-.232_1.0045.28 B-

ATOMr 9882 O7 NAG-B 691 -1.488 0.132-J00.281 1,0043.31 B

ATOM- 9883 Cl -NAG B 692 -14.686-35.112-114.5291.0071:3* B

ATOM 9884 C2 NAGB 69-2 -15.379-36.430-114.880 1.0071:24 B

ATOM 9885 C3 NAGB 692 -14.720-37.003-116.1421.0071.03 B

ATOM 9886 C4 NAGB 692 -14.864-35.962-117.2821.0071,19 B

ATOM 9887 C5 NAGB 692 -14311-34.585-116.8591.0071.66 B

ATOM 9888 C6 NAGB 692 -14.637-33.506-117.895 1.0071.44 B

ATOM 9889 C7 NAGB 692 -14.418-38.231-113.5241.0069.41 B

ATOM 9890 C8 NAGB 692 -14.814-39.696-113.4991.0068.03 B ATOM 9891 N2 NAG B 692 -15.394 -37.354-113.750 1.00 70.28 B

ATOM 9892 03 NAG B 692 -15.370 -38.213-116.499 1.00 70.82 B

ATOM 9893 04 NAG B 692 -14.182 -36.403-118.452 1.00 70.91 B

ATOM 9894 05 NAG B 692 -14.897 -34.163-115.597 1.00 72.13 B

ATOM 9895 06 NAGB 692 -14,203 -32.211-117.485 1.00 70.58 B

ATOM 9896 07 HAG B 692 -13.248 -37.904-113.314 1.00 68.66 B

ATOM 9897 Cl NAG B 693 -43.251 -33.964-104.086 1.00 62.90 B

ATOM 9898 C2 NAG B 693 -44.231 -35.025-103.599 1.00 62.20 B

ATOM 9899 C3 NAG B 693 -43.661 -36.424-1O3.799 1.00 62.28 B

ATOM 9900 C4 NAG B 693 -43.137 -36.601-105.219 1.00 62.92 B

ATOM 9901 C5 NAG B 693 -42.226 -35.445-105.614 1.00 64.10 B

ATOM 9902 C6 NAG B 693 -41.767 -35.582-107.061 1.00 65.18 B

ATOM 9903 C7 NAG B 693 -45.045 -33.889-101.618 1.00 61.18 B

ATOM 9904 C8 NAGB 693 -45.039 -33.806-100.301 1.00 60.99 B

ATOM 9905 N2 NAGB 693 -44.295 -34,846-102.156 1.0061.23 B

ATOM 9906 O3 NAG B 693 -44.682 -37.396-103.542 1.0062.92 B

ATOM 9907 O4 NAG B 693 -42.413 -37.833-105.310 1.00 63.17 B

ATOM 9908 05 NAG B 693 -42.923 -34.212-105.452 1.00 64.49 B

ATOM 9909 O6 NAG B 693 -42.910 -35.694-107.915 1.00 63703 B

ATOM 9910 O7 NAG B 693 -45.713 -33.115-102.284 1.00 62.26 B

ATOM 9911 Cl NAG B 694 -43.235 -39.087-105.800 1.00 77.18 B

ATOM 9942 C2 NAG B 694 -42.507 -40.246-106.468 1^)0-76.27 B

ATOM 9913 C3 NAG B 694 -43.211 -41.568-106rl88 1.00 7635 B-

ATOM 9914 C4- NAG.B 694 -43L5QD -41.728-104.700 1.00 76.77 B

ATOM 9915 C5 NAG B 694 -44.169 -40,480-104.137 1.90 77.59 B

ATOM- 9916 C6 NAGB- 694 -44.390 -40,609-102.635 1.00 7K00 B

ATOM 9917 C7 NAG B 694 -41.659 -39.626-108.655 1.00 75.55 B

ATOM 9918 C8 NAG B 694 -41.913 -39.452-109.938 1.00 76.48 B

ATOM 9919 N2 NAG B 694 -42.677 -4JO.024-107.896 1.00 75.41 B

ATOM 9920 03 NAG B 694 -42.386 -42.652-106.632 1.00 75.49 B

ATOM 9921 O4 NAG B 694 -44.355 -42.859-104.499 1.00 76.58 B

ATOM 9922 O5 NAG B 694 -43.352 -39.342-104.402 1.00 78.17 B

ATOM 9923 O6 NAGB 694 -44.639 -39.314-102.076 1.00 80.36 B

ATOM 9924 O7 NAG B 694 -40.540 -39.425-108.212 1.00 75.83 B ATOM 9925 Cl NAG B 695 -15.056 -15.625-114.327 1.00102.82 B

ATOM 9926 C2 NAG B 695 -13.822 -16.427-114.722 1.00102.28 B

ATOM 9927 C3 NAG B 695 -13.157 -15.833-115.958 1.00102.34 B

ATOM 9928 C4 NAG B 695 -14.177 -15,589-117.062 J.00102.83 B ATOM 9929 C5 NAG B 695 -15.391 -14.838-116.529 1.00103.38 B

-ATOM 9930. C6 NAG B 695 -16.445 -14.660-117.616 1.00104.50 B

ATOM 9931 C7 NAG B 695 -12.581 -14.982-113.221 1.00100.46 B

ATOM 9932 C8 NAG B 695 -13.197 -13.989-113.832 1.00100.44 B

ATOM 9933 N2 NAG B 695 -12.8-71 -16.210-113.641 1.00101.46 B ATOM^" 9934 03 NAG B 695 -12.145 -16.728-116.432 1.00101.84 B

ATOM 9935^~ 04 NAG B 695 -13.570 -14.828-11-8.114 1.00103.62 B

ATOM 9936 05 NAG B 695 -15.953 -15.560-115.434 1.00103.12 B

ATOM 9937 06 NAG B 695 -17.063 -15.923-117.892 1.00106.19 B

ATOM 9938 07 NAG B 695 -11.791 -14.759-112318 1.0099.7-1 B ATOM 9939 Cl NAG B 696 4.809 -3.410-101.426 1.0099.23 B

ATOM 9940 C2 NAG B 696 6.193 -2.782-101.313 1.0098.89 B

ATOM 9941 C3 NAG B 696 7,191 -3.489-102.222 1.0099.24 B

ATOM 9942 C4 NAG B 696 7.123 -5.000-102.037 1.00 99.51 B

ATOM 9943 C5 NAG B 696 5,683 -5.495-102.108 1.0099.13 B ATOM 9944 C6 NAG B 696 5.608 -6.995-101.848 1.00 98.84 B

ATOM- 9945 C7 NAG B 696 6.71S -2.132 -99.037 LOO 95791 B

ATOM 9546 C8 NAG B 696 7.129- -230JS--9-7.839 1.00 95.12 B

ATOM 994J N2- NAGB 696 6.634 -3.085 -99.960 1.00 97.48: B

ATOM 9948- 03 NAGtB-696. 8.514 -3.03-1-10L-925 1.00 99.11 B^~ ATOM 9949 04 NAG B 696 7.899 -5.641-103.055 1.0099.81 B

ATOM -9950 Q5 NAGB 696 4.895 -4.804-101.141 1.00 99:61 B.

ATOM 9951 06 NAG B 696- 4.306 -7.476-102.203 1.00 97τ80 B

ATOM 9952 07 NAG B 696 6.436 -0-966 -99.258 1.00 95.04 B

ATOM 9953 Cl BMA B 901 -45.729 -43.920-104.673 1.00 87.0P -B ATOM 9954 C2 BMA B 901 -46.689 -44.687-103.759 1.00 87.10 B

ATOM 9955 02 BMA B 901 -47.773 -45.203-104.532 1.00 87.95 B

ATOM 9956 C3 BMA B 901 -45.934 -45.842-103.095 1.00 86.35 B

ATOM 9957 03 BMA B 901 -46.848 -46.652-102.357 1.00 85.45 B

ATOM 9958 C4 BMA B 901 -45.265 -46.681-104.188 1.00 85.90 B ATOM 995904 BMAB 901 -44.434-47.676-103.586 1.0085.36 B

ATOM 9960 C5 BMA B 901 -44.411-45.763-105.0671.0085.68 B

ATOM 9961 C6 BMA B 901 -43.709-46.598-106.140 1.0084.30 B

ATOM 996206 BMAB 901 -42.907-45.745-106.9601.0.083 Λ9 B ATOM 9-96-3-Θ5-BMAB901 -45.238 -44.787-105.fi92 1.0086.29 B

ATOM 9964 OH2 WAT^"C^" 1 -42.555 -15.868 -26.385- 1.0046.71 C

ATOM 9965 OH2WATC 2 -27.074-20.507-34.508 1.003.79 C

ATOM 9966 OH2WATC 3 -31.258-23.723-63.604 1.0026.06 C

ATOM 9967OH2WATC 4 -20.927 -1:643-67.691 1.0035.66 C ATOM 9968 OH2 WAT C 5 -12.296 -8.0-ΪD -56.0591.0016.23 C

ATOM 9969-OH2WATC 6 -20:821=26.90-7-93.641 1.0010.66 C

ATOM 99-70 OH2 WAT C 7 5.209-10:962-87.1261.0013.46 C

ATOM 9971 OH2WATC 8 -28.559 -4.019-89.0961.0030.54 C

ATOM 9972 OH2 WAT C 9 -28.159 -4.597 -82.0391.0026.21 C ATOM 9973 OBSWATC 10 9.084-22.778-80.3361.0023.78= C

ATOM 9974 OH2WATC 11 -0327-10.826-77.5301.0010.11 C

ATOM 9975 OH2 WAT-C 12 -2.412-29.863-59,094 1.0025.71 C

ATOM 9976 OH2WATC 13 -21.078-35,073-72.9141.0.026.35 C

ATOM 9977 OH2 WAT C 14 -24.153-61.605-21.7661.0029.95 C ATOM 9978 OH2 WAT C 15 -15.729 -5.831 -39.546 kOΘ 4.82 C

ATOM 9979- OB2 WAT C 16 ΘΛ09 -22.486 -42.7701.0ft 36.51 C

ATOM 9980 OHZWAT-C 17 -31.07-9 -11.649 -34.159 LOO 12.10 C

ATOM 99El ©H2-WATC 18- -3.943 --2JM)W -48.5261.0035.31 C

ATOM 99-82 OH2~WAT C 19 -21.340 -26.494-121.713-1,0020.58 C ATOM 9983^~ΘH2 WAT C 2G -20306-14.241 -98.674 LOO 26.68 C

-ATOM -9984 OH2 WAT C 21 -15τ334 -6.033 =98.213-1.0052.85 C

ATOM 99850H2 WATJC 22 -2.098-20.525-60.189 1.0027.00 C

ATOM 9986 OH2 WAT C 23 -25.274 -4:028-82.7661.0023.14 C

ATOM 9987 OH2 WAT C 24 -27.63.0-26.845-32.171 1.0022.67 C ATOM 9988^" OH2 WAT C 25 -27.653-27.486-95.8561.0013.72 C END TABLE B

REMARK coordinates from restrained individual B-factor refinement

REMARK refinement resolution: 500.0 - 2.8 A

REMARK starting r= 0.2978

0.3142 REMARK final

0.3144

REMARK B rmsd for bonded mainchain atoras= L 117 targets 1.5

REMARK B rmsd for bonded sidechain atoms= 1.364 targets 2.0

REMARK B rmsd for angle mainchain atoms= 1.929 target 2.0

REMARK B rmsd for angle sidechain atoms= 2:209 target= 2^".5^"~ REMARK rweight^ OJOOO (with wa= 3.71302)

REMARK target= mlf steps= 30

REMARK sg= C222(l) a= lQ1.32b= 21-θ_;9_c= 171.03 alpha== 90 beta= 90 gamma= 90

REMARK parameter file 1 : CNS TOPPARφrotein rep.param REMARK parameterfile 2 : CNS_TOPPAR:ion.param

REMARK parameter file 3 : ../lis.par

REMARK parameter file 4 : ../both.par

REMARK parameter file 5 : CNS_TOPPAR:waterjrep.param

REMARK molecular structure file: gen.mtf REMARK input coordinates: rig.pdb

REMARK reflection-.file= ../nlis_c2221_2Xcv

REMARK ncs= none

REMARK B-correction_tesolutien÷ 6.Q - 2.8^"

REMARK B^factor correction applied,to=coordinate array B: -0.038 - REMARK bulk seiventrriensity level= 0.3553-77 e/A^3, B-factor= 40:7967 A^Λ2

<-Q,0 rejected ^"REMARK reflections wMr|Fobs| > 10000 * rms(Fobs)_rejected

REMARK theoreticai total number of refl. in resol. range: 45416.( 100.0 % )

REMARK number of unobserved-reflections (no entry or |F|=0): 516S.(. 11.4 % ) REMARK number of reflections rejected: 0 ( 0.0 % )

REMARK total number of reflections used: 40248 ( 88.6 % )

REMARK number of reflections in working set:. 39216 ( 86.3 % )

REMARK number of reflections in test set: 1032 ( 2.3 % )

CRYSTl 101.320 210.900 171.030 90.00 90.00 90.00 C 2221 REMARK FILENAME="bind.pdb"

REMARK DATE: 12-Sep-2005 10:12:45 created by user: hazel

REMARK VERSION: 1.1

ATOM 1 CB ALAA 1 -24,710-36.906 -9.3721.0067.69 A

ATOM 2 C ALAA 1 -25.445-37.404 -7.068 LOO 67.77 A

ATOM 3 O ALAA 1 -25.053-37.915 -6.022 l.OΘ 68.42 A ATOM 4 N ALAA 1 -23.174-36.806 -7.433 1.0067.30 A ATOM 5 CA ALAA 1 -24.547-36.527 -7.8971.0067.68 A ATOM 6 N ASPA T -26.643 -37.602 -7.5921.0067.92 A AATTOOMM 7 CA ASP A 2 -27.598-38.514 -7.011 1.0068.00 A ATOM 8 CB ASPA 2 -28.S80 -38.508 -7:8621.00-67.74 A ATOM 9 CGASPA- 2 -30.046-39.203 -7.198 LQO 67.76 A- ATOM 10 ODl ASP A 2 -30.172-39.079 -5.9601.0068.05 A ATOM 11 OD2ASPA 2 -30.851 -39.839 -7.9191.Θ067.03 A ^" ATOM 12 C ASPA 2 -26.770-39.728 -7.3971.0068.13 A ATOM 13 O ASPA 2 -25.839-39.614 -8.178 LJOO 69.02 A ATOM 14 N PROA 3 -27.060-40.889 -6.8251.0067.93 A ATOM 15 CD PROA 3 -27.503 -40.894 -5.4261.0067.99 A ATOM 16 CA PROA 3 -26.341-42.128 -7.151 1.0067.92 A

AATTOOMM 1 177 CCBB PPRROOAA 33- -26.221-42.838 -5.8001.0068.08 A A A A'TTlVUOYMMIV Λ 1 1 Io8 Q C LυG _ Pr KROUA A J 3 -27.388-42.322 -5.0401.0068.34 A

AATTOOMM 19 C PROA 3^" -27.224 -42.869 -8.1761.0067.87 A

ATOM 20 O PRO A 3 -26.754-43.704 -8.961 1.0067,92 A

ATOM 2ϊ N GLYA 4 ,28:502 -42A85 -8T841.0067.18 -A. -- ATOM .22 CA GLYA -4 -29.461-43.042 -9.12Θ 1.0066.09 A

ATOM ^"23 C GLYA 4 -.29-7229 -42.298-10-4241:0065.02 A

ATOM -24 O GLYA 4 -3QΛ39 -42.097 -11.2=1=61.006^"4.75 A

ATOM- 25 N LEUA 5 -27.994-41.835-10,607 LOG 63.70 A

ATOM 26 CA-LEUA 5 -27.582-41.132-11.829 LOO 6J.45 A A ATTOOMM 2277 CCBB LLEEUUAA 55 -27.487-39.600-11.6581.0061.02 A

Α A ATT Ira UOJMVjl Z 2o8 C C l_Λ^GCjl L T JuE TϋHUTUTA Λ A 5 C

J -28.829-38.848-11.5671.0061.08 A

ATOM 29 CDlLEUA 5 -28.567-37.362-11.433 1.0060.76 A

ATOM 30 CD2LEUA 5 -29.707-39.132-12.791 1.0061.12 A

ATOM 31 C LEUA i -26.226-41.694-12.179 1.0060.16 A ATOM 32 O LEUA 5 -25.780-41.593-13.299 1.0059.74 A

ATOM 33 N GLNA 6 -25.583-42.322-11.190 1.0059.33 A

ATOM 34 CA GLNA 6 -24.259-42.937-11.405 1.0059.05 A

ATOM 35 CB GLNA 6 -23.579-43.227-10.073 1.0060,10 A ATOM 36 CG GLNA 6 -22.315-44.101-10.151 1.0061.12 A

ATOM 37 CD GLNA 6 -21.100-43.518 -9.473 1.0062.41 A

ATOM 38 OElGLNA 6 -20.073-44.184 -9.360 1.0062.75 A

ATOM 39 NE2GLNA 6 -21.204-42.275 -9.020 1.0063.05 A

ATOM" 40 C GLNA 6 -24.424-44.192 -123101.0057.76 A ATOM 41 O GLNA 6 -25.495-44.805-12.336 1.0057.57 A

ATOM 42 N PRO A 7 -23.349 -44.629 -12.996 LOO 56.55- A

ATOM 43 CD PROA 7 -21.948 -44.35S -12.618 1.0056.96 A

ATOM 44 CA PROA 7 -23.400-45.783-13.903 1.0055.78 A

ATOM 45 CB PROA 7 -2L950 -46.192 -14.015 1.0055.94 A ATOM 46 CG PROA 7 -21.198 -44.988 -13.725 f.0056.95 A

ATOM 47 C PROA 7 -24.248-47.024-13.5751.0055.04 A

ATOM 48 O PROA 7 -25.399-47.175-13.988 1.0055.06 A

ATOM 49 N GLYA 8 -23.522-47.980-13.0041.0053.71 A

ATOM 50 CA GLYA 8 -24.008 -49.285 -12.593 1.005 L44 A ATOM 51 C GLYA 8 -22.810-50.097-12.9881.0050.04 A

ATOM 52 O GLYA ^"8- -21.732-49.560-13.1771.0049779 A

ATOM 53 N ASNA 9 -23.021 --51.392-13.099 LOO 48.96 A

ATOM 54 CA ASNA 9 -21.994 -52.233 -13.680- 1.004&O0 A

ATOM 55 CB-ASNA 9 --21.157-53.187-12.8161.00_48.74 -A- ATOM 56 CG ASNA- 9 -19:948_=53.770 -13.652 1.00-49.58 A

ATOM 57 ODl ASN A 9 -20.080-53.896-14.8641.00-48:62 A^"

ATOM 58 ND2ASNA 9 -18.79-4 -54.046--T37032 LTX) 50.50 A

ATOM 59 C ASNA 9 -22.830-53.005-14.656 1.0046.74 A

ATOM 600 ASNA 9 -24.040-53.176-14.5441.0046.15 A ATOM 61 N PHEA 10 -22.065-53.344-15.6571.0044.11 A

ATOM 62 CA PHEA 10 -22.490-53.930-16.868 1.0040.45 A

ATOM 63 CB PHEA 10 -22.559-52.749-17.7761.0033.19 A

ATOM 64 CG PHEA 10 -23.765-51.935-17.575 1.0026.81 A

ATOM 65 CDlPHEA 10 -23.738-50.582-17.1861.0025.23 A ATOM 66 CD2PHEA 10 -24.967-52.529-17.8771.0024.20 A

ATOM 67 CElPHEA 10 -24.951-49.829-17.1321.0023.35 A

ATOM 68 CE2PHEA 10 -26.159-51.831-17.835 1.0022.99 A

ATOM 69 CZ PHEA 10 -26.176-50.476-17.4701.0020.95 A

ATOM 70 C PHEA 10 -21.475 -54.913 -17.4171.0042.07 A

ATOM 71 O PHE A.10 -20.340-54.941-16.981 1.0041.83 A

ATOM 72 N SERA 11 -21.852-55.611-18.4771.0044.07 A

ATOM 73 CA SERA 11 -20.988-56.628-19.093 1.0046.09 A

ATOM 74 CB SERA 11 -21:927 -57.671 -19.6771.0046.00 A

ATOM 75 OG SERA 11 -23.241-57.432-19.1961.0043.56 A

ATOM 76 C SERA 11 -19.878-56.229-20.1301.0047.52 A

ATOM- 77 O SERA Tl -20,009 -55.275 -20.8941.0047.11 A

ATOM 78 N ALAA 12 -18.780-56.986-20.153 1.0049.18 A

ATOM- 79 CA ALA.A 12 -17.648-56.714-21.058.1.0051.23 A

ATOM 80 CB ALA-A 12 -16.436 -57.524 -2Q.6371.0050.30 A

ATOM 8-1 C ALAA 12 -18.079 -57.146 -22.438.1.0052.98 A

ATOM 82 O ALAA 12 -17.287-57.221-23.391 1.Q052.53 A

ATOM 83 N ASPA 13 -19.370-57.439-22.561 1.0054.90 A

ATOM 84 CA ASP A 13 -19.904-58.058-23.769 1.0055.91 A

ATOM 85 CB ASPA 13 -20.764-59.272-23.413 1.0055.61 A

ATOM 86 CG ASP A 13 -19.935-60.483-23.034 1.0056.24 A

ATOM -87 ODl ASPA 13 -L8.736 -60:513-23.383 L00^:56.39 A

ATOM 88 OD2ASPA 13 -20.395-61.447-22.3871.0.055,80 A

-ATOM 89 C -ASPJA: 13^" -20.718-57.061-24.5881.0056.67 A

ATOM 90 O ASP A.13 -21.233 -56.079 =24.054-1.0056r74 _A

ATOM -91 N GtUA 14. -20.828 -57.321 -25:8871.00-5-7.39 A

ATOM 92 CA GLUA 14 -21.577 -56.447 -26.7821.0057.62 A

ATOM 93 CB GLUA 14 -21.494.-56.956-28.2221.0056.85 A

ATOM 94 CG GLUA 14 -20.405-56.296-29.053 1.00-55.60 A

ATOM 95 CD GLUA 14 -20.654-56.420-30.543 1.0054.28 A

ATOM 96 OEl GLUA 14 -21.637-55.828-31.035 1.0051.94 A

ATOM 97 OE2GLUA 14 -19.865-57.110-31.223 1.0053.73 A

ATOM 98 C GLUA 14 -23.035-56.331-2O501.0059.03 A

ATOM 99 O GLUA 14 -23.608-55.241-26.3501.0058.05 A ATOM 100 N ALAA 15 -23.631-57.461-25.9841.0060.30 A

ATOM 101 CA ALAA 15 -25.062-57.520-25.712 1.0060.76 A

ATOM 102 CB ALAA 15 -25.545-58.963-25.7191.0060.85 A

ATOM 103 C ALAA 15 -25.400-56.850-24.3841.0060.99 A ATOM 104 O ALAA 15 -26.528-56.942-23.899 1.0060.97 A

ATOM 1Θ5 N GLYA 16 -24.414-56.177-23:801 1.0061.61 A

ATOM 106 CA GLYA 16 -24.556-55.612-22.533 1.0062.27 A

ATOM 107 C GLYA 16 -23.424-54.625-22.683 1.0062.79 A

ATOM 108 O GLYA 16 -22.839-54.377-21.7151.0062.-63 A ATOM 109 N ALAA 17 -23.110-54.087-23.858 1.0062.70 A

ATOM 110-CA ALAA 17 -22.156-52.941-23.9061.0061.93 A

ATOM 11-1 CB ALAA 17 -20.928 -53.040 -24.965 1.0060.66 A

ATOM 112 C ALAA 17 -23.242-52.108-24.461 1.0061.23 A

ATOM 113 O ALAA 17 -23.118-50.933-24,642 1.0061.49 A ATOM 114 N ALAA l* -24.327-52.803-24.7601.0059.81 A

ATOM 115 CA ALAA 18 -25.509-52.151-25.2541.0058.21 A

ATOM 116 CB ALAA 18 -26.264-52.991 -26.238 1.0058D7 A

ATOM 117 C ALAA 18 -26.239-52.164-23.9621.0057.70 A

ATOM 118 O ALAA 18 -27.130-51.390-23.718 1.0058.05 A ATOM 119 -N LEUA 19 -25.901-53.10-9-23.1051.0056.83 A

ATOM 120 CA LEUA 19 -26.707 -52.907^"-2L99 L 1.0057.00 A

ATOM 121 -CB LEUA 19 -27.011 -54.098 -2-hlT8 1.005£58 A

-ATOM 122 CG LEUA ϊ-9 -28.492-54.172-21.6751.0054.83 A

ATOM 123-CDlLEϋA 1-9- 38,948 -55.517- -.2L-470^" 1-:0054.26 A ATOM Ϊ24 CD2LEUA 19 -29.591 -53.120-21J821.0053.17 A

ATOM 125 C LEUA 19 -26.073 -"5-1.688 -2O75 1.0057.37 A

ATOM- 126 O LEUA 19 -26.780-50:864-20.8681.00-58:02 A

ATOM 127 N PHE A 20 -24.777-51.490-21.369 1.0056.49 A

ATOM 128 CA PHE A- 20 -24.340-50.220-20.7721.0056.21 A ATOM 129 CB PHEA 20 -22.885-49.940-21.231 1.0056.25 A

ATOM 130 CG PHEA 20 -22.408-48.547-20.9461.0057.66 A

ATOM 131 CDlPHEA 20 -21.068-48.311-20.788 1.0057.81 A

ATOM 132 CD2 PHE A 20 -23.289-47.480-20.813 1.0057.20 A

ATOM 133 CElPHEA 20 -20.625-47.043-20.4991.0058.41 A ATOM 134 CE2 PHE A 20 -22.874-46.235-20.532 1.0058.00 A

ATOM 135 CZ PHEA 20 -21.546-45.992-20.3701.0059.02 A

ATOM 136 C PHEA 20 -25.197-48.917-21.115 1.0055.56 A

ATOM 137 O PHEA 20 -25.435 -47.996 -2^Q.3 lft LOO 55.53 A, ATOM 138 N ALAA 21 -25.623.-48.851-22.3571.0054:98 A

ATOM G9 CA ALAA 21 -26.259-47.635-22.903 1.0054.22 A

ATOM 140 CB ALAA 21 -25.852-47.567-24.331 1.0053.01 A

ATOM 141 C ALAA 21 -27.704-47.165-22.819 1.0054.48 A

ATOM 142 O ALAA 21 -28.013-45.943-22.841 1.0052.93 A ATOM 143^' N ALA A 22 -28.571-48.152-22,803 1.0056.00 A

ATOM 144 CA ALAA 22 . -29.977 -47.945 -22.741 -1.0057.26 A

ATOM 145 CJB ALAA 22 -30.642 -49.3 H -22.6961.0056.96 A

ATOM 146 C ALAA 22 -30.145-47.184-21.445 1.0058.00 A

ATOM 147 O ALAA 22 -31.022-46.327-21.328 1.0057.47 A ATOM- 148 N ALAA 23 -29.266-47.492-20.4851,0058.67 A

ATOM 149 CA ALAA 23 -29.297-46.857-19.155 1.0058.69 A

ATOM 150 CB ALAA 23 -28.386-47.639-18.156 1.0057.91 A

ATOM 151 C ALAA 23 -28.875-45.385-19.2151.0058.54 A

ATOM 15ZO ALA A 23 -29.647-44.476-18.8721.0056.52 A ATOM 153 N ALAA 24 -27:639 -45J75 -19.6621.0058.70 A

ATOM 154 CA ALAA 24 -27.063-42.841-19.801 1.0058.13 A

ATOM- 155 CB ALA-A 24 -25.826 -43.901 -20.707 LΛ057.71 A

ATOM 156 C ALA A .2.4 -28.066 -42.842 -20.3.641,0057.71 A

ATΘM 157 O ALAA 24 -28.1=57 -4L706 -19.903 LOO 58.27 A ATOM 158 N ASMrA 25 -28.804-43.287-21,3701.0056.93 A

ATOM 159 CA AS-NA 25 -29:791 -42.465 -^"22.6301.0057.15 A

ATOM 160-CB ASNA25 -3O.407-43^".255 -23.161 1:0057.27 A

ATOM 161 CG ASNA 25 -31.630-42.633-23.655 1.0056.94 A

ATOM 162. ODl ASN-A 25 -31.660 -41.598 -24.345 1.0057.66 A ATOM 163 ND2 ASN A 25 -32.673-43.247-23.2791.0055.67 A

ATOM 164 C ASNA 25 -30.881-41.925-21.121 1.0057.64 A

ATOM 165 O ASNA 25 -31.237-40.749-21.1841.0056.82 A

ATOM 166 N ALAA 26 -31.394-42.792-20.2591.0059.06 A

ATOM 167 CA ALAA 26 -32.452-42.405-19.331 1.0059.31 A ATOM 168 CB ALAA 26 -33.017-43.640-18.654 1.0060.17 A

ATOM 169 C ALAA 26 -31.941-41.419-18.2841.0058.79 A

ATOM 170 O ALAA 26 -32.627-40.447-17.944 1.0057.60 A

ATOM 171 N SERA 27 -30.727-41.668-17.81⁾1 1.0058.05 A ATOM 172 CA SERA 27 -3D.103 -40.825 -16T7921.0057.97 A

ATOM 173 CB SERA 27 -28.934-41.575-16:16.0 1.0058.11 A

ATOM 174 OG SERA 27 -29.301-42.906-15.861 1.0059.45 A

ATOM 175 C SERA 27 -29.595-39.512-17.390 1.0057.80 A

ATOM 176 O SERA 27 -29.834-38/1 rS -16.848 1.0058.01 A ATOM 177^"N ALAA 28 -28.887-39.641-18.5081.0056.08 A

ATOM 178-CA ALAA28 -28.320--38.499-19.r941.0053.61 A

ATOM 179 CB ALA A- 28 -27.6S8 -38.935 -20.4681.0053.51 A

ATOM 180 C ALAA 28 -29.356-37.463-19.5161.0051.88 A

ATOM 181 O ALAA 28 -29.088-36.281-19.4561.0051.41 A ATOM 182 N GLUA 29 -30.559-37.866-19.861 1.0051.73 A

ATOM 183 CA GLUA 29 -31.452-36.787-20.1891.0053.31 A

ATOM 184 CB GLUA 29 -32.567-37.214-21.123 1.0054.89 A

ATOM 185 CG GLUA 29 -32.673-38.644-21.5181.0056.81 A

ATOM 186 CD GLUA 29 -34.066-38:886-21.991 1.0058.58 A ATOM 187 OEl GLUA 29 -34.386-39.997-22.4541.0058.69 A

AXOM 188 OE2 GLU-A 29- -34.849 -37.9B -21.883 1.0059.91 A

ATOM 189 C GLUA 29 -32:020-36.022-19.0071.0054,05 A

ATOM 199 O- GLU A 29 -32.801 -35.086-19.184 LOO 53.13 A

ATOM 191 N ALAA 30 -31.607-36.407-17.801 1.0055.82- A -ATOM 192 CA ALAA^~30 -32.03-3 -35:704 -16:588.1.0056.01 A

-ATOM 193 CB ALAA 30 -32.085 -36.672 -15389^' 1.00-56.45 A

ATΘM 194 C ALA A- 30- -30.9.L8_ -34.694 -16.4-14 1.0055τ85 A

ATOM 195 O ALAA 30 -31.131-33.483-16.3901.0055.26 A

ATOM 196 N VALA 31 -29.708-35.222-16.361 1.0054.68 A ATOM^" 197 CA VALA 31 -28.545-34.380-16.2161.0054.97 A

ATOM 198 CB VALA 31 -27.298-35.235-16.151 1.0054.56 A

ATOM 199 CGlVALA 31 -26.260-34.719-17.141 1.0054.88 A

ATOM 200 CG2 VAL A 31 -26.754-35.202-14.7751.0056.04 A

ATOM 201 C VALA 31 -28.350-33.341-17.326 1.0055.54 A _38?

ATOM 202 O VALA 31 -27.739-32.288-17.132 1.0056.50 A

ATOM 203 N LEUA 32 -28.825-33.666-18.514 1.0055.38 A

ATOM 204 CA LEUA 32 -28.692-32.745-19.628 1.0054.61 A

ATOM 205 CB LEUA 32 -28.810-33.477-20.9721.0054.42 A

5 ATOM 206 CG LEUA 32 -27.543 -34.183 -21,461 1.00-54.23 A

ATOM 207 CDlLEUA 32 -27.796-34.862-22.783 1.0054.55 A

ATOM 208 CD2 LEU A 32 -26.438-33.164-21.613 1.0054.71 A

ATOM 209 C LEUA 32 -29.764-31.676-19.516 1.0054.45 A

ATOM 210 O LEUA 32 -29.491-30.493-19.705 1.0054.37 A

10 ATOM 211 N PHEA 33 -30.979-32.095-19.188 1.0054.39 A

ATOM 212 CAPHEA 33 -32.086-31.16149.040- 1.0055.62 A

ATOM 213 CB PHEA_^33 -33.34-3 -31.897 -18J761.0053.45 A

ATOM 214 CG PHEA 33 -34.473-30.983-18.2041.0050.91 A

ATOM 215 CDlPHEA 33 -35.424-30.601-19.1401.0050.80 A

15 ATOM- 216 CD2PHEA 33 -34.587-30.508-16.911 1.0649:97 A

ATOM 217 CElPHEA 33 -36.481-29.757-18.790 1.0050.71 A

ATOM 218 CE2 PHEA 33 -35.631-29.667-16.551 1.0050-22 A

ATOM 219 CZ PHEA 33 -36.582-29.290-17.491 1.0050.76 A

ATOM 220 C PHEA 33 -31.724-30.103-18.0121.0057.68 A

20 ATOM 221 O PHEA 33 -31.996-28.909-18.195 1.0058.13 A

ATOM 222 N GLN A 34 -31.113 -30.554-16.921- 1.J8059.06 A

ATOM 223 CA GLNA 314 -3υ.7L8 -29.641 -15.851 LOO 69:03- A

AΪOM 224 CB GLNA 34 -30JD89--3&412 -14.683 L0061J25 A

ATOM 225 JCG GLN Λ- 34 -28.834 -31.180 -15^0241700-63.54 A

_J∑5 AFOM 226 GD GLNA 34- -27.-618 -30.683 -14.259^~r.0£-65.24 A

ATOM 227 -GEl GLN-A- 34- -27.752 -30.057 -13.20F 1.0066.46 A

ATOM 22^~8^~NE2 GLNA 34 -26.422-30:972-14.7761.ΘO6632_ A

ATOM 229 C GLNA 34 -29.746 -28_571 -16.3451.0059.36 A

ATOM 230 O GLNA 34 -30.064-273.74-1-6.3291.-0059.67 A

30 ATOM 231 N SERA 35 -28.574-29.008-16.7981.0057.45 A

ATOM 232 CA SERA 35 -27.557-28.091-17.2881.0055.94 A

ATOM 233 CB SERA 35 -26.396-28.869-17.9091.0056.33 A

ATOM 234 OG SERA 35 -26.497-28.867-19.3171.0058.75 A

ATOM 235 C SERA 35 -28.126-27.138-18.3271.0054.46 A _7OO

JOO

ATOM 2360 SERA 35 -27.733-25.979-18.3961.0054.01 A

ATOM 237 N VAL A 36 -29.053-27.638-19.134 1.0053.29 A

ATOM 238 CA VALA 36 -29.666-26.838-20.1841.0052.85 A

ATOM 239 CB VALA 36 -30.372-27.754-21.2081.0053.55 A ATOM 240 CGlVALA 36 -31.200-26.919-22.1981.00.52.79 A

ATOM 241 CG2 VAL A 36 -29.318 -23.579 -21.9551.0052.80 A

ATOM 242 C VALA 36 -30.651-25.782-19.6821.0052.27 A

ATOM 243 O VALA 36 -30.616-24.626-20.115 1.0051.72 A

ATOM 244 N ALAA 37 -3L530 -26.180 -18.771 1.0051.90 A ATOM 245 CA ALAA 37 -32.522-25.267-18.225 1.0050.68 A

ATOM 246 CB ALAA 37 -33.518-26.043-17.3721.0051.42 A

ATOM 247 C ALAA 37 -31.824-24.202-17.3961.0048.73 A

ATOM 248 O ALAA 37 -32.297-23.073-17.2881.0047.93 A

ATOM 249 N ALAA 38 -30.688-24.573-16.8201.0046.99 A ATOM 250 CA ALAA 38 -29τ917-23.649 -16.003 1.0045.75 A

ATOM 251 CB ALAA 38 -28.735 -24.3*1 -15.352 1.0045.32 A

ATOM 252 C ALA A 38 -29.421-22.521-16.8971.0044.93 A

ATOM 253 O ALAA 38 -29J72 -21.332 -16.585 1.0045.15 A

ATOM 254 N SERA 39 -28.833-22.906-18.0221.0043.20 A ATOM 255 CA SERA 39 -28.324-21.936-18.971 1.0040.74 A

ATOM 256 CB SERA 39 -27.673 -22.653 -20.146 L00-39.66 A

ATOM 257 OG SERA 39 -26.645-23.515-19.6891.0038.90 A

ATOM 2-58 C SER-A 39 -29.483-21.082.-19.452 1.0040.23- A

ATOM 259 O SERA 39 -29.399-19-859 -19.464- 1.0DT38.93 A AIOM 260 N TREA 40 -30,582-21.727-19.8191.0040.90 A

ATOM 261 CA-TRPA 40 -31.734 -2Q.5S3 -20.303 1,0042.94 A

ATOM 262 CB TRPA 40 -327937-21.907-20.548 1.0041.16 A

ATOM 263 CG TRPA 40 -34.174-21.153-20.9941.0039.70 A

ATOM 264 CD2 TRP A 40 -34.484 -20.701 -22.321 1.0040.08 A ATOM 265 CE2 TRP A 40 -35.701-19.983-22.2471.0040.58 A

ATOM 266 CE3 TRP A 40 -33.852 -20.827 -23.561 1.0039.88 A

ATOM 267 CDlTRPA 40 -35.181-20.708-20.2021.0039.94 A

ATOM 268 NEl TRPA 40 -36.104-20.004-20.9401.0040.46 A

ATOM 269 CZ2 TRP A 40 -36.304-19.393-23.371 1.0040.08 A _3g9

ATOM 270 CZ3 TRP A 40 -34.449-20.241-24.6741.0041.03 A

ATOM 271 CH2 TRP A 40 -35.666-19.532-24.568 1.0040.77 A

ATOM 272 C TRPA 40 -32.138-19.857-19.3661.0045.21 A

ATOM 2730 TRPA 40 -32.740-18.880-19.803 1.0044.61 A ATOM 274 N ALAA 41 -31.804 -19.988-18.084 LOO 48.17 A

ATOM 275 CA ALAA 41 -32.155-187958-17.1101.0050.90 A

ATOM 276 CB ALAA 41 -32.299-19.571-15.7291.0051.19 A

ATOM 277 C ALAA 41 -31.094-17.866-17.0921.0052.43 A

ATOM 278 O ALAA 41 -31.397-16.695-16.841 1.0052.3T A ATOM 279 N HISA 42 -29.852 -18.260 -17.368 LOO 53.67 A

ATOM 280 CA HISA 42 -28.744-17.314-17.395 1.00,55.62 A

ATOM 281 CB HISA 42 -27.396-18.053-17.3261.0057.10 A

ATOM 282 CG HISA 42 -26.203-17.141-17.245 1.0058.99 A

ATOM 283 CD2 HIS A 42 -26.108-15,807-17.024 1.0059.33 A ATOM 284 NDl HIS A 42 -24.909 -17.596 -17.388 1.0058τ92 A

ATOM 285 CElHISA 42 -24.070-16.583-17.2601.0058.60 A

ATOM 286 NE2 HIS A 42 -24.772-15.486-17.0391.0059.32 A

ATOM 287 C HIS A 42 -28.788-16.456-18.6561.0056.30 A

ATOM 288 O HISA 42 -28.494 -15.266 -1S.619 1.0057.04 A ATOM 289 N ASPA 43 -29.152-17.067-19.7761.0056.56 A

ATOM 290 CA^" ASPA 43 -29.21-6-16.345-21.0371.0056.37 A

ATOM 291 CB- ASP A 43- -29.175 -17.329 r22.208 1.0056.65^" A

ATOM 292 CG ASPA 43 .27.869-18.00-7-22.369 LQO 57.12 A

-ATOM 293 ODlASPA 43 -27.575-L8.671 -23.407 t.0056.94 A. ATOM 294 OD2ASPA-43 -26^959 -17τ&83 -21.460 L00-58:5β A-

ATOM 235 C ASPA 43 -30.467-15.474-21.0991.0056.87 A-

ATOWL 296 O- ASPA 43 -30.425 -14.350-21.5971.00156. LO A

ATOM 297 N THRA 44 -31.574-15.991 -20.578 LOO 58.07 A

ATOM 298 CA THRA 44 -32.825-15.247-20.5521.0059.63 A ATOM 299 CB THRA 44 -34.009-16.165-20208 1.0060.47 A

ATOM 300 OGl THRA 44 -33.770-16.790-18.9421.0063.10 A

ATOM 301 CG2 THR A 44 -34.187-17.227-21.2791.0061.08 A

ATOM 302 C THRA 44 -32.659-14.196-19.4601.0059.55 A

ATOM 303 O THRA 44 -33.361-13.184-19.441 1.005922 A _39Q

ATOM 304 N ASNA 45 -31.718-14.448-18.5491.0059.53 A

ATOM 305 CA ASNA 45 -31.437-13.497-17.4681.0059.47 A

ATOM 306 -CB ASN A 45 -32.333-13.734-16.2491.0059.32 A

ATOM 307 CG ASNA 45 -32.507 -12.478 -15.4101.0058.99 A ATOM 308 ODl ASNA 45 -31.803 -11.484-15.6111.0059.19 A

ATOM 309 ΗD2 ASN A 45 -33.444-12.515-14.4671.0058.59 A

ATOM 310 C ASNA 45 -29.988-13.537-17.0121.0059.07 A

ATOM 311 O ASNA 45 -29.539-14.523-16.4291.0059.02 A

ATOM 312 N ILEA 46 -29.401-12.863-17.5831.0058.87 A ATOM 313 CA ILEA 46 -28.001-12.779-17.1821.0058.66 A

ATOM 314 CB ILEA 46 -27.198-11.948-18:2001.0057.77 A

ATOM 315 CG2 ILE A 46 -27.378-10.461-17.9341.0057.17 A

ATOM 316 CGlILEA 46 -25.718-12.331-18.151 1.0056.18 A

ATOM 317 CDLDLEA 46 -25.058-12.392-19.5120.0057.21 A ATOM 31-8 C ILEA 46 -27.862-12.177-15.7881.0058L22 A

ATOM 319 O ILEA 46 -27.777-10.959-15.635 1.0057.94 A

ATOM 320 N THRA 47 -27.693~12.635 -14.4691.0057.81 Λ

ATOM 321 CA THR A 47 -27.526-12.177-13.089 1.0056.85 A

ATOM 322 CB THRA 47 -28v834 -12.296 -12.2491.0056.77 A ATOM 323 OGlTHRA 47 -29.087-13.670-11.9241.0057.04 A

ATOM 324 CG2 THRA 47^" -30.014-11.7-0-7-13.003 LOΘ 57.24- A

ATOM 325 C THRA 47 -26^44-13.040 -12.4451.0056:14 A

ATOM 326 O THRA 47 -26,157-14.150-12.9071.0055.58 A

ATOM 327- N ALA A 48 -25JB35. -12.523 -11.3861.00-55.00- A ATOM 328 CA ALAA 48 -2:4.777 -13.255 -10.705 LOO 53,75- A

ATOM: 329 CB ALAA 48" -24.202-12.397 -9:591 1.0054.35 A

ATOM 330- C ALAA 48 -253.05 -14τ575 -10.145 1.0052.50 A

ATOM 3310 ALAA 48 -24.610-15.596-1.0.1391.00-50.97 A

ATOM 332 N ALAA 49 -26.550.-14.538 -9.6801.0051.55 A ATOM 333 CA ALAA 49 -27.192-15.716 -9.1141.0050.20 A

ATOM 334 CB ALAA 49 -28.566-15.348 -8.5471.0050.91 A

ATOM 335 C ALAA 49 -27.336-16.823-10.153 1.0048.88 A

ATOM 336 O ALAA 49 -26.943-17.964 -9.903 1.0048.42 A

ATOM 337 N ASNA 50 -27.892-16.482-11.3171.0047.09 A ATOM 338 CA ASNA 50 -28.101-17.457-12.3921.0044.19 A

ATOM 339 CB ASNA 50 -28.880-16.811-13.5461.0043.82 A

ATOM 340 CG ASNA 50 -30.269-16.321-13.1271.0043.99 A

ATOM 341 ODlASNA 50 -3L.038 -17.062 -12.5301.0044.25 A ATOM 342 ND2 ASN A 50 -30.596-15.075-13.4581.0.043.69 A

ATOM 343 C ASNA 50 -26.779-18.026-12.9091.0042.3.8 A

ATOM 344 O ASNA 50 -26.686-19.215-13.2291.0040.58 A

ATOM 345 N ALAA 51 -25.761-17.170-12.9701.0041.33 A

ATOM 346 CA ALAA 51 -24.444 -17.567 -13.4461.0040.48 A ATOM 347 CB ALAA 51 -23.535-16.361-13.5351.0040.14 A

ATΘM ^~348 C ALAA 51 -23.837-48.586-12.5171.0040.81 A

ATOM 349-0 ALAA 51 -23.339-19.624-12.9471.0039.59 A

ATOM 350 N ARGA 52 -23.877-18.267-11.2271.0043.21 A

ATOM 351 CA ARGA 52 -23.326-19.156-10.2071,0044.52 A ATOM 352 CB ARGA 52 -23.426-18.468 -8.835 1.0044.64 A

ATOM 353 CG ARGA 52 -23.279-19,340 -7.599 LOG 45.72 A

ATOM 354 CD ARGA 52 -24.245-18.779 -6.531 1.0046,06 A

ATOM 355 NE ARGA 52 -25.208-19.793 -6.082 1.0047.42 A

ATOM 356 CZ ARGA 52 -26.533 -19.638 -5.9801.0Q47τθ4 A ATOM 357 NHl ARGA 52 -27.116-18.485 -6.2941.0045.47 A

AT-OM 358 NH2 ARG A 52 -27.280-20.665 -5.573 1.0046.47 A

ATOM- 359 C ARGA 52 -24,075-20.4-96-10:2761.004x11 A

ATOM _360- O- ARGA 52 -21.45Ψ-21.561 -10.2481.0044,68 A

ATOM- 361 N ARG-A_53 -25.399-20.429.-10.365 1-.0045L26 A^" AT-©M .362 CA ARGA 53 -26.201 -21.588 -1077421,0043.95 A

ATOM 363- CB-ARG-A 53 -27^32-21.163 -H.Θ76 1:00:45.64 A

ATOM 364 CG ARG-A 53 -28.284-20.292-10.015-1.0046.60 A

ATOM 365 CD ARGA 53 -29.796-20.429- -9.943 1.0047.86 A

ATOM- 366 NE ARGA 53 -30.302 -20.203- -8.5921.0048.80 A ATOM 367 CZ ARGA 53 -31.06.8-21.060 -7.931 1.0049.21 A

ATOM 368 NHlARGA 53 -31.422-22.207 -8.4941.0047.38 A

ATOM 369 NH2 ARG A 53 -31.482-20.772 -6.705 1.0050.59 A

ATOM 370 C ARGA 53 -25.583-22.323-11.9271.0044.69 A

ATOM 371 O ARGA 53 -25.008-23.401-11.768 1.0044.32 A _m

ATOM 372 N GLNA 54 -25.705-21.735-13.112 1.0043.71 A

ATOM 373 CA GLNA 54 -25.246-22.377-14.338 1.0043.15 A

ATOM 374 CB GLNA 54 -25.136-21.354-15.470 1.0044.86 A

ATOM 375 CG GLNA 54 -23.883-21.500-16.318 1.0044.60 A ATOM- 3% CD GLNA 54 -24.139-22.246-17.612 1.0045.81 A

ATOM 377 OEl GOT-A 54 -^"24.994 -21.850 -18:4041.0047.57 A

ATOM 378 NE2 GLN A 54 -23.400-23.328-17.8291.0045.59 A

ATOM 379 C GLNA 54 -23.906-23.073-14.1271.0043.18 A

ATOM 380 O GLN-A 54^" -23.713-24.212-14.5541.0042.37 A ATOM 381 N GLUA 55 -22.983 -22:382-13.4661.0043.70 A

ATOM 382 CA GLUA 55 -21.657-22.929-13.205 1.0044.28 A

ATOM. 383 CB GLUA 55 -20.766-21.880-12:538 1.0044.38 A

ATOM 384 CG GLUA 55 -20.582-20.611-13.3561.0044.72 A

ATOM 385- CD GLUA 55 -19.423-19.766-12.8671.0045.37 A ATOM 3M -OEl GLUA 55 -1S.326- -20.325 -12.653 1.0044.50 A

ATOM 387 OE2 GLU A 55 -19.607-18.542-12.6971.0045.64 A

ATOM 388 C GLUA 55 -21.738-24.178-12.334 1.0044.19 A

ATOM 3890 GLUA 55 -20.861-25.041-12.3861.0043.54 A

ATOM 390 N ALAA 56 -22.795-24.268-11.5341.0044.92 A ATOM 391 CA ALAA 56 -23.006-25.422-10.665 1.0045.61 A

ATOM^' 392 CB- ALA-A 56 -24.022 -25.082 -9.5671.0046.30 A

ATOM 393: C ALAA 56- -23.513 -26.584-11.513 1.0044τ94 A.

ATOM 394-O ALAA 56 -22.912-27.660-11.5291.0044.21 A

AXΘM- 395 N- ALAA 57 -24.619 -26.349 -12^171.0044.69 A ATOM^' 396 CA ALAA 57 -25.211-27.360-13.082 1.0045.11 A

ATOM 397 GB ALAA 57 -26τ364-26.727 -13τ9θl ITOO^" 44.21 A

ATOM- 398^G ALAA 57 -24.195 -27.999--14τθB^" 1.0044.68 A

ATOM 399 O ALAA 57 -24.258-29.200-14.321 1.0044.49 A

ATOM 400 N ALAA 58 -23,240-27.185-14.453 1.0043.83 A ATOM 401 CA ALAA 58 -22.178-27.643-15.3361.0043.50 A

ATOM 402 CB ALAA 58 -21.327-26.469-15.761 1.0044.16 A

ATOM 403. C ALAA 58 -21.318-28.667-14.6191.0043.33 A

ATOM 404 O ALAA 58 -20.916-29.684-15.1901.0043.20 A

ATOM 405 N LEUA 59 -21.042-28.382-13.351 1.0043.61 A ATOM 406 CA LEUA 59 -20.225-29.254-12.5161.0042.95 A

ATOM 407 CB LEUA 59 -20.026-28.614-11.1441.0042.23 A

ATOM 408 CG LEUA 59 -18.585-28.193-10.875 1.0040.98 A

ATOM 409 CDlLEUA 59 -18.517-27.382 -9.6021.0041.10 A

5 ATOM 410 CD2 LEU A 59 -17.712 -29.432 -10.795 1.004O.04 A

ATOM 411 C LEUA 59 -2K828 -30.641 -12369 1.0042748 A

ATOM 412 O LEUA 59 -20.101-31.638-12.291 1.0041.67 A

ATOM 413 N ALAA 60 -22.155-30.704-12.3361.0041.90 A

ATOM 414 CA ALAA 60 -22.835-31.981-12.2121.0041.74 A

10 ATOM 415 CB ALAA 60 -24.329-31.764-11.9691.0042.35 A

ATOM 416 C ALAA 60 -22.609-32.726-13.512 1.Q041.64 A

ATOM 4170 ALAA €0 -22.096-33.850-13.515 1.0040.27 A

ATOM 418 N SERA 61 -22.973-32.083-14.619 1.0041.39 A

ATOM 419 CA SERA 61 -22.804-32.686-15.933 1.0041.43 A

15 ATOM 420 CB SERA 61 -23.126-31.676-17.031 1.0040.99 A

ATOM 421 OG SERA 61 -24.497-31.315-16.991 1.0041.87 A

ATOM 422 C SERA 61 -21.381-33.179-16.0871.0041.70 A

ATOM 423 O SERA 61 -21.137-34.334-16.4461.0040.62 A

ATOM 424 N GLNA 62 -20.437-32.296-15.801 1.0043.19 A

20 ATOM 425 CA GLNA 62 -19.064-32.696-15.913 1.0045.73 A

ATOM 426 CB GLNA 62 -13:105 -31.612-15.462^" lτOO-45.73 A

ATOM 427 CG GLNA 62 -18.117 -30Λ40 -16.408 1.0046.55- A

ATΘM 42S.-CD GLN-A 62 -17.62S=-29.162 -15.775 1.004733. A

ATOM- 429 OEl-GLNA 62 -18-.177 -28.708 -14.783 1:0047.41 A

25 ATOM 430- NE2 GLN A 62_ -16.590-28,567 -16.3541.00*7.95 A

ATOM 431- C GLNA 62 -18.901-33.888-15.0771.0047.-66 A

ATOM 432 θ GLNA 62 -18.121 -34.761 -15.40& 1.0047.0Θ A

ATOM 433 N GLUA 63 -19.542-34.036-13.9541.0050.20 A

ATOM 434 CA GLUA £3 -19.062-35.314-13.6791.0052.62 A

3.0 ATOM 435 CB GLUA 63 -18.097-35.289-12.562 1.0054.56 A

ATOM 436 CG GLUA 63 -17.685-36.556-11.9581.0058.03 A

ATOM 437 CD GLUA 63 -17.809-36.278-10.551 1.0059.94 A

ATOM 438 OEl GLUA 63 -18.970-36.187-10.101 1.0061.15 A

ATOM 439 OE2GLUA 63 -16.771-36.029 -9-9181.0061.03 A _m

ATOM 440 C GLUA 63 -19.988-36.479-13.9161.0052.55 A

ATOM 441 O GLUA 63 -19.580-37.634-13.8591.0051.59 A

ATOM 442 N PHEA 64 -21.239-36.196-14.261 1.0052.30 A

ATOM 443 CA PHEA 64 -22.094-37.276-14.7171.0052.64 A ATOM 444 CB PHEA 64 -23.372-36.700-15.3381.0051.51 A

ATOM 445 CG PHEA 64 -24.255-37.720-15.9781.00-51.78 A

ATOM 446 CDlPHEA 64 -25.610-37.526-15.9921.0051.51 A

ATOM 447 CD2 PHE A 64 -23.759-38.868-16.5571.-0051.98 A

ATOM 448 CElPHEA 64 -26.477-38.444-16.557 LOO 51.64 A ATOM 449 CE2 PHE A 64 -24.633 -39.795 -17.130 LOO 51.76 A

ATOM 450 CZ PHEA 64 -25.986-39.583 -17.125- 1.0051.^"57 A

ATOM 451 C PHE A 64 -21.206-37.825 -L5.S08 T.0053.-72 A

ATOM 4520 PHEA 64 -20.912-39.020-16.0171.0053.78 A

ATOM 453 N ALAA 65 -20.768-36.918-16.791 1,0055.26 A ATOM 454 CA ALAA 65 -19.953-37.254-17.9771.0056.71 A

ATOM 455 CB ALAA 65 -19.560-35.985-18.7371.0057.10 A

ATOM 456 C ALAA 65 -18.707-38.029-17.645 1.0057.69 A

ATOM 457 O ALAA 65 -18.242-3-8.870-18.4241.0057.84 A

ATOM 458 N GLUA 66 -18.133-37.740-16.495 1.0058.63 A ATOM 459 CA GLUA 66 -16.945-38.484-16.1901.0060.42 A

ATOM 460 CB GLUA 66 -16.161 -37.898 -15.061 1.00-6QZSo A

ATOM 461 CG GEUA 66 -15.39T -39.036 -14.5031.0060.77 A

ATOM 462-CD GLUA 66- -14.405 -38.610 -13^554-1.0061.20 -A

ATOM 463-OE-1GLUAJG6 -14=830 -377967 -12.577 L0&6O4 A- ATQBKL 464 OE2 GLU A -66 -13.222-38.914r-13.799 LOO 60:91 A-

ATOM 465 C GLU-A-M- -17.247-39.894-15.7-701.TJ061.16 A

ATOM 466 θ GLUA 66 -16.520 -40:S38--16:0991.00-61.30 A

ATOM 467 N ALAA 67 -18.300-40.024-14.9871.0061.73 A

ATOM 468 CA ALA A.67 -18.649 -41.326 -14,4741.0062.62 A ATOM 469 CB ALAA 67 -19.872-41.225-13.6201.0063.91 A

ATOM 470 C ALAA 67 -18.860-42.331-15.5801.0063.11 A

ATOM 471 O ALAA 67 -18.136-43.325-15.671 1.0062.48 A

ATOM 472 N TRPA 68 -19.843-42.072-16.432 1.0063.76 A

ATOM 473 CA TRPA 68 -20.111-42.983-17.526 1.0064.31 A ATOM 474 CB TRPA 68 -21.397-42.608-18.2361.0065.74 A

ATOM 475 CG TRPA 68 -22.569-42.629-17.341 1.0067.83 A

ATOM 476 CD2 TRP A 68 -23.587-43.632-17.283 1.0068.47 A

ATOM 477 CE2 TRP A 68 -24.535 -43.208 -16.329 LOO 68.66 A ATOM 478 CE3 TRP A 68 -23.790-44.845-17.9441.00-68.37 A

ATOM 479 CDlTRPA 68 -22.912-41.684-16.4461.00-67.79 A

ATOM 480 NEl TRPA 68 -24.099-42.009-15.833 1.0068.45 A

ATOM 481 CZ2 TRP A 68 -25.675-43.954-16.0191.0068.62 A

ATOM 482 CZ3 TRP A 68 -24.917 -45.586 -T7.6401.0068.90 A ATOM 483 CH2 TRP A 68 -25.849-45.138-16.6841.0068.81 A

ATOM 484 C TRPA 68 -18.963-42.943-18.505 1.00-64.15 A

ATOM 4850 TRPA 68 -18.703-43.917-19.205 1.0064.58 A

ATOM 486 N GLYA 69 -18.277-41.807-18.5471.0063.97 A

ATOM 487 CA GLYA 69 -17.160-41.662-19.4501.0063.77 A ATOM 488 C GLYA 69 -16.124-42.723-19.165 1.0064.10 A

ATOM 489 O GLYA 69 -15.940-43:628-19.961 1.0064.16 A

ATOM 490 N ALAA 70 -15i469 -42.619 -18.013 1.0064.64 A

ATOM 491 CA ALAA 70 -14.425-43.562-17.6181.0064.54 A

ATOM 492 CB ALAA 70 -13.756-43.080-16.3361.0064.03 A ATOM 493 C ALAA 70 -14.932-44.986-17.4441.0064.69 A

ATOM 494 O ALA-A 70 -14J46 -45.937 -17.442 1.0064.25 A

ATOM 495^" N ALA A 71 -16.242-45.141-1772901.0065.27 A

ATOM 496 CA ALA A 71 -10.813 -4fc473 -17.140 1.00-66.11 A

ATOM 497 CB AEAA 71 -18.196-46.393-16.4941.0066.33 A ATOM 498_C ALAA 71 -w.9A2 -47:093 -1&5241.0066.37 -A

ATOM 499 O ALAA 71 -L6.369 -48.168 -18.7-74- 170067.22 -A

ATOM 500 N ALAA 72 -L7.6Q-9 -46.39ΗT- 19.422^" LOO 65.42 A

ATOM 501 CA ALAA 72 -17.779 -46.854 -20.799 LOO 64.12 A

ATOM 502 CB ALAA 72 -18.294-45.719 -21.6601.0063.27 A ATOM 503 C ALAA 72 -16.461 -47.358-21.3691.0& 63.86 A

ATOM 504 O ALAA 72 -16.423-48.243-22.2181.0063.68 A

ATOM 505 N LYSA 73 -15.375-46.781-20.8801.0063.50 A

ATOM 506 CA LYSA 73 -14.032-47.118-21.339 1.0063.59 A

ATOM 507 CB LYSA 73 -13.214-45.871-21.371 1.0063.67 A ATOM 508 CG LYSA 73 -14.055-44.659-21.1241.0062.79 A

ATOM 509 CD LYSA 73 -13.241-43.414-21.2171.0061.89 A

ATOM 510 CE LYSA 73 -11.783-43.760-21.4841.0061.13 A

ATOM 511 NZ LYSA 73 -11.152-42.709-22.2941.0060.99 A ATOM 512 C LYSA 73 -13.361-48.096-20.423 1.00-64.02 A

ATOM 513 O LYSA 73 -12.363 -48.731 -20.775 l^'.OO 63.61 A

ATOM 514 N ALAA 74 -13.909-48.176-19.2271.0064.83 A

ATOM 515 CA ALAA 74 -13.391-49.066-18.2321.0066.77 A

ATOM 516 CB ALAA 74 -14.368 -49.130 -17.0811,0067.19 A ATOM 517 C ALAA 74 -13.238-50.452-18.8381.0067.74 A

ATOM 518 O- ALAA 74 -12:227-51.134-18.653 1.0068.16 A

ATOM 519 N LEUA 75 -14.240-50.816-1-9.6261.0068.05 A

ATOM 520 CA LEUA 75 -14.325-52.154-20.179 1.0067.79 A

ATOM 521 CB-XEUA 75 -15.287-52.909-19.2571.0067.38 A ATOM 522 CG LEUA 75 -16.724--52324 -19.259^~ 1.0067.76 A

ATOM 523 CDlLEUA 75 -17.698-53.326-18.651 1.0067.93 A

ATOM 524 CD2 LEU A 75 -16.836 -51.003^~-18.496 l.OO 67.00 A

ATOM 525 C LEUA 75 -14.840-52.308-21.6161.0067.97 A

ATOM 526 O LEUA 75 -14.935-53.420-22.1481.0068.25 A ATOM 527 N TYRA 76 -15.205-51.193-22.2171.0067.63 A

ATOM 528 CA TYRA 76- -15.791-5.1.1-96-23,5471.0067.45 A

ATOM 5-29 CB TYRA 76 -17.10^-50.415-23.4821.00,66.43 A

ATOM 530 CG TYRA 76 -18.238 -5L161 -22τ876 LOO 65.1O A

ATOM 531 -CDiTYRA- 76 -19.424-56.505 -22.57-0 1.0O--65Ϊ04 A ATOM^* 532 -CEJ TYR-A 76 -20,485 -.5L 185-22.0471.00:65.02 A

ATCM- 533 -CD2 TYRA 76 -18.150-52:527-22.6411.0063.-96 A

ATOM 534 CE2JYRA 76 -19.201-53.209-22:1261.Θ0.64.56 A

ATOM 535 CZ TYRA 76 -20.368-52.535-21.828 1.0065.15 A

ATOM 536 OH TYRA 76 -21.438-53.200-21.3171.0065.27 A ATOM 537 C TYRA 76 -14.916 -50.561" -24.605 1.0067.64 A

ATOM 5380 TYRA 76 -15.378-50.241-25.704 1.0067.98 A

ATOM 539 N GLUA 77 -13.654-50.392-24.2771.0067.24 A

ATOM 540 CA GLUA 77 -12.730-49.715-25.1571.0066.62 A

ATOM 541 CB GLUA 77 -11.813-48.868-24.281 1.0066.19 A ATOM 542 CG GLUA 77 -11.801-47.398-24.618 1.0066.24 A

ATOM 543 CD GLUA 77 -10.442-46.942-25.127 1.0066.51 A

ATOM 544 OEl GLUA 77 -10.266 -45.720 -25.3581.0065J66 A

ATOM 545 OE2 GLU A 77 -9.552-47.812-25.295 1.0065.68 A ATOM 546 C GLUA 77 -11.865 -50-538 -26.1O41.0Θ 66.11 A

ATOM 547 O GLUA 77 -11.779-50.258-27.306 1.0066.92 A

ATOM 548 N PROA 78 -11.190-51.557-25.5671.0065.04 A

ATOM 549 CD PROA 78 -11.387-52.066-24.1961.0064.79 A

ATOM 550 CA PROA 78 -10.301 -52.432-26.3321.0064.64 A ATOM 551 CB PROA 78 -9.541-53.156-25.241 1.0064.36 A

ATOM 552 CG PROA 78 -10.623-53.375-24.2101.0064.57 A

ATOM 553- C PROA 78 -10.995 -53.393 -27.274 LJOO 64.83 A

ATOM 554 O PROA 78 -10.340-54.182-27.946 1.0065.36 A

ATOM 555 N ALAA 79 -12.315-53,31-2-27.331 1.0064.54 A ATOM 556 CA ALAA 79 -13.O83 -54.219-28.1641.0063.55 A

ATOM 557 CB ALA-A 79 -13.742-55.242-27.268 1.0062.91 A

ATOM 558 C ALAA 79 -14.134 -33.490 -29.0101.0063.17 A

ATOM 559 O ALAA 79 -14.581 -53.9-87 -30.061 1.0064.10 A

ATOM 560 N ALAA 80 -14.529 -52.307 -2S.549 1.0061.97 A ATOM 561 CA ALAA 80 -15.289-51.378-29.376 1.0061.45 A

ATOM .562 CB. ALA A 80 -15.519-50.072-28.632 1.0060.88 A

ATOM 5-63 C ALA A 80 -14.586 -51.12Θ -30.705 LQO 61.99 A

ATOM 564 O ALAA 80 -13.396-51.395.-30.852 1.00-62.53 A

ATOM .565 N ALAA-Sl -15.33.1 -50.589_-31.6.69^' 1.0061.92 A ATOM 566 CAALAA 81 -14.893 -50.582-33.0591. GO 61.96 A_

ATOM 567 ^"CB ALAA 81 -13.378 -59.468 -33.1371-.0Θ 61.75 A-

ATOM 568 C ALA-A 81 -15.000 -5k917 =33.78« 1.0061.56 A

ATOM 569 O ALAA 81 -14.546-52.054-34.9241.0062.16 A

ATOM 570 N ASNA 82 -15.604-52.899-31.1271.0060.14 A ATOM 571 CA ASNA 82 -15.754-54.231-33.701 1.0057.96 A

ATOM 572 CB ASNA 82 -14.841-55.365-33.231 1.0056.73 A

ATOM 573 CG ASNA 82 -13.632-55.549-34.1261.0056.35 A

ATOM 574 ODlASNA 82 -13.505-56.559-34.819 1.0056.37 A

ATOM 575 ND2 ASN A 82 -12.734-54.571-34.1171.0055.74 A _„.

ATOM 576 C ASNA 82 -17.209-54.566-33.391 1.0057.24 A

ATOM 577 O ASNA 82 -17.624-55.721-33.4861.0057.73 A

ATOM 578 N PHEA 83 -17.979-53.548-33.021 1.0056.99 A

ATOM 579 CA PHEA 83 -19.376 -53.738 _r32.6571.0057.23 A ATOM 580 CB PHEA 83 -19.798-52:596-31.7721.0057.59 A

ATOM- 581 CG^" PHEA 83 -19:390-52.755-30.3381.0057.94 A

ATOM 582 CDlPHEA 83 -18.182-53.387-29.979 1.0057.33 A

ATOM 583 CD2PHEA 83 -20.186-52.197-29.339 1.0057.07 A

ATΘM 584 CElPHEA 83 -17.778-53.448-28.623 1.0056.40 A ATOM 585 CE2 PHE A 83 -19.804 -52,246 -2&.6061.0055.90 A

ATΘM 586 CZ PHEA 83 -18.599-52.869-27.6371.0056.11 A

ATOM 587 C PHE A 83 . -20.350 -53.83O -33.818 1,00-5-7.13 A

ATOM 588 O PHEA 83 -20.619-52.842-34.498 1.0057.07 A

ATOM 589 N THRA 84 -20.922-55.005-34.0361.00-57.18 A- ATOM 590 CA THRA 84 -21.831-55.160-35.1591.0057.05 A

ATOM 591 CB THRA 84 -22.708-56.388-35.0321.0057.23 A

ATOM 592 OGlTHRA 84 -21.878-57.530-34.7721.0057.79 A

ATOM 593 CG2 THRA 84 -23.439-56.603-36.3551.0058.19 A

ATOM ^"594 C THRA 84 -22.712 -52L955 -35.3811.0057.07 A ATOM 595 O THRA 84 -22.663-53.356-36.442 1.0058.37 A

ATOM 396 N- ASPA 85 -23.517 -.53.593 -34.391 1.0056.74 A

ATΘM 59-rCAASPA 85 -24.419- -52.452 -34 J 161.0056.22 A

ATOM 598- CB ASP^A 85- -25.453 -52.538. -33v442 1.0055.86 A

-ATOM 599 CG ASPA 85 =26.417- -51.430 -33.518 00-56.41 A ^"ATOM 600 ΘB1ASPA 85 -27.256-51.3-16-32.6071.0056.72 A

ATOM 601 OD2ASPA «5- -26τ309 -50.670: -34.5-30 l.σθ^6.73 -A

ATOM 602 C ASPA 85 -23.678^{^}-51.128 -34.354- 1.0056.7J A

ATOM 603 O ASP-A 85 -23.998-50.349-33.4.751.0057.21 A

ATOM 604 N PROA 86 -22.797-50.779-35.3051.0056.57 A ATOM 605 CD PROA 86 -22.840-50.853-36.7701.0055.82 A

ATOM 606 CA PROA 86 -22.185-49.511-34.9471.0056.23 A

ATOM 607 CB PROA 86 -21.118-49.323-36.0191.0055.53 A

ATOM 608 CG PROA 86 -21.438-50.418-37.095 1.0055.37 A

ATOM 609 C PROA 86 -23.081-48.310-34.8081.0055.86 A _m

ATOM 610 O PROA 86 -22.620-47.285-34.3091.0056.01 A

ATOM 611 N GLNA 87 -24.334-48.384-35.2451.0055.30 A

ATOM 612 CA GLNA 87 -25.174-47.215-35.0191.0055.83 A

ATOM 613 CB GLNA 87 -26.599 -47.45^"! -35.4141.0055.96 A ATOM 614 CG GLNA 87 -27.487 -46.5 F6 -34.661 1.0057.12 A

ATOM 615 CD GLNA 87 -28r879 -46.601-35.1401.0059.30^" A

ATOM 616 OEl GLNA 87 -29.738-45.793-34.7771.0059.69 A

ATOM 617 NE2 GLN A 87 -29.133-47.593-35.980 1.0060.49 A

ATOM 618 C GLNA 87 -25.12» -47.140-33.498 1.0056.90 A ATOM 619 O GLNA 87 -25.775-46.322-32.8501.0057.65 A

ATOM 620 N AEAA 88 -24.313 -48.023. -32.918 1.0057.Θ5 A

ATOM -621 CA ALAA 88 -24.084-48.021 -3 L4781.0055.94 A

ATOM 622 CB ALAA 88 -24.544-49.336-30.8671.0055.95 A

ATOM 623 C ALA A- 8S -22.622-47.892-31.0641.0055.63 A ATOM 624 O ALAA 88 -22.310 -47.30T-30.0261.0057.66 A

ATOM 625 N ALAA 89 -21.730-48.442-31.881 1.0054.36 A

ATOM 626 CA ALAA 89 -20.296-48.313-31.649 1.0052.93 A

ATOM 627 CB ALAA 89 -19.534-49.113-32.6941.0051.44 A

ATOM 628 C ALAA 89 -20.015-46.819-31.5321.0052.73 A ATOM 629 O ALAA 89 -19.021-46.410-30.931 1.0052.78. A

ATOM 630 N ALAA 90 -.20.895 -46J309 -32.1101.0051.52 A

ATOM 631 CA ALA A.90- -20.737 -44.^"560 -32.081 MO 50.90 A

AXOM- 632 CB ALA'- A- 90 -20.946 -44.113 -33:5191.0051.86 A

ATOM 633 C -ALAA-90 -21.658-43.787-31.1421.00-50:84. A ATOM 6340 AXA-A 90 -2-1.851- -42.S81--31.3001.0051.24 A

ATOM 63^"5^~N- ILE A 9-1 -22.223 -44.488-30.165 I^'.OO 50.5-3- A

ATOM 636.CA ILEA- -91 -J22.889 -43.84&-29.0681.0049:17^" A

ATOM 637 CB ILEA 91 -24.T22 -44.495 -28τ4941.0046.88 A

ATOM. 638 CG2 ILE A 91 -24.602 -43.543 -27.4651.0046.59 A ATOM 639 CGlILEA 91 -25.269-44.668-29.4781.0044.52 A

ATOM 640 CDlILEA 91 -26.595-44.187-28.8781.0041.59 A

ATOM 641 C ILEA 91 -21.838-44.120-28.036 1.0049.69 A

ATOM 642 O ILEA 91 -21.419-43.207-27.359 1.0050.14 A

ATOM 643 N ILE A 92 -21.391 -45.374 -27.9271.0049.40 A ATOM 644 CA ILEA 92 -20.332-45.675-26.955 1.0050.37 A

ATOM 645 CB ILEA 92 -19.891-47.171-26.991 1.0049.88 A

ATOM 646 CG2 ELE A 92 -18.549-47.359-26.2841.0049.82 A

ATOM 647 CGlILEA 92 -20.969-48.035-26.3401.0048.92 A ATOM 648 CDlILEA 92 -20.564 -49.477 -26: 134^" 0.0049.37 A

ATOM 649 C ILEA 92 -19.121 -44.7-84 -27.247 LOO 51.04- A

ATOM 650 O ILEA 92 -18.445-44.288-26.333 1.0052.42 A

ATOM 651 N GLYA 93 -18.872-44.552-28.5271.0050.70 A

ATOM 652 CA GLYA 93 -17.768-43.695-28:909-1.0050.81) A ATOM 653 C GLYA 93 -17.985-42.235-28.5291.0050.28 A

ATOM 654- O GLY A 93 -17.033 -41.472 -28-.4061.00^9.86 A

ATOM 655 N ALAA 94 -19240 -41.845.-2J8.348 1.0050.58 A

ATOM 656 CA ALAA 94 -19.570-40.477-27.982 1.0051.89 A

ATOM 657 CB ALAA 94 -20.984 -40.151 -28.-4111.0051.92 A ATOM 658 C ALAA 94 -19.449-40.334-26.481 1-.0053.74 A

ATOM 659 O ALAA 94 -19.182-39.252-25.9641.0054.40 A

ATOM 660 N VALA 95 -19.652-41.443-25.780 1.0054.89 A

ATOM 661 CA VALA 95 -19.582-41.444-24.328 1.0054.72 A

ATOM 662 CB VALA 95 -20.411-42.604-23.755 1.0054.31 A ATOM 663 CGlVALA 95 -20.288-42.656-22.245 1.0054.24 A

ATOM 664 CG2 VAL A 95 -21.860 -42,4€2L-24J.-39 LQO 53.84 A

ATOM 665 C VALA 95 -18.149 -41.524 -23.83O 1.0054.72 A

ATOM 666 θ VAL A 95 -17τ800-40.924 -22?834- 1.00J5.23 A

ATOM _667 N ARGA 96 -17.316 -42.256--24.54:4~i70054.47 A ATΘM 668 CA ARGA 96 -15.931 -42.369 -247146- 1.0054.87 A

ATOMr 6€9^"CB ARG-A 96 -1^"5.29O -43.474 -2_4.986 1.0056.35 A

ATOM 670 CG ARGA 96- -13.835-43.317-25.170 UQ.0-58.18 A

ATOM 671 CD ARGA 96 -13.44S -43.578 -26.595 1.0059.96 A

ATOM 672 NE ARGA 96 -12.054-43.200-26.7441.0061.83 A ATOM 673 CZ ARGA 96 -11.609-41.953-26:6091.0062.57 A

ATOM 674 NHlARGA 96 -10.312-41.697-26.740 1.0062.33 A

ATOM 675- NH2 ARG A 96 -12.460-40.956-26381 1.0062.36 A

ATOM 676 C ARGA 96 -15.139-41.049-24.250 1.0054.38 A

ATOM 677 O ARGA 96 -13.950-40.981-23.9371.0054.27 A _m

ATOM 678 N THRA 97 -15.795-39.989-24.6821.0053.38 A

ATOM 679 CA THRA 97 -15.112-38.713-24.821 1.0052.51 A

ATOM 680 CB THRA 97 -14.970-38.465-26.3301.0051.49 A

ATOM 681 OGlTHRA 97 -13.672-38.901-26.741 1.0048.24 A

5 ATOM 682 CG2THRA 97 -15.214-37.056-26.711 1.0051.09 A

ATOM 683 C THRA 97 -15.872-37.664-23.9891.0053.04 A

ATOM 684 O THRA 97 -17.024-37.322-24.212 1.0053.38 A

ATOM 685 N ALAA 98 -15.152-37247-22.963 1.0052.64 A

ATOM 686 CA ALAA 98 -15.628-36.360-21.902 LOO 52.55 A

10 ATOM 687 CB ALAA 98 -14.984-36.808-20.6361.0052.72 A.

ATOM 688 C ALAA 98 -15.325-34:906-22.091 1.0052.30- A

ATOM 689 O ALAA 98 -16.146 -33.985 -22.0161,005L29 A

ATOM 690 N GLYA 99 -14.054-34.741-22.302 1.0052.04 A

ATOM 691 CA GLYA 99 -13.580-33.417-22.5461.0052.22 A

15 ATOM 692 C GLYA 99 -1Z863 -32.624-21.5291.00.52.13- A

ATOM 693 O GLYA 99 -11.639 -32.570 -21Jl 1 1.0051.86 A

ATOM 694 N SERAlOO -13.677-31.908-20.7901.0051.42 A

ATOM 695 CA SERA10Θ -13.188-31.055-19.793 1.0051.00 A

ATOM 696 CB SERAlOO -14.106-29.838-19.6691.0049.55 A

20 ATOM 697 OG SERA 100 -15.450-30.147-19.9621.0048.81 A

ATOM 698 C SERAlOO -13.298-31.948-18.6241.0051.43 A

ATOM 699 O SERAlOO -T2.419 -31.957 -17:791 LOO 5JL86 A

ATOM- 700- N ALAA-101 -14.377 -32.725 -18JL61 1.00-50:14^ A

ATOM 701 CA ALA A 101 -14JS3J-33.579-17.393^~l.-0047.82 A

25. ATΘM 702 CBzALA A-101 -15.784-34.417-17.4751.0.048.75 A

ATOM 703 C ALAAlOl -13.326~34-.465-- 17.1-291.0046.50 A

ATOM 704 O ALAArOl -13T3^~4Θ -3-5.278 -16.214 L-00^~46.74^" A

ATOM 705 N ASN A 102 -12.287-34.332-17.942 LOQ 44.75 A

ATOM 706 CA ASN-A 102 -1L.060 -35.081 -17.691 1.0043.44 A

30 ATOM 707 CB ASN A 102 -10322-35.473-18.963 1.0043.74 A

ATOM 708 CG ASN A 102 -11.210-36.051-19.9871.0044.01 A

ATOM 709 ODl ASNA 102 -11.041-37.203-20.3701.0043.33 A

ATOM 710 ND2 ASN A 102 -12.166-35.262-20.4601.0043.75 A

ATOM 711 C ASN A 102 -10.196-34.034-17.053 1.0042.22 A _4Q2

ATOM 712 O ASN A 102 -8.977-34.069-17.188 1.0041.27 A

ATOM 713 N LEU A 103 -10.836-33.072-16.405 1.0040.62 A

ATOM 714 CA LEU A 103 -10.105-31.972-15.799 1.0039.23 A

ATOM 715 CB LEU A 103 -10.599-30.644-16.351 1.0039.37 A

5 ATOM 716 CG LEU A 103 -10.160-30.028-17.6661.0038.85 A

ATOM 717 CDl LEUA 103 -10.861-28.674-17.773 1.0037.90 A

ATOM 718 CD2 LEU A 103 -8.643-29.815-17.688 1.0038.05 A

ATOM 719 C LEU A 103 -10.271-31.935-14.305 1.0038.39 A

ATOM 720 O LEUA 103 -11.377-31.967-13.803 1J00T37.59 A

10 ATOM 721 N PRO A 104 -9.167 -31.856 -13.5591.0037.81 A

ATOM 722 CD PROA 104 -7.749-31.682-13.9041.0037.24 -A

ATOM 723 CA PRO A 104 -9.382-31.816-12.1071.0037.20 A

ATOM 724 CB PRO A 104 -7.988-31.542-11.5541.0036.88 A

ATOM 725 CG PRO A 104 -7.247-30.932-12.7071.0038.49 A

15 ATOM- 726 C PROA 104 -10.427-30.755 -11.695 l.θθ 3699 A

ATOM 7270 PRO A 104 -10.628-29.751-12.3881.0037.20 A

ATOM 728 N ALA A 105 -11J03 -31.010-10.5761.0036.63 A

ATOM 729 CA ALAA 105 -12.160-30.128-10.058 LOO 36.46 A

ATOM 730 CB ALA A 105 -12.483-30,497 -8.605 1.0036.12 A

-20 ATOM 731 C ALAA 105 -11.865-28.628-10.1461.0036.11 A

ATOM 732 O ALA A.105 -12,683-27.855-10.6591.0035.43 A

ATOM 733. N ALA-A 106 -10.71-1-28.213 -9,6271.0033.30 A

ATOM 734 CA ALAA 10.6 -1Θ330 -26..8O1 -9.652 l.QO-33.85 A

.ATOM 735 CB ALA-A 106 -8.941-26.S16 -9.094 LOO 35.43^" A

25 ATOM 736 C ALA-A-106 -1-0.425 -26.249 -11.06-7- 1..GΘ 31.88 A

ATOM 737 O ALAAT06 -11.103 -25.257 -11.3141.0029r74 A

AIOM 73Ε^"N LYS A 107 -9.7L8 -26.904 -11.987- 1700-3038^" A

ATOM 739 CA LYS A 107 -9.685 -26.489 -13.391 1.0027.56 A

ATOM 740 CB LYS A 107 -8.733-27.392-14.173 1.0023.63. A

30 ATOM 741 CG LYS A 107 -7.260-27.013-13.9941.0019.92 A

ATOM 742 CD LYS A 107 -6.331-28.075-14.5501.0015.97 A

ATOM 743 CE LYS A 107 -4.924-27.552-14.6541.0015.18 A

ATOM 744 NZ LYS A 107 -3.996-28.619-15.053 1.0018.14 A

ATOM 745 C LYS A 107 -11.058-26.450-14.0621.0027.92 A ATOM 7460 LYS A 107 -11.311-25.596-14.9161.0029.42 A

ATOM 747 N ARG A 108 -11.945-27.361-13.6771.0028.11 A

ATOM 748 CA ARG A 108 -13.282-27.387-14.2391.0028.61 A

ATOM 749 CB ARG A 108 -14.038-28.631-13.7641.0029.33 A ATOM 750 CG ARG A 108 -13.308 -29.-938 -14.0291.003Q.42 A

ATOM 751 CD ARGA 108 -14.231-31.145-13.8851.0031.06 A

ATOM 752 NE ARG A 108 -13.464-32.382-13.743 1.0032.36 A

ATOM 753 CZ ARG A 108 -13.980-33.562-13.4071.0034.18 A

ATOM 754 NHl ARGA 108 -15.279-33.669-13.182 1.0034.81 A ATOM 755 NH2 ARG A 108 -13.197-34.634-13.271 1.0034.99 A

ATOM 756 C ARG A 108 -14.035-26,132-13.8371.0029.69 A

ATOM 7570 ARG A 108 -14.778-25.579-14.6371.0029.32 A

ATOM 758 N GLN A 109 -13.827-25.679-12.598 1.0031.97 A

ATOM 759 CA GLN A- 109 -14.497-24.481-12.084 1.0033.04 A ATOM 760 CB GLN A 109 -14.314-24.389-10.563 1.0034.4Q- A

ATOM 761 CG GLN A 109 -14.951-25.549 -9.805 1.0035.10 A

ATOM 762 CD GLN A 109 -14.527-25.611 -8.3481.0035.87 A

ATOM 763 OEl GLNA 109 -17.336 -25.751 -8.0371.0035.46 A

ATOM 764 NE2 GLN A 109- -1-5.500 -25.510 -7.445 1.0035.46 A ATOM 765 C GLN A 109 -13.939-23.251-12.8041.0032.59 A

ATOM 766 O GLNA 109 -14.673-22.322-13.158 1.0032.35 A

ATOM 767 N GLN-AIlO- -12.636 -23.281 -13.0481.0031.73 A

ATOM 768 CA GLNAITJO. -11.978 -22.210 -13.767 L00-31-.34 A

ATOM -769 -CB GLN-A ttθ_ -10,477 -22.507 -13τ8901.0028.95 A ATOM 770 CG GLN A UO -SL702 -22.363 -12.603. l.θθ-27.87 A

ATOM 771 CD GLN A HO -8-290 -22.880^" -12.722- 1.0028.42 A

ATOM 772 OElGLN-A-110 -7.683-22.801-13.7801.0028.48 A

ATOM 773 NE2 GLNA 110 -7.750 -23.4X)I -11.6241.0028.61 A

ATOM 774 C GLNAIlO -12.641-22.227-15.133 1.0031.98 A ATOM 775 O GLNAIlO -13.172-21.221-15.605 1.0031.72 A

ATOM 776 N TYRAlIl -12.643-23.403-15.7461.0032.60 A

ATOM 777 CA TYRAlIl -13.248-23.564-17.0581.0034.12 A

ATOM 778 CB TYRAlIl -13.377-25.053-17.4101.0036.50 A

ATOM 779 CG TYRAlIl -13.714-25.325-18.8641.0039.65 A _m

ATOM 780 CDl TYRA 111 -12.796-25.051-19.8771.0040.68 A

ATOM 781 CEl TYRA 111 -13.106-25.296-21.2191.0042.04 A

ATOM 782 CD2 TYR A 111 -14.956-25.853-19.229 1.0041.14 A

ATOM 783 CE2 TYRA 111 -15.277-26.099-20.566 1.0041.83 A ATOM 784 CZ TYRAlIl -14.350-25.820-21.553.1.0041.79 A

ATOM 785 OH TYRAlIl -14.671 -26.066 -22.868 LOO 41.16 A

ATOM 786 C TYRAlIl -14.622-22.896-17.089 1.0033.55 A

ATOM 787 O TYRAlIl -14.798-21.839-17.695 1.0034.14 A

ATOM 788 N ASN A 112 -15.580-23.494-16.3971.0032.92 A ATOM 789 CA ASN A 112 -1&939 -22.972 -16.3691.0032.95 A

ATOM 79Θ CB ASN A 112 -17.768-23.774-15.371 1.0033.90 A

ATOM 791 CG ASN A 112 -17.565-25.281-15.5201.0034.83 A

ATOM 792 ODl ASNA 112 -17.798-25.857-16.583 1.0034.33 A

ATOM 793 ND2 ASNA 112 -17.131 -_25.924 -14.4471.0035.16 A ATOM 794- C ASNA 112 -17.033 -21.481 -16.053 1..0033.18 A

ATOM 795 O ASNA 112 -17,943-20.795-16.525 1.0032.20 A

ATOM 796 -N ALA A 113 -16.098-20.974-15.2541.0033.47 A

ATOM. 797 CA ALA A 113 -16.113-19.553-14,906 1.0032.61 A

ATOM 798 CB ALAA 113 -15.066-19.262-13.838 1.0032.78 A ATOM 799 C ALA A 113 -15.837-18.724-16.160 1.0031.41 A

ATOM 800 O ALA-A 113 -16.593 -17.800-16.5D2 1.0032.12 A

ATOM 801 TS- XEUA 1T4 -14.746 -19.071- -16:839 I.θσ27.83 A

ATOM- 892 CA LEU A 114 -14.360-18.388-18.060 LOO 25.36 A

ATOM 803 CR LEUA 114 -13r221 -19:145 -1-8;729^LO0-2Q.78 A ATOM 8.04 CG LEUA 114 -11.936-19.084 -17.905 LOO 20.00 A

A-TΘM -80S^" CDl-LEU A 114 -10.921 -20:080 -18.403^' 1.0017.84 A

ATOM 806 CD2 EEU A 114 -11.358 -17.682-17.967 LOO 19.32 A

ATOM- 807 C LEUA 114 -L5..569 -18,301 -18.9901.0025.83 A

ATOM 808 O LEU A 114 -16.006-17,211-19.375 1.0024.72 A ATOM 809 N LEUA 115 -16.138-19.456-19.3071.0025.44 A

ATOM 810 CA LEU A 115 -17.282-19.474-20.191 1.0025.09 A

ATOM 811 CB LEUA 115 -17.868-20.892-20.2421.0022.86 A

ATOM 812 CG LEU A 115 -16.707-21.841-20.559 1.0022.27 A

ATOM 813 CDl LEUA 115 -17.167-23.220-20.998 1.0020.75 A ATOM 814 CD2LEUA115 -15.920-21.237-21.701 1.0023.17 A

ATOM 815 C LEUA 115 -18.301-18.432-19.7621.0026.31 A

ATOM 816 O LEU A 115 -18.549-17.448-20.453 1.0026.64 A

ATOM 817 N- SERA 116 -18.865 -18.631 -18.586 1.00.28.18 A A-TΘM- ^"818. CA- SERA 116 -19.857-17.708-18.0061.0029.09 A

ATOM 819 CB^" SER A 116 -19:923-17.912-16.481 1.0027.99 A

ATOM 820 OG SER A 116 -21.253-17.850-16.0291.0026.71 A

ATOM 821 C SERA 116 -19.522-16.240-18.235 1.0029.71 A

ATOIvI -822 O SERA 116 -20:331-15.389-18:662 1.0028.33 A ATOM 823 N ASN A 117 -18.290-15.961 -17.904 LOO 29.86 A

ATΘM 824 CA ASNA 117 -17.807-14.636-18.008 1.0030.30 A

ATOM 825 CB ASN A 117 -16.-541 -14.643 -17.358 1.0031.13 A

ATOM 826 CG ASN A 117 -16.675-14.626-15.950 1.0030.57 A

ATΘM 827_ ODl ASNA 117 -17.742-14.704-15.288 1.0030.40 A ATOM 828 NDTASN A- 117 -15.554-14.504-15.431 1.0028.88 A

ATOM 829 C ASNA 117 -17.677-14.045-19.365 1.0029.08 A

ATOM 830 O ASN A 117 -18.263-12.998-19.629 1.0028.16 A

ATOM 831 N MET A 118 -16.931-14.728-20^30 1.0028.60 A

ATOM 832 CA META 118 -16.772-14.274-21.5971.0026.45 A ATOM 833 CB MET A 118 -16.073-15.340-22.425 1.0024.14 A

ATOM 834 CG MET A 11-8 -14.662 -15.604 -.21.9771.0025.25 A

ATOM 835 SD META 11Ε- -13.642-467513 -23.180 1-.Θ025JL4 A

ATOM 836 CE MET A 118 -14.302 -18.087 -23.099 LOΘ'25.54 A

ATOM ^"837 C META 118 -18.123 -13-M6 -32.2151,0026:89 A - ATOM^" -838^" O META IiS- -18.306 -12.871 -22.777 1.0027.45 A

ATOM- S39 N SER A 11-9- -IP J077 -14.-857 -22J021.0Θ-27.48 A ATOM^" 840-CA SERA 119 -20.390 -14.610 -^"22.675 1.0030:58 A

ATOM 841 CB SERA 119 -21-.296 -15.824 -22.475 1.0032.63 A

ATOM 842 OG SER A 119 -21.704-15.921-21.1261.0037.97 A ATOM 843 C SERA 119 -21.033-13.392-22.028 1.0030.62 A

ATOM 8440 SERA 119 -21.890-12.736-22.626 1.0031.15 A

ATOM 845 N ARG A 120 -20.615-13.101-20.800 1.0030.91 A

ATOM 846 CA ARG A 120 -21.159-11.972-20.0581.0030.98 A

ATOM 847 CB ARG A 120 -20.944-12.166-18.5501.0030.70 A _m

ATOM 848 CG ARGA 120 -21.749-11.203-17.663 1.0029.32 A

ATOM 849 CD ARGA 120 -20.832-10.247-16.9421.0029.17 A

ATOM 850 NE ARGA 120 -19.808-10.977-16.2091.0028.61 A

ATOM 851 CZ ARGA 120 -18.607-10.489-15.9291.0029.37 A ATOM 852 NHl ARG A 120 -18:276- -9.265 -16.3171.0029.24 A

ATOM 853 NH2 ARG A 120 -17.730-11.232-15.273^" 1.00-29.99 A

ATOM 854 C ARG A 120 -20.482-10.702-20.525 1.0030.48 A

ATOM 855 O ARG A 120 -21.134 -9.685-20.782 1.0030.02 A

ATOM 856 N ILE A- 121 -Ϊ9: 164-10.765-20.638 1.0029:89 A ATOM 857 CA ILE A 121 -18.419 -9.611-21.0971.0031.06 A

ATOM 858 CB ILE A 121 -16.924 -9:886-21.122 L00^"31.12 A

ATOM 859 GG2 ILEA 121- -16.210 -8.762-21.858 1.003U-2 A

ATOM 860 CGl ILE A 121 -16.413-10.048-19.6891.0032.35 A

ATOM 861 CDl-ILEA 121 -14.939-10.367-19.57-81.0031.48 A ATOM- 862 C ILEA 121 -18.866 -9.278 -22.5U5 1.0031.73 A

ATOM 8630 ELE A 121 -19.059 -8.111-22.8371.0031.72 A

ATOM 864 N TYR A 122 -19.048-10.307-23.3241.0031.76 A

ATOM 865 CA TYRA 122 -19.468-10.086-24.695 1.0031.15 A

ATOM 866 CB TYR A 122 -19.417-11.383-25.5091.0031.20 A ATOM 867 CG TYR A 122 -19.983-11.161-26.899 1.0032,03 A

ATOM 868 CDl TYRA 12T -19-.133 -11.092 -27τ990 1.0032.57 A

ATOM 869 CEl TYRA 122 -19.606^-10=771 -297249^" 1.0032.08 A-

ATOML 870 CD2 TYRA 122 -21.359 -10-903 -27.108 1.0Q 3-1.52 A

ATOM ^"871 CE2 TYRA 122- -21:847 -10.572 -28.3641.0032.46 A- ATOM- 872- CZ TYRA 122 -20.961-10.5-10-2974331.0031.76 A ATOM- 873 OH- TYRA 122 -21.436-10.208-30.683 bOO 30.56 A

ATOM 874- C TYRA 122 -20:882 --9L5&5 -24.813 1.0030.35 A

ATOM -875.0 TYRA 122 -21.249 -8.895-25.755 1.003CL-21 A

ATOM 876 N SERA 123 -21.-695 -9.982 -23.870 1.0029.28 A ATOM 877 CA SER A 123 -23.087 -9.635-23.983 1.0029.42 A

ATOM 878 CB SER A 123 -23.911-10.853-23.6301.0029.27 A

ATOM 879 OG SER A 123 -24.057-11.678-24.763 1.0029.72 A

ATOM 880 C SERA 123 -23.533 -8.505-23.1321.0029.76 A

ATOM 881 O SERA 123 -24.714 -8.157-23.0571.0029.80 A _40?

ATOM 882 N THR A 124 -22.563 -7.902 -22.507 1.0029.70 A

ATOM 883 CA THDR. A 124 -22.880 -6.875 -21.588 1.00 30.41 A

ATOM 884 CB THR A 124 -22.293 -7.287 -20.253 1.00 29.96 A

ATOM 885 OGl THR A 124 -22.968 -8.463 -19.807 1.00 3O.80 A

^"5 ATOM 886 CG2 THR A 124 -22.430 -6.209 -19.253 1.60-31.28 A

ATOM 887 C THR A 124 -22.332 -5.56S--22.032 LOO 30.72 A

ATOM 888 O THR A 124 -22.779 -4.537 -21.578 1.00 32.11 A

ATOM 889 N ALA A 125 -21.381 -5.627 -22.956 1.00 31.07 A

ATOM 890 CA ALA A 125 -20.678 -4.437 -23.437 1.00 30:99 A 0 ATOM 891 CB ALA A 125 -19.518 -4.835 -24.258 1.00 30.11 A

ATOM 892 C ALA A 125 -21.433^" -3.354 -24.149 1.Θ031.O9 A

ATOM 893 O ALA A 125 -22.514 -3.53.5 -24.711 LOG 31.68 A

ATOM 894 N LYS A 126 -20.797 -2.205 -24.161 1.00 30.71 A

ATOM 895 CA LYS A 126 -21.459 -1.083-24.721 1.00 31.56- A 5 ATOM 896 CB LYS A 126 -22.425 -0J79 -23.653 1.0030.91- A

ATOM 897 CG LYS A 126 -23.373 -1.700 -23.207 1.00 31.33 A

ATOM 898 CD LYS A 126 -24.025 -1.440 -21.890 1.00 32.37 A

ATOM 899 CE LYS A 126 -24JO38 -2.678 -21.057 0.00 32.09 A

ATOM 900 NZ LYS A 126 -24.632 -2.470 -19.733 0.00 32.24 A 0 ATOM 901 C LYS A 126 -20.554 0.007 -25.202 1.00 32.76 A

ATOM 902 O LYS A 126 -19.381 0.077 -24.825 1.ΘO3-1.52 A.

ATOM 903 N VAL A 127 -2X123 0.870 -26.035 1.00 34.50 A

ATOM 904- CA VAL A-127 -20.373 1.971-26=596 1.0037:00 A

ATOM 905 CB VAL A 127 -20.379^" 1.889 -28.133 LGO 35:10- A 5 .ATOM 906 €Gl VAL A 127 -19.691 3.078 -28.714 1:00 33:99 A

ATOM 907 CG2ΛiAi A 127 -1-9,665 0.624--287587 1.0032.59 A

ATOM 908^" C VAX A 127 -20.961 3.299 -26.119 1.00 39:73 A

ATOM 909 O VALA 127 -22.137 3.588 -26320 1.00 39.69 A

ATOM 910 N CYS A 128 -20.113 4.111 -25J05 1.00 43.32 A 0 ATOM 911 CA CYS A 128 -20.508 5.393 -24.976 1.00 47.48 A

ATOM 912 C CYS A 128 -19.956 6.554 -25.770 1.0048.88 A

ATOM 913 0 CYS A 128 -18.844 6.508 -26.270 1.0048.40 A

ATOM 914 CB CYS A 128 -20.049 5.451 -23.555 1.0049.83 A

ATOM 915 SG CYS A 128 -20.776 4.086 -22.623 1.00 55.22 A _...

4Uo

ATOM 916 N LEU A 129 -20.747 7.623-25.8571.0051.57 A

ATOM 917 CA LEU A 129 -20.334 8.805-26.6181.0055.24 A

ATOM 918 CB LEU A 129 -21.538 9.580-27.073 1.0055.39 A

ATOM 919 CG LEUA 129 -22.422 8.755-28.0141.0056.38 A

-5 ATOM 920 CDl LEUA 129 -23,089 7.601-27.246 1.0056.02 A

ATOM 921 CD2LEUA129 -23.481 9.642-28.658 1.0057.79 A

ATOM 922 C LEUA 129 -19.360 9.661-25.8091.0057.59 A

ATOM 923 O LEUA 129 -19.487 9.809-24.605 1.0058.55 A

ATOM 924 N PROA13O -18.406 L0.295 -26.485 1.0059.83 A 0 ATOM 925 CD PRO A 130 -18.51710.689-27.901 1.0060.44 A

ATOM 926 CA PRO A 130 -17.40.011.111-25.866 1.0061.74 A

ATOM 927 CB PRO A 130 -16^1911.950 -X6.928 1.0061.76- A

ATOM 928 CG PRO A 130 -17.13811.216-28.1741.0061.53 A

ATOM 929 C PROA 130 -17.71612.031-24.6401.0063.28 A 5 ATOM 93-00 PROA 130 -17.281 11.859-23.504 LQO 63.45 A

ATOM 931 N ALAA 131 -18.51013.053-24.942 1.0064.71 A

ATOM 932 CA ALA A 131 -18.609 14.226-24.082 1.0066.21 A

ATOM 933 CB ALA A 131 -18.670-15.494-24.920 1.0066.52 A

ATOM 934 C ALA A 131 -19.82214.136-23.1621.0066.85 A 0 ATOM 935 O ALA A 131 -19.683 14.013-21.9461.0066.28 A

ATOM 936 N ALA A 132 -21.012 14.197-23.7521.0068.26 A

ATOM 937- CA ALAA 132 -22.133 133^"8-I -23.303 1.0069.42 A

ATOM 918 CB-ALA A L32 -23.18813.281-24.395-1.00-69-09 A-

ATOM 939 C ALA A 132 -21.61-71-2.023 -2Z5381.68-69.77 A^{^} 5 ATOM 940 O- ALA A 132 -21.095 1L342 -23.633 1.0070.34 A

ATOM -941 N ALA-A 133 -21.77011.749-21.5471.0069,8-7 A

ATOM 942 CA ALA A 133 -22.040^~LO.395 -21.080 IDO 70.19 A

ATOM 943 CB ALA A 133 -2L43610.179-19.7001.0070.10- A

ATOM 944 G ALA A 133 -23.53810J 06 -21.058 1.0070.40 A 0 ATOM 945 O ALA A 133 -24.161 10.088-19.9971.0070.65 A

ATOM 946 N ALAA 134 -24.109 9.880-22.2371.0070.17 A

ATOM 947 CA ALA A 134 -25.524 9.546-22.351 1.0069.70 A

ATOM 948 CB ALA A 134 -26.38010.782-22.119 1.0069.51 A

ATOM 949 C ALA A 134 -25.837 8.926-23.7091.0069.25 A _m

ATOM 950 O ALAA 134 -25.042 9.021-24.643 1.0070.20 A

ATOM 951 N ALAA 135 -27.001 8.292-23.810 1.0067.73 A

ATOM 952 CA ALAA 135 -27.148 6.894-23.422 1.0065.83 A

ATOM 953 CB ALA A 135 -26.762 6.705-21.963 1.0065.40 A ATOM 9-54 C ALAA 135 -26.315 5.982-24.3171.0064.73 A

ATOM 955- O ALAA 135 -26.643 5.775-25.486 1.0065.30 A

ATOM 956 N CYS A 136 -25.237 5.440-23.761 1.0062.28 A

ATOM 957 CA CYS A 136 -24.555 4.305 -24.362 1.0059.58 A

ATOM 958 C CYS A 136 -25.315 3.200-25.1561.0058.66 A ATOM 9590 CYS A 136 -26.171 2.482 -24.621 1.0Θ 58.93 A

ATOM 960 CB CYS A 136 -23.720 3.624-23.205 1.0058.39 A

ATOM 961 SG CYS A 136 -22.703 4.590-22.123 1.0057.13 A

ATOM 962 N TRPA 137 -24.882 3.041-26.405 1.0057.33 A

ATOM 963: CA TRP A 137 -25.416 2.084-27.354 1.0055.29 A ATOM 964 CB TRP A 137 -24.856 2.426-28.7621.0055.54 A

ATOM 965 CG TRP A 137 -25.347 3.733-29.2941.0055.97 A

ATOM 966 CD2 TRP A 137 -24.702 4.585-30.259-1.0056.45 A

ATOM 967 CE2 TRP A 137 -25.568 5.673-30.498 1.0056.60 A

ATOM 968 CE3TRPA137 -23.482 4.533-30.946 1.0056.71 A ATOM 969 CDl TRPA 137 -26.533 4,325-29.001 1.0056.63 A

ATOM 970 NEl TRPA-137 -26.6.76 5.48S -29.717 1.0056.96 A

ATOM 971 CZ2 TRP A 137 -55.258 6.704 -3 f.393 LOO 56.89 A

ATOM 972 CZ3 TRPA B7 -23.173 5.564-31.841 LOΘ-57.33- A

ATOM -973_eH2TRPA 137 -24.06-1 6.633 -32.052^" T.OΘ 57.24- A ATOM 974 C TRP A 137 -25_;044.0.644 -27.056 Lτ30:53.50 A

ATOM ^~W5 O TRP A- 1-37 -24.022 0.371-26.4251.00-53.13 A

ATOM -9-76 J» SERrA 138 -25.869 -07284-27.521 L0052.il A

ATOM 977 CA SERA 131 -25.619 -1.704-27.325 1.0051.83 A

ATOM 978 CB- SERA 138 -26.685 -2.325-26.435 1.0052.70 A ATOM 979 OG SER A 138 -27.904 -2.414-27.145 1.0055.57 A

ATOM 980 C SERA 138 -25.649 -2.413-28.673 1.0051.08 A

ATOM 9810 SERA 138 -26.292 -1.954-29.6181.0050.92 A

ATOM 982 N LEU A 139 -24.959 -3.539-28.753 1.0049.66 A

ATOM 983 CA LEU A 139 -24.935 -4.302-29.9801.0048.88 A ATOM 984 CB LEU A 139 -23.964 -5.477-29.8361.0047.24 A

ATOM 985 CG LEUA 139 -23.597 -6.235-31.103 1.0046.78 A

ATOM 986 CDl LEUA 139 -22.823 -5.284-31.9831.0045.80 A

ATOM 987 CD2 LEU A 139 -22.755 -7.464-30.7841.0047.30 A ATOM 988 C LEU A 139 -26.323- -4.550 -30.270 1.0049.46 A

ATOM 989 O LEU A 139 -26.671 -5.105-31.413 1.0049.68 A

ATOM 990 N ALA A 140 -27.112 -5.034-29.219 1.0050.16 A

ATOM 991 CA ALA A 140 -28.451 -5.617-29.353 1.0049.80 A

ATOM 992 CB ALA A 140 -29.218 -5.504-28.0201.0051.01 A ATOM 993 C ALAA 140 -29.273 -5.063-30.5161.0049.74 A

ATOM 994 O ALA A 140 -29.621 -5.809 -3L4271.0049.73 A

ATOM 995 N PRO A 141 -29.677 -3.786-30.455 1.0049.57 A

ATOM 996 CD PRO A 141 -30.252 -3.384-29.1591.0049.40 A

ATOM 997 CA PROA-141 -30.447 -J.171 -31.5371.0049.59 A ATOM 998 CB PRO A 141 -31.752 -J2.795-30.846 1.0050.03 A

ATOM 999 CG PRO A 141 -31.313 -2.403-29.518 1.0049.63 A

ATOM 1000 C PROA 141 -29.713 -1.959-32.1181.0048.93 A

ATOM 1001 O PROA 141 -29.634 -1.805^"-33.3301.0050.04 A

ATOM 1002 N ASP A 142 -29.149 -K126-31.2451.0047.84 A ATOM 1003 CA ASPA 142 -28.451 0.102-31.642 1.0045.95 A

ATOM 1004 CB ASPA 142 -27.953 0.827-30.394 1.0047.99 A

ATOM 1005 CG ASP A 142- -28.988 0:845-29.281 1.0049,73 A

ATOM 1006 ODl ASP A 142 -30.132 1.287 -29.5281.0051.6ϋ A

ATOM lOOr OD2 ASP A 142 -28:653_rθ.41.8-28.1551.0049.4& A ATOM 1008 C ASP A 142 -27.297 -CLΘ04 -32.635 1.0043.20 A

A-TOM 1O09 Θ ASPAT42 -27.419- 0.433 =33.7761.0043τ55 A

ATOM 1010 N L-EUA 143 -26.169 -Q.553 -32:197^" 1.0040.08 A

ATOM 1011 CA LEUA 143 -25.001 -0.686-33.064 1.0037.74- A

ATOM 1012 CB LEUA 143 -23.891 -1.462-32.3601.0034.72 A ATOM 1013 CG LEUA 143 -23.259 -0.832-31.123 1.0031.59 A

ATOM 1014 CDl LEU A 143 -22.051 -1.646-30.7361.0029.43 A

ATOM 1015 CD2 LEU A 143 -22.850 0.598-31.4041.0028.49 A

ATOM 1016 C LEU A 143 -25.344 -1.394-34.368 1.0037.65 A

ATOM 1017 O LEUA 143 -24.937 -0.978-35.4601.0037.85 A _4U

ATOM 1018 N THRA 144 -26.093 -2.479-34.253 1.0036.54 A

ATOM 1019 CA THRA 144 -26.465 -3.199-35.441 1.0034.89 A

ATOM 1020 CB THRA 144 -27.353 -4.382-35.0821.0033.23 A

ATOM 1021 OGl THRA 144 -26.516 -5.503-34.765 1.0030.52 A

5. ATOM 1022^" CG2 THRA 144 -28.275 -4.725 -36.2251.0032.24. A

ATOM 1023 C THRA144 -27.139 -2.270-36.451 1.0036.22 A

ATOM 1024 O THRA 144 -26.656 -2.118-37.570 1.0038.14 A

ATOM 1025 N ASN A 145 -28.229 -1.620-36.059 1.0036.29 A ATOM^" 1026- GA ASNA 145 -28.917 -0:716 -36.978 1.0036.94 A 0 ATOM 1027 CB ASNA 145 -30.107 -0.048-36.2841.0036.39 A

ATOM 1028. CG ASN A 145 -31.132 -1.053-35.805 1.0037.49 A

ATOM iσ29 ODlASNA 145 -3-1.245 -2.166 -36.340 LQO 36.66 A

ATOM 1030 ND2 ASN A 145 -31.894 -0.667-34.7921.0038.83 A

ATOM 1031 C ASNA 145 -28.008 0.356-37.5971.0037.57 A. 5 ATOM 1-032^" O ASN A- 145 -28.090 0.649-38.8021.0038.81 A

ATOM 1033 N ILEA 146 -27.119 0.922-36.7881.0036.82 A

ATOM 1034 CA ILEA 146 -26.222 1.965-37.2861.0036.01 A

ATOM 1035 CB ILEA 146 -25.309 2.486-36.1681.0034,71 A

ATOM 1036 CG2 ILE A 146 -24.516 3.682-36.6571.0034.63 A 0 ATOM 1037 CGl ILE A 146 -26.159 2.924-34.9821.0034,08 A

ATOM 1038 CDl ELE A 146 -25.375 3.485 -33.828 1.0033.07 A

ATOM- romc ILE A 146 -25354 1.433 -3J8L411 1.0035.41 A

ATOM 1040 O_-ELEA-146 -24.983 2.149-39.345 1.0035.77 A

ATOM -1041 N LEUA 14? -25.022 0.161 -3&3Ϊ3.1.0034-.3S _A 5- ATOM 1G42- CA -LEILA 147 -24.204 -0.403 -39.342 LO034.05 _A

ATOM 1043-GB- LEUA 147 -23.5T4 --b648~38.824 ±0032.6f A

ATOM iσ44-CG LEUA-147 -22.003- -1.510 -38.915 1.0333,02 A

ATOM 1045 CDl-LEUA 147 -21.421 -0.418-38.015 1.0031.79 A

ATOM 1046 CD2 LEU A 147 -21.478 -2.784-38.473 1.0032.73 A 0 ATOM 1047 C LEUA 147 -25.092 -0.726-40.521 1.0034.79 A

ATOM 1048 O LEUA 147 -24.792 -0.397-41.6671.0035.46 A

ATOM 1049 N ALA A 148 -26.223 -1.338-40.2181.0035.40 A

ATOM 1050 CA ALA A 148 -27.167 -1.732-41.2441.0034.95 A

ATOM 1051 CB ALAA 148 -28.346 -2.455-40.6171.0035.35 A ^

ATOM 1052 C ALA A 148 -27.680 -0.605-42.123 1.0034.91 A

ATOM 1053 O ALAA 148 -27.930 -0.840-43.3021.0037.26 A

ATOM 1054 N SERA 149 -27.818 0.612-41.601 1.0033.14 A

ATOM 1055 CA SERA 149 -28.365 L669 -42.4401.0032.52 A ATOM 1056-GB-SERA 149- -29.876 1.687-42.2521.0034.30 A

ATOM 1-057 OG SERA 149- -30.188 1.731-40.873 1.0038.20 A

ATOM 1058 C SERA 149 -27.814 3.092-42.3391.0030.72 A

ATOM 1059 O SERA 149 -28.361 4.022-42.9351.0031.13 A

ATOM 1060 N SER-A 150 -267734 3,277-41.6041.0028:71 A ATOM 1.061 CA SERA 150 -26.163 4.604^" -41.503 1.0Q 27.40 A

ATOM 1062 GB SERA150 -25.491 47807-40:1461.0026.71 A

ATOM 1063- QG SERA 150 -24.59S 5.9t)7 -40.196 LOO 26.34 A

ATOM 1064 C SERA 150 -25.115 4.751-42.5821.0027.16 A

ATOM 1065 O SERA 150 -24.297 3.861-42.7691.0025.96 A ATOM 1066 N ARGA 151 -25.141 5.872-43.299 1.0027.54 A

ATOM 1067 CA ARGA 151 -24.131 6.106-44.333 1.0027.72 A

ATOM 1068 CB ARGA 151 -24.743 6.397-45.6971.0028.54 A

ATOM 1069 CG ARGA 151 -25.099 5.163-46.4501.0030.76 A

ATOM 1070 CD ARGA 151 -26.414 4.684-45.883 1.0034.21 A ATOM 1071 NE ARG A 151 -26.892 3.424-46.4481.00-36.93 A

ATOM 1072 CZ ARG A 151- -26:40-1 2.227-46.-1601.0037.57 A

ATOM 1073 T<H-1 ARGA.151 -26.913 1.148 -46.746 JL 0038.44 A

ATOM- 1074 NΗ2-ARGA151 -25.420.2J1-2 -45.2821.0037.66 A

ATOM 1075 C AΕXΪA151 -23.170 7.220-44.011 L:Q0:26.81 A ATOM 1076 O ARG-A 151- -22.711 7.931-44.898 T.OO 27.38 A

ATOM 10-77 N- -SER A 152 -22.872 7:375-42.7341.00-25.68 A

ATOM 1-078 CA SERA-152 -21.942 8,399-42.298 l-.00=24.56 A

ATOM 1079 CB SERA 152 -22.453 9.101-41.058 1.0023.94 A

ATOM 1080 OG SERA 152 -21.331 9.498-40.3061.0022.27 A ATOM 1081 C SERA 152 -20.673 7.671-41.9541.0024.24 A

ATOM 1082 O SERA 152 -20.648 6.903-40.991 1.0025.05 A

ATOM 1083 N TYRA 153 -19.627 7.895-42.737 1.0022.43 A

ATOM 1084 CA TYRA 153 -18.373 7.194-42.499 1.0021.69 A

ATOM 1085 CB TYRA 153 -17.269 7.722-43.4181.0019.99 A ^

ATOM 1086 CG TYRA 153 -15.958 6.961 -43.350 1.00 19.94 A

ATOM 1087 CDl TYRA 153 -15.715 5.855 -44.162 1.00 18.86 A

ATOM 1088 CEl TYR A 153 -14.496 5.193 -44.116 1.00 18.65 A

ATOM 1089 CD2 TYRA 153 -14.948 7.370 -42.489 1.00 20.83 A ATOM 1090 CE2 TYRA 153 -13.735 6r708 -42.438 1.00 19.36 A

ATOM 1091 CZ TYRA 153 -13.515 5.631 -43.250 1. GO 18.44 A

ATOM 1092 OH TYRA 153 -12.295 5.009 -43.192 1.0020.87 A

ATOM 1093 C TYRA 153 -17.936 7.315 -41.052 1.0021.70 A

ATOM 1094 O TYRA 153 -17.727 6.308 -40,387 1,0021796 A ATOM 1095 N ALA A 154 -17.803 8.543 -40.565 1.0022.27 A

ATOM 1096 CA ALA A 154 -17.377 ^"8.-765 -39.189^~1.00 23.22 A

ATOM 1097 CB ALA A 154 -17.384 10.253 -38.877 1.0023.11 A

ATOM 1098 C ALA A 154 -18.271 8.007 -38.200 1.00 23.93 A

ATOM 1099 O ALAA 154 -17.781 7.316 -37JL05 -1.0022.48 A ATOM 1100 N META L55 -19.583 8.119 -38.371 1.0O^"24:92 A

ATOM 1101 CA META 155 -20.488 7.432 -37.463 1.0025.65 A

ATOM 1102 CB META 155 -21.934 7.729 -37.823 1.0027.41 A

ATOM 1103 CG META 155 -22.883 7.324 -36.734 1.0028.27 A

ATOM 1104 SD MET A 155 -24.323 8.359 -36.792 1.00 33.58 A ATOM 1105 CE MET A 155 -25.632 7. L39 -37.002 1.00 31.32 A

ATOM 1106 C MET A 155 -20.255 519-26 -37.452 1.00 24.3Θ- A

ATOM 1107 O ^'MET A 155 -20.147 5.315-36.393 1.00 2433 A

ATOM M08 N LEUAJL56 -2-0,186 5.31*~38.626JL 0024.1-0 A

ATOM 11Θ9K:A LEU A 156 -19.93-7 3.883 J8.689 1.0024.32 A ATOM 1110 CB LEUA 1:56 -19,887 3423^"-4O.149 1-0024.56- A

A-TQM- 1111 CG LEUA 156 -2 ITl 62 3.725 -40.932 1.0025.43 A

ATOM 1112 CDl LEU A-156 -20.880 3.649-42.411 1.0025.43 A

ATOM 1113 CD2 LEU AJ56 -22.258 2.750 -40:521 1.00 25.11 A

ATOM 1114 C LEU A 156 -L8.598- 3.594 -37.995 1.0023.09 A- ATOM 1115 O LEUA 156 -18.470 2.632 -37.243 1.0021.87 A

ATOM 1116 N LEUA 157 -17.611 4.449 -38.235 1.0021.87 A

ATOM 1117 CA LEU A 157 -16.295 4.274 -37.645 1.0020.18 A

ATOM 1118 CB LEUA 157 -15.350 5.369 -38.128 1.00 17.05 A

ATOM 1119 CG LEU A 157 -13.965 5.307 -37.502 1.00 15.05 A ^

ATOM 1120 CDl LEUA 157 -13.372 3.936-37.771 1.0014.95 A

ATOM 1121 CD2LEUA157 -13.085 6.412-38.0421.0012.32 A

ATOM 1122 C LEUA 157 -16.349 4.292-36.128 1.0022.27 A

ATOM 1123 O LEUA 157 -15J642 3.542-35.4641.0023.67 A ATOM 1124 N PHE A 158 -17.185 5.153 -35.569 LOO 23.33 A-

ATOM 1125 CA PHEA 158 -17.280 5.236-34.1241.Θ023.28- A

ATOM 1126 CB PHEA 158 -18.139 6.435-33.708 1.0025.38 A

ATOM 1127 CG PHEA 158 -18.106 6.716-32.2341.0025.39 A

ATOM 1128 CDl PHE A 158 -16.954 7.218-31.6471.0024.91 A ATOM 1129 CD2 PHE A 158 -19.214 6.450 -3 L433 1.0025.76- A

ATOM 1130 CEl PHEA 158 -16τ897 7.452-30.285 1.00-27.20 A

ATOM 1131 CE2JPHEA158 -19.172 6.681 -30.056 LDO 26.45 A

ATOM 1132 CZ PHEA 158 -18.011 7.183-29.4801.0026.66 A

ATOM 1133 C PHEA 15S -17.873 3.956-33.5491.0022.38 A ATOM 1134 O PHE A 1-58 -17.443 3,480-32.5001.0023.71 A

ATOM 1135 N ALAA159 .18.860 3.393-34.230 1.0019.5-8 A

ATOM 1136 CA ALAA 159 -19.469 2.179-33.7271.0018.41 A

ATOM 1137 CB ALA A 159 -20.840 1.993-34.3481.0018.37 A

ATOM 1138 C ALA A 159 -18.594 0.958-33.9971.0017.41 A ATOM 1139 O ALAA 159 -18.556 0.021-33.2121.0018.35 A

ATOM 1140 N TRPA 160 -171883 0.966-35.111 1.0015.88 A

ATOM 1141 CA-TRPAlW- -17.049 -0.173. -35^45 LOJO 12.85 A

ATOM 1142 CB TRPA-160 -16,479 -0.031 -36.862.1.Θ09,75 A

ATOM^ 1743 GG T-RPA 160 -15.782 -1.283-37328 1.004.56 rA- ATOM- 1144002-TRPAIGO -14.423 -1.661-37.070-1.00 1.15 A

ATOM 1145 CE2TRPA16Θ- -14:253 -2.96S-37.5721.00 LOO A

ATOM 1146 CE3TKP^~A-160 -13339 -1.026 -36458" 1.00 ^"L-OO A

ATOM 1147 CDl TRPA 160 -16.355 -2.337 -37.96J61.00- 4.30 A

ATOM 1148 NEl-TRPA 160 -15.448 -3.355 -38.112 1.003.11 A ATOM 1149 CZ2 TRP A 160 -13.047 -3.648-37.482 1.00 1.00 A

ATOM 1150 CZ3TRPA160 -12.142 -1.703-36.3671.00 1.90 A

ATOM 1151 CH2 TRP A 160 -12.003 -3.006-36.8761.001.00 A

ATOM 1152 C TRPA 160 -15.906 -0.267-34.4461.0012.98 A

ATOM 1153 O TRPA 160 -15.565 -1.356-33.961 1.0011.94 A ^₅

ATOM 1154 N GLUA 161 -15.302 0.884-34.1671.0012.93 A

ATOM 1155 CA GLUA 161 -14.185 0.978-33.218 1.0014.44 A

ATOM 1156 CB GLUA 161 -13.534 2.350-33.333 1.0013.89 A

ATOM 1157 CG GLUA 161 -12.256 2.534 -32.5701.0012J6 A ATOM 1158 CD-GLUA 161 -11.753 3.964-32.691 1.0016.17 A

ATOM 1159 OEl GLUA 161 -10.583 4.215-32.3301.0015.57 A

ATOM 1160 OE2 GLUA 161 -12.536 4.845-33.145 1.0018.99 A

ATOM 1161 C GLUA 161 -14.722 0.788-31.793 1.0015.91 A

ATOM 1162 O GLUA 161 -14.159 0.038 -30.992 T.OO 16.26 A ATOM 1163 N GLYA 162 -15.821 1.474-31.494 1.0015.58 A

ATOM 11-64 CA GLYA 162 -16.426 1.352-10.1941.0016.39 A

ATOM- 1165 C GLYA 162 -16.646 -0.095 -.29.813 100 T7.G6 A

ATOM 11660 GLYA 162 -16.148 -0.567-28.778 1.0017.28 A

ATOM 1167 N TRP A 163 -17.384 -0.807-30.6541.0016.93 A ATOM 1168 CA TRPA 163 -17.682 -2.204-30.3821.0019.23 A

ATOM 1169 CB TRPA 163 -18.658 -2.762-31.4201.001.9.12 A

ATOM 1170 CG TRPA 163 -18.864 -4.208-31.2361.0020.56 A

ATOM 1171 CD2 TRP A 163 -19.522 -4.834-30.138 1.0023.18 A

ATOM 1172 CE2 TRPA 163 -19.405 -6,233^"-30.32O 1.0024.32 A -ATOM 1173 CE3 TRP A 163 -20.198 -4.351-29.013 1.0021.92 A

ATOM 1174 CDl TJRPA 163 -18.390 -5.208-32.020 1.0022.19 A

ATOM 1175- NEl TRPA 163 -18.707 -6.436-31.479 ItOO 24.10- A

ATOM 1176 CZ2 TRP A 163 -19.941 -7.152-29.420-1.0024,81 A

ATΘM 1177 CZ3-TRPA1-63 -20,729^" -5τ257 -28.1261.00_24.35 A- ATOM 1178 CH2JTRP A463 ~20.600--6.648 -28332" 1.0025.25 A

ATOM- 1179 C TRPA 163 -1:6.466 -3.129 -30.299 LGS 1&5Θ A

ATOM- 1180 O- TRP A 163 -16.408 -4.038 -29r4<551.ΘIT21.07 A

ATOM 1181 N HIS A 164 -15.485 -2.894-311501.0018.68 A

ATOM 1182 CA HIS A 1-64 -14.318 -3.757-311691.00 J 8.91 A ATOM 1183 CB HISA 164. -13.554 -3.590-32.4891.0018.22 A

ATOM 1184 CG HISA 164 -14.174 -4.326-33.6341.0015.27 A

ATOM 1185 CD2 HIS A 164 -13.819 -5.485-34.23810014.32 A

ATOM 1186 NDl HIS A 164 -15.355 -3.932-34.223 1.0013.00 A

ATOM 1187 CEl HISA 164 -15.704 -4.820-35.138 1.0011.78 A _. , _,

416

ATOM 1188 NE2HISA164 -14.788 -5.772-35.166 1.0011.00 A

ATOM 1189 C HISA 164 -13.374 -3.581-30.002 1.0019.14 A

ATOM 1190 O HIS A 164 -12.664 -4.520-29.623 1.0018.85 A

ATOM 1191 N ASNA 165 -13.319 -2.376-29.459 1.0019.19 A ATOM 1192 CA ASNA 165 -12.470 -2.164-28.3041.0020Λ4- A

ATOM 1193 CB ASNA165 -12.149 -0.684-28.116 1.0022.15 A

ATOM 1194 CG ASNA 165 -11.188 -0.161-29.1571.0023.49 A

ATOM 1195 ODl ASN A 165 -10.303 -0.882-29.6281.0023.72 A

ATOM 1196 ND2 ASNA 165 -11.339 1.111-29.5051.0024.40 A ATOM 1197 C ASNA 165 -13.253 -2.674-27.1041.0020.19 A

ATOM 1198 O ASNA 165 -12.779 -3.514-26.3401.0019.38 A

ATOM 1199 N ALAA 166 -14.480 -2.1-80-26.988 1.0020.55 A

ATOM 1200 CA ALAA 166 -15.376 -2.537-25.8981.0020.32 A

ATOM 1201 CB ALA-A 166 -16.729 -1:886 -26.123 1.0020.37 A ATOM 1202 C ALA A 166 -15.555 -4.027-25.6541:0019-46 A

ATOM 1203 O ALA A 166 -15.577 -4.464-24.5141.0020.77 A

ATOM 1204 N ALA A 167 -15.670 -4.815 -26.710 l.OQ 19.30 A

ATOM 1205 CA ALA A 167^" -15.879 -6.237-26.5341.0019.08 A

ATOM 1206 CB ALAA 167 -16.804 -6.743 -27:6281.0021.14 A ATOM 1207 C ALAA 167 -14.601 -7.05J -26.5291.0019.33 A

ATOM 1208 O ATAA 167 -14.469 -8.015 -25.7881.0-021.26 A

ATOM- 1209- N GLYA 168 -13.650 -6:663-27.3541.0019.00 A-

ATOM 1210 CA GLYA 168 -12.440 -7.443-27.450 kθO 18.94 A

ATOM^" 1211 C GLYA-1-68; -11.400 -7.347-26.369 1.0018,02 A ATOM 1212^~α GLYAJ68 -11.063 -8.353 -J± 753-1.001*72 -A

ATOM 1213 N ILE A 169 -10,876-6:147 -26.T62 1.0016.73 A

ATOM 12-14 CA JLE A 169 -9.840 -5.936-25.175- 1.0015.94 A

ATOM 1215 CB ILE A 169 -9.666 -4.434-24.932 1.0016.26 A

ATOM 1216 CG2 ELE A 169 -8.733 -4.190-23.7361.001-8.24 A ATOM 1217 CGl ILEA 169 -9.110 -3.789 -26.2Θ2 LOO 13.73 A

ATOM 1218 CDl ILE A 169 -9.090 -2.272-26.1741.0013.87 A

ATOM 1219 C ILEA 169 -10.000 -6.680-23.8371.0014.63 A

ATOM 1220 O ILE A 169 -9.080 -7.373-23.398 1.0013.27 A

ATOM 1221 N PROA 170 -11.168 -6.569-23.185 1.0014.58 A ATOM 1222 CD PRO A 170 -12.394 -5.846 -23.5681.0014.74 A

ATOM 1223 CA PROA 170 -11.340 -7.266-21.9001.0014.12 A

ATOM 1224 CB PROA 170 -12.660 -6.716-21.385 1.0013.73 A

ATOM 1225 CG PROA 170 -13.441 -6.467-22.6571.0014.71 A

5 ATOM 1226 C PROA 170 -11.364 -8.773 -22J009 1.0013.26 A

ATOM 1227 O PRO A 170 -10.970 -9.488-21.1171.0014.14 A

ATOM 1228 N LEUA 171 -11.830 -9.228-23.151 1.0013.65 A

ATOM 1229 CA LEUA 171 -11.989-10.629-23.491 1.0013.79 A

ATOM 1230 CB LEUA 171 -12.832 -10.636 -24.7471.0014.97 A 0 ATOM 1231 CG LEUA 17L -13.921-11.681-24.915 1.0016.26 A

ATOM 1232 CDl LEUA 171 -14.263-12.317-23.5661.0018.92 A

ATΘM 1233 CD2LEUA171 -15.13-2-10.978-25.533 1.00 L4.84 A-

ATOM 1234 C LEUA 171 -10.719-11.465-23.721 1.0012.87 A

ATOM 1235 O LEUA 171 -10.672 -12.670 -23.50S 1.0013.73 A 5 ATOM 1236 N LYS A 172 -9.686-10.796-24.1781.0011.56 A

ATOM 1237 CA LYS A 172 -8.448-11.451-24.5141.0011.50 A

ATOM 1238 CB LYS A 172 -7.439 -10.416 -24.983 1.0012.78 A

ATOM 1239 CG LYS A 172 -6.252-11.01-7-25.6761.0014.38 A

ATOM 1240 CD LYS A 172 -5.413 -9.923 -26.283 1.0016.72 A 0 ATOM 1241 CE LYS A 172. -4.098-10.453-26.819 1.0019.00 A

ATOM 1242 NZ LYS A 172 -3.200 -9.344 -27.291 1.0020.51 A

ATOM 1243- C LYS A 172 -7.814-12.342-23.476 1.0012.52. A

ATOM- 1244 O LYS A_172 -7.620 -13.533 -23.728 1.0012.02 A

ATOM 1245 N PROA 173 -7:4.77 -11.792-2X231- 170013.89 A 5- -ATOM 1246 CD PRO A 173 -7.828 -1U463 -21.752 LJOO 13.93 A

ATOM 1247 CA PRO A.173 -6.852 -12.620 -21-250 LQO 11.31 A

ATOM 1248= CB PROA 173 -6.724 -1L651-20.0781.0012.17 A

ATOM 1249 CG PRO A 173 -7.882-10.728-20.271 1.0011.50 A

ATOM 1250 C PROA 173 -7.660-13.876-20.910 IJOO 10.08 A O ATOM 1251 O PROA 173 -7.104-14.963-20.760 1.008.90 A

ATOM 1252 N LEUA 174 -8.975-13.731-20.815 1.009.26 A

ATOM 1253 CA LEUA 174 -9.791-14.892-20.516 1.0010.17 A

ATOM 1254 CB LEUA 174 -11.287-14.574-20.4091.008.28 A

ATOM 1255 CG LEUA 174 -12.009-13.433-19.673 1.007.40 A ATOM 1256 CDl LEUA 174 -13.101-14.068-18.831 1.002.59 A

ATOM 1257 CD2 LEU A 174 -11.103-12.627-18.7831.001.00 A

ATOM 1258 C LEUA 174 -9.685-15.911-21.6261.0012.40 A

ATOM 12590 LEUA 174 -9.611-17.117-21.3591.0012.37 A AFOM 1260 N TYRA 175 -9.729-15.438-22.8771.0013.85 A

ATOM 12CT CA TYRA 175 -9.695-1-6.366-24.0121.0011.87 A

ATOM 1262 CB TYRA 175 -9.802-15.655-25.3841.0013.99 A

ATOM 1263 CG TYRA 175 -10.214-16.611-26.5091.0014.52 A

ATOM 1264 CDlTYRA 175 -11.540-17.049-26.6141.0015.07 A ATOM 1265 CEl TYRA 175 -11.921-18.033-27.5371.0016.19 A

ATOM 1266 CD2 T-YR A175 -9.264 -17.179^~-27.3741.0014.81 A

-ATOM 1267 CE2 TYRA 175 -9.635-18.175-28.3061.0016.26 A-

ATOM 1268 CZ TYRA 175 -10.975-18.598-28.3741.0016.48 A

ATOM 1269 OH TYRA 175 -11.391-19.592-29.2451.0014.40 A ATOM 1270 C TYRA 175 -8.448-17.218-24.0071.0010.28 A

ATOM 1271 O TYRA 175 -8.519-18.420-24.1921.0010.02 A

ATOM 1272 N GLUA 176 -7.307-16.595-23.7921.009.52 A

ATOM 1273 CA GLU A 176 -6.054-17.328-23.7771.0013.00 A

ATOM 1274 CB GLUA 176 -4.920-16.401-23.4021.0011.20 A ATOM 1275 CG GLU A 176 -4.895 -15J3O -24.197 LOO 12.19 A

ATOM 1276-CD GLU A 176 -3.785 -14JU5 -23.735 1.0013.44 A

ATOM 1277 OEl GLUA 176 -3.066 -14.622 -22.8B LOO 14.86 A

ATGM 1278 OE2 GLUA L76 -3.610-13.098-24.271 1.0014.79 A

ATOM 1279 C GLU A-176 -6.077 -18.4*6 -22.7651.00-16.F7. A ATOM- 128Θ O GLUA 176 -5.482-19.506-22.9691.0016.43 A

ATOM 1281 N ASP A 177 -6.738 -18rl60 -21.643 1.0020.64 Jt

ATOM _1282 CA ASP A 177 -6.843-19:115-20.551 1.00-22.10 A

ATOM 1283 CB ASP A 177 -7.159 -18.383 -19.247 LOO 23.86 A

ATOM 1284 CG ASP A 177 -5.903-17.960-18.5161.0022.96 A ATOM 1285 ODl ASPA 177 -4.821-18.502-18.8671.0023.41 A

ATOM 1286 OD2 ASP A 177 -6.009-17.106-17.6071.0021.25 A

ATOM 1287 C ASPA 177 -7.839-20.222-20.8121.0022.70 A

ATOM 1288 O ASPA 177 -7.631-21.381-20.451 1.0024.27 A

ATOM 1289 N PHE A 178 -8.914-19.863-21.4791.0022.44 A ^

ATOM 1290 CA PHEA 178 -9.904-20.849-21.8121.0022.21 A

ATOM 1291 CB PHEA 178 -11.106 -20.175 -22.4201.Θ022.97 A

ATOM 1292 CG PHEA 178 -11.777-21.026-23.425 1.0025.29 A

ATOM 1293 CDl PHE A 178 -12.948-21.694 -23.0941.0026.68 A ATOM 1294- CD2 PHE A- 178- -11.200-21.216-24.6981.0025.77 A

ATOM 1295 CEl PHEA 1-78 -13.562-22.542-23:9971.0025.42 A

ATOM 1296 CE2 PHE A 178 -11.788-22.066-25.631 1.0023.59 A

ATOM 1297 CZ PHEA 178 -12.983-22.735-25.2801.0024.90 A

ATOM 1298 C PHE A 17* -9.348-21.835 -22.8401-.0Θ 21.75 A ATOM 1299 O PHE A 178 -9.768-22.977-22.9561.0023.13 A

ATOM 1300 N- THRA 179 -8.413-21.355-23.6261.0021.75 A

ATOM 1301 CA THR-A- 1.79 -7.857 -22.167 -24.675 LOΘ 22.49 A

ATOM 1302 CB THRA 179 -7.118-21.291-25.721 1.0021.36 A

ATOM 1303 OGl THRA 179 --8.076-20.568-26.5091.0021.11 A ATOM 1304 CG2 THRA 179 -6.258-22.147-26,615 1.0020.77 A .

ATOM 1305 C THRA 179 -6.922 -23.160 -24Λ61 1.0023.81 A

ATOM 1306 O THRA 179 -6.954 -24.339 -24.3871.0025.76 A

ATOM 1307 N ALAA 180 -6.096-22.698-23.141 1.0025.25 A

ATOM 1308 CA ALAA 180 -5.167 -23.61-5 -22J041.0026.11 A ATOM 1309 CB ALA A 180 -4.362-22.900-21.4491.0024.86 A

ATOM 1310 C ALA-AlSO -5.929-24.779-21.8791.0027.30 A

ATOM 1311 O ALAA 180 -5756Q -25.945 -22T055 1.0026.99 A

ATOM 1312 N LEUA 181 -7.004^" -24.457 -21.166 l_ΘQ27τ81 A

ATOM^" 1313 CA LEU- A- 181 -7.796-25.485-20.511 1.0028.96- A: ATOM 1314 CB LEUA rSl- -O18 -24.842 -19:563 1.0028.50 A

ATOM 1315 CG EEUAlXl- -8.192-24.370-18.2351.0027:96 A

ATOM 1316 CDl LEUA 181- -9J240--23-.670 -17.4001.0028.14 A

ATOM- L317 CD2LEUA181 -7.595 -25.553 -17.472 k0025.65 A

ATOM 1318 C LEUA 181 -8.486-26.423-21.492-1.0030.05 A ATOM 1319 O LEUA 181 -8.299-27.652-21.4261.0029.72 A

ATOM 1320 N SERA 182 -9.265-25.842-22.4081.0031.02 A

ATOM 1321 CA SERA 182 -9.987-26.615-23.423 1.0029.91 A

ATOM 1322 CB SERA 182 -10.536-25.701-24.5081.0029.45 A

ATOM 1323 OG SERA 182 -11.540-26.385-25.2301.0032.81 A ...

ATOM 1324 C SERA 182 -9.042-27.634-24.045 1.0028.27 A

ATOM 13250 SERA 182 -9.379-28.801-24.225 1.0028.32 A

ATOM 1326 N ASNA 183 -7.848-27.180-24.371 1.0026.59 A

ATOM 1327 CA ASNA L83 -6.855-28.064-24.9301.0028.72 A

5 ATOM 1328 CB ASNA 183 -5_562 -27294 -25.146 k0029.24 A

ATOM 1329 CG ASNA 183 -5.275-27.033-26.6071.0029.72 -A

ATOM 1330 ODl ASNA 183 -6.185-26.749-27.394 1.0030.05 A

ATOM 1331 ND2 ASN A 183 -3.997-27.096-26.976 1.0027.72 A

ATOM 1332 C ASNA 183 -6.588^" -29.215 -23.972 1.0030.11 A 0 ATOM 1333 O ASNA 183 -6.846-30.391-24.255 1.003L24 A

ATOM 1334 N GLUA 184 -6.064 -28.847 -22.815^{^} 1.0030.78 A

ATOM 1335 CA GLUA 134 -5.720-29.819-21.7991.0029.64 A

ATOM 1336 CB GLUA 184 -5.543-29.146-20.459 1.0030.56 A

ATOM 1337 CG GLU A 184 -5.096 -30.116 -19.403 1.0032.92 A 5 ATOM 1338^" CD GLU A 184 -5.059-29.482-18.0471.0034.26 A

ATOM 1339 OEl GLUA 184 -6.034-28.779-17.7021.0034.45 A

ATOM 1340 OE2 GLUA 184 -4.057 -29.6S>6 -17.3341.0035.S5 A

ATOM 1341 C GLU A 184 -6.748-30.905-21.6461.0028.64 A

ATOM 1342 O GLUA 184 -6.418-32.075-21.4921.0028.89 A 0 ATOM 1343 N ALAA 185 -8.003-30.502-21.6921.0026.95 A

ATOM 1344 CA ALA A 185 -9.091 -31.436 -21.553- LOO 26.57 A

ATOM 1J45 CB ALAA 183 -10.37Q -3<0.664 -21.542 LOO 2S67 A

AT0M 1346 C ALAA 1-85 -9.095 -32.508-22.658 hOO-26.76 A

ATOM 1347 O- ALAA 185 -9.024-33.702-22.3-78- 1.0027:85 A T ATOM B48^~N TYRA 186 -9.175-32.095 -23.917 lTOO 26,DS A

ATOM 1349-CA TYRA 186 -9.175 -33.077^~25τ015 J.0024.31 A

AXOM 1350^~CB TYR A 186 -9.717-32.476 -26286 ITOO 16J3. A

ATOM^" 1351 CG TYRA 186 -11.100 -32.019 -26.1571.008:67 A

ATOM 1352 CDl TYRA 186 -11.388-30.663-26.0861.006.93 A 0 ATOM 1353 CEl TYRA 186 -12.682-30.230-25.9691.004.18 A

ATOM 1354 CD2 TYR A 186 -12.133-32.941-26.1041.006.31 A

ATOM 1355 CE2 TYRA 186 -13.437-32.540 -25.985 1 JDO 2.90 A

ATOM 1356 CZ TYRA 186 -13.712-31.187-25.925 1.002.67 A

ATOM 1357 OH TYRA 186 -15.027-30.798-25.8701.00 1.61 A ATOM 1358 C TYRA 186 -7.867-33.690-25.419 1.0027.00 A

ATOM 1359 O TYRA 186 -7.832-34.358-26.4321.0027.34 A

ATOM 1360 N LYS A 187 -6.803-33.439-24.676 1.0029.61 A

ATOM 1361 CA LYSA 187 -5.475 -33.972 -25.0251.0033.11 A

ATOM 1362 CB LYS A 187 .4.443-33.135-24,291 1.0031.97 A

ATOM 1363 CG LYS A 187 -3.261-32.700-25.0511.0032.63 A

ATOM 1364 CD LYS A 187 -2.007-33.401-24.5971.0034.29 A

ATOM 1365 CE LYSA 187 -0.792-32.715-25.2181.0035.41 A

ATOM 1366 NZ LYS A 187 0..49T -33.173 -24.5901.0037.39 A

ATOM 1367 C LYS A 187 -5.430-35.309-24.3891.0035.79 A

ATOM 1368 O LYS A 187 -4.469-36.011-24.351 1.0036.75 A

ATOM 1369 N ALAA 188 -6.597-35.559-23.902 LOO 38.16 A

ATOM 1370 CA ALAA 188 -6.891-36.642-23.0171.0039.96 A

ATOM 1371 CB ALAA 188 -7.797-36.063-22.0161.0040.43 A

ATOM 1372 C ALA A 188 -7.6G8- -37.788 -23.6191.0041.20 A

ATOM 13.73 O ALAA 188 -7.427-38.979-23.3681.0042.24 A

ATOM 1374 _N ASPA 189 -8,458-37.214-24.365 1.0041.64 A

ATOM 1375 CA ASPA 189 -9.435-37.880-25.056 1.0041.67 A

ATOM- 1376 CB ASP A 1.89 -10.597 -36.858 -25.265 1.0041.75 A

ATOM 1377 CG ASP A 189 -11.475-36.792-24.163 1.0042.84 A

ATOM 137-8 ODl ASPA 185» -11.372-37.807-23.5241.0042.68 A

ATOM 1379 OD2ASPA189 -12.253^~-35.798 -23.985 LOO 42.17 A

ATOM 1380-C ASPAJ89 -3.797 -38.148 -26A05 LOO 41.46 A

ATOM 1381 O ASPA- 139 -9.429 -38. L89L-27.432 LOO 4331 A

ATOM 13β2 N GLY ΛΛ 90 -7.484^38.133-26.462 1.00-39.75 A

ATOM 1383 CA GLY A -190 -6.842 -38_^440-27.764 1.Θ939.30 A

ATOM 1384-C GLYA 190 -07403 -3773^~64 -28.781 l-.ΘO38τ81- A

ATOM 1385 O GLYA 190 -5:280 -37.411- -29.271 1.003S.94 A

ATOM 1386 N PHEA 191 -7.256 -36J58 -29.0921.0037.00 A

ATOM 1387 CA PHEA 191 -6.871 -35J340 -30.011 1.0036.09^" A

ATOM 1388 CB PHEA 191 -8.047-34.402-30.1181.0037.24 A

ATOM 1389 CG PHEA 191 -9.335-35.135-30.1721.0039.74 A

ATOM 1390 CDl PHE A 191 -10.371-34.818-29.3161.0040.83 A

ATOM 1391 CD2 PHE A 191 -9.494-36.190-31.0721.0040.45 A ^

ATOM 1392 CEl PHEA 191 -11.553-35.544-29.351 1.0040.18 A

ATOM 1393 CE2PHEA191 -10.677-36.927-31.1241.0041.24 A

ATOM 1394 CZ PHEAlSl -11.715-36.599-30.262 1.0040.46 A

ATOM 1395 C PHEA 191 -5.594-34.598-29.5941.0035.42 A ATOM 1-3960 PHEA 191 -5.015-34.902-28.563 1.0036.10 A

ATOM 1397 N THRA 192 -5.151 -33.639 -30.408 1.0034.84 A

ATOM 1398 CA THRA 192 -3.931-32.872-30.123 1.0033.63 A

ATOM 1399 CB THRA 192 -3.182-32.437-31.4061.0035.57 A

ATOM 1400 OGl THRA 192 -2.651 -33.582 -32.0821.0037.9S- A ATOM 1401 CG2 THR A 192 -2.039-31.466-31.056 LOO 36.46 A

ATOM 1402 C THRA 192 -4.327-31.600-29.433 1.0032.14 A

ATOM 1403 O IHR A 192 -3.665 -31.154-28.4991. OQ 32.93 A

ATOM 1404 N ASP A 193 -5.400-31.007-29.9421.0029.05 A

ATOM 1405 CA ASP A 193 -5.943-29.771-29.4101.0028.30 A ATOM 1406 CB ASP A 193 -5.284 -28.569 -30.068 1.0030.53 A

ATOM 1407 CG ASP A 193 -5.22S -28.689 -31.5841.0033.24 A

ATOM 1408 ODl ASP A 193 -6.299-28.587-32.231 1.0033.41 A

ATOM 1409 OD2 ASP A 193 -4.109-28.893-32.1291.0031.70 A

ATOM 1410 C ASP A 193 -7.419-29-775-29.7161.0027.22 A ATOM 1411 O ASP A 193 -7.890-30.665-30.415 1.0025.92 A

ATOM 1412 N THRA 194 -S.157-287794 -29.2041.0026.47 A

ATOM 1413 CA IΗR A 194- -9.593-28.769-29.445 1.0026.18 A

ATOM 1414 CB THRA 194 -10.250 -27.627 -28.688" l.aG_-24.32 A

ATOM 1415 ΘG1 THRA 194 -9.637 -27.529 -27.404 l:©022.31 A ATOM 1416 CG2 THR A 194 -11.744 -27.895 -28:508 l.βθ-25-50 A

ATQM 14.17 C THRA 194 -9^886 -28.635-30.9241.0026.18 A-

ATΘM L418 O THRA 194 -10.959-29.010-31.4001.00-27706 A

ATOM 1419 N GLYA 195 -8.913-28.107-31.6521.0026.72 A

ATOM 1420 CA GLY A 195 -9.084-27.937-33.081 1.0026.88 A ATOM 1421 C GLYA 195 -9.355-29.273-33.735 1.0025.92 A

ATOM 14220 GLYA 195 -10.362-29.460-34.4171.0025.20 A

ATOM 1423 N ALA A 196 -8.444-30.211-33.5171.0025.32 A

ATOM 1424 CA ALA A 196 -8.576-31.541-34.0821.0025.47 A

ATOM 1425 CB ALAA 196 -7.384-32.402-33.671 1.0023.95 A ^

ATOM 1426 C ALA A 196 -9.882-32.195-33.641 1.0026.30 A

ATOM 14270 ALA A 196 -10.535-32.867-34.4301.0026.96 A

ATOM 1428 N TYR A 197 -10.266-31.994-32.3841.0027.58 A

ATOM 1429. CA TYR A 197 -11.496-32.588-31.878 1.0028.53 A ATOM 1430 CB TYRA 197 -11.677-32.294-30.375 LOO 26.60 A

ATOM 1431 CG TYRA 197 -13.0.62-32.661-29.853 1.0022.86 A

ATOM 1432 CDl TYRA 197 -13.523-33.970-29.9001.0020.50 A

ATOM 1433 CEl TYRA 197 -14.791-34.307-29.5121.0020.23 A

ATOM 1434 CD2 TYR A 197 -13.932-31.690-29.3871.0021.31 A ATOM 1435. CE2 TYRA 197 -15.220 -32.018 -28.99S 1.0020.03 A

ATOM 1436 CZ TYRA 197 -15.640 -33.326 -29.0661.0019.88 A

ATOM 1437 OH TYRA 197 -16.927 -33.649 -28.719- 1.0020.97 A

ATOM 1438 C TYRA 197 -12.681-32.031-32.645 1.0029.97 A

ATOM 1439 O TYRA 197 43,619-32.750-32.9871.0030.48 A- ATOM 1440 N TRPA 198 -12.636-30,734-32.8971.003 L97 A

ATOM 1441 CA TRP A 198 -13.705-30.072-33.6171.0034.86 A

ATOM 1442 CB TRPA 198 -13.458-28.574-33.642 1.0037.29 A

ATOM 1443 CG TRPA 198 -13.793-27.878-32.3971.0039.31 A

ATOM 1444 CD2 TRP A 198 -13.793-26.465-32.1901.0040.91 A ATOM 1445 CE2 TRP A 198 -14.174-26.242-30.8521.0041.28 A

,ATOM 1446 CE3 TRP A 198 -13.508- -25.361 -33.007 LOQ 41.29 A

ATOM 1447 CDl TRP-A 198 -14.1J60 -28:442-31.2201.0039.85 A

ATOM 144*- NEl TRP A 198 -14,392-27.468-30.2821.0040.92 A

ATOM 1449- GZ2 TRP A 198 -142-78 -24:958 -30.306 1.00-42.20 A ATOM 1450 CZ3 TRP A 198 -13:610 -24.084 -32.4671.D&42.32 A

ATOM- 1451 CH2 TRP-A 198 -13.992--23.895 -31.1271.00-43.03 A

ATOM 1452 C TRPA 198 -B.8L6 -30:569-35.053 LOG 35.75 A

ATOM 14530 TRPA 198 -14.906-30.715-35^841.0035.48 A

ATOM 1454 N ARGA 199 -12.683-30.830-35.691 1.0036.46- A ATOM 1455 CA ARGA 199 -12.789-31.277-37.0561.0037.46 A

ATOM 1456 CB ARGA 199 -11.850-30.407-37.9721.0036.58 A

ATOM 1457 CG ARG A 199 -10.390-30.741-38.1161.0035.12 A

ATOM 1458 CD ARGA 199 -9.517-29.511-37.9671.0033.89 A

ATOM 1459 NE ARGA 199 -8.209-30.021-37.6051.0035.13 A _m

ATOM 1460 CZ ARG A 199 -7.236-29.354-37.002 1.0037.14 A

ATOM 1461 NHl ARG A 199 -6.095 -29.987 -36.735 1.0037.36 A

ATOM 1462 NH2 ARG A 199 -7.391-28,081-36.681 1.0038.72 A

ATOM 1463 C ARGA 199 -12.732-32.820-37.258 1.0038.11 A ATOM 1464 O ARGA 199 -12.517-33.332-38.361 1.0037.98. A

ATOM 1465 N SERA200 -12.961-33.555-36.1641.0038.32 A

ATOM 1466 CA SER A 200 -13.020-35.023-36.2171.0039.86 A

ATOM 1467 CB SER A 200 -12.539-35.698-34.9041.0040.16 A

ATOM 1468 OG SER A 200 -B.417 -35.444 -33.8141.0041.39 A ATOM 1469 C SER A 200 -14.498-35.303-36.3991.0040.86 A

ATOM 1470 O SER A 200 -14.912-36,438-36.641 1.0041.13 A

ATOM 1471 N TRP A 201 -15.292-34.243-36.2701.0041.71- A

ATOM 1472 CA TRP A 201 -16.743-34.340-36.4071.0042.86 A

ATOM 1473 CB TRPA 201 -17.428-33.168-35.824 1.00-45.41 A ATOM 1474 CG TRP A 201 -17.273-33.054-34.446 1.0048.8.8 A

ATOM 1475 CD2 TRP A 201 -17.706-31.958-33.691 1.O050.38 A

ATOM 1476 CE2 TRP A 201 -17.432-32.246-32.33-71.0051.40 A

ATOM 1477 CE3 TRP A 201 - 18.313 -30.744 -34.0271 ,0051.49 A

ATOM 1478 CDl TRP A 201 -16.745-33.966-33.5771.005030 A ATOM 1479 NEl TRP A 2Dl -16.837 -33.483 -32.294 LOO 51.96 A

ATOM 1480 CZ2 TRP A 2QL -17.745 -31352 -31.312 LOO^'51,83 A

ATOM^" 1481 CZ3 TRP A 201 -18,623 -29.854 -33:0271.0052.8-U^" A

ATOM L4£2::CH2TRPA201 -18344-30.160-31.6741.0052-85 A

ATOM 1483 C TRPτAJZΘl. -17.313 -34τ435 -37.7841.00-43ΛΘ5Γ A - ATOM- 1484 O IRP A 201 -18.529 -34.412 -37.950 LOO 4434 A_

ATOM 1-485 N TYR-A -202 -16.45.Q -34.487 -3^.780- 1.00-42:86 A.

ATOM 1486 CA TYRA 202 -16.920 -34τ596 -40.142 l.OO-41.78 A

ATOM 1487- CB TYR A 202 -16.436-33.411-40.9761.0038.06 A

ATOM 1488 CG TYRA 202 -17.059-32.119-40.5371.0033.84 A ATOM 1489 CDl TYR A 202 -16.52Z-31.404 -39.4821.0032.12 A

ATOM 1490 CEl TYR A 202 -17.114-30.240-39.0441.0031.23 A

ATOM 1491 CD2TYRA202 -18.212 -3 L638 -41.1491.0031.21 A

ATOM 1492 CE2 TYRA 202 -18.815-30.478-40.720 1.0030.59 A

ATOM 1493 CZ TYR A 202 -18.263-29.780-39.6671.0030.81 A ^

ATOM 1494 OH TYR A 202 -18.866-28.621-39.2481.0031.65 A

ATOM 1495 C TYR A 202 -16.449-35.908-40.7061.0042.48 A

ATOM 14960 TYR A 202 -16.796-36.281-41.821 1.0042.53 A

ATOM 1497^"N ALAA203 -15.655-36.615-39.9101.0043.07 A ATOM 149S CA ALA A 203 -157163-37.924-40.3171.0043.84 A

ATOM 1499 CB ALAA-203 -16.265 -38.956 -40.1O8 1.0043.61 A

ATOM 1500 C ALA A 203 -14.719-37.913-41.7671.0043.89 A

ATOM 1501 O ALA A 203 -15.372-38.477-42.651 1.0045.64 A

ATOM 1502 N SERA20^~4 -13.631-37.221-42.0391.0042.33 A ATOM 1503 CA SERA^"204 -13.105-37.166-43.373 1.0040.12 A

ATOM 1504 CB SER A 204 -13.725^~-36.029 -44.165 1.0040.94- A

ATOM 1505 OG SER A 204 -L3.139\35:964 -45.4561.0041.48 A

ATOM 1506 C SER A 204 -11.648-36.925-43.1781.0038.61 A

ATOM 1507 O SER A 204 -11.242-35.864-42.7221.0038.63 A ATOM 150S N PRO A 205 -1O.827 -37.917 -43.4901.0037.41 A

ATOM 1509 CD PRO A 205- -11.056-39.233 -44.113 LOO 36.62 A

ATOM 1510 CA PRO A 205 -9.400-37.656-43.281 1.0037.78 A

ATOM 1511 CB PRO A 205 -8.771-39.015-43.6431.0036.29 A

ATOM 1512 CG PRO A 205- -9-702 -39.547 -44.6971.0037.24 A ATOM 1513 C PRO A 205 -8.845-36.520-44.144 LOO 37.99 A

ATOM 13.140 PRO A 205^" -7.766-36.027-43.941 LOO 38.12 A

ATOM 1515 IvT THR A 206 -9.746 -36.010 -44.941 LOO 38.55 A

ATOM 1516--CA THRA 206 -9.394.-35.210 -46.021 1.0038.30 A

ATOM= 1517 CB-THRA 206 -9.693-36.206-47^01 1.0038.15 A- ATOM 1518-OC4-THRA206 -87495-36.325-47:9901.0037.56 A ATOM- 1519- CG2 THR A 206 -10:940^" -.35.741- -47.9-51 LOO 37.06 A

ATOM 1520-C THRA 206 -10.136-33.797-45.9091.0038.05 A

ATOM 1521 O THR A 206 -9.990 -32^840 -46.6871.0038.98 A

ATOM 1522 N PHE A 207 -10.926-33.699-44.8521.0036.97 A ATOM 1523 CA PHE A 207 -11.738-32.526-44.5561.0036.68 A

ATOM 1524 CB PHE A 207 -12.087-32.507-43.0661.0032.53 A

ATOM 1525 CG PHE A 207 -13.022-31.402-42.6761.0027.90 A

ATOM 1526 CDl PHE A 207 -14.213-31.194-43.363 1.0027.40 A

ATOM 1527 CD2 PHE A 207 -12.750-30.615-41.5801.0026.46 A ^

ATOM 1528 CEl PHE A 207 -15.128-30.215-42.951 1.0025.33 A

ATOM 1529 CE2PHEA207 -13.660-29.636-41.1621.0026.09 A

ATOM 1530 CZ PHE A 207 -14.852-29.442-41.8541.0024.59 A

ATOM 1531 C PHEA207 -11.142-31.171-44.941 1.0038.65 A

5 ATOM 15320 PHE A 207 -11.683 -30:4^'48 -45.2841.004O.r8 A

ATOM 1533 N GLU A 208 -10:031 -3O:8L1 -44.3ΪΘ- 1.0⁽T 4035 A

ATOM 1534 CA GLU A 208 -9.393-29.521-44.5841.0041.72 A

ATOM 1535 CB GLU A 208 -8.109-29.377-43.7641.0042.43 A

ATOM 1536 CG GLU A 208 -8.354-29:021 -42.304 i:0044.40 A

10 ATOM 1537 CD GLU A 208 -7.066-28.755-41.5451.0045.43 A

ATOM 1538 OEl GLU A 208 -6.413 -27.728 -4T.8251.0046.31 A

ATOM 153.9 OE2 GLUA 208 .6.703 -29.578 -4O.6771.0046.86 .A

ATOM 1540 C GLU A 208 -9.091-29.255-46.062 1.0042.46 A

ATOM 1541 O GLU A 208 -9.372-28,175.-46.581 1.0042.81 A

15 ATOM 1542 N ASP A 209 -8.5-14 -3O.240 -46.7361.0042.6-1 A

ATOM 1543 CA ASP A 209 -8.196-30.103-48.1371.0042.13 A

ATOM 1544 CB ASP A 209 -7.425-31.332-48.6041.0042.33 A

ATOM 1545 CG ASP A 209 -6.051-31.420-47.9791.0042.28 A

ATOM 1546 ODl ASP A 209 -5.418 -30.349 -47.833 h0042.17 A

20 ATOM 1547 OD2 ASP A 209 -5.601-32.547-47.655 1.0042.06 A

ATOM 1548 C ASP A 209 -9.-4M^~-29.S33 -48.93-1- 170042.15 A"

ATOM 1549 O ASP A 209 -9.612 -28,954 -49,71O 1.00^"4272I A

ATOM 1550 N ASE A 210 -10.441 -30r829 -48:711 1.00-42.30 A-

.ATOM 1551 CA ASP A 210 -U.720 -30:77-2--49.4071.0043.50 A

Z5 ATOM 1552 GB ASPA 210 -12.703-31.7-81 -48.8051.0044τ47 A

.ATOM 1553 CG ASP A 210 -12.225-3J.209 -48.938 1.0046r97- A-

ATOM 1554 ODl ASPA 2TO -11.476-33.498-49.9061.0047.36 A

ATOM 1555 OD2 ASP A 2LQ -12.619-34.039-48.081 1.0047.45 A

ATOM 1556 C ASP A 210 -12.292-29.360-49.3071.0043.97 A

30 ATOM 1557 O ASP A 210 -12.962-28.868-50.2241.0045.93 A

ATOM 1558 N LEUA 211 -12.011-28.700-48.192 1.0042.97 A

ATOM 1559 CA LEUA 211 -12.485-27.344-47.981 1.0041.72 A

ATOM 1560 CB LEUA 211 -12.471-27.013-46.4871.0042.82 A

ATOM 1561 CG LEU A 211 -13.445-27.759-45.579 1.0042.97 A ₄₂

ATOM 1562 CDl LEU A 211 -13.270-27.287-44.142 1.0044.93 A

ATOM 1563 CD2 LEU A 211 -14.859-27.481-46.038 1.0042.85 A

ATOM 1564 C LEUA 211 -11.675-26.291-48.733 1.0040.66 A

ATOM 1565 O LEU A 211 -12.239-25.381-49.335 1.0040.04 A ATOM 1566 N GLU A 212 -10.353-26.419-48.6881.0039.8-7 A

ATOM 1567 CA GLU A 212 -9.461-25.469-49.3491.0040.22 A

ATOM 1568 CB GLUA212 -8.009-25.848-49.1001.0039.96 A

ATOM 1569 CG GLU A 212 -7.027-24.787-49.5371.0040.42 A

ATOM 1570 CD GLU A 212 -5.600-25.198-49.3171.0041.29 A ATOM 1571 OEl GLU A 212 -4.709 -24.336 -49.440^" 1.0041.21 A

ATOM 1572 QE2 GLU A 212 -5.368 -26.386 -49.025- 1.0044.60 A

ATOM 1573 C GLU A 212 -9.751-25.465-50,8,4.61:0040,60 A

ATOM 1574 O GLUA212 -9.830-24.417-51.483 1.0041.05 A

ATOM 1575 N HIS A 213 -9.940-26.658 -51.384- LOO 40.82 A ATOM 1576 CA HIS A 213 -10.261 -26.825 -52.7S5 1.0041.06 A

ATOM 1577 CB HIS A 213 -10.434-28.293-53.131 1.0043.72 A

ATOM 1578 CG HIS A 213 -9.177-29.091 -53.0741.0047.82 A

ATOM 1579 CD2HISA213 -8.921-30.352-53.4921.0048.57 A

ATOM 1580 NDl HIS A 213 -7.992 -28.607 -52.5541.0050.16 A ATOM 1581 CEl HIS A 213 -7.059-29.540-52.661 1.0051.03 A

ATOM 1582 NE2HISA213^" -7.598-30.-608-53.2271.0050_^17 A

ATOM 158-3 C HIS A 213 -11.608 -2S.176-53.0λ 3 1.0039.23 A

ATOM 15-84 G- HIS-A 213 -11.777-25,290 -53,8321-vOO 40.64 "A-

ATOM- 1585 N LEU A 214.. -12:6Gt -26.649 -52.2861Λ036t39 A\. ATOM- 1586 GA LEUA 214 -13.933-26.097-52.493 1.0034.96 A

ATOM 1587 CB LEUA214 -14.922-2-6.590-51.462 LOO 34.57 A

ATOM 158& CG LEUA^~214 -16.1-80-27.1-80-52.071 1.0034.24 A

ATOM 1589 CDl LEU A 214 -15.996 -28,680 -52.053 1.0033.77 A

ATOM 1590- CD2 LEU A214 -17:399-26.803-51.253 1.0034:65 A ATOM 1591 C LEU A 214 -14.008-24.599-52.4671.0034.69 A

ATOM 1592 O LEU A 214 -14.942-23.995-53.0021.0035.13 A

ATOM 1593 N TYR A 215 -13.036-23.988-51.8181.0033.96 A

ATOM 1594 CA TYRA215 -13.063-22.549-51.7371.0033.10 A

ATOM 1595 CB TYR A 215 -12.222-22.059-50.569 1.0030.94 A ^

ATOM 1596 CG TYRA 215 -12.335-20.578-50.379 1.0026.69 A

ATOM 1597 CDl TYR A 215 -13.515-20.000-49.918 1.0025.14 A

ATOM L598 CEl TYR A 215 -13.623-18.630-49.7671.0023.86 A

ATOM 1599 CD2 TYR A 215 -11.273 -19.751 -50.684 IJOO 24.58 A ATOM 1600 CE2 TYR A 215 -11.372 -18.385 -50.5371.0023.36 A

ATOM 1601 CZ TYRA 213 -12.546-17.827-50.079 1.0022.87 A

ATOM 1602 OH TYRA 215 -12.632-16.464-49.916 1.0024.09 A

ATOM 1603 C TYRA215 -12.552-21.982-53.045 1.0033.38 A

ATOM 1604 O TYR A 215 -13.169-21.077-53:5981.0033.86 A ATOM 1605 N GLN A 216 -11.436-22.521-53.544 1.0033.44 A

ATOM 1606 CA GLNA 216 -10.867 -22i)64 -54.8251.0032.50 A

ATOM 1607 CB GLN A 216 -9.805-23.027-55:353 1.0032.69 A

ATOM 1608 CG GLN A 216 -8.610-23.206-54.470 1.0036.72 A

ATOM 1609 CD GLNA-21& -7.602-24.137-55.101 1.0038.93 A ATOM 1610 OEl GLNA 216 -7.018 -23.811 -56.133 1.0041.29 A

ATOM 1611 NE2GLNA216 -7.399-25.308-54.495 1.0039.46 A

ATOM 1612 C GENA^lό -11.964-21.969-55.8821.0030.82 A

ATOM 1613 O GLN A 216 -12.046-20.983-56.6241.0030.89 A

ATOM 1614 N GLN A 217 -12.796-23.004-55.946 1.0027.30 A ATOM 1615 CA GLNA217 -13.887-23.037-56.8961.0025.33 A

ATOM 1616 CB GLNA 217 -14.-721 -24.305 -56.7171.0027.85 A

ATOM 1617 CG GLN A 217 -14.119-25.544-57.3571.0029,91 A

ATOM 1618 CD GLNhA 217 -L4.967 -2&783 -57.140 LOO 32.00 A.

ATOM 1619- OEl GLN A217 -16.-193 -26.754 -57.3141.0033,31 A ATOM 1620 JVIE2GL-NA217 -1A318 -27.888 -#6τ7621.0032.17 A

ATOM 1621- C GLN A 217 -1^"4.794 -21.841 -56.751 1.00-22.93 -A-

ATOM 1622 O GLN A 217 -15,331 -21,357^".57.73T 1.00-22.1-6- A

ATOM 1623 N- LEU A 218 -14.965-21.366-55.522 1.0021.39 A

ATOM 1624 CA LEUA218 -15.857-20.24f) -55.2601.0019.27 A ATOM 1625 CB LEU. A 218 -16.648-20.499-53.9771.0019.93. A

ATOM 1626 CG LEU A 218 -17.468-21.786-53.853 1.0020.64 A

ATOM 1627 CDl LEU A 218 -17.736-22.099-52.381 1.0021.44 A

ATOM 1628 CD2 LEU A 218 -18.777-21.625-54.6061.0021.58 A

ATOM 1629 C LEUA218 -15.177-18.879-55.151 1.0017.75 A _m

ATOM 1630 O LEUA 218 -15.823-17.855-55.370 1.0015.71 A

ATOM 1631 N GLUA219 -13.880-18.857-54.833 1.0016.42 A

ATOM 1632 CA GLU A 219 -13.196-17.569-54.670 1.0015.74 A

ATOM L633 CB GLUA219 -11.664-17.712-54.562 1.0016.69 A ATOM 1634 CG GLU A 219 -11.002-16.363-54.2641.0019.35 A

ATOM 1635 CD GLU A 219 -9.575-16.461-53.7541.0022.26 A

ATOM 1636 OEl GLU A 219 -9.138-15.522-53.0461.0023.87 A

ATOM 1637 OE2 GLU A219 -8.886-17.454-54.0671.0023.43 A

ATOM 1638 C GLU A 219 -13.512-16.557-55.753 1.Θ014.26 A ATOM 1639 O GLU A 219 -13.796-15.407-55.448 1.0013.37 A

ATOM 1640 N PRO A 220 -13.470 -16.971 -57:035 1.0013.44 A

ATOM 1-641 CD PRO A 220 -13.107 -18.304 -57.542 1.0012.73 A

ATOM 1642 CA PROA220 -13.756-16.062-58.1461.0011.75 A

ATOM 1643 CB ERO A 220 -13.729-16.985 -59.352 LOO 11.74 A ATOM 1644 CG PJRO A 220 -12.714-17.997-58:9571,0012.66 A

ATOM 1645 C PRO A 220 -15.102-15.385-57.9701.0012.40 A

ATOM 1646 O PRO A 220 -15.283-14.207-58.3001.0010.72 A

ATOM 1647 N LEU A 221 -16.046-16.141-57.4301.0013.08 A

ATOM 1648 CA LEUA221 -17.378-15.621-57.211 1.0013.96 A ATOM 1649 CB LEU A 221 -18.268 -16.689 -56τ588 1.0013.73 A

ATOM 1650 CG LEU A 221 -19.445 -17.196-57_^416^" 1.0013.10 A

ATOM- 1651 CDl LEU A 221 -18:943-18.024-58.5691.0014.33 A

ATOM 1652 CD2-LEUA221 -20.332 -18.044 -56r5591.0013.91 Ar

ATOM 1653 C XEUA221 -17.299-14.429-56:2801.9016.33 A ATOM 1654 O- LEUA-221 -17.851 -13JL62 -56T578 hθθ 18:55 A

ATOM 1655 N- TYR A222 -16.607-14.605-55.1561,0015:47 A

ATOM 1-656 GA TYR A 222 -16.484-13.535-54.175.1.0015.61 A

ATOM 1657 CB TYRA 222 -15.766-14,025-52.911 1.0014.35 A

ATOM 1658 CG TYRA 222 -15.598-12.954-51.863 1.0013.23 A ATOM 1659 CDl TYR A 222 -16.710-12.347-51.2821.0014.27 A

ATOM 1660 CEl TYR A 222 -16.576-11.316-50.3541.0013.52 A

ATOM 1661 CD2 TYR A 222 -14.336-12.510-51.483 1.0013.37 A

ATOM 1662 CE2 TYR A 222 -14.192-11.477-50.5461.0014.02 A

ATOM 1663 CZ TYR A 222 -15.322-10.888-49.9951.0013.45 A _43Q

ATOM 1664 OH TYR A 222 -15.209 -9.855-49.101 1.0016.83 A

ATOM 1665 C TYR A 222 -15.740-12.343-54.743 1.0016.73 A

ATOM 16660 TYRA222 -16.269-11.227-54.7701.0017.27 A

ATOM 1667 N LEU A 223 -14.511 -12.584-55.1901.0017.08 A ATOM 1668 CA LEU A 223 -13.677 -1L533 -55.7571.0017.29 A

ATOM 1669 CB LEU A 223 -12.514-12.143-56.523 1.0017.40 A

ATOM 1670 CG LEUA223 -11.509-12.944-55.7021.0017.61 A

ATOM 1671 CDl LEU A 223 -10.405-13.467-56.613 1.0018.11 A

ATOM 1672 CD2 LEU A 223^" -10.915-12.052-54.638 1.0018.05 A ATOM 1673 C LEUA223 -14.448-10.599-56.681 1.0018.10 A

ATOM 1674 O LEUA-223 -14.178 -9.396-56.699 LOO 17.75 A

ATOM 1675 N ASN A 224 -15.395-11.144-57.4501.0018.40 A

ATOM 1676 CA ASNA224 -16.170-10.314-58.358 1.0018.39 A

ATOM 1677 CB ASN A 224 -16.748-11.144-59.5071.0017.47 A ATOM 1678 CG ASNA 224 -15.834-11.151-60.723 1.0016.66 A

ATOM 1679 ODl ASN A 224 -15.646-10.127-61.372 1.0015.52 A

ATOM 1680 ND2 ASN A 224 -15.246-12.301-61.0221.0015.87 A

ATOM 1681 C ASN A 224 -17.262 -9.540 -57.646 LOO 19.34 A

ATOM 1682 O ASN A 224 -17.466 -8.363-57.9461.0020.98 A ATOM 1683 -N LEU A 225 -17.957-10.174-56.703 1.0018.80 A

ATOM 1684 CA LEU A 225 -18.995 -9.459-55,971 1.00-16.99 A

ATOM 1685 CB LEUA.225 -19:672-10.365-54.9541.0017.72^" A

ATOM 1686 CG LEU A 225 -20.758 -9.664-54.1391.0017.43 A

ATΘM: 1687 CD1EEUA-225 -21.823 -9.119. -55.0.861.0014.91 A ATOM 1688 CD2 LEU A 225 -2Ω56 -l-0,65L-53JL191.0017.23 A_

ATOM -1689 C LEU A 225 -T&284 -8.344-55.24.6 l.θθ 16.2T A

ATOM T690 O LEU A 225 -1-&.803 -7.251 -55J-041.Θ016.53 A

ATOM 1691 N fflSA^26 -17.061 -8.635-54.8121.0015.87 A

ATOM 1692 CA fflS A 226 -16.216 -7.691-54.094 1.0015.99 A ATOM 1693 CB HIS A 226 -14.927 -8.408-53.662 1.0017.77 A

ATOM 1694 CG HIS A 226 -13.988 -7.560-52.858 1.0017.72 A

ATOM 1695 CD2 HIS A 226 -13.446 -7.748-51.6351.0017.85 A

ATOM 1696 NDl HIS A 226 -13.435 -6.397-53.345 1.0019.72 A

ATOM 1697 CEl HIS A 226 -12.587 -5.909-52.458 1.0018.10 A ,,,

431

ATOM 1698 NE2 HIS A 226 -12.574 -6.711-51.413 1.0017.61 A

ATOM 1699 C HIS A 226 -15.893 -6.434-54.9161.0015.33 A

ATOM 1700 O HIS A 226 -16.327 -5.343 -54.5621.0013.37 A

ATOM 1701 N ALA A 227 -15.143 -6.579-56.0081.0015.60 A ATOM 1702 CA ALA A 227 -14.781 -5.430-56.8501.0014.00 A

ATOM 1703 CB ALA A 227 -14:049-5.907-58.071 1.0012.86 A

ATOM 1704 C ALA A 227 -15.983 -4.578-57.2691.0013.28 A

ATOM 1705 O ALA A 227 -15.885 -3.346-57.3671.0012.64 A

ATOM- 1706^~N PHE A 228 -17.112-5.242-57.5041.0012.59 A ATOM 1707 CA PHE A 228 -18.356 -4.589 -57.91Θ 1.0012.78 A

ATOM- 1708- CBr EHEA 22« -19.407 -5.655-58.264- 1.00-13.75 A

ATOM 1709 CG PHE A-228 -20.715 -5-.094 -58.7761.0015.84- A

ATOM 1710 CDl PHE A 228 -20.816 -4.582-60.0621.0017.55 A

ATOM 1711 CD2PHEA228 -21.848 -5.090-57.9741.00:16.56 A ^" ATOM 1712 CEl PHE A-228 -22.017 -4.079-60.5351.0016.90^" A

ATOM 1713- CE2 PHE A 228 -23.050 -4.590-58.4451.0017.54 A

ATOM 1714 CZ PHE A 228 -23.132 -4.085 -59.7281.001-6.76 A

ATOM 1715 C PHEA228 -18.900 -3.683-56.813 1.0013.64 A

ATOM 1716-O PHE A 228 -19.312 -2.557-57.078 1.0014.18 A ATOM 1717 N VAL A 229 -18.920 -4.193 -55.5821.0012.60 A

ATOM 17T8 CA VAL A 229 -19.405 -3.432-54.448 1.0010.36 A

ATOM 1719 CB VAL A 229 -1-9.62-7 -4.334-53 J222_ 1.0011.81 A

ATOM 1720 CGl VAL-A-229 -19.959 -3L493 -51.995 1.009.80 A

ATOM 1721 CG2 VAL A 229 720.759 -5.309 -53.506 L.M-13.31 -A - ATOM 1722 C VALA 229 -18:382 -2.387-54.093 1.009.54 A

ATOM 1723 O VALA.229 -1-8.7-26 -Iτ263^" -53.786 1.00 l^"0J9 A

ATOM- 1724 N ARGA 230 -17.1-12^" -2.756-54.140 1.009τl6 A

ATOM 1725 CA ARG-A 230 -16,058 -1.809 -53. &00 1.0010.61 A

ATOM 1726 CB ARG A 230 -14.673 -2.435-53.995 1.0010.18 A ATOM 1727 CG ARG A 230 -13.530 -1.521 -53 J891.0010.59 A

ATOM 1728 CD ARG A 230 -12.202 -2.219-53.710 1.0012.98 A

ATOM 1729 NE ARG A 230 -11.905 -2.587-55.0861.0016.13 A

ATOM 1730 CZ ARG A 230 -10.962 -3.455-55.4371.0015.50 A

ATOM 1731 NHl ARG A 230 -10.221 -4.050-54.5291.0014.50 A ^

ATOM 1732 NB2 ARG A 230 -10.761 -3.738 -56.703 1.00 18.61 A

ATOM 1733 C ARG A 230 -16.178 -0.579 -54.677 1.00 11.81 A

ATOM 1734 O ARG A 230 -15.834 0.534 -54.296 1.00 12.28 A

ATOM 1735 N ARG A 231 -16.682 -0.771 -35.872 1.00 12.96 A ATOM 1736 CA ARG A-231 -16.773 0.375 -56.717 1.00 14.62 A

ATOM^" 1737 CB ARG A 23J -16.564 -0.116^~-58.139 1.00 18.87 A

ATOM 1738 CG ARGA 231 -17.098 0.761 -59.176 1.0021.24 A

ATOM 1739 CD ARGA 231 -16.030 1.563 -59.725 1.0023.51 A

ATOM 1740 NE ARG A 23-1 -16,475 1.994 -6-1.026 1.00 30.23 A ATOM 1741 CZ ARG A 231 -15.740 2.716 -61.840 1.00 33.19 A

ATOM 1742 NHl ARG A 231 -16.219 3.073 -63.018 1:00 35.63 A

ATOM 1743 NH2 ARG A 231 -14.532 3.071 -61.455 1.00 36.-54 A

ATOM 1744 C ARGA 231 -18.091 1.120 -56.457 1.00 14.12 A

ATOM -1745 O ARG A 23-1 -18.159 2.343 -56.512 1.00 12.78 A ATOM 1746 N ALA A 232 -19.143 0.392-56.134 1.00 14.76 A

ATOM 1747 CA ALAA 232 -20.379 1.076 -55.821 J.00 16.81 A

ATOM 1748 CB ALA A 232 -21.494 0.075 -55.526 1.00 17.40 A

ATOM 1749 C ALA A 232 -20.056 1.916 -54.575 1.00 18.51 A

ATOM 1750 O ALA A 232 -20.488 3.057-54.463 1.00 18.98 A ATOM 1751 N LEU A 233 -19.254 1.377 -53.661 1.00 19.34- A

ATOM 1752 CA LEU A233 -18.91T 2.121 -52.450 1.0021.79 A

ATOM L753 CB LEU A233 -18.231 1T2T4 -51.405 1.00-22.72 A

-ATOM 1754- CG LEU-A 233 -19.154- 0.308 -5X1564 l-.θθ 24.22 A

ATOM 1755 CD=IiEU A23S -18.340 -0r498 -4-9.575 1.00:21.59 A ATOM 1756 CD2 LEUΑ- 233 -20.192 1.152--49.82I 1.00^"25.4O A

ATOM^" 1757 -C LEU A 233 -18.054 3.344 -52.725 1:0023.27 A

ATΘM- 175& O LEU A 233 -18.274 4.417 -52.157 1.0023.8* A

ATOM 1759 N HIS A 234 -17.069 3.185.-53.595.- 1.00 24.52. A

ATOM 1760 CA HIS A 234 -16.189 4.292-53.948 1.0025.47 A ATOM 1761 CB HIS A 234 -15.282 3.873 -55.107 1.0025.82 A

ATOM 1762 CG HIS A 234 -14.366 4.955 -55.592 1.0024.97 A

ATOM 1763 CD2 HIS AJ234 -13.103 5.282 -55.229 1.0025.15 A

ATOM 1764 NDl HIS A 234 -14.726 5.853 -56.571 1.00 24.85 A

ATOM 1765 CEl HIS A 234 -13.724 6.687 -56.790 1.0024.96 A _m

ATOM 1766 NE2 HIS A 234 -12.728 6.363 -55.988 1.00 23.91 A

ATOM 1767 C HIS A 234 -17.084 5.448 -54.361 1.0026.79 A

ATOM 1768 0 HIS A 234 -16.918 6.593 -53.923 1.00 28.11 A

ATOM 1769 N ARG A 235 -18.055 5.107 -55.199 1.00 27.23 A ATOM 1770 CA ARG A 235 -19:040 6.051 -55.710 1.00 27.72 A

ATOM 1771 CB ARG A 235 -20.139 5.285 -56.432 1.00 29.40 A

ATOM 1772 CG ARG A 235 -20.550 5.909 -57.739 1.00 33.41 A

ATOM 1773 CD ARG A 235 -20.518 4.854 -58.836 1.00 35.86 A

ATOM 1774 NE ARGA 235 -21.428 3.738 -58:577 1.00 39Λ8 A ATOM 1775 CZ ARG A 235 -21.393 2.579 -59.230 1.0041.03^" A

ATOM 1776 NHl ARG A 235 -20.4SO 2.415 -60.177 1.00-40.29 A

ATOM 1777 NH2 ARG A 235 -22-252- 1.593-58.930 1.00 40.81 A

ATOM 1778 C ARG A 235 -19.703 6.925 -54.657 1.0027.13 A

ATOM 1779 O ARGA 235 -20.021 8.076 -54.899 1.0027.37 A ATOM 1780 N ARG A 236 -19.907 6.364 -53.477 1.0026.91 A

ATOM 1781 CA ARGA 236 -20.587 7.087 -52.418 1.0025.46 A

ATOM 1782 CB ARG A 236 -21.594 6.111 -51.754 1.00 26.44 A

ATOM 1783 CG ARG A 236 -21.789 6.216 -50.241 1.0027.38 A

ATOM 1784 CD ARG A 236 -22.966 7.124 -49.815 1.0029.19 A ATOM 1785 NE ARG A 236 -24.313 6.524 -49.903 1.00 30.58 A

ATOM 1786 CZ ARG A 236 -25.444 7.153 -49.565 1.0030.26 A

ATOM 1787 NHl ARG-A 236 -J25J99 8.400 -49.115^" 1.00 29,47 A

-ATOM 1788 NH2 ARG A 236 -26τ617 6-537-49:079- 1.00:29.26 A

ATOM 1189 C ARG-A 236- -19.699 7 J91 -51.399 1.00 24.22 A ATOM- 1790 O ARG A 236 -19.975 8.927 -51.01T 1.00 24.05 A

ATOM 1791 N- TYR-A 237 -1S.618 7X44-50:981 1.00 22.53 A

ATOM 1792 CA TYH A 237 -17.733 7.769 -49.995 1.QO20L75 A

ATOM 1793 CB TYH A 237 -17.230 6.745 -48.989 1:00 18.44 A

ATOM 1794 CG TYR A 237 -18,347 6.047 -48.266 1.00 15.88 A ATOM 1795 CDl TYR A 237 -18.617 4.707 -48.510 1.00 15.66 A

ATOM 1796 CEl TYR A 237 -19.642 4.045 -47.838 1.00 14.85 A

ATOM 1797 CD2 TYR A 237 -19.134 6.721 -47.333 1.00 13.61 A

ATOM 1798 CE2 TYR A 237 -20.168 6.069 -46.655 1.00 13.20 A

ATOM 1799 CZ TYRA 237 -20.415 4.728 -46.915 1.00 13.99 A _m

ATOM 1800 OH TYR A 237 -21.433 4.052 -46.281 1.00 12.33 A

ATOM 1801 C TYR A 237 -16.554 8.486 -50.601 1.0020.16 A

ATOM 1802 O TYRA 237 -15.867 9.241 -49.916 1.0020.31 A

ATOM 1803 N GLY A 238 -16.305 8.248 -5L880 1.00 18.97 A ATOM 1804 CA GLY A 238 -15.213 8.948 -52.515 1.00 18774 A

ATOM 1803 C GLY A 238 -13.896 8.237 -52.685 1.00 19.05 A

ATOM 1806 O GLYA 238 -13.769 7.029 -52.495 1.00 18.48 A

ATOM 1807 N ASP A 239 -12.893 9.030 -53.024 1.00 19.72 A

ATOM 18O8- CA ASP A 239 -11.570 8.514 -53.288 1.00-21.55 A ATOM 1809 CB ASP A 239 -10.942 9.323 -54.422 LOO 21.57 A

ATOM 1810 -CG ASP A 239 -9.970 £514 -55.211 1:0021.35 A

ATOM 1811 ODl ASP A 239 -10.424 7.501 -55.788 1.00 19.75 A

ATOM 1812 OD2 ASP A 239 -8.768 8.875 -55.236 1.00 21.26 A

ATOM 1813 C ASP A 239 -10.627 8.490 -52.094 1.00 22.45 A ATOM 1814 O ASP A 239 -9.594 7.822 -52.134 1.00 23-68 A

ATOM 1815 N ALA A 240 -10.973 9.220 -51.039 1.00 23.89 A

ATOM 1816 CA ALA A 240 -10.136 9.274 -49.847 1.00 23.30 A

ATOM 1817 CB ALA A 240 -10.430 10.539 -49.053 1.0023.88 A

ATOM 1818 C ALA A 240 -10.364 8.061 -48.972 1.00 23.20 A ATOMr 1819 O ALA A 240 -9.413 7.473 -48.472 1.00 23.84 A

ATOM 1820 N TYR A 241 -11.626 7.681 -48.812 1,0022.77 A

ATOM 1821 CA TYR A 241 -11.980 6.565 -47:953 1.0023.87 A

ATOM 1822 CB TYRA241 -13.354 6.824 -47.342 1.00_26:40 A

ATOM^" 1823- CG TYR A 241- -13.365_ 8.012-46.390 1.00 30.51 A ATOM 1824- CDl JTR A-241 -14.495 8.833 -46.269 1.00 32.03 A

ATOM 1825 CEl TYR A 241 -14.5-15 9:930 -45.397 1.00 33.39 A

ATOM 1826 CD2 TYR-A 241 -127248 8:319 -45.607 h00 32.19 A

ATOM 1827 CE2 TYRA 241 -12.25« 9.416 -44.730 1.0034.30 A

ATOM 1828 CZ TYR A 241 -13.396 10.216 -44.632 1.0034.81 A ATOM 1829 OH TYR A 241 -13.414 11.295 -43.768 1.00 36.17 A

ATOM 1830 C TYRA241 -11.950 5.193 -48.607 1.0023.52 A

ATOM 1831 O TYRA241 -11.766 4.177 -47.929 1.0023.86 A

ATOM 1832 N ILE A 242 -12.128 5.149 -49.923 1.0023.08 A

ATOM 1833 CA DLE A 242 -12.106 3.871 -50.634 1.0020.51 A ATOM 1834 CB ILE A 242 -13.417 3.634 -51.376 1.00 18.90 A

ATOM 1835 CG2 ELE A 242 -13.421 2.245 -51.944 1.00 18.39 A

ATOM 1836 CGl ILE A 242 -14.596 3.842 -50.424 1.00 18.90 A

ATOM 1837 CDl ILE A 242 -15.526 2.667 -50.298 1.00 16.95 A ATOM 1838 C ELE A242 -10.960 3.797 -51.637 1.0Θ 19.34 A

ATOM 1839 O ILE A 242 -10.658 4.775 -52.303 1.0020.31 A

ATOM 1840 N ASN A 243 -10.302 2.644 -51.711 1.00 18.61 A

ATOM 1841 CA ASN A 243 -9.209 2.446 -52.663 1.00 18.27 A

ATOM 1842 CB ASN A 243 -7.93D 1-.987 -51.967 1.0016.65 A ATOM 1843 CG ASNA 243 -6.808 1.733 -52.952 1.00 18.14 A

ATOM 1844. ODI ASN A 243 -7.054 1.295 -54.081 1.00 20,76 A

ATOM 1845 ND2 ASN A 243 -5.574 2.009 -52.543 1.00"14τ95 A

ATOM 1846 C ASN A 243 -9.649 1.380 -53.676 1.00 17.92 A

ATOM 1847 O ASN A 243 -9.84-1 0,214 -53.323 1.00 18.07 A ATOM 1848 N LEU A 244 -9.803 L790 -54.931 1.00 16.38 A

ATOM 1849 CA LEU A 244 -10.255 0.895 -55.995 1.0045.79 A

ATOM 1850 CB LEU A 244 -10.485 1.721 -57.264- 1.00 14.45 A

ATOM 1851 CG LEU A 244 -11.680 2.671 -57.187 1.00 13.70 A

ATOM 1852 CDl LEU A 244 -11.731 3.573 -58.415 1.00 14.72 A ATOM 1853 CD2 LEUA 244 -1-2.954 1.839 -57.065 1.00 11.27 A

ATOM 1854 C LEU A 244 -9.30σ -0.268 -56J277 1.00 14.69 A

ATOM 1855 O LEU A 244 -9.595 -1.161 =57.065 1.00 13.OG- A

ATOM 1856 N ARG A 245 -8.157 -0.24J -55.605 LOO 14.51 A

A3EΘM 1-857 CA ARG A 245- -7.117 -1.234 -55.756 l.θθ 14.69 A ATDM 1858 CB ARG AJ2£5 -5.903 -0.633^56.389 T..00 17:52 A

ATOM L859 CG ARGA 245 -5.758" -0.943^" -57.825 1.0021.27 A

ATOM 1860 CD ARG A- 245 -5.678 0.350. -58.547 1.00124.86 A

ATOM 1861 NE ARG A 245 -4.309 0.681 -58.929 1.O0 28.00 A

ATOM 1862 CZ ARG A 245 -3.624 1.721 -58.462 1.00 30.86 A ATOM 1863 NHl ARG A 245 -4.179 2.530 -57.574 1.00 31.1-8 A

ATOM 1864 NH2 ARG A 245 -2.400 1.975 -58.919 1.00 31.75 A

ATOM 1865 C ARG A 245 -6.656 -1.804 -54.442 1.00 14.88 A

ATOM 1866 0 ARG A 245 -5.586 -2.405 -54.376 1.00 14.85 A

ATOM 1867 N GLY A 246 -7.439 -1.582 -53.394 1.00 13.82 A _m

ATOM 1868 CA GLY A 246 -7.062 -2.057-52.0821.0011.75 A

ATOM 1869 C GLY A 246 -8.223 -2.734-51.405 1.0011.17 A

ATOM 1870 O GLY A 246 -9.308 -2.782-51.980 1.0011.59 A

ATOM 1871 N PRO A 247 -8.035 -3.267-50.1871.009.40 A

5 ATOM 1872 GD PRO A 24.7 -6.855 -3.158 -49.323 1.008.28 A

ATOM 1873 CA PRO A 247 -9.120 -3.936-49.4791.008.86 A

ATOM 1874 CB PRO A 247 -8.406 -4.581-48.3171.007.77 A

ATOM 1875 CG PRO A 247 -7.405 -3.594-47.995 1.007.47 A

ATOM 187&C PRO A 247 -10.133 -2.912-49.028 1.0010.51 A-

10 ATOM 1377 O PRO A 247 -9.788 -1.750-48.8201.0011.22 A

ATOM- 1-878 N ILE A 248 -11.3.88 -3.333-48.899 1.0012.75 A

ATOM 1879 CA ILE A 248 -12.452 -Z429 -48.458 1.0014.69 A

ATOM 1880 CB ILE A 248 -13.832 -2.994-48.798 1.0012.49 A

ATOM 1881 CG2 DLE A 348 -14.907 -1.987-48.413 1.0011.78- A

15 ATOM 188-2 CGl ILE A 248 -13.904 -3.319-50.2831.0.011.23 A

ATOM 188-3 CDl ILE A 248 -15.127 -4.101-50.6561.0011.06 A

ATOM 1884 C ILE A 248 -.12.391 -2.232-46.9361.0016.52 A

ATOM 18850 DLE A 248 -12.057 -3.163 -46.1941.0017.79 A

ATOM 1886 N PRO A 249 -12.696 -1.017-46.451 1.0016.77 A

JZO ATOM 1887 CD PRO A 249 -12.800 0.237-472151.0016.58 A

ATOM 1888 CA PROA 249 -12.669 -0.747-45.003 1.0016,81 A

ATOM 1889 CB -PRO A 249 -12,834 CL769 -44V93Φ 1.0016.81 A

ATOM -1890 CG PRO A 249 -12.230 1.233 -46.243 LOO 17v94 A-

ATOM -1-891 C PRO A 249 -13:820 -1.508-44.325 1,0016.63 A

25 ATOM 1892 O PRO A 249 -14.990 -1.293 -44.6511,0016τ67 A

ATOM 1-893 N ALA A 250: -13,473 -2.386-43.3831-.0015.94 A-

ATOM 1-894 CA ALA A 250 -14.419--3:259 -42.671 1.0015:01 A

ATOM 1895 CB ALA A 250 -13.669 -4.0L0. -41.597 LOO 15.40 A

ATOM 1896 C ALA A 250 -15.744 -2.742-42.087 1.0014,22 A

30 ATOM 1897 O ALA A 250 -16.609 -3.541-41.734 1.0013.69 A

ATOM 1898 N HISA251 -15.928 -1.435-41.989 1.0013.95 A

ATOM 1899 CA HISA251 -17.169 -0.919-41.428 1.0013.58 A

ATOM 1900 CB HIS A 251 -16.852 0.188-40.4461.0011.76 A

ATOM 1901 CG HISA251 -16.196 1.371-41.0741.0010.39 A _43?

ATOM 1902 CD2HISA251 -16.561 2.673-41.124 1.0011.01 A

ATOM 1903 NDl HIS A 251 -14.981 1.289-41.713 1.009.51 A

ATOM 1904 CEl HIS A 251 -14.622 2.492-42.1251.009.85 A

ATOM 1905 NE2 HIS A 251 -15.563 3.351-41.7801.0010.29 A ATOM 1906 C HIS A 251 -18.189 -0.3S4 -42.422 LOO 14.96 A

ATOM 1907 O HIS A 251 -19.219 0.148-42.0141.0014.91 A

ATOM 1908 N LEU A 252 -17.933 -0.535-43.7181.0016.66 A

ATOM 1909 CA LEU A 252 -18.845 0.008-44.7241.0017.11 A

ATOM 1910 CB LEU A 252 -18.035 0.727-45.793 1.0017.85 A ATOM 1911 CG LEU A 252 -17.118 1.781-45.1621.0020.88 A

ATOM^" 1912 CDlLEU A 252 -16.176 2.364-46.2001.0021.91 A

ATOM^' 1913 CD2 LEU A 252 -17.968 2.886-44.540 1.0021.11 A

ATOM 1914 C LEUA252 -19.758 -1.005-45.3821.0017.11 A

ATOM 1915 O LEU A 252 -20.673 -0.632-46.106 -1.00:16.24 A ATOM 1916 N LEUA 253 -19.517 -2.285 -45^".12O 1.0017.78- A

ATOM 1917 CA LEU A 253 -20.308 -3.342-45.733 1.0018.06 A

ATOM 1918 CB LEUA253 -19.516 -4.644-45.7271.0017.29 A

ATOM 1919 CG LEU A 253 -18.244 -4.642-46.5861.0018.06 A

ATOM 1920 CDl LEU A 253 -18.602 -4.514 -48.043 l.GΘ 17.54 A ATOM 1921 CD2 LEU A 253 -17.366 -3.463-46.201 1.0020.34 A

ATOM 1922 C LEUAJ253 -21.661 -3.569-45.099 l.Ott 20.03 A

ATOM^" 1923 O -LEUA 253 -22.293. -4.585 -45.348 1.0Θ20.44 A

ATOM.1924 N GLY A 254 -227084 -2.634-44.2521.00-22.21 A

ATOM 1925 CA: GLY A 254 -23-.3-7& --2J722 -43,583 JLM 23.15 A ATOM 1926 C GLY A 254 -23.599 -3.743 -^'42.468 1,00:24.13- A

ATOM- 1-927-0 GLY A 254^" r24.746 -3.9S6 -42.σ68 h0023~04 A

ATOM 1928 N A-SPA 255 -22.516-4.330-41.960- 1-ΘO 24.98 A

ATOM 1929 CA ASP A 255 -22J87 -5.330 -40.9001.0025.91 A

ATOM 1930 CB ASP A 255 -22.844 -6.692-41.513 1.0026J7 A ATOM 1931 CG ASP A 255 -22.639 -7.806-40.5371.0029.64 A

ATOM 1932 ODl ASP A 255 -21.467 -8.067-40.195 1.0030.49 A

ATOM 1933 OD2ASPA255 -23.645 -8.418-40.108 1.0032.96 A

ATOM 1934 C ASPA255 -21.280 -5.332-40.1151.0026.77 A

ATOM 1935 O ASP A 255 -20.204 -5.395-40.7091.0027.46 A ATOM 1936 N MET A 256 -21.393 -5.283-38.7841.0027.19 A

ATOM 1937 CA MET A 256 -20.244 -5.205-37.8571.0026.40 A

ATOM 1938 CB MET A 256 -20.723 -5.505-36.4091.0025.51 A

ATOM 1939 CG MET A 256 -19.704 -5.265-35.2941.00^1.71 A ATOM- 1940 -SD=MET A 256 -18.958 -3.616-35.2991.0021.92 A-

ATOM- 1941 CE MET A 256 -_20;204- -2.618-34.4801.0020.07 A

ATOM 1942 C MET A 256 -19.017 -6.038-38.2141.0025.66 A

ATOM 1943 O MET A 256 -17.886 -5.621-37.9751.0025.24 A

ATOM 1944 N TRPA157 -1-9,226 -7.193-38.819 l.θθ 26.14 A ATOM 1945 CA TRP A 257 -18.099 -8.042 -39.173 l.GO 28.47 A

ATΘM- 1946 CB- TRP A 257 -T8.327 -9:439-3-8.5871.0030,56- A

AT-OM 1947 CG TRPA 257^" -18:608 -9.363-37.1291.0032.44 A

ATOM 1948 CD2TRPA257 -19.897 -9.334-36.509 1.0033.76 A

ATOM 1949 CE2 TRP A 257 -19.693 -9.066-35.142 1.0033.44 A ATOM 1950- CE3 TRP A 257 -21.205 -9,499 -36.9791.0034.-52 A

ATOM 1951 CD1TRPA257 -17.703 -9.131-36.1361.0032.45 A

ATOM 1952 NEl TRP A 257 -18.344 -8.947-34.945 1.0033.17 A

ATOM 1953 CZ2 TRP A 257 -20.747 -8.956-34.2361.0033.32 A

ATOM 1954 CZ3 TRP A 257 -22.253 -9.386-36.0771.0035.34 A ATOM 1955 CH2 TRP A 257 -22.014 -9.116-34.719 1.0033.84 A

ATOM 1956 Cl TRP A 257 -17.883— 8rl20 -40.6751.0027.67 A

ATOM K57O TRP A 257 -16:932 -8.74J-4U35 1.00-25.75 A

ATOM 1-958 N ALA A 258 --18.748 -7,469-41.425 1.0028=4-9 A

ATOM 19.59^'CA ALA A 258 -18.701 -7.469 -42^791.0029.79- A ATOM I960- CB ALA A 25S- -L7.343 -6.967^~-43.3351.0029.71 A

ATOM, 1961 C ALA A 258 -18.935 =8:88-1 -43.4071.9030.53 A

ATOM— 1962 Q-ALA A 258^" -18.424 -9:245-44.4591.0031.14 A

ATOM 1963 N GEN A 259 -19^707 -9.676-42.6721.0031.63 A

ATOM 1964 CA GLN A 259 -19.984-11.051-43.074 1.0031.27 A ATOM 1-965 CB GLN A 259 -20.273 -11.918 -41.8421.0032,89 A

ATOM 1966 CG GLN A 259 -21.429-11.449-40.968 1.0035.15 A

ATOM 1567 CD GLN A 259 -21.727-12.433-39.8541.0036.96 A

ATOM 1968 OEl GLN A 259 -20.849-12.776-39.061 1.0038.73 A

ATOM 1969 NE2 GLN A 259 -22.966-12.899-39.7941.0037.07 A ATOM 1970 C GLN A 259 -21.111-11.202-44.0971.0029.91 A

ATOM 1971 O GLN A 259 -21.206-12.237-44.7571.0030.25 A

ATOM 1972 N SER A 260 -21.969-10.191-44.2201.0027.92 A ATOM 1973 CA SER A 260 -23.050 -10.228-45.205 1.0027.79 A ATOM 1974 CB SERA 260 -24.-262^" -10.983-44.664 LOT) 27.23 A ATOM 1975 OG SERA 260 -24.681 -10.452-43.4321. OO 3.1.58 A

ATOM 1976 C SER A 260 -23.392 -8.788-45.566 1.0027.45 A

ATOM 1977 O SER A 260 -23.614 -7.956-44.685 1.0027.35 A

ATOM 1978 N TRP A 261 -23.439 -8.501 -46:865^" 1.0026.13 A ATOM 1979 CA TRP A 26.1 -23.648 -7.139-47.324 1.0025.38 A

ATOM 1980 CB TRP A 261 -22.670 -6.858-48.468 1:00-25:96 A ATOM. 1981 CG TRPA 261 -21.279 -7.381^" -48.222 1.0025:97 A ATOM 1982 CD2 TRP A 261 -20.196 -7.449-49.1621.0027.04 A ATOM 1983 CE2 TRP A 261 -19.084-7.991-48.4771.0027.27 A ATOM 1984 CE3 TRP A 261 -20:054 -7.106 -50.5Ϊ5 1.0027.72 A- ATOM 1985 CDl TRP A 261 -20.790 -7.869-47.052 -1.0026.05 A ATOM 1986 NEl TRP A 261 -19.479 -&239 -47.191 1.0025.51 A ATOM 1987 CZ2TRPA261 -17.842 -8.200-49.095 1.0028.46 A ATOM 1988 CZ3 TRP A 261 -18.816 -7.314-51.1-33 1.0028.30 A ATOM 1989 CH2 TRP A 261 -17.727 -7.858-50.4171.0028.83 A

ATOM 199-0 C TRP A 261 -25,05.7- -6.7.69 -47.7591J3025.12^" A

ATOM 1991 O TRP A 261 -25.28.7^" -5:665 -48.2521.00-24.44 A

ATOM 1992 N GLUA-262 -26:001- -7.67.8 -47.565 1.002543- A AT-ΘM- 1993^"CA GLUA^62- -277352^" -7.434 -47.977" 1.00-26.95 A ATOM -1-994 CB- GLU A.262 -28:271-8:608-47:64-1 fcθO 2&81 A ATOM 1995 CG GLUA^~262 -27.553 -9.700 -46.914 HXB2.18- A ATOM 1996- CD GLU A 262 -27:990 -9J58 -45.463 LOO 34.37 A ATOM 1997 OEl GLUA 262 -29.109 -9.413-45.0941.0036x19 A ATOM 1998 OE2GLUA262 -27.199-10.454-44.701 LOO 34.79 A ATOM 1999 C GLU A 262 -28.049 -6.228-47.4191.0027.14 A

ATOM 2000 O GLU A 262 -29.215 -5.996-47.689 1.0027.89 A

ATOM 2001 N ASN A 263 -27.336 -5.469-46.611 1.0027.94 A ATOM 2002 CA ASN A 263 -27.929 -4.277-46.033 1.0028.11 A ATOM 2003 CB ASN A 263 -27.613 -4.156-44.555 1.0028.97 A _44Q

ATOM 2004 CG ASN A 263 -28.805 -4.421 -43.688 1.00 30.01 A

ATOM 2005 ODl ASN A 263 -29.812 -3.712 -43.762 1.00 31.60 A

ATOM 2006 ND2 ASN A 263 -28.708 -5.461 -42.852 1.00 30.83 A

ATOM 2007 C ASN A 263 -27.408 -3.062 -46.719 1.0028.29 A ATOM 2008 O ASN A 263 -27.540 -1..961 -46225 1.00-2&47 A

ATOM 2009 N BLE A 264 -26.757 -3.258 -47.843 1.0028.73. A

ATOM 2010 CA ILE A 264 -26.284 -2.110 -48.575 1.00 30.76 A

ATOM 2011 CB ILE A 264 -24.720 -1.964 -48.552 1.0029.9-8 A

ATOM 2012 CG2 DLE A 264 -24.252 -1.583 -47.179 1.0028:84 A ATOM 2013 CGl ILE A 264 -24.037 -3.246 -49.006 1.00 29.90 A

ATOM 20 L4 CDl ILE A 264 -22.534 -3.079 -49.156 1.00-29:03 A

ATOM 2015 C ILE A 264 -26.819 -2.272-49.993 1:0032.26 A

ATOM 2016 O ILE A 264 -26.442 -1.544 -50.903 1.00 32.70 A

ATOM 2017 N TYRA 265 -27.738 -3.223- -50.145 1.00 33.28 A ATOM 2018 CA TYR A 265 -28.370 -3.526 -5 L423 1.00 34.00 A

ATOM 2019 CB TYR A 265 -29.578 -4.436 -51.196 1.00 35.17 A

ATOM 2020 CG TYR A 265 , -30.417 -4.714 -52,421 1.00 36.93 A

ATOM 2021 CDl TYR A 265 -29.908 -5,449 -53.486 1.0038.00 A

ATOM 2022 CEl TYR A 265 -30.687 -5.729 -54.608 1.00 38.24 A ATOM 2023 CD2 TYRA 265 -31.735 -4.259 -52.505 1.00 37.89 A

ATOM 2024- CE2 TYR A 265 -32.523- -4.530 -53.621 1,603.7.94 A

ATOM 2025 CZTYRA 265 -31.993 -5.266 -54.666 1.0038.17 A

AXOM- 2026 OH- TYR A 265 -32.7JQ -5.543 -55,764 1.003&60 A

ATOM 2027 C TYRA-265 -2-8.818 3T.271 -52.157 1.00c34.48 A A31QM 2028 O TYR A 265 -28.694 -2.180 -53.373 1.0035.1-9^~ A

ATOM 2029 N ASF A 266^" -293-37- -1.301 -5-1.417 T.θθ 34.73- A

ATOM 2030 -XJA ASP A 266 -29.820 -0:067 -52.021 1.00 35.21- A

ATOM 2031 CB ASP A 266 -30.625 9.74.1 -50.995 1.00 35.74 A

ATOM 2032 CG ASE A 266 -29.854 0.990 -49.707 1.00 36.66- A ATOM 2033 ODl ASP A 266 -29.566 -0.004 -49.000 1.00 36.46 A

ATOM 2034 OD2 ASP A 266 -29.539 2.171 -49.406 1.00 34.53 A

ATOM 2035 C ASP A 266 -28.700 0.792 -52.589 1.0035.44 A

ATOM 2036 O ASP A 266 -28.960 1.792 -53.247 1.0035.48 A

ATOM 2037 N MET A 267 -27.456 0.404 -52.335 1.00 36.22 A ^l

ATOM 2038 CA MET A 267 -26.307 1.161-52.830 1.0037.30 A

ATOM 2039 CB MET A 267 -25.287 1.391-51.711 1.0039.06 A

ATOM 2040 CG MET A 267 -25.678 2389 -50.643 1.0042.06 A

ATOM 204Ϊ SD MET A 267 -24.386 2.473-49.381 1.0045.47 A ATOM 2042 CE MET A 267 -23.464 3.770-49.9521.0042.49 A

ATOM 2043 C MET A 267 -25.597 0.451-53.9791.0036.75 A

ATOM 2044 O MET A 267 -24.740 1.030-54.6521.0036.03 A

ATOM 2045 N VAL A 268 -25.941 -0.809-54.1941.0036.36 A

ATOM 2046 CA VAL A-268 -25.309 -1,563 -55.255^' 1.0037.66 A ATOM 2047 CB VAL A 268 -24.467 -2.736-54.696 1.0037.97 A ATOM 2048 CGl VAL A 268 -23.442-2.212-53.711 1.0037.95 A ATOM- 2049 CG2 VAL A 268 -25.369 -3.766-54:045 1.0037.31 A

ATOM 2050 C VAL A 268 -26.330 -2.146-56.215 1.0038.36 A

ATOM 2051 O VAL A 268 -25.974 -2.592.-57.3071.0038.33 A ATOM 2052 N VALA269 -27.593 -2.149-55.803 1.0038.86 A

ATOM 2053^; CA VAL A 269 -28.654 -2,684-56.641 1.0038.82 A

ATOM 2054 CB VAL A 269 -30.042 -2.154 -56.201 1.0039.78 A ATOM 2055 CGl VAL A 269 -30.210 -0.693-56.603 1.0039.00- A ATOM 2056 CG2 VAL A 269 -31.131 -3.012-56.791 1.0039.77 A ATOM 2057 C VAL A 269 -28.337 -2.238 -58.0581.0038-.65 A

ATOM 26580 VAL A- 269 -28.244-1.038-58.341 1.0037.65 A

ATOM 2-059 N PRO A 270 -28.118 -3.204-58.962 1.0038.9T A

ATOM 2060.CD PRO A 270 -28.178r -4.663 -58.7681.0038.79 A

ATOM 206-1 CArPRO A- 270 -27.79-9 -2.877-60353 1.00=40,29 A ATOM 2.062 CB-PRO A 270- -27.515 -4.249--=60.9-721.0039.11 A

-ATOM 2063 CG PRO-A 270 -28.369 -5.168-68,-170-1.0035.81 A

ATOM 2064 C PRO A 270 -28.908- -27106 -617062 1.0041,49 A

ATOM 2065 O PRO A 270 -28.719 -0:956-61.460 1.0041.44 A

ATOM 2066 N PHE A 271 -30.069 -2.730 -6L2121.0042.78 A ATOM 2067 CA PHE A 271 -31.17& -2.058 -61.8671.0044.21 A

ATOM 2068 CB PHE A 271 -31.867 -3.009-62.8491.0042.92 A

ATOM 2069 CG PHE A 271 -30.912 -3.723-63.751 1.0041.12 A

ATOM 2070 CDl PHE A 271 -30.601 -5.058-63.5341.0040.15 A

ATOM 2071 CD2PHEA271 -30.254 -3.037-64.7641.0040.09 A ATOM 2072 CEl PHE A 271 -29.644 -5.698-64.3061.0038.68 A

ATOM 2073 CE2PHEA271 -29.295 -3.670-65.5371.0039.16 A

ATOM 2074 CZ PHE A 271 -28.989 -5.001-65.308 1.0038.53 A

ATOM 2075 C PHE A 271 -32.173 -1.538-60.842 1.0045.89 A ATOM 2076 O PHE A 271 -33.L05 -2.245-60.440 1.0045.83 A

ATOM 2077 N PRO A 272 -31.970 -0.294-60.385 1.0047.80 A

ATOM 2078 CD PRO A 272 -30.896 0.647-60.749 1.0048.15 A

ATOM 2079 CA PRO A 272 -32.873 0.301-59.401 1.0050.23 A

ATOM 2080 CB PRO A 272 -32.075 1.492 -58.379 1.0049.47 A ATOM 2081 CG PRO A 272 -31.368 1.959-60.1121.0048.82 A

ATOM 2082 C PRO A 272 -34.122 0.720-60.1501.0052.22 A

ATOM 2083 O PROA-272 -34.341 0.295-61.2861.0052.31 A

ATOM 2084 N ALA A 273 -34.942 1.548-59.521 1.0054.74 A

ATOM 2085 CA ALAA273 -36.164 2.01S -60.161 1.0056.86 A ATOM 2086 CB ALA A 273 -35.815 .2.812-61.4121.0055.84 A

ATOM 2087 C ALA A 273 -37.125 0.877-60.5111.0058.05 A

ATOM 2088 O ALA A 273 -38.063 1.061-61.283 1.0058.13 A

ATOM 2089 N LYS A 274 -36.884 -0.301-59.951 1.0059.52 A

ATOM 2090 CA LYS A 274 -37.753 -1.447-60.193 1.0061.70 A ATOM -2091 CB LYS A 274 -36.970 -2.585-60.8571.0060.88 A

ATOM 2092 CG LYS A 274 -36.759 -2.393-62.3501.0060.36 A

ATOM 2093 CDLYSA-274 -3&957 -3.712-63.1040,00-60.48 A

ATOM 2094 CE LYS A 274 -37.019 -3-503-64.6140.0060.41 A

ATOM 2095- NZ-LYS-A 274 -37.528 -4.705--653380.0060.42 A ATOM^" 2096 C LYS A 274 -38.320 -1.890=58.844-1.0.0:63.31 A

ATOM 2097^"O LYS A 274 -37.S85 -1.392 -57.806- 1.0063.81 A

ATOM 2098 N PROA 275 -39.297 -2.816-58.837 l.OJQ 64.43 A

ATOM 2099 CD PRO A 275 -39.761 -3.706-59.9121.0064.39 A

ATOM 2100 CA -PRO A 275 -39.844 -3.240-57.5471.0065.58 A ATOM 2101 CB PRO A 275 -40.770 -4.397-57.9281.0065.03 A

ATOM 2102 CGPROA275 -40.115 -4.953-59.1441.0064.73 A

ATOM 2103 C PRO A 275 -38.702 -3.648-56.6221.0066.82 A

ATOM 2104 O PRO A 275 -37.758 -4.312-57.055 1.0067.23 A

ATOM 2105 N ALAA276 -38.794 -3.205-55.365 1.0067.48 A ATOM 2106 CA ALA A 276 -37.801 -3.481-54.323 1.0067.41 A

ATOM 2107 CB ALA A 276 -37.913 -2.428 -53.2221.0067.05 A

ATOM 2108 C ALA A 276 -37.909 -4.858-53.7171.0067.65 A

ATOM 2109 O ALA A 276 -18.947 -5.233-53.1541.0067.95 A ATOM 2110 N LEU A 277 -36.818 -5.604-53.8301.0067.8Q A

ATOM 2111 CA LEU A 277 -36.797 -6.920-53.2541.0068.17 A

ATOM 2112 CB LEU A 277 -35.779 -7.832-53.941 1.0067.17 A

ATOM 2113 CG LEUA277 -36.163 -8.313-55.329 1.0066.16 A

ATOM 2114 CDl LEU A 277 -35.070 -9.187-55.8761.0065.35 A ATOM 2115 CD2 LEU A 277 -37.467 -9.084-55.2541.0066.44 A

ATOM 2116 C LEUA277 -36.514 -6.895-51.780 1.0069.26 A

ATOM 2117 O LEU A 277 -3-5.745 -7.668. -51.294- 1.0069.-99 A

ATOM 2118 N ALAA278 -37.163 -5.977-51.070 1.0070.15 A

ATOM 2119 CA ALA A 27.8 -36.895 -5J83 -49.649 1.0070.63 A ATOM 2120 CB ALA A 278 -35.790 -4.756-49.453 1.0071.03 A

ATOM 2121 C ALA A 278 -38.217 -5.392-48.996 1.0070.67 A

ATOM 21220 ALA A 278 -38.502 -4.209-48.809 LOO 70.21 A

ATOM 2123 N VAL A 279 -39.020 -6.393 -48.651 1.0070.77 A

ATOM 2124 CA VAL A 279 -39.983 -6.264-47.564 1.0071.08 A ATOM 2125 CB VAL A 279 -40J58 -7.455-47.578 1.0071.10 A

ATOM ,2126 CGl VAL A 279 -42.372 -6.991-47.2661.0072.13 A

ATOM 2127 GG2 VAL A 279- -40.907 -8:7-169 -48,920. LOG 70:47 A

ATOM 2128 C VAL A 279 -39.088 -6305-46.330 hθO 71.02 A

ATOM 2129 O VAL-A^"27.9 -39.227 -7-±8θ-45.4791.0072.30- A- ATOM 2130 N ALAA 280 -38:169 -5348-46.2391.0070.06 A

ATΘM 2131 CA- ALAA 28O -37.737 -4.822 -44.950 -1.0068.32 A

ATOM 2132 CB ALA A 280- -36.325 -4 J272 -45:089 1.0068.95 A

ATOM 2133 C ALA A 2SO -38.708 -3.709-44.571 1.0.0.67.16 A

ATOM 2134 O ALAA 280 -38.659 -3.181-43.4601.0066.59 A ATOM 2135 N ALA A 281 -39.590 -3.358-45.501 1.0066.09 A

ATOM 2136 CA ALA A 281 -40.281 -2.075-45.456 1.0065.12 A

ATOM 2137 CB ALA A 281 -39.995 -1.274-46.718 1.0064.98 A

ATOM 2138 C ALA A 281 -41.783 -2.264-45.273 1.0064.22 A

ATOM 2139 O ALA A 281 -42.434 -1.494-44.5671.0064.24 A ATOM 2140 N THR A 282 -42.327 -3.294-45.9121.0063.53 A

ATOM 2141 CA THR A 282 -43.767 -3.524-45.909 1.0063.07 A

ATOM 2142 CB THR A 282 -44.246 -3.963-47.305 1.0062.85 A

AT-OM 2143 OGl THR A 282 -45.663 -3.774.-47.408 1.0062.73 A ATOM 2144 CG2 THRA 282 -44.080 -5.465-47.4781.0062.18 A

ATOM 2145X THR A 282 -44.156 -4.570-44.8691.0062.61 A

ATOM 2146 O THR A 282 -45.330 -4.912-44.7291.0062.54 A

ATOM 2147 N MET A 283 -43.163 -5.073-44.143 1.0062.00 A

ATOM 2148 CA MET A 283 -43.413 -5.925-43.002 1.0061.58 A ATOM 2149 CB MET A 283 -42.120 -6.611-42.5391.0061.02 A

ATOM 21-50 CG MET A 283 -41.758 -7.831-43.3471.0060.60 A

ATOM 2151 SD META 283 -40.167 -8.532 -42:916 -1.00-62.72 A

ATOM 2152 CE MET A 283 -40.620 -9.894-42.0221.0060.84 A

ATOM 2153 C META 283 -43.905 -4.922-41.962 LOO 62.01 A ATOM ^"2154 O META 283 -44.897 -5.166-4-1.283 1.0061.88 A

ATOM 2155 N LEU A 284 -43.238 -3.770-41.8861.0062.02 A

ATOM 2156 CA LEU A 284 -43.609 -2.727-40.9221.0062.14 A

ATOM 2157 CB LEU A 284 -42-559 -1.604-40.901 1.00-62.07 A

ATOM 2158 CG LEU A 284 -41.125 -2.030-40.5691.0062.52 A ATOM 2159 CDl LEU A 284 -40.155 -0.906-40.901 1.0062.17 A

ATOM 2*6Θ CD2LEUA284 -4JLΘ32 -2.429-39.1041.00-62.47^" A

ATOM 2161 C LEU A 284 -44.959 -^"2.133 -4L298 LOG 62.37 A ATOM 2162 O XEUA284 -45.836 -1.963-40.4621.0062.08 A

ATOM 2163 N- ALA A 2S5r- -45J12 -1,821-42.573.1:0063-66 A=.. ATOM 2464 CA ALA A 285 -46.348 -1.226-43.068 l.OO^" 64.73 A

ATOM 2165-C-B ALAA-285 -46.346-1.266-44.5761:00-65.56 A

ATOM 2166 -C ALA A 285 -47.636 -1.858 -42.5781. GO 64.63 A

ATOM 21670 AL-A A 285 -48.594 -1.198-42.181 1.0065.34 A

ATOM 2168 N GLN A 286 -47.623 -3.159-42.736 1.0063.84 A ATOM 2169 CA GLN A 286 -48.727 -4.008.-42.4081.0063.06 A

ATOM 2170 CB GLN A 286 -48.426 -5.395-42.9641.0063.44 A

ATOM 2171 CG GLN A 286 -49.157 -5.677-44.2721.0063.13 A

ATOM 2172 CD GLN A 286 -48.768 -7.008-44.875 1.0063.26 A

ATOM 2173 OEl GLN A 286 -47.634 -7.187-45.3261.0063.46 A _ΛΛ,

445

ATOM 2174 NE2 GLN A 286 -49.704 -7.957-44.883 1.0061.94 A

ATOM 2175 C GLN A 286 -49.275 -4.135-40.9921.0061.98 A

ATOM 2176 O GLN A 286 -50.373 -3.688-40.7051.0062.38 A

ATOM 2177 N GLYA287 -48.481 -4.685-40,0951.0060.83 A ATOM 2178 CA-GLYA-287 -48.983 -4.909-38.743 1.0058.57 A

ATOM 2179 € GLYA287 -48.31T -6.139-38.2091.0056.95 A

ATOM 2180 O GLY A 287 -48.982 -7.073-37.8391.0058.02 A

ATOM 2181 N TRP A 288 -46.997 -6.105-38.083 1.0055.03 A

ATOM 2182 CA TRP A 288 -46.272 -7.3-13-37.7031.0054.00 A ATOM 2183 CB TRPA 288 -45.270 -7.563-38.8221.0055.41 A

ATOM 2184 CG TRP A 2SS^~ -45.840 -8-13T-40.114- 1.0056.31 A

ATOM 2185 -CD2 TRP A 288 -45.348 -9.301 -40.7801.0056.09 A

ATOM 2186 CE2 TRP A 288 -46.160 -9.523-41.915 1.0055.39 A

ATOM 2187 CE3 TRP AJ288- -44.291--10.186 -40.5191.0055.20 A ATOM 2188 CDl TRP A 288 -46.919- -77685 -40.8661.0056.64 A

ATOM 2189 NEl TRPA 288 -47.108 -.8.529 -41.9521.0056.13 A

ATOM 2190 CZ2TRPA288 -45.944-10.602-42.782 1.0054.04 A

ATOM 2191 CZ3TRPA288 -44.077-11.256-41.383 1.0053.80 A

ATOM 2192 CH2 TRP A 288 -44:901 -11.454-42.498 1.0053.63 A ATOM 2193 C TRP A 288 -45.534 -7.632-36.385 1.0052.82 A

ATOM 2194-0 TRP A 288 -44345 -7.341-36.245 1.005L95 A

ATOM 2195 N ALAA ^"28S- -46.192 -8.3.47 -35.483 1.005L84 A

ATOM 2196 CA AiLA A 2.89 -45.568 -8.746 -34.2301.0050.52 A

ATOM 2197 CB ALAA-289 -46.523 -9.553-33.381 LOO 49-73 A ATOM 2198 C AEAA^"289 -44.402 ^9:608,-34,5941.00-49.77 A-

ATOM 21-99-0 ALAA 289 -44.323 -10.1-68 -35.680-1.00-50.05 A

ATOM^" 2200 N- AEAA29-0 -4-3.506 -^~9.7Θ1 -33.6361.00-49.14 A

ATOM 2201 CA ALA A290 -42.318.-10.498.-33.7541.0049.56 A

ATOM 2202 CB ALA A 290 -41.448-10,259-32.541 1.0049.67 A ATOM 2203 C ALA A 290 -42.822-11.934-33.7761.0050.08 A

ATOM 2204 O ALA A 290 -42.132-12.852-34.2201.0049.03 A

ATOM 2205 N ALA A 291 -44.043-12.123-33.2871.0051.48 A

ATOM 2206 CA ALA A 291 -44.639-13.456-33.2481.0053.44 A

ATOM 2207 CB ALA A 291 -45.812-13.498-32.241 1.0053.44 A ATOM 2208 C ALA A 291 -45.125-13.791-34.6441.0054.56 A

ATOM 2209 O ALA A 291 -44.933-14.909-35.1341.0054.51 A

ATOM 2210 N ALA A 292 -45.752-12.808-35.2841.0055.23 A

ATOM 22-11 CA ALA A 292 -46.255 -12.978^~-36.643 1.0054.71 A ATOM 2212 CB ALA A 292 -46.663-1-1,626-37:228 1.0054.98 A

ATOM 2213 C ALA A 292 -45.164-13.619-37.5.01 1.ΘΘ--54.61 A^"

ATOM 2214 O ALA A 292 -45.448-14.429-38.3821.0054.62 A

ATOM 2215 N MET A 293 -43.913-13.258-37231 1.0054.50 A

ATOM 2216 CA MET A 293 -42.780-13.802-37.971 1.0053T68 A ATOM 2217 CB MET A 293 -41.496.-13.020 -37.645 1.0053.74 A

ATOM ^"2218 CG MET A 293 -41.403-11.699-38,3901.0054.17 A

ATOM 2219 SD MET A 293 -40.117-1-0.621-37.7791.0054.30 A

ATOM 2220 CE MET A 293 -38.651-11.619-38.1381.0054.28 A

ATOM 2221 C MET A 293 -42.579-15.289-37.700.1.0052.38 A ATOM 2222 O MET A 293 -42.333-16.062-38.618 1.0052.98 A

ATOM 2223 N PHE A 294 -42.703-15.705-36.451 1.0051.10 A

ATOM 2224 CA PHE A 294 -42.51S -17.117 -36.136^" 1.0050.54 A

ATOM 2225 CB PHE A 294 -42.286-17.294-34.632 LOO 46.42 A

ATOM 2226 CG PHE A 294 -40.921-16.876-34.1781.0041:80 A ATOM 2227 CDl PHE A 294 -40.599-15.525-34.0391.0039.61 A

ATOM 2228 CD2 PHE A294 -39.938 -17-1836 -.33.944.1,0038.96- A

ATOM 2229 CEl EHE A- 294 -39.312 -15.133 ^3.6771-0037.7S A-

ATOM 2230 CE2 EHE A 29.4 -38,650-17.461-33.58210037.57 A

ATOM 2231 CL PHE A 294 -38.335-16=101-33.74501.0037.56 A ATOM 2232 C PHE- A 294 -43.714.-17.964--3-6.573-1.0Θ 52.31 A^"

ATΘM.2233 O ^"PHE A 294 -43.71T-l-9.198=-3^463 1.0051.32 A-

ATOM 2234 N ARGA-295 -44:722 -17.262 -37τ078_L0054.14 A

ATOM 2235 CA ARGA 295 -45.983-17.844-37.531 1.0056.06 A

ATOM 2236 CB ARG A 295 -47.090 -16.863 -37.2321..0057.04 A- ATOM 2237 CG ARG A 295 -47.996-17.312-36.1521.0058.36 A

ATOM 2238 CD ARG A 295 -49.389-17.132-36.641 1.0059.09 A

ATOM 2239 NE ARG A 295 -49.449-16.397-37.903 1.0060.28 A

ATOM 2240 CZ ARG A 295 -50.494-16.457-38.7161.0061.09 A

ATOM 2241 NHl ARG A 295 -51.516-17.217-38.3671.0061.92 A ATOM 2242 NH2 ARG A 295 -50.530-15.770-39.853 1.0061.44 A

ATOM 2243 C ARG A 295 -46.043-18.184-39.015 1.0056.71 A

ATOM 2244 O ARG A 295 -46.727-19.136-39.4401.0058.07 A

ATOM 2245 N ALA A 296 -45.34d-17.35J -39.781 1.0055.75 A ATOM 2246 CA ALA A 296 -45.246-17.465-41.2L5 1.0054.il A ATOM 2247 CB ALA A 296 -44.855 -16.1T4 -41.802 1.0053.37 A

ATOM 2248 C ALAA296 -44.169-18.486-41.458 1.0053.81 A

ATOM 22490 ALA A 296 -44.298-19.345-42.313 1.0054.07 A

ATOM 2250 N ALA A 297^" -43.101-18.399-40.683 1.0053.71 A ATOM 2251 CA ALA A 297 -42.011-19.353-40.829 1.0053.97 A ATOM 2252 CB ALA-A297 -40.912-19.066-39:823 1.0053.80 A

ATOM 2253 C ALA A 297 -42.576-20.740-40.5781.0.054.45 A

ATOM 2254 O ALA A 297 -42.160-21.734-41.1801.0055.32 A

ATOM 2255 N GLU A 298 -43.497-20.785-39.6241.0054.57 A ATOM 2256 CA GLU A 298 -44.194-22.007-39.2371.0054.73 A ATOM 2257 CB GLU A 298 -45.348-21.685-38.2681.0055.90 A ATOM 2258 CG GLU A 298 -45.549-22.710-37.153 1.0056.36 A ATOM 2259 CD GLU A 298 -46.742-22.414-36.245 1.0056.12 A ATOM 2260 OEl GLU A 298 -47.135-21.229-36.1061.0056.21 A ATOM 2261 OE2 GLU A 298 -47.270-23.386-35.659 1.0056.33 A

ATOM 2262 C GLU A 298 -44.829-22.579-40.4691.0053.80 -A

ATOM 2263 O GLU A 298 -44.403-23.579-41.059 LOO 52.51 A

ATOM 2264 N GLU-A 299- -45.892-21.872 -40,8151.90-53.35 A ATOM 2265 CA GLU A 299 -M.741 -22rl78 -4109281.0053.42 A- ATOM 2266_CB GLUA-299 -47.552-20.964-42.303 1.0052.91 A ATOM 2267 CG GLU A 299 -47,625-20.900-43.7851.00-53.99^" A ATOM 2268 CD GLU A^~299 -4S-.649 -19.971 -44.3291.0053.83 A- ATOM 2269 OEl GLU A 299 -49.744-20.461-44,6891.00-53.15 A ATOM 2270 OE2 GLU A 299 -48.338 -18.763 -44.407 LOO 52.52 A ATOM 2271 C GLU A 299 -46.055-22.716-43.175 1.0053.34 A

ATOM 2272 O GLU A 299 -46.696-23.373-43.975 1.0053.78 A

ATOM 2273 N PHE A 300 -44.775-22.432-43.375 1.0052.75 A

ATOM 2274 CA PHE A 300 -44.101-22.974-44.553 1.0051.93 A

ATOM 2275 CB PHE A 300 -42.764-22.259-44.8161.0051.40 A ATOM 2276 CG PHE A 300 -42.042-22.728-46.073 1.0050.20 A

ATOM 2277 CDl PHE A 300 -42.154-22.051-47.273 1.0049.93 A

ATOM 2278 CD2 PHE A 300 -41.241-23.839-46.049 1.0049.69 A

ATOM 2279 CEl PHE A 300 -41.470-22.502-48.421 1.0049.21 A - ATOM 2280 CE2PHEA300 -40.566-24.264-47.206 1.0048.51 A

ATOM 2281 CZ PHE A 300 -4O.689 -23.602 -48.3701.004S.36 A

ATOM 2282 C PHE A 300 -43.851-24.413-44.1321.0051.60 A

ATOM 2283 O PHE A 300 -44.215-25.361-44.8241.0052.08 A

ATOM 2284 N PHE A 301 -43.^"228 -24.557 -42.9701.O050.92 A ATOM 2285 CA THE A 301 -42.950-25.878-42.4201.0049.53 A

ATOM 2286 CB PHE A 301 -42.416 -25.772 -4 LQ08 1.0046.59 A

ATOM 2287 CG PHE A 301 -40.955-25.552-40.9391.0044.44 A

ATOM 2288 CDl PHE A 301 -40.442-24.255-40.892 1.0043.44 A

.ATOM 2289 CD2 PHE A 301 -40,089-26.645-40.857 1.0043.68 A ATOM 2290 CEl PHE A301 -39.066-24.036-40.7571. OO 42.66 A

ATOM 2291 CE2PHEA301 -38.713-26.457-40.723 1.0042,96 A

ATOM 2292 CZ PHE A 301 -38.193 -25.146 -40.666 1.0042.26 A

ATOM 2293 C PHEA 301 -44.074-26.905-42.363 LOO 50.25 A

ATOM 22940 PHE A 301 -43.813-28.086-42.5571.0049.95 A ATOM 2295 N THR A 302 -45.282-26.470-42.0101.0051.11 A

ATOM 2296 CA THR A 302 -46.432-27368-41.949 1.0051.06 A

ATOM^" 2297 CB THRA 3€2 -47.713 -26.516-41.732 IM 50.04 A

ATOM 2298- OGl THR A.3Θ2 -47.837 ^25.477 -42.728-1.0049.68-. A

ATOM 2299 CG2THRA302^" -47.640-^"25r850 -40.3-55 1.00148.07 A ATOM 2390 C THR-A" 302 -46.583 -2&Ω50 -43τ2971=6052.02 A

ATOM 2301 O- THR A 302 -46387-29.249-43.471 1.QΘ-5&88- A

ATCM 2302 N ALAA 3Θ3 -46.917 -27..153 -44.204-1.0033.26- A

ATOM 2303 CA ALA A 303 -47.078-27.320-45.618 1.0053.74 A

ATOM 2304 CB ALA A 303 -46,743-26.000-46.165 1.0052.58 A ATOM 2305 C ALA A 303 -46.052-28.209-462821.0054.13 A

ATOM 2306 O ALAA303 -46.318-29.120-47.105 1.0055.05 A

ATOM 2307 N LEU A 304 -44.802-27.939-45.921 1.0055.08 A

ATOM 2308 CA LEU A 304 -43.752-28.952-45.945 1.0057.35 A

ATOM 2309 CB LEU A 304 -42.386-28.290-45.747 1.0057.82 A _44p

ATOM 2310 CG LEU A 304 -41.603-27.933-47.0121.0057.57 A

ATOM 2311 CDl LEU A 304 -41.555 -26.425- -47.205 1.0057.35 A

ATOM 2312 CD2 LEU A 304 -40.199 -28 JSU -46.953 1.0057.39 A

ATOM 2313 C LEU A 304 -43.986-29.993-44.855 1.0059.39 A ATOM 23140 LEU A 304 -43.107-30.252-44.033 1.0061.25 A

ATOM 2315 N ALA A 30i -45.174-30.589-44.855 LOO 60.04 A

ATOM 2316 CA ALA A 305 -45.322-31.999-44.5171.0060.56 A

ATOM 2317 CB ALAA 305 -44.836-32.873-45.663 1.0060.44 A

ATOM 2318 C ALA A 305 -44.57ST-32.343 -43.2301.0060.71 A ATOM 23190 ALA A 305 -44.236-33.502-42.991 1.0060.25 A

ATΘM 2320 N LEUA 306 -44.332-31.331-42.4051.0060.77 A

ATOM 2321 GA LEU A 306 -43.492-31.492-41.224 1.0060.47 A

ATOM 2322 CB LEU A 306 -42.125-30.841-41.4471.0059.93 A

ATOM 2323 CG LEU A 306 -41.152-31.597-42.353 1.00-59.35 A ATOM- 2324 CDl LEU AJ306 -39.778 -30.947 -42 J271.0059 J 1 A

ATOM 2325 CD2LEUA306 -41.065-33.060-41.9461.0058.36 A

ATOM 2326 C LEU A 3 Off -44.159 -30.900-39.9871.00 J50.54 A-

ATOM 2327 O LEU A 306 -45.039-30.046-40.0951.0060.62 A

ATOM 2328 N SERA3Θ7 -43.735-31.357-38.8131.0060.01 A ATOM 2329 CA SER A 307 -44.370-30.952-37.5621:0059.66 A

ATOM 2330 CB SERA 307 -43.881-31.781-36.3901.0058.82 A

ATOM 2331 OG -SER A 3:07 -42.484-31.879-36.373 1.00-6K41 A

A^OM 2332 C SERA 307 -44.290 -29.478 -37.ZL91.00-60.13 A.

AT-QM 2333 O SERA3J3.7 -43.305-28.788-37.511 1:0060,54- A ATOM 2334 N PRO A 3GS -45.371 -28.954-~3_6J624 kθO 60:9Q- A

-ATOM 2335 CD PROA 308 -46:644-29:643 -36=3371.006L08 A

ATOM 2336 CA PRO A 308 -4*4*9 -27.544 -36.2321.006.1.23 A

ATOM 2337 CB PRO A 308 -46.947 -27.283 -36.201 1.0061.05 A

ATOM 2338 CG PRO A 308 -47.462-28.561-35.6141.006-1,35 A ATOM 2339 C PRO A 308 -44.802-27.335-34.8781.0.061.35 A

ATOM 2340 O PRO A 308 -44.363-28.288-34.238 1.0061.43 A

ATOM 2341 N MET A 309 -44.741-26.089-34.4391.0061.55 A

ATOM 2342 CA MET A 309 -44.125-25.816-33.1561.0062.70 A

ATOM 2343 CB MET A 309 -43.882-24.315-32.998 1.0061.81 A _45Q

ATOM 2344 CG MET A 309 -42.787-23.784-33.905 1.0061.31 A

ATOM 2345 SD MET A 309 -41.213-24.695-33.7091.0060.49 A

ATOM 2346 CE MET A 309 -4.1.169-25.656-35.2371.0062.73 A

ATOM 2347 C MET A 309 -45.012-26.325-32.035 1.0063.82 A ATOM 23480 MET A 309 -46.209-26.018 -32.Q05 1.0064.25 A

ATOM 2349 N PROA310 -44.441-27.123-31.101 1.0064.49 A

ATOM 2350 CD PRO A 310 -43.035-27.554-31.0391.0064.10 A

ATOM 2351 CA PROA 310 -45.196-27.674-29.9661.0065.02 A

ATOM 2352 CB^" "PRO A 310 -44.160-28.528-29.231 1.0063.73^" A ATOM 2353 CG PRO A 310 -43.146-28.851-30.281 1.0063.64 A

ATOM 2354 C PRO A 3 It) -4-5.704--26.532 -29.080 l.OQ 65.87 A

ATOM 2355 O PRO A 310 -45.251 -25.356 -29.203 1.0066.83. A

ATOM 2356 N PROA311 -46.668-26.818-28.1921.0065.74 A

ATOM 2357 CD PRO A 311 -47.631 -27.932 -28.202.1.0065.24 A ATOM 2358 CA PRO A 311 -47.144-25.721-27.3421.0064.84 A

ATOM 2359 CB PRO A 311 -48,366-26.326-26.6641.0064.51 A

ATOM 2360 CG PROA 311 -48.894-27.251 -27.7391.0064.93 A

ATOM 2361 C PROA 311 -46.055-25.276-26.353 1.0064.31 A

ATOM 2362 O PRO A 311 -45.933-24.089-26.0461.0063.30 A ATOM 2363 N GLU A 312 -45.258-26.228,25.8701.0063.75 A

ATOM 2364 CA GLU A 312 -44.174-25.909-24.942 1.0063.85 A

ATOM 2365- CB GLUA 312 -43.320-27.156-24.681 1.0063.97 A

ATOM 2366 CG GLU AJ 12 -44.05S -28.257 -23.948 LOO 64.38 A

ATOM 2367- CD-GLU A 312 -43.664-29.631-24,4241700-64.65 A ATOM .2368 OEl GLU A 312 -43.738-29.859-25.651 1.0064.73- A

A-TQM 236-9 ΘE2 GCU A 3.12 -43.281 -_3θ;482 -23-.S86 LOO 64.70 A

ATOM 2370 C T3LU A 312 -43.281-24.807-25.524 J-OO 63.69 A

ATOM 2371 O GLUA 312 -42.895-23.870-24.8291.0063.43 A

ATOM 2372 N PHE A 313 -42.963-24.943-26.8091.0063.76 A ATOM 2373 CA PHE A 313 -42.102-24.010-27.5241.0062.95 A

ATOM 2374 CB PHEA 313 -41.945-24.435-28.9861.0062.33 A

ATOM 2375 CG PHEA 313 -41.440-23.322-29.9021.0061.72 A

ATOM 2376 CDl PHE A 313 -40.075-23.102-30.0451.0060.62 A

ATOM 2377 CD2 PHE A 313 -42.329 -22.490 -30.6101.0061.57 A ATOM 2378 CEl PHE A 313 -39.592-22.089-30.8671.0060.29 A ATOM 2379 CE2 PHE A 313 -41.846-21.462-31.4421.0060.90 A

ATOM 2380 CZ PHEA 313 -40.474-21.269-31.5661.0060,80 A

ATOM 2381 C PHE A 317 -42.709-22.650-27.5501.00:63.19 A ATOM 23820 PHEA3T3 -42.053-21.642-27.371 1.0063.66 A

ATOM 2383 N- TRP^~A 314 -43.977 -22:643 -27.8871.0063.42 A

ATOM 2384 CA TRP A 314 -44.669-21.397-27.9881.0064.35 A

ATOM 2385 CB TRP A 314 -46.074-21.650-28.4661.0065.76 A

ATOM 2386 GG TKP A 3-14 -46.346 -21.2T)Q- -29.8791.0066.86 A ATOM 2387 CD2TRPA314 -47.322-20.236-30,253 1.00-67.19 A

ATOM 2388-CE2 TRPlA 314 -47.335-20:213-31.6691.00-67.38- A ATOM 2389 CE3 TRP A 314 -48.163-19.388-29.521 1.0066.82 A ATOM 2390 CDl TRP A 314 -45.834-21.714-31.058 1.0067.31 A ATOM 2391 NEl TRP A 314 -46.469-21.122-32.1401.0067.27 A ATOM- 2392 CZ2 TRPA Jl 4 -48.268-19.370-32.361 1.0067.66 A ATOM 2393 CZ3 TRP-A 314 -49.036-18.553-30.203 1.0066.99 A ATOM 2394 CH2 TRP A 314 -49.085 -18.550 -31.6101.0067.34 A

ATOM 2395 C TRPA 314 -44.690-20.573-26.7191.0064.38 A

ATOM 23960 TRP A 314 -44.940-19.365-26.746 1.0064.26 A ATOM 2397 N ALAA 315 -44.413-21.20,7-25.595 1.0064.36 A ATOM 2358. CA AhA A 315 -44.422-20.447-24.3671.0064.15 A ATOM 2399- CB ALAA-315 -45.626-20.825-23.3261JOLO.63.43 A

ATΘM- 2400L C ALA A 315 -43.1-f8 -20.600 -23.603 LΘΘ-64.17 A

ATOM- 2401 O ALA A 315 -42.73Θ-19.703--22.8821.00-64.36 A ATOM 2402 N GLY A 316, -42.431-21:722-23.732 1.0063.88 A ATOM 2403 CA GLY A 316- -41.155 -21V779 -23.Θ42.1.00-63.93 A

ATOM- 2.404 C GLY A 316- -40.219--2bO41 -23.993 1.0064.03 A

ATOM 2405 O GLY A 316 -39.084 -2L435 -24.156 LOQ 62.87 A

ATOM 2406 N SERA 317 -40.710-19.999-24.669 l.QO 64.29 A ATOM 2407 CA SERA 317 -39,873 -19.279 -25.657 LQO 64.86 A

ATOM 2408 CB SERA 317 -40.369-19.584-27.0821.0064.59 A

ATOM 2409 OG SERA 317 -39.773-20.755-27.5971.0063.06 A

ATOM 2410 C SERA 317 -39.699-17.754-25.5781.0065.60 A

ATOM 2411 O SERA 317 -40.639-17.025-25.2491.0065.85 A ATOM 2412 N META 318 -38.509-17.254-25.9071.0065.97 A

ATOM 2413 CA MET A 318 -38.304-15.814-25.859 1.0066.30 A

ATOM 2414 CB META 318 -37.126-15.466-24.961 1.0067.20 A

ATOM 2415 CG META 318 -37.055 -13.990 -24.611 1.00-68.80 A ATOM 2416 SD META 318- -35.434-1-3.558-23.971 1.0071.05 A

ATOM 2417 CE MET A 318. -34.479 -13^.605 -25.4961.0071.30 A

ATOM 2418 C META 318 -38.058-15.302-27.263 1.0066.10 A

ATOM 2419 O META 318 -36.969-15.475-27.821 1.0066.87 A

ATOM 2420 N LEUA 319 -39=077 -14:662 -^"27.825 1,0065.61 A ATOM 2421 CA LEU A 319 -38.978 -14-.148 -29.173 1.00-65.34 A

ATOM 2422 CB EEUA 319- -40.147 -14.673-3O;M8 ITOO 63.93 A

ATOM 2423 CG LEU A319 -40.544-16.122 -29.703 1.0062.28 A

ATOM 2424 CDl LEU A 319 -41.715-16.493-30.5801.0061.58 A

ATOM 2425 CD2LEUA319 -39382-17.074-29.9241.0061.30 A ATOM 2426 C LEU A 319 -38.88G -12.62829.290 1.00-65.75 A

ATOM 24270 LEUA 319 -38.960-12.106-30.3871.0067.28 A

ATOM 2428 N GLU A 320 -38.713 -11.926-28.173 1.0065.39 A

ATOM 2429 CA GLU A 320 -38.547-10.475-28.192 1.0065.21 A

ATOM 2430 CB GLU A 320 -39.893 -9.751-27.965 1.0064.61 A ATOM 2431 CG GLUA 320 -41.075-10.243-28.803 1.0065.93 A

ATOM.2432 CD GLU A 320 -42.239 -9.249 -2-S:8371.0067.4« A

ATOM 2433 OEl GLU A 320 -43.404 -9.707^8.858-1.0068.04 A

ATOM 2424 ΘE2GLUA32C- —41.986 -8.022-28.859100-68.51 A

-ATOM 2435 C GLUA.320 -17.568-10.104-27.0801.0065.11 A ATOM 2436 O GLU A 320 -37.417 -10.846 -26. KS2^" 1.0065.73 A

ATOM 2437 N- ALAA-321 -36.868 -8.977 -27.23-t 1.0:0-64:52 A

ATOM 243S-CA ALA A 321 -35.942 -8.539-26.175 -1.0063.43 A

ATOM 2439 CB- ALA A 321 -35τO65 -7359-26.655 L0S-63.59 A

ATOM 2440 C ALA A 321 -36.920 -8.107 -25.091- 1.0062.68 A ATOM 2441 O ALA A 321 -37.637 -7.128-25.261 1.0062.43 A

ATOM 2442 N PRO A 322 -36.955 -8.859-23.9671.0061.91 A

ATOM 2443 CD PRO A 322 -35.895 -9.817-23.6181.0061.69 A

ATOM 2444 CA PRO A 322 -37.820 -8.630-22.813 1.0061.45 A

ATOM 2445 CB PRO A 322 -37.220 -9.519-21.7441.0061.21 A ATOM 2446 CG PRO A 322 -36.564-10.608-22.5141.0061.05 A

ATOM 2447 C PRO A 322 -37.955 -7.186-22.3621.0061.68 A

ATOM 2448 O PRO A 322 -37.197 -6.275-22.7321.0061.87 A

ATOM 2449 N ALA A 323. -38.919 -7.002-21.4861.0062.11 A ATOM 2450 CA ALA A 323 -39-220 -5.669-21.018-1:0062.69 A

ATOM 2451 CB ALA A 323 -40.680 -5.406-21.291 LOO 62.20 A-

ATOM 2452 C ALA A 323 -38.878 -5.321-19.571 1.0063.10 A

ATOM 2453 O ALA A 323 -38.778 -4.136-19.2161.0063.19 A

ATOM 2454 N ALA A 324 -38.691 -6.356-18.7571.0063.13 A ATOM 2455 CA ALA A 324 -38355 -6.235-17.3481.0062.56 A

ATOM 2456 CB ALA A 324 -38.487 -7.606-16.6891.0061.68 A

ATOM 2457 C ALA A 324 -36.933 -5...705- -17.213 LOO 62.44 A

ATOM 2458 O ALA A 324 -36.423 -5.540-16.103 1.0062.54 A

ATOM 2459 N GLY A 325 -36.319 -5.456-18.372 1.006232. A ATOM 2460 CA GLY A325 -34.960 -4.925-18.4761.0061.-93 A

ATOM 2461 C -GLY A 325 -33:816 -.5.902-18.241 1.0061.67 A

ATOM 2462 O GLY A 325 -32.634 -5.546-18.1571.0061.51 A

ATOM 2463 N ARG A 326 -34.197 -7.155-18.118 1.0060.95 A

ATOM 2464 CA ARG A 326 -33.280 -8.237-17.8191.0060.91 A ATOM 2465 CB ARG A 326 -34.133 -9.464-17.5501.0060.76 A

ATOM 2466 CG ARG A 326 -35.603 -9.106-17.2-191.00.59.93 A

ATOM 246T CD- ARG A 326 -36.580-10,017-17.9601.0058:98- A

ATOM 2468 NE ARG A 326 -36.0.61 -11.3SQ-18.0571.00-59.17 A

ATOM 2469 CZ_ARGA326 -33351 -12307 -18^8741.0U59:84 A - ATOM -24-70-NHlARG A 326 -37.580-12.016-19.663 1:00-60:47 A

ATOM 2471 NH2 ARG A 326 -3.5.995 -13.513^~18:9221,0059.22 A

ATOM^" 2472 C ARG A 326 -32.176 -8.568 -18.8501XKT61.38 A

ATOM 2473 O ARG A 326 -32.346- -9.412 -19.7501.0062.5^ A

ATOM 2474 N ALAA327 -31.012 -7.-953-18.6651.0060.81 A ATOM 2475 CA ALA A 327 -29.856 -8.181 -19.5411.0Q60.57 A

ATOM 2476 CB ALA A 327 -28.566 -7.869-18.8091.0060.13 A

ATOM 2477 C ALA A 327 -29.811 -9.609-20.0721.0050.61 A

ATOM 2478 O ALA A 327 -29.598-10.586-19.3471.0060.21 A

ATOM 2479 N VAL A 328 -29.990 -9.724-21.371 1.0060.02 A ATOM 2480 CA VAL A 328 -29.989-11.035-21.958 1.0059.38 A

ATOM 2481 CB VALA328 -31.452-11.407-22.3541.0059.17 A

ATOM 2482 CGl VAL A 328 -32.265-10.132-22.5801.0058.46 A

ATOM 2483 CG2 VAL A 328 -31.471-12.239-23.6181.0058.92 A ATOM 2484 C VAL A 328 -29:031-11.162-23.131 1.0058.86 A

ATOM 2485 O TAL A 328 -28.559-10.177-23/698 1.0059.98 A

ATOM 2486 N VAL A 329 -28.741-12.408-23.4601.0057.56 A

ATOM 2487 CA VAL A 329 -27.877-12.752-24.5641.0056.70 A

ATOM 2488 CB VAL A 329 -27392T-14.158 -24.373 1.0056.52 A ATOM 2489 CGl VAL A 329 -26.719-14.653-25.6141.0056.17 A

ATOM 2490 CG2 VAL A 329 =26.472 -14.194 -23.1971.0056.87 A

ATOM 2491 C VAL A 329 -28.753-12.670-25.7891.0056.40 A.

ATOM 2492 O VAL A 329 -29.367-13.645-26.198 1.0056.24 A

ATOM 2493 N CYS A 330 -28.817-11.474-26.349 1.0055.16 A ATOM 2494 CA CYS A 330 -29.684 -11.210 -27.4771.0054.04 A

ATOM 2495 C CYS A 330 -29.545-12.039-28.746 1.0054.64 A

ATOM 2496 Q CYS A 330 -30.462 -12^046 -29.578 1.0055.49 A

ATOM 2497 CB CYS A 330 -29.626 -9.735-27.8141.0053.81 A

ATOM 2498 SG CYS A 330 -31.019 -8.841-27.067 1.0054.73 A ATOM 2499- N HISA 331 -28.439-12.761-28.885 1.0053.95 A

ATOM 2500 CA HIS A 331 -28.199 -13.591 -30.055 1.0052L78 A

ATOM 2501 CB HISA-331 -26.972 -14.446 -29.80S 1.0052-24 _A

ATOM -2502-GG HISA-331 --26.136-14.643 -3hO25 1.00-52.77 A

ATOMr 2503- CD2 HIS A 331 -25.227 -15-594 -31.329" 1.0052745- A ATOM 2504 NDl-HIS AJ31 -26J074-13.717 -32.043 LOG- 53.04 A

ATOM 2505 CElHIS A 331 -25.146 -MΛM.-32.9111.00-51.94 A

ATOM 2506 NE2 HIS A 331 -247613-137216-32.498 1.0052.05 A

ATOM- 2507 C HIS A 331 -29.3^"83 -14.494-30.3391.0052.07 A

ATOM 2508 O HIS A 331 -30.188-14.752-29.4551.0052.14 A ATOM 2509. N ALA A 332 -29.489-14.-968-31.572 1.0051.il A

ATOM 2510 CA ALA A 332 -30.564-15.876-31.924 1.0050.02 A

ATOM 2511 CB ALA A 332 -30.987-15.662-33.358 1.0051.10 A

ATOM 2512 C ALA A 332 -29.971-17.256-31.7591.0049.75 A

ATOM 2513 O ALA A 332 -28.854-17.487-32.1981.0049.73 A ATOM 2514 N SERA 333 -30.697-18.157-31.103 1.0049.26 A

ATOM 2515 CA SERA 333 -30.221-19.532-30.9071.0049.40 A

ATOM 2516 CB SER A 333 -29.247-19.622-29.722 1.0049.55 A

ATOM 2517 OG SERA 333 -29.827-19.080-28.5471.0049.70 A ATOM.2518 C SERA 333 -31.409-20.461-30=6761.0049.30 A

ATOM 2519 O SERA 333 -32.515-20.001-30.3741.0049.35 A

ATOM 2520 N ALA A 334 -31.178-21.763-30.830 1.0048.89 A

ATOM 2521 CA ALA A 334 -32.229-22.761-30.646 1.0048.44 A

ATOM 2522 CB ALA A 334 -32.496 -23.4m -31.9501.0049.71 A ATOM 2523 C ALA A 534 -31.826-23.759-29.570 l.OQ 48.53 A

ATOM 2524 O ALA A 334 -30.696 -24.264 -29.5561.0046.89 A

ATOM 2525 N TRP A 335- -32.773 -24.067 -28.6901.0049.09 A

ATOM 2526 CA TRP A 335 -32.504-24.957-27.571 1.0050.20 A

ATOM 2527 CB TRP A 335 -32.837-24.224-26.2741.0051.73 A ATOM 2528 CG TRPA 335 -3Z109 -22.925 -26.133 1.0053.89 A

ATOM 2529^" CD2 TRP A 335 -3-1.176-22.573-25.1091.0054.86 A

ATOM 2530 CE2 TRP A 335 -30.713 -2L271 -25.3961.0055.65 A

ATOM 2531 CE3TRPA335 -30.682-23.23-1-23.979 1.0055.19 A

ATOM 2532 CDl TRP A 335 -32.178 -21.848 -26.9761.0054.87 A ATOM 2533 NEl TRP A 335 -31.340-20.851-26.5401.0055.45 A

ATOM 2534 CZ2 TJRP A 335 -29.780-20.618 -24.590- 1.0055.68 A

ATOM 2535 -CZ3 TRP A 335- -29.754-22.5-78 -23, L82 MW55.49 -A

ATOM 2536 CH2 TRPA 335 -29-314 -2-1 J2S7 -23.492 1.00^54.87 A

ATΘM_^537-C TRP A 335 -33.179 -26.319-27356 -1.0049.89- A ATOM 2538 £> TRP A 335 -31.389-26.436 -27.7391.0048τ99 A

ATOM^; 2539 N ASP A336 -32371 -27.343.~27.3O81.0049.85 A-

ATOM- 2540 CA- ASP A 336 -32.838-28.717-27.2191,00-51707 A

ATOM 2541 CB ASP A 336 -32.044-29.591-28.194 1.0050.80 A

ATOM 2542. CG ASP A 336 -32.565-31.011 -28.274 1.0050.56 A ATOM 2543 ODl ASP A 336 -33.771-31.217-28.0061.0050.32 A-

ATOM 2544 OD2 ASP A 336 -31.768-31.910-28.6281.0050.44 A

ATOM 2545 C ASP A 336 -32.592-29.153-25.763 1.0052.72 A

ATOM 2546 O ASP A 336 -31.440-29.325-25.3391.0052.58 A

ATOM 2547 N PHE A 337 -33.676-29.317-25.004 1.0053.17 A ATOM 2548 CA PHE A 337 -33.584-29.707-23.602 1.0053.65 A

ATOM 2549 CB PHE A 337 -34.814-29.220-22.835 1.0053.27 A

ATOM 2550 CG PHE A 337 -34.818-27.744-22.553 1.0053.41 A ATOM 2551 CDl PHE A 337 -35.135-26.827-23.551 1.0053.47 A ATOM 2552 CD2 PHE A 337 -34.549-27.272 -21.272 LOO 52.98 A ATOM 2553 CEl PHE A 337 -35.194-25.457-23.273 1.0052.75 A ATOM 2554 CE2PHEA337 -34.605-25.912-20.988 1.0052.76 A

ATOM 2555 CZ PHE A 337 -34.931-25.002-21.993 1.0052.79 A

ATOM 2556 C PHE A 337 -33.409-31.207-2X345 LOO 53.76 A ATOM 2557 O PHE A 337 -33.431 -31.649-22.199 1^".0054.03 A

ATOM 2558 N- TYRA 338 -33.260-31.990-24.4041.0053.59 A

ATOM 2559 CA TYR A 338 -33.078-33.430-24.263 1.0053.90 A

ATOM 2560 CB TYR A 338 -31.713-33.704-23.690 1.0053.85 A

ATOM 2561 CG TYR A 338 -30,641-33.395-24.665 1.0054.48 A ATOM 2562 CDi TYR A 338 -30.453 -32.090 -25.132 1.0053-97 A ATOM 2563 CElTYR A 338 -29.432-31.798-26.0171.0054.76 A ATOM 2564 CD2 TYR A 338 -29.791-34.402-25.1101.0054.33 A ATOM 2565 CE2TYRA338- -28.769-34.133-25.983 1.0054.46 A

ATOM 2566 CZ TYR A 338 -28.582-32.838-26.438 1.0054.89 A ATOM 2567 OH TYRA 338 -27.520-32.631 -27.294 LOO 55.05 A

ATOM 2568 C TYRA 338 -34.1132 -34.167 -23.421 1.0053.93 A

ATOM 2569 O TYRA 338 -33.7S3 -35.128 -22.71-8 13054.37 A

ATOM 2570- N- ASN A 339 -35.336 -33.699 -23τ478 1.005X96 A

ATOM 2571- CA ASN A 339 -16.MΘ-34.322 -22.723 1.Θ054.10 A ATOM 2572 CB ASN A339 -36.820 -33,405 -21.571 L0£L53.08 A

ATOlVf 2573 CG ASNA 339 -37J656 -32.23-1 -22.0391:0052:55 A ATOM 2574 ODl ASN-A 339 -37.626 -3L864 -23.216 1.0052.15 A ATOM 2575 NB2 ASN A 339 -38.402 -31.630 -2U1-8 1.0051.16 A

ATOM 2576 C ASNA 339 -37.610 -34.591 -23.6541.0054.50 A ATOM 2577 O ASN A 339 -38.735-34.810-23.203 1.0054.64 A

ATOM 2578 N ALA A 340 -37.355-34.558-24.961 1.0054.05 A

ATOM 2579 CA ALA A 340 -38.382-34.822-25.973 1.0053.75 A

ATOM 2580 CB ALAA 340 -38.758-36.301-25.9471.0051.59 A

ATOM 2581 C ALA A 340 -39.643-33.986-25.778 1.0054.24 A ATOM 2582 O ALA A 340 -40.652-34.220-26.4471.0054.79 A

ATOM 2583 N- ALA A 341 -39.591-33.000-24.8931.0054.43 A

ATOM 2584 CA ALA A 341 -40.789-32.226-24.633 1.0055.41 A

ATOM 2585 CB ALA A 341 -41.382.-32.679-23.298 1.0055.58 A ATOM 2586 C ALA A 341 -40.568-30.711-24.633 1.0056J6 A

ATOM ^"2587 O ALA A 341 -41.479-29.936-24.9291.0057.20 A

ATOM 2588 N ASP A 342 -39.353-30.280-24.3021.0055.55 A

ATOM 2589 CA ASP A 342 -39.049-28.849-24.251 1.0055.06 A

ATOM 2590 CB ASP A 342 -38.468-28.481-22.8771.0057.77 A ATOM 2591 CG^" ASP A 342 -39.431-27.809-21.9591.0059.63 A

ATOM 2592^"OD-I ASP A 342 -40.589-28,354-21.793 1.0060.49 A

ATOM 2593^' OD2 ASP A 342 -39.157-26.739-21.394-1.0060.48 A

ATOM 2594 C ASP A 342 -38.064-28.471-25.3401.0052.91 A

ATOM 2595 O ASP A 342 -36.931 -28.952 -25.3501.0051.85- A ATOM 2596 N PHE A 343 -38.521-27.621-26.2591.0050.64 A

ATOM 2597 CA PHE A 343 -37.706 -27.135 -27.368- 1.0047.60 A

ATOM 2598 CB PHE A 343 -38.053-27.854-28.685 1.0045.62 A

ATOM 2599 CG PHE A 343 -38.140-29.355-28.5791,0042.99 A

ATOM 2600 CDl PHE A 343 -39.370-29.979-28.3541.0042.00 A ATOM 2601 CD2PHEA343 -37.000-30.144-28.725 LOO 41.74 A

ATOM 2602 CEl PHE A 343 -39.466 -31.369 -28.27S 1.0042.05 A

ATOM 2603 CE2PHEA.343 -37.080 -3L542 -28.6521:0041,91 A

ATOM 26.04. GZ PHE A 343 -38.318 -32.156 -28.4271.0041.69 A

ATOM 2605 C PHE-A343 -38.065-25.660 --27.494 JLO0-46.95__. A ATOM 2606. O PHE A 343 -39.238 -25.322 -27.703^" 1^:.0046.15 A

ATOM 2607- N AfcA A 344 -377077 -24.7-82 -277358' 1.0046:63 A

ATOM 2608 CA ALA A^"34^ -37.356 -23:355 -27,4501.00-46.82_ A

ATOM 2609- GB ALA A 344 -37.538-22.781-26.061 1.0046.81 A

ATOM 2610 C ALA A 344 -36.320-22.534-28.2221.0047.03 A ATOM 2611 O ALA A 344 -35.200-22.993-28.5061.0046.36 A

ATOM 2612 N DLE A 345 -36.715-21.313-28.5571.0046.64 A

ATOM 2613 CA ILE A 345 -35.873-20.403-29.2981.0047.95 A

ATOM 2614 CB ELE A 345 -36.461-20.097-30.6901.0048.62 A

ATOM 2615 CG2ILEA345 -35.842-18.824-31.2561.0049.50 A ,_™

458

ATOM 2616 CGl ILE A 345 -36.203-21.289-31.620 1.0048.24 A

ATOM 2617 CDl ILE A 345 -36.677-21.071-33.0361.0048.75 A

ATOM 2618 C ILE A 345 -35.699-19.123-28.5201.0048.75 A

ATOM 2619 O ILE A 345 -36.633-18.594-27.9161.0049.10 A ATOM 2620 -N LYS A 346 -34.482-18.611-28.571 1.0049.39 A

ATOM- 262L CA LYS A 346 -34.137 -17.417 -27.835 1.0049.28 A

ATOM 2622 CB LYS A 346 -33.074-17.786-26.8561.0048.73 A

ATOM 2623 CG LYS A 346 -32.918-16.811-25.8001.0048.66 A

ATOM 2624 CD LYS A 346 -31.559~16-.997 -25.301 1.0048.38 A ATOM.2625 CE JLYS A 346 -30.722-15.894-25.831 1.0047.65 A

ATOM 2626- NZ LYS^"A 346 -29.4-12^~16.447 -26.201 1.0048.75 A

ATOM -2627 C LYS A 346 -33.607 -Ϊ6-399 -28.802- 1.0049.14 A

ATOM 2628 O LYS A 346 -32.601-16.634-29.4581.0049.20 A

ATOM 2629 N- -GLN A 347 ,34.237 -15.243 -28.856 LOO 49.02 A ATOM 2630 CA- GLNA 3^~47 -33.788-14.312-29.8441.0050.39 A

ATOM 2631 CB GLNA347 -34.039 -15.0Q6 -31.171 1.0051.39 A

ATOM 2632 CG GLN A 347 -33.526-14.379-32.3901.0051.93 A

ATOM 2633 CD GLNA 347 -34.381 -14.773 -33.582 L.0052.28 A

ATOM 2634 OEl GLN A347 -34.517-15.960-33.9181.0052.46 A ATOM 2635 NE2 GLN A 347 -34.979-13.769-34.225 1.0052.47 A

ATOM 2163.6 C GLN A 347^" -34.488-13.002-29.538 LOLO 50.69 A

ATOM 26370 GEN A 347 -35.636-12.996-29.070 LOO 50.29 A

ATOM 263-8-N CYS_A348 -33.787 -Lϊ:900 -29.818 1.0051.09 A

ATOM 2639 CA^" CYS A 348 -34.293 -10.546 -29≡54.6~L0052.49^" A ATOM 2640-e CYSA348 -34:809-^0.006 -30:874 LOO 53.29 A

ATOM 264L-O CYS A 348 -34.196-9.097-31.492 1.0053.80 A

ATOM 2642-CB-CYS-A 348 -33^".232 -9.614 -28.97S 1.0053.27 A

ATOM 2643 SG CYSA X48 -32.624 -1&067 -27.3241.0051.81 A

ATOM 2644 N THRA 349 -35:93.6 -10.547-31.3241.0053.21 A ATOM 2645 CA THR A 349 -36.490-10.194-32.6271.0052.62 A

ATOM 2646 CB THR A 349 -37.836-10.908-32.8521.0052.36 A

ATOM 2647 OGl THR A 349 -37.680-12.313-32.620 1.0051.47 A

ATOM 2648 CG2THRA349 -38.238-10.838-34.318 1.0052.31 A

ATOM 2649 C THR A 349 -37.272 -8.940-33.0061.0052.87 A ATOM 2650 O THR A 349 -38.244 -8.579 -32.342 1.00 52.22 A

ATOM 2651 N ARG A 350 -36.842 -8.280 -34.076 1.00 53.88 A

ATOM 2652 CA ARG A 350 -37.221 -6.894 -34.327 1.00 55.07 A

ATOM 2653 CB ARG A 350 -38.392 -6.064 -33.796 1.00 55.45 A ATOM 2654 CG ARG A 350 -38.663 -4.795 =34.590 1.00 56.32 A

ATOM 2655 CD ARG A 350 -39:699 -3.877 -33.962- 1.00 58.94 A

ATOM 2656 NE ARG A 350 -39.632 -2.524 -34.506 1.00 61.93 A

ATOM 2657 CZ ARG A 350 -40.644 -1.667 -34.503 1.00 63.89 A ATOM 2658 NHl ARG A 350 -41.812 -2:020 -33τ983 l.ϋO 63.5S A ATOM 2659 NH2 ARG A 330 -40.493 -0.456 -35.0Ϊ9 1.00 64.58 A

ATOM 2660 C ARG A 350" -37.170 =6.876-35:852 1.00 55.6Θ A

ATOM 2661 O ARGA350 -36.339 -6.188 -36.446 1.00 58.50 A

ATOM 2662 N VAL A 351 -38.063 -7:635 -36.480 1.00 53.68 A

ATOM 2663 CA VAL A 351 -38.%5 -7.086 -37.487 1.00 52.44 A ATOM 2664 CB VAL A 351 -39.807 -5.934 -36.907 1.00 5-1,86^" A

ATOM 2665 CGl VAL A 351 -40.691 -5.326 -37.985 1.00 51.14 A

ATOM 26.66 CG2 VAL A 351 -40.644 -6.423 -35.735 1,00 52.78 A

ATOM 2667 C VAL A 351 -38.243 -6.595 -38.738 1.00 51.90 A

ATOM 266S O VALA 351 -38.610 -5.572 -39.317 1.00-50.46 A ATOM 2669 N THRA 352 -37.216 -7.331 -39.151 1.00 51.27 A

ATOM 2670 CA THRA 352 -36.53XL -7.Θ56 -40.409 l.Oθ 50.18 A

ATOM 2671 CB THRA 352 -35.087 -6.591 -4ΘJ-42 1.00 50:52 A

ATOM 2672 QGl THR Aθ52 -35.103 -5.286 -35-551 1.0Θ-50.64 A-

KLΘM 267-3_; CGEfTHR A 352 -34.345 -6375 -41.451 1.00^51.46 A ^" ATOM 2674 C THR A 352 -36.524^~ -8:292 -41.303- 1.00 49.35" A

ATOM 2675 O- THR A 352 =36:655 -5T.416 -40.821 1.00 49.71 A

ATΘM 2676, N ALA A 353 -36.372 -8:079 -42J607 1.0049.95 A

ATOM 2677 CA ALA A 353 -36.272 -9.188 -43.545^" 1.0049.33 A-

ATOM 2678 CB ALA A 353 -36.112 -8.672 -44.971 1.00 5Θ.10 A ATOM 2679 C ALA A 353 -35.097 -10.085 -43.168 1.0048.85 A

ATOM 2680 O ALA A 353 -35.259 -11.294 -43.004 1.0048.70 A

ATOM 2681 N ASP A 354 -34.041 -9.434 -42.867 1.0049.55 A

ATOM 2682 CA ASP A 354 -32.853 -10.052 -42.539 1.00 51.24 A

ATOM 2683 CB ASP A 354 -32.028 -8.876 -42.242 1.00 51.45 A ATOM 2684 CG ASP A 354 -32.373 -7.779-43.1541.0055.11 A ATOM 2685 ODl ASP A 354 -31.611 -7.524-44.096 1.0054.81 A ATOM 2686 OD2 ASP A 354 -33.430 -7.180-43.098 1.0052.60 A

ATOM 2687 C ASP A 354 -33.044-10.945-41.4061.0050.22 A

5 ATOM 2688 O ASP A 354 -32.387 -11.930^' -41.259 LOO 46.16 A

ATOM 2689 N GLN A 355 -33.923 -10.526 -40.5271.0050,78 A ATOM 2690 CA GLN A 355 -34.264-11.339-39.392 1.0050.64 A ATOM 2691 CB GLNA 355 -34.444-10.543-38.147 1.0051.36 A ATOM 2692 CG GLN A 355 -33.722-11.244-36.999 1.0051.64 A

10 ATOM 2693 CD GLN A 355 -33.468-10.398-35.831 1.0049.18 A ATOM 2694 OEl GLN A 355 -32.433-10.532-35.1921.0046.95 A ATOM 2695 NE2 GLN A 355 -34.41,1 -9.519-35.5271:0044-92 A

ATOM 2696 C GLN A 355 -35.383-12.320-39.601 1.0050.72 A

ATOM 2697 O GLNA355 -35.445-13.319-38.9271.0047.38 A

15 ATOM 2698 N LEUA^"356 -36200-12.092-40.6191.0047.61 A ATOM 2699 CA LEU A 356 -37.235 -13.040 -40.8981.0046.73 A ATOM 2700 CB LEUA 356 -38.287 -12.443 -4L854 LOO 45.40 A ATOM 2701 CG LEU A 356 -39.470-13.429-42.014 1.0044.28 A ATOM 2702 CDl LEU A 356 -39.509-14.422-40.865 1.0043.66 A

20 ATOM 2703 CD2LEUA356 -40.784-12.720-41.9981.0043.08 A

ATOM 2704 C LEUA 356 -36.636-14.348-41.4371.0047.55" A

ATOM 2705 O- LEUA-356 -37.263 -1X408-41.3J88 1.0047.69 A

ATOM -27G6 N ALA-A 357 -3fτ413 -14,292 -41.94-7 LOO 44.89 A ATOM^" 2707 CA ALAA 351 -34.796-15.524-42.452 1:004483 A

^■25- ATOM _2708 CB-AbA-A 357 -33.843-15.231-43.6401.00-44.43 A

ATOM 2709 C ALA A 357 -34.046-16.201-41.313 1.0043.56 A-

ATΘM 2710-O ALAA337 -33.866-17.427-41.2881.0042.59 A

ATOM 2711 N THR A 358 -33.610 -15.385 -40359 LQO 43.36 A ATOM 2712 CA THR A 358 -32.910 -15.907 -39.189 LOO 41.64 A

30 ATOM 2713 CB THR A 358 -32.345-14.784-38.2941.0041.49 A ATOM 2714 OGl THR A 358 -31.178-14.223-38.903 1.0042.09 A ATOM 2715 CG2THRA358 -31.956-15.337-36.939 1.0043.50 A

ATOM 2716 C THRA 358 -33.927-16.710-38.391 1.0038.97 A

ATOM 27170 THRA 358 -33.596-17.707-37.758 1.0037.61 A ATOM 2718 N VAL A 359 -35.174-16.263-38.4321.0037.85 A

ATOM 2719 CA VAL A 359 -36.233-16.968-37.741 1.0036.72 A

ATOM 2720 CB VAL A 359 -37.565-16.201-37.831 1.0036.73 A

ATOM 2721 CGl VAL A 359 -38.706-17.079-37.325 LOO 35.48 A ATOM 2722 CG2 VAL A 359 -37.473 -14.909 -37.016 1.0036.05 A

ATOM 2723 C VAL A 359 -36.382 -18.341 -38.383 1.0037.49 A

ATOM 27240 VAL A 359 -36.498-19.348-37.673 1.0037.78 A

ATOM 2725 N HIS A 360 -36.372-18.384-39.7201.0036.64 A

ATOM 2726 CA HIS A 360 -36.481-19.656-40.428 1.0035.57 A ATOM 2727 CB HIS A 360 -36.529-19.452-41.9491.0034.70 A ATOM- 2728 CG HIS A 360 -37.831-18.908-42.4471.0033.84 A

ATOM 2729 CD2 HIS A 360 -38.855 -19.506 -43.0991.0033.50 A

ATOM 2730 NDl HIS A 360 -38.205 -17.593 -42.2671.0033.16 A

ATOM 2731 CEl HIS A 360 -39.404-17.402 -42 J89 1.0033.79 A ATOM 2732 NE2 HIS A 360 -39.822 -18.548 -43.300 1.0034.67 A

ATOM 2733 C HIS A 360 -35.272-20.510-40.066 LOO 35.21 A

ATOM 2734 O HIS A 360 -35.394-21.697-39.761 1.0034.44 A

ATOM 2735 N HIS A 361 -34.103-19.884-40.091 1.0035.76 A

ATOM 2736 CA HIS A 361 -32.856- -20.565 -39.7701.0036.76 A ATOM 2737 CB HIS A 361 -31.716-19.557-39.6571.0035.8-1 A

ATOM 2738 CG HIS A 361 -3O.458--20.134 -39.0841.0035.15 A

ATOM 2739-CD2IBSA361 -29.926 -2O;Θ48 -3778441.0033.67 A

ATOM 2740 NDl HIS A-36J -29.600 -20^934 -39.8121.0Θ 36.20 A-

ATOM 2741 CEl HIS A 361 -28:593-21.3-13-39.044 Ii)O 34.17 A ATOM 2742 NE2 HIS=A 361 -28JZ6.8 -20r789 -37ΛS451.-0032.95 A

ATOM ^"2743 C HIS A 361 -32.963 -21.306-38.457 t.09-37.04 A

ATOM 2744 θ HIS A 361 -32.581 -22.479-383581.00-36.98 A

ATOM 2745 N GLU A 362 -33.470-20.594-37.452 LOO 37.61 A

ATOM 2746 CA GLU A 362 -33.633-21.139-36.109 1.0038.09 A ATOM 2747 CB GLU A 362 -33,992-20.024-35.116-1.003-7.70 A

ATOM 2748 CG GLU A 362 -32.895-18.953-34.9071.0036.48 A

ATOM 2749 CD GLU A 362 -31.544-19.540-34.553 1.0036.69 A

ATOM 2750 OEl GLU A 362 -31.507-20.596-33.8861.0039.13 A

ATOM 2751 OE2GLUA362 -30.520-18.937-34.9301.0035.47 A _4Λ9

462

ATOM 2752 C GLU A 362 -34.683-22.243-36.0841.0039.02 A

ATOM 2753 O GLU A 362 -34.439-23.319-35.5141.0038.92 A

ATOM 2754 N MET A 363 -35.838-21.995-36.705 1.0039.33 A

ATOM 27.55 CA MET A 363 -36.885-23.020-36.761 1.0039.83 A ATOM 2756 CB MET A 363 -38.053-22.586-37.6301.0041.06 A

ATOM 2757 CG MET A 363 -39.005-21.623-36.9651.0043.15 A

ATOM 2758 SD MET A 363 -40.724-22.185-37.1271.0045.53 A

ATOM 2759 CE MET A 363 -41.545-20.938-36.122 1.0044.03 A

ATOM 2760 C MET A 363 -36.315-24.287-37.3541.0039.32 A ATOM 2761 O MET A 363 -36.777-25.379-37.066 1.0040.37 A

ATOM 2762 N GLY A 364 -35.313-24.131-38.202 1.0039.06 A

ATOM 2763 CA GLY A 364 -34.701-25.281-38.823 1.0039.71 A

ATOM 2764 C GLY A 364 -34.056-26.166-37.790 1.0040.19 A

ATOM 2765 O GLY A 364 -34.027-27.393-37.943 LOO 40.77 A ATOM 2766 N HISA 365 -33.533-25.548-36.733 1.0040.39 A

ATOM 2767 CA HIS A 3-65 -32.878-26.302-35.6571.0040.52 A

ATOM 2768 CB HIS A 365 -32.080 -25.360-34.7591.0038.69 A

ATOM 2769 CG HIS A 365 -30.808-24.872-35.373 1.0036.64 A

ATOM 2770 CD2 HIS A 365 -30.355-23.616-35.6121.0035.39 A ATOM 2771 NDl HIS-A 365 -29.807-25.727-35.785 1.0036.12 A

ATOM 2772 CEl HIS A 365 -28.791-25.019-36.2481.0035.70 A

ATOM 2773 NE2HESA365 -29.098 -=23.736 -36.1541.003539 A

ATOM 2774 C HIS A 365 -33:938 -27.023 -34,834 LSO 4133 A

ATOM" 2775 O ΗϊSrA36S -33.819-28.218-34.533 IJQO 39:61 A ATOM 2776 N ILRA 366 -34.982 -26-.Z74 -34_^4871.00-42.54- A

ATOM 2777 CA TLE A366 -36.099 -26.79S:-33.720 U90-44.33 A

ATOM 2778 CB- ILEA 366 -37.179 -25.711 -33.536 L00-44.00 A

ATOM 2779 CG2ELEA366 -38352 -26.260 -32.7621.0044.43 A-

ATOM 2780 CGl ELE A 366 -36.566-24.506-32.8301.0045.26 A ATOM 2781 CDl DLE A 366 -35.706-24.883-31.6341.0046.64 A

ATOM 2782 C ILE A 366 -36.715-28.004-34.4241.0045.53 A

ATOM 2783 O ELE A 366 -36.952-29.041-33.7971.0045.64 A

ATOM 2784 N GLN A 367 -36.961-27.859-35.728 1.0046.57 A

ATOM 2785 CA GLN A 367 -37.554-28.918-36.533 1.0047.02 A ATOM 2786 CB GLN A 367 -37.833-28.434-37.954 1.0047.64 A

ATOM 2787 CG GLN A 367 -38.560-29.479-38.792 1.0049.36 A

ATOM 2788 CD GLN A 367 -40.026-29.613-38.413 1.0049.00 A

ATOM 2789 OEl GLN A 367 -40.643-30.666-38.604 1.0049.43 A ATOM 2790 NE2 GLN A 367 -40.595 -28 J36 -37.886 1.0048.52 A

ATOM 2791 C GLN A 367 -36.656-30.140-36.599 1.0046.97 A

ATOM 27920 GLN A 367 -37.134-31.255-36.764 1.0046.51 A

ATOM 2793 N TYR A 368 -35.353-29.928-36.480 1.0047.60 A

ATOM 2794- CA TYRA 368 -34.421 -31.037 -36.532 1.00-49.41 A ATOM 2795 CB TYRA368 -33.002-30.507-36.746 1.0049.31 A

ATOM 2796- CG TYR A368 -32.075 -31.460 -37.473 LOO 50.12 A

ATOM 2797 CDl TYR A 368 -30.955 -30.986 -3«.149 LOO 50.34 A

ATOM 2798 CEl TYR A 368 -30.083-31.853-38.813 1.0051.08 A

ATOM 2799 CD2 TYR A 368 -32.305-32.835 -J7.476 1.0051.00 A - ATOM 2800 CE2 TYR A 36-8 -31.4J6 -33.715 -38.139 1.0051.70 A

ATOM 2801 CZ TYRA 368- -30.325 -33.217 -38.805 1.0051.66 A

ATOM 2802 OH TYRA 368 -29.450-34.083-39.441 1.0051.66 A

ATOM 2803 C TYR A 368 -34.547-3-1.772-35.2OT 1.0051.19 A

ATOM 2804 O TYR A 368 -34.488-33.010-35.137 1.0052.72 A ATOM 2805 N TYR A369 -34.740-30.997-34.136 1.0052.21 A ATOM 2806 -CA TYR A 369 -34.899-31358-32.793 1.0053.24 A ATOM^" 2807 CB TYR A363 -35τO44 -30.436 -31.758 1.0052.94- A ATOM 2808 CG TYR A- 369 -33.840-29.542-31.642 1.0052.22 A ATOM- 2809- CDl TYR A-369 -33.996-28. L76.-31.424 1.0051.70 A AXOM ^"2810 CEl TYR A 369 -32.900-27.337-31.34.1 1.0052.85 A ATOM- 28-11 CD2 TYRA 369 -32.546-30:057-31,768 1:005236 A ATOM 28Ω CE2TYRA369 -31.435 -29:229 -31.685 LOO^'52.94 A ATOM 2813 CZ TYR A 369 -31.618-27.866-31.475 1.0053J65 A ATOM 2814 OH TYR A 369 -30.526-27.024-31.418 1.0055.42 A ATOM 2815 C TYRA369 36.159-32.414-32.764 1.0053.41 A

ATOM 2816 O TYR A 369 36.113-33.621-32.475 1.0053.08 A

ATOM 2817 N LEU A 370 -37.28431.767-33.064 1.0052.00 A

ATOM 2818 CA LEU A 370 -38.57332.434-33.090 1.0049.93 A

ATOM 2819 CB LEUA 370 39.61731.526-33.733 1.0048.29 A ATOM 2820 CG LEU A 370 -39.807-30.138-33.1301.0047.36 A

ATOM 2821 CDl LEU A 370 -40.730-29.324-34.017 1.0045.59 A

ATOM 2822 CD2 LEU A 370 -40.383-30.254-31.7371.0046.95 A

ATOM 2823 C LEU A 370 -38.515 -33.-747-33.8721.0050.69 A ATOM 28240 LEU A 370 -39.155-34.727-33.5001.0054.36 A

ATOM 2-8-25 N GKN A 371 -37.73-7-33.774-34.9471.0050.60 A

ATOM 2826 CA GLN A 371 -37.661-34.966-35.7771.0049.99 A

ATOM 2827 CB GLN A 371 -37.157-34.615-37.1871.0048.83 A

ATOM 282? UG GLN A 371 -38.091^"-33.72G -38.019 1.0046.57 A ATOM 2829 CD GLN A 371 -39.483 -34.298 -3«. L7G 1.0044.88 A

ATOM^" 2830 OEl-GLN A 37-1 -39.653-35.516-38.2621.0043.43 A

ATOM 2831 NE2GLNA371 -40.487-33.424-38.2141.00-42.86- A

ATOM 2832 C GLN A 371 -36.821-36.112-35.236 1.0050.17 A

ATOM 2833 O GLNA 371 -37.164-37.272-35,4471.0049.15 A ATOM 2834 TJ TYR A 372 -35.745-35.823-34.491 1.0048.86 A

ATOM 2835 CA TYRA 372. -34.899-36.933-34.073 1.0049.15 A

ATOM 2836 CB TYR A 372 -33.436-36.655-34.4201.0050.57 A

ATOM 2837 CG TYR A 372 -32.936-35.311-33.9391.0051.69 A

ATOM 2838 CDl TYR A 372 -31.597-34.562-34.063 1.0053.10 A ATOM 2839 CEl TYRA 372 -31.136-33.735-33.624 1.0053.80 A

ATOM 2840^"CB2:TYRA-372 -33.803 -.34.393 -33.3621.0050.23 A

ATΘM 2841 CETT-YR A 372 -33.350 -33.164--32.919 1.0050:67 A

-ATOM 2842 CZ TYRA 372 -32.017 -32.840 -33.Θ541.0053.11 A

ATOM 2843 OH TYR-A 372 -31360.-31.619 -^"32.6-15 1:01158.49 A- A-T-ΘM 2844- C ΕYRA372 -35.041-37.201-32.578 1.0048.2T A

ATOM 2845 O TYR-A 372 -34,267-38:089-32:0591.0046.8.0^" A

ATOM .2846 N LY-S A 373 -35.928^ -^"36.560 -31.8941.0048.37 A

ATOM 2847 CA. LYS A=373 -36.037 -36-.791 -30.46.6 1.0048.41 A

ATOM 2848 CB LYS A 373 -37.262-36.091-29.9001.0045.55 A ATOM 2849 CG LYS A 373 -38.533-36.847-30.0461.0043.98 A

ATOM 2850 CD LYS A 373 -39.579-35.811-30.1601.0042.88 A

ATOM 2851 CE LYS A 373 -40.955-36.346-30.0801.0041.31 A

ATOM 2852 NZ LYS A 373 -41.825-35.153-29.9361.0038.40 A

ATOM 2853 C LYS A 373 -36.117-38.266-30.141 1.0050.79 A „,

465

ATOM 2854 O LYS A 373 -35.546-38.726-29.1471.0050.25 A

ATOM 2855 N ASP A 374 -36.802-39.013-31.0001.0049.63 A

ATOM 2856 CA ASP A 374 -36.974-40.429-30.763 1.0050.66 A

ATOM 2857 CB ASP A 374 -38.208-40.929-31.491 1.0052.47 A ATOM 2858 CG ASP-A 374- -39,475 -40.311 =30.931 1.0054.61 A

ATOM 2859 ODl ASP A 374 -39T701 -40.379 -29.6881.0055.39 A

ATOM 2860 OD2 ASP A 374 -40.240-39.723-31.7241.0056.56 A

ATOM 2861 C ASP A 374 -35.779-41.348-30.9961.0050.62 A

ATOM 28620 ASP A 374 -35:907-42.445 -31.505- 1.0050.82 A ATOM 2863 N ALA A 375 -34.602^" -40.899 -30.593 1.0050.96 A

ATOM 2864 CA ALAA 375 -33.445-4-1.774-307650 1.0051.69- A

ATOM 2865 CB ALAA 375 -32.535 -41.443 -3 T:866- 1.0051,00 A

ATOM 2866 C ALA A 375 -32.726-41.599-29.3101.0052.00 A

ATOM 2867 O ALA A 37-5 -33.301-41.049-28.3601.0051.50 A ATOM 2868 N PRO A 376- -31.483 -42.07-8 -29.2071.0052.78 A

ATOM 2869 CD PRO A 376 -3O.864-43.065-30.1101.0053.41 A

ATOM 2870 CA PRO A 376 -30.711-41.955-27.9671.0053.66 A

ATOM 2871 CB PRO A 376 -29.497-42.855-28.2171.0053.56 A

ATOM 2872 CG PRO A 376 -29.999 -43.863 -29.176 1.0052.68 A ATOM 2873 C PROA 376 -30.265-40.535-27.576 1.0054.21 A-

ATOM 28740 PRQA 376 -30-822 -39.521 -28.029 1.0054.09 A

ATOM 28.75 N ALA A 377 -29.254 -40v485 -26.712 1.0053,82 A

ATOM 2876-CA ALA A 377 =28.723 -39;220 -26^621:0053.27 A

ATOM 2877 CB ALA A 377^" -28.202 -39.338 -24.840 1.00323Ϊ A ATOM- 2878 C ALA A377 -27.598-38.823-27.183 1.0052.56 A

ATOM 2879 O^" ALA A377 -27.676 -37.809 -27.869 1:00-52.78 A

ATΘM 2880 N SERA 378 =26.562-39.651-27.2091.00-51.65- A

ATOM 28Sl CA SER A 378 -25.376^" -39.35.6 -27.9941.0051.97 A

ATOM 2882 CB SERA 378 -24.255-40.285-27.615 1.0052.47 A ATOM 2883 OG SER A 378 -24.784-41.333-26.8571.0053.41 A

ATOM 2884 C SERA 378 -25.480-39.287-29.502 1.0051.80 A

ATOM 2885 O SER A 378 -24.462-39.328-30.2141.0052.03 A

ATOM 2886 N LEU A 379 -26.706-39.154-29.9901.0051.58 A

ATOM 2887 CA LEU A 379 -26.922-38.933-31.401 1.0052.24 A ATOM 2888 CB LEUA 379 -26.878-40.211-32.222 1.0051.30 A

ATOM 2889 CG LEU A 379 -26.538-41.523-31.533 1.0050.80 A

ATOM 2890 CDl LEU A 379 -27.584-42.522-31.965 1.0050.10 A

ATOM 2891 CD2LEUA379 -25.125-41.978-31.8671.0050.39 A ATOM 2892 C LEU A 379 -28.2316 -38.184-31:6541:00-52.82 A

ATOM 2893 O LEU A 379 -28:993-38.54-1-32.5381.0053.41 A

ATOM 2894 N ALAA 380 -28.485-37.147-30.861 1.0053.65 A

ATOM 2895 CA ALA A 380 -29.484-36.142-31.203 1.0054.92 A

ATOM 2896 CB ALA A 380 -30.368-35.843-30:0021.0055.31 A ATOM 2897 C ALAA380 -28.827-34.865-31.715 1.0055.58 A

ATOM 2898 O ALA A 380 -29.150-33.766-312641.0055τ52 A

ATOM 2899^" N ARGA 381 -27-9-03 -35.017 -32.6581.0056.44 A

ATOM 2900 CA ARG A 381 -27.306-33.874-33.3371.0056.79 A

ATOM 2901 CB ARG A 381 -25.791-34.052-33.453 LQO 58.23 A ATOM 2902 CG ARG A 381 -25.011-33.536-32.2541.00-59.49 A

ATOM 2901 CD ARG A 381 -24.668-34.606-31.2301.0060.39 A

ATOM 2904 NE ARG A 381 -23.684-3-5.556-31.7391.00.61.96 A

ATOM 2905 CZ ARG A 381 -22.647-36.001-31.043 1.0062.52 A

ATOM 2906 NHl ARGA 381 -22.452-35.583-29.8001.0062.53 A ATOM 2907 NH2 ARGA 381 -21.802-36.866-31.5871.0062.94 A

ATOM 2908 C ARG A 381 -27.842-33.870-3^765 1.0055.97 A

ATOM 2909 O ARGA381 -28,911-34.416-35.038 L0θ^"-56τ93 A

ATOM- 2910 N GLY A 382- -27.092-33,252 -35.671 1.0054,10 A

ATOM 2911 CA GLYA 382 -27.318-33.565-37.070-1,0050.63 A ATOM 2912 C GLY A 382 -26.192 -34.3-85 -37.669- L0Θ-47.8Θ A

ATOM 2913 O GLYA 382 -25.135-347544-37.0601.0047.43 A

ATOM 29T4 N ALA-A 383 -26:422 -34.90-7 -38=869-1.0044.6.7 A

ATOM 2915 -CA ALA A 383 -25.469-35.825-39.5061.0041.50 A

ATOM 29 L6 CB ALA A 383 -25.749-35.888-40.9891.0044.79 A ATOM 2917 C ALA A 383 -24.057-35.282-39.245 1.0038.31 A

ATOM 2918 O ALA A 383 -23.097-36.016-38.9791.0035.32 A

ATOM 2919 N ASN A 384 -23.962-33.965-39.381 1.0035.47 A

ATOM 2920 CA ASN A 384 -22.759-33.195-39.060 1.0033.33 A

ATOM 2921 CB ASN A 384 -21.641-33.248-40.129 1.0033.51 A ATOM 2922 CG ASN A 384 -21.982-32.532-41.425 1.0034.03 A

ATOM 2923 ODl ASN A 384 -22.539-31.427-41.4421.0030.86 A

ATOM 2924 ND2 ASNA 384 -21.601-33.161-42.5341.0033.66 A

ATOM 2925 C ASNA 384 -23.260-31.778-38.791 1.0031.80 A ATOM 2926 O ASNA 384 -24.329-31.394-39.268 1.0031.00^" A

ATOM 2927^~N PRO A 385 -22.521-30.998-37.988 1.0030.57 A

ATOM 2928 CD PRO A 385 -21.133-31.251-37.572 1.0030.60 A

ATOM 2929 CA PRO A 385 -22.916-29.631-37.646 1.0030.84 A

ATOM 2930^" CB PRO A 385 -2T.640 -29.037 -37.0701.003O.58 A ATOM 2931 CG PRO A 385 -20.949-30.226-36.4971.0030.65 A

ATOM 2932 C PRO A 385 -23.435-28.849-38.82« 1.0031.89 A

ATOM 2933 O PRO A 385 -24.331 -28.007-38.688 1.003 L-41 A

ATOM 2934 N GLY A 386 -22.854-29.139-39.9921.0033.12 A

ATOM 2935 CA GLY A 386 -23.245-28.479-41.224 1.0031.34 A ATOM 2936 C GLY A 386 -24.706-28.688-41.561 1.003L70 A

ATOM.2937 O GLY A 386 -25.437-27.719-41.7971.0030.29 A

ATOM 2938 N PHE A 387 -25.138-29.948-41.586 1.0032.33 A

ATOM 2939 CA PHE A 387 -26,530-30.250-41.896 1.0034.08 A

ATOM 2940 CB PHE A 387 -26.830-31.736-41.695 1.0036.90 A ATOM 2941 CG PHE A 387 -26.237-32.636-42.754 1.0039.53 A

ATOM 29^~42 CDl PHE A 387 -24.864-32.651-42.993 1.0040.62 A

ATOM 2943 CD2LPHE A-387 -273052 -33.504 -43.48* 1.0040.02 A

ATOM 2944 CEl PHE A 35-7 -24.311 -33,527 -43.94_4_ 1.0042.29- A

ATOM^~ 2945- CETPHE A 337 -26.510=34.381-44=433 0041.71 A ATOM 2946 CZ PHE A 387- -25.138 -34.395 -44.6641.004L89 A

ATOM 2947 C PHE A 387 -27.46t-2ft431 -41.0171.0034.04 A

ATOM 2948 O PHE A 387 -^'28.47T -28τ899 -41.493 DOO 32.93 A^"

ATOM 2949 N HIS A 388 -27.107-29.315-39.738 1.003425 A.

ATOM 2950- CA HIS A 3S8 -27.939=28.565-38.798 1.0034.69 A ATOM 2951 CB HIS A 388 -27.361-28.625-37.368 1.0036.41 A

ATOM 2952 CG HIS A 388 -28.354-29.057-36.325 1.0035.88 A

ATOM 2953 CD2HISA388 -28371-30.137-35.5071.0035.37 A

ATOM 2954 NDl HIS A 388 -29.522 -28.364 -36.0671.0035.69 A

ATOM 2955 CEl HIS A 388 -30.216-29.003-35.141 1.0035.11 A ATOM 2956 NE2 HIS A 388 -29.541-30.081-34.784 1.0035.58 A

ATOM 2957 C HISA388 -28.117-27.111-39.213 1.0034.16 A

ATOM 29580 HIS A 388 -29.249-26.615-39.281 1.0033.08 A

ATOM 2959 N GLU A 389 -27.008-26.427-39.4991.0033.75 A ATOM 2960 CA GLU A 389 -27.0S6 -25.017 -39.8921.0033.57 A

ATOM 2961 CB GLU A 389 -25.683-24.393-39.938 1.0032.96 A

ATOM 2962 CG GLU A 389 -24.890-24.466-38.631 1.0031.84 A

ATOM 2963 CD GLU A 389 -25.654-23.929-37.405 1.0032.65 A

ATOM 2964 OEl GLU A 389 -26.427 -22.957 -37.532 LQO 31.41 A ATOM 2965 OE2GLUA389 -25.468-24.472-36.2961.0031.27 A

ATOM 2966 C GLU A 389 -27 -780 -24.8-38 -41.253 UDO 32.92 A

ATOM 2967 X) GLUA 389 -2*233 -23.740 -41.591 1.0033.27 A

ATOM 2968 N ALA A 390 -27.879-25.923-42.0141.0031.19 A

ATOM 2969 CA ALA A 390 -28.495-25.862-43.322 1.0029.86 A ATOM 2970 CB ALA A 390 -28.036-27.023-44.1391.0029.30 A

ATOM 2971 C ALA A 390 -30.012-25.871-43.2881.0030.07 A

ATOM 2972 O ALA A 390 -3O.674 -25.027 -43.902 LOO 28.73 A

ATOM 2973 N ILE A 391 -30.545-26,851-42.5641.0030.53 A

ATOM 2974 CA ILEA 391 -3L980 -27.075 -42,512^" 1.0032.75 A ATOM 2975 CB ILEAJ91 -32.3-86-27.887-41.2861.0032.25 A

ATOM 2976 CG2 ILE A 391 -33.S72 -28.232 -41.373 1.0030.36 A

ATΘM 2977 CGl BbE A" 391 -31.576 -29.187 -4-1.248 1.0032779 A

ATOM 2978 CDl-DLE A 391 -3-1.488-29.931.-42:5791.0033.41 A

AlBM- 2979 C ELE A 391 -32:918' -25.S87^~-42.6681.003-5,02 A_ ATOM 2980 O ILE A 391 -33?8S0 -25τ933 -43.504 1-00-3.7:22 A

-A-TOM 2981 N GLYA392 -32.711 -24^18 -4L913 1.0036.4Gr A

ATOM- 29S2-CA GLY A 392 -33.608 -23.687 -42.030- 1.W 37.72^" A

ATOM 2983 C GLY A 392 -33.263-22.813-43.199 1.0038.81 A

ATOM 2984 O GLYA 392 -34,144-22.150-43.736 1.0038.73 A ATOM 2985 N ASP A 393 -31.989-22.794-43.583 1.-0040.28 A

ATOM 2986 CA ASP A 393 -31.560-21.961-44.7001.0042.67 A

ATOM 2987 CB ASP A 393 -30.023-21.918-44.783 1.0044,44 A

ATOM 2988 CG ASP A 393 -29.412-20.843-43.881 1.0044.69 A

ATOM 2989 ODl ASP A 393 -29.756-20.790-42.682 1.0044.28 A ATOM 2990 OD2 ASP A 393 -28.577 -20.05Ϊ -44.3741.0046.33 A

ATOM 2991 C ASP A 393 -32.169-22.466-46.0101.0042.32 A

ATOM 2992 O ASP A 393 -32.625-21.672-46.843 1.0041.62 A

ATOM 2993 N VALJ⁵L 394 -32.197-23.785-46.1741.0041.70 A ATOM 2994 CA VAL A 394 -32.770-24.387-47.3.671.0041.3! A ATOM 2995 CB VAL A 394 -32.951-25.899-47.201 1.0040.79^' A ATOM 2996 CGl VAL A 394 -33.660-26.457-48.4001.0040.47 A ATOM 2997 CG2 VAL A 394 -31.595-26.581-47.0191.0040.21 A

ATOM 2998 C VAL A 394 -34.136-23.766-47.5951.0041.48 A ATOM 2999 O VAL A 394 -34.341 -23.038 -48J5681.0043.64 A

ATOM 3000 N LEU A 395 -35.064 -24.046- -46.6851.0040.22 A ATOM 3001 CA LEU A 395 -36.415 -23..505 -46.7861.0038.99 A ATOM 3002 CB LEU A 395 -37.252-23.854-45.5551.0039.04 A ATOM 3003 CG LEU A 395 -J7.716 -25.303 -45.358 1.0039.16- A ATOM 3004- CDl LEU A 395 -36.540 -26.221 -45.012 lJOO 37:82 A ATOM 3005 CD2 LEU A 395 -38.748-25.328-44.251 1.0038.09 A

ATOM 3006 C LEUA 395 -36.410-22.008-46.945 1.0033.83 A

ATOM 3007 O LEU A 395 -37.356-21.445-47.4841.0039.84 A

ATOM 3008 N ALA A 396 -35.357-21.358-46.4641.003S,76 A ATOM 3009 CA ALA A-396 -35.264-19.912-46.581 1.0039784 A ATOM 3010 CB ALA A 396 -34.079-19:406-45.801 1.0039.96 A

ATOM 3:0.11 -C ALA A 396 -35.122-19.522 -4S703Θ 1.0041.01 , A

ATOM 3012 O ALAA 396 -35.701-18.517-48.503 1JQ0.40-.26- A

ATOM 30-13- π LEUA 397 =-34:352-20.325 -48.791- L 0041:23 A ATOM 3014 CA LEU A 39-7 -34.122 -20.079 -50.214 JUKM0r75 A ATOM- 3015 CB^" LEU A 397- -33333 -21,230 -50.8391.0040.92 A- ATOM 3016 CG LEU A 397 -31.831-21:249 -50.5361.0041.38 A ATOM 3.017 CDl LEU A 397 -31.203 -22.506.-51.1201,0041.93 A ATOM- 3018 CD2LEUA397 -3 L 171 -20.000 -51.1141.00-44.50 A ATOM .3019 C LEUA.397 -35.446-19.908-50.9361.0040.52 A

ATOM 3020 O LEU A 397 -35.644-18.939-51.673 1.0040.11 A

ATOM 3021 N SERA 398 -36.356-20.847-50.702 1.0039.93 A ATOM 3022 CA SERA 398 -37.667-20.796-51.3261.0039.62 A

ATOM 3023 CB SERA 398 -38.433-22.082-51.028 1.0038.20 A ATOM 3024 OG SERA 398 -37.676-23.214-51.4171.0037.23 A

ATOM 3Θ25 C SERA 398 -38.473-19.587-50.8551.0039.92 A

ATOM 3026 O SER A 398 -39.254 -L9.022 -51.6101.0040.56 A

ATOM 3027 N VAL A 399 -38.282-19.177-49.6101.0040.01 A ATOM 3028 CA VAL A 399 -39.037-187050-49.099 LOO 40.24 A

ATOM.3029 CB VAL A 399 -38.923-17.939-47.554 1.0040.16 A

ATOM 3030 CGl VAL A 399 -39.901-16.908-47.0291.0038.55 A

ATOM 3031 CG2VALA399 -39.196-19.278-46.9121.0039.41 A

ATOM 3032 C VAL A 399 -38.566-16.759-49.733 1.0041.27 A ATOM 3033 O VAL A 399 -39.169-15.918-50.0801.0040.66 A

ATOM 3034 N SER A 400 -37.260 -16.609 -49.902 l.θθ 43.50 A

ATOM 3:035 CA SER A 400 -36.707-15.385-543.4781.0046.32 A

ATOM 3036 CB SER A 400 -35.181-15.440-50.4201.0046.65 A

ATOM 3037 OG SER A 400 -34.739-15.692-49.098 1.0046.46 A ATOM 3038 C SER A 400 -37.172-15.048-51.901 1.0047.73 A

ATOM 3039 O SER A 400 -37J89 -13.888 -52.3071.0047.20 A

ATOM 3040 N THR A 401 -37.562-16.074-52.6671.0048.69 A

ATOM 3041 CA THR A 401 -38.033-15.857-54.0361.0049.55 A

ATOM 3042 CB THRA 401 -38.465-17.193-54.665 1.0049.73 A ATOM 3043 OGl THR A 401 -39.662 -17.685 -54.0J671.0050.76 A

ATOM 3044 GG2 THR-A- 401 -37.350 -18.226-54.480^" LOO 49.22 A

ATOM 3045 C THRA 401 -39.110 -14.815 -53.8921.005.0.60 A

ATOM 3046-θ THR A 401 -39394-14.903 -53.030 1.0050.19 A

ATOM- 3047 N-SRO-A-402 -39.027 -13,732-54.6841.00:52.01 A AϊOM 3048 CD PRO A 402 -38.210-13.831-55:892 1.00-51.18. A

ATOM 3049 CA PRO A 402^' =39.906 -12.544r-54.795 l.QO 53_^56 A-

ATOM 3050 CB PRO A 402 -39.441--11.889 -56:058 1.00.52.46 A

ATOM 3051 CG PRO A 402 -37.927-12.411-56.1561.0051.93 A

ATOM 3052 C PRO A 402 -41.360-12.952-55.0521.0054.79 A ATOM 3053 O PRO A 402 -423.17-12.466-54.503 1.0055.92 A

ATOM 3054 N ALA A 403 -41323-13.918-55.9121.0056.57 A

ATOM 3055 CA ALA A 403 -42.426-14.609-56.4391.0057.68 A

ATOM 3056 CB ALA A 403 -41.928-15.573-57.505 1.0056.96 A

ATOM 3057 C ALA A 403 -42.821-15.353-55.0921.0058.24 A _m

ATOM 3058 O ALA A 403 -43.979-15.359-54.658 1.0058.22 A

ATOM 3059 N HIS A 404 -41.991-16.075-54.351 1.0058.80 A ATOM 3060 CA fflS A 404 -42.598-16.763-53,085 1.0059.78 A ATOM 3O61 CB HIS A 404 -41.617-17.559 -52.1Z71.0060.51 A ATOM 3662- CG fflS A 404 -42.306-18.205-50.935 1.0061.16 A ATOM 3063 CD2ΕSSA404 -42.338-17.856-49.623 1.0061.75 A ATOM 3064 NDl HIS A 404 -43.031-19.378-51.0261.0061.38 A ATOM 3065 CEl HIS A 404 -43.468-19.725-49.826 1.0061.10 A ATOM .3066- NE2-BQSA-404 -43:061-18.818-48.9571.0061.04 A ATOM 3067 C HIS A 404 -43.283-15.722-52.178 1.0060.08 A

ATOKT 3068 O HS A 404- -447409-15.899-51:6901.0060.60 A

ATOM 3069 N LEU A 405 -42:61:0-14.596-52.0021.0059.79 A ATOM 3070 CA LEU A 405 -43.138-13.503-51.1991.0059.46 A ATOM 30-71- CB LEU A 405 -42.133-12.369-51.1561.0059.73 A ATOM 3072 CG LEU A 405 -40.753-12.983-51.0191.0060.23 A ATOM 3073 CDl LEU A 405 -39.777-11.864 -50.9Q1 1.0060.43 A ATOM 3074 CD2 LEU A 405 -40.678-13,912-49.8091.0058.88 A

ATOM 3075 C LEU A 405 -44.462-12.937-51.649 1.0059.37 A ATOM 3076 O LEUA405 -45.271-12.558-50.8141.0059.91 A ATOM 3077 N HIS A 406 -44.684-12.851-52.9.541.0059.44 A AT-ΘM- 3078 CAJSSA4e6 -45.939 -12.287 -53.44J 1.0059.23 A ATOM^' 3079^" CB HIS A406 -45:961 -12.215-54.96S 1.0059.68 A ATOM 3Θ8Θ CG__HISA-486 -47.^3-9-11.663 -55.5171.00 j59:9θ A A-ΕΘM 3081^{^}-CD2 HIS A 406 -47.479 -10.561: -56265 1.0060,96 A ATOM -3082 M)I HIS A 406 -48L467-12.254-55J03 1.0060.36 A ATOM ^"3083 CEl HIS A 406 -49:407-1 Ϊ753-9 -55.8981.00.60.76 A ATOM 3034 NE2JHS A 406 -48.833-10:506-56:4891.0060.53 A

ATOM 3085 C HIS A 406 -47.071-13.181-52.9901.0058.59 A

ATOM 3086 O HIS A 406 -48.164-12.724-52.6471.0058.06 A ATOM 3087 N ALA A 407 -46.792-14.476-53.025 1.0057.83 A ATOM 3088 CA ALA A 407 -47.764-15.470-52.6291.0057.68 A ATOM 3089 CB ALA A 407 -47.168-16.848-52.745 1.0056.99 A ATOM 3090 C ALA A 407 -48.185-15.249-51.2041.0057.88 A ATOM 3091 O ALA A 407 -49.245-15.685-50.7591.0058.95 A _m

ATOM 3092 N ILE A 408 -47.354-14.555-50.462 1.0057.21 A

ATOM 3093 CA ILE A 408 -47.674-14.413-49.0661.0055.73 A

ATOM 3094 CB ILE A 408 -46.714-15.219-48.305 1.0054.45 A

ATOM 3095 CG2DLEA408 -45.8O6 -15.916-49.3061.00T4.71 A ATOM 3096 CGl IEE A 408 -45Λ86 -14345-47.3781.0053.43- A

ATOM 3097 CDl ILE A 408 -44.493 -14.765 -47.3871.00^"53_54 A

ATOM 3098 C ILE A 408 -47.738-13.005-48.5701.0055.55 A

ATOM 3099 O ILE A 408 -47.815-12.714-47.3761.0055.09 A

ATOM 3100 N GLY A 409 -47.716 -12.1O4-49.512^"1.0055.73 A ATOM 3101 CA GLY A 409 -47.936-10.775-49.059 1.0056.50 A

-ATOM 3102 C GLY A 409 -47:028 -9.634-49.105 1,0.0-57776 A

ATOM 3103 O GLY A 409 -47.506 -8.508-48.973 1.0057.11 A

ATOM 3104 N ALAA410 -45.765 -9.838-49.353 1.0060.07 A

ATOM 3105 CA ALA A 410 -44.991 -8.659--49.2671,0062.81 A ATOM 3106 CB ALA A 410 -44.039 -8,836-4871941.0063.37 A

ATOM 3107 C ALA A 410 -44.321 -8.147-50.513- 1.0064.64 A

ATOM 3108 O ALA A 410 -43.553 -7.195-50.438 1.0064.97 A

ATOM 3109 N LEUA 411 -44.657 -8.736-51.655 1.0066.13 A

ATOM 3110 CA LEU A 411 -44.102 -8.334 -5T.9141.0066.82 A ATOM 3111 CB LEUA411 -43.318 -9.490-53.4851.0066.56 A

ATOM 3112- CG LEU A411 -41.843- -9.L46L-53.3T53 LOO 66.6Φ A

ATOM 3313 CDlXEU A 411 -41.045^" -9:862 r-54.399 - 1.00-66.34 A

ATOM 3114 CD2 L-EU A 41 L -4b69-l- -7.648 -53.602 1.0066.84- -A

ATOM- 3 HTX LEU A 411 -45.307 -8:042 -53.759 h0067.82 A ATOM 31-160 LEU A 411 -45:862 -8,963-54.328 1.0θi63.26 A

ATOM 31-17 N ALA-A 412 -45.703 -6.776-53.843 1.0&6&4&. A

ATOM 3118^: CA ALAA412 -47:053 -6422_-54.2661.O0-68.97 A

ATOM 3119 -CB ALA A 412 -47.296 -4334-54.0691.0068.-66- A

ATOM 3120 C ALAA412 -47.302 -6.817-55.718 1.ΘQ-68.78 A ATOM 3121 O ALAA 412 -48.446 -6.864-56.170 1.0068.61 A

ATOM 3122 N ALA A 413 -46.225 -7.101-56.443 1.0069.31 A

ATOM 3123 CA ALA A 413 -46.194 -6.888-57.885 1.0069.72 A

ATOM 3124 CB ALAA413 -45.175 -5.816-58.2401.0069.12 A

ATOM 3125 C ALAA413 -45.887 -8.184-58.6271.0069.65 A ,„,

473

ATOM 3126 O ALA A 413 -46.002 -9.274-58.0661.0069.57 A

ATOM 3127 N ALA A 414 -45.497 -8.058-59.891 1.0069.78 A

ATOM 3128 CA ALA A 414 -44.089 -8.119-60.2681.0069.28 A

ATOM 3129 CB ALA A 414 -43..642 -9.566-60.413 1.0069.10 A ATOM 3130 C ALA A 414- -43:830 -7.348 -61.558 1.00-68.69 A

ATOM 3131 O ALA A 414 -44.721 -6.683-62.0851.0068.9-7 A

ATOM 3132 N ALA A 415 -42.603 -7.442-62.0601.0067.53 A

ATOM 3133 CA ALAA415 -42.354 -8.039-63.3671.0065.77 A

ATOM 3134 CB ALA A 415 -41.805 -6.997-64.330-1.0065:81 A ATOM 3135 C ALA A 415 -41.399 -9.223-63.259 1.0064.53 A

ATOM 3136 O ALA A 415- -40.595 -9.302-62.331 1.006*45 A

ATOM 3L37 N ALA A 416 -41.493 -10.142 -6_4.215 L0ϋ-63i)5 A

ATOM 3138 CA ALA A 416 -40.697-11.362-64.1851.0062.35 A

ATOM 3139 CB ALA A 416 -41.601-12.586-64.1951.0061.49 A ATOM 3140 C ALA A 416 -35.719-11.411-65.355 1.00-61.95 A

ATOM 3141 O ALAA-416 -39 '.868 -12.225 -66.2671.0062.79 A

ATOM 3142 N ASP A 417 -38.720-10.536-65.3221.0060.60 A

ATOM 3143 CA ASP A 417 -37.817-10.359-66.4571.0058.96 A

ATOM 3144 CB ASP A 417 -37.869 -8.898-66.890 1.0058.78 A ATOM 3145 CG ASP A417 -37.484 -7.941-65.7641.0059.40 A

ATOM 3146 ODl ASP A 417 -38.370 -7.473 -65.011 1.68 dQ.10 A

ATOM 3147 OD2 ASP A 41-7 -36.276 -7:651-65,623 1.0059.34- A

AXQM 3148rC ASP A 4X7 -36.409 -L0.720.-66τ0621.005S.21 A

AT-OM- 3149 O- ASP A317 -36Λ-87 -11.441 -65.090- LOft- 58.36 A AXOM 3150-N THRA418 -35.462 -10.2GΘ -66.828 1.0056.71 A

ATOM 3151 CA TBR-A-418 -34.057-10.423^66.561 l.-G054;sα A

ATOM 3152 CB- THKA 41-8 -33,217 -10r242 -67.8401.0052:85 A

ATOM 3153 OGl THR A418 -33.639 -9.062 -68.525 1.0052.50 A

ATOM 3-154 CG2 TfDLA 418 -33.369-11.426,68.7431.0052.69 A ATOM 3155 C THRA 418 -33.619 -9.406-65.498 1.0054.99 A

ATOM 3156 O THRA 418 -33.233 -9.784-64.398 1.0054.53 A

ATOM 3157 N GLUA 419 -33.714 -8.118-65.8221.0054.79 A

ATOM 3158 CA GLU A 419 -33.322 -7.066-64.889 1.0054.42 A

ATOM 3159 CB GLUA419 -33.888 -5.714-65.3361.0054.34 A _m

ATOM 3160 CG GLU A 419 -33.060 -5.054-66.424 1.0055.56 A

ATOM 3161 CD GLU A 419 -33.487 -3.624-66.710 1.0057.09 A ATOM 3162 OEl GLU A 419 -34.170 -3.020-65.853 1.0057.66 A

ATOM 3163 OE2GLUA419 -33.126 -3.096-67.7861.0058.09 A ATOM 3164 C GLU A 419 -33.738 -7.363-63.4501.0054.41 A

ATOM 3165 O GLUA 419 -32.913 -7.315-62.535 1.0054.72 A

ATOM 3166 N SER A 420 -35.009 -7.677-63.238 1.0053.65 A

ATOM 3167 CA SER A 420 -35.455 -7.986-61.8901.0051.88 A

ATOM 3168 CB SERA420 -36.972 -8.176-61.8541.0051.57 A ATOM 3169 OG SER A 420 -37.629 -6.948-62.121 1.0052.95 A

ATOM 3170 C SER A 420 -34.747 -9_258 -61.441 h0050.76 A

ATOM 3171 O SERA420 -34.332 -9.376 -60.291 1.0051.30 A

ATOM 3172 N ASP A 421 -34.593-10.199-62.365 1.0049.44 A

ATOM 3173 CA ASP A 421 -33.934-11.466.-62.0691.0048.34 A ATOM 3174 CB ASP A 421 -33.943-12.353-63.322 1.0049.20 A

ATOM 3175 CG ASP A 42-1 -33.579-13.800-63.025 1.0050.41 A

ATOM 3176 ODl ASP A 421 -34.043-14.329-61.995 1.0051.04 A

ATOM 3177 OD2 ASP A 421 -32.845-14.422-63.825 1.0050.80 A

ATOM 3178 C ASP A 421 -3Z505 -11.227 -61.5691.0047.30 A ATOM 3179 O ASP A 421 -32.074-11.833-60.5871.0046.69 A

ATOM 3180 N IEE A 422 -31-777 -10.337 -62.2421.0046.94 A

ATOM 3-1-81 CA ILE A 422 -30.406 -9.998-61.853 1.0045.84 A

ATOM 3182 CB ILE A 422 r29:754 -_8.990 -62.861 L8Θ 46.02 A

ATOM 3-183 CG2-DLEA422 -2-8.51? -8.337-62.253 1.0045:56 A ATOM 3L8.4_C&MLEA4-22 ^29.355 -9.715-64.1471.0045.43 A

ATOM 3185 CDl ELE A422 -28.177 -10.647 -63.9S-71.0044:02 A

ATOM 31-86 C ILE A 422 -30.428- -9^".3^"85 -60.448 1.0045.39 A

ATOM 3187 O ILE A 422 -29.689 -9.837 -59.571 LOO 45.74 A

ATOM 3188 N ASNA-423 -31.275 -8.37L -60,2341.0043.87 A ATOM 3189 CA ASN A 423 -31.397 -7.728 -58,923 LOO 42.18 A

ATOM 3190 CB ASN A 423 -32.622 -6.813-58.873 1.0041.12 A

ATOM 3191 CG ASN A 423 -32.400 -5.500-59.583 1.0040.90 A

ATOM 3192 ODl ASN A 423 -31.496 -4.746-59.2471.0040.28 A

ATOM 3193 ND2ASNA423 -33.232 -5.217-60.5701.0042.40 A ATOM 3194 C ASN A 423 -31.529 -8.785-57.8261.0042.16 A

ATOM 3195 O ASN A 423 -30.744 -8.816-56.8761.0042.09 A

ATOM 3196 N TYRA424 -32.526 -9.653-57.9661.0041.71 A

ATOM 3197 CA TYRA 424 -32.746-10.701-56.9891.0041.29 A ATOM 3198 CB- TYRA 424 -33,828-11.683-57.454-1.0041.15 A

ATOM 3199 CG TYRA 424 -33.954-12.923-56.579 1.0039.99 A

ATOM 3200 CDl TYR A 424 -34.270-12.826-55.221 1.0039.58 A

ATOM 3201 CEl TYRA 424 -34.333-13.967-54.401 1.0039.13 A

ATOM 3202 CD2 TYR A 424 -33.711-14.187-57.1021.0039.81 A ATOM 3203 CE2TYRA424 -33.770 -15.329 -56^".2971.004030 A

ATOM 3204 CZ TYR A 424 -34.Θ8Θ -15.216 -54.945 1.0039.63 A

ATOM 3205 OH TYR A 424 -34.119-16.347-54.151 1.0037.35 A

ATOM 3206 C TYR A 424 -31.466-11.454-56.7441.0041.74 A

ATOM 3207 O TYR A 424 -30.995-11.520-55.612.1.0043.62 A ATOM 3208 N LEU A 425 -30.902-12,022-57.8021.0041.76 A

ATOM 3209 CA LEU A 425 -29.676-12.791-57.6661.0041.35 A

ATOM 3210 CB LEU A 425 -29.224-13.321-59.0321.0042.74 A

ATOM 3211 CG LEU A 425 -29.839 -14.646 -59.4&S 1.0042.03 A

ATOM 3212 CDl LEU A 425 -29.111-15.141-60.7271.0042.66 A ATOM 3213 CD2LEUA425 -29.702-15.680-58.3821.0043.07 A

ATOM 3214 C LEU A 425 -28.540 -12.015^"-57:0O5 1.0040,45 A

ATOM 3215 O LEU A 425 -27:734-12.604-56,277 LOO 3-9.47 A

ATOM 3216 N- LEU A 426 -28.464 -10J707 -57.254 LOO_39:Θ9 A

ATOM.3217- -GA LEU A 426 -27.402 -9.921 -56.644- 1.0038.12 A- ATOM 321-8 CB LBU A 426 -27.302. -8.548-57.2471.9£t35.86 A

ATOM 3219 CG LEU A426- -26.257 -77712 -56.4621. OO 35.07 A

ATOM- 3220 CDJ LEUΑ-426 -24.859 -8.087 -56.899 1.0033.95 A

ATOM 3221 CD2LEUA426 -26.478-6.246-56.658 1.0035.09 A

ATOM 3222 C LEU A 426 -27.689 -9.813-55.1541.0038.69 A ATOM 3223 O LEU A 426 -26.793 -9.989-54.3261.0038.47 A

ATOM 3224 N LYS A 427 -28.942 -9.535 -54.8061.0039.41 A

ATOM 3225 CA LYS A 427 -29.297 -9.429-53.3961.0038.93 A

ATOM 3226 CB LYS A 427 -30.798 -9.227-53.2071.0040.26 A

ATOM 3227 CG LYS A 427 -31.091 -8.494-51.9161.0042.52 A .„

4/0

ATOM 3228 CD LYS A 427 -32.533 -8.595-51.475 1.0044.23 A

ATOM. 3229 CE LYS A 427 -32.699 -8.021-50.071 1.0045.38 A

ATOM 3230 NZ LYS A 427 -31.858 -8.738-49.056 1.0046.31 A

ATOM 3231 C LYS A 427 -28.858-10.703-52.6821.0037.84 A ATOM 32320 LYS A 427 -28.141-10.641-51.6941.0038.04 A

ATOM 3233 N MET A 428 -29.272-11.855-53.193 1.0036.27 A

ATOM 3234 CA MET A 428 -28.892-13.128-52.600 1.0035.94 A

ATOM 3235 CB MET A 428 -29.516-14.275-53.390 1.0037.03 A

ATOM 3236 CG MET A 428 -31.032-14.374-53.271 1.0039.38 A ATOM 3237 SD^" MET A 428 -31.582-14.888-51.610 1.0040.81 A

ATOM 3238 CE MET A 428 -31.204-16.615-51.7041.0039.93 A

ATOM 3239^" C MET A 428 -27.379-13.306-52.5891.0035.66 A

ATOM 3240 O MET A 428 -26.832-14.021-51.758 1.0034.79 A

ATOM 3241 N ALA A 429 -26.701-12.663-53.529 1.0036.32 A ATOM 3242 CA ALA A 429 -25.248 -12L785 -53.628 1.0035.93 A

ATOM 3243 CB .ALA A 429 -24:754-12.221-54.986 1.0037.05 A

ATOM 3244 C ALA A 429 -24.6Θ4 -12.039 -52.476 LOO 34.31 A

ATOM 3245 O ALA A 429 -23 :5S5 -12.465 -51.9191.0033.40 A

ATOM 3246 N LEUA 430 -25.215-10.916-52.1301.0032.90 A ATOM 3247 CA LEU A 430 -24.722-10.091-51.049 1.0032.81 A

ATOM 3248 CB LEU A 430 -25.538 -8,799-50.958 1.0030.19 A

ATOM 3249 GG LEUA-430 -25.357 -7.741 -52:049 1.0028.77 A

ATOM 3250 CDI-LEU A 430 -26.199 -6.524 -51.720 H)O 26.75 A

ATOM 3251 -CD2 LE-U A- 430 -23,897 -JZ.346 -52.1551.0027.83 A ATOM 3252 C LEU A 430 ^24:817 -10X49 -49.7321.0034.30 A

ATOM 3253 O LEU A 430 -24.010 -R1640 -48.823- 1.0034.52 A:

AT©M- 3254 N GLU A 431 -25.807 -11.73.4^" -49.639 1.0035.43 A

ATOM 3255 CA GLU A 431 -26.035-12.514-48.431 1.0035.74 A

ATOM 3256 CB GLU A 43-1 -27.523 -12.866- -48.2871.0036.66 A ATOM 3257 CG GLU A 431 -27.832-13.770-47.0861.0039.76 A

ATOM 3258 CD GLU A 431 -29.324-13.984-46.8401.0040.98 A

ATOM 3259 OEl GLU A 431 -30.123-13.046-47.075 1.0040.56 A

ATOM 3260 OE2 GLU A 431 -29.691-15.092-46.386 1.0041.61 A

ATOM 3261 C GLU A 431 -25.225-13.795-48.353 1.0035.79 A _4yy

ATOM 3262 O GLU A 431 -24.574-14.054-47.3501.0037.93 A

ATOM 3263 N LYS A 432 -25.254-14.600-49.4041.0035.41 A

ATOM 3264 CA LYS A 432 -24.545-15.869-49.3781.0035.37 A

ATOM 3265 CB LYS A 432 -25.326-16.923-50.1761.003.7.67 A ATOM 3266 -CG LYS A 432 -26.824-17.050-49.8491.0040.63 A

ATOM 3267 CD LYS A 432 -27.105 -17.604 -48.4571.0043.26 A

ATOM 3268 CE LYS A 432 -28.606-17.793-48.243 1.0045.87 A

ATOM 3269 NZ LYS A 432 -28.959-18.171-46.8381.0047.58 A

ATOM 3270 C LYS A 432 -23.108-15.83« -49.8851.0034.70 A ATOM 3271 O LYS A 432 -22.235-16.474-49.3071.0035.14 A

ATOM 3272 N TLE A 433 -22.853-15.114-50:9691.0034.15 A

ATOM 3273 CA ILE-A 433 -21.505 -15.074--51.5291.0032.90 A

ATOM 3274 CB ILE A 433 -21.476-14.410-52.9331.0032.52 A

ATOM 3275 CG2 ILE A 433 -20.049-14.440-53.4921.0032.39 A ATOM 3276 -CGl ILE A 433 -22.430-15.145-53.-881 1.0032.67 A

ATOM 3277 CDl ILE A 433 -22.109 -16.632 -54.0821.0033.46 A

ATOM 3278 C ILE A 433 -20.534-14.329-50.643 1.0031,62 A

ATOM 3279 O ILE A 433 -19.456-14.825-50.3271.0031.86 A

ATOM 3280 N ALA A 434 -20.928-13.131-50.2451.00-30.66 A ATOM 3281 CA ALA A 434 -20,093 -12.283 -49.4101.0030.18 A

ATOM 32-82 CB ALA A-434 -20,828-10.974-49.1121.00-30.30 A

A-TOM 3283 C ALA A 434- -19.666 -T2τ942 -48J 021.00-29.70 A

ATOM 3284 O ALA A 434 -18.670 -12.540 -47.4971.0030.11 A

ATOM 3285 N- PHE A 435 -2O425 -13.945 -47.6711:0027.93 A=. ATOM 3286- CA r PHE A 435 -20.151-14.646-46.4261.0026.22 A

ATOM 3287- CB P-HE A-435 -21.447^"-T 5.292 -45.9201J3Θ 26.88 A

ATOM 3288^" CG PHE A 435 -21.310 -15.975 -44.589 k0028.09 A

ATOM 3289 CDl-EHE A 435 -21.428-15.252-43.4071.0027.98 A

ATOM 3290 -CD2 PHE A 435 -21.014-17.332-44.5181.0028.26 A ATOM 3291 CEl PHE A 435 -21.250-15.866-42.1781.0028.66 A

ATOM 3292 CE2 PHE A 435 -20.833-17.952-43.2901.0030.08 A

ATOM 3293 CZ PHE A 435 -20.951-17.213-42.115 1.0029.86 A

ATOM 3294 C PHE A 435 -19.054-15.710-46.560 1.0025.49 A

ATOM 3295 O PHE A 435 -18.218-15.880-45.673 1.0026.09 A _4yg

ATOM 3296 N LEU A 436 -19.053-16.418-47.6781.0024.52 A

ATOM 3297 CA LEU A 436 -18.085-17.479-47.9071.0023.66 A

ATOM 3298 CB LEU A 436 -18.032-17.812-49.395 1.0023.35 A

ATOM 3299 CG LEU A 436 -19.380-18299-49.9191.002X69 A ATOM 3300 CBl-LEUA 436= -19.205-1^"8.825-51.3231.0025.2O A

ATOM 3301 CD2LEUA436 -19.910 -19-404 -49.0221.0022.16 A

ATOM 3302 C LEU A 436 -16.684-17.223-47.3791.0023.03 A

ATOM 3303 O LEU A 436 -16.151-18.024-46.605 1.0022.70 A

ATOM 3304 N PRO-A 437 -16.U57 -16.112 -47.7901.0022.16 A ATOM 3305 CD PRO A 437 -16.486-14.935-48.562 1.0020.38 A

ATOM 3306 CA PRO A 437 -14.716-15.926-47.246 1.0021,38 A

ATOM 3307 CB PRO A 437 -14.309-14.557-47.804 LOO 20.67 A

ATOM 3308 CG PRO A 437 -15.613-13.857-47.998 1.0020.47 A

ATOM 3309 C PRO A 437 -14.715-16.006-45.7071.0021.34 A ATOM 3310 -O PRO A 437 -14.078-16.885-45.135 1.0021.17 A

ATOM 3311 N PHEA43& -15.449-15.112 -45.Q521.0020.48 A

ATOM 3312 CA PHE A 438 -15.518-15.082-43.5921.0021.02 A

ATOM 3313 CB PHE A 438 -16.645-14.143-43.153 1.002430 A

ATOM 3314 CG PHE A 438 -16.657-13.848-41.6741.0026.82 A ATOM 3315 CDl PHE A 438 -15.616-13.131-41.0761.00.28.90 A

ATOM 3316 CD2 PHE A 438 -T7.7K):-14.275- -40.878 1.0026,95 A

ATOM 3317 CEl PHK A 43« -15/63T-T2.849 -39.699 1,003G.06 A

ATOM 3318 CE2-PHEA43.8 -1-7.734-13.999-39.-503 1.0027.62 A

ATOM 3319:÷eZ PHEA 438 -16.694 -13.286 -38.914 L0Θ-2&41 A ATOM 3320 C PHEA438 -15J27 -iότ461-42.95_61.0019.49 A

ATOM 3321 O PHE A 438 -14.908-1-6.909-42.1-55-1,0046.91 A

ATOM 3322 N GLYA.43.9 -1-6.830 -1-7.146 -43.3171.0Θ 18.18 A

ATOM 3323 CA GLY A 439 -17.139 -18.429-42.788 LOO 16.92 A

ATOM 3324- C GLY A 439 -15.942-19.359-428401.0017.89 A ATOM 3325 O GLY A 439 -15.736-20.160-41.9501.0020.24 A

ATOM 3326 N TYR A 440 -15.148-19.273-43.8921.0018.32 A

ATOM 3327 CA TYR A 440 -13.962-20.117-44.0291.0018.45 A

ATOM 3328 CB TYR A 440 -13.420-19.976-45.466 1.0015.98 A

ATOM 3329 CG TYR A 440 -12.298-20.915-45.813 1.0011.99 A _4?9

ATOM 3330 CDl TYR A 440 -12.537-22.273-45.905 1.0010.26 A

ATOM 3331 CEl TYR A 440 -11.523-23.155-46.198 1.0010.92 A

ATOM 3332 CD2 TYR A 440 -10.994-20.447-46.031 1.0010.51 A

ATOM 3333 CE2 TYR A 440 -9.956-21.321-46.327 1.008.89 A ATOM 3334 CZ TYR A 440 -10.228 -22.6S4 -46.40.61.0011.12 A

ATOM 3335 OH TYR A 440 -9.216-23.602 -46J6341.0© 11.47 A

ATOM 3336 C TYR A 440 -12.876-19.682-43.019 1.0019.11 A

ATOM 33370 TYR A 440 -12.379-20.476-42.2181.0018.57 A

ATOM 3338 N LEUA 441 -12.54648.397 -43vO95 hθθ 19.81 A ATOM 3339 CA LEU A 441 -11.536-17.723-42.291 1.0020.54^" A

ATOM 3340 CB LEU A 441 41.6024^:223-42.631 1.0020.9S A

ATOM 3341 CG- LEU A 44-1 -11.25145.054-41.668 1.0021.62 A

ATOM 3342 CDl LEU A 441 -11.307-13.813-42.4481.0023.58 A

ATOM 3343 CD2LEUA441 42.23745.01 l-4(L5081.0023.56 A ATOM 3344 C LEU A 441 -11.540 -17.917-40=7781.00^~20.49 A

ATOM 3345 O LEU A 441 -10.508-18.218-40.1901.0021.16 A

ATOM 3346 N VAL A 442 -12.696-17.747-40.1471.0019.98 A

ATOM 3347 CA VAL A 442 -12.796-17.836-38.698 1.0018.64 A

ATOM 3348 CB VAL A 442 -14.260-17.702-38.248 1. OO 17.04 A ATOM 3349 CGl VAL A 442 -14.382-18.072-36.7801.0015.43 A

ATOM 3350 CG2 VAL A 442 -14.745-X6L261 -38.4S1 1,0014.17 A

AlFOM 3351 G VALA-442 -12.170 -19.061~3K.055- 1.0020.84^" A.

ATOM 335-2 O- VAL A 442 41.25948.939=~37.2301.0021.75 A

ATOM, 3353 N- ASP A 443 -12.645-20,-245-287409 1.0021.56 A ATOM 3354 CA ASP A 443 -12.065 -2 r.425^-37,S091=0022.76 A

Aϊ@M 3355 CB^" ASP A 443 -12.9159 -22.62-4-318,0371.0023.89 A

ATOM 3356 CG- ASPA-443 -13:910 -22,864--36.88J_L0023.96 A

ATOM 3357 ODl ASFA 443 44.315-21.874-36.2171.00-22.48 A

ATOM 3358 OD2ASPA443 -14.237-24.052-36.6591.0024.76 A ATOM 3359 C ASP A 443 -10.672-21.663-38.363 1.0023.39 A

ATOM 3360 O ASP A 443 -9.932-22.514-37.880 1.0025.02 A

ATOM 3361 N GLN A 444 -10.314-20.899-39.381 1.0024.20 A

ATOM 3362 CA GLN A 444 -8.988-21.013-39.968 1.0024.71 A

ATOM 3363 CB GLN A 444 -8.884-20.160-41.2441.0025.46 A ATOM 3364 CG GLN A 444 -9.550-20.758-42.4771.0025.96 A

ATOM 3365 CD GLN A 444 -8.914-22.072-42.851 1.0026.73 A

ATOM 3366 OEl GLN A 444 -7.697-22.152-43.0501.0027.45 A

ATOM 3367 NE2GLNA444 -9.724 -23.L17 -42.938 1.0025.73 A

ATOM 3368 C GLN A 444 -8.096-20.439-38.8861.00^" 24.19 A

ATOM 3369 O GLN A 444 -7.092-21.023-38.493 1.0024.29 A

ATOM 3370 N TRP A 445 -8.505-19.280-38.396 1.0024.30 A

ATOM 3371 CA TRP A 445 -7.786-18.571-37.352 1.0024.84 A

ATOM 3372 CB TRPA44T -8.502-17.255-37.0421.0025.62 A

ATOM 3373 CG TRP A 445 -7.927-16.507-35.883 1.0026.83 A

ATOM 3374 CD2 TRE A 445 -8.440-16.476-34.543 1.0028.17 A

ATOM 3375 CE2TRPA445 -7.552-15.696-33.773 LOG 27.58 A-

ATOM 3376 CE3TRPA445 -9.565-17.033-33.920 1.0028.75 A

ATOM 3377 CDl TRP A 445 -6.784-15.762-35.871 1.0026.63 A

ATOM 3378 NEl TRP A 445 -6.551-15.274-34.608 1.0027.53 A

ATOM 3379 CZ2TRPA445 -7.751-15.459-32.413 1.0027.60 A

ATOM 3380 CZ3 TRP A 445 -9.763-16.796-32.5641.0028.45 A

ATOM 3381 CH2 TRP A 445 -8.859-16.016-31.828 1.0028.74 A

ATOM 3382 C TRP A 445 -7.715-19.422-36.0871.0025.09 A

ATOM 3383 O TRP A 445 -6.6J8 -19,589 -35.4981.0024.69 A

ATOM 3384 R ARG A 446 -8.865-19.954-35^675 1.0024.13 -A

ATOM 3385 CA -ARG A 446 -8.919 -20.77:6. -34.47S LOO 23.55 A

ATOM 3386 CB- ARG A-446 -10.351-21.104-34.099 Lθθ 2L69 A

ATOM. 33-87^" CG AR=G A-446 -JΩ.934 -20-101 -3372001.0020.00 Λ

ATOM 338SlCD ARGA.446 -12.094 -20.668-32.489- 1.0020.9.1 A

ATOM 3389^' ME ARG A 446 -13-322 -20.581-33.2581:0023.43 A

ATOM 3590. CZ ARG A 446 -14.506 -20.382 -32.76S" 1.0025.29 A

ATOM 3391 NHl ARG A 446 -1-4.582-20.261-3-1.398 l.OΘ 28.61 A

ATOM 3392 NH2ARGA446 -15.588-20.276-33.4601.00.25.58 A

ATOM 3393 C ARG A 446 -8.150-22.062-34.455 1.0024.22 A

ATOM 3394 O ARG A 446 -7.442-22332-33.4941.0026.11 A

ATOM 3395 N TRP A 447 -8.286-22.879-35.4871.0023.90 A

ATOM 3396 CA TRP A 447 -7.558-24.135-35.455 1.0023.53 A

ATOM 3397 CB TRP A 447 -7.688-24.907-36.7701.0026.85 A j

ATOM 3398 CG TRP A 447 -9.063-25.346-37.1031.0029.56 A

ATOM 3399 CD2 TRP A 447 -9.564 -25.596 -38.4121.0031.72 A

ATOM 3400 CE2 TRP A 447 -10.913-26.002-38.2741.0033.10 A

ATOM 3401 CE3TRPA447 -9.003-25.515-39.6941.0031.91 A ATOM 3402 CDl TRP A 447 -10:089-25.602-36.2391.0030.05 A

ATOM 3403 NEl TRP A 447 -1T.2T0 -25.997 -36.9361.0031.31 A

ATOM 3404 CZ2 TRP A 447 -11.714 -26.326 -39.3781.0034.13 A

ATOM 3405 CZ3 TRP A 447 -9.794-25.835-40.791 1.0034.11 A

ATOM 3406 CH2 TRP A 447 -Ϊ1.140 -26.235 -40.625 1.0034.69 A ATOM 3407 C TRP A 447 -6.091-23.839-35.1741.0021.52 A

ATOM 3408 O TRP A 447 -5.375 -24.654 -34592 1.0020.05 A

ATOM 3409 N GLY A 448 -5.661-22.644-3.5.561 1.0020.39 A

ATOM 3410 CA GLY A 448 -4.277-22.250-35.363 1.0019.59 A

ATOM 3411 C GLY A 448 -3.958-21.723-33.983 1.0018.09 A ATOM 3412 O GLY A448 -2.801 -21.762-33.544 -1.0016.29 A

ATOM 3413 N VAL A 449 -4.977-21.193-33.3181.0016.98 A

ATOM 3414 CA VAL A 449 -4.807-20.701 -3 L965 1.0017.33 A

ATOM 3415 CB VAL A 449 -5.998-19.862-31.4991.0018.19 A

ATOM 3416 CGl VAL A 449 -5.875-19,594-30.001 1.0017.73 A ATOM 3417 CG2 VAL A 449 -6.050 -1S.551 -32.2851.0019.06 A

ATOM 3418 C VAL A 449 -4.724-21.923-31.0771.0016.04 A

ATOM 3419 O -VAL A 449 -3.858=22.016-39.229 1.0017.18 A

ATOM 3420 N PHE A 450 -5.647 -22..85Θ -3L2881,0015.46 A

ATOM 3421 CA PHE A 450- -5.1X2 -24.103 -30.5441.0014.62 A ATOM 3422 CB BHELA 45Θ- -6^925 -24.927 -3 Θτ979 kθO 13.13 A

ATOM 3423 CG PHEIA 450 -^"8L216 -24.514-30.3381.0Θ-L2.52^" A ATOM- 3424 CDl PHE A 450 -9.382^4.450-31.0911.0012.24- A

ATOM 3425 CD2 PHE A 450 -8.280 -24.215 -28.981 1.0012.8S A

ATOM 3426 CEl PHE A 450 -10.597 -24.094--30.503 1.0012.74 A ATOM 3427 CE2 PHE A 450 -9.488-23.858-28.3901.0012.88 A

ATOM 3428 CZ PHE A 450 -10.645-23.798-29.1501.0011.88 A

ATOM 3429 C PHE A 450 -4.482-24.969-30.7571.0019.32 A

ATOM 3430 O PHE A 450 -4.142-25.796-29.915 1.0021.34 A

ATOM 3431 N SERA 451 -3.826-24.793-31.8921.0021.35 A ATOM 3432 CA SERA 451 -2.655-25.587-32.2071.0022.82 A

ATOM 3433 CB SER A 451 -2.646-25.914-33.698 1.0023.79 A

ATOM 3434 OG SERA 451 -1.970-24.918-34.4621.0025.10 A

ATOM 3435 C SERA 451 -1.352-24.891-31.832 1.0023.99 A

ATOM 3436 O SERA 451 -0.296 -25.503 -31.8071.0024.29 A

ATOM 3437 N GLY A 452 -1.402-23.601-31.5601.00^"2532 A

ATOM 3438 CA GLY A 452 -0.163-22.934-31.1961.0028.81 A

ATOM 3439 C GLY A 452 0.477-22.202-32.3621.0030.57 A

ATOM 3440 O GLY A 452 IA9T-21.522 -32.2261.0029.86 A

ATOM 3441 N ARG A 453 -0.176-22.304-33.5061.0032.86 A

ATOM 3442 CA ARG A 453 OJOl -21.643 -34.6941.0035.6£ A

ATOM 3443 CB ARG A 453 -0J646 -21.963 -35.863 1.0038.68 A

ATOM 3444 CG ARG A 453 -0.148-21.496-37.2171.0041.90 A

ATOM 3445 CD ARG A 453 -1.288-20.977-38.080 L00-44.16 A

ATOM- 3446 NE ARG A 453 -1.877-21.986-38.9591.0047 J9 A

ATOM- 3447 CZ ARG A 453 -3.183-22.232-39.038 1.0050.00 A

ATOM 3448 NHl ARG A 453- -4.03J6 -21.542 -38.2881.0051.34 A

ATOM 3449 NH2ARGA453 -3.644-23.165-39.860 1.0051.40 A

ATOM 3450 C ARG A 453 0.244-20.184-34.3661.0035.09 A

ATOM 3451 O ARG A 453 1.166-19.416-34.633 1.0035.74 A

ATOM 3452 N THR A 454 -0.866-19.822-33.7491.0034.12 A

ATOM 3453 GA THR A 454 -1. LOS -1-8.435~33.391- 1.0033.76 A

ATOM 3454 CB THR A 454 -2.381 -17.959 -34.1101.0034.48 _A

ATΘM 3455 OGl T-HRA.454 -2.180-18.095-35.5221.003.7.25 A

ATOM 3456 CG2 THRA-454 -2.714-16.511 ,33.775 1.0035τ67 ^

ATOM 3437 C THRA 454 -1.227 -18.152 -3 l.«881.0033J36- A

ATOM 3458 O THR-A 454 -2.323-18.167-3-1.325 1.0034.76 A

ATOM 3459 N PRO A 455 -0.096-17.877-31.218 1.0031.46 A

ATOM 3460 CD PRO A 455 1.257-17.791-31.784 1.0031.95 A

ATOM 3461 CA PRO A 455 -0.069-17.583-29.783 LOO 30.57 A

ATOM 3462 CB PRO A 455 1.421-17.564-29.471 1.0030.93 A

ATOM 3463 CG PRO A 455 1.997-17.025-30.7121.0030.59 A

ATOM 3464 C PRO A 455 -0.734-16.239-29.523 1.0029.76 A

ATOM 3465 O PRO A 455 -0.959-15.463-30.4491.0030.74 A ATOM 3466 N PRO A 456 -1.063-15.939-28.2601.0028.59 A

ATOM 3467 CD PRO A 456 -0.952-16.750-27.035 1.0028.22 A

ATOM 3468 CA PRO A 456 -1.708-14.649-27.9741.0026.49 A

ATOM 3469 CB PRO A 456 -1.838-14.675-26.4591.0027.81 A - ATOM 3470 CG PRO A 456 -2.027-16.149-26.1691.0027.76 A

ATOM 3471 C PRO A 456 -0.855-13.489-28.4671.0023.88 A

ATOM 3472 O PRO A 456 -1.295-12.351-28.5771.0023.44 A

ATOM 3473 N SER A 457 0.393-13.828-28.7341.0020.98 A

ATOM 3474 CA SER A 457 1,407-12.916-29.233 1.0018.1* A

ATOM 3475 CB SERA457 2.755-13.641-29.1361.0016.89 A

ATOM 3476 OG SERA 457 3.622-13.304-30.183 LOO 19.22 A

ATOM 3477 C SER A 457 1.117-12.4-51-30.683 1.0018.18 A

ATOM 3478 O SER A 457 1.715-11.489-31.191 1.0018.53 A

ATOM 3479 N ARG A 458 0.182-13.139 -31.336.1.0017.03 A - ATOM 3480 CA ARG A 458- -0.194-12.860-32.727 LΘO 15.25 A

ATOM 3481 CB ARG A 458 0.521-13.814-33.6921.0012.78 A

ATOM 3482 CG ARG A 458 2.036-13.705-33.662 1.0012.10 A

ATOM 3483 CD ARG A 458 2.661-14.542-34,7471.0010.80 A

ATOM 3484 NE ARG A 458 3.928-15.131-34.334 1.006.37 A

ATOM 3485 CZ ARG A 458 4.097-16.427-34.133 1.006.59 A

ATOM 3486 NHlARG A 458 3.078-1-7.268-34.294 1.008.02 A

ATOM 3487 NH2 AKG-A 458 5.293 -16.89Θ -333171,007.02 A

AT-OM 3488 C ARG A 458 -1.679-13.014-32.9521.0015.24 A

ATOM 34:8.9 O ARG A 458 -2.103 -13.249--34:0fi5: 1700-4-4.38 A ^" ATOM 3490^" N TYR A- 459 -2.467-127899-31.893^" 1.00-16.14 A

ATOM 3491 GA TYRA 459 -3.910-13.025-32.018 LOQ 15τ97 A

ATOM 3492 CB TYR A 459- -4.606-12:802-30:662- 1.0018.56 A

ATOM 3493 CG TYR A 459 -4.730-14.024-29.769 1.0020.75 A

ATOM 3494 CDl TYR A 459 -5.562-14.003-28.655 LOO 21.39 A ^" ATOM 3495 CEl TYR A 455 -5.678-15.104-27.817 1.0022.61 A

ATOM 3496 CD2TYRA459 -4.007-15.190-30.0241.0022.04 A

ATOM 3497 CE2TYRA459 -4.114-16.301-29.190 1.0022.44 A

ATOM 3498 CZ TYR A 459 -4.954-16.247-28.0841.0023.41 A

ATOM 3499 OH TYRA459 -5.072-17.329-27.2371.0024.19 A ATOM 3500 C TYR A 459 -4.497-12.041-33.0301.0015.14 A

ATOM 3501 O TYRA 459 -5.263-12.432-33.9001.0016.78 A

ATOM 3502 N ASN A 460 -4.156-10.764-32.9301.0012.60 A

ATOM 3503- CA ASN A 460 -4.744 -9.807-33.846 1.0011.06 A ATOM .3504 CB ASN A 460 -4.787 -8.427-33.212 1.007.19 A

ATOM 3503^" CG ASN A 460 -6.108 -7.713 -33.4671.005.16 A

ATOM 3506 ODl ASN A 460 -7.193 -8.280-33.2601.001.00 A

ATOM 3507 ND2ASNA460 -6.026 -6.461 -33.9161.005.44 A

ATOM 3508 C ASN A 460 -4.003 -9.7.56 -35.1691.0013.05 A ATOM 3509 O ASN A 460 -4.604 -9.573-36.2251.0011.98 A

ATOM 3-510 N PHEA46T -2.692 -9.930 -35.1091.0014.60 A

-ATOM 3511 CA PHEA 461 -1.884 -9.916-36.311 1.0014.20-. A

ATOM 3512 CB PHE A 461 -0.416 -9.946 -35.9321.0014.64 A

ATOM 3513 CG PHE A 461 0.498 -10.326 -37.043 1.0014.77 A ATOM 3514 CDl PHE A 461 0,892-11.635-37.1901.0016.65 A

ATOM 3515 CD2PHEA461 1.042 -9.366 -37.883 J.0O 16.09 A

ATOM 3516 CEl PHE A 461 1.819-11.991 -38.1441.0017.35 A-

ATOM 3517 CE2 PHE A 461 1.974 -9.71S -38.8441.0015.79 A

ATOM 3518 CZ PHEA 461 2.365 -11.028 -35.975 1.0015.89 A ATOM 3519 C PHE A 461 -2.231-11.067-37.231 1.0.014.65 A

ATOM 2520- O PHE A 461 -2.152-10.912-38.4421.0017.34 A

AT-QM 3521 N ASPΑ-462 -2.619^' -12.217 -36.685 IJOO .13.53 A

AT-QM 1522 CA ASP A 462 -2.-990 -13.341 -3.7.5441:0012.23 A

ATOM 3523 CB ASP A 462 -2.666-14:7-02-36.886 l.Oθ-ir.68. A ATOM- 3524 CG ASP-A- 462 -L238 -15.154 -37.1601.0010.89 A

ATOM 3525 ODl ASP-A 4^2 -0:550 -14.444 -37.915- 1.0010.88^" A ATΘM_3J526 QD2 ASP A-462 -0τ794 -46:200 -36.635 LOG 9.26 A

ATOM 3527 C ASPA 462 -4.474 -13.273 -37.9191.0.012.15 A

ATOM 3528 O ASPA462 -4.926-13.932-38.856 LOO 13.04 A ATOM 3529 N TRP A 463 -5237 -12.466 -37.199 Ii)O 11.67 A

ATOM 3530 CA TRP A 463 -6.653-12.343-37.510 1.0011.56 A

ATOM 3531 CB TRP A 463 -7.414-11.770-36.303 1.005.52 A

ATOM 3532 CG TRP A 463 -8.864-11.347-36.522 1.00 1.82 A

ATOM 3533 CD2 TRP A 463 -10.019-12.196-36.568 1.001.00 A ATOM 3534 CE2TRPA463 -11.154-11.354-36.6851.00 1.00 A ATOM 3535 CE3TRPA463 -10.208-13.585-36.515 1.001.00 A ATOM 3536 CDl TRP A 463 -9.336-10.064-36.6201.001.00 A ATOM 3537 NEl TRP A 463 -10.706-10.063-36.711 1.001.00 A ATOM 3538 CZ2 TRP A 463 -12.455-11.850-36.753 1.001.00 A ATOM 3539 CZ3 TRP A 463 -11.510-14.087-36.^"582,IvOO l.Oσ A ATOM 3540 CH2 TRP A 463 -12.616-13.217-36.7001.001.00 A ATOM 3541 C TRP A 463 -6.799-11.448-38.725 1.0012.78 A ATOM 3542 O TRP A 463 -7.527 -11.781 ^39.634- l.θθ 14.39 A ATOM 3543 N TRPA464 -6.105 -10.316 -38.7441.0015.15 A ATOM 3544 CA TRP A 464 -6.206^" -9.415-39*85 r.OO 17.34 A ATOM 3545 CB TRPA.46-4 -5.767 -8.000-39.493 l.Ofl 17.19 A ATOM 3546 CG TRP A 464 -6.809 -7.354 -38.6801.0019.86 A ATOM 3547 -CD2 TRP A 464 -8.027 -6.782-39.1671.0021.59 A ATOM 3548 CE2TRPA464- -8.788 -6.406-38.0421.0022.7-1 A ATOM 3549 CE3TRPA464 -8.552 -6.555-40.4491.0022.13 A ATOM 3550 CDl TRP A 464 -6.-873 -7.298-37.3201.0020.38- A ATOM 3551 NEl TRP A 464 -8.060 -6.734 -36.9271.0021.44 A ATOM 3552 CZ2TRPA464 -10.057 -J.81Θ -38.160 1.0023.83 A ATOM 3553 CZ3TRPA464 -9.809 -5.963-40.5661.0022.49 A ATOM 3554 CH2 TRPA 464 -10.547 -5.597-3-9.428 1:0022,10 A ATOM 3555 C TRP A 464 -J.432 -9.939-41.107 LOO 18,81 A, ATOM 31556- -O TRP A 464 -5.616_ -9.459-42.236 lJCUM-7.74 A ATOM^" 3557 N TYRA-465 -4.5-66-10.927-40.8871,0018.06 A ATOM 3558 CA TYR A 465 -37864-11.508-42:009 LOO 16.13 A ATOM 3559" GB TYR-A 465 -2.807 -12.505 -41.5521.00: 17.53 A- ATOM 3560 CG TYR A 465 -23Λ8.-13.356 -42.6841.0018:90 A ATOM 3561 CDJ TYR A 465 -1.404 -T2.850 -43.606 LOO 19.33 A ATOM 3562 -CEl TYRA 465 -1.013-13.599-44.7421.0021.94 A ATOM 3563 CD2TYRA465 -2.811 -14.640 -42.8871.0019.93 A ATOM 3564 CE2TYRA465 -2.434-15.401-43.993 1.0021.44 A ATOM 3565 CZ TYR A 465 -1.534-14.877-44.9071.0022.21 A ATOM 3566 OH TYR A 465 -1.182-15.623-46.019 1.0022.78 A ATOM 3567 C TYR A 465 -4.977-12.247-42.732 1.0014.99 A ATOM 3568 O TYR A 465 -5.214 -12.030 -43.913 1.00 16.30 A

ATOM 3569 N LEU A 466 -5.683 -13.110 -42.009 1.00 13.62 A

ATOM 3570 CA LEU A 466 -6.769 -13.887 -42.596 1.00 12.40 A

ATOM 3571 CB LEU A 466 -7.320 -14.886 -41.578 1.00 10.65 A

ATOM 3572 CG LEU A 466 -6L293 -15.912 -41.095 l.θθ 9.26 A

ATOM 3573 CDl LEU A 466 -6.948--16.871 -40.147 1.00 10.69 -A

ATOM 3574 CD2 LEU A 466 -5.732 -16.667 -42.272 1.00 11.43 A

ATOM 3575 C LEU A 466 -7.906 -13.055 -43.173 1.00 12.66 A

ATOM 3576 O LEU A 466 -8.405^"-13.351 -44.259 1.^"OO 14,43 A-

ATOM 3577 N ARG A 467 -8318 -12.015 -42.461 1.00 12.47 A

ATOM 3578 CA ARG A 467 -9.400 -11.154 -42.926- 1.00 13.22 A

ATOM 3579 CB ARG A 467 -9.740-10.115 -4L860 1.00 11.28 A

ATOM 3580 CG ARG A 467 -10.212 -10.711 -40.537 1.00 11.58 A

ATOM 3581 CD ARG A 467 -11.736 -10.796 -40.432 1.00 931 A

ATOM 3582^" NE ARG A 467 -12.336 -9.467 -40.439 1.00 7.8-5 A

ATOM 3583 CZ ARG A 467 -13.633 -9.233 -40.289 1.00 7.41 A

ATOM 3584 NHl ARG A 467 -14.099 -7.991 -40.310 1.00 1027 A

ATOM 35.85 NH2 ARG A 467 .14.467 -10.241 -40.120 1.00 5.26 A

ATOM 3586 C ARG A 467 -9.029 -10.453 -44.238 1.00 15.47 A

ATOM 3587 O ARG A 467 -9.783 -10.507 -45.210 1.00 16.05 A

ATOM 3588 N THR A 468 -7.882 -9.778 -44.2€4 1.00 15.89 A-

ATOM 3589- CA THR A 468. -74459 -9-107 -45.481 1.00 15;95- A

ATOM 3590 CB THR A 468 -6.0Z0 -8^33-45.316 hθθ-1-5.49 A

ATOM 3591 OG1 THRA=468 -6.199 -7.271 -44489 1.00113.79 A T ATΘM 3592 CG2 THRA 468 -5.492 -8.020 -46.689 1=00 15:S8 A

ATOM 3593-C TfM. A 468 -7.385 -10rl81 -^"46.563 LOO 17.63 A

ATOM 3594 O^' THR A 468 -8τO77 -10.123 -47.585 l;00i*.37 A

ATOM 3595 N LYS A 469 -6,576 -11.1:92.-46.288 1.00 17.49 A

ATOM 3596 CA LYS A 469 -6.390 -12.284 -47.223 1.00 16.47 A

ATOM 3597 CB LYS A 469 -5.508 -13.355 -46.600 1.00 16.06 A

ATOM 3598 CG LYS A 469 -5.470 -14.569 -47.453 1.00 12.08 A

ATOM 3599 CD LYS A 469 -4.291 -15.410 -47.152 1.00 10.90 A

ATOM 3600 CE LYS A 469 -4.705 -16.829 -47.389 1.00 9.92 A

ATOM 3601 NZ LYS A 469 -3.593 -17.719 -47.793 1.00 11.17 A _4g?

ATOM 3602 C LYS A 469 -7.621-12.948-47.811 1.0015.94 A

ATOM 3603 O LYS A 469 -7.617-13.354-48.953 1.0017.82 A

ATOM 3604 N TYR A 470 -8.683-13.094-47.049 1.0015.53 A ATOM 3605 CA TYR A 470 -9.853-13.725-47.641 1.0016.43 A ATOM 3606 CB TYR A 470 -10.423 -14.848 -46.765 1.0015-10 A ATOM 3607 CG TYR A 470 -9.549-16.077-43.7221.0015.38 A ATOM 3608 CDl TYR A 470 -8.519-16.193-45.795 1.0016.14 A ATOM 3609 CEl TYR A 470 -7.690-17.317-45.7761.0015.38 A ATOM 3610 CD2 TYR A 470 -9..73U -17.111 -47.6261.0013.62 A ATOM 3611 CE2TYRA470 -8.910-18.230-47.6141.0013.00 A ATOM 3612 CZ TYR A 470 -7.896 -18.33Z --46.6941.0013.73 A ATOM 3613 OH TYR A 470 -7.099-197451-46.698 1.0013.03 A

ATOM 3614 C TYR A 470 -10.957-12.764-47.990 1.0018.01 A

ATOM 36150 TYR A 470 -11.547-12.875-49.049 1.0021.96 A ATOM 3616 N GLNA 471 -11.234-11.800-47.131 1.0018.10 A ATOM 3617 CA GLNA 471 -12.307-10.872-47.431 1,0017.57 A ATOM 3618 -CB GLN A 471 -13.028-10.481-46.145 1.0020.48 A ATOM 3619 CG GLN A 471 -13.981-11.568-45.613 1.0022.42 A ATOM 3620 CD GLNA471 -14.715-11.153-44.335 1.0022.68 A ATOM 3621 OE1GLNA471 -14.116-11.074-43.2701.0021.86 A ATOM 3622 NE2 GLN A 471 -16.015-10.877-44.449 1.00_^22.86 A

ATOM 3623 C GLN A 471 -11.873-9.626-48.180 LOO 16.77 A

ATOM 3624-O GLNA_471 -J2.687- -8.972 -4Sτ8321.00-1-5.24 A-

ATOM 3625 N GLY A 472 -10.594 -9.291 -48.095- LOO 16700 A ATOM 3626 CA GLYLA.472 -KLH6- -8.11-1 -48.788 1.0015.14 A

ATOM= 3627 C SLY A 472 -10.717 --&S-9β--48.1501.0045.67 A

ATOM 3628- O GLY A 472 -11:23.7 -57979-48.803 1,0014.72 A

ATOM- 3629 N ILE A 473 -10.670 -6.908-46.8271.0016.88 A

ATOM 3630 CA ILE A 473 -11.140 -5.-797-46.0281.0014.85 A ATOM 3631 CB ILE A 473 -12.392 -6.-161-45.2651.0014.40 A

ATOM 3632 CG2 BLE A 473 -13.479 -6.499-46.2461.0013.67 A

ATOM 3633 CGl ILE A 473 -12.110 -7.338-44.3291.0015.74 A

ATOM 3634 CDl ILE A 473 -13.213 -7.608-43.298 1.0014.84 A

ATOM 3635 C ELE A 473 -10.029 -5.441-45.055 1.0013.85 A ATOM 3636 O ILE A 473 -9.188 -6.276-44.7001.0011.70 A

ATOM 3637 N CYS A 474 -10.003 -4.186-44.6491.0013.50 A

ATOM 3638 CA CYS A 474 -8.989 -3.751-43.709 1.0013.97 A

ATOM 3639 CB CYS A 474 -7.911 -2.939-44.4271.0013.11 A ATOM 3640 SG CYS A 474 -8.539 -1.394-45.1101.0015.19 A

ATOM 3641 C CYS A 474 -9.669 -2.920-42.6241.0013.03 A

ATOM 3642 O CYS A 474 -10.761 -2.400-42.8241.0014.32 A

ATOM 3643 N PROA475 -9.036 -2.811-41.453 1.0012.11 A

ATOM 3644 CD PRO A 475 -7.731 -3.434-41.1721.0012.64 A ATOM 3645 CA PRO A 475 -9.519 -2.071-40.291 1.0010.95 A

ATOM 3646 CB PRO A 475 -8.554 -2.504-33.2041.0012.89 A

ATOM 3647 CG PRO A 475 -7.273 -2.684-39.9721.0013.37 A

ATOM 3648 C PRO A 475 -9.480 -0.581-40.541 1.0010.84 A

ATOM .1649 O PRO A 475 -8.484 -0.062-41.015 1.0010.74 A ATOM 3650 N PRO A 476 -10J72 0.127-40.231 1.0010.75 A

ATOM 3651 CD PRO A 476 -11.867 -0.428-39.821 1.0011.55 A

ATOM 3652 CA PRO A 476 -10.672 L574 -40.4241.0010.83 A

ATOM 3653 CB PRO A 476 -12.151 1.860-40.1861.0010.74 A

ATOM 3654 CG PRO A 476 -12.56€ 0J92 -39.2841.0012.75 A ATOM 3655 C PRO A 476 -9.759 2.421-39.555 1.0011.53 A

ATOM 36560 PRO A 476 -9.447 3.551-39.921 1.0014.06 A

ATOM 3657 N VAL A 477 -9.348 1.889-38.405 1.0010.78 A-

ATOM 3658 CA VAb A 477 -8-426 2.585-37.498 1.00 U0.09 A

ATΘM_3659 CB VALA477 -9.090 2.941 -3671621.009.90- A ATOM 3660 CGl VAL A 477 -10.146 4.034--36.3.671.00-10L32 A

ATOM 3661 CG2 VAL K 477 -9.728 1.695-35.565^" 1.0011.83 A-

ATOM 3J662 C VAL A 477 -7.290 1:602-37.244 LOO-IO-OS^" A

ATOM 3663 O VAL A 477 -7.440 0.408-37.4841.009.86^" A

ATOM 3664 N THR A 478 -6.153- 2.086-36.7661.009.52 A ATOM 3665 CA THR A 478 -5.017 1.200-36.5241.009.54 A

ATOM 3666 CB THR A 478 -3.765 2.004-36.1491.007.53 A

ATOM 3667 OGl THR A 478 -3.582 3.066-37.093 1.008.73 A

ATOM 3668 CG2 THR A 478 -2.537 1.116-36.1601.006.75 A

ATOM 3669 C THRA478 -5.294 0.204-35.411 1.0011.61 A _m

ATOM 3670 O THR A 478 -6.118 0.467-34.5201.0013.58 A

ATOM 3671 N ARGA479 -4.614 -0.941-35.4581.0011.11 A

ATOM 3672 CA ARG A 479 -4.781 -1.962-34.4191.0012.13 A

ATOM 3673 CB ARG A 479 -5.649 -3.115-34.9161.0010.92 A ATOM 3674 CG ARG A 479 -6.742 -2.716-35.881 1.0012.59 A

ATOM 3675 CD ARG A 479 -7:805 -1.897-35.2241.0010.46 A

ATOM 3676 NE ARG A 479 -8.543 -2.666-34.2341.0011.97 A

ATOM 3677 CZ ARGA479 -9.036 -2.137-33.1261.0011.03 A

ATOM 3678 NHl ARG A 479 -8.859 -0.850-32.8721.009.89 A ATOM 3679 NH2 ARG A 479 -9.715 -2.889-32.2891.0010.98 A

ATOM 3680 C ARG A 479 -3.435 -2.554-33.989 1.0013.30 A

ATOM 3681 O ARG A 479 -2.455 -2.457=34.712 1.0013^40 A

ATOM 3682 N ASN A 480 -3.394 -3.153-32.8001.0014.80 A

ATOM 3683 CA ASN A 480 -2.-151 -3.827-32.3021.0016.87 A ATOM 3684- CB- ASN A 480 -1.328 -2.930-31.4491.0019J07 A

ATOM 3685 CG ASN A 480 -2.082 -1.813-30.915 1.0023.39 A

ATOM 3686 ODl ASN A 480: -3.072-1.999-30.2161.0025.39^" A

ATOM 3687 ND2 ASNA 48fl -1.657 -0.605-31.268 1.0026.41 A

ATOM 3688 C ASN A 480 -2.524 -5.012 -31.4591.00- 1£82 A ATOM 3689 O ASN A 480 -3.684 -5.302-31.1721.0016.76 A

ATOM 3690 N GLU A481 -1.477 -5.692-31.0241.0017.43 A

ATOM 3591 CA GLU A- 481 -1.705 -6.842=30.183 fcθO 19.57- A

ATOM J692-CB GLU A 481 -0.448 -7 '.678 -29fc9721.001117 A-

-ATOM 3693 GG GLUA481 -QJ3S8 -8.544-31.135 1.0020.36 A ATOM 3694 CD GLU A 481 -1292 -9,332-34.6841.-0021.87 A ATOM^" 3695 OEl GEU- A 481 - 1.174 -9.812 -32.825 h0023:07 A

ATOM 3696 ΘE2GLUA481 -2.33-1 -9.478-30.9961.0024.73 A

ATOM 3697 C GLU A 481 -2.190 -6.416-28.805 1.0021.24 A

ATOM 3698 O GLU A 481 -1.626 ,6.833-27.8221.0022.84 A ATOM 3699 N THR A 482 -3.207 -5.583-28.698 1.0021.24 A

ATOM 3700 CA THRA 482 -3.675 -5.259-27.353 1.0020.68 A

ATOM 3701 CB THR A 482 -3.398 -3.852-26.883 1.0022.03 A

ATOM 3702 OGl THR A 482 -4.625 -3.272-26.4381.0025.45 A

ATOM 3703 CG2THRA482 -2.864 -3.020-27.9761.0023.49 A _49Q

ATOM 3704 C THR A 482 -5.114 -5.325-27.641 1.0019.20 A

ATOM 3705 O THR A 482 -5.977 -5.092-26.818 1.0020.34 A

ATOM 3706 N HIS A 483 -5.337 -5.611-28.8971.0018.43 A

ATOM 3707 CA HIS A 483 -6.650 -5.700 -29.4181.0014.78 A ATOM ^~3708 CB HIS A 483 -6.688 -4.955 -30.703 1.0017J6 A

ATOM 3709 CG HIS A 483 -6.532 -3.495-30.515 1.0020.24- A

ATOM 3710 CD2HISA483 -7.380 -2.594-29.9681.0021.11 A

ATOM 3711 NDl HIS A 483 -5.439 -2.784-30.963 1.0021.93 A

ATOM 3712 CEl HIS A 483 -5τ627 -1.501 -30.705 1.0021.87 A ATOM 3713 NE2HISA483 -6.795 -1.360 -30.103 1.0021-19 A

ATOM 37T4 C HS A 483 -7.014 -7.107-29.623 1.0012.07 A

ATOM 3715 Θ HIS A 483 -6.174 -7.996-29.6821,008.57 A

ATOM 3716 N PHE A 484 -8.299 -7.317-29.7341.0011.90 A

ATOM 3717 CA PHE A 484 -8.746 -8.644-29.914 1.0014.17 A ATOM 3718 -CB PHE A 484 -8.974 -9,262-28.5821.0017.91 A

ATOM 3719 CG PHE A 484 -9.104 -1-0.702 -28.667 LOO 21.52 A

ATOM 3720 CDl PHE A 484 -8.171-11.419-29.4141.0021.02 A

ATOM 3721 CD2PHEA484 -10.118-11.366-27.9871.0023.17 A

ATOM 3722 CEl PHE A 484 -8.225-12.795-29.499 1.0019.93 A ATOM 3723 CE2PHEA-484 -10.202-12.757-28.047 LOO 23.43 A

ATΘM 3724 CZ PHE A 484 -9.237-13.481-28.8121.00^22.20 A

ATOM 3725 C PHE A 484 -10.008- -8.5.80 -30.680- 1.0015.12 A

ATOM 372J6 O PHE A 484 -11.091 -8.753-30.1401.0014.80 A

ATOM 3727 N ASPtA 485 -9.855 -8S39 -31373 LOO 15.95- . A - ATOM- 3728 CA ASP A 485 -10.998 -8.180 -32.831 LOO 12.53. A.

ATOM 3729. CB- ASP A-485 -10.53:9 -7,421 -34.060 l.Oθ 12.53 A

ATOM -3730 CG ASP A-485 -9.903 -6.093 -33.6S8 LOQ 11.90 A

ATOM 373-1-ODl ASPA485 -10.586 -5.288-33.025 1.0011.41 A

ATOM 3732 OD2ASPA485 -8.73-1 -5.853-34.045 1.0011.57 A ATOM 3733 C ASPA485 -11.709 -9.484-33.1241.0011.25 A

ATOM 3734 O ASP A 485 -12.899 -9.481-33.4221.009.78 A

ATOM 3735 N ALA A 486 -10.999-10.602-32.9991.0010.42 A

ATOM 3736 CA ALA A 486 -11.640-11.896-33.2141.0013.14 A

ATOM 3737 CB ALA A 486 -10.618-13.017-33.1891.0010.24 A ATOM 3738 C ALA A 486 -12.664-12.104-32.0991.0016.37 A

ATOM 3739 O ALA A 486 -13.722-12.718-32.301 1.0018.80 A

ATOM 3740 N GLY A 487 -12.346-11.567-30.923 1.0017.72 A

ATOM 3741 CA GLY A 487 -13.232-11.699-29.7891.0017.26 A ATOM 3742 C GLY A 487 -14.5O7 -10.881 -29.8601.0018.12 A

ATOM 3743 O GLYA-487 -15.412.-11.085-29.0441.0018.35 A

ATOM 3744 N ALA A 488 -14.604 -9.959-30.8141.0018.65 A

ATOM 3745 CA ALA A 488 -15.809 -9.138-30.9091.0019.99 A

ATOM 3746 CB ALA A 488 -15.501 -7.786-31.5401.0018.39 A ATOM 3747 C ALA A 488 -16.879 -9.833-31.7021.0021.31 A

ATOM 3748 O ALA-A 488 -17;937 -9.258-31.9381.0021.92 A

ATOM 3749 N LYS A 489 -16:612 -1L068 -32.115- 1.0022.31 A

ATOM 3750 CA LYS A 489 -17.605-11.869-32.821 1.0023.96 A

ATOM 3751 CB- LYS A 489 46.961-12.608-33.9961.0025.41 A ATOM 3752 CG LYS A 489 -17.9O7 -13.541 -34.7361.0025.44 A

ATOM 3753 CD LYS A 489 -19.031-12.769-35.4081.0027.23 A

ATOM 3754 CE LYS A 489 -20.095-13.707-35.9541.0027.60 A

ATOM 3755 NZ LYS A 489 -21.376-12.998-36.223 1.0029.58 A

ATOM 3756 C LYS A 489 -18.283-12.863-31.8841.0024.65 A ATOM 3757 O LYS A 489 -17.617-13.650-31.2121.0026.03 A

ATOM 3258 N PHE. A 490 -1£611 -12.820-31.844 LOO 24.58 A

ATOM 3759 CA PHE A 490 -20369 -13.515-30.8J1 LOO 25.61 A

ATOM 3760- GB PHE A 490- -21.852-13.573-31.181 1.0027.25 A

ATOM -3761 CG-PHEA490 -22.635 -14.582 -3θi391 -1.0028.53 A- ATOM 3762-CDl-pHE A 490 -23.478- -14.179 -29.3691.0030.18 A

ATOM 3763 CD2 PHE A 490 -22.529-- L5.934 -30.671 1.00-29.3,4- A-

ATOM 3-764 CEl P-HE-A 490 -2^"4.199-15.105--28.640- 1.0030.55 A

ATOM 3765 CE2-PHEA490 -23.248-16.865-29.945 1.0030.42 A

ATOM- 3766 CZ PHE A 490 -24.Q&4 -16.450 -28.929 1.0030.66 A ATOM 3767 C PHE A 490 -19.830-14.923-30.585 1.0025.71 A

ATOM 3768 O PHE A 490 -19.988-15.493-29.506 1.0025.98 A

ATOM 3769 N HIS A 491 -19.193-15.479-31.611 1.0024.96 A

ATOM 3770 CA HIS A 491 -18.968-16.918-31.6841.0023.99 A

ATOM 3771 CB HIS A 491 -18.982-17.389-33.140 1.0022.63 A _m

ATOM 3772 CG HIS A 491 -20.354-17.486-33.7301.0021.04 A

ATOM 3773 CD2HISA491 -21.115-18.560-34.0481.0019.80 A

ATOM 3774 NDl HIS A 491 -21.102 -16.376 -34.063 1.0021.25 A

ATOM 3775 CEl HIS A 491 -22.263-16.763-34.5601.0021.24 A ATOM 3776 NE2 HIS A 491 -22.296 -18:083 =34.5621.0020.25 A

ATOM 3777^' C HIS A 491 -17.652-17.305 -31.0T9- -1.0024.02^' A

ATOM 3778 O HIS A 491 -17.490-18.432-30.552 1.0023.05 A

ATOM 3779 N VAL A 492 -16.715-16.364-30.9801.0024.69 A

ATOM 3780 CA VAL A 492 -15.401 -16.6-14 -30.399 l.^'OO 26.87 A ATOM 3781 CB VAL A 492 -14.385 -15.533 -3OrSlT 1.0026.86 A

ATOM 3782 CGlVAL A 492 -13.092-15.691-30:0281.0026.46 A

ATOM- 3783 CG2 VAL A492 -14J21 -15.595 -32.308^" 1.0026.66 A

ATOM 3784 C VAL A 492 -15.474-16.676-28.8771.0026.44 A

ATOM 3785 O VAL A 492 -14.941 -17.597 ,28.2571.0026.17 A ATOM 3786 N PROA 493 -16.135-15.689-28.2801.0026.3-1^" A

ATOM 3787 CD PRO A 493 -16.801 -14.560-28.952 b0027.58 A

ATOM 3788 CA PRO A 493 -16.299-15.641-26.823 1.0025.01 A

ATOM 3789 CB PROA 493 -17.017 -14.308 -26.598 1.0025.15 A

ATOM 3790 CG PRO A 493 -17.711-14.032-27.8841.0027.46 A ATOM 3791 C PRO A 493 -17.156-16.793-26.3081.0024.42 A

ATOM 3792 O PRO A 493 -16v843_-l 1376 -25.27-0170026,77 A

ATOM 3793 N ASN A 494 -18.225-17.112-27.030 1.00^22:16- A

ATOM- 379-4 CA ASK A-494- -19.068-18_^251 -26.6871.0019.71 -A-

ATΘM 3795 CTTASN A 494 -20,521 -17:982-27.085 1.0020.25 A ATOM 3796 GG ASN A 494 -21.081 -16.732 -26.435 1.00-23τ29 A

A-TΘM 3-797 ODl ASN A-494 -22.1 IS=- 16773 -25.773 1.0023τll A

ATOM 3798 ND2 ASN-A 494^' -20.394 -15.610-=26.621 1.0025.-63- A

ATOM 3799 C ASNA 494 -18.558-19.608-27.1621.0019.10 A

ATOM 3800 O ASN A 494 -19:262-20.613-27.070 1.0019.48- A ATOM 3801 N VAL A 495 -17.330-19:628-27.671 1.0018.74 A

ATOM 3802 CA VAL A 495 -16.649-20.880-27.9801.0020.82 A

ATOM 3803 CB VAL A 495 -16.149 -2L700 -26.7771.0019.25 A

ATOM 3804 CGl VAL A 495 -15.452-22.967-27.2491.0018.51 A

ATOM 3805 CG2 VAL A 495 -15.220-20.863-25.9121.0020.91 A ATOM 3806 C VAL A 495 -17.618-21.730-28.7961.0022.29 A

ATOM 3807 O VAL A 495 -17.981-22.835-28.3921.0022.24 A

ATOM 3808 N THR A 496 -18.032-21.208-29.945 1.0023.90 A

ATOM 3809 CA THR A 496 -18.743.-22.005-30.9381.0023.18 A ATOM 3810 CB THRA 496 -20.075--21.331 -31.3171.0024.15 A

ATOM 3811 OGl THR A 496 -21.134-21.877-30.5221.0026.53 A

ATOM 3812 CG2 THR A 496 -20.475-21.703-32.7371.0023.43 A

ATOM 3813 C THRA496 -17.890-22.218-32.1841.0022.37 A

ATOM 38140 THR A 496 -17.222-21.298-32.6551.0023.18 A ATOM 3815 ^ PRO A 497 -17.918-23.437-32.7141.0022.39 A

ATOM 3316 CDL PRO A 497 -18.371-24.638-31.9971.0021.71 A

ATOM 3817 CA PRO A 497 -17.110 -23.783 -33,8891.0023.13 A

ATOM 3818 CB PRO A 497 -17.262-25.305-33.9841.0022.70 A

ATOM 3819 CG PRO A 497 -17.481-25.729-32.5721.0022.08 A- ATOM 3820 C PRO A 497 -17.741-23,054-35.074 1.0023.19 A

ATOM 3821 O PRO A 497 -18.955-22.894-35.105 1.0023.31 A

ATOM 3822 N TYR A 498 -16.941 -22.609-36.039 LOO 22.79 A

ATOM 3823 CA TYR A 498 -17.506-21-864-37.155 1.0023.66 A

ATOM 3824 CB TYR A 498 -16.814-20.502-37.235 1.0022.49 A ATOM 3825 CG TYR A-498 -17.681-19.348-37.676 1.0021.14 A

ATOM 3826 CDl TYR A 498^" -18.539-18.712-36.783 1.0020.22- A

ATOM 3827 CEl TYRA 498 -19.347-17.632 -37J&61.0019.34^" A

ATOM 3828 CB2 TYR A 498 -17.642 -18,884 ^38τ9S61.0021.48 A-

ATOM 3829 CE2 TYRA 49& -18,447-17^36-39.3971.0020.72 A_ AϊOM-_3.830 CZ rm-A-498- -19.292-17.192-38.4891.00.19.76 A

A^TOM 3Ε31 OH TYR AΛ-9Εr -20.087 -14.149 -3S.&771.0020.01 A

ATOM 3832 C TYR A 498 -17.461 -22.5P9 -38τ5451^025.08- A^"

ATOM 38330 TYR A 498 -18.334-22.253-39.373 1.0024.30 A

ATOM 3834 N BLE A 499 -16.464 -23.365 -38.806 LθJ026r86 A ATOM 3835 CA ILE A 499 -1-6.315 -23.993 -4O.1261.0029.19 A

ATOM 3836 CB DLE A 499 -15.169-25.036-40.1701.0029.41 A

ATOM 3837 CG2 ILE A 499 -15.588-26.326-39.4401.0030.85 A

ATOM 3838 CGl ILE A 499 -14.870 -25.416 -41.6221.0030.64 A

ATOM 3839 CDl DLE A 499 -14.597-24.244-42.521 1.0028.01 A _m

ATOM 3840 C ILE A 499 -17.555-24.707-40.592 1.0030.83 A

ATOM 3841 O ILE A 499 -17.586-25.287-41.6641.0032.32 A

ATOM 3842 N ARG A 500 -18.586-24.683-39.7821.0032.52 A

ATOM 3843 CA ARG A 500 -19.799 -25.372 -40.157 IJIO 34.72 A ATOM 3844 CB ARG A 500 -20.424-25.897-38.911 1.0035.11 A

ATOM 3845 CG ARG A 500 -20.173-24.898-37.845 1.0035.19 A

ATOM 3846 CD ARG A 500 -21.271-24.856-36.878 1.0035.36 A

ATOM 3847 NE ARGA 500 -20.946-25.810-35.836 1.0033.87 A

ATOM 3848 CZ ARGA 500 -21.564 -25.91Q -34.6741.0032.30 A ATOM 3849 NHl ARG A 500 -22.577-25.106-34.3781.0029.21 A

ATOM 3850 NH2 ARG A 500 -21.133 -26,817 -33.810 hθO 32.33 A

ATOM 3851 C AROA 500 -20.766 -24.464 -"40.880 1.0035.89 A

ATOM 3852 O ARG A 500 -21.722-24.923-41.502 1.0037.39 A

ATOM 3853 N TYRA 501 -20.521-23,167-40,803 1.0037.26 A ATOM 3854 CA TYRA 501 -21.392 -22.235 -41.4851.0038J6 A

ATOM 3855 CB TYRA 501 -21.313-20.858-40.8421.0041.31 A

ATOM 3856 CG TYR A.501 -21.949 -20,827 -39.4S61.0044.79 A

ATOM 3857 CDl TYR A 501 -21.184-20.623-38.339 1.0046.66 A

ATOM 3858 CEl TYR A 501 -21.774-20.619-37.0701.0047.91 A ATOM 3859 CD2 TYRA 501 -23.319-21.026-39.3441.0046.41 A

ATOM 3860 CE2 TYRA 501 -23.920 -21.026 -38.089 LOO 48.76 A

ATOM 5-861 -CZ TYR A 501 -21.143-20.824-36.952 1.0048.54 A

ATOM 3862 OH TYR-A 5FL -21.729 -2&-S45 -35.7041.00r49.31 A

ATOM 3863-C TYRA 501 -2U;95-7 -22.190-42.928. JLDO 37.98- A ATOM 3864-O TYR=A 501 -2U-31 -21τ817-43.7981.0036.78 A-

ATOM 3865- N PHE A 502_ -197708-22.585 -43.t6S • fcθθ-37.42 A-

ATOM 3866 -CA PHEA 502 -15.158 -22.635--44.-522^" 1.00-36.94 A

ATOM 3867 CB- PHE A 502 -17.640 -22 JB31 -44.4781,0037.66 A

ATOM 3868 CG PHE A 502 -16.977-22.765-45.819 1.0039.28 A ATOM 3869 CDl PHE A 502 -16.823-21.547-46.4691.0040.33 A

ATOM 3870 CD2PHEA502 -16.496-23.920-46.428 1.0039.73 A

ATOM 3871 CEl PHE A 502 -16.200-21.475-47.7061.0041.55 A

ATOM 3872 CE2PHEA502 -15.872-23.860-47.664 1.0040.96 A

ATOM 3873 CZ PHE A 502 -15.724-22.634-48.305 1.0041.74 A ATOM 3874 C PHE A 502 -19.810-23.850-45.1791.0036.42 A

ATOM 3875 O PHE A 502 -20.512-23.736-46.1901.0036.55 A

ATOM 3876 N VAL A 503 -19.577-25.012-44.5701.0034.85 A

ATOM 38.77 CA VAL A 503 -20.132-26.271-45.035 1.0032.33 A ATOM 3878 CR VAL A 503 -19.995 -27.348 -43.9501.0029.74 A

ATOM 3879 CGl VAL A 503 -20.660-28.622 -44.39S 1.0029.51 A

ATOM 3880 CG2 VAL A 503 -18.537-27.600-43.6591.0027.23 A

ATOM 3881 C VAL A 503 -21.604-26.038-45.3221.0032.58 A

ATOM 3882 O VAL A 503 -22.134-26.420-46.3681.0033.01 A ATOM 3883 N SERA 504 -22.24^=25.378 -44.375 1.0031.73 A

ATOM 3884 CA SERA 504 -237659-25.058-44.473 1.0032.56 A

ATOM 3S85 CB SER A 504 -24.079-24.268-43.2261.0031.67 A

ATOM 3886 OG SERA 504 -25.423-23.822-43.293 1.0030.27 A

ATOM 3887 C SER A 504 -24.000 -24.261 -45.729 IJM) 33.41 A ATOM 3888 O SERA 504 -24.880-24.640-46.489 LOO 34.44 A

ATOM 3889 N PHE A 505 -23.307-23.153-45.948 1.0034.05 A

ATOM 3^890 CA PHE A 505 -23.604-22.326-47.1001.0034.45 A

ATOM 3891 CB- PHE A 505 -22.811-21.020-47.0001.0036.29 A

ATOM 3892 CG PHE A 505 -23.525-19.944-46.2261.0037.94 A ATOM 3893 CDl PHE A 505 -24.022-20.202 -44τ954 1.0039.15 A

ATOM 3894 CD2 PHE A 505 -23.724 -18.676 -46.780^" 1.0038.25 A

ATOM 3895 CEI PHE A 505 -24.709-19.219-44.244 1.0039.84 A

ATOM 3896 CE2 PHE A 505 -24.410 -17.6M-46τ0821.0038,56 A

ATOM 3897 GZL PHR A 505 -24.905-17.956-44:811 1.0040:4-2 A ATOM : ^"3898 C PHE A505 -23.364 -23JD35 -48v4421.0034.331 A

ATOM 3S99 O- THE A 505 -24.009 -22.741: -49.450 LOO 32750 A

ATOM- 3900 N VAL A 506^" -22.454-23.991-48.4641.0033,54 A

ATOM 3901 CA VAL A 506 -22.208-24,677-49.715 1.0032.67 A

ATOM 3902 CB VAL A 506 -20.788-25.281-49.7591.0032.02 A ATOM 3903 CGl VAL A 506 -20.721-26.446-50.7291.0031.02 A

ATOM 3904 CG2VALA506 -19.804-24.206-50.184 1.0032.13 A

ATOM 3905 C VAL A 506 -23.228 -25.771 -49.9081.0032.60 A

ATOM 3906 O VAL A 506 -23.741-25.994-50.985 1.0035.16 A

ATOM 3907 N LEU A 507 -23.571-26.430-48.833 1.0031.39 A _m

ATOM 3908 CA LEU A 507 -24.478-27.532-48.941 1.0030.41 A

ATOM 3909 CB LEUA 507 -23.931-28.583-48.035 1.0030.39 A

ATOM 3910 CG LEUA 507 -24.924-29.544-47.446 1.0029.97 A

ATOM 3911 CDl LEU A 507 -24.339-30.834-47.800 1.0030.43 A ATOM 3912 CD2LEUA507 -25.152-29.396-45.943 1.0029.81 A

ATOM 3913 C LEU A 507 -25.951-27.263-48.6641.0029.76 A

ATOM 3914 O LEU A 507 -26.759-28.169-48.424 1.0029.00 A

ATOM 3915 N GLN A 508 -26.308-25.998-48.693 1.0029.63 A

ATOM 3916 CA GLN A 508 -27.683-25.676-48:453 1.ΘO 30.50 A ATOM 3917 CB GLNA 508 -27.815-24.319-47.765 1.0030.36 A

ATOM 3918 CG GLN A 508 -27.634-23.114-48.629 1.0031.36 A

ATOM 3919 CD GLNA 508 -27.609 -21.838 -47.798 LOO 32.04- A

ATOM 3920 OEl GLN A 508 -28.122-20.796-48.215 1.0031.47 A

ATOM 3921 NE2 GLN A 508 -26.999-21.915-46.613 1.0031.67 A ATOM 3922 C GLN A 508 -28.322-25.687-49.815 1.0031.39 A

ATOM 3923 O GLNA-508 -29.507-25.931-49.9461.0032.15 A

ATQM 3924 N PHE A 509 -27.507 -25.460 -5Q.841 1.0032.41 A

ATOM 3925 CA PHE A 509 -27.989-25.474-52.214 1.0031.48 A

ATOM 3926 CB PHE A 509 -27.099-24.601-53.098 1.0031.31 A ATOM 3927 CG PHE A 509 -27.137-23.138-52.741 1.0030.78 A

ATOM 3928. CDl PHE A 509 -26.259 -22.613 -51.806 lTOO 31.68 A

ATOM 3929 CD2 PHE A-5.09 -28.041 -22.2S4 -53.346 IJOO 30.24 A

ATOM 3930 CEl PHE A 509 -26.282 -21.253- -51.4871.00^1.41 A

ATΘM 393-1 CE2PHEA5Θ9 -28.068 -20.921r53:028- 1.0030.91 A ATOM 3932 CZ PHE A 509 -277Ϊ8S--20.411 -52.101 1.0030.49 A^

ATOM -3933 C THEA 5C9 -Z8τ060 -26.900 -52J76& 1.Θ030.56 A

ATOM 3934 O- PHE A 509 -28.896- -27.191 -53,6081,0029.89 A

ATOM 3935 N GLNA 510 -27.185-27.788-52.3101.0030.11 A

ATOM 3936 CA GLNA 510 -27.236-29.162-52-778 1.0031.18 A ATOM 3937 CB GLNA 510 -26.193-30.039-52.087 1.0028.68 A

ATOM 3938 CG GLN A 510 -24.748-29.671-52.341 1.0026.11 A

ATOM 3939 CD GLN A 510 -23.833-30.875-52.200 1.0025.95 A

ATOM 3940 OEl GLN A 510 -22.645-30.749-51.8921.0025.64 A

ATOM 3941 NE2 GLNA 510 -24.386-32.054-52.437 1.0025.81 A _49?

ATOM 3942 C GLN A 510 -28.617-29.651-52.3791.0033.71 A

ATOM 3943 O GLNA 510 -29.274-30.379-53.1251.0035.79 A

ATOM 3944 N PHEA 511 -29.041-29.235-51.1891.0034.52 A

ATOM 3945 CA PHDE A 511 -30.343-29.601-50:643 1.0035.97 A ATOM 3946 CB PHEA 511 -30.490-29.111-49.1851.0036.44 A

ATOM 3947 CG THE A 511 -29.781-29.955-48.1471.0035.00 A

ATOM 3948 CDl PHE A 511 -28.791-30.875-48.4971.0034.68 A

ATOM 3949 CD2PHEA511 -30.084-29.777-46.7981.0035.08 A

ATOM- 3950 CEl PHE A 511 -28.106-31.606-47.513 1,0035.05 A ATOM^" 3951 CE2PHEA511 -29.413 -30.496 -45.SΘ41.0035.30 A

ATOM^" 3952 CZ EHEA 511 -28.418-31.415-46.164 1.0035.38 A

ATOM 3953 -C PHE AStI -31.430-28.935-51.4761.0035.93 A

ATOM 39540 PHEA511 -32.412-29.558-51.8591.0036.26 A

ATOM 3955 N HIS A 512 -31.251-27.651-51.7401.003-7.55 A - ATOM 3:956 CA HIS A 512 -32.232 -26.890 -52,5031.0039.62^~ A

ATOM 3957 CB HIS A 512 -31.765 -25.447 -5Z6641,0038.72 A

ATOM 3958 CG HIS A 512 -32.786 -24.550 -53.2S41.0037.10 A

ATOM 3959 CD2 HIS A 512 -32.665 -.23.565 -54.2041.0038.22 A

ATOM 3960 NDl HIS A 512 -34.113-24.565-52.9151.0036.55 A ATOM 3961 CEl HIS A 512 -34.766.-23.625-53.5.781.0037.21 A

ATOM 3962 NE2 HIS A 512 -33.910-23.003 -54.3671.0038.0-1 A

ATOM 3963 C ΗISA-512 -3J.473 -27.50T -53-.871 1.0041.19 A

ATOM 3964-O fflSA-512 -33.597-27.451 -543m 1.0041.38 A

ATOM 3965 N GLUA 513 -31.411. -28.031- -54.471 LOQ 42.46 A- ^" ATOM 3966 CA-GLU A 5D -3T.530 -28.649 -55.7841.004X83 A

ATOM 3967 CB-GLΕTA 513 -30. B3 -28:931 -56.3701.00^" 42τ45 A

ATOM.3968 CG GLU A 513 -30;I29 -29.340 -57.8421.0040.87 A

ATOM 3969 CD GLU-A 513 -28.734-29.653-58.3641.0039.37 A

ATOM 3970 OEl-GLU A 513 -28.029-30.479-57.7601.0038.92 A ATOM 3971 OE2 GLUA 513 -28.332-29.078-59.3871.0038.87 A

ATOM 3972 C GLUA 513 -32.303-29.948-55.5701.0043.12 A

ATOM 39730 GLUA 513 -33.419-30.121-56.0641.0043.31 A

ATOM 3974 N ALAA 514 -31.708-30.844-54.795 1.0042.92 A

ATOM 3975 CA ALA A 514 -32.311-32.131-54.4931.0042.91 A ATOM 3976 CB ALAA 514 -31.522-32.816-53.368 1.0044.02 A

ATOM 3977 C ALAA 514 -33.792-32.048-54.1161.0042.77 A

ATOM 3978 O ALA A 514 -34.590-32.885-54.520 1.0042.07 A

ATOM 3979 N ALA A 515 -34.170-31.046-53.340-1.0043.86 A ATOM 3980 CA ALA- A-515 -35.564 -30.931 -52.9321.0045.49 A

ATOM^" 3981 CB- ALA A 515 -35.701 -29.975^"-11.72I 1.0044.71 A

ATOM 3982 C ALA A 515 -36.430-30.453-54.0841.0045.81 A

ATOM 3983 O ALAA 515 -37.526-30.977-54.308 1.0045.73 A

ATOM 3984 N CYSA.516- -35.942-29:458-54.818 1.0046.17 A ATOM 3985 CA CYS A 516. -36.704-28.934-55.9401.0046.57 A

ATOM 3986 C CYS-A 516 -36:960-30.019-56^701.0047.64 A

ATOM- _3.987^: O" CYSA 516 -37.984 -30.014 -57.651 1.0046.83 A

ATOM 3988 CB CYS A 516 -35.971-27.770-56.585 1.0045.37 A

ATOM 3989 SG CYS A 516 -35.898-26.334-55.490 1.0046.37 A ATOM 3990 N LYS A 517 -36.03T-3O.958~57.080 1.0049.08 A

ATOM 3991 CA LYS A 517 -36.209-32.031-58.0391.0051.38 A

ATOM 3992 CB LYS A 517 -34.933-32.876-58.165 1.0051.08 A

ATOM 3993 CG LYS A 517 -34.977-33.884-59.309 1.0051.09 A

ATOM 3994 CD LYS A 517 -33.683-34.663-59.4481.0050.74 A ATOM 3995 CE LYS A 517 -33.824-35.791-60.478 1.0051.61 A

ATOM 3996 NZ LYS-A 517 -34.045 -35τ3-14 -61.8S3 1.0051.57 -A

ATOM 3997 C LYS A 5-17 -37396 -32T905^~-57.6291.0052.76 A

ATOM 5998-0 LYSA-51-7 -J8^90 -33.159 -58.431- 1.0053.39 A

ATOM 3999 N GtU A 518^" -37.429-33.354-56.3821.00-54:51 A ATOM 4000 CA GLU A 51-8- -38,548 -34.185--55.9661.0055.83 A

ATOM 4001 CB-GLU A-518 -38.249-34.827-54.648 iτ0056.80 A

ATOM 4002^"CG GLU A518 -37.545 -36.111-54.8141.0058?89- A

ATOM 4001 CD GLUA 518 -38.489-37.262-54:621 1.0060.61 A

ATOM 4004 OEl GLU A 518 -38.068-38.241-53.966 1.0060.39 A ATOM 4005 OE2 GLUA 518 -39.643-37.174-55.115 1.0061.85 A

ATOM 4006 C GLU A 518 -39.857-33.451-55.8741.0056.17 A

ATOM 4007 O GLUA 518 -40.922-34.051-55.973 1.0056.72 A

ATOM 4008 N ALAA 519 -39.788-32.147-55.673 1.0056.21 A

ATOM 4009 CA ALA A 519 -41.016-31.391-55.6141.0057.01 A _m

ATOM 4010 CB ALA A 519 -40.733-29.954-55.2941.0056.75 A

ATOM 4011 C ALA A 519 -41.608-31.517-57.0071.0057.82 A

ATOM 4012 O ALAA519 -42.821-31.506-57.1791.0058.37 A

ATOM 4013 N GLYA520 -40.735-31.671-58.0001.0058.31 A ATOM 4014 CA GLY A 520 -41.198 -31.809 -59;371 1.0.059-.05 A

ATOM 4015 C GLY A 520 -41.157-30.467-60,073 LOO 59.06- A

ATOM 4016 O GLY A 520 -41.880-30.197-61.0371.0059.42 A

ATOM 4017 N TYRA 521 -40.285-29.616-59.5691.0058.92 A

ATOM 4018 CA TYRA 521 -40.116 -28.302 -60.118 1.0057.56 A ATOM 4019 CB TYRA 521 -39.481 -27.407 -59.078 1.0056.7Z A

ATOM 4020 CG TYR A 521 -39.461 -25.989 -59:510 l,OOi5i5.4O A-

ATOM 4021 CDl TYR A 521 -40.626 -25:232.-59.441 1.0054.76 A

ATOM 4022 CEl TYR A 521 -40.634 -23.911 -59.7941.0054.50 A

ATOM 4023 CD2TYRA521 -38.282-25.386-59.962 LOO 55.09 A ATOM 4024 CE2 TYRA 521 -38.270 -24.051- -60.333- 1-.0055.22 A

ATOM 4025 CZ TYR A 521 -39.453-23.320-60.241 1.0054.68 A

ATOM 4026 OH TYR A 521 -39.451-22.002-60.6101.0054.05 A

ATOM 4027 C TYRA 521 -39.179-28.345-61.2921.0057.18 A

ATOM 4028 O TYRA 521 -38.248-29.141-61.3281.0057.28 A ATOM 4029 N GLU A 522 -39.467-27.531-62.2841.0056.56 A

ATOM 4030 CA GLU A 522 -38.541 -27.4G1 -.63.371 1.0056.09 A

ATOM 4031 CB GLU A 522 -18.735-28.335-64.5271760-57.02 A

ATOM 4032- €G GLUA-522 -37:649-29385 -64τ445 1.0058.11 A

ATOM 4033- CD GLU A 522^" -38.180 -30.70J -64.8r4^~l.0059.28 A" ATGM-4034 OEl GLUA-522 -39.274 -3-0.671 -65399- 1^"0O 59.75 A

ATOM 4Θ35--OE2GLUA-522 -37.543 -3T.739 -64.5J81.0060.18 A

ATOM 4036 C GLU A 522 -3^714 -25.990 -63.756^" 1.0IL55-21 A

ATOM 4037 O GLU A 522 -39.763-J25.383 -63.685 1.0054.57 A

ATOM 4038 N GLYA 523 -37.577 --25.466 -64.0441.0054.66 A ATOM 4.039 CA GLY A 523 -37.501-24.104-64.3571.0053.58 A

ATOM 4040 C GLY A 523 -36.165-24.040-63.685 1.0052.61 A

ATOM 4041 O GLY A 523 -35.492-25.066-63.453 1.0052.61 A

ATOM 4042 N PRO A 524 -35.738-22.846-63.3821.0051.10 A

ATOM 4043 CD PRO A 524 -36.494-21.632-63.741 1.0050.37 A ATOM 4044 CA PRO A 524 -34.502 -22.455 -62.7341.0050.25 A

ATOM 4045 CB PRO A 524 -34.354-21.023-63.1761.0050.56 A

ATOM 4046 CG PRO A 524 -35.387-20.895-64.3481.0050.33 A

ATOM 4047 C PRO A 524 -34.247 -22J98 -6 L267 1.0050.16 A

5 ATOM 4048 O PRO A 524 -34.949-22.031-60.406 1.0050.27 A

ATOM 4049^" N LEU A 525 -33.153-23.265-60.9721.0048.82 A

ATOM 4050 CA LEU A 525 -32.849-23.504-59.581 1.0047.90 A

ATOM 4051 CB LEUA 525 -31.426-24.042-59.421 1.0047.05 A

ATOM 4O52 CG LEU A 525 -31.189 -24.574 -58.001 1.0045.49 A

10 ATOM 4053 CDl LEU A 525 -32.242-25.595-57.6101.0044.89 A

ATOM 4054 CD2LEUA525 -29.822 -25τ204 -57.953 1.0045.61 A

ATOM 4055 C LEU A 525 -33:077-22.322-58.653 1,0047.76. A

ATOM 4056 O LEU A 525 -33.591-22.535-57.563 1.0048.69 A

ATOM 4057 N HIS A- 526 -32 J85 -21.094 -59.087 1.0046.79 A

15 ATOM 4058 CA fflS A 526 -32.961-19.936-58.222 1.0045.59 A

ATOM 4059 CB HIS A 526 -31.947-18.861-58.5971.0045J0 A

ATOM 4060 CG HIS A 526 -32.295-18.096-59.836 1.0044.77 A

ATOM 4061 CD2 HIS A 526 -32.860-16.874-59.9901.0044.34 A

ATOM 4062 NDl HIS A 526 -32.053-18.571-61.1081.0043.66 A

20. ATOM 4063 CEl HIS A 526 -32.453 -17.671 -61.990 1.0044.60 A

ATOM 4O64 NE2 HIS A 526 -32.946-16.633-61.338 1.0043.72 A

ATOM 4065 C HISA 526 -34360 -19.342 -58.2TX 1.00-45.59 A

ATOM- 4066 O HISA526r -34.-578 -18,285^~-57,626 LOO 44.23 A-

ATOM- 4067 N GLN A 527 -35.30SL20.002 -S&863 £0046.24 A

25 ATOM- 4068-CA-_GLN A 527 -3oτό73- 19.495 -58.8701.0046.90 A

ATOM 4069= CB GLN A 527 -37.iθ&-49rl 02 -60.2-9-1 1.0047.85 A

ATOM 4070 CG GLN A 52T -36.43^~6 -17.828 -60,798170049.10 A

ATOM 4071 CD GLNA-527^" -37.011-17.349 -62.1141.0049.36 A

ATOM 407-2 OEl GLN A 527 -37.1&8 -18.139 -63.043 1.0049.47 A

30 ATOM 4073 NE2GLNA527 -37.296-16.050-62.206 1.0048.08 A

ATOM 4074 C GLN A 527 -37.578-20.567-58.3071.0045.85 A

ATOM 4075 O GLN A 527 -38.792-20.390-58.2071.0044.88 A

ATOM 4076 N CYS A 528 -36.960-21.677-57.920 1.0045.84 A

ATOM 4077 CA CYS A 528 -37.693-22.795-57.361 1.0046.87 A _m

ATOM 4078 C CYS A 528 -38.232-22.443-56.0021.0047.68 A

ATOM 4079 O CYS A 528 -37.652-21.647-55.2771.0048.41 A

ATOM 4080 CB CYS A 528 -36.813-24.033-57.2341.0046.41 A

ATOM 4081 SG CYS A 528 -37.487-25.184-56.001 1.0044.80 A ATOM 4082 N ASP A 529 -39.362 -23.047 -55.6501.0047.69 A

ATOM 4083 CA ASP A 529 -39.977 -^"22.824 -54.3471.0047.81 A

ATOM 4084 CB ASP A 529 -40.951-21.646-54.409 1.0045.58 A

ATOM 4085 CG ASP A 529 -41.866-21.582-53.2021.0045.30 A

ATOM 4086 ODl ASP A 529 -41.920-22.572-52.442 LOO 42.82 A ATOM 4087 OD2 ASP A 529 -42.567-20.585-52.9321.0045.27 A

ATOM 4088 C ASP A 529 -40.698-24.075-53.856 LOO 48.85 A

ATOM 4089 O ASP A 529 -41.803-24.383-54.303 1.0049.52 A

ATOM 4090 N ILE A 530 -40.066 -24.793 -52.933 1.0049.34 A

ATOM 4091 CA ILE A 530 -40.539-26.112-52.5301.005037 A ATOM -4092 CB ILE A 530 -39.408-26.906-51.8491.0050.65 A

ATOM 4093 CG2ILEA530 -39.679-27.047-50.3591.0050.70 A

ATOM 4094 CGl ILE A 530 -39.25_1 -28.279-52.5041.0051.03 A

ATOM 4095 CDl ILE A 530 -37.815-28.749-52.6021.005.0.05 A

ATΘM 4096 C BLE A 530 -41.743-26.007-51.600 1.0051.69 A ATOM 4097 O ELEA-530 -41.941-26.851-50.7261.0051.88 A

ATOM 4098 N- TYRA 531 -42.544-24.965-51.7981.0053.11 A

ATOM 4099 CA TYR-A 531 -43.689 -24.697 -50.9361.005^~4v83 A

ATOM 4100 CB-TYRA 531 -44τ362 -23.383 -51.3391.00.56.21 A

AIΘM 4101 CG TYR A- 531 -45.323-22.841-50.306-1.-0057.91 A ATOM 4102 CDl TYRAJBl -4-5.149 -23.116 -48.956-L00-59r23 A

ATOM 4103 -CEl TYR A 531- -46.025-22.622-48.0071.0060r&9 A

ATOM 4104 CD2 TYRA 531 -46.403 -22.053 -50,680 OO 58J9T A-

ATOM 4105 CE2-TYRA531 -47.284-21.555-49.7391.0060.57 A

ATOM 4106 CZ TYRA 531 -47.090-21.842-48.4051.0061.35 A ATOM 4107 OH TYRA 531 -47.965-21.349-47.463 1.0062.27 A

ATOM 4108 C TYRA 531 -44.777-25.757-51.0631.0055.39 A

ATOM 4109 O TYRA 531 -44.991-26.315-52.1391.0056.36 A

ATOM 4110 N ARGA 532 -45.463-26.029-49.9571.0054.87 A

ATOM 4111 CA ARG A 532 -46.706-26.790-49.994 1.0052.89 A ATOM 4112 CB ARGA 532 -47.833-26.086-50.7521.0051.63 A

ATOM 4113 CG ARGA 532 -48.589-25.059-49.925 1.0052.41 A

ATOM 4114 CD ARGA 532 -50.031-24.850-50.3621.0053.94 A

ATOM 4115 NE ARG A 532 -50.725-23.887-49.512 1.0057.07 A ATOM 4116 CZ ARG A 532 -51.287-24.189-48.3501.0059.29 A

ATOM 4117 NHl ARG A 532 -51.240 -25.432 -47.891 1.0060.O8 A

ATOM 4118 NH2 ARG A 532 -51.898-23.248-47.643 1.0060.79 A

ATOM 4119 C ARG A 532 -46.402-28.138-50.6401.0052.54 A

ATOM 4120 O ARGA 532 -47.308 -2O44 -51.0821.0053.93 A ATOM 4121 N SERA 533 -45.120-28.487-50.6921.0051.49 A

ATOM 4-122 CA SERA 533 -44.674-29.651-51.448 1.0051.67 A

ATOM 4123 CB SERA 533 -43.401-29.325-52.2321.0052.51 A

ATOM 4124 OG SERA 533 -42.847-30.493-52.813 1.0052.05 A

ATOM 4125 C SERA 533 -44.433-30.844-50.5301.0051.87 A ATOM 41260 SERA 533 -43.319-31.056-50.051 LQO 51.70 A

ATOM 4127 N THRA 534 -45.484-31.621-50.2891.-0052.21 A

ATOM 4128 CA THR A 534 -45.424-32.715 -49.3261.0053.0D A

ATOM 4129 CB THRA 534 -46.810-33.388-49.191 1.0053.62 A

ATOM 4130 OGl THR A 534 -47.120-34.125-50.3821.0053.90 A ATOM 4131 CG2THRA534 -47.881-32.319-48,973 1.0054.06 A

ATOM 4132 C THR A 534 -44.422-33:762-49.771 1.0052.72 A

ATOM 4133 O THRA 534 ^"43.878-34539-48:983 1.0052.88 A

ATOM 4134 N LYS A 535 -44.206-33.768-51.072 L0053.47- A

ATOM 4135 CA LYS A 535 -43:3-10^'-34.72I -51.7121.0053.94 A ATOM 4136 CB EYS A 535 -43.642-34.734-53.2171.0052.54 A

ATOM 4137 CGJrYS A 535 -45.157-34.540-53.4901:0049.85 A

ATOM 4138 CD LYS A 535 -45.534-33:057-53.67-1 1.0049.61 A

ATOM 4139 CE LYS A 535 -47.051-32.853,-53.8791.0049.59 A

ATOM 4140 NZ LYS A 535 -47.446-31.399-53.873 1.0047.92 A ATOM 4141 C LYS A 535 -41.824-34.407-51.4341.0054.72 A

ATOM 4142 O LYS A 535 -41.002-35.316-51.1861.0053.97 A

ATOM 4143 N ALAA536 -41.513-33.110-51.453 1.0055.33 A

ATOM 4144 CA ALA A 536 -40.178-32.607-51.1961.0055.43 A

ATOM 4145 CB ALAA 536 -40.111-31.139-51.5971.0055.29 A _5Q3

ATOM 4146 C ALA A 536 -39.897-32.769-49.7021.0055.64 A

ATOM 41470 ALA A 536 -38.897-33.374-49.305 1.0055.54 A

ATOM 4148 N GLY A 537 -40.804-32.241-48.883 1.0055.22 A

ATOM 4149 CA GLY A 537 -40.644-32.313-47.442 1.0055.04 A ATOM 4150 C GLY A 537 -40.358 -337692 -46.865 LOO 54.59 A

ATOM 4151 O GLY A 537 -39.616-33.831-45.891 1.0055.19 A

ATOM 4152 N ALA A 538 -40.936-34.723-47.4641.0053.06 A

ATOM 4153 CA ALA A 538 -40.749-36.076-46.966 1.0051.94 A

ATOM 41-54 CB ALA A 538 -41.680-37.020-47.6861.0052.39 A ATOM 4155 C ALA A 538 -39321 -36.524-47.168 LOO 51.76 A

ATOM^"" 4156 -O ALA A 538 -38-.8Θ7 -37.390 -46.4521.0052.18 A

ATOM 4.1-57 N LYS A 539 -38_^693 -35.927 -48.171 1.0051.16 A

ATOM 4158 CA LYS A 539 -37.322-36.254-48.5301.0050.24 A

ATOM 4159 CB LYS A 539 -37.035 -35J675 -49.8941.00-49.01 A ATOM 4160 GG LYS A 539 -35:923-36.336-50.583 1. OQ 47.0-1 A

ATOM 4161 CD LYS A 539 -3i.339-35.3i56 -51.5541.0044.85 A

ATOM 4162 CE LYS A 539 -34.181-36.0-19-52.2271.0043.62 A

ATOM 4163 NZ LYS A 539 -34.470-37.488-52.234 1.0043.89 A

ATOM 4164 C LYS A 539 -36.353-35.667-47.526 1.0049.85 A ATOM 4165 O LYS_A 539 -35.321-36.259-47.17-71.0048,81 A

ATOM 4166 N LEU.A_540 -36.728-34.480-47.068 1.0049.97 A

ATOM- 4167 CA LEUA 540 -35.942-33.730-46.108 1,00:50.22 A.

ATOM- -4168 CB LEU A 540 -36=478 -32.307 -45.9871.0048.81 A

ATOM 4169 CG-JLEU-A 540 -35.551 -31192 -45.496 Lfl.G47:47 A ATOM, 4170 CD!^' LEU A 540 -36.411 -30.156 -44.782 IJQHB 46.64 A

ATOM- 4171 CD2 LEU A 54O -34.4-71 -317729--44.575- LOO 45.77 A

ATOM 4172 C LEU A 540 -36.047 -34.388--44-.756 k005.0:71 A

ATOM- 4173 O LEU A 540 -35.044-34,629-44.0771.0050.73 A

ATOM 4174 N ARG A 541 -37.276-34.687-44.363 1.005031 A ATOM 4175 CA ARG A 541 -37.452-35.287-43.059 1.0050.18 A

ATOM 4176 CB ARG A 541 -38.914-35.476-42.7291.0051.35 A

ATOM 4177 CG ARG A 541 -39.140-36.891-42.2361.0054.03 A

ATOM 4178 CD ARG A 541 -40.456-37.077-41.572 1.0056.25 A

ATOM 4179 NE ARG A 541 -41.491-36.241-42.1671.0058.07 A _5Q4

ATOM 4180 CZ ARG A 541 -42.280-36.597-43.1761.0059.08 A

ATOM 4181 NHl ARG A 541 -42.157-37.798-43.729 1.0059.25 A

ATOM 4182 NH2 ARG A 541 -43.216-35.752-43.611 1.0059.38 A

ATOM 4183 C ARG A 541 -36.738-36.619-42.853 1.0049:07 A ATOM- 4184 O ARG A 541 -36.461-37.006-41.721 1.0049.10 A

ATOM 4185 N ALA A 542 -36:450-37.332-43.931 1.0048.76 A

ATOM 4186 CA ALA A 542 -35.779-38.611-43.783 1.0049.31 A

ATOM 4187 CB ALAA 542 -35.742-39.351-45.1041.0049.01 A

ATOM 4T88-C ALAA542 -34.376-38.329-43.291 1.Θ049.48 A ATOM 4189 O ALA A 542 -33.824-39.082-42.503 1.0049.91 A

ATOM 4190 N ^"VALA 543 -337805-37.216-43.735 1.0049.49 A

ATOM.4191 CA VALA 543 -32.452 -36.852 -43.3 H 1.0049.12 A

ATOM 4192 CB VAL A 543 -31.853-35.726-44.2221.0049.18 A

ATOM 4-193 CGl-VAL A.543 -32.550-35.730-45.5641.0049.82 A- ATOM 4194 CG2 VAX A 543 -31.995-34.351-43.575 1.0048:93 A

ATOM 4195 C VAL A 543 -32.499-36.379-41.8551.0048.79 A

ATOM 4196 O VAL A 543 -31.623-36.704-41.042 1.00-47.71 A

ATOM 4197 N LEU A 544 -33.542-35.613 -41.541 1.0047.69 A

ATOM 4198 CA LEU A 544 -33.725-35.104-40.195 1.0046.33 A ATOM 4199 CB LEU A 544 -35.003 -34.263 -4Q.1161.0044.01 A

ATOM 4200 €G LEU A 544 -34.943 -32.988 -4Q.945 1.0042.97 A

ATOM 42Ol -CBl-LEUA 544 -36.140 -32.103 -40.6641.Θ042J0 A

ATOM 4202 CB2 LEU A 544 -33.665 -32.259 -40.596- 1.0043V72 A

ATΘM 42GtTC LEU A 544 -33.804-36.2-73-39^2141.0046.46 A ATOM--4204-O LEU A 544 -33..00Θ -36.401 -38.283 1.0046.51 A

ATOM^" 4205 N ALA A 545 -347771 -37rl47 -39.4461.O045.16 A

ATOM 4206 CAALA A 545 -34.970 -3^;8r290^38^'.581 1.0043.31 A

ATOM 4207-CB ALA A 545 -36-160 -39.095 -39.068 1.0044J79 A-

ATOM 4208 C ALA A 545 -33.758-39.206-38.441 1.0041.75 A ATOM^" 4209 O ALA A 545 -33.846 -4Q.257 -37.8161.0041.40 A

ATOM 4210 N ALA A 546 -32.614-38.824-38.9951.0040.31 A

ATOM 4211 CA ALA A 546 -31.448-39.700-38.8871.0040.04 A

ATOM 4212 CB ALA A 546 -30.730-39.794-40.232 1.0039.67 A

ATOM 4213 C ALA A 546 -30.456-39.304-37.805 1.0039.82 A _5Q5

ATOM 42140 ALA A 546 -29.693-40.149-37.3141.0038.20 A

ATOM 4215 N GLY A 547 -30.470-38.023-37.441 1.0039.71 A

ATOM 4216 CA GLY A 547 -29.559-37.536-36.4221.0041.46 A

ATOM 4217 C GLY A 547 -28.116-37.916-36.7101.0042.94 A

5 ATOM^" 4218 O GLY A 547 -27τ620 -37,682-37.805 1.00^" 43.39 A

ATOM 4219 N ALA A 545- -27.434-38.507-35.735 1.0044:03 A

ATOM 4220 CA ALA A 548 -26.041-38.907-35.921 1.0043.50 A

ATOM 4221 CB ALA A 548 -25.189-38.398-34.749 1.0044.89 A

ATOM 4222 C ALA A 548 -25.93^"9-40.41-6-36.02O 1.00-43.52 A 0 ATOM 4223 O ALA A 548 -24.849-40.985-35.9061.0044.62 A

ATOM 4224 N SERrA 549 -27.084 -41.O60--36.238 LSO 45790 A

ATOM.4225 CA SER A 549 -27.141 -42.523-363241.0047.05- A

ATOM 4226 CB SER A 549 -28.593-42.994-36.441 1.0047.67 A

ATOM 4227 OG SER A 549 -29.0ΘΘ -43.042-37.7971.0052.22 A 5 ATOM 4228 C SER A 549 -26.323-43.087-3714901.0046.55- A

ATOM 4229 O SER A 549 -25.535 -44.019-37.3241.0044.72 A

ATOM 4230 N ARGA 550 -26.702-42.714-38,740 1.0047.15 A

ATOM 4231 CA ARGA 550 -25.939-42.840-40.063 1.0045.33 A

ATOM 4232 CB ARGA 550 -25.556 -44.271 -40.336 LOO 45.80 A Q ATOM 4233 CG ARG A 550 -26.671-45.276-41.038 1.0044.79 A

ATOM 4234 CD ARGA 55$ -26.S67 -45332 -427551- 1.0045.75 A

ATOM 4235 NE ARG A 550 -28.0T9 -44.588 -43.025 1700- 47.90 A

ATOM 4236 CZ. ARGA- 550 -2SΛSQ -44JL49 -44.2651.0045:05 A ATOM 4237^~NH1 ARG A.55Θ- -27.284-44.432 -45.151 1.00-50.16 A 5- ATOM 4238 NH2 ARG A-550 -297224-=43.426 -44.602 ϊτ00;50.-14 A

ATOM -4239 C ARG A 550 -24,897-41.805-40.4521.00-44704 A

ATOM- 4240-O ARG A^" 550 -25.158-4(1669-. -40.2301.00-43.16 A

ATOM 4241 N PROA 551 -23.766 -42.188 -4T.051 1.0044.-59- A

ATOM 4242 CD PRO A 551 -23.394 -43.58J -41.3521.00-43.62 A 0 ATOM 4243 CA PRO A 551 -22.714-41.267-41.516 1.0045.07 A

ATOM 4244 CB PRO A 551 -21.749-42.189-42.253 1.0043.63 A

ATOM 4245 CG PRO A 551 -21.893-43.476-41.531 1.0043.47 A

ATOM 4246 C PRO A 551 -23.319-40.205-42.443 1.0047.24 A

ATOM 42470 PRO A 551 -24.118-40.535-43.3251.0047.46 A ..,

3Uo

ATOM 4248 N TRP A 552 -22.947-38.940-42.2651.0046.97 A

ATOM 4249 CA TRP A 552 -23.525-37.899-43.1061.0048.26 A

ATOM 4250 CB TRP A 552 -22.917-36.519-42.801 1.0050.27 A

ATOM 4251 CG TRP A 552 -21.414-36.333-43.0991.0052.19 A ATOM 4252 CD2 TRP A 552 -20.821 -35.885^~-44.3321.00-52r88 A

ATOM 4253 CE2TRPA552 -19.428-35.778-44.1151.0052.80 A

ATOM 4254 CE3 TRP A 552 -21.333-35.560-45.5961.0051.97 A

ATOM 4255 CDl TRP A 552 -20.376-36.483-42.219 1.0052.50 A

ATOM 4256 NEl TRP A 552 -19.185-36.147-42.8191.0052.27 A ATOM 4257 CZ2 TRP A 552 -18.545-35.360-45.113 1.0052.69 A

ATOM 4258 CZ3 TRP A 552 -20.455-35.148-46.5821.0051-.42 A

ATOM 4259 CH2 TRP A 552 -19:078 -35.051 -46.336 LGO 51.96 A

ATOM 4260 C TRP A 552 -23.290-38.224-44.5691.0047.96 A

ATOM 4261 O TRP A 552 -24.148-38.040-45.4401.0047.76 A ATOM 4262 N GLN A 553 -22.1Θ0 -38.715-44.841 1.0048.94 A

ATOM 4263 CA GLN A 553 -21.747-39.044-46.201 1.0049.76 A

ATOM 4264 CB GLN A 553 -20.347-39.551-46,195 LOO 48.62 A

ATOM 4265 CG GLN A 553 -19.756-39.246-44.8771.0049.62 A

ATOM 4266 CD GLN A 553 -18.315-38.947-44.9821.0050.98 A ATOM 4267 OEl GLN A 553 -17.921-38.039-45.7091.0051.63 A

ATOM 4268 NE2 GLN A 553 -17.494-39.708-44.261 LO0-5U1 A

ATOM 4269 C GLN A 553 -22.687 -40.043 -46.853 1.0050.24 A

ATOM 4270 O GLN A 553 -22.689 -40.L79 -48.0661.0051.45 A

ATOM 4271 N GLHA554 -2-3.490-40.733-46.048 L00-50.7B A AXQM 4272 CA-GLU A 554 -24.462 -4L691 -46.5641.0Q-49ϊ96 'A

ATOM 4273 CB GLU A 554 -24.5-38 -42.939--45.68T LOO 50,80 A

ATOM 4274 CG GLU A 554 -23.653-44.079-46.1261.0051:63 A

ATOM 4275 CD GLU A 554 -23.615 -45.204 -45 J 18 1.0052.89 A

ATOM 4276 OEl GLU A 554 -24.668-45.505-44-5041.0053.48 A ATOM 4277 OE2 GLU A 554 -22.529-45.796-44.9501.0052.99 A

ATOM 4278 C GLU A 554 -25.804-41.002-46.588 1.0049.13 A

ATOM 42790 GLUA 554 -26.503-41.048-47.5821.0049.56 A

ATOM 4280 N VAL A 555 -26.153-40.351-45.488 1.0047.92 A

ATOM 4281 CA VAL A 555 -27.427-39.648-45.411 1.0046.97 A ATOM 4282 CB VAL A 555 -27.585 -38.955 -44.055 1.0046.96 A

ATOM 4283 CGl VAL A 555 -29.036-38.514-43.845 1.0046.53 A

ATOM 4284 CG2 VAL A 555 -27.126-39.896-42.970 1.0047.70 A

ATOM 4285 C VAL A 555 -27.504-38.604-46.513 1.0046.26 A ATOM 4286 O VAL A 555 -28.591-38.218-46.9461.0045.46 A

ATOM 4287 N LEU A 556 -26.336-38.149-46.959 1.0046.50 A

ATOM 4288 CA LEU A 556 -26.259-37.157-48.030 1.0046.38 A

ATOM 4289 CB LEUA 556 -24.873-36.495-48.048 1.0044.73 A

ATOM 4290 CG LEU A 556 -24.664-35.375 -49.074^" 1.0041.94 A ATOM 4291 CDl LEU A 556 -25..770 -34.343 -48.958 1.0040.10 A

ATOM 4292 CD2 LEU A 556 -23.315.-34.731-48.8421.0041.42 A

ATOM 4293 C LEUA 556 -26.539 -37.837 -49.37S 1.0046.75 A

ATOM 4294 O LEU A 556 -27.383-37.374-50.155 1.0045.74 A

ATOM 4295 N LYS A 557 -25.840-38.943-49.639 1.0047.19 A ATOM 4296 CA LYS A 557 -26.028 -39_;685^~-50.878 1.0047.GS A

ATOM 4297 CB LYS A 557 -25.221-40.978-50^671.0046.46 A

ATOM 4298 CG LYS A 557 -25.111 -41.624 -"52.242 1.0046.98 A

ATOM 4299 CD LYS A 557 -23.986-42.653-52.270 1.0047.05 A

ATOM 4300- CE LYS A 557 --23.515 -42.899 -53.6841.0046.61 A ATOM 4301 NZ LYS A 557 -22.192-43.577-53.701 1.0047.09 A

ATOM 4302 C LYS^"A557 -27.504 -40.000 -51.0R81.0047.63 A

ATOM -4303 Θ LYS A 557 -28.054-39.674-52,1261,0048.6S A-

ATOM 4304 N ASP A 558 -2^152.-40.627-50.113 1:0047.84 A

ATOM 4305 CA- ASPA55T -29.573 -40.941 -5.GL2.40 1.00=48.06 A ATOM 430.6 CB-ASP A-558- -30.133M1.46-1- -48.9121.0050.06- A

-ATOM 4307 CG ASPA 558 -29.796 -42.919 -4&.6S91.0052.25 A

ATOM 4308 ODl ASP A 558. -28.59-9^43,279-48.723-1.00-52.85^" A

AIOM 4399- OD2 ASP A 558 -30735-43.703-48.386 1.0053.92 A

ATOM 4310 C ASP A 558 -30.3S7 -39714 -50,654 1.0047.36 A ATOM 4311 O ASP A 558 -31.253-39783-51.5191.0047.89 A

ATOM 4312 N META 559 -30.102-38.576-50.0441.0046.41 A

ATOM 4313 CA META 559 -30.864-37.377-50.350 1.0045.63 A

ATOM 4314 CB MET A 559 -30.836-36.425-49.158 1.0044.34 A

ATOM 4315 CG META 559 -31.548-35.122-49.431 1.0042.64 A ATOM 4316 SD MET A 559 -30.871-33.779-48.4761.0043.40 A

ATOM 4317 CE MET A 559 -32.271-32.650-48.382 1.0041.50 A

ATOM 4318 C MET A 559 -30.458-36.600-51.5941.0045.92 A

ATOM 4319 O MET A 559 -31.315-36.142-52.3391.0045.11 A ATOM 4320 N VAL A 560 -29.159-36.435-51.8171,0046.31 A

ATOM 4321 CA VAL A 560 -28.698-35.664-52.965 1.0046.52 A

ATOM 4322 CB VAL A 560 -27.708-34.578-52.496 1.0046.80 A

ATOM 4323 CGl VAL A 560 -27.090-33.863-53.6841.0048.49 A

ATOM 4324 CG2 VAL A-360 -28.443-33.575-51.6321.0047.09 A ATOM 4325 C VAL A 560 -28.079-36.473-54.110 1.0046.55 A

ATOM 4326 O VAL A 560 -28.072-36.033-55.2571.0046.12 A

ATOM 4327 N GLYAJ61 -27.568-37.655-53.8071.0046.79 A

ATOM 4328 CA GLYA 561 -26.977-38.470-54.848 1.0047.30 A

ATOM 4329 C GLY A 561 -25.473-38.338-54.850 1.0048.32 A ATOM 4330 Q GLYA 561 -24.785-38.914-55.701 1.0048.34 A

ATOM^" 4331 N LEUA 562 -24.951-37.587-53.883 1.0048.71 A

ATOM 4332 CA LEU A 562 -23.512-37382-53.8021.6048.13 A

ATOM 4333 CB LEUA 562 -23.176-35.916-54.103 1.0047.90 A

ATOM 4334 GG LEU A 562 -22.310^' -35.695 -55.3491.0047.26 A ATOM 4335 CDl-LEU A 562 -22.042-34.214-55.502 1.0046.90 A

ATOM 4336 CD2 LEU A 562 -20.992 -36.477 -55.232 L0046.65 A

ATOM 4337 C LEU A 562 -22354-37.804-52.489 LOO 46.55 A

ATOM 4338 O LEU A 562 -23.401 -37.624-51.405 LM 46.29 A

-ATOM 4339- .N ASP-A563 -21.658 -38,362 -52.6261:GB 44.96 A- ATOM^" 4340 CA ASP A 563

ϊτθ.0_43.59 A

ATOM 434-t CB ASP A 563 -19.714-39.680 -52.Ω3-1 1.0045.04 A

ATOM 4342 CG- ASP'A- 563 - 19.758 -41.088 -5 L510 LOO 47.48 A

ATOM 4343 ODl ASP A 563 -20.687-41.828-51.9041.0049.10 A

ATOM 4344 OD2 ASP A 563 -18.865-41,454-50-708 1.0048.25 A ATOM 4345 C ASP A 563 -20.264-37.682-50.726 1.0043.06 A

ATOM 43460 ASP A 563 -19.743-37.910-49.645 1.0043.68 A

ATOM 4347 N ALA A 564 -20.311-36.458-51.252 1.0041.75 A

ATOM 4348 CA ALA A 564 -19.715 -35.328 -50.5391.0039.92 A

ATOM 4349 CB ALA A 564 -18.208-35.376-50.695 1.0039.82 A 5 W

ATOM 4350 C ALA A 564 -20.213-33.935-50.903 1.0038.73 A

ATOM 4351 O ALA A 564 -21.185-33.783-51.638 1.0037.49 A

ATOM 4352 N LEU A 565 -19.531-32.922-50.358 1.0038.41 A

ATOM 4353 CA LEU A 565 -19.863-31.513-50.5941.0037.66 A ATOM 4354 CB LEUA 565 -19.051-30.598-49.680 1.0037.36 A

ATΘM 4355 CG LEσA 565 -19.589-30377-48.265 1.0038.19 A

ATOM 4356 CDl LEU A 565 -18.510-29.761-47.385 1.0038.85 A

ATOM 4357 CD2 LEU A 565 -20.819-29.478-48.3291.0038.01 A

ATOM 4358 C LEU A 565 -19.537-31.186-52.0271.0037.44 A ATOM 43590 LEU A 565 -18.520-31.645-52.551 1.0036.42 A

ATOM 4360 N ASP A 566 -20.392 -30.383 -.52.6521.-0037.21 A

ATOM 4361 CA ASFA 566 -20.216 -30.015 -54.0491.0037.23 A

ATOM 4362 CB ASP A 566 -21.028-30.980-54.922 1.0039.92 A

ATOM 4363 CG ASP A 566 -20.633-30.929-56.371 1.0041.52 A ATOM 4364 ODl ASP-A 566 -19.443-31181-56.675 1.0043,01 A

ATOM 4365 OD2 ASP A 566 -21.521-30.646-57.198 1.0043.00 A

ATOM 4366 C ASP A 566 -20.69-8-28.587-54.243 LOO 36.16 A

ATOM 43670 ASP A 566 -21.782-28.226-53.791 1.0034.09 A

ATOM 4368 N ALA A 567 -19.890-27.774-54.9121.0036.25 A ATOM.4369 CA ALA A 567 -20.250-26.378-55.135 1.0036.57 A

ATOM 4370 CB ALA A 567 -18.99S -25.529 -55.1741.0035.93 A

ATOM 437TC ALA-A 567 -21.020-26.232-56.4361.003639 A

ATOM 4372 O ALA A 567 -21.609 -25,186 -56.718 LOO 36.38 A.

ATOM 4373 N^" ALA-A368 -2JL0r9-.22.311 -57.2161.0036.93 A ATOM 4374 -CA ALA A 568 -21.684 -27.340. -58.5101.0036.61 A

ATΘM 4375 CB-ALA A 568 -21.719 -28.750 -.59.0261.0^36.29 A

ATΘM^" 4376 C ALA-A 568 -23.095 -26.7_65 -58:4441.0036:17 A

ATOM 43770 ALA A 568 -23.426-25.788-59.131 1JO.G 37.38 A

ATOM 4378 N PRO A 569 -23.945-27.340-57.580 1.0035.14 A ATOM 4379 CD PRO A 569 -23.704-28.420-56.6071.0034.86 A

ATOM 4380 CA PRO A 569 -25.316-26.836-57.478 1.0034.34 A

ATOM 4381 CB PRO A 569 -25.986-27.831-56.543 1.0034.52 A

ATOM 4382 CG PRO A 569 -24.859-28.256-55.6641.0036.33 A

ATOM 4383 C PRO A 569 -25.428-25.412-57.0041.0033.23 A ATOM 43840 PRO A 569 -26.487-24.795-57.105 1.0033.17 A

ATOM 4385 N LEU A 570 -24.326-24.895-56.488 1.0033.10 A

ATOM 4386 CA LEU A 570 -24.287-23.523-56.003 1.0033.65 A

ATOM 4387 CB LEUA 570 -23.2-16 -23.4JO4 -54.9101.003.4.37 A AT-OM 4388 CG LEUA 570. -22.603 -22.051 -54.509- 1.0034.76 A

AT©M 4389 CDl LEU A 570 -23.638-20.969-54.4261.0033.40 A

ATOM 4390 CD2LEUA570 -21.914-22.212-53.1671.0035.81 A

ATOM 4391 C LEUA 570 -23.988-22.583-57.1771.0033.47 A

ATQM 4392 O LEU A 570 -24:589-21.517-57.3241.0032.95 A ATOM 4393 N LEU A 571 -23.061-23,011-38.0221.0032.97 A

ATOM 4-354^" CA LEU A-571 -22.657 -22.246 -59.189- 1.0032.40 A

ATOM 4395: CB LEU A 571 -21.514 -22.983-59.869 1.0032.05 A

ATOM 4396 CG LEU A 571 -20.337-23.210-58.913 1.0032.23 A

ATOM 439-7 CDl LEU A 571 -19.233-24.028-59.5691.0032.18 A ATOM 4398 CD2LEUA571 -19.805 -21.858"-58.4771.0030.96 A

ATOM 4399 C LEU A 571 -23.846-22.103-60.1301.0032:95 A

ATOM 4400 O LEU A 571 -24.055 -21.088 -60.791 1.0032.29 A

ATOM 4401 N LYS A 572 -24.634-23.159-60.1391.0034.72 A

ATOM 4402 CA LYS A 572 -25.836. -23.290 -60.9461.0036.95 A ATOM 4403 CB LYS A 572 -26.193-24.756-60.9141.0038.54 A

ATOM 44=04- CG LYS A 572 -21.571-25.148-61.2471.0039.43 A

ATOM 4405 ^"CD LYS A 572 -2-7.470 -2βτ630 -6X208 1.0039:95 A

ATOM 4406 CEJtYS A 572 -28.437-27.293-62.126 1.0040.40 A

ATOM 4407 NZ LYS A 572 -28,040 -28.718 -62.-33:8.1.003.9.89 A_ ATOM 4408-e LYS A 5.72 -26.988-22.430-60.4401.00-37.42 A

ATOM 4409-θ EYS-A572 -27.957-22.13-8-61.1471:0.037.20 A

ATOM 4410 N TYR A 573 -26:873 -22.027 -59rl 891.0037.92 A

ATOM 4411 CA TYR A 573 -27.898-21.206-58.593 1.0037.61 A

ATOM 4412 CB TYR A 573 -27.810-21.272-57.0641.0036.20 A ATOM 4413 CG TYR A 573 -28.863-20.427-56.3661.0034.61 A

ATOM 4414 CDl TYR A 573 -30.074-20.983-55.9601.0034.39 A

ATOM 4415 CEl TYR A 573 -31.053-20.204-55.355 1.0034.03 A

ATOM 4416 CD2 TYRA 573 -28.660-19.062-56.1471.0032.57 A

ATOM 4417 CE2 TYRA 573 -29.632-18.276-55.551 1.0031.89 A _5U

ATOM 4418 CZ TYRA 573 -30.828-18.845-55.1591.0033.58 A

ATOM 4419 OH TYRA 573 -31.817-18.036-54.6171.0033.95 A

ATOM 4420 C TYRA 573 -27.678-19.776-59.0521.0038.56 A

ATOM 4421 O TYRA573 -28.568 -19.T52 -59.626 1.0039.07 A ATOM 4422 N- -PHE A 574 -26.468-191286-58.810 1.0039.16 A

ATΘM 4423 CA PHE A 574 ~26.HO -17.9-17 -59.1571.0040.00 A

ATOM 4424 CB PHE A 574 -24.964-17.429-58.2621.0040.48 A

ATOM 4425 CG PHE A 574 -25.318-17.336-56.8201.0040.05 A

ATOM 4426 CDl PHE A 574 -24.986 -18.3-55 -55.935 1.0039.91 A ATOM^" 4427 CD2 PHE A 574 -25.971-16.211-56.338 1.0040.07 A

ATOM- 4428 CE1-PHEA574 -25.296 -18,242 -54.58-71.0039.20 A

ATOM 4429.CE2.PHE A 574 -26:284 -16.09J -J5.003 1.0039.09 A

ATOM 4430 CZ PHE A 574 -25.945-17.102-54.1241.0039.84 A

ATOM 4431 C PHEA-574 -25.636-17.715-60.5771.0040:03 A ATOM 44320 PHE A 574 -25.150-16_^628-60.925 1.0040.73 A

ATOM 4433 N GLN A 575 -25.741-18.735-61.3981.0038.81 A

ATOM 4434 CA GLN A 575 -25.193-18.580-62.723 1.0037.84 A

ATOM 4435 CB GLN A 575 -25.697-19.626-63.659 1.0036J0 A

ATOM 4436 CG GLNA575 -24:623-19.926-64.601 1.0036.01 A ATOM 4437 CD GLN A 575 -24.549-21.385-64.738 1.003:6.34 A

ATOM 4438 OEl- GLN A 575 -23.577-22.020-64.9621.0037.03 A

ATOM 4439 NE2 GLN-A-575 -23.3156 -21.955-64.55-71,0035,24 A

-ATΘM-444J0 C GLN-A575: -25.325 -17.286-.-63.482 1.0037.59 A

ATOM 4441. Θ_ GEN-A 575 -24.346--16.744 -63.978 fcGO 3X28 A ATOM 4442 N PRO A- 576 -26τ556 -16T78O.-63.6091.00^"37.47 A-

ATOM 4443-CD .P-RO A 576 -27.839 -l-7τ3K--63.1-i 91.00-38.20 A

ATOM^" 4444 CA PRO-A-576 -26.756 -15-.536 -64.348-1.0037:01 A

ATOM 4445 CB PRO A 576 -28.248-15.277-64.2071.0036.40 A

ATOM 4446- CG PRO A 576 τ28.825 -16^659 -64.0381.0037.62 A ATOM 4447 C PRO A 576 -25.926 -14.373 -63.8581.0036.73 A

ATOM 4448 O PRO A 576 -25.108-13.843-64.601 1.0037.21 A

ATOM 4449 N VAL A 577 -26.139-13.969-62.6141.0037.14 A

ATOM 4450 CA VAL A 577 -25.416-12.830-62.0541.0036.90 A

ATOM 4451 CB VAL A 577 -25.931-12.514-60.643 1.0037.62 A _m

ATOM 4452 CGl VAL A 577 -25.399-13.546-59.661 1.0038.83 A

ATOM 4453 CG2VALA577 -25.522-11.114-60.2371.0038.33 A

ATOM 4454 C VAL A 577 -23.915-13.119-62.013 1.0036.43 A

ATOM 4455 O VAL A 577 -23.096-12.193-62.036 1.0034.63 A ATOM 4456- N THRA578 -23.564 -14,407- --61:949 LOO 35.41 A

ATOM 4457 CA THR A 578^" -22.162-14.817-61.934 1.00-35.05^" A

ATOM 4458 CB THR A 578 -22.006-16.354-61.9071.0036.94 A

ATOM 4459 OGl THR A 578 -22.272-16.846-60.588 1.0036.52 A

ATOM 4460 CG2THRA578 -20.588-16.757-62.341 1.Θ037.48 A ATOM 4461 C THRA 578 -21.493-14.322-63.2021.0033.33 A

ATOM 4462 O THR A 578 -20.377-13.823-63.1-81 1-0035.14 A

ATOM 4463 N GLNA 579 -22.185-14.486-64.3171.0030.44 A

ATOM 4464 CA GLN A 579 -21.655-14.061-65.5891.0027.05 A

ATOM 4465 CB GLN A 579 -22.389 -14.790 -66 J121.0024.86 A ATOM 4466 CG GLN A 579 -21.496-15.652-67.5871.00^"2477O A

ATOM 4467 CD GLN A 579 -20.847-16.786-66.851 1.0025.42 A

ATOM 4468 OEl GLNA 579 -21.526-17.611-66.232 1.0026.71 A

ATOM 4469 NE2 GLN A 579 -19.518-16.852-66.9201.0026.10 A

ATOM 4470 C GLN A 579 -2L830 -12.556 -65.70» 1.0025.65 A ATOM 4471 O GLN A 579 -20.955-11.865-66.2091.0026.98 A

ATOM 4472 N TRP A 580 -22.954 -12.ΘH8 -65.2191.00-24T25 A

ATOM 4473 CA TRP A 580 -23.249 -10.624-63293¹1.0023.72^' A.

ATOM 4474- CB TRP A 5.8D -24=615-10.332-64,6951.0024,18- A

ATOM 4475 CG- TRP A 580 -24.986 -8,8SO --6_t772 1.0024.51 A- ATOM 4476 CD2TRPA580 -24.733 -7:873^63,786^" 1.0025.82 A-

ATΘM, 4477 CE2TRPA5SΘ -25.2X5 -6.653,-64.3071.0024.58 A

ATOM 44-78 CE3 TRP- A-580 - -24:146 -7.-8S1 -62.51L_l.Q02-8.22 A

ATOM 4479 CDl TRP A 580 -25.588 -8.252 -65.8071.00^{^}22.89 A

ATOM 4480 NEl TRP A 580 -25.730 -6.920-65.543 1.0022.79 A ATOM 4481 CZ2TRPA580 -25.133 -5.450 --63.605 1.0024.82 A

ATOM 4482 CZ3 TRP A 580 -24.064 -6.678-61.808 1.0028.70 A

ATOM 4483 CH2TRPA580 -24.558 -5.480-62.361 1.0027.73 A

ATOM 4484 C TRP A 580 -22.223 -9.748-64.595 1.0025.48 A

ATOM 4485 O TRP A 580 -21.742 -8.774-65.168 1.0025.20 A ATOM 4486 N LEUA 581 -21.917-10.073-63.341 1.0027.57 A

ATOM 4487 CA LEU A 581 -20.942 -9.307-62.5671.0026.98 A

ATOM 4488 CB LEUA 581 -20.793 -9.920-61.173 1.0026.82 A

ATOM 4489 CG LEU A 581 -21.896 -9.560.-60.1701.0025.05 A

5 ATOM 4490 CDl LEU A 581 -21.738-10.375 -58.908 LOO 2,1.58 A

ATOM 4491 CD2LEUA581 -21.834 -8.073-59.857 r.OQ-23.93 A

ATOM 4492 C LEUA 581 -19.605 -9.337-63.300 1.0028.08 A

ATOM 4493 O LEU A 581 -18.957 -8.311-63.555 1.0028.35 A

ATOM 4494 N GLNA582 -19.218-10.547-63.656 T.0028.05 A

10 ATOM 4495 CA GLN A 582 -17.984-10.772-64.364 1.0027.95 A

ATOM 4496 CB GLNA 582 -17.945^~-12.219 -64.7441.0027.25 A

ATOM 4497 CG GLN A 582 -16.664 -12.867 -64.481 l-00_27.29 A-

ATOM 4498 CD GLN A 582 -16.741-14.300-64.9091.0027.75 A

ATOM 4499 OEl GLN A 582 -15.792-14.848-65.4721,0029.80 A

15 ATOM 4500 NE2 GLN A 582 -17.893-14.921-64.6671.0026.44 A

ATOM 45Θ1 C GLN A 582 -17-837 -9.901-65.6061.0029.01 A

ATOM 4502 O GLN A 582 -16.765 -9.382-65.905 1.0030.29- A

ATOM 4503 N GLU A 583 -18.935 -9.743-66,3301.0028.94 A

ATOM 4504 CA GLU A 583 -18.932 -8.925-67.535 1.0027,41 A

20 ATOM 4505 CB GLU A 583 -20.178 -9.206-68.395 1.0027.96 A

ATOM^" 4506 CG- GLU A 583 -20.303 -8.303-69,6341.0031.84 -A

ATOM 4507 -CD GLU A 583 -19.449 -8.743-70.8261.0032.16 A

ATOM 4508 OEl GLUA 583 -18,354 -9.330-70,6431,00^1,03 A

ATOM 4S09 ΘE2 GLUA- 5S3 -I9J.885 -&4-T5 -7E961 1.0034.08 A-

-25_ ATOM -4510 C-. GLU-A 583- -18.8-57 -7.442 -67.191 k0026.19 A

ATOM 4511 O GLU A 583 - l*dt#7 -6.684r-67-.8741.0027.32 A-

ATOM 4512 N GLN-A-?84 -T9.520 -7.029-66.116 l.OO 24.80- A

ATOM 45-13 CA GLN A 584 -19.508 -5.614 -65.71-3 1.0023L12 A

ATOM 4514 CB GLN A 584 -20.536 -5.342-64.6421.00-23.20 A

30 ATOM 4515 CG GLN A 584 -21.933-5.455-65.093 1.0025.69 A

ATOM 4516 CD GLN A 584 -22.485 -4.117-65.5361.0027.04 A

ATOM 4517 OEl GLN A 584 -22.628 -3.189-64.729 1.0025.73 A

ATOM 4518 NE2 GLN A 584 -22.790 -3.999-66.828 1.0027.48 A

ATOM 4519 C GLNA 584 -18.219 -5.087-65.1671.0023.04 A ATOM 4520 O GLN A 584 -17.917 -3.909-65.3121.0022.14 A

ATOM 4521 N ASN A 585 -17.468 -5.952-64.501 1.0023.75 A

ATOM 4522 CA ASN A 585 -16.226 -5.497-63.9061.0024.81 A

ATOM 4523 CB ASN A 585 -15.679 -6.506-62.883 1.0026.04 A

5. ATOM 4524 CG ASN A 585 -16.510 -6.560-61.615 1.0025.81 A

ATOM 4525 ODl ASN A 585 -16.955 -5.522-61.108 1.0026.89 A

ATOM 4526 ND2 ASN A 585 -16.716 -7.765-61.091 1.0024.05 A

ATOM 4527 C ASN A 585 -15.227 -5.259-64.9961.0024.73 A

ATOM 4528 O ASNA 585 -14.564 -4.217-65.043 1.0025.57 A 0 ATOM 4529 N GLNA 586 -15.148 -6.230-65.8941.0024.36 A

ATOM 4530 CA GLN A 586 -14.238 -6.134 -67.0.141.0023.49 A

ATOM 4531 CB GLN A 586 -14.437 -7.336-67.936 1.0023.76 A

ATOM 4532 CG GLN A 586 -13.208 -7.721-68.7171.0025.72 A

ATOM 4533 CD GLN A 586 -13,118 -6.994-70.046 LOO 26.67 A 5 ATOM 4534 OEl GLN A 586 -14.133 -6.805-70.7241.0026.19 A

ATOM 4535 NE2GLNA586 -11.899 -6.595-70:4361.0026,57 A

ATOM 453:6 C GLN A 586 -L4.476 -4.828 -67.7641.0022.34 A

ATOM 4537 O GLNA 586 -13.611 -3.958-67.8041.0022.05 A

ATOM 4538 N GLNA 587 -15.658 -4.668 -68.340 1.0021.05 A 0 ATOM 4539 CA GLN A 587 -15.909 -3.438-69.075 1.0020.99 A

ATOM 4540 CB GLN. A 587 -17.383 -3.295-69.4621.0021.02 A

^'ATOM- 4541 CG GLN A 587 -18.162 -4.560-69.3831.ΘG-21.47 A

ATOM 4542 CD GLN A-5.87 -15.322 -4.571 -79:3261,0023.33 A ATOM^" 4543 OEl GLN-A 587^" -1S.172^" -4.938 -71.4801.0027.32 A 5 ATOM 4544 NE2 GLN-A 5S7- -2Gr489 -iU 55 -69r852 kOΘ 24.21 A

ATOM 4545 C GLN A 587 -15.466 -2.222-68.2671.0Θ-20-JB9- A

ATOM 4546 O GLN A 587 -14.691 -L399 -68.763^~L.002T08 A

ATOM 4547 N ASN A- 588 -15.930 -2.120-67,0201.0020.04 A

ATOM 4548 CA ASN A 58S- -15.550 -0.993-66.1821.0018.04 A 0 ATOM 4549 CB ASNA 588 -16.505 -0.853 -65.0171.001.8.11 A

ATOM 4550 CG ASN A 588 -17.812 -0.250-65.4291.0020.06 A

ATOM 4551 OD1ASNA588 -18.013 0.968-65.332 1.0021.10" A

ATOM 4552 ND2 ASN A 588 -18.713 -1.093-65.926 1.0021.37 A

ATOM 4553 C ASNA 588 -14.124 -1.023-65.678 1.0017.52 A ATOM 4554 O ASN A 588 -13.786 -0.294-64.7861.0018.95 A

ATOM 4555 N GLY A 589 -13.299 -1.879-66.257 1.0018.49 A

ATOM 4556 CA GLY A 589 -11.888 -1.95.9-65.909 1.0019.45 A

ATOM 4557 C GLY A 589 -11.483 -2.240-64.476 1.0019.67 A ATOM 4558 O GLY A.589 -10.386 -1.894-64.032 1.0020.64 A

ATOM 4559 N GLU A 590 -12.359 -2.896-63.739 1.0019.76 A

ATOM 4560 CA GLU A 590 -12.036 -3.226-62.3641.0019.21 A

ATOM 4561 CB GLU A 590 -13.219 -3.866-61.6801.0018.69 A

ATOM 4562 CG GLU A 590 -13.541 -3.093-60.4901.0019.19 A ATOM 4563 CD GLU A 590 -14.275 -1.844-60.8961.0019.92 A

ATOM 4564 OEl GLU A 590 -13-718 -0.724-60.824 LOO 19.96 A

ATOM^' 4565 OE2GLUA590 -15..431 -2.025-61.-3181.0021.81 A

ATOM 4566 C GLU A 590 -10.850 -4.135-62.128 1.0018.58 A

ATOM 4567 O GLU A 59.0 -10.367 -4.803-63.025 1.001-8.46 A ATOM 4568 N VAL A 591 -10.395 -4.169 -60.88& 1.0018.94 A

ATOM 4569 CA VAL A 591 -9.292 -5.040 -60.5471.0019.79 A

ATOM 4570 CB VAL A 591 -8.110 -4.277-59.918 1.0019.25 A ATOM 4571 CGl -VAL A 591 -6.998 -5.251-59.5641.0019.12 A ATOM 4572 CG2 VAL A 591 -7.585 -3.264-60.8971.0020.21 A ATOM 4573 C VAL A 591 -9.780 -6.077-59.553 1.0020.15 A

ATOM 4574 O VAL A 591 -10.122 -5.748-58.4291.00^"21.49 A

ATOM 4575 -N- LEU A 59.2 -9:836-7.332-59:9641.0020.76 A

ATOM 4576 CA LEU A592 -10.267 -8.363-59.041 1.00-21.17 A-

ATGM 457:7^" CB LEU A.592- -1Φ.532 -9.685 -59.773 L^"0019.89- A ATOM 4578 CG LEU A 592 -11.591 -9.582 -6CL&64 hGO 19.77^~ A^"

ATOM 4579 CDl LEU A 592 -1L826- 10.947 -61.4791.0020.-68 A

ATOM 4580 CBS LEU A 592 -12:875 -9.014 -60.2851.0018.95 A

ATOM 4581 C LEU A 592 -9.165 -8L5.49--58.0G-1 1.0021.64 A

ATOM 4582 O LEU A 592 -8.000 -8.818-58.335 1.002L11 A ATOM 4583 N GLY A 593 -9.555 -8.384-56.7361.0021.69 A

ATOM 4584 CA GLY A 593 -8.626 -8.532-55.6261.0020.70 A

ATOM 4585 C GLY A 593 -8.032 -7.234-55.068 1.0019.39 A

ATOM 45860 GLY A 593 -8.429 -6.139-55.442 1.0019.23 A

ATOM 4587 N TRP A 594 -7.081 -7.359-54.1541.0018.86 A ATOM 4588 CA TRP A 594 -6.405 -6.212 -53.557 1.00 17.99 A

ATOM 4589 CB TRP A 594 -6.744 -6.045 -52.056 1.00 15.33 A

ATOM 4590 CG TRP A 594 -7.078 -7.324 -51.345 1.00 13.19 A

ATOM 4591 CD2 TRP A 594 -8.220 -8.140 -51.589 1.00 9.81 A

ATOM 4592 CE2 TRP A 594 -8.1D -9.277 -50 J-59 1.00 9.83 A

ATOM 4593 CE3 TRP A 594 -9.325 -8.024 -52.435- 1.00 8.56 A

ATOM 4594 CDl TRP A 594 -6.337 -7.970 -50.389 1.00 12.44 A

ATOM 4595 NEl TRP A 594 -6.955 -9.147 -50.034 1.00 11.36 A

ATOM 4596 CZ2 TRPA 594 -9.083 -10.300 -50.754 1.00 8.27 A

ATOM 4597 CZ3 TRP A 594 -10.284 -9.034 -52.431 1.00 7.89 A

ATOM 4598 CH2 TRP A 594 -10.157 -10.156 -51.596 LOO 7.54 A

ATOM 4599 C TRPA 594 -4.921 -6.436 -53.720 1.00 18.11 A

ATOM 4600 O TRP A 594 -4.351 -7.350 -53.127 1.00 19.99 A

ATOM 4601 N PRO A 595 -4.303 -J .664 -54.611 1.00 16.51 A

ATOM 4602 CD PRO A 595 -4.998 -5.1S7 -55.811 1.00 15.94 A

ATOM 4603 CA PRO A 595 -2.874 -5.773^" -54.854 1.00 14.72 A

ATOM 4604 CB PRO A 595 -2.743 -5.413 -56.325 LOO 14.66 A

ATOM 4605 CG PRO A 595 -3.898 -4.540-56.579 1.0015.73 A

ATOM 4606 C PRO A 595 -2.196 -4.804 -53.919 LOO 14.82 A

ATOM 4607 O JPRO A 595 -1.060 -5.027 -53.501 1.00 13.95 A

ATOM 4608 N GLU A 596 -2.914 -3.736 -53.573 1.00 14.53 A

ATOM 46O9- CA GLU A 596 -2.392 -2.751 -52.645 1.00 15.24 A

ATOM -4610 CB GLUA596 -2.898 -1.341 -52.974 1.00 17.86 A

ATOM 4611 €G_GLU A 596 -2.232 -0.703-54.182_-1.0023.83 A

ATOM 4612 CD GLU A-596 -2.571 OC761--54.350 1.00J26.46 A

ATOM 4613 ΘE1 GLUA.596 -3.134 1345- -53.393 1.00.29.87 A

ATOM 4614 OE2X3LU A 596 -2.264 1.319 -55.431 L002&19 A

ATΘM 4615 C GLU A 596 -2.800- -3.127 -51.218 1.00 14.44 A

ATOM 4616 O GLU A 596 -3.462 -2.370 -50.522 1.00 13.51 A

ATOM 4617 N TYRA 597 -2.430 -4.332 -50.806 1.00 14.28 A

ATOM 4618 CA TYR A 597 -2.700 -4.798 -49.457 LOO 13.29 A

ATOM 4619 CB TYR A 597 -2.131 -6.215 -49.281 1.00 13.32 A

ATOM 4620 CG TYR A 597 -0.626 -6.266 -49.364 1.00 13.04 A

ATOM 4621 CDl TYR A 597 0.152 -5.878 -48.291 1.00 14.71 A _51?

ATOM 4622 CEl TYR A 597 1.539 -5.814-48.382 1.0015.62 A

ATOM 4623 CD2TYRA597 0.023 -6.606-50.5391.0014.55 A

ATOM 4624 CE2TYRA597 1.428 -6.544-50.6361.0015,60 A

ATOM 4625 CZ TYR A 597 2.168 -6.143-49.5491.0014.49. A ATOM 4626-OH TYR A^~597 3.532 -6.040-49.6001.0015.84 A

ATOM 4627 C TYRA 597 -1.858 -3.798-48.6961.0013.67 A

ATOM 4628 O TYRA 597 -1.051 -3.107-49.3141.0017.20 A

ATOM 4629 N GLN A 598 -2.004 -3.703-47.3871.0010.84 A

ATOM 4630 CA GEN A 598 -1.198 -2.741-46.6341.0010.57 A ATOM 4631 CB GLN A 598 0.255 -2.706-47.161 1.00^.06 A

ATOM 4632 CG GLN A 598^" 1.179 -1.663-46.5081-.00 «.26 A

ATOM 4633 CD GLN A 598^" 2.656 -1.798-46.931 1.009.22 A

ATOM 4634 OEl GLN A 598 3.521 -1.051-46.4791.008.16 A

ATOM 4.635 NE2 GLNA 598 2.937 -2.759-47.7901.0011.83 A ATOM 4636 C GEN A 598 -1.801 -1.337-46.6571.001-0.80 A

ATOM 4637 O GLN A 598 -1.369 -0.475-45.9091.001-5.12 A

ATOM 463 S N TRPA 599 -2.809-1.104-47.4871.0010.02 A

ATOM 4639 CA TRP A 599 -3.424 0.216-47.5481.0011.03 A

ATOM 4640 CB TRPA 599 -4.104 0.463-48.891 1.007.32 A ATOM 4641 CG TRP A 599 -4.892 1.761.-48.911 1.002.13 A

ATOM 4642. CDZTR-PA 599 -6.364 1.920-48.6901.001.00 A

ATOM.4643 CE2TRPA599 -6.58-1 3302-48.7361.00 LOO A

ATOM- 4644 CE3 TRP A 599 -7.362 1,026-48.4521.00-1,00 A

ATOM-4645 CDl TRP A 599 -4.392 3.013-49.07-71.001.57^" A ATOM 4646 NEl TRP A÷599 -539.6 37944 -48.976- 1.001.00 A

ATOM 4647 CZ2TRPA-599- -7:878 3.823-48:551 h001,00 A_

ATOM- 4J648-XZ3TRPA599 -8.653 1:541-48.2661.00 LOO A-

ATOM 4649 CH2TRPA599 -8.897 2.929-48.3161.00 1.00 A

ATOM 4650 C TRP A 599 -4.489 0.371-46.491 1.0014.25 A ATOM 4651 O TRP A 599 -5.280 -0.553-46.2781.0017.77 A

ATOM 4652 N HIS A 600 -4.539 1.543-45.8561.0014.78 A

ATOM 4653 CA fflS A 600 -5.551 1.801-44.8421.0014.29 A

ATOM 4654 CB HIS A 600 -4.973 1.683-43.423 1.0017.51 A

ATOM 4655 CG HIS A 600 -4.649 0.279-43.0061.0020.21 A ATOM 4656 CD2 HIS A 600 -5.313 -0.589 -42.204 1.00 20.54 A

ATOM 4657 M)I fflS A 600 -3.528 -0.393 -43.450 1.00 21.92 A

ATOM 4658 CEl HIS A 600 -3.518 -1.613 -42.941 1.00 22.11 A

ATOM 4659 NE2 HIS A 600 -4.590 -1.757 -42.181 1.0020.94 A ATOM 4660 C HIS A 600- -6.128 3.1=76 -45.029 1.00 13.64 A

ATOM 4661 Θ HIS A 600 -5.426 4.H-6 -45.407 l^".00:I1.65 A

ATOM 4662 N PRO A 601 -7.424 3.314 -44.758 1.00 14.43 A

ATOM 4663 CD PRO A 601 -8.369 2.294 -44.277 1.00 14.41 A

ATOM 4664 CA PRO A 601 -8,106 4.593 -4^'4.896 1.00 16rl3 A ATOM 4665 CB PRO A 601 -9.573 4:199 -44.813 1.00 15:15 A

ATOM 4666 CG PRO A 691 -9.538 3.142 -4-3,8:1=6 1:00 13.09 A

ATOM 4667 C. PRO A 60-1 -7.745 5.510-43.764 1.00 1:8.22 A

ATOM 4668 O PRO A 601 -7.376 5.054 -42.684 1.00 19.37 A

ATOM 4669 N PRO A 602 -7.822 6.818 -44.008 1.00 19.85 A ATOM 4670. CD PRO A-602 -7.845 7.466 -45.327 1.0020.19 A

ATOM 4671 CA PRO A 602 -7.502 7.786 -42.970 1.00 20.82 A

ATOM 4672 CB PRO A 602 -7.064 9.002 -43.751 1.00 19.20 A

ATOM 4673 CG PRO A 602 -7.936 8.937 -44.952 1.00 19.60 A

ATOM 4674 C PRO A 602 -8.708 8.061 -42.162 1.0022.58 A ATOM 4675 O PRO A 602 -9.844 7.927 -42.660 1.0024.11 A

ATOM 4676 N LEU A-6Θ3- -.8.458 8.473 -40τ94:6 1.0024.16 A

ATOM 4677 CA LEU A 603 -9.520 -8.774 -40:θ5σ 1.0025.66 A

ATOM- 4628 GB LEU A 603 -8.985 9.351 -3S-.743 LOD-24.77 A

-ATOM 4679 CG LEU A--6Θ3 _^8:177 8.523 -37:807 1.0023.68 A. ATOM 468Oi CDl LEU A 603 -7.660 9,390 -36,665- 1.0022.98 A^"

ATOM 4681 CD2 LEUA 603- -9.121 7.497 -37.323 1:00 23:04- A

ATOM 4682 C LEU A 603 -10.249 9.926-40.620 1.0027.45 A

ATOM -4683 O LEU A 603 -9.759 10.6 IO -41.480 1.00-27.83 A

ATOM 4684 N- PRO A604 -11.437 10.176 -40.084- 1.00 30.49 A ATOM 4685 CD PRO A 604 -12.345 9.047 -39.883 1.00 31.45 A

ATOM 4686 CA PRO A 604 -12.213 11.296 -40.528 1.00 33.74 A

ATOM 4687 CB PRO A 604 -13.467 11.206 -39.652 1.00 32.51 A

ATOM 4688 CG PRO A 604 -13.753 9.736 -39.728 1.00 32.28 A

ATOM 4689 C PRO A 604 -11.354 12.47 '6 -40.239 1.00 37.73 A ATOM 4690 O PRO A 604 -10.171 12.368 -40.104 1.00 39.57 A

ATOM 4691 N ASP A 605 -12.024 13.602 -40.186 1.0041.82 A

ATOM 4692 CA ASP A 605 -11.396 14.903 -40.045 1.00 45.34 A

ATOM 4693 CB ASP A 605 -12.309 15.848 -40.747 1.0047.73 A ATOM 4694 CG ASP A 605 -11.977 15:93.7 -42.244 1,00-49:64 A-

ATOM 4695 ODl ASF A 605 -12.402 15.119 -43.132 LOO 5L46 A-

ATOM 4696 OD2 ASP A 605 -11.188 16.855 -42.527 1.00 50.18 A

ATOM 4697 C ASP A 605 -10.816 15.509 -38.742 1.0046.53 A

ATOM 4698^' O ASP A 605 -9.814 16.248 -38.752 1.0046.38 A ATOM 4699 N ASN A 606 -11.548 15.295 -37.662 1.0048.38 A

ATOM 4700 CA ASN A 606 -11.111 15.565-36.299 1.00 49.24 A

ATOM 4701 CB ASN A 606 -11.290 16^79 -35J776- LOO 50.76 A

ATOM 4702 CG ASN A 606 -9.987 17.767 -35.891 1.00 53.11 A

ATOM 4703 ODl ASNA 606 -8.880 17.208 -35.780 1.0Θ 54JL7 A ATOM 4704 M)2 ASN A 606 -10.108 19.053 -36.146 LOO 54.82 A

ATOM 4705 C ASN A 606 -11.951 14.529 -35.633 1.0049.40 A

ATOM 4706 O- ASN A 606 -13.161 14.63S -35.477 1.0049.80 A

ATOM 4707 N TYRA 607 -11.250 13.446 -35.337 1.0048.42 A

ATOM 4708 CA TYR A 607 -11.875 12.300 -34.718 1.0047.93 A ATOM 4709 CB TYR A 607 -11.528 11.069 -35.572 1.00 44.06 A

ATOM 4710 CG TYRA 607 -12.428 9.874 -35.4GΘ- LOO 39.59 A

ATOM 4711 GDI TYR A 607 -13;776 9.946 -35.717 1.0037.70- A

ATOMr 471-2 CEl TYH A 607 -14.60.8, 8τ85S~35.551 1.00-36.35 A

ATOM 4713 CDZTYR A307- -11,923 8.665 -34.-910- 1.00-37,64 A ATOM- 4714^CE2 TYR A 607 -12.743 7.564 -34.738 LΘΘ-36,04- A

ATOM 4715 CZ TYRrA 607 —14.091 7,668 -35:059 LOB 36:65 A

ATOM ^"4716 OHT TYRA 607 -14:927 6.589 -34.869 1.00^~36.19 A

ATOM 4717 C TYR A 607 -11.423 12.009 -33.287 1.00 5036- A

ATOM 4718 O TYR A 607 -10.240 11.954 -32.981 1.00 51.37 A ATOM 4719 N PRO A 608 -12.403 11.795 -32.384 LOO 51.76 A

ATOM 4720 CD PRO A 608 -12.100 10.955 -31.196 1.00 52.16 A

ATOM 4721 CA PRO A 608 -13.821 11.678 -32.735 1.00 53.64 A

ATOM 4722 CB PRO A 608 -14.166 10.287 -32.305 1.00 52.45 A

ATOM 4723 CG PRO A 608 -13.360 10.145 -31.018 1.00 52.59 A ATOM 4724 C PRO A 608 -14.797 12.709 -32.125 1.00 56.66 A

ATOM 4725 O PRO A 608 -15.267 12.514 -31.012 1.00 57.88 A

ATOM 4726 N ALA A 609 -15.123 13.763 -32.860 1.00 59.66 A

ATOM 4727 CA ALA A 609 -16.095 14.753 -32,389 LOO 62.41 A ATOM 4728 CB ALA A 609 -15.395 15.995 -31.831 1.00 61.08 A

ATOM 4729 C ALA A 609 -16.951 15.106 -33.603 1.00 64.44 A

ATOM 4730 O ALA A 609 -16.617 16.009 -34.386 1.00 65.30 A

ATOM 4731 N GLY A 610 -18.032 14.343 -33.780 1.00 66.30 A

ATOM 4732 CA GLY A 610 -18.911 14.537 -34.926 1.00 68.34 A ATOM 4733 C GLY A 610 -20.447 14.614 -34.780 1.00 70.36 A

ATOM 4734 O GLYA 610 -20.952 15.359 -33.961 1.00 71.51 A

ATOM 4735 N ALA A 611 -21.202 13.871 -35.611 1,00 71.42 A

ATOM 4736 CA ALA A 611 -22.736 13.882 -35.670 1.00 72.72 A

ATOM 4737 CB ALA A 611 -23.163 13.640 -37.039 1.00 72.75 A ATOM 4738 C ALA A 611 -23.064 127732 -34.731 1.00 73.60 A

ATOM 4739 O ALAA 611 -24.178 12.445 -34.243 1.00 74.05 A

ATOM 4740 N ALA A 612 -21.972 12.049 -34.958 1.00 74.11 A

ATOM 4741 CA ALA A 612 -21.273 11.072 -34.163 1.0074.24 A

ATOM 4742 CB ALA A 612 -22.007 10.136 -33.096 1.00 73.63 A ATOM 4743 G ALA A 612 -20.223 10.444 -34.981 1.00 74.24 A

ATOM 4744 O- ALAA 612 -19.243 11.153 -35.210 1.00 73.79 A ATOM 4745 ZN+2 ZN2-A 701 -27.724 -2-2.055 -36.604 LSO 41.65 A

ATOM 4746 GL CL A7_02 -28rl01 -18.465 -91.428 1,0032.55 A

ATOM 4747-Cl NAG A 691 -3.037 0.333129.182 kθO 34722^" A ATOM 4748=C2 NAG A_691 -K-632 0:801 -28.782 1.00 33.25 A

ATOM 4749 C3 NAG A 691 -1.860 2.0-45 ~2M 30 LOO 34.93 A

ATOM 4750 C4 NAG-A.691 -2:55» 2.975^"-28τ922 1.00 36.91 A

ATOM 4751 C5 NAG A 691 -3.771 2.539-29.253 1.00 36.60- A

ATOM 4752 C6 NAG A 691 -4.399 3.909 -29.786 1.00 36.92 A ATOM 4753 C7 NAG A 691 -0.186 -0.668 -27.684 1.0032.79 A

ATOM 4754 C8 NAG A 691 -0.061 -1.112 -26.501 1.00 32.53 A

ATOM 4755 N2 NAG A 691 -1.182 0.111 -27.725 1.00 32.84 A

ATOM 4756 03 NAG A 691 -0.665 2.685 -27.681 1.00 35.82 A

ATOM 4757 04 NAG A 691 -2.795 4.001 -28.298 1.00 38.64 A 52

ATOM 4758 05 NAG A 691 -3.458 L330 -30.1291-0035.00 A

ATOM 4759 06 NAG A 691 -5.762 3.704-30.161 1.0037.39 A

ATOM 4760 07 NAG A 691 0.575 -0.974-28.611 1.0034.87 A

ATOM 4761 Cl NAG A 693 -34.828-42.696-23.171 1.0073.93 A

ATOM 4762 C2 NAG A 693 -36.209-42.149-23.3471.0074.24 A

ATOM 4763 C3 NAG A 693 -37.066-43:252-23.9481.0074.48 A

ATOM 4764 C4 NAG A 693 -36.439-43.869-25.193 1.0074.92 A

ATOM 4765 C5 NAG A 693 -35.057-44.430-24.8341.0074.47 A

ATOM 4766 C6 NAGA 693 -34.368-45.041-26.061 1.0073.79 A

ATOM 4767 C7 NAG A 693^" -36.590-42.892-20.975 1.0075.21 A

ATOM 4768 C8 NAG A 693 -37.057 -42.556 -19.8091.0074.84 A

ATOM 4769 N2 NAG A 693 -36.684-41.929-21.975 1.0074.70 A

ATOM 4770 03 NAG A 693 -38.348-42.718-24.208 1.0073.79 A

ATOM 47Jl 04 NAG A 693 -37285-44.903-25.6741.0076.15 A

ATOM 4772 05 NAG A 693 -34304-43.329-24.363 1.0074.07 A

ATOM 4773 06 NAG A 693 -33.-075-45.538-25.723 1.0072.93 A

ATOM 4774 O7 NAG A 693 -36.105^" -44.027 -21.1-101.0075,95 A

ATOM 4775 Cl NAG A 695 -15.124-13.831-13.6971.0075.31 A

ATOM 4776 C2 NAG A 695 -13.817-14.389-13.038 1.0075.99 A

ATOM 4777 C3 NAG A 695 -14.255-1-4.895-11.7921.0076.42 A

ATOM 4778 C4 NAG A 695 -14.920-13.815-10.9721.0076.85 A

ATOM 4779 C5 NAG A 695 -16.185 -1-3.297 -11.7L81.0076.11 A-

ATOM 4780 C6 NAG-A 695 -161S83 -12.219^" -105561.00=76:32 A

ATOM 4=7:81- C7 -NAG A 695 -12.561 -16.06.7-14:495-1.0074.90 A

ATOM- 47_82 C8 NAG A 695 -12.314-47.445 -14.59.3 - 1.0074τ74 A^'

ATOM- 4783 N2 NAGA 695 -13348-15.704,-13.5071.0075.31 A-

ATOM 4784 03 -NAG A 695 -13.122-15.385-11.223 1,0077.06^' A

ATOM 4785 04 NAG A69-5 -15.293 -14.409 -9,7321.0077.5^'5 A

ATOM 4786 05 NAG A 695 -15.789-12.769-12.9561.0075.35 A

ATOM 4787 06 NAG A 695 -18.001-1.1.816-11.7071.0076,68 A

ATOM 4788 07 NAG A 695 -12.087-15.327-15.243 1.0075.02 A

ATOM 4789 Cl NAG A 696 -3.457 5.301-26.546 1.00101.83 A

ATOM 4790 C2 NAG A 696 -2.964 6.686-26.2541.00102.79 A

ATOM 4791 C3 NAG A 696 -3.888 7.206-25.175 1.00102.90 A ^

ATOM 4792 C4 NAG A 696 -5.350 7.193-25.693 1.00102.52 A

ATOM 4793 C5 NAG A 696 -5.758 5.761-26.0521.00102.20 A

ATOM 4794 C6 NAG A 696 -7.189 5.685-26.5881.00102.41 A

ATOM 4795 C7 NAG A 69.6 -0.567 7.252-26.2281.00104.49 A ATOM 4796 C8 NAG A 696 0.608 7.036-25:6671.00104.44 A

ATOM 4797 N2 -NAG A 696 -1.612. 6.556-25.7161.00104.00 A

ATOM 479803 NAG A 696 -3.496 8.509-24.845 1.00103.56 A

ATOM 479904 NAG A 696 -6.235 7.664-24.7101.00102.63 A

ATOM 4800 O5 NAG A 696 -4.824 5.307-27.038 1.00101.44 A ATOM 4801 O6 NAG A 696 -7.505 4.333-26.920 1.00103.51 A

ATOM 4802 Θ7 NAG A 696 -0.652 8.040-27.163 1.00104.62 A

ATOM 4803 Ol LPRA- 705 -24.780-17.055-35.025 1.0051.85 A

ATOM 4804 O2 LPR A 705 -28.280-20.333-34.8371.0048.97 A

ATOM 4805 O3 LPR-A 705 -26.292.-21.183-34.7751.0051.15 A ATOM 4806 Θ4 LPR A 705 -22.630.-15,172-36.8621.0047.18 A

ATOM 480705 LPR A 705 -24.479-14.213-37.5791.0046.74 A

ATOM 4808 Nl LPR A 705 -27.106-18.081 -33..8781.0049.72 A

ATOM 4809 N2 LPRA 7Θ5 -25,611-16.977-37.2141.0049.51 A

ATOM 4810 N3 LPR A 705 -28.576-11.653 -36.055 LDO 52.25 A ATOM 4811 Cl LPRA 705 -25.749-17.169-35.8341.0050.24 A

AIOM 4812 C2 LPR A 705 -27.2Q6 -17.516 -35.265 1.0049.61 A-

AT.OM 4813 C3 LPRA 705 -27.110 -20.305 -34.460 l.ftQ 50.30 A

ATOM 4814 €4 LPRA 705 -26.562-19.104-33.595 1.0049.76. A

ATOM 4815 C5-LPRA-705 -24.266:-16.6t9-37.841 1.00-4833 A ATOM 4816 C6 LPR A 705 -24.623.-16.538 -39.304 1.004&76 -A

ATOM^* 4817 C7 LPR A 705 -25v942 -L6.777 -39:5071.004937 A

ATOM 4818 C8-LPRA705- -267673-17.062-38:2741.0049.77 A

ATOM 4819 C9 LPR-. A 705 -23.791-15.181-37.4091.0047,68 A

ATOM 4820 ClO LPR A 705 -28.035 -L6.243 -35.305 1.0050.42 A ATOM 4821 CIl LPRA 705 -27.625-15.038-34.7441.0052.11 A

ATOM 4822 C12 LPR A 705 -28.233-13.903-35.5601.0052.03 A

ATOM 4823 C13 LPRA 705 -27.964-12.635-35.1441.0052.74 A

ATOM 4824 C14 LPR A 705 -26.507-19.751-32.272 1.0048.18 A

ATOM 4825 C15 LPRA 705 -25.222-20.397-31.839 1.0047.27 A ^

ATOM 4826 C16 LPRA 705 -25.006-20.961-30.501 1.0047.29 A

ATOM 4827 C17LPRA705 -25.536-20.300-29.293 1.0046.22 A

ATOM 4828 CIS LPR A 705 -25.243-20.857-28.0021.0045.61 A

ATOM 4829 C 19 LPR A 705 -24.410 -2X081 -27.900 LOO 45.21 A ATOM 4830 C20 LPR A 705 -23.882-22.751 -29.1201.0045..60 A

-ATOM 483LC21LPRA7Θ5 -24.185-22.180-30.421 1.0046.04 A

ATOM 4832 Cl GOLA2433 -11.517 -6.452-73.6471.0026.86 A

ATOM 4833 Ol GOLA2433 -10.422 -5.649-73.9691.0029.76 A

ATOM 4834 C2 GOLA2433 -12.404 -6.720-74.8341.0028.22 A ATOM^" 4835 O2 GOLA2433 -13.421 -7.583 -74.471 1.0030.13 A

ATOM 4-836 C3 GOL A2433 -13.142 -5.527 -75.3641.0027.58 A

ATOM 4837 O3 GOLA2433 -13.329 -5.698-76,7481.0024.03 A

ATOM 4838 Cl GOLA2434 -6.284-11.249-54.481 1.0028.59 A

ATOM 4839 Ol GOLA2434 -5.760 -9.994 -54J 63 1.0027,28- A ATOM 4840 C2 GOL A2434 -6.905-ll.915--53.289 T.0029.il A

ATOM 4841 O2 GOLA2434 -7:937-12.759-53.628 1.0032.32 A

ATOM 4842 C3 GOLA2434 -5.955-12.812-52.588 1.0028.71 A

ATOM 4843 O3 GOLA2434 -6.287-12.745-51.232 1.0026,89 A

ATOM 4844ZN+2ZN2B701 -22.955-27.750-91.195 1.0034.77 B ATOM 4845 CL CL B 703 -18.111 -27.426 -36.838 1.0038.31 B-

ATOM' 4846 N^" ALAB 2 -39.505-24.258-120.446 LOO 58T00 B-

ATOM ^"4847 CA ALA B 2 -40.3O0-25.340T-19.815 1.0058.18- B

ATOM 484.8 GB ALAB 2 -4L663 -25.361-120.5961.0057.02 B

ATOM- 4849 C ALA-B-.2 -39.394--26.660-1-2TL142 1.005&50 -B ATOM -4850 O ALAB ^"2 -38.196-26.572-120.131 1.0058.21 B

ATOM 4851 N- PROB 3- -40:016-2.7:878-120.2891.0059:51- B

ATOM 4852 CD PROB 3 -39.131-29.073-120.3891.0059τ85 B

ATOM 4853 GA PROB 3 -41.423 -28.416-12Q.2561.0060.53 B

ATOM 4854 CB PROB 3 -41.194-29.673-119.4501.0060.27 B- ATOM 4855 CG PROB 3 -40.062 -30.302-120.2961.0060.02 B

ATOM 4856 C PROB 3 -42.814-27.876-119.9071.0061.79 B

ATOM 48570 PROB 3 -43.309-26.872-120.4491.0062.07 B

ATOM 4858 N GLYB 4 -43.363-28.557-118.9191.0062.82 B

ATOM 4859 CA GLYB 4 -44.670-28.339-118.321 1.0063.69 B ...

ATOM 4860 C GLYB 4 -44.259-28.112-116.901 1.0064.25 B

ATOM 4861 O GLYB 4 -45.057-27.988-115.9871.0064.32 B

ATOM 4862 N LEUB 5 -42.948-27.916-116.878 1.0064.25 B

ATOM 4863 CALEUB 5 -42.217-27.596-115.668 1.00^63.11 B ATOM 4864 βB LEUB 5 -40.690-27.500-115.912 1.0061.21 B

ATOM 4865 CG LEUB 5 -39.974-25:814-115.942 1.0060.29 B

ATOM 4866 CDlLEUB 5 -38.492-28.578-116.0501.0059.57 B

ATOM 4867 CD2LEUB 5 -40.310-29.507-114.653 1.0060.32 B

ATOM 4868 C LEUB 5 -42^".793 -26.244-115.703 1.0063.43 B ATOM 4869 O LEUB 5 -42.174-25.290-116.015 1.0063.71 B

ATOM 4870N ALAB 6 -44,086-2(5:281-115:6391.0063.62 B

ATOM 48=71 CAALAB 6 -44.776-25,08-5-115.7561.0063.69 B

ATOM 4872 CB ALAB 6 -44.681-24.427-117.1501.0063.64 B

ATOM 4873 C ALAB 6 -46,085-25.036-115.1061.0063.58 B ATOM 4874 O ALAB 6 -46.869-25.99-1-114.9191.0062.77 B

ATOM 4875 N PROB 7 -46.403 -23.808-U4.7101.0064.53 B

ATOM 4876 CD PROB 7 -45.194-23.029-114.3901.0064.82 B

ATOM 4877 CA PROB 7 -47.486-23.556-113.756 1.0065.96 B

ATOM 4878 CB PROB T -46.750-22.960-112.5561.0066.56 B ATOM 4879 CG PRO B 7 -45.581 -22.253-113.157 Ii)O 66.22 B

ATOM 4SSDLC PROJB 7 -48.490-22.548414.304 1.0066.48 B

ATOM 4881 O PRΘB 7 -4878ff6 -21:566-113.6321.0065.75 B

ATOM 4882 N-GLY3 8 -48^981 -22J792-11-5.515 1.0067.03 B"

ATOM -48-83 CA^' GLYB 8 -50:408 -22.778-115.77_6 LOO 67.87 B- ATOM 4884- C GLYB -8 -51.1:63-21.769-114.912 1.0068.52 B

-ATOM -4885 O- GLYB 8 -50.575 -24τ699-l 14:360 1-0068:03 -B

ATOM 4886 N ALAJB 9 -52.471-23.567-114.794 1:006943 B

ATOM 4887 CA ALAB 9 -53.013-22.562-113.888 1.0070.44 B

ATOM 4888 CB ALAB. 9 -53.41-0 -21.312-114..660 1.0070.17 B ATOM 4889 C ALAB 9 -54.203-23.109-113.109 1.0070.95 B

ATOM 4890 O ALAB 9 -55.263-23.369-113.679 1.0072.04 B

ATOM 4891 N PHEB 10 -54.022-23.282-111.804 1.0070.87 B

ATOM 4892 CA PHEB 10 -55.099-23.663-110.941 1.0070.28 B

ATOM 4893 CB PHEB 10 -54.624-24.746-110.035 1.0068.37 B ATOM 4894 CG PHEB 10 -53.225-25.162-110.3381.0066.20 B

ATOM 4895 CDlPHEB 10 -52.263-24.176-110.5791.0065.23 B

ATOM 4896 CD2PHEB 10 -52.852-26.499-110.3821.0065.04 B

ATOM 4897 CElPHEB 10 -50.962-24.478-110.863 1.0064.80 B ATOM -4898 CE2 PHE B 10 -51.529 -2ότ838=l 10.6641.0063.88 B

ATOM 4899 CZ PHEB 10 -50.575 -25.815-110.908- LOO 64.04 B^"

ATOM 4900 C PHEB 10 -55.667-22.523-110.181 1.0071.00 B

ATOM 4901 O PHEB 10 -55.092-21.444-110.015 1.0070.65 B

ATOM 4902 N ALAB 11 -56.846 -22.S49-1-09.721 1:0071.98 B ATOM 4903 CAALAB 11 -57.697-21.934-109.068 1.0073.27 B

ATOM- 4904 CB ALAB 11 -58.954-22.617-108.6-841.0072:65 B

ATOM 4905 C ALAB II -57.348-21.031-107.9561.0074.33 B

ATOM 4906 O ALAB 11 -56.688-21.329-106.929 1.0074.67 B

ATOM 4907 N ALAB 12 -57.887 -19.858-LQ8.193 1.0074.91 B ATOM 4908 CA ALA B 12 -57.820-18:941-107.1311.0075.57- B

ATOM 4909 CB ALAB 12 -58.536-17.639-107.412 LOO 75.09 B

ATOM 4910 C ALAB 12 -58.825-19.877-106.4401.0076.47 B

ATOM 4911 O ALAB 12 -59.707-20.448-107.051 1.0077.15 B

ATOM 4912 N ALAB 13 -58.616 -19.979-105.155 T.0076.65 B ATOM 4913 CA ALAB 13 -59.407-20.688-104.1251.0076.38 B

ATOM 4914 CB ALAB 13 -59.892-22.155-lθ4:.4-62 LOO 75:90 B

ATOM 4915 C. ALAB „13 -58.309 -20.7L6~T03.-1601.0076.53 B

ATOM- 491-6 O ALAJB 13- -57.259 -20.160-103.4271.0076.56 B

ATOM 491-7- N AEAB 14 --58,56-9-21.334-102.035 1.0076:74 -B ATOM 4918 CAALAB 14 -57.563 -2 ^44S-JOl.04-1 LOO 76.83^~ B

A3?©M^~ 4919-CB ALAB 14 -58.166 -21.316-99.638 1.0077.30- =B

ATOM- 4920 C ALA-B^~ 14 -57.041-22:S34-10L313.1.0076.85 B

ATOM 4921 O ALAB 14 -55.842-23.051-101.3301.0077.02 B

ATOM 4922 N ALAB 15 -57.945-23.781-101.5651.0076.62 B ATOM 4923- CA ALAB 15 -57.497-25.152-101.8601.0076.15 B

ATOM 4924 CB ALAB 15 -58.579-26.206-101.4571.0075.90 B

ATOM 4925 C ALAB 15 -57.196-25.232-103.3591.0075.71 B

ATOM 4926 O ALAB 15 -57.082-26.300-103.9631.0075.06 B

ATOM 4927 N GLYB 16 -57.080-24.045-103.9271.0075.38 B ^

ATOM 4928 CA GLYB 16 -56.723-23.906-105.3141.0074.67 B

ATOM 4929 C GLYB 16 -55.234-23.726-105.1281.0074.10 B

ATOM 4930 O GLYB 16 -54.424-24.253-105.881 1.0073.69 B

ATOM 4931 N ALAB 17 -54-881-22.993-104.0721.0073.17 B ATOM 4932 CA ALAB 17 -53-.4T2 -22.769-103.744^" LOO 71.46 B

ATOM 4933 CB ALAB 17 -53.320-21.758-102.590^" 1.0071,37 B

ATOM 4934 C ALAB 17 -52.908-24.108-103.3281.0070.38 B

ATOM 4935 O ALAB 17 -51.725-24.401-103.5221.0070.09 B-

ATQM 4936 N ALAB 18 -53.770-24.935-102.753 1.0069.44 & ATOM 4937 CA ALAB 18 -53.341 -26.253-102.3161.0068J67 B

ATOM 4938 CB ALAB 18 -54:458-26.936-101.5481.0068.12 B

ATOM 4939 C ALAB 18 -52.932 -27.096-103.507 J.0067.65 B

ATOM 4940 O ALAB 18 -51.839-27.660-103.5351.0067.84 B

ATOM 4941 N ALAB 19 -53.813-27.167-104.501 1.0066.29 B ATOM 4942 CA ALA B 19 -53.558-27.949-105.7081.0064.37 B

ATOM 4943 CB ALAB 19 -54.721-27.857-106.6441.0064.73 B

ATOM 4944 C ALAB 19 -52.332-27.354-106.340 l.OQ 62.91 B

ATOM 4945 O ALAB 19 -51.473-28.033-106.908 1.0062.26 B

ATOM 4946 N PHEB 20 -52.252-26.050-106.1971.0060.84 B ATOM 4947 CA PHE B 20 -51.123-25.363-106.7161.0058.64 B

ATOM 4945 CB PHEB 20 -51.261-23.877-106.4061.0058.63- -B

ATOM 4949 CG PHE B 20 -50,021- -23:l29-l<06.6521.0058.85 B

ATOM 4950 CDl PHE-B 20 -50.048 -2 L7J9- 106.9541,0059.18 B~

ATOM 4951- CD2 PHE B 20 -48.800^-23.8 HRO6:6441.0058.13- B ATOM 4952 CE-I-PHE* 2t) -48.869-21.129-107.2371.0058.79 B^~

ATGM 4953 CE2 PHE B 20 -47:636-23.2-02-106.91» 1.0038.40 JB-

ATOM 4954 CZ PHE.B 20 -47:650 -21.860-107:225 1.00^" 59.48 B

ATOM 4955 C -PHEB 20 -49.841 -25.946- tO6.1041.0057.13 B

ATOM 4956 O- PHE B 20 -49.024-26.559-106.793 1.00.56.01 B ATOM 4957 N ALAB 21 -49,669-25.725-104.805 1.0056.00 B

ATOM 4958 CAALAB 21 -48.485-26.200-104.0761.0055.09 B

ATOM 4959 CB ALAB 21 -48.615-25.895-102.5821.0055.72 B

ATOM 4960 C ALAB 21 -48.243-27.685-104.2621.0055.08 B

ATOM 4961 O ALAB 21 -47.102-28.168-104.1961.0053.10 B ATOM 4962 N ALAB 22 -49.332-28.405-104.491 1.0056.47 B

ATOM 4963 CA ALAB 22 -49.274-29.842-104.703 1.0057.59 B

ATOM 4964 CB ALAB 22 -50.698-30.406-104.908 1.0057.02 B

ATOM 4965 C ALAB 22 -48.417-30.083-105.935 1.0058.43 JB ATOM 4966 O ALAB 22 -47.500-30.909-105.915 1.0058.49 B

ATOM 4967 N ALAB 23 -48.719-29.337-106.9961.0058.72 B

ATOM 4968 CA ALA B 23 -47.997-29.431-108.266 1.0058.51 B

ATOM 4969 CB ALAB 23 -48.802-28.735-109.390 1.0059.19 B

ATOM 4970 C ALAB 23 -46.582-28.836-108.185 1.0058.02 B ATOM 4971 O ALAB 23 -45.606-29.498-108.561 1.0057.07 B

ATOM 4972 N ALAB 24 -46.478-27.595-107.696 1.0057.06 B

ATOM 4973 CA ALAB 24 -45.186-26.915-107.571 1.0056.04 B

ATOM 4974 CB ALAB 24 -45.294-25.738-106.615 1.0055.43 B

ATOM 4975 C ALAB 24 -44.133-27.885-107.073 1.0055.85 B ATOM 4976 O ALAB 24 -43.049-27.994-107.635 1.0055.58 B

ATOM 4977 N ASNB 25 -44.471-28.592-106.013 1.0055.97 B

ATOM 4978 CA ASlSTB 25 -43.564 -29.54H05.4471.0057.10 B

ATOM 4979 CB ASNB 25 -44.285-30.274-104,341 1.0058.23 B

ATOM 498Q CG ASNB 25 -43.826-31.655-104.2341.0060.25 B ATOM 4981 ODl ASNB 25 -42.621 -3L926-103.9941.0060.64 B

ATOM 4982 ND2 ASN B 25^" -44.760-32.581-104.461 1.0061.43 B

ATOM 4983^'C ASNB 25 -42.998- -30.543-106.4651.0057.55 B

ATOM 49840 ASNB 25 -41.779-30.722-106.5881.0057.18 B

ATOM 4985 N- ALA B-26 -43.909 -51.176407.202 LQQ.58.74 B ATOM 4986 CA-ALA-B= 26 -43.5_61-32.18θ-108u206 1.0059.15 B

ATQM 4987 CB -ALAB 26 -44.824 -32.772-108.806-L0Q-58.86 B

ATOM 4988 C ALAB 26 -42.-666-31.676-109313 1.0059.32 B

ATOM 49«9 O ALAB 26 -41.784 -32.397-1O9.7901.0059.30 B

ATOM 4990 N SERB 27 -42.891 -30.436-109.724 LOO 59.61 B ATOM 4991 CA SERB 27 -42.080-29.845-110.7671.0060.59 B

ATOM 4992 CB SERB 27 -42.771-28.608-111.296 1.0060.17 B

ATOM 4993 OG SERB 27 -44.142-28.856-111.563 1.0060.23 B

ATOM 4994 C SERB 27 -40.737-29.469-110.151 1.0061.24 B

ATOM 4995 O SERB 27 -39.677-29.736-110.720 1.0061.83 B ^

ATOM 4996 N ALAB 28 -40.805-28.860-108.9691.0061.47 B

ATOM 4997 CA ALAB 28 -39.631-28.416-108.2201.0060.58 B

ATOM 4998 CB ALAB 28 -40.068-27.868-106.872 1.0060.11 B

ATOM 4999 C ALAB 28 -38.587-29.514-108.0141.0059.86 B ATOM 5000 O ALAB 28 -37.397-29.318-108.2471.0059.98 B

ATOM 5001 N GLUB 29 -39.040-30.670-107.5601.0059.00 B

ATOM 5002 CA GLUB 29 -38.132-31.774-107.320 1.0059.07 B

ATOM 5003 CB GLUB 29 -38.942-33.003-106.9261.0060.44 B

ATOM 5004 CG GLUB 29 -33.19S -33.958-106.051 TJ00-62.S7 B ATOM 5005 CD GLUB 29 -39.079-35.082-105.6071.0065.10 B

ATOM 5006 OElGLUB 29 -40.283-34.813-105,508 1.0067.39 B

ATOM- 5007 OE2 GLU B 29 -38.584-36.214-105.3791.0064,80 B

ATOM 5008 C GLUB 29 -37.260-32.084-108.5401.0058.59 B

ATOM.5009 O GLUJB 29 -36.115-32.542-108.4241.00.57.21 B ATOM 5010 N GLNB 30 -37.809-31.813-109.7191.0058.53 B

ATOM 5011 CAGLNB 30 -37.083-32.102-110.951 1.0058.51 B

ATOM 5012 CB GLNB 30 -38.050-32.189-112.148 1.0059.41 B

ATOM 5013 CG GLNB JO -39.173 -33.192-111.9771.0060.95 B

ATOM 5014 CD GLNB 30 -40.032-33.313-113.218 1.0061.34 B ATOM 5015 OElGLNB 30 -39.547-33.681-114.2881.0062.52 B

ATOM 5016 NEIGLNB 30 -4-1.316-33.004-113.0821^".ΘO 61.05 B

ATOM 5017 e GLN:B 30 -36.018 -3U5-1-111.211 1.0057.60 B

ATOM 5018 O GLNB 30 -34.829 -31.366-1 Ll 358-1.00-56.81 B

-ATOM -5019 N V.MJ3-31 -36.457-29.799-111.23S^" 1.0.056.39^' B ATOM 5020 CA VAL B 3.1 -35.570 -28,676Jl 1.4871.ΘG-55.44 B

ATOM 5021 CB VAL B 31 -36.389-27.366-111.6241.0-055.69 B

ATOM 5022 CGl-VALB 31 -37.142 -27.088-11O.351 1.0055.29 B

ATOM 5023 CG2VALB 31 -35.482-26.21-1-111.995 1.0055.55 B

ATOM 5024 C VALB 31 -34.513-28.544-110.393 LOO 54.85 B ATOM 5025 O VALB 31 -33.391-28.115-110.656 1.0054.90 B

ATOM 5026 N LEUB 32 -34.868-28.929-109.171 1.0054.27 B

ATOM 5027 CA LEUB 32 -33.929-28.874-108.0541.0052.35 B

ATOM 5028 CB LEUB 32 -34.685-28.944-106.725 1.0051.87 B

ATOM 5029 CG LEUB 32 -35.454-27.663-106.3871.0051.66 B ATOM 5030 CDlLEUB 32 -36.587-27.981-105.435 1.0052.24 B

ATOM 5031 CD2 LEU B 32 -34.511-26.631-105.7941.0050.62 B

ATOM 5032 C LEUB 32 -32.910-30.014-108.1591.0051.28 B

ATOM 5033 O LEUB 32 -31.707 -2P.785-108.021 1.0051.29 B ATOM 5034 N PHEB 33 -33.378-31.237-108.4041.0049.52 B

ATOM 5035 CAPHEB 33 -32.452-32.355-108,5421.0047.84 B

ATOM 5036 CB PHEB 33 -33.179-33.631-108.9481.0045.45 B

ATOM 5037 CGPHEB 33 -32.257-34.795-109.1581.0044.26 B

ATOM 503 S CDl PHE B 33 -31.805 -35.549-108.0871.004^"4.29 B ATOM 5039 CD2 PHE B _33 -31.803-35.113-110.424 1.0044.50 Ε

ATOM 5040 CEl PHE B 33 -30.908-36.607408.2771.0044.09 B

ATOM 5041 CE-2PHEB 33 -30.907-36.168-110.622 1.00.44.44 B

ATOM 5042 CZ PHEB 33 -30.461-36.914-109.546 1.0043.58 B

ATOM 5043 C PHEB 33 -31.480 -31.979-109J6501.0048.08 B ATOM 5044 O PHEB 33 -30.276 -32.236-109.5681.0048,04 B

ATOM 5045 N ALAB 34 -32.029-31.362-110.691 1.0047.72 B

ATOM 5046 CA ALAB 34 -31.240-30.938-111.835 1.0047.26 B

ATOM 5047 CB ALA B 34 -32.125-30.201-112.8281.0047.58 B

ATOM 5048 C ALAB 34 -30.097-30.037-111.4101.0046.71 B ATOM 5049 O ALAB 34 -28.930-30.302-111.6991.0046.55 B

ATOM 5050 N SERB 35 -30.445-28.970-110.7071.0045.93 B

ATOM 5051 CA SERB 35 -29.461-27:994-1102661.0045.06 B"

ATΘM 5052 CB SERB 35 -30.186-26.780-109.6721.0044.93 B

ATOM tiO53 OG SERB 35 39-374 -25.619- LQ9.711 1:0044.22 B ATOM 5054 C SERB 35 -28.432 ^28.552-109.2771.0044.37 B

ATOM 5055 O SER.B-35 -27.2^"40 -28.266-109.393 LOO-43.95 B

ATOM- 5056 N VALB 36 -28.890 -29.348-1083121.00-43780 B

ATOM 5057 CA VAL B 36 -27.998-29.935-107.3071.0042.97 B

ATOM 5058 CB VAL B 36 -28.795 -30.709-106.2271.0043.80 B ATOM 5059 CGl VAL B 36 -27.831-31.425-105.268 1.0042.39 B

ATOM 5060 CG2VALB 36 -29.714-29.748-105.471 1.0043.35 B

ATOM 5061 C VALB 36 -26.989-30.905-107.9141.0041.91 B

ATOM 5062 O VALB 36 -25.842-30.998-107.4751.0040.15 B

ATOM 5063 N ALAB 37 -27.436-31.641-108.921 1.0041.88 B ^

ATOM 5064 CA ALA B 37 -26.583-32.611-109.5741.0040.79 B

ATOM 5065 CB ALAB 37 -27.438-33.545-110.4201.0040.70 B

ATOM 5066 C ALAB 37 -25.581-31.848-110.433 1.0039.85 B

ATOM 5067 O ALAB 37 -24.426-32.262-110.5971.0037.81 JB ATOM 5068 N ALAB 38 -26.037-30.713-110.9601.0039.58 B

ATOM 5D69 CA ALA-J338 -25.196-29.877-111.8061.0039.94 B

ATOM 5070 CB ALAB 38 -26.018-28.752-112.419 1.0040.04 B

ATOM 5071 C ALAB 38 -24.079-29.313-110.955 1.0039.50 B

ATOM 5072 O ALAB 38 -22.948-29.147-111.4081.0040.21 B ATOM 5073^" N SERB 39 -24.406-29.029-109,704 1.0039.32 B

ATOM -5074 CA SER B ^"39 -23.426-28.492-108.776 1.0037.48 B

ATOM 5075 CBSERB 39 -24.130-27.812-107.6041.0037.91 B

ATOM 5076 OG SERB 39 -25.012-26.800-108.0641.0038.32 B

ATOM 5077 C SERB 39 -22.522-29:608-108.275 1.0036 J2 B ATOM- 5078^" O SERΕ 39 -21.317-29.427-108.163 1.00-35.35 3

ATOM 5079 N TRPB 40 ,23.100-30.771-107.983 1.0036.87 B^~

ATOM 5080 CA TRPB 40 -22.296-31.887-107.4991.0037.39 B

ATOM 5081 CB TRPB 40 -23.159 -33. L34-107.2441.0036.45 B

ATOM 5082 CG TRPB 40 -22.311-34.329-106.836 1.0036.47 B ATOM 5083 CD2TRPB 40 -21.980-34.740-105.4971.0037.04 B

ATOM 50S4 CE2TRPB 40 -21.055 -35J804-105.603 1.0036.57 B

ATOM- 5085 CE3 TRP-B 40 -22.368.-34.308-104.222 LJθO-36.54- B-

AT-OM ,5086 CDl TRP-B-40 -21.600 -35.146-107.664- 1.0035.98 B

ATΘM 5087 NEhTRPB 40 -20:842-36,032-106.93-51.0035.97 B ATOM 5088 CZ2ΕRPB 40 -20.515-36.440-104.4841.0037.23 B

ATOM 5089 CZ3 TRP-B 40- -21.830-34.942=103.1151.0035799 B ATOM-5090 CH2TRPB 40 -20.914-35.994-103.251 1.0036,42 B

ATOM 5091 C TRPB 40- -21.181-32.236-108.4771.0038,87 B

ATOM 5092 O TRP-B 40 -20.073 -32.602-108.075 1.0037.23 B ATOM 5093 N ALAB 41 -21.483-32.120-109.7661.0041.93 B

ATOM 5094 CA ALA B 41 -20.514-32.431-110.8041.0044.43 B

ATOM 5095 CB ALAB 41 -21.171-32.344-112.1571.0044.72 B

ATOM 5096 C ALAB 41 -19.327-31.482-110.7381.0046.71 B

ATOM 5097 O ALAB 41 -18.174-31.904-110.860 1.0047.26 B ATOM 5098 N HISB 42 -19.618-30.198-110.541 1.0048.60 B

ATOM 5099 CA HIS B 42 -18.588-29.161-110.4541.0050.85 B

ATOM 5100 CB HISB 42 -19.246-27.772-110.3821.0052.18 B

ATOM 5101 CG HISB 42 -18.270-26.638-110288 1.0053.82 B ATOM 5102 CD2HIS-B-42- -17.218 -26.299-11T.071 1.0054.04 B

ATOM 5103 NDlHISB 42 -18.340-25.674-109.3041.0054.45 B

ATOM 5104 CElHISB 42 -17.374-24.790-109.4871.0055.13 B

ATOM 5105 NE2 HIS B 42 -16.680-25.146-110.553 1.0055.32 B

ATOM 5106 C HISB 42^" -17.653 -29.33T-109.2491.0051.89 B ATOM 5107 O HISB 42 -16.451-29.555-109.413 1.0051.29 B

ATOM 5108 N ASPB 43 -18.2B- -29.220-108,043^" 1.0053.01 B

ATOM 5 LQ9 CA ASRB 43 -17.446 -29.336- 1O6.80G M)O 53.43 B

ATOM 5110 CB ASPB 43 -18.380-29.343-105.5841.0053.16 B

ATOM 5111 CG ASPB 43 -19.147-28.037-105.403 1.0053.39 B ATOM 5112 ODl ASPB 43 -20.054 -28.010-104.54t) 1.0055.22 B

ATOM 5113 OD2ASPB 43 -18.860-27.035-106.097 LQO 52.15 B

ATOM 5114 C ASPB 43 -16.578 -3O.589-106.738 1.0054.43 B

ATOM 5115 O ASPB 43 -15.486-30.576-106.1571.0054.38 B

ATOM 5116 N THRB 44 -17.075-31.678-107.3191.0055.70 B ATOM 5117 CA THRB 44 -16.358-32.954-107.3041.0057.36 B

ATOM 5118 CB THR3-44- -17.318-34.122-107.6301.0057.03 B

ATOM 5119 OGlTHRB 44- -18359 -34.T72=106,6471.0058.22 B

ATOM 51-20 GG2THRB 44- -16J76 -35.4θ4-107.6J0- 1.00-55.36 B

ATOM 5121 C THR-B 44 45.121-33.031-108.21-1 1.0058=20" B- ATOM -5122 O THRB 44^" -14:226-33.843-107:973 1.0055.23 B

ATOM 5123 N ASN B -45 -15.089-32.212-109.2581.00-58.04 B

ATΘM -5124 CA ASNB 45^" -13L93L8 -32.144-110.1521.0057.68- B

ATOM 5125 CB ASNB 45 -13.818 -33361-111.063 1.0060.07 B

ATOM 5126 CG ASNB 45 -12.840-33.118-112,2101.0061.69 B ATOM 5127 ODl ASNB 45 -11.792-32.479-112.031 1.0062.52 B

ATOM 5128 ND2 ASNB 45 -13.183-33.617-113.395 1.0062.03 B

ATOM 5129 C ASNB 45 -14.043-30.887-110.9871.0056.09 B

ATOM 5130 O ASNB 45 -14.489-30.908-112.133 1.0055.67 B

ATOM 5131 N ELEB 46 -13.609-29.786-110.3901.0054.65 B ATOM 5132 CA ILEB 46 -13.665-28.490-111.040 1.0052.34 B

ATOM 5133 CB ILEB 46 -12.996-27.395-110.171 1.0052.46 B

ATOM 5134 CG2DLEB 46 -13.441-26.001-110.6641.0051.65 B

ATOM 5135 CGlILEB 46 -13.408-27.566-108.709 1.0051.54 B ATOM 5136 CDlILEB 46 -L2.388 -27.029-107.730 LOO 51.48- B

ATOM 5137 C ILEB 46 -12.991-28.451-112.4191.0050.82 B

ATOM 51380 ILEB 46 -11.783-28.643-112.531 1.0050.11 B

ATOM 5139 N THRB 47 -13.787-28.203-113.4591.0049.29 B

ATOM 3140 CA THRB 47 -13.279-28.051-114.825 1.0046.88 B ATOM 5141 CB THRB 47 -13.820-29.123-115.8141.0046.61 B

ATOM 5142 OGl THRB 47 -15.253-29.149-115:7921.0047:11 B

ATOM 5143 CG2 THRB 47 -13255.-30.479-115.492 1.004428 B

ATOM 5144 C THRB 47 -13.804-26.688-115.2241.0045.95 B

ATOM 5145 O THRB 47 -13.952-25.831-114.362 LOO 47.51 B ATOM 5146 N ALA-B 48 -14.075-26.479-116.5071.0043.40 B

ATOM 5147 -CA ALAB 48 -14.626-25.202-116.963 1.0040.92 B

ATOM 5148 CB ALAB 48 -13.708-24,555-117.9941.0039.40 B

ATOM 5149 C ALAB 48 -15.938-25.613-117.595 1.0039.63 B

ATOM 5150 O ALAB 48 -16.859-24.816-117.792 1.0039.14 B ATOM 5151 N GLUB 49 -15.985-26.902-117.908 1.0038.62 B

ATOM 5152 CA GLUB 49 -17.145 -27.541-1-1X5221.0037.1-0 Ε

ATOM 3153 CB GLUB 49 -16.752-28.927-119.0451.0037.28 B

AΪOM 5154 CG-GLUB 49- -16J>00 -29,082-120.53«' LOO 3823 -B

ATOM 5155JCB GLUB 49 -18.347 -29.061-l20_~.976 IrOO 39.83 B ATOM 5156 OElGLUB 4£ -19:090-29.990-120:592-1.00-40.99 B

ATOM 51-57-ΘE2-GLUB-49 -18.744-28.115-121.695 1.0039.64 B

ATOM 5T58^~C GLUB 49 -18τ284 -27.693-117.5341:0035JKL B

ATOM 5159 O GLUB 49 -19.42I -27267-117.7641.00-33.90 B

ATOM 5160 N ASNB 50 -17.954 -28J29- 116.423 1.0033.65 B ATOM 5161 CA ASNB 50 -18.919-28.554-115.376 1.0031.14 B

ATOM 5162 CB ASNB 50 -18.291-29.401-114.291 1.0031.21 B

ATOM 5163 CG ASNB 50 -17.968-30.786-114.7861.0033.67 B

ATOM 5164 ODl ASNB 50 -18.820-31.450-115.3901.0035.78 B

ATOM 5165 ND2 ASNB 50 -16.740-31.237-114.5481.0034.45 B ^

ATOM 5166 C ASNB 50 -19.382-27.224-114.8501.0029.03 B

ATOM 51670 ASNB 50 -20.513-27.091-114.3961.0027.03 B

ATOM 5168 N ALAB 51 -18.512-26.229-114.9681.0028.08 B

ATOM 5169 CA ALAB 51 -18.815 -24.8S2.~114.514 1.0029.02 B ATOM 5170 CB ALAB 51 -17.533-24.045-114.493 1.0028.55 B

ATOM 5171 CALAB 51 -19.863-24.227-115.4091.0030.04 B

ATOM 5172 O ALAB 51 -20.747-23.494-114.9421.0029.38 B

ATOM 5173 N ALAB 52 -19.755-24.497-116.7051.0031.01 B

ATOM 5174 CAALAB 52 -20.688-23.939-117.656 LOO 31.76 B ATOM 5175 CB ALAB 52 -20.133-24.085-119.0571.0032.36 B

ATOM 5176 C ALAB 52 -22.012-24.684-117.5071.0032.58 B

ATOM 5177 O ALAB 52 -23:084-24:103-1-17.6691.0033.26 B

ATOM 5178 N ALAB 53 -21.920-25.973-117.1831.0033.31 B

ATOM 517-9 CAALAB 53 -23.096-26.826-116.9901.0034.16 B ATOM 5180 CB ALAB 53 -22.672-28.282-116.8891.0033.51 B

ATOM 5181 C ALAB 53 -23.838-26.401-115.7241.0036.04 B

ATOM 5182 O ALAB 53 -25.072-26.298-115.723 1.0036.32 B

ATOM 5183 N GLNB 54 -23 J083 -26.160-114.650 LOO 35.96 B

ATOM 5184 CA GLN-B 54 -23.710-25.716-113.431 1.0035.38 B ATOM 5185 CB GLNB 54 -22.661-25.566-112.3091.0036.71 B

ATOM 5186 CG GLN-B 54 -23.224 -25.050-110.9941J9038.31 B

ATOM 5187 CD GLN-B 54 -22.844^" -23.593-110.747^* 1.00^0.22 B

ATOM 5-1-8« ΘE-1 GLNB 54 -21,665-23.222-110.8791.0042-24 B-

ATOM 5189 NE2 GLN-B 54 -23.825 -221758-11G3-93 1700^" 39.69 B AIOM 5190 C GLMS 54 -24377-24.3S9-113.795 1-0035.18 B

ATOM 5191 O- GLNB- 54 -25.595 -24.234"! 13.6481,0035.11 B

ATOM- 5192 N GLUB 55 -237592 -23.454-114.329- 1.0β-34"4i6 B

ATOM 5193 CA GLUB 55 -24.137 -22.140- 114.7091.00-35.09 B

ATOM 5194 GB GLUB 55 -23.D84 -21.285-115.4321.0034.87 B ATOM 5195 CG GLUB 55 -21.967-20.814-114.5101.0036.42 B

ATOM 5196 CD GLUB 55 -21.04749.790-115.1491.0036.00 B

ATOM 5197 OElGLUB 55 -21.569-18.766-115.6471.0035.05 B

ATOM 5198 OE2 GLUB 55 -19.809-20.007-115.1401.0036.11 B

ATOM 5199 C GLUB 55 -25.414-22.190-115.549 1.0035.45 B ^

ATOM 5200 O GLUB 55 -26.218-21.246-115.548 1.0035.37 B

ATOM 5201 N ALAB 56 -25.618-23.297-116.2521.0036.41 B

ATOM 5202 CAALAB 56 -26.810-23.446-117.0691.0036.95 B

ATOM 5203 CB ALAB 56 -26.576-24.504-118.141 1.0037.86 B ATOM 5204 C ALAB 56 -27.954-23.844-146.155 LOO 37.24 B

ATOM 5205 O ALAB 56 -29.012 -23.204- 116.1441.0036.92 B

ATOM 5206 N ALAB 57 -27.725-24.898-115.378 1.0036.90 B

ATOM 5207 CA ALA B 57 -28.721-25.393-114.431 1.0036.88 B

ATOM 5208 CB ALAB 57 -28.121 -26498- 113.5781.0035.78 B ATOM 5209 C ALAB 57 -29.210-24.257-113.541 1.0036.72 B

ATOM 5210 O ALAB 57 -30.383-24.206-113.1571.00.37.04 B

ATOM- 5211 N ALAB 58 -28.293-23.345-113.2361.0035.96 B

ATOM 5212 CA ALAB 58 -28.588-22.205-112.4021.0036.86 B

ATOM 5213 CB ALAB 58 -27.321 -2L448-112.1101.0037.61 B ATOM.5214 C ALA B 58 -29.588-21.309-113.0921.0037.98 B

ATOM 5215 O ALAB 58 -30.546-20.861-112.4781.0037.27 B

ATOM 5216 N LEUB 59 -29.362-21.053-114.3761.0040.19 B

ATOM 5217 CA LEUB 59 -30.265-20.210-115.158 1.0040.62 B

ATOM 521-8 CB LEUB 59 -29:693-19.973-116.561 1.0042.56 B ATOM 5219 CG LEUB 59 -28.837-18.717-116.741 1.0044.15 B

ATOM 5220 CDl LEU B 59 -28.382 -18.579-118.1821.0044.02 B

ATOM 5221 CD2 LEU B 59 -29.669 -17:506-116.343 1.0045.95 B

ATOM 5222 C LEUB 59 -31.612 -20-9B4-115.265^~ 1,0.0-39.76- B

AT-QMi 5223-0 LEUB 59- -32.668^~-20.266-IT5-.308 LOO 39,53 B- AT-OM^" 5224 N LEUB 60- -31.551-22.229-11:5^971. Θ0-3&76- B-

AT©M 5225 CA LEUB .60 -32.736-23.961-115.4091.0038.05 B

ATOM 5226 CB LEU B 60 -32.309 -24.530-115.4901-.00^.5I B

ATOM 5227 CG LEUB 60 -33.125-25.461-116.3891.0039.15 B

ATOM 5228 CDlLEUB 60 -32.363-26,764-116.606 1.0037.76 B ATOM 5229 CD2LEUB 60 -34.484-25.711-115.762 1.0039.08 B

ATOM 5230 C LEUB 60 -33.619-22.835-114.195 1.0037.12 B

ATOM 5231 O LEUB 60 -34.787-22.441-114.312 1.0034.50 B

ATOM 5232 N SERB 61 -33.025-23.077-113.030 1.0036.82 B

ATOM 5233 CA SERB 61 -33.716-22.928-111.7661.0036.17 B ATOM 5234 CB SERB 61 -32.757-23.193-110.6151.0035.48 B

ATOM 5235 OG SERB 61 -32.153-24.468-110.721 1.0034.12 B

ATOM 5236 -C SERB 61 -34.275-21.533-111.6241.0036.62 B

ATOM 52370 SERB 61 -35.407-21.343-111.1891.0035.24 B ATOM 5238 N -GLNB 62 -33.471-20.548-111.992 1.0038.34 B

ATOM 5239 CA GLNB 62 -33.921-19.179-111.8591.0041.35 B

ATOM 5240 CB GLNB 62 -32.807-18.220-112.238 1.0041.12 B

ATOM 5241 CG GLNB 62 -31.437-18.672-111.843 1.0041.13 B

ATOM 5242 CD GLNB 62 -30.404 -17.6U8-112.0661.0042.25 B ATOM 5243 OElGLNB 62 -29.211 -17.888-112.T21 1.0041.88 B

ATOM 5244 NE2 GLN B 62 -30.858 -16366-112.1961.0041.55 B

ATOM 5245 C GLNB 62 -35.151-18.909-112.7101.0044.22 B

ATOM 5246 O GLNB 62 -35.962-18.034-112.418 1.0045.16 B

ATOM 5247 N GLUB 63 -35_^290-19.654-113.788 1.0047.70 B ATOM 5248 CA GLlTB 63 -3i5.453~19.476-l 14.6471.0051.54 B

ATOM 5249 CB GLU B^" 63 -36.273-20.255-115.9291.0053.05 B

ATOM 5250 CG GLUB 63 -35.815-19.475-117.103 1.0054.32 B

ATOM 5251 CD GLUB 63 -35.261-20.415-118.1241.0055.01 B

ATOM 5252 OElGLUB 63 -34.092-20.225-118.5201.0054.58 B ATOM 5253 OE2 GLU B 63 -35.991-21.360-118.4991.0055.17 B

ATOM 5254 C GLUB 63 -37.678-20.024-113.948 1.0052.96 B

ATOM 5255 O- GLUB 6-3 -33.732 -19.388.-113.-839- 1.0052.67 B

ATOM -5256 N PHEB 64 -37.503-21.251-113.495 1.0055.00 B

ATOM^" 5257-CA-PHEB 64- -3SL529 -21.978-112.8041.0056.81- B ATOM 5258 CB PHEB 64 -37.907-23.196-112.150 LQO 57rόO B

ATOM.5259 CGTHEB 64 -38.888=24.072-10.4721.0Q:59.84 R

ATOM 5260- CDl PHEB 64 -39.690-24:925-112.2101.0060.55 B

ATOM 5261 CD2PHEB 64 -38.988 -24.078- U 0.0891.0060.88 B

ATOM 5262 CEl PHE B 64 -40.572-25.782-111.581 1.0061.08 B ATOM 5263 CE2PHEB 64 -39.877-24.933-109.441 1.0061.82 B

ATOM 5264 CZ PHEB 64 -40.668-25.789-110.1871.0061.93 B

ATOM 5265 C PHEB 64 -39.157-21.101-111.752 1.0058.02 B

ATOM 52660 PHEB 64 -40.325-20.739-111.8461.0058.06 B

ATOM 5267 N ALAB 65 -38.351-20.742-110.7601.0059.87 B _erι,

536

ATOM 5268 CA ALA B 65 -38.809 -19.926-109.6441.0061.85 B

ATOM 5269 CB ALAB 65 -37.633-19.543-108.756 1.0061.48 B

ATOM 5270 C ALAB 65 -39.550-18^680-110.074 1.0063.12 B

ATOM 5271 O ALAB 65 -40.3-83 -18.155-109.3271.0063.55 B ATOM 5272 N GLUB 66 -39.256-18.193-111.273 1.00.64.53 B

ATOM 5273 CA GLUB 66 -39.934-16.987-111.710 LOO 65.54 B

ATOM 5274 CB GLUB 66 -39.136-16.230-112.741 1.0064.85 B

ATOM 5275 CG GLUB 66 -39.650-14.828-112.809 1.0065.01 B

ATOM 5276- CD GLUB 66 -40.003-14.414-114.2020.0065.23 B ATOM 5277 OElGLUB 66 -39:169-14.664-115.0990.0065.34 B

ATOM 3278 OE2GLUB 66 -41.102-13.838-114.3920.0065.33 B

ATOM 5279- C GLUB 66 -41.300 -17.254-H2.2741.0066.50 B

ATOM 5280 O GLUB 66 -42.245-16.484-112.0671.0066.39 B

ATOM 5281 N ALAB 67 -41.397-18.352-113.0061.Θ0&L81 B ATOM 528-2 CA ALA B 67 -42.669-18.713-113385 1.0069.04 B

ATOM 5283 CB ALAB 67 -42.549-19.975-114.4041.0069.31^' B

ATOM 5284 C ALAB 67 -43.643-18.916-112.4491.0069,44 B

ATOM 52850 ALAB 67 -44.562-18.118-112.2861.00-69.29 B

ATOM 5286 N TRPB 68 -43.450-19.942-111.625 1.0069.55 B ATOM 5287 CA TRP B 68 -44.432--20.076-110.570 1.0069.61 B

ATOM 5288 CB-TRPB 68 -44.311-21.378-109.767 IDO 68.88 B

ATOM- 5289 CG TRP B -68 -43.757 -22.544-1 H):493 1.0068:64 B

ATOM 5290 CB2TRPB 68 -44.379-23.830-110.7041.0068.80 B

ATOM 5291 CE2-IRP-B..68 -43.410-24.653-111.304 LΘQ£fc43^~ B ATOM^" 5292 CE3TRPB 68 -45.651 -24.369-11074341.0069763 B

ATOM 5293 CDlTRP-B 68 -42J493 -22.650-11ΘΪ976 bθO 68.21 B

ATOM 5294 NEl TRP -B^~ -68 -42.275-23.903-111:4551-0067.93 B

ATOM 5295 CZ2TRPB 68 -43.661 -25.97-7-111.653 1.0068.62 B

ATOM- 5296 CZ3TRPB 68 -45.901-25.710-110.7841.0069.54 B ATOM 5297 CH2 TRP B 68 -44.904-26.489-111.3821.0068.68 B

ATOM 5298 C TRPB 68 -44.366-18.876-109.6301.0069.82 B

ATOM 52990 TRPB 68 -45.398-18.296-109.341 1.0070.46 B

ATOM 5300 N GLYB 69 -43.187-18.474-109.1581.0069.39 B

ATOM 5301 CA GLY B 69 -43.135-17.312-108.2791.0069.46 B _53?

ATOM 5302 C GLYB 69 -44.141-16.248-108.6971.0069.96 B

ATOM 5303 O GLYB 69 -44.962-15.773-107.901 1.0070.21 B

ATOM 5304 N ALAB 70 -44.104-15.887-109.972 1.0070.47 B-

ATOM 5305 CAALAB 70 -45:032-14.885-110.5001.0071.20 B ATOM- 53G6 CB-ALAB 70 -44.657-14.521-111.9441.0070.90 B

ATOM 5307 C ALA B 70 -46.470-15.402-110.4301.0071.41 B

ATOM 5308 O ALAB 70 -47.401-14.647-110.1501.0070.89 B

ATOM 5309 N ALAB 71 -46.639-16.694-110.6921.0071.86 B

ATOM 5310- CA ALAB^" 71 -47.951-17.323-110.631 1.0072.53 B ATOM 5311 CB ALAB 71 -47.858-18.792-111.063 1.0072.76 B

ATOM 5312 C ALAB 71 -48,469-17.220-109.1-991.0073.12 B

ATOM.5313 O ALAB 71 -49.486-16.569-108.9491.0073.30 B

ATOM 5314 N ALAB 72 -47.755-17.856-108.2671.0073.03 B

ATOM 5315 CA ALAB 72 -48.124-17.826-106.852 1.0072.87 B ATOM 5316 CB ALAB 72 -46.928-18.191-105.996 1.0072.93 B

ATOM 5317 C ALAB 72 -48.574-16.412-106.536 1.0072.80 B

ATOM 5318 O ALAB 72 -49.655-16.197-105.9841.0073.37 B

ATOM 5319 N ALAB 73 -47.737-15.452-106.921 1.0072.62 B

ATOM 5320 CA ALAB 73 -48.062 -14.063-106.695 LOO 72.67 B ATOM 5321 CB ALAB 73 -46.968-13.143-107.1771.0072.56 B

ATOM 5322 C ALA-B ^"73 -49.323-13.694-107.383 1.0072.46 B

ATOM 5323 O ALAB 73 -50.277-13.299-106.7771.0072.39 J3

ATOM -5324- N ALAB 74 -49.428-13.835-108.675 1.0072.39- B

ATOM- 5325 CA ALA B 74 -50.696-13.271-108:95.41.00-72.72 B^" ATOM 5326 CB-ALAB 74 =50.626-12.230-110.073 1.0071.45 B

ATΘM 532TC ALAB 74 -51.958 -14.053-108τ915 Ϊτθθ-73u24 B

ATOM 532S-O -ALAB 74 -53.025 -13.567-109:3 Ϊ91.0073.45 -B

ATOM 5329 N LEUB 75 -51.870-15.281-108.555 1.0073.23 B

ATOM 5330 CA LEUB 75 -53J38 -15.872-108.4141.0073.41 B ATOM 5331 CB LEUB 75 -53.002-17.401-108.261 1.0073.14. B

ATOM 5332 CG LEUB 75 -53.317-18.257-109.461 1.0072.70 B

ATOM 5333 CDlLEUB 75 -52.623-17.645-110.6581.0073.67 B

ATOM 5334 CD2 LEU B 75 -52.799-19.679-109.195 1.0071.88 B

ATOM 5335 C LEUB 75 -53.443-15.339-106.986 1.0074.14 B „_

JJO

ATOM 5336 O LEUB 75 -54.497-14.788-106.641 1.0074.87 B

ATOM 5337 N TYRB 76 -52.379-15.500-106.1971.0074.16 B

ATOM 5338 CA TYRB 76 -52.307-15.373-104.7481.0073.62 B

ATOM 5339 CB TYRB 76 -51.818-16.737-1-04.351 1.0072:04 B ATOM 5340 CG TYRB 76 -52.558-17:898-104.993 1.0071.18 B

ATOM 5341 CDlTYRB 76 -51.927 -19.143-105.1311.0(T7&97 ^"B

ATOM 5342 CElTYRB 76 -52.636-20.283-105.4791.0070.98 B

ATOM 5343 CD2 TYRB 76 -53.941 -17.821-105.2541.0071.19 B

ATOM 5344 CE2TYRB 76 -54.65S:-i-8.953-lθ5.6051.0071.52 B ATOM 5345 CZ TYRB 76 -54.000-20.179-10577061.0071.42 B

ATOM 5346 OH TYRB- 76 -54:694 -21.319=R)6.010 1-.0Θ-7131 B

ATOM 5347 -C TYRJB 76 -51653 -14.426-103.741 1.0074.23 -B

ATOM 5348 O TYRB 76 -51.247-14.910-102.669 1.0073.57 B

ATOM 5349 N GLUB 77 -51.553-1-3.137-103.991 1.0075.62 B ATOM 5350 CA GLUB 77 -50.932-12.263-10370121.0077.67 B

ATOM 5351 CB GLUB 77 -49.723-11.592-103.611 1.0Θ 77.95 B

ATOM 5352 CG GLUB 77 -49.401-10.28-1-102.991 1.0079.61 B

ATOM 5353 CD GLUB 77 -47.947-10.025-102.831 1.0080.46 B

ATOM 5354 OElGLUB 77 -47.248 -9.789-103.8401.0081.62 B ATOM 5355 OE2GLUB 77 -47.526-10.044-101.6641.0081.10 B

ATOM 5356 -G GLUB 77 -51.9.62 -Ll.378-102.263^~ 1.-00-78.60 B-

ATOM 5357 O GLUB- 77 -51.636-10.493-101.511 r.00^~79JL2 B

ATΘM 5358 N PROB -78- -53.25S--14.507-l:02.6071.0078.96_ B

ATOM 5359 ^"CD PROB 78. -53.082-10:768-103.874 h0078.65 B ATOM 5369 CA ERO B 78 -547432^~10,SS2-102.0θ3 1.00r78.91 B

ATOM 5361- CB PRO-B 78 -55.292 -10=531-103.218. LOG 7876Θ B

ATOM 5362 CG PRO B 78 -54v378--9.785JjQ3.9691.0078,21 B

ATOM 5363 C PROB 78 -54.856 -12. B6-101.2T61.0079.10 B

ATOM 5364 O PROB 78 -55.377-13.090-101.7891.0018,20 B ATOM 5365 N ALAB 79 -54.461-12.126-99.9321.0080.10 B

ATOM 5366 CA ALA B 79 -54.687-13.146-98.8821.0081.43 B

ATOM 5367 CB ALAB 79 -56.216-13.392-98.641 1.0081.39 B

ATOM 5368 C ALAB 79 -53.976-14.485-98.9801.0082.31 B

ATOM 5369 O ALAB 79 -54.595-15.553-99.111 1.0082.95 B ATOM 5370 N TRPB 80 -52.658-14.424-98.929 1.0082.83 B

ATOM 5371 CA TRPB 80 -51.898-15.649-98.944 1.0083.17 B

ATOM 5372 CB TRPB 80 -50.798-15.596-99.992 1.0083.13 B

ATOM 5373 CGTRPB 80 -49.773-14.603-99.709 1.0082.74 B ATOM 5374 CD2 TRP B 80 -48.556-14.855 -99:035 1.0082.20- B^"

ATOM 5375 CE2 TRP B 80 -47.822-13.651-99:033 1.00-81.90 B

ATOM 5376 CE3 TRP B 80 -48.011-15.993-98.4241.0081.97 B

ATOM 5377 CDlTRPB 80 -49.756-13.290-100.083 1.0082.41 B

ATOM 5378 NEl TRP B 80 -48.578-12.708-99.682 1.0081.69 B ATOM 5379 CZ2 TRP B 80 -46.560-13.552-98.449 LOQ 81.84 B

ATOM 5380 CZ3TRPB 8B -46.767-15.901-97.840 1.0081:85 B

ATOM 5381 CH2 TRP B- 80 -46.048 -14.684 -97J8541.00.82.20 B

ATOM 5382 C TRPB 80 -51.355-15.729-97.522 1.0083.23 B

ATOM 5383 O TRPB 80 -50.916-16.785-97.061 1.0083.47 B ATOM 5384 N ALAB 81 -5L437 -14.597 -96.821 1.0082.82 B

ATOM 5385 CA ALAB 81 -51.011-14.511-95.429 1.0081.90 B

ATOM 5386 CB ALAB 81 -50.815-13.039-95.026 1.0081.36 B

ATOM 5387 C ALAB 81 -52.160-15.109-94.636 1.0081.08 B

ATOM 5388 O ALAB 81 -51.969-15.799-93.633 1.0080.62 B ATOM 5389 N ASNB 82 -53.360-14.836-95.141 1.0080.05 B

ATOM 5390 CAASNB 82 -54.625-15,264-94.5451.00-7832 B

ATOM 5391 CB ASN-B 82 -55.653 -14.1-32 -94.6841.0078.21 B.

ATOM -5592-GGASNB 82- -55.475 -13.050 -9-fc6321.0D7T.9β B

ATOM 5393 OD1ASNBU82 -55=426-137338-92.4371.007-7.92 B ATOM.5394-ND2ASNB 82 -55.387-11.801 -94.069 LOO 78:08^"- B-

ATOM 5395 C ASN-B- 32- -55.295 --1&583 -94.9741. OO 7-7.81 B

ATOM 5396 O ASNB 82 -56.473 -16.^"590--95τ3201.0077.35 B

ATOM 539-7 N ALAB 83 -54.568 -17.696 -.94.9071.0077.46 B

ATOM 539S CA ALA B- 83 -55.117-19.008-95.263 1.0077.49 B ATOM 5399 CB ALAB 83 -54.013-19.840-95.8871.0077.71 B

ATOM 5400 C ALAB 83 -55.652-19.657-93.9771.0077.61 B

ATOM 5401 O ALAB 83 -55.978-18.962-93.0261.0077.87 B

ATOM 5402 N ALAB 84 -55.797-20.976-93.9721.0077.53 B

ATOM 5403 CA ALA B 84 -56.217-21.707-92.7801.0077.46 B _54Q

ATOM 5404 CB ALAB 84 -57.526-22.417-92.9161.0077.04 B

ATOM 5405 C ALAB 84 -55.029 -22.634 -92.8091.0077.56 B

ATOM 5406 O ALAB 84 -54.754-23.367-91.8791.0078.21 B

ATOM 5407 N ASPB 85 -54.283-22.576-93.906 LOO 77.32 B ATOM 5408 CA ASPB 85 -52.861-22.901-93.872 1.0077.31 B

ATOM 5409 CB ASPB 83 -52.463-23.715-95.1041.0077.90 B

ATOM 5410 CGASPB 85 -52.727-25.198-94.9321.0077.93 B

ATOM 5411 ODlASPB 85 -51.807-25.920-94.4941.0078.54 B

ATOM 5412 OD2ASPB 85 -53.824-25.729-95.2051.0077.36 B ATOM 5413 C ASPB 85 -51.994-21.651-93.7571.0077.12 B

ATOM 5414 O ASPB 85 -52. T85 -20.682 -94.493 1.0677.49 B

ATOM -5415 N PROB 86 -51.044-21.679-92.8291.0076.63 B

ATOM 5416 CDPROB 86 -50.774-20.428-92.0981.0076.03 B

ATOM 5417 CA PRO-B 86 -49.836 -22.497 -92.9851.0075.74 B ATOM 5418 CB PROB 86 -48.747 -21.646-92.3201.0076Λ 6 B

ATOM 5419 CG PRO B 86 -49.301-20.264-92.2951.0075.97 B

ATOM 5420 C PRO a 86 -49:964-23.836-92.2671.0074.65 B

ATOM 5421 O PROB 86 -50.654-23.926-91.2521.0073.94 B

ATOM 5422 N GLNB 87 -49.302-24.861-92.7921.0073.53 B ATOM 5423 CA GLN B 87 -48.016 -24.685 -93.455 1.0072.92 B

ATOM 5424 CB GLN-B 87 -47JO43 -25.791 -93.03S 1.0071.62 B-

ATOM 5425 CG-GLNB 87 -47.308-27.133 -93,701- L(K) 70.71 B

ATΘM 5426 CD GLN-B -87 -47.462 --28.258-92.6971.0071.08- B

ATOM 5427 ©El GLNB &7 -48.384-28.246 -91.SSl- 1.007kθ6 ^"B- ATOM 5428. NE2 -SLN B 87 -4:6.562 -29-232.-92:753- 1.0070.82 B

ATOM 5429 C GLNB «7 -48X76-24.672-94:933-1700-73.51- B

ATOM 5430 O GLNB 87 -47.222 -24.919-9577U8 LOO 73.83 B

ATOM 5431 N- ALAB 88 -49.390 -24,3^"83 -95.429 -LQO 73.81 B

ATOM 5432 CAALAB 88 -49.602-23.913-96.793 1.0073.11 B ATOM 5433 CB ALAB 88 -51.079 -23,972 -97.L51 1.0073.26 B

ATOM 5434 C ALAB 88 -49.064-22.498-96.9791.0072.58 B

ATOM 5435 O ALAB 88 -48.307-22.230-97.912 1.0073.26 B

ATOM 5436 N ALAB 89 -49.459-21.597-96.0861.0071.89 B

ATOM 5437 CA ALAB 89 -48.989-20.218-96.131 1.0071.40 B ATOM 5438 CB ALA B 89 -49.463 -19.436 -94.9291.0070.74 B

ATOM 5439 C ALAB 89 -47.470-20.221-96.1581.0071.22 B

ATOM 5440 O ALAB 89 -46.854-19.481-96.9261.0071.28 B

ATOM 5441 N ALAB 90 -46.870-21.068-95.325 1.0071.18 B ATOM 5442.CA ALAB 90 -45.40ft-21.172 -95.255 1.ΘQ 71.20 B

ATOM 5443 CB ALAB 90 -45.000-22.304-94.29O 1.0071.09 B

ATOM 5444 C ALAB 90 -44.769-21.413-96.631 1.0070.34 B

ATOM 5445 O ALAB 90 -43.688-20.886-96.9361.0070.73 B

ATOM 5446 N ELEB 91 -45.446-22.205-97.4571.0068.46 B ATOM 5447 CA ILE B 91 -44.949-22.527-98.785 1.0066.17 B

ATOM 5448 CB ILEB 91 -45.710-23.709-99.3761.0065.13 B

ATOM 5449 CG2ILEB 9L -44.894 -24.328-H)0.493 1.0064.76 B

ATOM 5450 CGlILEB 91 -45.992-24.732-98.2751.0065.30 B

ATOM 5451 CDl ILE B 91 -45.463 -26.140-98.559 LOO 64.51 B ATOM 5452 C JLE B- 91 -45.056-21.368.-99.772 LOO 65.30 B

ATOM 5453 O ILEB 91 -44.068-20:954-100.3761.0065.15 B

ATOM 545-4 N ILE B 92 -46.267 -20.859 -99.9451.0063.90 B

ATOM 54-55 CA ILEB 92 -46.518-19.770-100.8821.0063.48 B

ATOM 5456 CB DLEB 92 -48.040-19.421-100.903 1.0062.90 B ATOM 5457 CG2 ILE B 92 -48.707-19.934-99.651 1.0063.27 B

ATOM 5458 CGl ILE B 92 -48.260 -17.920-101 J081.0061.72 B

ATOM- 5459 CBIrϊLEB 92. -49-.I36-Ϊ7.629-102.2671.00.60.21 B

ATOM 5460 C JDLEB 92 -45.659 -18.515- 1.00,6721.0063.41 Bi

ATOM 5461--O_τILEΕ 92 -45.370 -17.777- 10 Iτ6171.0064.04- B ATOM 5462 N GLY.B 93 -45.237-18,278-99.439 h00 o3J)5 B-

ATOM- 5463 €A GLYB 93 -44.383 -1X135 -99.195- 1.0061.-95 B

ATOM 5464 C GLYB 93 -43.003 -17.563 -99.631 1.0061.58 B

ATOM 5465 O GLYB 93 -42.218-16=736-100.061 1.0060.97 -B

ATOM 5466 N ALAB 94 -42.712-18.862-99.518 1.0061.24 B ATOM 5467 CA ALA B 94 -41.398-19.397-99.908 1.0061.13 B

ATOM 5468 CB ALAB 94 -41.129-20.718-99.1941.0061.12 B

ATOM 5469 C ALAB 94 -41.265-19.610-101.4201.0061.37 B

ATOM 5470 O ALAB 94 -40.171-19.871-101.9481.0061.84 B

ATOM 5471 N VALB 95 -42.391-19.496-102.113 1.0060.15 B ATOM 5472 CA VAL B 95 -42.426-19.696-103.546 1.0058.05 B

ATOM 5473 CB VALB 95 -43.616-20.625-103.9161.0057.51 B

ATOM 5474 CGl VAL B- 95 -44.346-20.112-105.137 1.0056.64 B

ATOM 5475 CG2VALB 95 -43.099-22.048-104.1661.0056.40 B ATOM 5476 C VALB 95 -42.500-183-73-104.300 1.0057.08 B

ATOM- 5477 O VALB 95 -42.124 -1S.298-1O5.468 1.0056.90 B

ATOM 5478 N ARGB 96 -42.962-17.321-103.6391.0055.90 B

ATOM 5479 CA ARG B 96 -43.053-16.022-104.294 1.0056.33 B

ATOM 5480 CB ARGB 96 -44.323-15.279-103.868 1.0056.81 B ATOM 5481 CG ARGB 96 -44.460-15.021-102.366 1.0057.61 B

ATOM 5482 CDARG-B 96 -45.144-13:681-102.090 1.0057.45 B

ATOM 5483- NE ARG B- 96 -44.167-12.603-101.913 1.0057.83 B

ATOM 5484 CZ ARGB 96 -44.494-11.331-101.7001.0058.52 B

ATOM 5485 NHl ARGB 96 -43.56440.393-101.539 1.0057.78 B ATOM 5486 NH2 ARG B- 96 -45.765 -10.997-101.6541.0058.77 B

ATOM 5487 C ARGB 96 -41.824-15.219-103.900 1.0056.59 B

ATOM 5488 O ARGB 96 -41.807-13.989-103.931 1.0055.69 B

ATOM 54S9 N THRB 97 -40.796-15.936-103.4871.0057.06 B

ATOM 5490 CA THRB 97 -39.568-15.281-103.105 1.0057.01 B ATOM 5491 CB THRB 97 -39.200-15.682-101.6621.0056.85 B

ATOM 5492 OGlTHRB 97 -39,125-14.499-100.8571.0055.37 B

ATOM 5493 CG2THR-B 97 -37.887-16.454-101.5971.0055.98 B

ATOM 5494 C THRB 97 -38.593-15.773-104.1571.0057.35 B

ATBM .5.495 O THRB-97 -37.9L0-16.784J 04.0041.0057.52 B ATOM 5496 N LEUB 98 -387579-15.044-105,263 1.0057.18 B_

ATOM 5497^"CA_bEUB 98 -37.769-15.409-106.4191.-0056.31 B^"

ATOM- -5498 CB LEU B- 98 -38.103 -14τ476- 107.590" 1:0056.49 B

ATOM 5499 CGLEUB 98 -39.559-14.018-107.7561.00-56.32 B-

ATOM 5500 CDlLEUB 98 -39.689-13.215-109.0400.0056.56 B ATOM 5501 CD2LEUB 98 -40.500-15.222-107.7880.0056.48 B

ATOM 5502 C LEUB 98 -36.263-15.444-106.2021.0055.12 B

ATOM 5503 O LEUB 98 -35.565-16.302-106.7481.0054.10 B

ATOM 5504 N GLYB 99 -35.756-14.519-105.4041.0054.64 B

ATOM 5505 CA GLYB 99 -34.328-14.502-105.171 1.0054.55 B ATOM 5506 C GLY B 99 -33.602 -13.916-106.365 1.00 54.21 B

ATOM 5507 O GLY B 99 -33.995 -12.862-106.879 1.00 53.90 B

ATOM 5508 N SERB lOO -32.551 -14.590-106.824 1.00 53.15 B

ATOM 5509 CA SERB 100 -31.784 -14.074-107.952 1.00 52.87 B ATOM 5510 CB SERB 100 -30.474 -14.858-108.121 KOO 52.10 B

ATOM- 5511 OG SER B lOO -30.698 -16.245-108.275 1.00 52.11 B

ATOM 5512 C SER B lOO -32.576 -14.086-109.259 1.00 53.42 B

ATOM 5513 O SER B lOO -32.145 -13.520-110^265 1.00 53.38 B

ATOM- -55T4 N ALA B 101 -33.746 -14.714-109.236 1.00 53.42 B ATOM 5515 CA ALA B lOl -34.597 -14,803-110;419 1.00 52.47 B

ATOM 5516- GB ALAB-IOl- -357711 -15.796-1 IGd 77 1.0052.98 B

ATOM 5517 C ALA£-101 -35.197 -13.458-110:811 1.00 51,85 B

ATOM 5518 O ALA B 101 -35.754 -13.311-111.889 1.00 51.58 B

ATOM 5519 N ASN B 102 -35.116 -12.488-109.917 lJOO 51.53 -B ATOM 552Q -CA ASN B 102 -35.651 -11.170-110.213 1.00 52.14 B

ATOM 5521 CB ASN B 102 -35.832 -10.394-108.938 1.00 53.02 B

ATOM 5522 CG ASN B 102 -36.945 -10.921-108.138 1.00 54.19 B

ATOM 5523 ODl ASNB 102 -37.882 -10.196-107.810 1.00 54.92 B

ATOM 5524 ND2 ASN B 102 -36.884 -12.210-107.832 1.00 54.87 B ATOM 5525 C ASNB. 102 -34.745 -10.390-11L118 1.00 52.15 B

ATOM- 5526 O ASN B 102 -35.079 -9.300-111.600 1.00 5L83 Ε

ATOM 552T N LEUB 103 -33.584 -10.976-11O3.9 1.00 51.66 B

ATOM 5528- CA LEU-B 103 -32.561 -10.380-11-2.162 1.00 50.92 B

^"ATOM 5529 CB-LEUB 103 -31.197 -10.872-111.706^" LO0 51.83 -B ^"ATOM 5530 CG LEU B 103 -30.616 -10.468-110.361 1.00 51.48 B

ATOM 5531 CBl BEU-B 103 -29.387 -lT.33:ό--l 10.113 1.00-50.77 B

AIQM 5532 CD2 LEU B 103 -30270 -8.982-110^63 1.00 49:84 B

ATOM 5533 C LEU-B 103 -32.728 -10.738-1 B.618 1,0049.49 B

ATOM 5534 O LEU B 103 -33.022 -11.890-1-13.958 1.0049.67 B ATOM 5535 N PRO B 104 -32.518 -9.754-114.505 1.0048.02 B

ATOM 5536 CD PRO B 104 -32.271 -8.334-114.200 1.00 47.68 B

ATOM 5537 CA PRO B 104 -32.636 -9.963-115.952 1.0046.63 B

ATOM 5538 CB PRO B 104 -32.272 -8.602-116.530 1.0045.81 B

ATOM 5539 CG PRO B 104 -32.722 -7.658-115.486 1.00 46.58 B ATOM 5540 C PRO B 104 -31.681 -11.055-116.430 1.00 45.60 B

ATOM 5541 0 PRO B 104 -30.687 -11.347-115.770 1.00 45.80 B

ATOM 5542 N ALA B 105 -31.983 -11.644-117.583 1.0044.64 B

ATOM 5543 CA ALA B 105 -31.158 -12.716-118.147 1.0043.45 B ATOM 5544 CB- ALA-BI 05, -31.514 -12.941-119.627 1.0044.41 B

ATGM- 5545 C ALA B 105 -29,667 -12.442-1.1-8.021 1.00 41.53^" B

ATOM 5546 0 ALA B 105 -28.910 -13.248-117.475 1.0040.13 B

ATOM 5547 N ALA B 106 -29.253 -11.291-118.533 1.00 39.31 B

ATOM 5548 CA ALA B- 106 ~27.852^"~-l 0.909-118.506 1.00 37.58 B ATOM 5549 CB ALA B 106 -277680 -9.578-119.201 1.00 38.06 B

ATOM 5550 C ALA B 106 -27.251 -10:844-117.112 1.00 36.08 B

ATOM 5551 O ALA B 106 -26.145 -11.336-116^-80 1.00 35.05 B

ATOM 5552 N LYS B 107 -27.961 -10.207-116.187 1.00 34.34 B

ATOM 5553 CA LYS B 107 -27.444 -10.113-114.831 1.00 33.14 B ATOM 5554 CB- LYS B 1-07- -28258 -9.14T-114.021 1.00 30.54 B

ATOM 5555 CG LYS B 107 -27.650 -7.786-114.058 1.0029.17 B

ATOM 5556 CD LYS B 107 -28V713 -6.770-113.898 1.00 27.16 -B

ATOM 5557 CE LYS B 107 -28.140 -5.478-113.428 1.0026.78 B

ATOM 5558 NZ LYS B 107 -29.240- -4.635-112.898 1.0028.81 B ATOM 5559 C LYS B 107 -27.399 -11.445-114.131 1.00 33.85. B

ATOM 5560 O EYS R107 -26,48O -11.735-113.368 1.00 34.12. B

ATOM 5561 N ARGB lOST -28.396-12.267-114.404 L00-34.44 B

ATOM 5-562 CA ARG-B- 108 -28.436 -13.572--113.795 1.0035.91 B

ATOM 5563 CB-ARGBrIOS -29.583 -14.418-114.334 1-.00.36.9-4 B - ATOM 5564 CG ARG-B-IOS -30.972 -13:990-J 13,919 1.0038.39 B

ATOM 5565^~CD ARGB 108 -31.985 -14τ9-99414.442 1.0038.44 B

A-TOM 5566 NE ARG B 108 -33.356 -14.538-114.280 1.00 39:54 B

ATOM 5567 CZ ARG B 1G8 -34.418 -15.188-114.741 1.00 41.13 B

ATOM 55.68 NHl ARG B 108 -34.270 -1-6.335-115.398 1.0041.51 B ATOM 5569 NH2 ARG B 108 -35.632 -14.691-114.545 1.0042.42 B

ATOM 5570 C ARG B 108 -27.160 -14.291-114.116 1.00 35.70 B

ATOM 5571 O ARGB 108 -26.551 -14.896-113.247 1.00 37.52 B

ATOM 5572 N GLN B 109 -26.741 -14.243-115.371 1.00 35.72 B

ATOM 5573 CA GLN B 109 -25.522 -14.967-115.684 1.00 35.29 B ATOM 5574 CB GLNB 109 -25.345-15.191-117.2081.0035.69 B

ATOM 5575 CG GLN B 109 -26.329-14.495-118.1441.0036.78 B

ATOM 5576 CD GLN B 109 -26.181-14.951-119.6181.0038.59 B

ATOM 5577 OEl GLNB 109 -27.127-14.834-120.4161.0038.13 B ATOM 5578 NE2 GLN B 109 -25.001-15.472-119.975 1.00=37.28 B

ATOM 5579 C GLNB 109 -24:279-14,334-115.061 1.003^15 B

ATOM 5580 O GLNB 109 -23.287-15.026-114.8381.0033.35 B

ATOM 5581 N GLNBIlO -24.332-13.037-114.7631.0032.74 B

ATOM 5582 CA GLNBIlO -23.193 -12.394-114.129 l.OΘ 32.34^" B ATOM 5583 CB GLNBIlO -23.383 -10.876-114.074 1.003T.44 B

ATOM 5584- CG GLNBIlO -23.296 -10.172-115.403 1:GD 31.21 B

ATOM 5585 CD GLNBIlO -23.454 -&672- 1.15.2761.0030.80 B-

ATOM 5586 OEl GLNB 110 -22.681 -8.010-114.5891.0031.94 B

ATOM 5587 NE2 GLNB 110 -24.460 -8.127-115.9421.0030.76 -B ATOM 5588 C GLNB 110 -23.197-12.977-112.7201.0033:81 B-

ATOM 5589 O GLNBIlO -22.178-13.453-112.2041.0033.41 B

ATOM 5590 N TYRBlIl -24.378-12.957-112.112 1.0034.37 B

ATOM 5591 CA TYRBlIl -24.544-13.489-110.776 1.0Q 34.36 B

ATOM 5592 CB TYRB 111 -26.023-13.494-110.3801.0035:20 B ATOM 5593 CG TYRBlIl -26.245-13.858-108.9291.0036.66 B

ATOM 5594 CDl TYRB 111 -25.839 -13,091-107.917 LOO 37731 B

ATOM- 5595 CEl TYRB 111 -25,995 -13.344-106^579 kθθ 37.94- B^*

ATOM 5596-CD2 TYRJB-111 -26.822 -L5.079-19&5671:0.037.-16 B

ATOM 55ff7 CE2-TYR BTIl -26.982-15^32-1072321.0037.49 B ATΘM- 5598 CZ TYR-BlIl -26.564-14.561-106:243 1:00-37.22 B

ATOM- 5599-OH TYR Bill -26,706 -14τ908-104.91-91.0036.73 B

ATOM^" 5600 C TYRBlIT -23.999-14.911-1-10:747 LCKL33.84 B

ATOM 5601 O TYRBlIl -22.971^" -15.177-110.1281.0033T22 B

ATOM 5.602 N ASNB 112 -24.684 -15:813-111.4461.0033.66 B ATOM 5603 CA ASNB 112 -24.293-17.221-111.486 1.0034.28 B

ATOM 5604 CB ASNB 112 -25.107-18.003-112.528 1.0036.20 B

ATOM 5605- CG ASNB 112 -26.603-17.852-1123491.0038.93 B

ATOM 5606 ODl ASNB 112 -27.089-17.702-111.2321.0042.82 B

ATOM 5607 ND2 ASN B 112 -27.345-17.909-113.453 1.0039.87 B ^

ATOM 5608 C ASNB 112 -22.823-17.408-111.7991.0034.16 B

ATOM 5609 O ASNB 112 -22.222-18.404-111.4081.0033.78 B

ATOM 5610 N ALAB 113 -22.240-16.455-112.518 1.0034.73 B

ATOM 5611 CA ALAB 113 -20.832 -16.572-112.8S61.0034.04 B ATOM 5612 CB ALAB H3 -20.546 -15.812-114.1821.0033J7 B

ATOM 5613 C ALAB 113 -19.950-16.057-111.7661.0033.16 B

ATOM 56140 ALAB 113 -18.887-16.629-111.491 1.0033.08 B

ATOM 5615 N LEUB 114 -20.386-14.976-111.121 1.0031.09 B

ATOM 5616 CA LEUB 114 -19.617 -14.431-H0.014 1.O028.65 B ATOM 5617 CB LEUB 114 -20.284-13.176-109.468 1.0025.81 B

ATOM 5618 CG LEUB 114 -19.967-11.899-110.235 1.0024.27 B

ATOM 5619 CDl LEUB 114 -20.703 -10.716-109.628 1.ΘQ_23.O5 B

ATOM 5620 CD2 LEU B 114 -18.471-11.669-110.198 1.0023.87 B

ATOM 5621 C LEUB 114 -19.502-15.492-108.9171.0028.76 B ATOM 56220 LEUB 114 -18.462-15.631-108.2771.0028.49 B

ATOM 5623 N LEUB 115 -20.566-16.261-108.7221.0027.47 B

ATOM 5624 CA LEUB 115 -20.549-17.293-107.711 1.0027.81 B

ATOM 5625 CB LEUB 115 -21.933-17.905-107.573 1.0027.22 B

ATOM 5626 CG LEUB 115 -22.962-16.914-107.0181.0029.04 B ATOM 5627 CDl LEUB 115 -24.359-17.507-107.094 1.0027.14 B

ATOM 5628 CD2XEUB115 -22.607-16.546-105.571 1.0030.30 B-

ATOM 5629 C LEUB 115 -T9τ529 -18.375-1083)331-.00J29.00 B

ATOM- 5630- O LEUB 115 -18.689 -18.716-107 J95 IJM 30:95 B

ATOM 5.631 N SERB 116 -19.597 -18.9Θ4-£Q9.2541.0028.85 B - ATΘM 5632 CAUSER B-11.6- -=18.685 -19.975-109v6741:0028.96 B

ATOM 5633 CB SERB 116 -1-9:078-20.505-11 L063 1.0031.67 B

ATOM 5634 OG SER-B- 116^" -173*55 -21.118-1-11.678 1.00-33.07^" -B

ATOM 5635 C SER B- 116 -17.222-19.607-109.6891.0027.86 B

ATOM 5636 O SERB 116 -16343-20.407-109.383 1.0026.99 B ATOM 5637 N ASNB 117 -16.-969-18.380-110.0641.0027.49 B

ATOM 5638 CA ASNB 117 -15.629-17.889-110.1391.0027.40 B

ATOM 5639 CB ASNB 117 -15.734-16.653-110.9261.0030.47 B

ATOM 5640 CG ASNB 117 -15.570-16.968-112.2901.0034.60 B

ATOM 5641 ODlASNB 117 -14.444-17.044-112.711 1.0037.62 B _54?

ATOM 5642 ND2 ASNB 117 -16.650 -17.303-113.006 1.00 37.21 B

ATOM 5643 C ASNB 117 -14.958 -17.694-108.821 1.0024.84 B

ATOM 5644 O ASN B 117 -13.787 -18.056-108.620 1.00 23.03 B

ATOM 5645 N MET B 118 -15.749 -17.150-107.910 1.00 22.45 B ATOM 5646 CA MET B 118 -15.293 -16.910-106.567 1.00 20.78 B

ATOM 5647 CB MET B 118 -16.387 -r6.192-105.775 1.00 18.76 3

ATOM 5648 CG MET B 118 -15.964 -14.810-105.372 1.00 15.13 B

ATOM 5649 SD METB 118 -17.169 -13.570-104.846 1.00 16.98 B

ATOM 5650 CE METB 118 -18.617 -14.395-104.748 1.0O 15.12 B ATOM 5651 C METB 118 -14.928 -18.234-105.932 1.0021.25 B

ATOM 5652 O METB 118 -13.834 -18.403-105.385 1.0021.30 B

ATOM 5653 N SERB 119 -15.853 -19.179-106.038 1.00 20.97 B

ATOM 5654 CA SERB 119 -15.658 -20.519-105.504 1.00 21.91 B

ATOM 5655 CB SERB 1 L9 -16.897 -21.366-105.799 1.0021.77 B ATOM 5656 OG SER B l L9 -16.687 -22.719-105.445 1.00 23.72 B

ATOM 5657 C SER B 119 -14.412 -21.175-106.109 1.0023.13 B

ATOM 5658 0 SERB 119 -13.641 -21.846-105.418 1.0022.93 B

ATOM 5659 N ARGB 120 -14.220-20.952-107.409 LOO 25.21 B

ATOM 5660 CA ARG B 120 -13.093 -21.502-108.146 1.0025.74 B ATOM 5661 CB ARGB 120 -13.251 -21.191-109.640 1.00 25.73 B

ATOM 5662 CG ARG B 120 -12.309 -21.966-110.587 1.00 25.39 B

ATOM 5663 CD ARG B 120 -11.172 -2L11-7-111:090 1.00-23.39 B

ATOM 5664 NE ARG B 120 -1-1.668 -19.937-111.262 1,0023.57 B

ATOM 5665 CZ ARGHB 120 -10.902- IOlO-112.091 -1.0025.78_ B ATOM 5666 NHl ARG-BJ20 -9.60β--18;9H4-l 11.813 HX)-24.31 B

ATOM 566-7 -NHTARG B^" 120 -11.442 -177890-112.716 1.0028.15 B

ATOM 5ό68^~C ARGB 120 -11.802 -20.9O5- 107.614 1.0027701 -B

ATOM 5669 O ARGB 1-20 -10.863 -21.624-107-284 1.0027.86 B

ATOM 5670 N ILE B 121 -11.767 -19.584-107.523 1.0027.98_ B ATOM 5671 CA ILE B 121 -10.590 -18.887-107.035 1.00 30.63 B

ATOM 5672 CB ILE B 121 -10.854 -17.371-106.971 1.00 30.62 B

ATOM 5673 CG2 ILE B 121 -9.676 -16.648-106.322 1.00 30.68 B

ATOM 5674 CGl ILE B 121 -11.097 -16.840-108.378 1.0028.20 B

ATOM 5675 CDl DLE B 121 -11.667 -15.458-108.401 1.0027.91 B ATOM 5676 C BLE B 121 -10.159 -19.372-105.651 1.00 32.49 B

ATOM 5677 0 ILE B 121 -8.967 -19.617-105.403 1.00 33.30 B

ATOM 5678 N TYR B 122 -11.134 -19.518-104.760 1.00 32.97 B

ATOM 5679 CA TYR B 122 -10.864 -19.950-103.397 1.00 34.17 B ATOM 5680 CB TYRB 122 -12.146 -19.903-102.567 1.0035.64 B

ATOM 5681 CG TYRB 122 -11.945 -20.281-101.115 1.00 38.34 B

ATOM 5682 CDl TYRB 122 -11.444 -19.365-100.185 1.0038.30 B

ATOM 5683 CEl TYR B 122 -11.223 -19.734 -98.860 1.00 39.31 B

ATOM 5684 CD2 TYR B 122 -12.220 -^"21.570-100.67O 1.0040.0O B ATOM 5685 CE2 TYR B 122 -12.000 -21.945 -99.349 1.00 41.03 B

ATOM 5686 CZ TYRB 122 -11.501 -21.028 -98.452 1.0040.13 B

ATOM 5687 OH TYRB 122 -11.257 -21.437 -97.164 1.0040.45 B

ATOM 5688 C TYRB 122 -10.256 -21.338-103.298 1.00 34.42 B

ATOM 5689 0 TYR B -122 -9.246 -21.517-102.616 1.00 15.92 B ATOM 5690 N SERB 123 -10,866 -22.314-103.973 1.00 33.77 B

ATOM 5691 CA SER B 123 -10.388 -23.701-103.928 1.00 33.55 B

ATOM 5692 CB SERB 123 -11.537 -24.673-104.241 1.00 33-68 B

ATOM 5693 OG SERB 123 -12.574 -24.581-103.271 1.0034.62 B

ATOM 5694 C SERB 123 -9.223 -23.975-104.862 1.0032.06 B ATOM 5695 0 SERB 123 -8.863 -25.123-105.099 1.00 32.51 B

ATOM 5696 N THRB 124 -8.613 -22.911-105.358 1.00 3-1,24 B

ATOM .5697 CA THRB 124 -7.506 -23.038-10.6.286 1.O0 31J1 B

ATOM 5698 CB THR B 1Z4 -7.898 -22.438-107.654 1.00 31.9Θ B

ATOM 5699 OGl THR-B 12-fe -8τ831 -23.313-108.298 1.00-31.44 B: ATOM 5700 CGTTHR B- 124^" -6.675 -22.233-10&53J6 1,90=31.66 B-

ATΘM 5701 ^"C THRB 124 -6.258 -22.-343-105.774 1.0031.04 B

ATOM 5702 O THRB 1-24 -5.137 -22.724-106.132 1.Θ0 31.83 -B

ATOM 5703 N ALA B 125 -6.448 -21.325-104.936 1.00 30.07 B

ATOM 5704 -CA ALA B 125 -5.329 -20.549-104.385 1.Θ0-29..02 B ATOM 5705 CB ALA B 125 -5.818 -19.571-103.351 1.0028.34 B

ATOM 5706 C ALA B 125 -4.309 -21.479-103.778 1.0027.72 B

ATOM 5707 O ALA B 125 -4.639 -22.454-103.141 1.0028.36 B

ATOM 5708 N ALA B 126 -3.051 -21.147-103.977 1.0026.77 B

ATOM 5709 CA ALA B 126 -1.980 -21.985-103.498 1.0026.51 B ATOM 5710 CB ALA B 126 -1.432 -22.783-104.677 1.0026.27 B

ATOM 5711 C ALA B 126 -0.910 -21.075-102.923 1.0027.37 B

ATOM 5712 O ALA B 126 -0.938 -19.875-103.146 1.0027.53 B

ATOM 5713 N VAL-B 127 0,028 -21.639-L02.166 1.0028.67 B

ATOM 5714 CA VAL B 127 1.097 -2O.833-101.592 1.0029.91 B

ATOM 5715 CB VAL B 127 1.063 -20.816-100.034 1.0027.52 B

ATOM 5716 CGl VAL B 127 2.187 -19.938 -99.506 1.00 24.68 B

ATOM 5717 CG2 VAL B 127 -0.275 -20.325 -99.528 1.0022.63 B

ATOM 5718 C VAL B 127 2.426 -21.419-102.029 1.00 33.85 B^"

ATOM 5719 O VAL B 127 2-705 -22.596-101.774 1.00 33.92 B

ATOM 572G- N CYS B 128 3.249 -20.595-102.666 1.00 37.93 B

ATOM- 5721 CA CYS B 128 4.547 -21.044-103.140 1.0043.60 B

ATOM 5722 C CYS B 128 5.642 -20.398-102.359 1.0045.21 B

ATOM 5723 O CYS B 128 5.414 -19375-101.737 1,0.045.13 B

ATOM 5724- CB CYS B 128 4.709 -20.693-104.606 Ii)O 46,94 B

ATOM 5725 SG CYS B 128 3.323 -21.287-105.616 1.00 52.34 B

ATOM 5726 N LEU B 129 6.836 -20.971-1-02.417 1.0048.44 B

ATOM 5727 CA LEU B 129 7.936 -20.418-101.662 1.0052:64^" B

ATOM 5728 CB LEUB 129 8.456 -21.433-100.655 l.θO 53.11 B

ATOM 5729 CG LEU B 129 7.327-22.366-100,244 1.00 53.80 B

ATOM- 5730 CDl LELJ B 129 6.918 -23.245-101.426 1.00 53.79 B

AT-OM 5731 CD2 LEU B 129 7.810 -23.230 -99.125 LOO 53.33 B

ATOM 573-2- C LEU B 129 9,047 -20.023-102.544 LOO 55.54 B

ATOM 5733 -Θ- JtEUB 129- 9τH-7 -2U.470-103.686 L0.G-57.Q8- B - ATOM 5734 N PRO B 130 9.972 -19.204^101.999- 1 JftO 58.08 B-

ATOM: 5735^" CD-PRO B-T30 9.930 -18:694-100.61-5 1.00.58J4 -B

ATOM 5736 CA-PRO B 130 11.152 -18.706-102.7-1-8 LDO 60.19^" B

ATOM- 5737 CB PRO B 130 12.049 -18.158-101.618 1.00 59.42 B

ATOM 5738 CG PRO B 130 11.058 -17.700-100.575 1.00.58.82 B

ATOM 5739 C PRO B 130 11.776 -19.863-103.480 1.00 62.12 B

ATOM 5740 O PRO B 130 12.856 -19.775-104.059 1.00 62.59 B

ATOM 5741 N ASN B 131 11.049 -20.957-103.479 1.00 64.06 B

ATOM 5742 CA ASN B 131 11.471 -22.068-104.234 1.00 65.71 B

ATOM 5743 CB ASN B 131 11.098 -23.461-103.638 1.00 66.38 B ATOM 5744 CG ASNB 131 12.193-24.512-103.861 1.0067.38 B

ATOM 5745 ODl ASNB 131 11.966-25.727-103.8071.0068.05 B

ATOM 5746 ND2ASNB131 13.404-24.027-104.0801.0067.87 B

ATOM 5747 C ASNB 131 10.672-22.001-105,463 1.0066.69 B

ATOM 5748-0 ASNB 131 9.463-22.075-105.398 1.0067.26 B

ATOM 5749 N AIA B 132 1-1.227-21.652-106.581 1.0067.16 B

ATOM 5750 CA ALA B 132 10.255-22.159-107.5061.0067.33 B

ATOM 5751 CB ALAB 132 9.390-21.126-108.3541.0066.62 B

ATOM- 5752 C ALAB 132 -10.763-23.365-108.2521.0067.37 B

ATOM 5753 O ALAB 132 11.735-23.394-109.0421.0067.58 B

ATΘM 5754 ^■N ALA B 133 10.194-24.343-107.5861.0067-26 B

ATOM 5755 CA ALA B 133 10.275 -25.689-107.-863 1:0067.32 B

ATOM 5756 CB ALAB 133 10.494-26.416-106.519 1.0066.25 B

ATOM 5757 C ALA B 133 8.861-25.859-108.3071.0067.45 R.

ATOM 5758 O ALA^"B 133- ^•8.577-26.737-109.063 1.0067.53 B

ATOM 5759 N ALABlM 8.026-24.951-107.8081.0067.10 B

ATOM 5760 CA ALAB 134 6.573-25.000-107.9471.0065.84 B

ATOM 5761 CB ALA B 134 6.023 -25.225-109.428 1.0065.93 B

ATOM 5762 C ALA B 134 6.236 -26.219-107 '.045 1.0065.03 B

ATOM 5763 O ALAB 134 5.698-27.243-10.7.4691.0066.17 B

-AXOM 5764 N ALA B 135 6.666 -26.064-1Q5-SO3 1.0062.77 B

ATOM 5765- CA ALA=B 135 6.280-26:9-5.0-1-04.732 1.0059.80 B

ATOM- 5766 -CB ALAB 135 7.456-27.324-103.750 L00^~59.17 B

ACOM -5767 C ALA B 135 5.501 -25r744- 10-4.2271.005S-.27 B

ATOM^ ^"57-68- O ALAB 135- 6.053-2.4.650-104.120 1.0058.10 B

-ATOM- 5769 N CYS B 136- -4:209 -25.951-104.0361.0.0-55.72 B

ATθM^~ 5770-CA CYS B 136 3.310 -24.885-Ϊ03.6161.0052.97 B

ATOM 577-1 C CYS B 136 2.195-25.549-102.795 1.0051.69 B

ATOM 5772 O CYS B 136 1.553-26.494-103.2641.0051.48 B

ATOM 5773 CB CYS B 13« 2.688-24.161-104.844 1.0052.40 B

ATOM 5774 SG CYS B 136 3.707-23.250-106.033 1.0053.08 B

ATOM 5775 N TRPB 137 1.951-25.047-101.5901.0049.65 B

ATOM 5776 CA TRPB 137 0.952-25.656-100.731 1.0047.06 B

ATOM 5777 CB TRP B 137 1.263-25.386-99.256 1.0047.69 B ^

ATOM 5778 CG TRPB 137 2.634-25.690-98.8391.0047.40 B

ATOM 5779 CD2 TRP B 137 3.453-24.908-97.9561.0047.20 B

ATOM 5780 CE2 TRP B 137 4.688-25.578-97.833 1.0047.33 B

ATOM 5781 CE3TRPB137 J.264 -23.704 -97.258 1.0O 47.17 B ATOM 5782 CDl TRP B 137 3.374 -.26.772 -99.199 1.0047.43 B

ATOM 5783 NEITRPB 137 4.611 -26.712-98.598 1.0047.60 B

ATOM 5784 CZ2 TRP B 137 5.739-25.090-97.0391.0047.49 B

ATOM 5785 CZ3 TRP B 137 4.321-23.210-96.455 1.0047.17 B

ATOM 5786 CH2 TRP B 137 5.54-1 -23.911 -96361 1.0047.32 B ATOM 5787 C TRPB 137 -0.460 -25.183-100.877^" 1.004529 B

ATOM 57880 TRPB 137 -0:715 -24.005-101,056 IJOO 4^'4.54 B

ATOM 5789 N SERB 138 -1.412 -26.093-100.S191.0044:03- B

ATOM 5790 CA SERB 138 -2.722-25.519-100.7171.0043.59 B

ATOM 5791 CB SERB 138 -3.791- -25.863-101.7451.0043.73 B ATOM 5792 OG SERB 13S- -4.88S -24.985-101.4271.0042.72 B

ATOM 5793 C SERB 138 -3248-25.851-99.3481,0043.38 B

ATOM 5794 O SERB 138 -2.709-26.640-98.5671.0042.24 B

ATOM 5795 N LEUB 139 -4.327-25.160-99.089 1.0043.42 B

ATOM 5796 CA LEUB 139 -5.006-25.197-97.8261.0043.54 B ATOM 5797 CB LEU B 139 -6.275-24.384-97.948 1.0041.68 B

ATOM 5798 CG LEU B 139 -6.963 -24.026 -96.642 1.0040.74 B

ATOM^' 5799 CDl LEUB 139 -6.207 -22.929 -95,887 LOG 39.99 B

ATOM 5800.CD2-LEUB139 -&341 -2U 14 -9-7.0091.0.040:34 B

AFΘM 58OT C LEU Bl 39-- ~5.332--26.504 -97.141 1.0044.54 B ATOM 5802 α LEUB 139 -5τl47 -26.623-95:936 £0045.29 B

ATOM 5803 TSf ASPBT40- -5.769-27.504-97.881 H)G 46.00 B

ATOM 5S04-CA ASP^'B 140 -6.I49-28J7.46-9-7.23.71.0O-47.il B^"

ATOM 5805 CB ASPB 140 -7.657-28.767-97235 1.0048J -8 B

ATOM 5806 CG ASP B 140 -8.-189-30.128-97.053 1,0049.18 B ATOM 5807 ODl ASP B 140 -7.352-31.061-96.904 1.0048.84 B

ATOM 5808 OD2 ASP B 140 -9.429-30.287-97.053 1.0049.76 B

ATOM 5809 C ASPB 140 -5.621-29.790-98.177 1.0047.20 B

ATOM 5810 O ASPB 140 -6.223-30.114-99.175 1.0047.38 B

ATOM 5811 N PROB 141 -4.454-30.328-97.8371.0047.38 B ATOM 5812 CD PRO B 141 -4.018-31.498-98.618 1.0047.68 B

ATOM 5813 CA PRO B 141 -4.021-30.405-96.4371.0046.46 B

ATOM 5814 CB PRO B 141 -3.417-31.807-96.3371.0046.13 B

ATOM 5815 CG PRO B- 141 -2.994-32.133-97.7241.0046.66 B ^" ATOM 5816 C PRO B 141 -2.967-29.353-96.106 LOO 45r29 JB

ATOM 58170 PROB 141 -2.902 -28.884--94.9691.0044.04 B

ATOM 5818 N ASP B 142 -2.153-28.990-97.0921.0045.65 B

ATOM 5819 CA ASP B 142 -0.745-28.692-96.853 1.0045.20 B

ATOM 5820 CB ASP B 142 -0.079-28.189-98.135 1.0046.45 B ATOM 5821 CG ASP B 142 0.274-29.314-99.0881.0048.42 B

ATOM 5.822 ODl ASPB 142 1.105-30.170-98.719 1.00-49.44 B

ATOM 5823 OD2 ASP B 142 -0.229 -29_^423-100.2271.0Q 50.76 B

ATOM 5824 C ASPB 142 -0.574-27.668-95.735 1.0043.66 B

ATOM 5825 O ASP B 142 0.264 -27.836 -94.8501.0043.82 JB ATOM 5826 N LEUB 143 -1.373-26.607-95.783 1.0041.10 B

ATOM 5827 CA LEU B 143 -1.259-25.518-94.8201.0037.75 B

ATOM 5828 CB LEU B 143 -1.809-24.219-95.413 1.0035.53 B

ATOM 5829 CG LEU B 143 -1.179-23.749-96.725 1.0033.01 B

ATOM 5830 CDl LEUB 143 -1.911-22.531-97.2671.0032.08 B ATOM 5831 CD2 LEU B 143 0.300-23.450-96.535 1.0031.16 B

ATOM 5832 C LEUB 143 -1.990,-25.851 -93.523 1,0036.35- -B

ATOM 5833 O LEUB 143 -1.434-25.716-92.433 1.0034.32 ^"B'

ATΘM- 5.834-N THRB 144 -3-239-26^86-93,651 1.0035-36- B

ATOM 5835 CA THE B 144- -4.046^"-26.620 -92.513 kθO 35^:38~ B - ATOM 583-6.-GB-THRB 144 -5.186-27:530-92.9501.003430- B

AXOM 5837 OGtTSTB 144 -6=279-26.736-937435 1.003232 B

ATOM- 583TCG2THRB144 -5.620-28391-91.8141.00333-2 B

ATOM 5839 C TfIRB 144 -3.153 -27.332 -91.5051.0037.14 B

ATOM 5840 O THRB 144 -3.275 -27.11& -90305 1.0038.04 B ATOM 5341 N ASNB 145 -2.238 -2S7163 -91.995 1.0037.94 B

ATOM 5842 CA ASN B 145 -1.338-28.902-91.1141.0038.94 B

ATOM 5843 CB ASNB 145 -0.686-30.082-91.8451.0040J2 B

ATOM 5844 CG ASN B 145 -1.695-31.075-92.3751.0042.10 B

ATOM 5845 ODl ASNB 145 -2.827-31.162-91.8921.0042.58 B ATOM 5846 ND2 ASNB 145 -1.283-31.848-93.366 1.0044.53 B

ATOM 5847 C ASNB 145 -0.236-28.040-90.5301.0039.09 B

ATOM 5848 O ASNB 145 0.185-28.252-89.3941.0041.07 B

ATOM 5849 N BLEB 146 0.248-27.077-91.3061.0038.15 B ATOM 5850 CA -ILE B 146 1.315-26.210-90.831 1.0036.86 B.

ATOM 5851 CB ELEΕ 146 1.850-25.309-91.955 1.0036.90 B

ATOM 5852 CG2 LLE B 146 3.047-24.517-91.4631.0035.77 B

ATOM 5853 CGl ILE B 146 2.273-26.175-93.143 1.0037.96 B

ATOM 5854 CDl ILE B 146 2.910-25.412-94.2891.0036.94 B ATOM 5855 C ILE B 146 0.787-25.343-89.7071.0036.23 B

ATOM 5856 O^" ILE B 146 1.492,25.049-88.7471.0035.93 B

ATΘM 5857 N LEUB 147 -0.474-24:951-89.823 1.003.5.36 B

ATOM 5858 CA LEU B 147 -1.093-24.114-88.8141.0033.98 B

ATOM 5859 CB LEUB 147 -2.169-23.227-89.4361.0032.42 B ATOM 5860 GG LEU B 147 -1.659-21.802-89.635 1.0031.81 B

ATOM 5861 CDlLEUB 147 -1.236-21.608-91.0741.0030.71 B

ATOM 5862 CD2XEUB147 -2.752-20.811-89.2381.0031.32 B

ATOM 5863 C LEUB 147 -1.706-24.922-87.7021.0034.01 B-

ATOM 5864 O LEUB 147 -2.329-24.374-86.7991.0033.89 B ATOM 5865 N ALAB 148 -L537 -26.231 -87.7561.0034.92 B

ATOM 5866 CA ALA B 148 -2.117-27.064-86.723 1.0036.08 B

ATOM 5867 CB ALA B 14.8 -2.936 -28.I73 -87.33£ 1.0036-24 B

ATOM 5868 C ALA B 148 -1.044: -27.648 -85.8451.003635 B

ATOM- 5S69 O ALA B VtS -1.274 -27.874 -83J6601.00=38.39 B ATOM- -5870 N-SER-B-149 0.137 -27.8?fr--86:4061.0035.3-1- B ATOM- 5871 CA SER-B 149 1.213 -28.46&--8&6Z8- 1.0035,07 B

ATOM 5872 CB SER B 149 1.330 -^"29,940 -86.0021.0036.81 -B

ATOM 5S73 OG SERB 149 1,332-30.077-87.410 1.0039.45 B

ATOM 5874 G SER-B 149 2.586 -27.809 -85.713 1.0032.93 B ATOM 58750 SERB 149 3.526-28.208-85.0201.0033.67 B

ATOM 5876 N SERB 150 2.731-26.821-86.571 1.0030.68 B

ATOM 5877 CA SERB 150 4.015-26.154-86.6371.0028.07 B

ATOM 5878 CB SERB 150 4.167-25.404-87.9651.0027.41 B

ATOM 5879 OG SERB 150 5.348-24.617-87.961 1.0026.86 B ATOM 5880 C SERB 150 4.106-25.134-85.488 1.0026.21 B

ATOM 5881 O SERB 150 3.117-24.490-85.130 1.0023.45 B

ATOM 5882 N ARGB 151 5.274-25.015-84.869 1.0024.81 B

ATOM 5883 CA ARGB 151 5.426-23.984-83.834 1.0023.44 B

ATOM 5.884 -CB ARGB 151 5.674-24.495-82.411- 1.0022.35 B

ATOM 5885 CG ARGB 151 4.863-25.631-81.8971.0019.00 B

ATOM 5886 CD ARGB 151 3.429-25.466-82.183 1.0017.38 B

ATOM 5887 NE ARGB 151 2.644-26.329-81.3191.0018.84 B

ATOM 5888 CZ ARGB 151 1.359 -26.581 -E 1.5001.0020.59 B

ATOM 5889 NHl ARG B 151 0.702-27.375-80.6601.0019.94 B

ATOM 5890 NH2ARGB151 0.750-26.031-82.5291.0020.9Q. B

ATOM 5891 C ARG.B 151 6.637-23.1=63-84.179 1.0023.24 B

ATOM 5892 O ARGB 151 7.458-22.897-83.3171.0022.68 B

ATOM 5893 N SERB 152 6.767-22.814-85.452 1.0025.14 B

ATOM 5894 CA SERB 152 7.854 -.21.959 -85.910 1.0026.02 B

ATOM 5895 CB SERB 152 8.498-22.482-87.1931.0024.52 B

ATOM 5896 OG SERB 152 9.526-21.591-87.576 1.0025.70 B

ATOM 5897 C SERB 152 7.096-20.675-86.1-88 1.0026.21 B

ATOM 5898 O SERB 152 6.195-20.667-87.022 1.00.26.48 B

ATOM 5899 N TYRB 153 7.412 -19.606 -85.4661.0025.35 B

ATOM 3900 CA TYR-B 153 6.669-18.377-85.6801.0025.67 B

ATOM 590Ϊ CB TYRB 153 7.195-1-7.244-84.785 LOO 25.00 B

ATOM 5902 CG TYRB 153 6.384 -15.96-1-8.4.8511.0024.26- B

ATOM 5903_em TYRB 153 5.300 -15.745 -83.997 -1.0023.-67 B

ATOM 5904 CElTYRB 153 4.550 -14:5-71 -84τθ76 LOO 24.17 B

ATOM ^•5905 CD2TYRB-153 -6.692r-14.971 -S5.7861.0023.89 B

ATOM -5906 CE2TYRB153 5.947-13.804-85.876 1.0023.80 B

ATOM 5907 CZ TYRB 153 4.a§4- -13.611-85.0201.0024.60 B

ATOM 5908 OH TYRB 153 4.157-12=456-85.112 1.0026,11 B

ATOM 5909 C TYRB 153 6.750-17.962-87.140 1.0026.14 B

ATOM 5910 O TYRB 153 5.741-17.604-87.745 1.0026.74 B

ATOM 5911 N ALAB 154 7.954-18.032-87.705 1.0026.03 B

ATOM 5912 CA ALAB 154 8.176-17.643-89.0971.0025.11 B

ATOM 5913 CB ALAB 154 9.643-17.786-89.451 1.0025.63 B ATOM 5914 C ALA B 154 7.332-18.474-90.0421.0024.46 B

ATOM 5915 O ALAB 154 6.552-17.943-90.828 1.0025.21 B

ATOM 5916 N METB 155 7.478-19.787-89.955 1.0023.21 B

ATOM 5917 CA METB 155 6.717-20.652-90.8361.0022.99 B

ATOM 5918 CB METB 155 7.124 -22.091 -90.6261.0024.03 B

ATOM 5919 CG METB 155 6.973-22.855-91.8841.0027.92 B

ATOM 5920 SD MET B 155 7.763-24.399-91.6071.0034.80 B

ATOM 5921 CE MET B 155 6.332-25.360-91.3701.0031.67 B

ATOM 5922 C METB 155 5.208-20.526-90.71-41.0021.32 B

ATOM 5923 O METB 155 4.449-20.726-91.662 1.0021.92 B

ATOM 5924 N LEUB 156 4.764-20.187-89^271.0020.58 B

ATOM 5925 CA LEU B-156 3.341-20.047-893.16 1.0020.10 B

ATOM 5926 CB LEUB 156 3.033-20.058-87.802 1.0019.59 B

ATOM 5927 CG LEU B.156 3.079-21.416-87.103 1.0018.72 B

ATOM 5928 CDl LEU B 156 3.091-21.224-85.611 1.0019.74 B

ATOM 5929 CD2LEUB156 1.861-22.236-87.5221.-0O 19.83 B

ATOM 5930 C LEUB 156 2.913 -18,734-89.987 1.0019.88 B

ATOM 5931 O LEUB 156 1.869-18.646-90.636 1.0018.49 B

ATOM 5932 N LEUB 157 3.759 -17.722-89.862 1.0018.50 B

ATOM 5933 CA LEUB 157 3,469-16.424-90.446 1.0018.33 B

ATOM 5934 CB LEUB 157 4.531-15.417-90.011 1.0016.86 B

ATOM 5935 CG LEUB 15-7 4.506-13:997-90.574 1:0015.26 B

ATOM .5936- CDl LEU B 157 3.256 -13.275 -90.1121.0013.77^" B

ATOM 5937 CD2 LEU-R-157 5.772=13-261--90.122 1.0013.31 B

ATOM 5938 C LEUB 157 3.453 -1J5.51Q-91.961 1.0019.77 B

ATOM 5939 Θ LEUB 137 2.628-15.885-52.6471.0020:73 B

ATOM 5940 N PHEB 158 4.382-17-290-9274921.0020.75 B

ATOM 5941 CA PHEB 158 4.486-17.446-93.934 L0θ 20.62 B

ATOM 5942 CB PHE B 158 5.712-18.287-94.293 1.0021.27 B

ATOM 5943 CG PHE B 158 6.148-18.134-95.723 1.0021.65 B

ATOM 5944 CDl PHE B 158 6.842-17.009-96.129 1.0022.91 B

ATOM 5945 CD2PHEB 158 5.847-19.099-96.665 1.0021.76 B

ATOM 5946 CEl PHE B 158 7.227-16.843-97.450 1.0023.63 B

ATOM 5947 CE2PHEB158 6.231-18.939-97.991 1.0023.17 B ATOM 5948 CZ PHE B 158 6.920-17.810-98.3821.0022.93 B

ATOM 5949 C PHEB 158 3.233-18.084-94.5271.0020.35 B

ATOM 5950 O PHE B 158 2.730-17.633-95.5601.0021.75 B

ATOM 5951 N ALAB 159 2.733-19.129-93.873 1.00J7.82 B

5. ATOM 5952^~ CA ALAB 159 1.547-19.814-94.3471.0016.04 B-

A-TOM ^■3953^" CB ALAB 159 L406 -21.129 -93.6341.0015.87 B

ATOM 5954 C ALAB 159 0.294-18.973-94.143 1.0015.38 B

ATOM 5955 O ALAB 159 -0.616 -18.991 -94.9661.0015.77 B

ATOM 5956 N TRPB 160 0:248-18.242-93.0361.0014.96 B 0 ATOM 5957 CA TRPB 160 -0.904 -17.394 -92.7291.0014.33 B

ATOM 5958 CB TRP B- 160 -0.800 -16.794 -41308 1.0011.80 B

ATOM 5959 CG TRPB 160 -2.037-15.990-90.915 1.00-7.97 B

ATOM 5960 CD2TRPB160 -2.274-14.599-91.1681.005.92 B

ATOM 5961 CE2 TRP B 160 -3.594-14.313-90.7431.005.43- R 5- ATOM 5-962 CE3TRPB160 -1.500 -13.565 -91.7161.005.24 R

ATOM- 5963 CDl TRP B 160 -3.190-16.472-90.351 1.007.96 B

ATOM 5964 NEl TRPB 160 -4.129-15.471 -90.248- 1.005.08 B

ATOM 5965 CZ2TRPB 160 -4.157-13.037-90.8521.006,08 B

ATOM- 5966 CZ3 TRP B 160 -2.060-12.295-91.8251.004.61 B- 0 ATOM 5967 CH2 TRP B 160 -3.378 -12.043 -91.3941.004J70- B

ATOM 5968 C TRPB 160 -0.994-16.250-93.725 1.0014.41 B

ATOM 5969 Q TRPB 160 -2,037-16=927-94.333 1.0014.43 B

ATOM 5970 N GLU-B 161 0.09.8 -15.504 -93.853 1.0014.31 B

ATOM 5971 CA GLUB-161 0.144-14.380-94.773 1.0016_^03 _JB - ATOM 5972 CB. GLUB 16F 1.520 -13.716 -94.7081.0015.97 JB

ATOM 5973 CG GLUB-161 1.6-40 -12τ496~95.590^" I.ΘΘ 16.7Θ" B

ATOM 5974 GD GLUB-161 3.048-11.947-95.640 1.0019.47 B-

ATOM 5975 OEl-GLUB 161 3.213-10.762-96.0041.0020.43 B

ATOM 5976 OE2GLUB161 3.995-12.699-95.3271.0021.38 B 0 ATOM 5977 C GLUB 161 -0.104-14.907-96.189 1.0017.13 B

ATOM 5978 O GLUB 161 -1.006 -14.453 -96.8971.0016.80 B

ATOM 5979 N GLYB 162 0.711-15.880-96.581 1.0017.05 B

ATOM 5980 CA GLY B 162 0.586 -16.472 -97.8881.0017.04 B

ATOM 5981 C GLY B 162 -0.829 -16.848 -98.2861.0018.03 B ATOM 5982 O GLYB 162 -1.265 -16.505 -99.3881.0018.42 B

ATOM 5983 N TRPB 163 -1.548-17.555-97.4191.0017.52 B

ATOM 5984 CA TRPB 163 -2.902-17.957-97.7641.0018.08 B

ATOM 5985 CB TRPB 163 -3.496-18.906-96.7091.0016.49 B

ATOM 5986-GG TRP.B 163 -4.976 -19.095 -96.8521.0013.46 B

ATOM 5987 CD2TRPB163 -5.651-19.771-97.9101.0013.66 B

ATOM 5988 CE2TRPB 163 -7.039-19.583-97.708 1.0014.48 B

ATOM 5989 CE3TRPB163 -5.223 -20.512 -99.0171.0010.96 B

ATOM 5990 CDl TRPB 163 -57942-18.551-96.0701.0014.60 B

ATOM 5991 NEl TRPB 163 -7.r89--18.834 -96.573 1.0014.20 B

ATOM 5992 CZ2 TRP B 163 -8,004 -20ΠO8 -98.5751.0014.21 B

ATOM 5993 CZ3TRPB163 -6.174 -21.030 -99.874 LOO 11.79 B

ATOM 5994 CH2TRPB163 -7.554-20.826-99.651 1.0012.59 B

ATOM 5995 C TRPB 163 -3.803-16.747-97.933 1.0019.46 B

ATOM 5996 O TRPB 163 -4:588-16.667-98.879 1.0022.02 B

ATOM 5997 N HIS B 164 -3.678 -15.798 -97J3161.0019.18 B

ATOM 5998 CA HIS B 164 -4.490 -14.581 -97.043 1.0018.48 B

ATOM 5999 CB HIS B 164 -4.286-13.797-95.7571.0017.79 B

ATOM 6000 CG HIS B 164 -5.084-14.330-94.6221.0017.15 B

ATOM 6001 CD2HISB164 -6.268-13.925-94.103 1.0016.44 B

ATOM 6002 NDL HIS B 164- -4.7β5- -15.486 -93:9541.0016,64 B

ATOM 6003 CE1MS-BH64 -57679 -15.771 -93.0771.0017.30 B

ATOM- 6004 NE2-MSB164 -6.620 - 14-843 -93.1471.0014.62 JB

ATOM 6QB5 C ffiS^~B^"164 -4.257 -13.659 -98.223 JLOO 18JO8 -B

ATOM 6006 O HIS-B-164 -5^165-12.968-98.705 1.0017.84 B

ATOM 6007 N- ASNB 165 -3.020-137619-98.663 1.00-1642^" B-

ATOM 6008 CAASN3-L65 -2.732-12.805-99.792 LOG 16.43 B

ATOM 6009 CB ASN-B 165 -1.244-12.505-99.889 LOO 15.71 B

ATOM 6010 CG ASNB 165 -0.783-11.491-98.9991.0016.39 B

ATOM 6011 ODl ASNB 165 -1.602-10.757-98,4191.0016.67 B

ATOM 6012 ND2ASNB165 0.537-11.334-98.891 1.0015.39 B

ATOM 6013 C ASNB 165 -3.241-13.467-101.033 1.0016.71 B

ATOM 6014 O ASNB 165 -3.905-12.860-101.869 1.0014.68 B

ATOM 6015 N ALA B 166 -2.933-14.748-101.115 1.0018.16 B ATOM 6016 CA ALA B 166 -3.304 -15.543-102.254 1.00 19.26 B

ATOM 6017 CB ALA B 166 -2.647 -16.892-102.151 1.00 17.91 B

ATOM 6018 C ALA B 166 -4.800 -15.709-102.477 1.0020.39 B

ATOM 6019 O ALAB 166 -5.260 -15.720-103.616 1.0023.38 F ATOM 6020 N ALAB 167 -5.568 -15.-7-89-101.4.03 1.0021.05 B

ATOM 6021 CA ALA B 167 -7.004 -16.004-101.525 1.0021.95 B

ATOM 6022 CB ALA B 167 -7.457 -16.933-100.402 1.00 21.71 B

ATOM 6023 C ALA B 167 -7.937 -14.787-101.586 1.00 22.54 B

ATOM 6024 O ALA B 167 -8.875 -14.765-102.376 l.OO^'24^3 B ATOM 6025 N GLY B 168 -7.700 -13.779-100.761 1.00 21.69 B

ATOM -6026 CA GLY B 168 -8.601 -12V644-100.751 1.00 21.51 B

ATOM 6027 C GLY B 168 -8.350 -11.499-101.711 1.0021.46 B

ATOM 6028 O GLY B 168 -9.292 -10.838-102.137 1.0023.65 B

ATOM 6029 N ILE B 169 -7.097 -11.228- 1-02.04J 1.00 19.19 B ATOM 6030 CA EJE B 169 -6.810 -10.146-102.964 1.00 16T92 B

ATOM 6031 CB ELE B 169 -5.282 -10.039-103.185 1.00 16.07 B

ATOM 6032 CG2 ILE B 169 -4.957 -9.110-104.358 1.00 14.72 B

ATOM 6033 CGl DLE B 169 -4.626 -9.540-101.895 1.00 13.20 B

ATOM 6034 CDl ELE B 169 -3.120 -9.333-102.002 1.00 9.19 B ATOM 6035 C ELE B 169 -7.551 -10.281-104.313 1.00 17.04 B

ATOM 6036 O ELE-B 169 -8.325 -9.4D3- 104.696 1.00-18715 B

ATOM 6037 N PRO B 170 -7.351 -11.393- 1Θ5.G32 1.00 16.50 B-

ATOM 6638 CD PRO B .1-70 -6,653 -12.632-404.627 1.00 16.26 B

ATOM 6039 €A PRGfB- 170 -8.Q22--l-l:.573-l;06.323 1.00 15.16 B - ATOM 6040 CB -PRO Br 170 -7.409 -12:862-106.834 1.00 16:08 B

ASQM 6041 CG PRO B 170^" -772I52-13.6£8-1O5.542 1.00 15.82 B

ATOM 6042 C PRO B-170' -9.531 -11.703-IQ6.218J-.00 15.25 B

ATOM 6043 O PRO B 170 -10.248 -11.497-107.180 1.00 15.75 B

ATOM 6044 N LEU B 171 -1Q.016 -12.037-105.038 1.00 14.89 B ATOM 6045 CA LEU B 171 -11.438 -127268-104.831 1.00 14.34 B

ATOM 6046 CB LEUB 171 -11.556 -13.226-103.661 1.00 15.47 B

ATOM 6047 CG LEU B 171 -12.733 -14.165-103.467 1.00 17.14 B ATOM 6048 CDl LEUB 171 -13.199 -14.699-104.806 1.00 16.80 B ATOM 6049 CD2 LEU B 171 -12.289 -15.295-102.540 1.00 14.00 B _5fJ9

ATOM 6050 C LEU B 171 -12.243 -11.008-104.548 1.00 14.28 B

ATOM 6051 O LEU B 171 -13.471 -10.946-104.674 1.00 13.62 B

ATOM 6052 N LYS B 172 -11.528 -9.978-104.159 1.00 14.49 B

ATOM 6053 CA LYS B 172 -12.196 -8.757-103.794 1.00 15.69 B ATOM 6054 CB LYS B 172 -11.172 -7.794-103.275 1.00 19.13 B

ATOM 6055 CG LYS B 172 -11.795- -6.621-102.668 ϊ.00 21.33 B

ATOM 6056 CD LYS B 172 -10.740 -5.862-102.020 1.00 23.56 B

ATOM 6057 CE LYS B 172 -11.326 -4.620-101.467 1.0026.63 B

ATOM 6058 NZ LYS B 172 -10.464 -4.152-100.352 1.0031.83 B ATOM 6059 C LYS B 172 -13.047 -8.071-104.837 1.00 13.02 B

ATOM -6060 O LYS B 172 -14.225 -7.768-104:607 1.00 13.18 B

ATOM 6061 N PRO B 173 -12.454 -7.793-106.001 LOO 15.76 JB-

ATOM 6062 CD PRO B 173 -11.124 -8.182-106.494 1.00 15.07 B

ATOM 6063 CA PRO B 173 -13.225 -7.130-107.042 1.00 15.15 B ATOM 6064 CB PRO B 173^' -12.279 -7.150-108.228 1.00 15.18 B

ATOM 6065 CG PRO B 173 -11.364 -8.319-107.929 1.00 15.16 B

ATOM 6066 C PROB 173 -14.527 -7.865-107.288 1.00 15.62 B

ATOM 6067 O PRO B 173 -15.555 -7.234-107.499 1.00 15.44 B

ATOM 6068 N LEU B 174 -14.527 -9.189-107.203 1.00 16.26 B ATOM 6069 CA LEU B 174 -15.793 -9.845-107.463 1.00 18.34 B

ATOM 6070 CB LEUB 174 -15.641 -11.284-1:07.965 1.00 17.37 B.

ATOM 6071 CG LEU B 174- -14.270 -11.9117-108.149 1.00 16.97 B

ATOM 6072. CDl LEU B-l-74 -14310 -12.767-109.392 1.0046.23 B

ATOM 6073 CD2 LEU-B 174 43.203 40;885-r0^"8.353 1.00 17.87 B -ATOM 6074 C LEU B4r74- 46.778 -9.8594-06.339 1.00 20.94 B^~

ATOM 6075 JD LEU B 174 47:981 -9.921-1-06.607 1:00 21.5? B

ATOM 6076 N TYRB175 -16303 -9.845-105-089 1.00 21.63 B

ATOM 6077 CA TYRB 175 47.243 -9.869-103.972 1.00.19.63 B

ATOM 6078 CB TYR B 175 -16.528 -9.958-102.611 1.0022.02 B ATOM 6079 CG TYR B 175 -17.449 -10340-101.459 1.0022.88 B

ATOM 6080 CDl TYR B 175 -17.95741.636-101353 1.00 24.34 B

ATOM 6081 CEl TYRB 175 -18.857 -11.985400.356 1.0024.46 B

ATOM 6082 CD2 TYRB 175 -17.864 -9.398-100.525 1.00 22.88 B

ATOM 6083 CE2 TYRB 175 -18.769 -9738 -99.520 1.0025.41 B _,.

DoU

ATOM 6084 CZ TYRB 175 -19.259 -11.034 -99.448 1.0025.17 B

ATOM 6085 OH TYRB 175 -20.161 -11.384 -98.478 1.0027.04 B

ATOM 6086 C TYRB 175 -18.080 -8.603-104.029 1.00 19.04 B

ATOM 6087 O TYRB 175 -19.234 -8.607-103.632 1.00 18.41 B ATOM 6088 N GLUB 176 -17.498 -7.524-104.544 1.00 18.85 B

ATOM 6089 CA GLUB 176 -18.204 -6.251-104.657 1.0020.88 B

ATOM 6090 CB GLUB 176 -17.235 -5.140-105.030 1.00 20.56 B

ATOM 6091 CG GLU B 176 -15.997 -5.124-104.177 1.00 21.30 B

ATOM 6092 CD GLU B 176 -14.932 -4.210-104.7Z8^~ 1.00 21.50 B ATOM 6093 OEl GLU B 176 -15.292 -3.119-105.208 1.00 20.65 B

ATOM 6094 OE2 GLU B 176 -13.738 -4.575-LQ4.669 1.00 23.24 B

ATOM 6095 C GLU B 176 -19.313 -6.304-105.698 1-0022.76 B

ATOM 6096 O GLUB 176 -20.404 -5.775-105.473 1.00 24.42 B

ATOM 6097 N ASPB 177 -19.041 -6.936-106.840 1.0023.23 B ATOM 6098 CA ASPB 177 -20.059 -7.030-107.895 1.0024.19 B

ATOM 6099 CB ASP B 177 -19.459 -7.546- 1Θ9.20-1 1.0024.95 B

ATOM 6100 CG ASPB 177 -18.441 -6.586-109.798 1.00 25.37 B

ATOM 6101 ODl ASP B 177 -18.601 -5.359-109.638- 1.00 25.89 B

ATOM 6102 OD2 ASPB 177 -17.479 -7.053-110.446 1.00 26.47 B ATOM 6103 C ASP B 177 -21.168 -7.961-107.454 1.0024.03 B

ATOM 6104 O ASP B 177 -22.359 -7.697-107.653 1.00 23.46 B

ATOM 6105- N PHE B 178 -20.749 -9.054-106.843 T.-ΘO 23.99 B

ATOM 6-106 CA PHE.B- 178 -21.689 -10:015-LΘ6.342 1.00 25.53 B

ATOM 6107 CB PHE B 178 --2Θ.97T-1T.114-105-.607 1.0.026:15 B- ATOM 6108 CG EHE B 178 -21.84^11.776-104^09 1.0028.38 B

ATOM- 6-109- CDl PHE B 178 -.22.82T -12.677-105:035 -IM 29:65 B

ATOM- 6110 CD2 PHE B 178- -21.735.-11.465-103^51 1.002-8.21 B.

ATOM 61 U CEl PHE B 178 -23.700 -13.278-1.04.127 1.0030.32 B

ATOM 6112 CE2 PHE B 178 -22.601 -12.051-102.318 IJQO 27.79 B ATOM 6113 CZ PHE B 178 -23.592 -12.969-102.754 1.00 28.25 B

ATOM 6114 C PHE B 178 -22.638 -9.367-105.347 1.00 27.01 B

ATOM 6115 O PHE B 178 -23.857 -9.556-105.375 1.00 27.99 B

ATOM 6116 N THRB 179 -22.040 -8.621-104.432 1.00 27.45 B

ATOM 6117 CA THR B 179 -22.795 -7.955-103.389 1.00 28.19 B _5gl

ATOM 6118 CB THR B 179 -21.847 -7.180-102.427 1.0028.41 B

ATOM 6119 OGl THRB 179 -20.866 -8.087-101.915 1.00 31.13 B

ATOM 6120 CG2 THRB 179 -22.609 -6.607-101.242 1.00 25.51 B

ATOM 6121 C THRB 179 -23.852 -7.019-103.958 1.00 28.32 B ATOM 6122 O THRB 179 -25.011 -7.057-103.545 1.00 30.70 B

ATOM 6123 N ALA B 180 -23.481 -6.210-104.938 1.00 27.54 B

ATOM 6124 CA ALA B 180 -24.446 -5.272-105.504 1.0026.94 B

ATOM 6125 CB ALAB 180 -23.778 -4.371-106.514 1.0026.45 B

ATOM 6126 C ALA B 180 -25.591 -5.992-106.157 1.0026.26 B ATOM 6127 0 ALA B 180 -26.738 -5.572-106.066 1.00 27.75 B

ATOM 6128 N LEUB 181 -25,265 -7.069-106.846 1.0024.9S B

ATOM 6129 CA LEU B 181 -26.281 -7.S38-107.529 1.00 26.64 B

ATOM 6130 CB LEU B 181 -25.619 -8.861-108.438 1.0026.94 B

ATOM 6131 CG LEU B 181 -25.288 -8.251-109.794 1.00 26.14 B ATOM 6132 CDl LEUB 181 -24.381 -9.175-110.579 1.0026.43 B

ATOM 6133 CD2 LEU B 181 -26.594 -8.035-110.543 1.0024.93 B

ATOM 6134 C LEU B 181 -27.246 -8.534-106.597 1.00.27.92 B

ATOM 6135 O LEU B 181 -28.479 -8.437-106.756 1.0027.29 B

ATOM 6136 N SERB 182 -26.663 -9.241-105.62S 1.00 28.74 B ATOM 6137 CA SERB 182 -27.411 -9.983-104.627 1.00 27.40 B

ATOM 6138 CB SERB 182 -26.447 -10.610-103.623 1.0027.80 B

ATOM 6139 OG SERB182 -27.144 -11.513-102.785 1.0028.99 B

ATOM 6140 C SERB 182 -28.398- -9.060-103.921 1-0025.74 JB

ATΘM 6141 O SERJBJ82 -29.453 -9.485-103.4-59 1.0025.91 B ATOM 6142 N ASNB 183 -28.060 -7-78€-L03.873- 1.0023.38 JBL

ATOM 6143 CA ASNB 183 -28.926 -6.827-103:242 1.0025.63 B

ATOM 6144 CB ASN B 183 -28.124 -5.606-102.815 1.00 26.92 B

ATOM 6145 CG ASN B 183 -27.634 -5.706-101.388 1.00 27.35 B

ATOM 6146 ODl ASN B 183 -26.767 -6.509-101.071 IDO 28.63 B ATOM 6147 ND2 ASN B 183 -28.203 -4.893-100.515 1.0029.53 B

ATOM 6148 C ASNB 183 -30.072 -6.411-104.160 1.00 26.80 B

ATOM 6149 O ASNB 183 -31.244 -6.396-103.744 1.00 28.18 B

ATOM 6150 N ALAB 184 -29.742 -6.068-105.405 1.0027.50 B

ATOM 6151 CA ALA B 184 -30.771 -5.673-106.373 1.0027.02 B ATOM 6152 CB ALA B 184 -30.160 -5.507-107.717 1.0026.16 B

ATOM 6153 C ALA B 184 -31.761 -6.794-106.412 1.00 26.89 B

ATOM 6154 O ALA B 184 -32.975 -6.610-106.374 1.00 26.84 B

ATOM 6155 N ALA B 185 -31.219 -7.996-106.474 1.0026.51 B

5 ATOM 6156 CA ALA B 185 -32.050 -9.174-10J6.502 1.00 26.65 B

ATOM 6157 CB ALA B 185 -31.219 -10.420-106.352 1.00 24.51 B

ATOM 6158 C ALA B 185 -33.106 -9.121-105.406 1.00 27.66 B

ATOM 6159 O ALA B 185 -34.289 -8.851-105.674 1.0027.89 B

ATOM 6160 N TYRB 186 -32.659 -9.322-104.167 1.00 28.04 B O ATOM 6161 CA TYRB 186 -33.549 -9.347-103.018 1.00 27.62 B

ATOM 6162 GB TYRB 186 -32.794 -9.895-101.814 1.00 22.75 B

ATΘM 6163 CG TYRB 186 -32.556 -11.382-101.912 1.00 L8..32 B

ATOM 6164 CDl TYR B 186 -31.280 -11.895-102.118 1.00 16.44 B

ATOM 6165 CEl TYRB 186 -31.0.67 -13.270-102.221 1.00 15.23 B 5 ATOM 6166 CD2 TYR B 186- -33.621 -12.281-10L814 1.00 17.38 B

ATOM 6167 CE2 TYRB 186- -33.424 -13.657-101.923 1.00 15.86 B

ATOM 6168 CZ TYRB 186 -32.143 -14,144-102.126 1.00 15.68 B

ATOM 6169 OH TYRB 186 -31.926 -15.500-102.249 1.00 13.48 B

ATOM 6170 C TYR B 186 -34.295 -8.075-102.646 1.0029.86 B 0 ATOM 6171 O TYR B 186 -35.322 -8.161-101.981 1.00 31. IS B

ATOM 6172 N ALA B 187 -33.827 -6.909-103-032 1.00 31.67 B

ATOM 6T73 CA-ALA B 187 -34.519 -5.669-102.73:4 1,00 34.85 B

ATOM 6174 CB ALA B 187 -33.754 -4.464-103.242 1.00 32.98- B

ATOM 615:5 C ALA B 187 -3-5.873 -5.705-1 Θ33S0- LOO 37.16 B 5- ATOM 6176- O ALA B 187 -36.764 -4-.9-r5-l-03.07-8 1.00 38.06 B

ATOM^" 61-77-N GEITB iS8 -36.013 -6:63(5- 104.304 LOQ 39r96 B

ATOM 617S^~ CA GLN B 188 -37.258- -6.767-1-05.028. 1.0042.59 B

ATOM 6179 CB GLN B 188 -36.973 -7.171-106.413 1.00 44.22 B

ATOM 6180 CG GLN B 1-88 -37.274 -6.146-107.390 1.0045.43 B O ATOM 6181 CD GLN B 18S -36.797 -6.667-108.674 1.0046.75 B

ATOM 6182 OEl GLN B 188 -36.847 -7.890-108.894 1.00 46.68 B

ATOM 6183 NE2 GLN B 188 -36.289 -5.786-109.535 1.00 48.06 B

ATOM 6184 C GLN B 188 -38.194 -7.779-104.437 1.00 43.81 B

ATOM 6185 O GLNB 188 -39.337 -7.936-104.881 1.00 43.95 B -,_

563

ATOM 6186 N ASPB 189 -37.688 -8.477-103.4361.0045.04 B

ATOM 6187 CA ASPB 189 -38.478 -9.457-102.7481.0045.92 B

ATOM 6188 CB ASPB 189 -37.633-10.671-102.409 1.0046.57 B

ATOM 6189 CG ASPB 189 -37.180-11.392-103.6421.004S.30 B ATOM 6190 ODl ASPΕ 189 -37.531-10.890-104.733 1.0047.98 B

ATOM 6191 OD2 ASP B 189 -36.489-12.434-103.511 1.0049.18 B

ATOM 6192 C ASPB 189 -38.998 -8.788-101.516 1.0046.02 B

ATOM 6193 O ASP B 189 -39.673 -9.407-100.712 1.0046.10 B

ATOM -6194 H GLYB 190 -38.685 -7.502- 101.393 1.0045.80 B ATOM 6195 CA GLYB 190 -39.159 -6.742-100,2581.0046.37 B

ATOM 6196 C GLY-B 190 -38.188 -6.334-99.158 1.00-46.23 B ATOM 61W O GLY^~B 190 -38.523 -5.455-98.354 1.0046.49 B

ATOM 6198 N PHE B 191 -36.998 -6.933-99.1091.0045.08 B

ATOM 6199 CA PHEB 191 -36.037 -6.600-98.060 1.0044.58 B ATOM 6200 CB THE B^" 191 -35.190 -7.818-97.7291.0045.22 B

ATOM 6201 CG PHE-B 191 -35.982 -9.081-97.5851.0046.24 B

ATOM 6202 CDl PHE B 191 -36.299 -9.843-98.695 1.0046.21 B

ATOM 6203 CD2 PHE B 191 -36.367 -9.540-96.334 1.0046.78 B

ATOM 6204 CEl PHE B 191 -36.979-11.051-98.559 1.0046.61 B ATOM 6205 CE2 PHE B 191 -37.051 -10.751 -96.195 LOO 47.13 B

ATOM 6206- CZ PHE B 191 -37.352 -11.503 -97.3091.0046.28 B

ATOM 6207 C PHEB 191 -35.119 -5.438-98.399 1.0043.78 B

ATOM 6208 O PHEB 191 -34τ8S9 -5.157 -99.57JL 1.0043.28 B

ATOM 6209 N THRB-192 -34.59-7- -4.769 -97.368 1.00-42.67. B ATOM- 6210 CA THErB 152 -33.685 -3.637 -97.560 1.0041.56 ^"B

ATOM 6211 CB THKrB- 192- -33.314 -2.974-96.216-1.0041.69 B-

ATOM JS212 OGl THR^- 192 -347413 -2.175-95.7641.0043.45 B

ATOM 6213 CG2 THR B 192- -32.072 -2.091-96.3691.0042.62 B

ATOM 6214 C THRB 192 -32.396 -4.059-98.262 LOO 40.18 B ATOM 62150 THRB 192 -31.895 -3.352-99.133 1.0039.63 B

ATOM 6216 N ASPB 193 -31.860 -5.210-97.8741.0039.26 B

ATOM 6217 CA ASP B 193 -30.641 -5.727-98.4741.0038.67 B

ATOM 6218 CB ASPB 193 -29.420 -5.010-97.9061.0040.02 B

ATOM 6219 CG ASPB 193 -29.367 -5.045-96.3901.0042.23 B j 64

ATOM 6220 ODl ASP B 193 -29.086 -6.126-95.8241.0041.78 B

ATOM 6221 OD2 ASP B 193 -29.607 -3.985 -95.762 l.GO 43.01 B

ATOM 6222 C ASPB 193 -30.540 -7.219-98.225 1.0038.48 B

ATOM 6223 O ASPB 193 -31.352 -7.779-97.489 1.0038.00 B ATOM .6224 N THR B 194- -29.558- -7.868 -98.8441.0038.23 B

ATOM 6225 CA THRB 194 -29.406 -9^306-98.665 1.0038.64^" -B

ATOM 6226 CB THRB 194 -28.119 -9.828-99.303 1.0038.15 B

ATOM 6227 OGlTHRB 194 -28.139 -9.546-100.701 1.0038.57 B

ATOM 6228 CG2 THR B 1-94^" -28.010~ir.329 -99.108- 1.0038.32 B ATOM 6229 C THRB 194 -29.378 -9.645 -97.1S81.0038.85 B

ATOM 6230 O THRB 194- -29.977-10.629-96.7541.0038.83 B

ATOM 6231 N GLYB-195 -28.680 -8.817-96.4191.0Q-39.06 B

ATOM 6232 CA GLYB 195 -28.583 -9.040-94.991 1.0039.66 B

ATOM 6233 C GLYB 195 -29.916 -9.300-94.3101.0039.72 B ATOM 6234 O GLY B- 195 -30:059-10241 -9-K5371.0040.01 B

ATOM 6235 N ALAB 196 -30.904 -8.469-94.6061.0039.43 B

ATOM 6236 CA ALAB 196 -32,216 -8.615-93.998 1.0038.88 B

ATOM 6237 CB ALAB 196 -33.086 -7.439-94.372 1.0038.98 B

ATOM 6238 C ALAB 196 -32.916-9.910-94.372 1.0038.56 B ATOM 6239 O ALAB 196 -33.716-10.426-93.603 1.0038.94 B

ATOM 6240 N TYR-B -TS7 -32.649 -10.4T1 -95.5701.0038.57 B

ATOM 624J CA TYRB 197 -331269-11.647^~95T995 1.0039.09 B

ATOM 6242-CB TYR B 197 -33.025. -11.868 -97.484 hOO 3&92 B ATOM^" 6243 CG TYR-B-497 -33.439 -13.243 =97.953 1.0037.98- B ATOM 6244 CDl TYRB-19-7-- -34:791-13.575-9871-25 1Λ036.35 B

ATOM 6245 CEl TYR-B 197 -35.162 -14.863 -98r527JL003ότl5 -B ATOM ~6246 CD2 TYR B 197 -32A66.-14.230 -98.1981.0037.12 B

ATOM 6247 CE2 TYRB 197 -32.816 -T5^".5O7 -98.595 ITOO 35.41 B

ATOM 6248 -CZ TYRB 197 -34.160-15.823-98.76-1 1.0035.75 B ATOM 6249 OH TYR B 197 -34.481-17.111-99.1321.0036.39 B

ATOM 6250 C TYRB 197 -32.703-12.807-95.1891.0039.86 B

ATOM 6251 O TYRB 197 -33.440-13.661-94.690 1.0040.36 B

ATOM 6252 N TRPB 198 -31.384-12.824-95.0581.0040.80 B

ATOM 6253 CA TRPB 198 -30.718-13.885-94.3101.0042.70 B JOJ

ATOM 6254 CB TRPB 198 -29.214-13.643-94.3071.0043.40 B

ATOM 6255 CG TRPB 198 -28.568-13.983-95.595 1.0043.89 B

ATOM 6256 CD2 TRP B 198 -27.164-14.088-95.8401.0044.96 B

ATOM 6257 CE2 TRP B 198 -27.002-14.435-97.198 1.0044.59 B

5 ATOM 6258 CE3 TRPB 198 -26.022 -13.920 -95.043 bβO 44.46 B

ATOM 6259 CDl TRP B 198 -29.187-14.261-96.7791.0044.44 B

ATOM 6260 NEl TRPB 198 -28.252-14.535-97.750 1.0044.69 B

ATOM 6261 CZ2 TRP B 198 -25.744-14.617-97.7741.0044.63 B

ATOM 6262 CZ3 TRPB 198 -24.772-14.100-95.616 1.00-43.97 B

10 ATOM 6263 CH2 TRP B 198 -24.644-14.445-96.968 1.0044.36 B

ATOM 6264 C TRPB 198 -3L238 -13.955 -92.8801.O043.16 B

ATOM 62650 TRPB 198 -3-1.622-11025 -92.395- LOO 41.98 B

ATOM 6266 N ARGB 199 -31.251-12.811-92.204 1.0043.72 B

ATOM 6267 CA ARGB 199 -31.799-12.725 -90.8561.0045.13 B

15 ATOM 6268 CB ARGB 199 -31.740-11.285 -90.344 1.0043.47 B^"

ATOM 6269 CG ARG B 199 -30.525 -10.981 -89.4841.0041.80 B

ATOM 6270 CD ARGB 199 -29.712 -9.78« -89.9591.0040.41 B

ATOM 6271 NE ARGB 199 -30.563 -8.663-90.3361.0040.34 B

ATOM £272 CZ ARGB 199 -30.116 -7.542-90.885 1.0041.30 B

20 ATOM 6273 NHl ARC- B 199 -30.963 -6.570-91.196 1.0041.01 B

ATOM 6274 NH2 ARG B 199 -28.820 -7.389 -91.Ϊ2B. LOG 42.14 B

ATOM 6275 C ARGB 199 -33.234 -13J241 -90.8101.0046.37 B

ATOM 6276 O ARGB 199 -33.610-13τ974-89.896 LΘ046.68 B.

ATOM -6277 N ALAB 2-00 -J4-.03Θ -12.853 -91.8Ob 1.00^v47.55 B

^■2S- ATΘM 62-78-CA ALA B 200 -35.473. -13.057 -91.749^"l=00-4&87 B

ATOM 6279-eS ALA B 200 -36.134 -12.484 -92τ993 XOO 47.82 B

ATOM 6280 C^" ALA B 200- -35.817-14.534-91.5941.90-50.27 B

ATOM 6281 O ALAB 200 -36.989-14.912-91.5891.0051-03 B

ATOM 6282 N TRPB 201 -34.788 -15.36fi.-91.466 1.00-51.51 B

30 ATOM 6283 CA TRP B 201 -34.973-16.811-91.415 1.0053.05 B

ATOM 6284 CB TRPB 201 -33.720-17.530-91.920 1.0055.30 B

ATOM 6285 CG TRPB 201 -33.630-17.600-93.414 1.0058.49 B

ATOM 6286 CD2 TRP B 201 -32.438-17.719-94.198 1.0059.80 B

ATOM 6287 CE2 TRP B 201 -32.825-17.749-95.553 1.0060.50 B ATOM 6288 CE3 TRP B 201 -31.075-17.805-93.8921.0060.69 B

ATOM 6289 CDl TRP B 201 -34.666-17.563-94.302 1.0059.93 B

ATOM 6290 NEl TRP B 201 -34.192-17.651-95.589 1.0060.92 B

ATOM 6291 CZ2TRPB201 -31.905-17.860-96.593 1.0061.42 B ATOM 6292 CZ3 TRP B 201 -30.164-17.914-94,926 1.006L56 B

ATOM 6293 CH2 TRP B 201 -30.583-17.941-96.2591.0061.51 B

ATOM 6294 C TRP B 201 -35.308-17.274-90.001 1.0053.41 B

ATOM 6295 O TRP B 201 -35.789-18.389-89.8001.0054.91 B

ATOM 6296 N^" TYRB 202 -35.Q51 -16.410 -89.025 1.0052.85 B ATOM 6297 CA TYR B 202 -35.253 -16.746 -87.650 1.005L35 B

ATOM 6298 CB TYR B 202 -34.039 -16.289-86.8461.0051.25 B

ATOM 6299 CG TYR B 202 -32.753-16.970-87.2651.0049.67 JB

ATOM 6300 CDl TYR B 202 -31.926-16.404-88.233 1.0048.37 B

ATOM 6301 CEl TYR B 202 -30.753-17.023-88.6181.0046.70 B ATOM 6302 CD2 TYR B 202 -32.368-18.185-86.6941.0048.75 B

ATOM 6303 CE2TYRB202 -31.199-1O14-87.0721.0047.27 B

ATOM 6304 JCZ TYR B 202 -30.394-18.224-88.033 1.0047.21 B

ATOM 6305 OH TYR B 202 -29.218-18.829-88.398 1.0048.08 B

ATOM- 6306 C TYRB 202 -36.545-16.096-87.153 1.0050.76 B ATOM 6307 O TYRB 202 -36.892-1-6.188-86.003 1.0051.07 B

ATOM 6308 N^~ ALA B 203 -37.269 -15.41S^"-88.025 1.0045.79 B

AΦOM 6309 CA ALAB203 -38.530-14.809 -87.604 LOO 48v41 B

ATOM 63 IG-CB ALAJ3203 -39.664-15.805=87.806 LOO 48.09 -B

ATOM 631T C ALA B 203 -38.543 -14J33. -86.1-53 1,0047762 B ATOM 63=1-2 O ALA-Bl203 -39-176-14.917-85.2841.0Θ-48.83 B

ATOM- 6313 N ALAB 2O4 -37.839-13.215=85.901 1.00-45.65 B

ATOM 6314 CA ALA.B 204 -3777-80-12:612-84.575 1.0043.38 B

ATOM- 6315 CB ALAB 204 -36.710-13.282-83.7371.0042:68- B

ATOM 63-16 C ALA B 204 -37.462 -1L137 -84.733 1.0042.34 B. ATOM 6317 O ALAB 204 -36.386 -1OJ781 -85.2001.0042.74^" B

ATOM 6318 N PRO B 205 -38.396-10.254-84.3461.0041.48 B

ATOM 6319 CD PRO B 205 -39.704-10.553-83.748 1.0041.24 B

ATOM 6320 CA PRO B 205 -38.192 -8.805-84.4561.0041.26 B

ATOM 6321 CB PRO B 205 -39.530 -8.221-83.998 1.0039.86 B _„„

567

ATOM 6322 CG PRO B 205 -40.498 -9.343-84.155 1.0040.42 B

ATOM 6323 C PRO B 205 -37.060 -8.369 -83.5361.0042.21 B

ATOM 6324 O PRO B 205 -36.700 -7.195-83.4891.0042.36 B

ATOM 6325 N THR B 206 -36.501 -9.335-82.8121.0043.25 B ATOM 6326 CA THR B 206- -35.449 -9.075-8-1.838 1.0043.96 B

ATOM 6327 CB THRB 206 -35.962 -9395-80.42J 1.0044.54 B

ATOM 6328 OGl THRB 206 -36.676-10.641-80.453 1.0045.16 B '

ATOM 6329 CG2THRB206 -36.881 -8.278-79.9161.0044.18 B

ATOM 6330 C THRB 206 -34.163 -9.85« -82.045 1.0044.19 B ATOM 6331 O THRB 206 -33.227 -9.719-81.258 1.0043.98 B

ATOM 6332. N PHE B207 -34.112-10.672-8-3.0951.0044.62 B

ATOM 6333 CA JHE B 207 -32.933-11.497-83.3721.0.044.82 B

ATOM 6334 CB PHE B 207 -32.946-11.968-84.8241.0042.35 B

ATOM 6335 CG PHE B 207 -31.886-12.978-85.1361.0040.27 B ATOM 6336 CDl PHE B 207 -31.778-14.144-84388 1.0040.59 B

ATOM 6337 CD2 PHE B 207 -31.00.1 -12.777 -86.183 1.0039.60 B

ATOM 6338 CEl PHE B 207 -30.801 -15.104 -84.6821.0039.44 B

ATOM 6339 CE2PHEB207 -30.019-13.730-86.4861.0038.94 B

ATOM 6340 CZ PHE B 207 -29.923 -14,896-85.731 1.003834 B ATOM 634-1 C PHE B 207 -31.580-10.834-83.075 1.0045.77 B

ATOM 6342 O PHE B 207 -30.750-11.387-82.343 1.0046.99 B

ATOM 6343 N GLU B 208- -31.349 -9.658-83.6461.0045.60 B-

ATOM -6344 CA GLU B 208 -30,083—8.972-83.4.091.00:46.28 B

ATOM_z6345 CB GLUB208 -29,980--7.719~~-8'4:2771.0047.16 B ATOM 6346-CG GLU B 20S- -=29.333— 7.964--85.ό3_61.-0G-48J31 B

ATOM^" 634.7 CD-GLUΕ 208- -2-9.476 -6.77-8-86371 1.0048.23 ~B-

ATOM 6348 OEl GLU B 208 -28:510 -5.995 -86.700 1J1O:4^;8:T5 B

ATOM 6349 OE2GLUB208 -30.571 -6.625-87.161 1.0047:56 B

ATOM 6350 C GLU B 208 -29.853 -8.600-81.951 1.0046.25 B ATOM 6351 O GLUB 208 -28.741 -8.710-81.4301.0045.65 B

ATOM 6352 N ASP B 209 -30.913 -8.157-81.294 1.0046.78 B

ATOM 6353 CA ASP B 209 -30.803 -7.778-79.898 1.0046.91 B

ATOM 6354 CB ASP B 209 -32.045 -6.997-79.445 1.0047.71 B

ATOM 6355 CG ASP B 209 -31.967 -5.521-79-7941.0048.68 B _β,_o

JDO

ATOM 6356 ODl ASP B 209 -32.934 -4.786-79.493 1.0050.57 B

ATOM 6357 OD2 ASP B 209 -30.940 -5.090-80.3601.0048.29 B

ATOM 6358 C ASP B 209 -30.630 -9.020-79.045 1.0045.51 B

ATOM 63590 ASP B 209 -29.870 -9.015-78.086 1.0045.60 B ATOM 6360 N ASP B 210 -31.327 -10.090 -79.403 1.0043.59 B

ATOM 6361 CA ASP B 210 -31.224-11.308-78.6321.0043.00 B

ATOM 6362 CB ASP B 210 -32.205-12.372-79.132 1.0043.70 B

ATOM 6363 CG ASP B 210 -33.666-11.992-78.893 1.0045.10 B

ATOM 6364 ODl ASP B 210 -33.941 -11.270 -77.9071.0044.76 B ATOM 6365 ΘD2 ASP B 210 -34.541-12.431-79.6801.0045.07 B

ATOM 6366 £ ASP B 210 -29:817-11.861-78-6741.0042.00 B

ATOM 636-7 O ASP- B 210 -29.335-12.405-77.6871.0042.44 B

ATOM 6368 N LEUB 211 -29.123-11.734-79.795 1.0040.90 B

ATOM 6369 CA LEUB 211 -27.776-12.293-79.7791.0040.09 B ATOM -6370 CB- LEUB 211 -27.282 -1-2.735 -81.133 1.004CL20 B

ATOM 6371 CG LEU B 211 -28.142-13.664-81.965 1.0039.22 B

ATOM 6372 CDl LEU B 211 -28.473-12.861-83.203 1.0038.56 B

ATOM 6373 CD2LEUB211 -27.407-14.946-82.3441.0036.79 B

ATOM 6374 C LEUB 211 -26.773 -11.343 -79.246 LOG 39.98 B ATOM 6375 O LEUB 211 -25.596-11.682-79.112 1.0039-82 -B

ATOM 6376 N GLUB 212 ^27.202-10.127-7-8.985 1.0039.88 B-

ATOM 63-77 CA-GLU-B-212 -26.265 -9.204 -78.405 tOO 40.12- B

ATOM .6378 CB GLU B 212 -26J730 -7.778-78^5821.0041.3.7 B-

-ATOM 6379- GG ULU B 212 -25,^07 -6r824 -77.930 1.0044.34 B ATOM 6380 CD GLU W2Ω -25A83 -5.719 -78.858 lvθ.0.46.60 B

ATOM 63-81 OEl GLUB 212 -24.509 -5.856-79.623 LOO 49:47 B

ATOM 6382 ΘE2 GLU B 212 -26.23-1 -4.729=78.8441.0047.59 B

ATOM 6383. C GLU B 212 -26.290 -9.607-76.915 1.0039.79 B

ATOM 6384 O GLU B 212 -25.227 -9.936-76.345 1.0040.12 B ATOM 6385. N HIS B 213 -27.489 -9.636-76.3241.0038.47 B

ATOM 6386 CA HIS B 213 -27.668 -9.999-74.9081.0036.84 B

ATOM 6387 CB HIS B 213 -29.158-10.308-74.5371.0040.07 B

ATOM 6388 CG HIS B 213 -30.095 -9.130-74.6561.0044.14 B

ATOM 6389 CD2HISB213 -31.349 -8.917-74.173 1.0045.30 B ^

ATOM 6390 NDl fflS B 213 -29.791 -8.014-75.4091.0046.29 B

ATOM 6391 GEl fflS B 213 -30.809 -7.167-75.388 1.0046.56 B

ATOM 6392 NE2 HIS B 213 -31.768 -7.690-74.645 1.0046.93 B

ATOM 6393 C HIS B 213 -26.896-11.294-74.7091.0034.16 B ATOM 63940 HIS B 213 -26.105-11.466-73.7901.0035,.OO B

ATOM 6395- N LEUB 214 -27.174-12.229-75.593 1.0030.34 B

ATOM 6396 CA LEU B 214 -26.565-13.534-75.494 1.0027.26 B

ATOM 6397 CB LEUB 214 -27.157-14.442-76.5341.0026.67 B

ATOM 63W CG LEU B 214 -27.690-15.662-75.8271.0026.70 B ATOM 6399 CDl LEU B 214 -29.207-15.707-76.003 1.0025.47 B

ATOM 640O CD2LEUB214 -27.016-16.894-76.4061.0026.59 B

ATOM 6401 -C LEU B 214 -25.06343.651-75.5581.0026.14 B

ATOM 6402 O LEUB 214 -24.480-14.606-75.045 1.0025.57 B

ATOM 6403 N TYRB 215 -24.420 -12.690 -7.6-1991.0025.39 B ATOM 6404 CA TYRB 215 -22.975-12.755-76.3001.0023.37 B

ATOM 6405 CB TYRB 215 -22.458-1-2.022-77.549 1.0020.12 B

ATOM 6406 CG TYR B 215 -20.967-12.171-77.681- 1.0015.82 B

ATOM 6407 CDl TYRB 215 -20.388-13.423-77.918 -1.0013.74 B

ATOM 640& CElTYRB 215 -19.016 -13.586 -77.8S41.0011.58 B ATOM 6409 CD2 TYRB 215 -20.132 -11.094 -77.432 LOO 11.92 B

ATOM 6410 CE2TYRB2L5 -18.771-11.249-77.39« 1.0010.43 B

ATOM 6411 CZ TYRB 215 -18.217 -L2_492 -77.6161.0010:6& B

ATOM 6412-OH TYRB 215 -16.862 -12.640 -77.512 1.0011.97 B

ATOM 6413 C TYK=B_215 -22.472 -12.111 -75:0271.002233_ B ATOM 64L4 O TYRB^~215 -21.394 -12.439 -74.5371:0021.S4: B.

ATOM 6415 -N GLN-B-2-16 -23:305-11.216-74.4591.0022.93 B

ATOM 6416 CA GLN-B 2T6 -23.013-10:506-73.236-1.0023.05. B

ATOM 6417-CB GLNB216 -24.288 -9.869-72.683 1.0024.47 B

ATOM 6418 CG GLN B 216 -24.694 -8.629-73.371 1.0029.21 B ATOM 6419 CD GLNB 216 -23.672 -7.544-73.125 1.0031.52 B

ATOM 6420 OEl GLNB 216 -23.969 -6.519-72.4921.0032.54 B

ATOM 6421 NE2GLNB216 -22.440 -7.777-73.5891.0032.32 B

ATOM 6422 C GLN B 216 -22.537-11.486-72.1861.0020.90 B

ATOM 6423 O GLNB 216 -21.512-11.327-71.5091.0018.45 B _m

ATOM 6424 N GLNB 217 -23.372-12.495-72.0661.0018.20 B

ATOM 6425 CA GLN B 217 -23.186-13.557-71.1371.0018.07 B

ATOM 6426 CB GLNB 217 -24.346-14.448-71.213 1.0019.08 B

ATOM 6427 CG GLN-B 217 -25.546-13.797-70.874 LOO 21.85 B ATOM 642S- CD^" GLN-B 217 -26.368 -14.817 -70.709 1.0024.02 B ATOM 6429 OEl GLNΕ-217 -26.240 -15.971 -70.4521.0024.02 B ATOM 6430 NE2 GLN B 217 -27.827 -14.435 -70.861 1.0026.55 B

ATOM 6431 C GLNB 217 -22.005-14.424-71.3471.0019.05 B

ATOM 6432 O- GLN-B 217 -21.313-14.837-70.425 1.0019:42 B ATOM 6433 N LEUB 2T8 -21.785-14.765-72.5891.0017.95 B

ATOM 6434 CA LEU B218 -26:668 -15.627 -72.827- 1.0016.83 B-

ATOM -6433 CB LEU B 218 -20.950-1.6:496-74.0171.0020.95 B

ATOM 6436 CG LEU B 218 -21.933-17.635-73.8321.0023.66 B

ATOM 6437 CDlLEUB 218 -22.683 -17.766 -75.1291.0025.79 B ATOM -6438 CD2 LEU B^"218 -21-.210 -18.928-73.4901.0023.92 B

ATOM 6439 C LEUB 218 -19,335-14.971-73.023 1.0014.88 B

ATOM 6440 O LEUB 218 -18.317-15.659-73.052 1.0012.83 B

ATOM 6441 N GLUB 219 -19.323-13-/650-73.163 1.0012.74 B

ATOM 6442 CA GLU B ^"219 -18.059-12.962-73.4091.0011.14 B ATOM 6443 CB GLU B 219 -18.253-11.457-73.613 1,0011.46 B

ATOM €444 CG GLU B-2Ϊ9 -16.928 -10.714 -73.697 LOO 13.01 B

ATOM 6445 CD GLU B 219 -17.Q64 -9.301-74.2241.0015.27 B

ATOM 6446- OEl GLUB 219 -18.083- -8,633-73.940 1.0017.73 B

ATOM. =6447 OE2 GLU B 219 -16.132 -8.844 -74913, 1.0015.96 B- ATOM 6448-C -GLU B-219 -17:023-13.200-72.3381.0010.84 B

ATOM 6449^~-O GLU B 219 -15τ819 -13.297 -72.6321.007764 B

ATOM 6450-N PRO-R 22Θ -17.471-13.289-71.0691.0011.14 B

ATOM 6451 CD -PRO B 220 -18.814-12.986-70.5421.Θ09.06 B

ATOM 6452 CA PROB 220 -16321 -13.523 -69.9771.0010.37 B ATOM 6453 CB PRO B 220 -17.420-13.603-68.7561.0011.84 B

ATOM 6454 CG PRO B 220 -18318-12.637-69.105 1.0011.86 B

ATOM 6455 C PRO B 220 -15.757-14.809-70.213 1.0010.20 B

ATOM 6456 O PRO B 220 -14338-14.865-70.0691.0010.04 B

ATOM 6457 N LEU B 221 -16301-15.837-703961.0011.06 B ^

ATOM 6458 CA LEUB 221 -15.928-17.140-70.891 1.0011.29 B

ATOM 6459 CB LEU B 221 -16.962-18.032-71.5771.0012.13 B

ATOM 6460 CG LEU B 221 -17.794-19.007-70.742 1.0012.68 B

ATOM 646J CDl LEU B 221 -16.854-19.997-70.055 1.0012.92 B ATOM 6462 CD2 LEUB 221 -18.638-1-8:249 -69r7171.0012.45 B

ATOM 6463 C LEUB 221 -14.742 -16.996.-71.81T 1.0012.10 B

ATOM 6464 O LEUB 221 -13.650-17.484-71.5061.0011.43 B

ATOM 6465 N TYRB 222 -14.961-16.319-72.9381.0012.11 B

ATOM 6466 CA TYR B 222 -13.901 -16.148 -73τ921 1.0013.44 B ATOM 6467 CB TYR B 222 -14.42445.401-75.1781.0012.98 B

ATOM 6468 CG TYR B 222 -13.427-15.374-7O091.0Q-1L47 B

ATOM 6469 CDl TYR- B.222 -12.9S2 -16.564 -76.891 1.0011.72 B-

ATOM 6470 CEl TYRB 222 -11.970-16.570-77.8361.0012.48 B

ATOM 6471 CD2 TYR B 222 -12.839-14.187-76.716 1.0011.90 B ATOM 6472 CE2 TYR B 222 -11.821 -14.183 -77.670 LOO 13.30 B

ATOM 6473 CZ TYR B 222 -11.395-15.374-78.2201.0014-21 B

ATOM 6474 OH TYR B 222 -10.406-15.359-79.1721.0017.95 B

ATOM 6475 C TYR B 222 -12.708-15.415-73.3171.0014.03 B

ATOM 6476 O TYR B 222 -11.579-15.914-73.3421.001333 B ATOM 6477 N LEU B 223 -12.963-14.239-72.755 1.0014.96 B

ATOM 6478 CA LEU B 223 -11.895 -13,452 -7-2.166 r.00-ϊό.21 B

ATOM 6479 CB LEUJB 223 -12.474 -12.242 -71.4361.00^""1334- B

ATOM- 6480 CG LEU B 223 -13.298-11.279-72.2861.0016.71 B-

ATOM 648-1 CDl LEU B 223 -13:619 -100949 -71.4661.0017.34 B - ATOM 6482 CD2 LEU B 223 -12.521-10.8-91-73.5281.0017.55 B

ATOM 6483 C LEUB 223 -11.026 -I4.Z66 -71.2121.0017.64 B

ATOM 6484 O LEUB-223 -9.812-14:056 -71.L4S 1.0018.70 B

ATOM 6485 N ASN B 224 -11.627-15.198 -70.477^"1.OO 17.39 B-

ATOM 6486 CA ASN B 224 -10.837-15.978-69.545 1.0018.77 B ATOM 6487 CB ASN B 224 -11.710-16.587-68.433 1.0019.76 B

ATOM 6488 CG ASN B 224 -11.891-15.643-67.2481.0019.57 B

ATOM 6489 ODl ASN B 224 -10.916-15.242-66.602 1.0018.55 B

ATOM 6490 ND2 ASN B 224 -13.135-15.284-66.963 1.0019.52 B

ATOM 6491 C ASN B 224 -10.032-17.041-70.2571.0018.99 B ATOM 6492 O ASN B 224 -8.874-17.259-69.9061.0020.08 B

ATOM 6493 N LEU B 225 -10.622-17.699-71.2561.0018.45 B

ATOM 6494 CA LEU B 225 -9.884-18.721-72.0091.0017.59 B

ATOM 6495 CB LEU B 225 -10.819-19.471-72.958 1.0017.30 B ATOM 6496 CG LEU B 225 -10.192-20.561-73.8361.0017.72 B

ATOM 6497 CDl LEUB 225 -9.536-21.643-72.9771.0018.51 B

ATOM 6498 CD2 LEU B 225 -11.282-21.165-74.7191.0018.71 B

ATOM 6499 C LEU B 225 -8.771-18.013-72.8061.0016.90 B

ATOM 6500 O LEU^*B225 -7.641-18.498-72.9271.001-7.32 B ATOM 6501 K HIS B 226 -9.106-16.830-73.3041.0015.29 B

ATOM 6502 CA. HIS B 226 -8.172 -16.027 -74.0791.0015.22 B

ATOM 6503 CB HIS B 226 -8.919-14.817-74.6801.0015.00- B

ATOM 6504 CG HIS B 226 -8.036-13.862-75.422 1.0015.43 B

ATOM 6505 CD2 HIS B 226 -7:748 -13.754 -76.7421.0015.27 B ATOM 6506 NDl HIS B 226 -7340 -12.851 -74.7891.0013.51 B

ATOM 6507 CEl HIS B 226 -6.670-12.158-75.689 1.0013.29 B

ATOM 6508 NE2 HIS B 226 -6.902 -12.684 -76.880 LOO 16.17 B

ATOM 6509 C HIS B 226 -6.938 -15.572 -73.2971.0015.65 B

ATOM 6510 O HIS B 226 -5.805-15.732-73.7501.0015.10 B ATOM 6511 N ALA B 227 -7.144-14.998-72.1171.0017.13 B

ATOM 6512 CA ALA B 227 -5.996 -14.549 -71.318 1.0015τ6T B

ATOM 6513 CB ALA B-227 -6.449 -13.826-70J0861.0016.26 B-

ATOM 6514 C ALA-B 227 -5rl72 -1-5.751 -70^20-1,0014.61 B

ATOM^" 6515 O ALA B 227 -3.932=-15.7ϊ3^:-70.9391.0013^4 B ATOM -6516 N PHE-B^228 -5.870-16.-829-70:572 1.0014.34 B^~

ATOM 6517 CA PHE Br2-2S- -5.206-18,066-70.180 1.00-15,84 ^"B

ATOM 6518 CB TEE ΕTZZ8 -6.217 -19.149-=69:804 l.OΘ 15.31 B^"

ATOM 6519 CG PHE B 228 -5.577 -20.421 -69.288 k0016.22 B

ATOM 6520 CDl PHE B 228 -4.905 -20.434 -68.077 LOO 14.89 B - ATOM 6521 CD2PHEB228 -5.629-21.597-70.0321.0016.73 B

ATOM 6522 CEl PHE B 228 -4.298 -21.583 -67.6201.0015.36 B

ATOM 6523 CE2 PHE B 228 -5.023-22.750-69.582 1.0016.71 B

ATOM 6524 CZ PHE B 228 -4.353-22.741-68.3701.0016.55 B

ATOM 6525 C PHE B 228 -4.296-18.616-71.263 1.0017.76 B ATOM 6526 O PHE B 228 -3.155-19.001-70.981 1.0018.70 B

ATOM 6527 N VAL B 229 -4.803-18.665-72.4961.0018.16 B

ATOM 6528 CA VAL B 229 -4.019-19.176-73.611 1.0018.59 B

ATOM 6529 CB VAL B 229 -4.896-19.400-74.8601.0019.83 B

ATOM 6530 CGl VAL B 229 -4.040-19.871-76.0271.0018.80 B

ATOM 6531 CG2 VAL B 229^" -5.960-20.441-74.544 1.0023.48 B

ATOM 6532 C VAL B 229 -2.881 -18.235 -73.9641.0018.04 B

ATOM 6533 O VAL B 229 -1.759-18.682-74.2261.0020.10 B

ATOM 6534 N ARG B 2JO -3.158-16.935-73.9551.0016.34 B

ATOM 6533 CA ARG B 230 -2.140-15.956-74.301 1.0017.18 B

ATOM- 6536 CB ARG B 230 -2.685-14.542-74.1271.0016.61 B

ATOM 6537 CG- ARG B 230 -1.678 -13.444 -74.4521.0017.64 B

ATOM 6538 CD ARG B 230 -2.349-12.073-74.431 1.0018.71 B

ATOM 6539 NE ARG B 230 -3.018-11.839-73,159 1.0019.52 B

ATOM 6540 CZ ARG B 230 -3.861-10.841-72.922 1.0020.33. B

ATOM 6541 NHΪ ARG B 230 -4.149 -9.963 -73.868 1,0022.46 B

ATOM 6542 NH2 ARG B 230 .4.443 -10.742 -71.743 1.0019.77 B

ATOM 6543 C ARG B 230 -0.908-16.160-73.4401.0018.14 B

ATOM 6544 O ARG B 230 0.218-16.260-73.941 1.0018.49 B

ATOM 6545 N ARGB-231 -1.130-16.239-72.136 1.0019.03 B

ATOM 6546 CA ARG B 231 -0.03-8-16.445-71.2071.0019.37 B

ATOM -6547 CB ARG B 23 f -0.60-146:620 -69.7921.0σ21.35 B

ATOM- 6548 CG ARG-B-231 0.188-17.169-68.-7701.0023.22 B-

ATOM 6549 CD-ARG-B^'23-1 T.524 -16.213-68.488 XOO 24.50- B

ATOM 6550 ME-ARG=B 231 L335 -15.53-7 -6-7.2141.-0026.31 B

AT=OM 655 L CZ TtRG B 231 2277 -15.457 -66.27&I7G0-26.79 B

ATOM 6552 NHl ARG B 231 -2.020 -14.825^~65.148^" 1.Θ0-26.51 B

ATOM 6553 NH2ARGB231 3.468-16.006-66.462 1.0026.80 B

ATOM 6554 C ARG-B 231 0.765 -17.678 -71.63010018.96 B

ATOM 6555 O ARG B 231 1985-17.726-714791.0017.36 B

ATOM 6556 N ALA B 232 0.070-18.670-72.1741.0019.59 B

ATOM 6557 CA ALA B 232 0.730-19.889-72.601 10020.26 B

ATOM 6558 CB ALA B 232 -0.296-20.976-72.89410019.44 B

ATOM 6559 C ALA B 232 1555-19.596-73.831 1.0020.99 B ATOM 6560 O ALA B 232 2.707-20.037-73.9361.0021.80 B

ATOM 6561 N LEU B 233 0.980-18.838-74.7601.0020.47 B

ATOM 6562 CA LEU B 233 1.711-18.520-75.975 1.0020.68 B

ATOM 6563 CB LEU B 233 0.789-17.826-76.9821.0021.01 B

ATOM 6564 CG. LEU B-233 -0.334 -L8.688 -77.5841.0020.85 B

ATOM 6565 CDl LEUB 233 -1.283-17.814-78.391 1.0021.34 B

ATOM 6566 CD2LEUB233 0.264-19.776-78.4601.0020.42 B

ATOM 6567 C LEU B 233 2.934-17.663-75.648 1.0020.09 B

ATOM 6568 O LEU B233 3.980-17.785-76.282 1.0018.44 B

ATOM 6569 N HIS B 234 2.806-16:823-74.6261.0021.56 B

ATOM 6570 CA HIS B 234 3.903-15.950-74.201 1.0023.36 B

ATOM 6571 CB HIS B 234 3.439-15.025-73.0771.0024.97 B

ATOM 6572 CG HIS B 234 4.519-14.132-72.5371.0028.52 B

ATOM 6573 CD2 HIS B 234 4.781-12.817-72.744 1.0028.46 B

ATOM 6574 NDl HIS B 234 5.507-14.586-71.688 1.0030.18 B

ATOM 6575 CEl HIS B 234 6.329-13.590-71398 1.0029.27 B

ATOM 6576 NE2 HISB 234 5.911-12.507-72.0271.0027.64 B

ATOM 6577 C HIS B 234 5.046-16.807-73.7271.0023.67 B

ATOM 6578 O HI-SB 234 6.217-16.577-74.0271.0023.50 B

ATOM 6579 N ARG B 235 4.662-17.808-72.9641.0025.07 B

ATOM 6580 CA ARG B 235 5.614 -18.768 -72.462 1.0027.61 B

ATOM 6581 CB ARG B 235 4.876-19.956-71.902 1.0030.88 B

ATOM 6582 CG ARGB 235 5.435-20.48.8-70.6431.0034.45 B

ATOM- 6583 GD .ARG-JB 235 4.614-19.90-7-69:527 L003K12 B

ATOM 6584 NE ARG B-235 3.264 -20._4.7« -69^445 1.003SrIO. B

ATOM 6585 CZ ARG-R235 2.510-20.422-68.351 00-38759 B

ATOM 65S6 NHl ARG B 235 2.993-19^.829-67.273 1.0037.24 B

ATOM 6587 NH2ARGB235 L280 -20.9-35 -68.335 1.0038.30 B

ATOM 6588 C ARG B-235 6.458 -19.298 -73_^613 1.0028.03 B

ATOM 6589 O ARGB 235 7.646-19.114-73.6701.0027.05 B

ATOM 6590 N ARGB 236 5.773-19.939-74.5521.0028.58 B

ATOM 6591 CA ARG B 236 6.531-20.531-75.608 1.0027.36 B

ATOM 6592 CB ARG B 236 5.796-21.815-76.1291.0027.53 B

ATOM 6593 CG ARG B 236 5.127-21.731-77.5271.0028.73 B ATOM 6594 CD ARG B 236 5.845-22.770-78.402 1.0030.00 B

ATOM 6595 NE ARG B 236 5.552-24.177-78.062 1.0029.70 B

ATOM 6596 CZ ARG B 236 6.359-25.203-78.321 1.0030.63 B

ATOM 6597 NHl ARG B 236 7.520-24.956-78.901 1.0030.51 B

5- ATOM 6598 NH2 ARG B 236 5.983 -26.4.66 -73.0701.0031.03 B

ATOM -6599 C ARG B 236 7.120-19.645-76.6881.0025.85 B

ATOM 6600 O ARG B 236 8.260-19.846-77.0881.0025.97 B

ATOM 6601 N TYRB 237 6.430-18.613-77.1401.0024.00 B

ATOM 6602 CA TYRB 237 7.037-17.740-78.183 1.ΘO^"22.64 B

10 ATOM 6603 CB TYRB 237 5.990-17.192-79.185 1.0018.72 B

ATOM 6604 CG TYRB-237 5.274 -18.2S6 -79.918 1.0017.26 B

ATOM 6605 CDl TYR B 237 3.939-18.557-79.654 IJOO 16.39 B

ATOM 6606 CEl TYRB 237 3.264-19.582-80.3161.0016.88 B

ATOM 66Θ7 CD2TYRB237 5.935 -19,071 -50.8681.0016.55 B

15 ATOM 6608 CE2TYRB23-7 5.274 -20.101 -.81.5391.0015.04 B

ATOM 6609 CZ TYRB23-7 3.936 -20.353 -81.258 1.0016.86 B

ATOM 6610 OH TYR B 237 3.259 -21.374 -8L898 1.0016.32 B

ATOM 6611 C TYRB 237 7.895-16.572.-77.6971.0023.11 B

ATOM 6612 O TYRB 237 8.721-16.005-7-8.425 1.0021.90 B

20 ATOM 6613 N GLYB 238 7.722-16.192-76.451 1.0024.38 B

ATOM 661.4- CA GLY B 238 8.579-15.138-75.951 1.0025.83 B

ATQM- 6615 C GLYB238 7.985-13.759-75:94-71.0027.22 -B

ATOM 6616 O GLYB_'238 7.060-13.429-76.6921.002&58 B

ATΘM- 6612 N ASP B 239 8:554-12.93i-75::091 kθO 28.53 B

25. ATOM 6618 CA ASP B 239 8.062 -11.579 -74:9271.0029.26 B,

ATOM -6619 t:B ASPB 239 %867 -10.860 -73.860 1.ΘΘ3Θ.I8 B

ATOM 6620 CG ASP B 239 8:072 -9.761-71.236170030.99 B

ATOM 6621 ODl ASP B 239 6.869-10.006-72.9621.003L5S- B

ATOM 6622 OD2 ASP B 239 8.633 -8.665-73.0391.0033.53 B

30 ATOM 6623 C ASP B 239 7.989-10.706-76.1671.0028.64 B

ATOM 6624 O ASP B 239 7.264 -9.706-76.2191.0028.11 B

ATOM 6625 N ARG B 240 8.719-11.102-77.1851.0029.08 B

ATOM 6626 CA ARG B 240 8.734-10.329-78.3921.0028.62 B

ATOM 6627 CB ARG B 240 9.887-10.729-79.2271.0031.33 B ATOM 6628 CG ARG B 240 10.011 -9.839-80.363 1.0034.98 B

ATOM 6629 CD ARG B 240 11.341-10.063-80.9071.0038.10 B

ATOM 6630 NE ARG B 240 11.737 -8.960-81.7491.0041.91 B

ATOM- 6631 CZ ARG B 240 11.743 -9.004-83,0691.0043.55 B

ATOM -6632 NHl ARG B 240 11.371-10.109-83.699 1.0043.42 B

ATOM 6633 NH2ARGB240 12.129^" -7.933 -83.743 1.0044.43 B

ATOM 6634 C ARG B 240 7.515-10.452-79.2501.0028.00 B

ATOM 6635 O ARG B 240 7.068 -9.484-79.8561.0028.21 B

ATOM 6636 ^"N TYR B 241 6.984 -M .657 -79.3251.0026.84 B

ATOM 6637 CA TYRB 241 5.815-11.855-80.1521.0026.80 B

ATOM- 6638 CB TYETB 24-1 5:950-13.126-80.9421.0027.51 B

ATOM 6639 CGTYRB-241 7.095-13:027-81.8591.0029.95 B

ATOM 6640 CDl TYRB 241 8.148-13.920-81.7491.0032.02 B

ATOM 6641 CEl TYRB 241 9.249-13.817-82.5491.00.33.87 B

ATOM 6642 Cm TYR B- 241 7.155-12.008-82.8101.0031.15^" B

ATOM 6643 CE2TYRB241 8.247-11.874-83.6251.0032.46 B

ATOM 6644 CZ TYRB 241 9.298-12.791-83.493 1.0034.00 B

ATOM 6645 OH TYRB 241 10.411-12.717-84.294 1.0035.19 B

ATOM 6646 C TYRB 241 4.476-11.860-79.521 1.0025.75 B

ATOM 6647 O TYRB 241 3.467-11.776-80.2041.0025.47 B

ATOM -6648 N- ILE B 242 4.447 -11.994 -78.216 1.0024.90 B

ATOM 6649 CA ILE B 242 3.173 -1Z000 -77.5481.0022.87 B

-ATOM 6650 CB ELEB 242 2.995-13.295-76.759 1.0022.48 B

ATOM 6651 CG2 ELE B 242 1.6.73-13.273-76.043 1.0ΪL23.33 B

^~ ATOM 6652 CGMLEB 242 3.O65-14.496-77.700 1.0023.31 B

ATOM 6653 CDHLE-B-242 1.835 -14.-668--78.5681.0024.81 B

ATOM 6654 C ILE B 242 3.11Φ-107812 -7-6.610 h0022.5S B

ATOM 6655 O ILE B 242 4.103-10.485-75.9571.0022.63 B

ATOM 6656 N ASN B 243 1.984-10.118-76.5771.0022.41 B

ATOM 6657 CA ASN B 243 1.855 -9.001-75.643 1.0022.53 B

ATOM 6658 CB ASN B 243 1.441 -7.714-76.343 1.0024.30 B

ATOM 6659 CG ASN B 243 1.295 -6.555-75.372 1.0026.51 B

ATOM 6660 ODl ASN B 243 0.616 -6.668-74.353 1.0028.88 B

ATOM 6661 ND2ASNB243 1.932 -5.437-75.6821.0026.05 B ATOM 6662 C ASN B 243 0.789 -9.396 -74.631 1.0021.44 B

ATOM 6663 O ASN B 243 -0.375 -9.562 -74.977 1.0021.88 B

ATOM 6664 N LEU B 244 1.202 -9.552 -73.379 1.00 20.62 B

ATOM 6665 CA LEU B 244 0.306 -9.974 -72.298 1.00 19.32 B.

ATOM 6666 CB LEU B 244 1.106 -10.147^71.014 1.00 17,79 B

ATOM 6667 CG- LEU B 244 1.989 -11.389 -71.-Θ91 1.00 16.76 B

ATOM 6668 CDl LEU B 244 3.015 -11.374 -69.988 1.00 17.60 B

ATOM 6669 CD2 LEUB 244 1.103 -12.623 -71.020 1.00 13.89 B

ATOM 6670 C LEU B- 244- -O783O -9T022 -72.064 h00 17.78 B

ATOM 6671 O LEU B 244 -1.780 -9.312 -71.345 1.00 14.85 B

ATOM 6672 N AKG 3 245 -0:722 -7.870 -72:699 1.00-18.36 B

ATOM- 6673 CA ARG B 245 -1.732 -6.844 -72.565 1.00 19.43 B

ATOM 6674 CB ARG B 245 -1.136 -5.647 -71.857 1.00 22.45 B

ATOM 6675 CG ARG B 245 -.1.653 -5.473 -70.445 1.00 25.43 B

ATOM 6676 CD ARG B 245 -0.50? -3.5-98-69.490 1.00 27.69 B

ATOM 6677 NE ARG B 245 0.598- -4.723 -69.878 1.00 31.94 B

ATOM 6678 CZ ARG B 245 β;923 -3.599 -69.244 1.00 35.05 B

ATOM 6679 NHl ARG B 245 0.210 -3.235 -68.193 1.00 37.17 B

ATOM 6680 NH2 ARG B 245 1.963 -2.852 -69.641 1.00 35.20 B

ATOM 6681 C ARG B 245 -2.316 -6.416 -73.907 1.00 19.13 B

ATOM 6682 O ARGB 245 -3.158 -5.522.-73.995- 1.00 18.43 B

ATOM- 6683 N GLY B 246^" -1.856 -7.O70^' -74.962 1.00 18:76_ B

ATOM 6684-CA GLYfl-246 -.2.336 -6.747 -76.287- 1.00 16.52 B

ATOM 6685 C -GLY B IM -3.080 -7.919 -76.868 1.00 14fiθ B

ATOM 6686 O GLY B-246- -3.239 -8.-91-8 -76.183 1.00 13.35 B

ATOM 6687 N PROB 247 -3.562 -7.826 -78-.1T9 -1.00 14.07 B.

A-TΘM^" 6688^" CD PRO B-247 -3.552 -6.661 -79.014 1.00 14.51 B

ATOM 66S9 CA PRO B 247 -4.287 -8.931 -78.741- 1.00 13.48 B

ATOM 6690. CB PRO B 247 -4.998 -8.261 -79.896 1.00 13.37 B

ATOM 6691 CG PRO B 247 -4.022 -7.263 -80.318 1.00 14.35 B

ATOM 6692 C PRO B 247 -3.320 -10.004 -79.200 1.00 12.95 B

ATOM 6693 O PRO B 247 -2.110 -9.784 -79.238 1.00 13.18 B

ATOM 6694 N ILE B 248 -3.849 -11.172 -79.535 1.00 13.49 B

ATOM 6695 CA ELE B 248 -2.999 -12.277 -79.969 1.00 13.02 B „„

D /O

ATOM 6696 CB ILE B 248 -3.612-13.637-79.5641.0011.84 B

ATOM 6697 CG2 ELE B 248 -2.636 -14.766 -79.8781.0011.81 B

ATOM 6698 CGl ELE B 248 -3.950-13.641-78.075 1.0010.79 B

ATOM 6699 CDl ELE B 248 -4.563-14.941-77.618 1.0013.73 B ATOM 6700 C ELE B 248 -2.75Θ -12.306 -81.4771.0012.55 B

ATOM 6701 O ELEB248 -3.634-11.993 -82.269 1.0.012.59^" B

ATOM 6702 N PRO B 249 -1.540-12.650-81.889 1.0012.56 B

ATOM 6703 CD PRO B 249 -0.314 -12.748 -81.079 1.0013.21 B

ATOM 6704 CA PRO B 249 -1.229 -12.725 -83.313 1.0013^41 B^" ATOM 6705 CB PRO B 249 0.240-13.131-83.301 1.0014.23 B

ATOM 6706 CG PRO B 249 0.760-12:434-82.073 1.001-3:06 B-

ATOM 6707 C -PRO^ 249 -2.133 -15.8M -83,935 1.0013.90 B

ATOM 6708 O PRO B 249 -2.071-14.978-83.535 1.0013.46 B

ATOM 6709 N ALA B 250 -2.958-13.426-84.9091.0013.89 B ATOM 6710 CA ALA B 250 -3.908-14.330-85.575 1.0012.68 Ti

ATOM 6711 CB ALA B 250 -4,620-13.581-86.6731.0012.05 B

ATOM 6712 C ALA B 250 -3.428 -15.6S2 -86.1241.0012.63 B

ATOM 6713 O ALA B 250 -4.252-16.510-86.5071.0013.95 B

ATOM 6714 N HIS B 251 -2.128-15.934-86.161 1.0011.34 B ATOM 6715 CA HIS B 251 -1.659-17.214-86.675 1.0011.82 B

ATOM 6716 CB HIS B 251 -0.618 -16.962-8TJ7371.001139- B

ATOM 6717 CG HIS B-251 0.63I -16.358 -87.197 LW-IO^ B-

ATOM 6718 CB2HIS-B-251 1.913-16.793-87.212-1.0012.66 B

ATOM 6719-ND1HΪSB251 0.641 -15.151 =86.539 HQO 11.04 B ATOM- 6720 CEl HIS B 251 1.877 -14.865 -86.170-1,00-12.14 B

ATOM -6321 NE2 HIS B 251 2.669 -157844-86.5S81.0013.23 B

ATOM ^722 C HISB.251 -1.046-18:180-85.646 U-ΘO LULL B

ATOM 67230 HIS B 251 -0.337-19.124-86.021 1.0013.83 B

ATOM 6724 N LEU B 252 -1.312 -L7.972 -84.362 1.0013.60 B ATOM 6725 CA LEU B 252 -0.715-18.824-83.334 1.0012.98 B

ATOM 6726 CB LEU B 252 -0.060-17.960-82.2741.0014.71 B

ATOM 6727 CG LEU B 252 0.913-16.965-82.885 1.0018.36 B

ATOM 6728 CDl LEU B 252 1.446-16.043-81.812 1.0021.21 B

ATOM 6729 CD2 LEU B 252 2.045-17.725-83.5561.0020.12 B ^

ATOM 6730 C LEU B 252 -1.690-19.760-82.6591.0011.60 B

ATOM 6731 O LEU B 252 -1.303-20.655-81.925 1.0010.92 B

ATOM 6732 N LEUB 253 -2.964-19.538-82.9101.0011.25 B

ATOM 6733 CA LEU B 253 -3.996 -20.353 -82J 181.0011.56 B ATOM 6734 CB LEU B 253^{^} -5.320-19.611-82.3021.0.011.93 B

ATOM 6735^""CG LEU B 253 -5.635 -18.492 -81.3001.0012.S9 B

ATOM 6736 CDl LEU B 253 -5.248-18.888-79.898 1.0011.42 B

ATOM 6737 CD2 LEUB 253 -4.868-17.272-81.674 1.0013.79 B

ATOM 6738 C LEU B 253 -47239-21.687-82.995 1.0014.25 B ATOM 6739 O LEU B 253 -5.326-22.241-82.8791.0014.17 B

ATOM 6740 N GLY B 254 -3.256-22.198-83.7241.0018.48 B

ATOM 6741 CA GLY B.254 -3τ416 -23.488 -84.3871.002L29 B

ATOM 6742 C GLY B 254 -4.531-23.652-85.4291.0023.12 B

ATOM 6743 O GLY B 254 -5.013 -24.766-85.6491.0024.72 B ATOM 6744 N ASP B 255 -4.956-22.564-86.0781.0022.79 B

ATOM 6745 CA ASP B 25-5 -5.974=22.614-87.1001.0022.67 B

ATOM 6746 CB ASP B 255 -7.346-22.691-86.4581.0023-78- B

ATOM 6747 -CG ASP B 255 -8.463 -22.544 -87.461 1.0026.28 B

ATOM 6748 ODl ASP B 255 -8.459-21.560-88.2251.0027.66 B ATOM 6749 OD2ASPB255 -9.360-23.410-87.4861.0028.48 TJ

ATOM 6750 C ASP B 255 -5.873-21.354-87.943 LOO 22.89 B

ATOM 6751 O ASP B 255 -57741 -20.260 -87.4071.00-2439 B

ATOM 6752 N MET B 25.6 -5.936-21.521-89.260 L00J21.81 -B ATOM^" 6753 CA -MET B 256 -5.84tL20.422 -90.2171.0020.15 B ATOM= 6754 CB MET B 256 -6,325 -20.902 -91.59S- 1.00 ±8.38 B

ATOM 6755 ^CG ^"MET B 256 -6rl:ό8~*9:904 -92.743- 1.0013.23- BT

ATOM 6756 SD MET B 256^' -4.4^'69^"-19^ 18 -92.8671.00- 11.20 -B

ATOM 6757 CE MET B 256 -3.616-20.795 -93.3121.00 L0.75 B

ATOM 6758 C MET B 256 -6.630-19.188-89.795 1.0020.67 B ATOM 6759 O MET B 256 -6.15L -18.058 -89.9161.0020.75 B

ATOM 6760 N TRP B 257 -7.833-19.408-89.285 1.0020.68 B

ATOM 6761 CA TRP B 257 -8.700-18.310-88.870 1.0023.25 B

ATOM 6762 CB TRP B 257 -10.099-18.559-89.4321.0024.87 B

ATOM 6763 CG TRP B 257 -10.076-18.769-90.8971.0029.08 B ___.

ATOM 6764 CD2 TRP B 257 -9.895 -20.012 -91.581 1.0031.15 B

ATOM 6765 CE2 TRP B 257 -9.888-19.731-92.9621.0030.49 B

ATOM 6766 CE3 TRP B 257 -9.735-21.339-91.161 1.0032.60 B

ATOM 6767 CDl TRP B 257 -10.169-17.811-91.8671.0030.27 B ATOM 6768 NEl TRP B 257 -10.058-18.381-93.1071.0030.44 B

ATOM 6769 CZ2 TRP B 257 -9.731 -^~20.724 -93.9241.0030.74 B

ATOM 6770 CZ3 TRP B 257 -9.576 -22.330 -92.1271.0031.07 B

ATOM 6771 CH2 TRP B 257 -9.576-22.014-93.4891.0029.77 B

ATOM 6772 C TRP B 257 -8.780 -1^"8.059-87.35O 1.002227 B ATOM 6773 O TRP B 257 -9.453-17.125-86.9091.0020.13 B

ATOM 6774 N ALAB 258 -8:093 -18.S94 -86.569 LOO 21.98 B

ATOM 6775 CA ALA B 258 -8.083-18.770-85.109 1.0022766 B

ATOM 6776 CB ALA B 258 -7.559-17.410-84.703 1.0022.90 B

ATOM 6777 C ALA B 258 -9.50-7- -18.923 -84.6-141.0022.92 B ATOM 6778 O ALA B 258 -9.967-18.171-83.7591.0022.21 B

ATOM 6779 N GLN B 259 -L0.208 -19.906 -85.1501.0023.74 B

ATOM 6780 CA GLN B 259 -11.5.97 -20.082 -84.7801.0024.99 B

ATOM 6781 CB GLN B 259 -12.413-20.193-86.051 1.0027.46 B

ATOM 6782 CG GLN B 259 -11.927-21.252-87.011 1.0030.23 B ATOM- 6783 CD GLNJB 259 -12.926-21.431-88.135 1.0033.53 B

ATOM 6784 OEl GLN B 259 -12.628-21.181=89.3171.0037.36 B

ATOM 6785 NE2 GLN-B-259 -14.140-21.835-87.773 1.0031^66 B

ATOM 6786 C GLN B 259^" -Ilτ891 -21.269-83:872 i.OQ-24.57 B_

AXGM 6-787 O GLN B 259 -13:010 -21.460 -85.3771.0823.16 B ATQM -6788 N SERB 260_ -Iτ9-r861 -22:06-9 -83.6671.0(12447 -B

ATOM 6789 CA ^ER B26Q -10.945 -23.235 -.82.821 1.0024.3:1- B

ATOM 6790- CB SER B 260 -11:429-24.445-83.586-1:00.23.79^" B

ATOM 6791 OG .SERB 260- -10.378 -25.389 -83.5901.0026.36 B

ATOM 6792 C SER B 260 -9.514-23.460-82.405 1.0Θ 24.77 B ATOM 6793 O SER B 260 -8.634-23.604-83.2591.0023.68 B

ATOM 6794 N TRPB 261 -9.286-23.514-81.0961.0026.50 B

ATOM 6795 CA TRP B 261 -7.930-23.677-80.5881.0027,42 B

ATOM 6796 CB TRPB 261 -7.674-22.640-79.4851.0030.21 B

ATOM 6797 CG TRP B 261 -8.061-21.222-79.861 1.0032.14 B ATOM 6798 CD2 TRP B 261 -8.051-20.067-79.005 1.0033.52 B

ATOM 6799 CE2 TRP B 261 -8.458-18.964-79.789 1.0033.15 B

ATOM 6800 CE3 TRP B 261 -7.733-19.858-77.653 1.0033.19 B

ATOM 6801 CDl TRP B 261 -8.463-20.781-81.0841.0033.09 B ATOM 6802 NEl TRPB 261. -8.704 -19-.429 -81.051 1.0034.15 B

ATOM 6803 CZ2TRPB261 -8.559-17.669-79.2701.0032.64 ^"B

ATOM 6804 CZ3 TRP B 261 -7.833-18.568-77.136 1.0032.58 B

ATOM 6805 CH2 TRP B 261 -8.244-17.490-77.9461.0032.02 B

ATOM 6806 C TRP B 261 -7.486-25.053-80.0891.0025.61 B ATOM -6S07 O TRP B 261 -6.380-25.181-79.558 1.0026.20 B

ATOM 6808 N ALAB 262 -8309 -26.077 -80.2801.0023.69 B

ATOM 6809 CA ALA B 262 -7.962-22.413-79:805 1.0023.00 B

ATOM 6810 CB ALA B 262 -9.075-28.389-80.119 1.0022.45 B

ATOM 6811 C ALA B 262 -6.660-27.958-80.3471.0023.14 B ATOM 6812 O ALAB 262 -6.09S -28.867 -79.767 LOO 22.92 B

ATOM.6813 N ASN ff 263 -6.172-27.405-81.448 1.0025.32 B

ATOM 6814 CA- ASN B 263 -4.939-27.897-82.065 1.0026.60 B

ATOM 6815 CB ASNB 263. -4.872-27.438-83.513 1.0029.50 B-

ATOM 6816 CG ASN B 263 -5.644-28.330-84.4191.0032.87 B ATOM 6817 ODl ASN B 263 -5.287 -29.490 -84JI91 1.0035.83 B

ATOM 6818 ND2 ASN B 263 -6.729 -27.819 -84.9871.0035.39^' B

ATOM .6819 C ASN B-263 -3.732 -27.397 -8Ϊ.3S6- 1.0026.63 B

ATOM 6820 O ASN B 263 -2.594 -27.549-81.793 LOO 27.39- B

ATOM 6S21 N ILEB 264 .-37975-26.813-80.2181.0027:40' B ATOM 6822 CA DDE B 264 -2.876 -26.223 -79.533 JJ3029rL2 B

ATOM 6823 CBT ILE B 264 -2.974-24.768-79.813 1.-00:29.27 B-

ATOM 6824 CG2 ILE B 264- -3.215-23.977-78.5341.0028:89 B

ATOM .6825 CGl ILE B 264 -1.766 -24.347 -8G.601 LOO 28.67 B

ATOM 6826 CDl ELE B 264 -1335-23.018-80.138 1.0029.89 B ATOM 6827 C ILE B 264 -2.981 -26.545 -78.065 1.0029.77 B

ATOM 6828 O ILE B 264 -2.479-25.867-77.178 1.0030.81 B

ATOM 6829 N TYRB 265 -3.675-27.626-77.8381.0031.10 B

ATOM 6830 CA TYR B 265 -3.910-28.097-76.521 1.0031.78 B

ATOM 6831 CB TYR B 265 -4.879-29.249-76.6781.0032.08 B ATOM 6832 CG TYR B 265 -5.365-29.848-75.430 1.0032.73 B

ATOM 6833 CDl TYRB 265 -6.583-29.457-74.860 1.0032.99 B

ATOM 6834 CEl TYR B 265 -7.064-30.092-73.725 1.0032.96 B

ATOM 6835 CD2TYRB265 -4.639-30.869-74.849 1.0033.82 B ATOM 6836 CE2 TYR B 265 -5.092-31.506-73.7301.0033.62 B

ATOM 6837 CZ TYRB 265 -6.307-31.121-73.167 1.0033.58 B

ATOM 6838 OH TYR B 265 -6.715-31.752-72.022 1.0033.44 B

ATOM 6839 C TYRB 265 -2.584-28.469-75.8661.0032.56 B

ATOM 6840 O TYRB 265 -2.297-28.048-74.7541.0032.26 B ATOM 6841 N ASP B 266 -1.739- -29.201 -76.572 1.0033.82 B

AT-OM^" 6842 CA ASP B 266 -0.460-29.576-75.985 1.0035.82 B

ATOM ^'6:843 CB ASP B 266 0.400 -30.377- -76=9821.0037.81 B.

ATOM 6844 CG ASP B 266 0.768-29.582-78.2161.0039.78 B

ATOM 6845 ODl ASP B 266 -0.151 -29.155 -78.952 1.00-42.13 B ATOM 6846 OD2 ASP B 266 1S81 -29.384 -78.448 1.0039.57 B

ATOM 6847 C ASP B 266 0.350-28.394-75.4461.0035.70 B

ATOM 6848 O ASP B 266 1.433-28.606-74.930 1.003-531 B

ATOM 6849 N MET B 267 -0.159-27.164-75.54-9 LOO 36.45 B

ATOM 6850 CA MET B 267 0.569-25.994-75.031 1.0036.70 B ATOM 6851 CB MET B 267 0.783 -24.943 -76.1091.0036.90 B

ATOM 6852 GG MET B 267 1.411-25.456-77.368 1.0038.15 B:

ATOM 6853 SD METB 267 L83J -24.049 -78.3421,00-39,80 B ATOM- 6854 CE MET B 267 3334-24.283-78.451 1.OJO 37.08 B

ATOM 6855 C MET-B 267 -0.1-86^25329-73.893 1-.B&3&.72 B AΪΘM, 6856 O MET B 267 0.363-24.467-73.2061.0036.35 B

ArTΘNfc -6857 ^~N VAt R 268 -1.431-25.723 -73.7041.003636 B-

ATOM 6858 CA VAE B 268 -2.231- -25.13S -72.6541.0037.48 B ATOM-6859 CB VAL B 268 -3389-24.352-73.242 1.0037.13 B

ATOM 6860 CGl VAL B 268 -2.855 -23.191 -74.048 1.0036.73 B ATOM 6861 CG2 VAL B 268 -4.232-25.258-74.106 1.0037.03 B

ATOM 6862 C VAL B 268 -2.780-26.148-71.668 1.0038.86 B

ATOM 6863 O VAL B 268 -3.132-25.784-70.552 1.0039.42 B

ATOM 6864 N ALA B 269 -2.860-27.412-72.073 1.0041.04 B

ATOM 6865 CA ALA B 269 -3.368-28.462-71.1881.0042.17 B ATOM 6866 CB ALA B 269 -2.908-29.849-71.6691.0041.94 B

ATOM 6867 C ALA B 269 -2.891-28.217-69.7571.0042.97 B

ATOM 6868 O ALA B 269 -1.681-28.243-69.4671.0042.61 B

ATOM 6869 N PRO B 270 -3.846-27.953-68.851 1.0043.04 B

ATOM- 3870 .CD PRO B 270 -5.277-27.819-69.178 1.0042.25 B

ATOM 6871 CA ^"PRO B 270 -3.617 -27.689 -67.430 1.0044.61 B

ATOM 6872 CB PRO B 270 -5.021-27.725-66.855 1.0043.46 B

ATOM 6873 CG PRO B 270 -5.821-27.118-67.962 1.0042.58 B

ATOM 6874 C -PROB 270 -2;689 -28.693 -66.7571.0046.80 R

ATOM 6875 O PRO B 270 -1.598-28.335-66.315 1.0048.42 B

ATOM 6876- N -PHE B 271 -37119-29.949-66:6841.0048.07 B

ATOM- 6877 CA PHEB 271 -2.310-30.980-66.048 1.0049.74 B

ATOM 6878 CB PHE B 271 -3.128-31.679-64.9701.0049.89 B

ATOM 6879 CG PHE B 271 -3.841-30.724-64.063 1.0049.89 B

ATOM 6880 CDl PHE F 271 -5.216-30.590-64.128 1.0049.45 B

ATOM 6881 CD2 PHE B 27-1 -3.129-29.918-63.1801.0049.05 B

ATOM 6882 CEl PHE B 271 -5.875-29.668-63.3301.0048.97 B

ATOM 6883 CE2 PHE B 271 -3.779-28.994-62.383 1.0049.05 B

ATOM 6884 CZ PHE B 271 -5.157-28.868-62.4571.0048.75 B

ATOM 6885 C PHE B 271 -1.789-31.982-67.0571.0051.31 B

ATOM- 6&86 O PHEB27Ϊ -2.463 -32:955 -67.396- 1.0051.25 B

ATOM 6SSTTSf PRO B 272 -0:567-31.745^~-6.7.553 1.0052.83 B-

ATOM 6U& CD PRO-B 272 CL246 -30:578 -67.180 1.0052τ95 B

ATOM 6M9-CA PRO B 272 0.143-32.561-68,536 1.0055.-07 B

ATOM 6890 CB PRO B 272 1.471 -3 L823 -68.696 1.0054.48 B

ATOM -689-1 CG PRO B 272 1.122 -30τ413 -6&380^"!.00-53.29 B

ATOM -6892 C-JEIRO-B 272 0.347-33:991 -68.0721.00-57.26 B

ATOM 6893- O PROB 272 0.323-34.925-68.8821.0058.30 B

ATOM 6894 N ASP B 273 0.560-34.140-66.7661.0059.48 B

ATOM 6895 CA ASP B 273 0.785-35.441-66.1381.0062.15 B

ATOM 6896 CB ASP B 273 0.619-35.317-64.6171.0063.50 B

ATOM 6897 CG ASP B 273 1.395-36.383-63.851 1.0065.13 B

ATOM 6898 ODl ASP B 273 2.642-36.402-63.9481.0066.36 B

ATOM 6899 OD2ASPB273 0.756-37.197-63.148 1.0065.64 B ATOM 6900 C ASP B 273 -0.189-36.468-66.708 1.0063.25 B

ATOM 6901 O ASP B 273 0.219 -37.471 -67.2971.0064.12 B

ATOM 6902 N ALA B 274 -1.482-36.205-66.539 1.0064.05 B

ATOM 6903 CA ALA B 274 -2.508-37.097-67.079 1.0064.93 B

ATOM 6904 CB AXAB 274 -3v966 -36.630-66.6621.0065.41 B

ATOM 6905 C ALA B 274- -2.343-37.068-68,5911.0064.95 B

ATOM 6906 O ALA B 274 -2.085-36.013-69.175 1.0065.82 B

ATOM 6907 N PRO B 275 -2.467-38.229-69.2341.0064.36 B

ATOM 6908 CD PRO B 275 -2.163 -39.480 -68.509^" 1.0063.M B

ATOM 6909 CA PRO B 275 -2.336 -38.404 -70.6861.0064.32 B

ATOM 6910 CB PRO B 275 -1-462 -39.648--70.787170064722 -B

ATOM 6911 CG PRO B^: 275 -L912 -40.455 -69.612 1.0063.57 B

ATOM 6912 C PRO B 275 -3.648-38.544-71.4771.0064.02 B

ATOM 6913 O PRO B 275 -4.747-38.598 -70.9101.0063.67 B

ATOM 6914 N ALA B 277 -6.428 -37.769 -74.633^" 1.00-62.63 B

ATOM 6915 CA ALA B 277 -6.023-36.338-74.7921.0064.37 B

ATOM 6916 CB ALA_B 277 -4.526-36,258-74.835 1.0063.05 B

ATOM 69-17 C ALA B 277 -6.693-35.940-76.1341.0065.64 B

ATOM 6918 O ALA B 277 -7.580 -35 JOO -76.1951.0066.45 B

ATOM 6919 N ASP B 278 -6.210-36.515-77.2541.0066.30 B

ATOM 6920 CA ASP B 278 -7.066 -36.9.07 -78.3^71.0067.06 B

ATOM 6921 GB ASP B 278 -7.135-J5τS91 -79.5191.00-67.17 B

ATOM 6922 CG-ASPB-27S -8.493-35.867-80.1-861.0067-15- B-

ATOM- 6923- ODl ASP B 278- -8.988^34.789-80.476 1.00-67.04 B

ATOM 6924 OD2ASPB278 -97181 -36-1855-80:441 1.0066.54- B.

ATOM- 6925 C ASPB27S -6.799-38.221-79.028 1.00-67.70- B

ATOM 6926 Θ ASPB^'278 -5,6S9-38.707-r79.028 1.00-68:28 B

ATOM 6927 N VAL-B 279 -7.823 -38.764 -79T6671.0067.4L B

ATOM 6928 CA VALJB 279- -7.957-40.216-79.652 1.00.66.62 B

ATOM 6929 CB VAL B 279 -9.436-40.647-79.643 1.0066.52 B

ATOM 6930 CGl VAL B 279 -9.810-41.292-80.9681.0066.53 B

ATOM 6931 CG2 VAL B 279 -9.7Q7 -41.594 -78.485 1.0066.62 B

ATOM 6932 C VAL B 279 -7.267-40.835-80.863 1.0066.08 B

ATOM 6933 O VAL B 279 -7.614-41.935-81.293 1.0066.85 B -_a.

ATOM 6934 N THR B 280 -6.288-40.119-81.4081.0064.96 B

ATOM 6935 CA THRB 280 -6.032-40.141-82.843 1.0064.19 B

ATOM 6936 CB THRB 280 -5.902-38.707-83.3891.0063.59 B

ATOM 6937 OGl THR B 280 -7.119-38.331-84.045 1.0062.69 B ATOM 6938 CG2 THRB 280- -4.871-38,655-84.506 1.00-62.14 B-

ATOM 6939 C THR B 280 -4.772-40.938-83.1601.0064.54 B.

ATOM 6940 O THR B 280 -4.788-41.832-84.0061.0064.46 B

ATOM 6941 N SERB 281 -3.682-40.610-82.473 1.0065.12 B

ATOM 6942 CA SERB 281 -2.464-41.358-82.596 1.0064:97 B ATOM 6943 CB SERB 281 -1.487 -40.863 -81.544 LOO 64.60 B

ATOM 6944 OG SERB 281 -2.073-39.887-80.717 1.00-64.32 B

ATOM 6945 C SERB 281 -2.7,91 ^{■ '}-42.767-82.325 1.O0-64.96 B

ATOM 69460 SERB 281 -1.998-43.670-82.5091.0065.04 B

ATOM 6947 N THRB 282 -3.998-42.908-81.842 l.OO 65.22 -B ATOM 6948 CA- THR B 282 -4.545 -44.154 -«1.434 1.0065.54 B

ATOM 6949 CB THRB 282 -5.004-43.869-80.022 1.0065.02 B

ATOM 6950 OGl THRB 282 -3.852 -43.901 -79.J821.0064.68 B

ATOM 6951 CG2THRB282 -6.028-44.776-79.563 1.0064.32 B

ATOM 6952 C THR B 282 -5.602-44.594-82.461 1.0065.82 B ATOM 6953 O THR B 282 -6.013 -45.758 -82.5161.0066.47 B

ATOM : 6954- N MET B 283 -6.006-43.654-83.303 1.08-65.90 B

ATOM 6955 CA MET-B 2«3 -6.929-43.960-84.371 1.0065.65 ^"B^"

ATOM 6SS6 CB-METB 283 -7.615 -42.698 -84.908 LOO 65.47 B

ATOM 6957 CG METJB 283 -8.694-42.117-84.048 L90^5.33 B^" ATOM 6958 SD-MET B 283 -9.489-40.679-84.7861.0067:34^" B

ATOM 6959 CE ME-T=^283 -11.160 -41.271 ^8-5.033^~L0065J1-6 B

ATOM -69-60 C^" METΕ 285 -5.962 -44^8-85.401- 1.0066,10 B

ATOM 6961 O MET B 283 -6.077-45.619-85.840 1.0065.37 B-

ATOM 6962 N ALAJB 284 -4.974-43.667-85.7481.00-66.59 B ATOM 6963 CA ALA B 284 -3.980-44.062-86.7491.0066.93 B

ATOM 6964 CB ALA B 284 -2.850-43.014-86.8601.0066.63 B

ATOM 6965 C ALA B 284 -3.364-45.426-86.471 1.0067.17 B

ATOM 6966 O ALA B 284 -3.020-46.164-87.3861.0067.44 B

ATOM 6967 N ALA B 285 -3.223-45.782-85.2071.0067.51 B ^

JOO

ATOM 6968 CA ALA B 285 -2.602-47.068-84.9581.0067.99 B

ATOM 6969 CB ALA B 285 -1.794-46.997-83.675 1.0067.56 B

ATOM 6970 C ALA B 285 -3.437-48.344-84.9741.0068.23 B

ATOM 6971 O ALA B 285 -2.889-49.418-84.815 1.0068.47 B ATOM 6972 N GLN B 286 -4.738-48.235-85.1661.0068.29 B

ATOM 6973 CA GLNB 286 -5.568 -49.410 -85.203 1.0069.02 B

ATOM 6974 CB GLN B 286 -6.451-49.461-83.9621.0069.18 B

ATOM 6975 CG GLN B 286 -7.917-49.546-84.2091.0069.65 B

ATOM 6976 CD GLN B 286 -8.661-49.383-82.9421.0069.48 B ATOM 6977 OEl GLN B 286 -9.880-49.500-82.9081.0069.14 B

ATOM 6978 NEZGLNB 286 -7.931-49.103-81.8681.0069.41 B

ATOM 6979 C GLN B 286 -6.297-49.560-86.525 10069.58 B

ATOM 6980 O GLNB 286 -7.443-49.974-86.595 1.0070.27 B

ATOM 6981 N GLY B 287 -5.653-49.029-87.5541.0069.72 B ATOM 6982 CA GLY B 287 -6.202-49.104-88.893 1.0069.09 B

ATOM 6983 C GLY B 287 -7.507-48.358-89.1101.0068.90 B

ATOM 6984 O GLY B 287 -8.473-48.943-89.5851.0068.74 B

ATOM 6985 N TRP B 288 -7.604-47.100-88.693 1.0068.81 B

ATOM 6986 CA TRP B 288 -8.840-46363-88.9571.0069.20 B ATOM 6987 CB TRP B 288 -8.952-45.284-87.8941.0070.10 B

ATOM 6988 CG TRP B 288 -9.755-45.817-86.718 1.0070.41 B

ATOM 6989 CD2 TRP B 288. -11.015-45.324-86.282 1.0070.51 B

ATOM 6990 CE2TRPΕ2S8 -Ii .450 -46.139 -85.206 1.0070.70. B

ATOM 6991 CE3TRPB28E- -11.825 -44,265 -8J6L6971.00-70.69 ^"B ATOM 6952 CDl TRPB-288 -9.464 -46.£00=85.9071.0070.63- B

ATOM -6993 NEl TRP-B-288 -10.488-47.097-849971.0071.13 B

ATOM 6994 CZ2TRPB288 -12.672-457914-84.543 1.0070.66 B-

ATOM 6995 CZ3 TRP B 288 -13.033-44.038-86.0441.0070.57 B'

ATOM 6996 CH2 TRP B 288 -13.445-44.858-84.976 1.0070.38 B ATOM 6997 C TRP B 288 -8.958-45.875-90.4061.0069.11 B

ATOM 6998 O TRP B 288 -8.000-45.453-91.0491.0069.26 B

ATOM 6999 N ASN B 289 -10.166-46.002-90.9021.0068.07 B

ATOM 7000 CA ASN B 289 -10.480-45.815-92.2871.0066.51 B

ATOM 7001 CB ASN B 289 -11.234-47.064-92.6101.0066.71 B .„

JO/

ATOM 7002 CG ASN B 289 -11.114-47.469-94.003 1.0066.51 B

ATOM 7003 ODl ASN B 289 -12.121-47.704-94.658 1.0065.95 B

ATOM 7004 ND2 ASN B 289 -9.881-47.617-94.481 1.0066.97 B

ATOM 7005 C ASN B 289 -11.320-44.633-92.685 1.0065.62 B ATOM 7006. O ASN B 289 -12.372-44.427-92.1001.0065.09 B

ATOM 7007 N ALA B 290 -10.936-43.888-93.7091.0064.68 B

ATOM 7008 CA ALA B 290 -11.797-42.781-94.081 1.0064.60 B

ATOM 7009 CB ALAB 290 -11.403-42.230-95.425 1.0064.19 B

ATOM 7010 C ALA B 290 -13.255-43.291-94.1071.0064.69 B ATOM 7011 O ALA B 290 -147181 -42.567-93.736 1.0064.69 B

ATOM 7012 N THR B 291 -13.455-44.553-94.480 1.0064.31 B

ATOM 7013 CA THR B-291 -14.805-45.102-94.548 1,0063.95 B

ATOM 7014 CB THRB 291 -14.873-46.197-95.625 1.0064.10 B

ATOM 7015 OGl THRB 291 -14.087-45.801-96.755 1.0064.73 B - ATOM 7016 CG2 THR B 291 -16.283 -46.383^" -96.088 LOG 63.89 B-

ATOM 7017 C THRB 291 -15.287-45.656-93.2061.0063.30 B

ATOM 7018 O THRB 291 -16.482-45.577-92.8821.0063.74 B

ATOM 7019 N ALA B 292 -14.359-46.208-92.426 1.0061.75 B

ATOM 7020 CA ALA B 292 -14 J03 -46.758 -91.118 1.0059.86 B ATOM 7021 CB ALA B 292 -13.483 -47.444 -9Q.4901.0059.78 B

ATOM 7022 C ALA B 292 -15.196-45.61-8-9-0.233 1.0058.45 B

ATOM 7023 O ALA B 292 -16.102-45.798-89:415 1.0Q 57.55 B

ATOM 7024 N MET B 293- -14.601 -44.441 -90.4T21.0.056.89- B

ATOM 7025- _CA- MET B 293 -14.983 -4-3.263-89.6411700-55.42 B ATOM 7026 CB MET B 293 -14,U2_=42.G44 -90.023 l.αθ:54.65 B-

AT-OM 7027 CG MET B-293 -12rό57~-42.138 -89:5201700:54.28 B

ATOM 702-8- SD- MET-B-293 -11.525-40:813-89.993 IJOO 53.64 B

ATOM 7029 CE MET B 293 -12.135-39.497-88.954 1.0054.97 B

ATOM 7030 C MET B 293 -16.463-42.954-89.8561.0054.83- B ATOM 7031 O METB293 -17.217-42.816-88.898 1.0054.28 B

ATOM 7032 N PHE B 294 -16.888-42.871-91.112 1.0055.02 B

ATOM 7033 CA PHE B 294 -18.287-42.575-91.413 1.0055.00 B

ATOM 7034 CB PHE B 294 -18.493-42.360-92.911 1.0053.03 B

ATOM 7035 CG PHE B 294 -17.970-41.053-93.4151.0051.02 B _coo

-too

ATOM 7036 CDl PHE B 294 -16.624 -40.897 -93.712 1.0050.73 B

ATOM 7037 CD2 PHE B 294 -18.825-39.969-93.575 1.0050.22 B

ATOM 7038 CEl PHE B 294 -16.129 -39.670 -94.161 1.0050.93 B

ATOM 7039 CE2 PHE B 294 -18.347-38.741-94.021 1.0050.43 B ATOM 7040 CZ PHE B 294 -16.993 ,38.591 -94.316- 1.0051.21 B

ATGM 7041 C PHE B 294 -19.235-43.668-90.958 1.0055.86 B

ATOM 7042 O PHE B 294 -20.437-43.424-90.795 1.0055.64 B

ATOM 7043 N ALA B 295 -18.700-44.873-90.767 1.0056.45 B

ATOM 7044 CA ALA B 295 -19.511-46.012-90.333 1.0057.05 B ATOM 7045 CB ALA B 295 -18.930-47.309-90.888 1.0056.83 B

ATOM 7046 C ALA-B 295 -19.602-46.074-88.818 1.0056.93 B

ATOM 7047 O ALA B 295 -20.398 -46.82? -88.256.1.0057.50 B

ATOM 7048 N VAL B 296 -18.768-45.275-88.159 1.0056.86 B

ATOM 7049 CA VAL B 296 -18.752-45.185-86.704 1.0055.23 B ATOM 7050 CB VAL-B 296 -17.388 -44J597 -86.180 1.0055.07 B

ATOM 7051 CGl VALB 296 -17:501-44.319-84.724 1.0055.02 B

ATOM 7052 CG2 VALB 296 -16.332-45-776-86.376 1.0054.49 B

ATOM 7053 C VAL B 296 -19.800-44.148-83.352 1.0054.53 B

ATOM 7054 O VAL B 296 -20.538-44.280-85.381 1.0053.86 B ATOM 7055 N ALA B 297 -19.854-43.105-87.165 1.0054.40 B

ATOM 7056 CA ALA B 297 -20.826^" -42.049 -86.963 1.0055.05 B

ATOM 7057 CB- ALA.B 297 -20:581 -40.911 -87:949 1.0055:52 B

ATOM 7058 C ALA B 297 -22.179 -42.675 -87.226 LOO 55.26 B

AgEOM- 7059 O ALA-B 29Z -23..J.73 -423ό7^8&557 1.0054.88- -B- ATOM 7060 N GLU B 298 =22.222 -43 Λ67-8S.211 1.0055.7-8 B

ATOM 7061 CA GLU B 298 -23.426r-44.339 -88.4944.0056.70 B

ATΘM 7062 -CB GLU B 298 -23.166-45342-89.621 1.0056.92 B

ATOM 7063 CG GLU B 298 -24.088 -46.549 -89.604 LOO 56.79 B

ATOM 7064 CD GLU B 298 -24.714-46.825-90.957 1.0057.86 B ATOM 7065 OEl GLU B 298 -25.817-46.303-91.221 1.0057.18 B

ATOM 7066 OE2GLUB298 -24.102-47.564-91.7571.0056.75 B

ATOM 7067 C GLU B 298 -23.941-45.131-87.299 1.0057.33 B

ATOM 7068 O GLU B 298 -25.109-45.021-86.925 1.0057.07 B

ATOM 7069 N ALA B 299 -23.063-45.930-86.701 1.0057.32 B ATOM 7070 CA ALA B 299 -23.385-46.635-85.4671.0057.22 B

ATOM 7071 CB ALA B 299 -22.095-47.079-84.793 1.0058.06 B

ATOM 7072 C ALA B 299 -24.129-45.834-84.4041.0057.10 B

ATOM 7073 O ALA B 299 -25.147-46.281-83.875 1.0056.95 B AT=OM 7074 N PHE B 300 -23.614-44.647-84.097 1.0056.39 -B

ATΘM 7075 OAv-PHEB 300 -24.132-43.850-82.991 1.0056.19 B-

ATOM 7076 CB PHE B 300 -23.281-42.598-82.7691.0054.76 B

ATOM 7077 CG PHE B 300 -23.490-41.954-81.428 1.0052.57 B

ATOM 7078 CDl PHE B 300 -22.539-42.081-80.4281.0051.83 B ATOM 7079 CD2 PHE B 300 -24.635-41.221-81.1671.0052.47 B

ATOM 7980- CElTHE B 300 -22.728 -4L490 -79.194- 1.0052.24 B

ATOM 7081 CE2 PHE B 300 -24.830-40.627-79.934 1.0052.06 B

ATOM 7082 CZ PHE B 300 -23.875-40.762-78.9461.0052.27 B

ATOM 7083 C PHE B 300 -25.556-43.457-83.367 LOO 56.47 B- ATOM 7084 O PHE B 300 -26.464 -43.505 --82.5361.0057.48 B

ATOM 7085 N PHE B.301 -25.745 -^'43.067 -84.623 1.0056:08 B

ATOM 7086 CA PHE B 301 -27.034-42.568-85.0861.0054.99 B

ATOM 7087 CB PHE B 301 -26.927-42.059-86.524 1.0051.82 B

ATOM 7088 CG PHE B 301 -26.625 -40.591 -«6.6271.0048.59 B ATOM 7089 CDl PHE B 301 -25.325-40.149-86.805 1.0046.62 B

ATOM 7090- CD2 PHE B 301 -27,540 -39.653 -86.5441.00-47.71 B

ATOM 7091 VEl PHEB 301^" -25,043 -3&799 -8.6.898 l.-θθ 45.51 B

JHTOM 7092 CE2.BHEB-301 -27.365-38.302-86.6381.0046.23 B

ATOM 7093 CZ PHE B 301- -2ό_065 -3-7.875 -86.8161:0045,08 B_ ATOM 7094-C PHEB 3X)I -28.109-43.646-84.9901.00^~56:01 B

ATOM 7095- O PJHE B^" 301 -29.228 "43.354 -84.551 r.θJθ-55.37 B

ATOM- 7096^"N THRB 302 -27:760-44.860-85:405 1.0057.60- B

ATOM 7097 CA ΕHR B 302 -28.708-45.968-85.4171.0059.21 B

ATOM 7098 CB THR B 302 -28.134-47.189-86.1871.0059.26 B- ATOM 7099 OGl THRB 302 -26.802-47.470-85.735 1.0059.58 B

ATOM 7100 CG2 THRB 302 -28.109-46.910-87.674 1.0059.80 B

ATOM 7101 C THR B 302 -29.108-46.408-84.014 1.0059.83 B

ATOM 7102 O THRB 302 -30.278-46.707-83.762 1.0059.87 B

ATOM 7103 N SERB 303 -28.134-46.436-83.1071.0059.89 B ₅

ATOM 7104 CA SER B 303 -28.374-46.858-81.733 1.0060.15 B

ATOM 7105 CB SERB 303 -27.077-46.744-80.9221.0060.51 B

ATOM 7106 OG SERB 303 -26.002-47.344-81.631 1.0060.90 B

ATOM 7107 C SERB 303 -29.494-46.053-81.0671.0059.62. B ATOM. 7108 O- SERrB- 3-03 -30.102-467509-80.101 1.0060.33 B

ATOM 710-9 N LEUB.304 -29.755-447860 -81.591 LOO 58/87 B

ATOM 7110 CA LEUB 304 -30.843-44.026-81.095 1.0058.79 B

ATOM 7111 CB LEUB 304 -30.492-42.544-81.2401.0057.66 B

ATOM 7112 CG LEU-B 304 -29.027 -42.169--S1.0091.0056.81 B ATOM^" 7113 CDl LEU B 304 -28.921 -40.840 -8D.2771.0057.06 B

ATOM- 7114 CD2 LEU B 304- -28.3Θ5 -43.267-80.242 1.00-56.23 B

ArT^QM 7115 -C LEUB 304 -32:146 -44.33t)--81-.8261.00:59.74 B

ATOM 71160 LEUB 304 -33.206-43.819-81.4641.0058.82 B

ATOM 7117 N GLUR305 -32.060-45.165-82.8571.0061.39 B ATOM 7118 CA GLUB 305 -33.233-45:546-83.6341.0063.42 B

ATOM 7119 CB GLU B 305 -34.288-46.190-82.7321.0063.64 B

ATOM 7120 CG GLUB 305 -33.979-47.626-82.3421.0062.75 B

ATOM 7121 CD GLUB 305 -35.044-48.229-81.448 1.0062.51 B

ATOM 7122 OEl GLU B 305 -34.762-49.255-80.7941.0061.41 B ATOM 7123 OE2GLUB305 -36.163-47.677-81.398 1.006.1.90 B

ATOM 7124- C GLU B 305 -347271-44.874-84.525 1.0064.50- B

ATOM 7125 O GLETJB 3O5- -35.4-73 -4S.066 -84.3471.0064,61 B

ATOM 7126 N MiA-B 306 -33.798 -44.085-^85.4841.0065.48 B

ATOM 7127. GA ALAB-306 -34.679 -43.455 -86.461 L.00o5.58 B ATOM 7128 CB^' ALA-B-S 06 -36; 1-80-43:455. -86.2141.0066.06 B

ATQM 7T29-C AXA B 306 -34.383 -43τ63T--87:.947 L00-65.21 B

ATOM 7130 O- AEA-B 3ϋ6 -3-5.281 -43.543 -88.783 l.OΘ 66.01 B

ATOM 7131 N SERB307 -33.115 -43.879-SS.265 1.0064.27 B

ATOM 7132 CA SERB 307 -32.690-44,096-89.6441.0062.79 B ATOM 7133 CB SERB 307 -33.163-42.948-90.5381.0061.45 B

ATOM 7134 OG SERB 307 -32.439-42.919-91755 1.0061.25 B

ATOM 7135 C SERB 307 -31.271-44.660-89.6651.0061.99 B

ATOM 7136 O SERB 307 -30.723-45.021-88.6241.0062.33 B

ATOM 7137 N PROB 308 -30.684-44.747-90.8541.0061.13 B ^

ATOM 7138 CD PRO B 308 -31.277-46.066-91.115 1.0060.35 B

ATOM 7139 CA PRO B 308 -29.249-44.727-91.1461.0060.85 B

ATOM 7140 CB PRO B 308 -28.844-46.180-90.8991.0059.86 B

ATOM 7141 CG PRO B 308 -30.076-46.978-91.240 1.0059.97 B ATOM 7142 C PRO B 308 -28.945-44.341-92.591 1.00^,61.32 B

ATOM 7143 O PRO B 308 -29.811-43.806-93.28.41.00-61.99 B

ATOM 7144 N MET B 309 -27.721-44.614-93.033 1.0061.33 B

ATOM 7145 CA MET B 309 -27.263-44.184-94.315 1.0062.09 B

ATOM 7146 CB MET B 309 -25.797 -43.821 -94Λ28 1-θθ 63.t2 B ATOM 7147 CG MET B 309 -25.638-42.765-92.991 1.0663.27 B

ATOM 7148 SD METB 309 -26.037 -4LΘ64 -93.518170063.23 B-

ATOM- 7149 CE METB 309 -27.736-4X001-93.0891.0062:74 B

ATOM 7150 C METB 309 -27.499-44.959-95.5951.0061.92 B

ATOM 7151 O METB 309 -26.699-45.821-95.9641.0062.66 B ATOM 7152 N PRO B 310 -28.554-44.566-96.3621.0061.28: B

ATOM 7153 CD PRO B 310 -29.215-43.254-96.2071.0061.13 B

ATOM 7154 CA PRO B 310 -28.952-45.186-97.64.1 1.-0060.92 B

ATOM 7155 CB PROB 310 -29.770-44.083-98.313 LOO 60.35 B

ATOM 7156 CO PROB 310 -30.406-43.367-97.125 1.0060.30 B ATOM 7157 C PROB 310 -27.740-45.655-98.488 1.0061.27 B

ATOM 7158 O PRO a 310 -26.657 -45.052 -98,470- JL00-60T75 B

ATQM 7159 N PRO B 311 -27.908 -46.752 -99.258^" L.0062.27 B

ATOM 7160- CD PRO B 311 -29J341 -47.677 --99-A05 1.0062.33- B

ATOM 7161 CA-PRO^~B^~311 -26.761-47.223-100:061 1.0062.20 B -AT-ΘM 7162 CB PRO B 3 Ii -27.201 -48.593=100,56-41.Θ061.60 B'

ATΘM- 7163 CG-PROB 311 -28.319-48.994-99:6171.0061.67 -B

ATOM 7164 C PROB311 -26.509 -46.254- IOI. rl92_1.0.061.92 ^"B-

ATOM 7165 O PROB 311 -25.452-46.253-101.8271.0061.30 B

ATOM 7166 N ALAB 312 -27.522-45.438-101.431 1.0061.41 B ATOM 7167 CA ALA B 312 -27.382 -44.4T9-1O2.422 1.0061.52 B

ATOM 7168 CB ALA B 312 -28.497-43.441-102.263 1.0060.45 B

ATOM 7169 C ALA B 312 -26.082-43.793-101.910 1.0062.15 B

ATOM 7170 O ALAB 312 -25.067-43.634-102.6071.0062.15 B

ATOM 7171 N PHE B 313 -26.158-43.452-100.6371.0062.69 B ATOM 7172 CA PHEB 313 -25.087-42.782-99.9221.0062.22 B

ATOM 7173 CB PHEB 313 -25.548-42.559-98.481 1.0063.70 B

ATOM 7174 CG PHEB 313 -24.482-41.999-97.591 1.0065.14 B

ATOM 7175 CDl PHE B 313 -24.541-40.670-97.1771.0065.64 B

5 ATOM 7176 CD2 PHE B 313 -23.411-42.799-97.168 LOO 65.63 -B

ATOM 7177 CEl PHE B 313 -23.556-40.137-96.359 1.0965.44 B

ATOM 7178 CE2 PHE B 313 -22.410-42.282-96.353 1.0065.85 B

ATOM 7179 CZ PHEB 313 -22.483-40.948-95.943 1.0065.80 B

ATOM 7480 C PHE B 313 -23.680-43.354-99.8821.0061.21 B

10 ATOM 7181 O PHE B 313 -22.684-42.633-99.8901.0061.11 B

ATOM 7182 N TRPB-314 -23.607 -44.659 -99.83⁼8 1.0060.77 B

ATOM 7183 CA TRP B 314 -22.337 -45.277 -99.728 LOQ 60.Ϊ0 B

ATOM 7184 CB TRPB 314 -22.586-46.619-99.1071.0061.65 B

ATOM 7185 CG TRPB 314 -22.562-46.389-97.6291.0063.81 B

15 ATOM 7186 CD2 TRP B 3-14 -21.385-46399-96.8541.0064.75 B

ATOM 7187 CE2 TRP B 314 -2L722 -45.985 -95.539 IJ)O 65.09 B

ATOM 7188 GE3 TRP-B 314 -20.056-46.715 -97.148 LOO 65.23 B

ATOM 7189 CDl TRP B 314 -23.587-45.981-96.7821.0063.94 B

ATOM 7190 NEl TRP B 314 -23.075-45.735-95.5161.0064,11 B

20 ATOM 7191 CZ2TRPB314 -20.754-45.887-94.519 1.0065.79 B

ATOM 7192 CZ3 TRP B 314 -19.111-46.619-964571.0065.76 -B

ATOM 7193- CH2 TRPB 314 -19,454-46.207-94.851- LJ)O 65.96 B

ATOM 7194 C TRPB-314 -21.424-45.273-100.928 I.θθ-58v82- B

ATOM 7195 O TRPB 314 -20L223 -45.494-100.8Ω 1.0057.67 B

-25. ATOM 7196- N- ALA-B 3-15- -22.007 -44.961-ie2.073 LOO 58.47 B

ATOM 7497 CA ALAB 315 -21.267-44.825-1-03.3041.Θ0-57.9T B

ATOM 7198 CB ALA^'B-315 -21.531 -46.019-104.246 LOO 57:11 B

ATOM 7199 C ALAB315 -21.686-43.486-103.94-11.005X53 B

ATOM 7200 O ALAB 315 -20,898-42.895-104.631 1.00-57.48 B

30 ATOM 7201 N GLYB 316 -22.895-42.982-103.7071.0057.06 B

ATOM 7202 CA GLYB 316 -23.228-41.715-104.371 1.0057.02 B

ATOM 7203 C GLYB 316 -22.498-40.614-103.6301.0056.83 B

ATOM 7204 O GLYB 316 -22.934-39.483-103.5061.0056.15 B

ATOM 7205 N ALAB 317 -21.358-41.026-103.0981.0056.76 B ATOM 7206 CA ALA B 317 -20.576-40.174-102.215 1.0056.10 B

ATOM 7207 CB ALAB 317 -21.034-40.494-100.851 1.0056.66 B

ATOM 7208 C ALA B 317 -19.040-40.098-102.1561.0055.74 B

ATOM 7209 O ALAB 317 -18.354-41.108-102.1041.0055.43 B

5. ATOM 7210 N METB 318 -18.519-38.875-102.0721.0055.43 B

ATOM 7211 CA METB 318 -17J069 -38.632-101.9581.0054.89 B

ATOM 7212 CB METB 318 -16.676-37.328-102.651 1.0054.72 B

ATOM 7213 CG METB 318 -15.452-37.473-103.5321.0053.70 B

ATOM 7214 SD METB 318 -14.290 -36.071-103.5611.0054.24^" B 0 ATOM 7215 CE MET B 318 -15.343-34.715-103.112 1.0052.78 B

ATOM 7216 C METB 318 -16.692-38.529-100.4741.0054.94 B

ATOM 7217 O METB 318 -17.060-37.566-99.798 1.0055.22 B

ATOM 7218 N LEUB 319 -15.955-39.519-99.9791.0054.59 B

.ATOM 7219 CA LEUB 319 -15^38-39.533-98.5861.0055.29 B 5 ATOM 7220 CB LEUB 319 -16.017-40.811 -97.899 LOO 54.21 B

ATOM 7221 CG LEUB 319 -17.481- -41.194 -98.0941.0054.32 B

ATOM 7222 CDl LEUB 319 -17.743-42.480-973271.0053.87 B

ATOM 7223 CD2 LEU B 319 -18.393-40.074-97.6151.0053.93 B

ATOM 7224 C LEUB319 -14.031-39.444-98.463 1.0056.28 B 0 ATOM 7225 O LEUB 319 -13.502-39.444-97.363 LOO 57.34 B

ATOM 7226 N GLUB 320 -15351 -39367 -99.595 1.0057.16 B

^"ATOM 7227 CA GLU B 320 -11.893-35.299-99.619 LOO 59.09 B

ATOM 7228- CB GLU B-320 -11.332 -40.685 -9Sτ9771.0059.51 B

-ATOM^" 7229 CG GLUB-320^~ -IL.174^' -4-1.613 -98.7641.006UJSl B 5 ATOM 7230 CD GLU-B 320- -1 Iτl 98 -43J21 -99dLO0 k0061.97 B

ATOM 723-1 OE1GLU:B-320 -12.292-43,652-99.409 l.θθ-βL*r B-

ATOM 7232 OE2 GLU B 320 -10.1-22 -43.773 -99:0^~40.1.0IT61.38 B

ATOM 7233 C GLU B-320 -11.474-38.272-100.6741.0060-38 B

ATOM 72340 GLU B 320 -12.296-37.912-1-01.5151.0061.57 B 0 ATOM 7235 N LYS B 321 -10.232-37.778-100.6341.0060.82 B

ATOM 7236 CA LYS B 321 -9.789-36.803-101.6441.0060.77 B

ATOM 7237 CB LYS B 321 -8.608 -35.937-101.1441.0060.22 B

ATOM 7238 CG LYS B 321 -8.001 -34.958-102.1921.0058.93 B

ATOM 7239 CD LYS B 321 -6.977-34.001-101.5641.0058.55 B ₄

ATOM 7240 CE LYS B 321 -6.367 -33.061-102.598 1.00 58.55 B

ATOM 7241 NZ LYS B 321 -5.452 -32.050-101.988 1.00 57.65 B

ATOM 7242 C LYS B 321 -9.365 -37.588-102.864 1.00 61.24 B

ATOM 7243 O LYS B 321 -8.517 -38.477-102.770 1.00 61.39 B ATOM 7244 N PRO B 322 -9.966 -37.283-104.035 1.00 61.25 B

ATOM 7245 CD PRO B 322 -11.161 -36.464-104.278 1.00 61.50 B

ATOM 7246 CA PRO B 322 -9.591 -37.997-105.244 1.00 60.23 B

ATOM 7247 CB PRO B 322 -10.373 -37.298-106.341 1.00 60.24 B

ATOM 7248^{^} CG PRO B 322 -11.619 -36.940-105.648 1.00 60.42 B ATOM 7249 C PRO B 322 -8.096 -37.955-105.412 1.00 59.90 B

ATOM 7250 O PRO B 322 -7.401 -36.940-105.279 1. QO 60.79 B

ATOM 7251 N ALAB 323 -7.748 -39.203-105.659 1:00 59.12 B

ATOM 7252 CA ALA B 323 -6.484 -39.881-105.859 1.00 59.45 B

ATOM 7253 CB ALA B 323 -6.834 -41.335-105.909 1.00 58.67 B ATΘM 7254 C ALA B 323 -5.563 -39.634-1-07.077 1.00 59.76 B

ATOM 7255 O ALA B 323 -4.345 -39.667-107.004 1.00 59.86 B

ATOM 7256 N ASP B 324 -6.246 -39.649-108.206 1.00 6D.05 B

ATOM 7257 CA ASP B 324 -5.782 -39.624-109.593 1.00 59.44 B

ATOM 7258 CB ASP B 324 -7.019 -40.024-110.355 1.0058.86 B ATOM 7259 CG ASP B 324 -8.302 -39.185-110.022 1.0058.77 B

ATOM 7260 ODl ASP B 324 -8.306-38.004-110.422 1.-00 57.93 B

ATOM 7261 -OD2 ASP B 324 -9.312 -39:68&409.44Q 1.00 58:04 .B

ATOM 7262 C ASP B 324 -5.328 -38.357-109.884 1.00-59.14 B

ATOM 7263 0 ASP B.324 -4r364 -37.988-110.749- 1700 59.01 B ATOM 7264 N GLY B 325 -6.373 -37.70440P.it06 hθO 58.86- B

ATOM 726^"5-CA GLYB 325 -6.264 -36.345-1092:14 1.0057.45 B

ATOM 7266 C GLY-B- 325 -7.038 -35.164-109.280 1.00 56.02 B

ATOM 7267 O GLY B 325 -6.366 -34.1-92-109.-140 1.00 55.83 B

ATOM 7268 N ARG B 326 -8.337 -35.196-109.306 1,00 54.37 B ATOM 7269 CA ARG B 326 -9.034 -33.972-109.646 IJOO 53.11 B

ATOM 7270 CB ARG B 326 -10.160 -34.447-110.488 1.00 51.57 B

ATOM 7271 CG ARG B 326 -10.223 -35.929-110.277 1.00 49.38 B

ATOM 7272 CD ARG B 326 -11.601 -36.324-110.109 1.0047.45 B

ATOM 7273 NE ARG B 326 -11.737 -37.743-109.886 1.00 45.09 B ATOM 7274 CZ ARG B 326 -12.829 -38.268-109.366 1.0045.42 B

ATOM 7275 NHl ARG B 326 -13.823 -37.464-109.035 1.0045.31 B

ATOM 7276 NH2 ARG B 326 -12.924 -39.576-109.190 1.0046.40 B

ATOM 7277 C ARG B 326 -9.495 -32.836-108.787 1.00 53.25 B ATOM 7278 O ARG B 326 -10.492 -32.917-108.074 1.00 53.12 B

ATOM 7279 N- GLU B 327 -8.807 -31.717-108.945 1.00 53.06 B

ATOM 7280 CA GLU B 327 -9.151 -30.583-108.130 1.00 53.29 B

ATOM 7281 CB GLU B 327 -8.628 -29.268-108.693 1.00 55.03 B

ATOM 7282 CG GLU B 327 -7.726 -28.689-107.602 1.00 57.64 B ATOM 7283 CD GLU B 327 -6.594 -27.839-108.117 1.00 59.57 B

ATOM 7284 OEl GLUB 327 -6.263 -27.958-109321 LQO 59.77 B

ATOM 7285 OE2 GLU B 327 -6.032 -27.062-107.303 1.00 60.73 B

ATOM 7286 C GLU B 327 -10.632 -30.558-107.809 1.00 52.50 B

ATOM 7287 0 GLU B 327 -11.517 -30.726-10&66B 1.00 51.86 B ATOM 7288 N VAL B 328 -10:868 -30.448-106.508 1.00 51.94 B

ATOM 7289 CA VAL B 328 -12.208 -30.456-105.923 1.00 50.48 B

ATOM 7290 CB VAL B 328 -12.546 -31.842-105.340 1.00 50.24 B

ATOM 7291 CGl VAL B 328 -12.498 -32:887406.406 1.0050.39 B

ATOM 7292 CG2 VAL B 328 -11.546 -32.196-104.253 1.00 49.64 B ATOM 7293 C VAL B 328 -12.348 -29.494-1.04.756 1.0049.47 B

ATOM 7294 O VAL B 328 -11.351 -29.038-104.206 1.0049.69- B

ATOM 7295^" N VAL B 329- -13.594 -29:213-104.375 1.0047.96 B

ATQM 7296 CA VAL B 329 -13.870 -28.343-103.237 1.0047.07 B

ATOM 7297- CB-VAL B 329 -1-5-.29.6--27.758- 1-03.283. 170046.64 B ATOM 7298 CGl VAL B- 329 -15.553 -26.937-1-02.039 1.00 46.75 B

ATOM 7299 GG2 VAEB 329 -15.478 -26,911-1-64:514 LOO 47.01 B

•ATOM 7300 C VAL B 329 -13.781 -29.299-102τθ65 JLOO 46:97 B

ATOM 7301 O VAL B 329 -14.702 -30.061-101.839 1.0046.62 B

ATOM 7302 N CYS B 330 -12.653 -29.283-101.355 1.00 46.87 B ATOM 7303 CA CYS B 330 -12.421 -30.184-100.218 1.00 46.74 B

ATOM 7304 C CYS B 330 -13.221 -29.892 -98.954 1.00 46.65 B

ATOM 7305 O CYS B 330 -13.315 -30.721 -98.040 1.00 46.31 B

ATOM 7306 CB CYS B 330 -10.947 -30.196 -99.845 1.0046.46 B

ATOM 7307 SG CYS B 330 -10.024 -31.588-100.549 1.00 48.65 B ^

ATOM 7308 N HIS B 331 -13.768-28.694-98.881 1.0046.72 B

ATOM 7309 CA HIS B 331 -14.554-28.357-97.731 1.0046.46 B

ATOM 7310 CB HIS B 331 -15.195-27.008-97.913 1.0046.P3 B

ATOM 7311 CG HIS B 331 -15.406-26.300-96.6241.00-47.72 B ATOM 73.12 CD2 HIS B 331 -14.511-25.764-95.7641.0047.74 B

ATOM 7313 ND1HISB33-1 -16.653-26:082-96.0741.0048.14 B

ATOM 7314 CEl HIS B 331 -16.514-25.435-94.9321.0048.43 B

ATOM 7315 NE2 HIS B 331 -15.225-25.230-94.721 1.0048.63 B

ATOM 731-6 C HISB 331 -15.649-29.390-97.531 1.0045.82 B ATOM 7317 O- fflS B 331 -167351-29.753-98.471 1.0045.56 B

ATOM 73Mf-N ALA-B332 -15.799-29.842-96.2921.0044.68 B

ATOM 7319 CA ALAB 332 -16.817-30,829 -95.9571.0043.26 B

ATOM 7320 CB ALA B 332 -16.702-31.201-94.519 1.0043.65 B

ATOM 7321 C ALA B 332 -18.219 -3G.310 -96.242 1.0042.85 B ATOM 7322 O ALA B 352 -18.554-29.198 -95.8481.-0Θ 41.-84 B

ATOM 7323 N ALA B- 333 -19.037-31.117-96.9191.004245 B

ATOM 7324 CA ALA B 333 -20.400-30.709-97.2491.0041.69 B

ATOM 7325 CB ALA B 333 -20.409-30.019-98.6231.0042.62 B

ATOM 7326 C ALA B 333 -21.411-31.873-97.2241.0041.29 B ATOM 7327 O ALAB 333 -21.048 -33.034-97.4371.00-40.61 B

ATOM 7328 N- ALA-B--334 -22.673-31.544-96.948 1.0041.13 B

ATOM^" 7329 CA ALA B 334 -23.768 -32.508 -96.89-5 LOO 42.47 -B

ATΘM- 733.0. CB ALA B 334 -24.4-14-32.505-95.553.1.00-43.02 B

ATOM^" 7331 C ALA B 334 -24.779 -32J23 -97.9511.0G-44.Θ8^"- B ATOM- 7332 O ALAB-334 -25.285-30:997-97.9861.0044.24 B

ABDM 7333 N TRP B 335- -25.100^"-33.117 -98:7701-0046;47 Br

ATΘM 7334- CA TRP B 335- -25.973 -32τ977 -99.918 1.004-7.69 -B

ATOM 7335 CB^" TRP B 335 -25.167-33,489-101.1021.0.049.12 B

ATOM 7336 CG TRPB 335 -24.188 -32.467-101.309 LOO 50.20 B ATOM 7337 CD2 TRP B 335 -24.497-31.091-101.339 LOO 50.43 B

ATOM 7338 CE2 TRP B 335 -23.279-30.386-101.378 1.0051.19 B

ATOM 7339 CE3 TRP B 335 -25.705-30.375-101.321 1.0050.03 B

ATOM 7340 CDl TRP B 335 -22.822-32.573-101.3451.0049.91 B

ATOM 7341 NEl TRP B 335 -22.263-31.315-101.3841.0050.36 B _y

ATOM 7342 CZ2TRPB335 -23.237-28.988-101.4021.0051.99 B

ATOM 7343 CZ3TRPB335 -25.669-29.009-101.3391.0050.89 B

ATOM 7344 CH2TRPB335 -24.444-28.319-101.3771.0051.44 B

ATOM 7345 C TRP B 335 -27.384-33.498-100.003 1.0047.67 B ATOM 7346 O TRP B 335 -27:612--34.695 -99.9061.0046.77 B

ATOM 7347 N ASP B 336 -28.335 -32.601-100.230^" LOG 48.26 B

ATOM 7348 CA ASP B 336 -29.714-33.036-100.3641.0049.29 B

ATOM 7349 CB ASP B 336 -30.599-32.340-99.3371.0051.04 B

ATOM 7350 CG ASP B 336 -32.058 -32.652 -99.535 H)O 53.78 B ATOM 7351 ODI ASP B 336 -32,369-33.776-99.991 1.0056.55 B

ATOM 7352 OD2 ASP B 336 -32.893-31.776-99:2241.0054.94 B

ATOM 7353 C ASP B 336 -30.211-32.767-101.7861.0049.48 B

ATOM 73540 ASP B 336 -30.652-31.663-102.1071.0048.45 B

ATOM 7355 N PHE B 337 -30.-125. -33.796- 102.6291.0049.75 B ATOM 7356 CA PHE B 337 -3Θ-.545 -33.707- 1O4.-01-91.0049.63- B

ATOM 7357 CB PHEB 337 -30.109-34.947-104.-781 1.0048.95 B

ATOM 7358 CG PHEB 337 -28.63S -35.024-105.013 1.0049.88 B

ATOM 7359 CDl PHE B 337 -27.772-35.367-103.9841.0050.25 B

ATOM 7360 CD2PHEB337 -28.118-34.785-106.2791.0050.65 B ATOM 7361 CEl PHE B 337 -26.393-35.480-104.221 1.0051.12 B

ATOM 7362 CE2 PHE B-337- -26.7451 -34,894^'- 106:529 1.0050.59 B

ATOM 7363 CZ PHEB 337 -25L882--35.243-lO5.50O-r.0051.il B

ATOM 7364 C PHE B 337 -32_^037 -33.510-104.2171,00-49.75 B

-ATOM^~7365 O PHEB333 -32332-33.638-105.326-1.0050.07 JBL ATOM 73661 N TYItB 338 -32.756--33.213-1Θ3.144-U0O 50.23. B^~

ATOM 7367 CA TYK B-338 -34,194-32.984-103.241 HOO 51.49^" B-

ATOM 7368-CB TYRB 338 -34^444.-31.622-103 J814 -1.0051.95- ^~B-

ATOM 7369 CG TYRB 338 -34.300 -30.5S9-102.7991-.0S 53.95 B

ATOM 7370 CDl TYRB 338 -33.033-30.146-102.3-78 1.0053.66 B ATOM 7371 CEl TYRB 338^" -32.902-29.146-101.436 1.0053.99 B

ATOM 7372 CD2 TYRB 338 -35.433-29.980-102.2521.0054.42 B

ATOM 7373 CE2 TYRB 338 -35.326-28.989-101.3161.0054.85 B

ATOM 7374 CZ TYRB 338 -34.062-28.565-100.9061.0054.68 B

ATOM 7375 OH TYR B 338 -34.004-27.543-99.980 1.0054.34 B ATOM 7376 C TYRB 338 -35.027 -33.956-104.065 1.00 52.21 B

ATOM 7377 0 TYR B 338 -35.967 -33.532-104.748 1.00 52.01 B

ATOM 7378 N ASN B 339 -34.693 -35.242-104.004 1.00 52.03 B

ATOM 7379 CA ASN B 339 -35.412 -36.274-104.753 1.00 50.68 B ATOM 7380 CB ASN B 339 -34.523 -36.802-105.890 1.00-50:32. B

ATOM 7381 CG ASN B 339 -33.542 -37.870-105.422 1,00 5033 ^~B

ATOM 7382 ODl ASN B 339 -33.062 -37.831-104.297 1.00 52.55 B

ATOM 7383 ND2 ASN B 339 -33.235 -38.820-106.292 1.0049.18 B

ATOM 7384 C ASNB 339 -35.794 -37.446-103.841 1.00 51.03 B ATOM 7385 O ASN B 339 -36.140 -38.526-104.327 1.0052.04 B

ATOM 7386 N ARG B 340 -35.709 -37.228-102:527 1:00 50.26 B

ATOM 7387 CA ARGB 340 -36.016 -38^41-101.509- 1.0048.27 B

ATOM 7388 CB ARG B 340 -37.504 -38.507-101.492 1.00 48.01 B

ATOM 7389 CG ARGB 340 -38.256 -37.375-102.114 1.00 5Q.62 B ATOM 7390 CD ARG B 340 -39.546 -37.884-102.557 1.00 52.31 B

ATOM 7391 NE ARG B 340 -39,332 -39.212-103.123 1.00 54.77 B

ATOM 7392 CZ ARG B 340 -39.916 -39.563-104.250 1.00 55.51 B

ATOM 7393 NHl ARG B 340 -39.773 -40.763-104.822 1.00 56.00 B

ATOM 7394 NH2 ARG B 340 -40.649 -38.629-104.792 1.00 5538 ff ATOM 7395 C ARGB 340 -35.277 -39.548-101.689 1.0046.88 B

ATOM 7396 O ARG B 340 -35.638 -40.558-101.104 LOQ .47.95 B

ATOM 7397^"N- ALA B 341 -34.249 -35.553-102.517 1.0044165^" B

ATOM 7398- CA ALA B 34-1 -33.532_-4θ.~79S~102J702 l:θθ-44.03 B

ATOM- 7399 CB-AXA B 344- -3W46-41.522- 103.944- 1.00-44:42 B ATOM- 740Q -C ALA B 341 -32.040 -40.613-102.782 1.00^3.72 B-

ATOM 7401 O: ALA-B 34-1 -3-1.295 -41:592-102:727 l,αθ-43τO6 B

ATOM 74O2 N ASP-B 342 -31.593 -39:366-102.888 1.00"43v64 B_

ATOM 7403 CA ASP B 342 -30.159 -39.105-102.971 1.00 44.13 B

ATOM 7404 CB ASP B 342 -29.760 -38^58-104.385 1.0046.70 B ATOM 7405 CG ASP B 342 -28.940 -39.711-105.116 1.00 48.97 B

ATOM 7406 ODl ASP B 342 -27.851 -40.087-104.616 1.00 50.10 B

ATOM 7407 OD2 ASP B 342 -29.391 -40.167-106.188 1.0049.73 B

ATOM 7408 C ASP B 342 -29.641 -38.097-101.960 1.0042.77 B

ATOM 7409 O ASP B 342 -30.063 -36.937-101.933 1.00 41.99 B ATOM 7410 N PHE B 343 -28.720 -38.570-101.124 1.00 41.35 B

ATOM 7411 CA PHE B 343 -28.094 -37.755-100.095 1.00 39.23 B

ATOM 7412 CB PHE B 343 -28.734 -37.962 -98.723 1.00 36.28 B

ATOM 7413 CG PHE B 343 -30.213 -38.116 -98.-749 LOO 32.81 B ATOM 7414 CDl PHE B 343 -30.781 -39.355 -99.0-17 1.00 32.07 B^"

ATOM 7415 CD2 PHE B 343 -31.037 -37.033 -98.493 1.00 31.63 B

ATOM 7416 CEl PHE B 343 -32.152 -39.520 -99.024 1.00 31.53 B

ATOM 7417 CE2 PHE B 343 -32.413 -37.179 -98.496 1.00 32.35 B

ATOM 7418 CZ PHE B 343 -32.975 -J8.430 -987764 1.00 31.91 B ATOM 7419 C PHE B 343 -26.656 -38.216 -99.997 1.00 39.73 B

ATOM 7420 O PHE B 343 -26JL89 -39.410 -99rS18 1.00 39.03 B

ATOM 7421 N ALA B-344 -25.730 -37.272-100.095 1.00 40.67 B

ATOM 7422 CA ALA B 344 -24.322 -37.617-100.000 1.00 41.90 B

ATOM 7423 CB- ALA B 344 -23.716 -37.737-101.399 1.0044.06 B ATOM 7424^" C ALA B 344 -23.551 -36.392 -99.186 1.00 41.99 B

ATOM 7425 O ALAB 344 -24.099 -35.588 -98.728 1.0041.47 B

ATOM 7426 N ALA B 345 -22.266 -36.833 -99.011 1.00 41.69 B

ATOM 7427 CA ALA B 345 -21.413 -35.969 -98.267 1.0042.29 B

ATOM 7428 CB ALA B 345 -21.21« -36.477 -96.833 1.00 43.62 B ATOM 7429 C ALA B 345 -20.077 -35.885 -98.977 1.00 42.58 B

ATOM 7430 O ALA B 345 -19.434 -36.899 -99.252 1.00 4L94 B

AT.ΘM 74-31 N LYS B346- -19;686 -34.650 -99.264 1.00 43.18 B.

ATOM 7432 GA LYS B 346 -Ϊ&440 -34.344 -99,937 1.00-43,96 B

ATOM 7433^' CB LYS B346- -18.663 -33.161J00.867 1.00 44774 B ATOM 7434=CG L-YS B:346 -Y7.629 -32:986401.943 1.00-45.55 B

ATOM 7435 CD LYS BT346. -17.769 -31-669-K>2:538 £00-46.37 B

ATOM 7436 CE iY-S-B346 -1-7:094 -30.331-101-.66O 1.00 46.22 B

ATOM 7437 NZ LYS B 346 -18,0O6 -29.732-100.850 1.00 49.77 B

ATOM 7438-C LYS B 346 -1-7.498 -33.934 -98.832 1.0044.09 B ATOM 7439 O LYS B 346 -17.782 -32.96S -98.134 1.0043.93 B

ATOM 7440 N GLN B 347 -16.397 -34.655 -98.652 1.00 43.71 B

ATOM 7441 CA GLN B 347 -15.454 -34.289 -97.601 1.0044.56 B

ATOM 7442 CB GLN B 347 -16.066 -34.552 -96.217 1.0046.56 B

ATOM 7443 CG GLN B 347 -15.196 -34.101 -95.031 1.0047.41 B ,_ΛΛ

D(JU

ATOM 7444 CD GLN B 347 -15.511-34.864-93.7521.0047.10 B ATOM 7445 OEl GLNB 347 -16.670-35.183-93.480 1.0046.83 B ATOM 7446 NE2 GLNB 347 -14.479-35.151-92.9571.0045.69 B

ATOM 7447 C GLN B 347 -14.148-35.050-97.722 1.0043.98 B ATOM 74480 GLN B 347 -14.138-36.266-97.633 1.0042.17 B

ATOM 7449 N CYS B 348 -13.052-34.327-97.9341.0045.41 B

ATOM 7450 CA CYS B 348 -11.732-34.941-98.060 1.0046.98 B

ATOM 7451 C CYS B 348 -11.272-35.437-96.6891.0048.03 B

ATOM 7452 O CYSΕ 348 -10.263-34.976-96.1581.0048.81 B ATOM 7453 CB CYS B 348 -10.727-33.924-98.6161.0046.56 B ATOM 7454 SG CYS B 348 -11.214-33.230-100.2261.0047.87 B

ATOM 7455 N THRB 349 -12.021-36.387-96.133 1.0048.58 B

ATOM 7456 CA THRB 349 -11.757-36.957-94.8121.0049.34 B

ATOM- 745.7 CB THRB 349 -12.769-38.079-94.4961.0048.96 B ATOM 7458 OGl THR B 349 -14.D89 -37.526 -94.4171.0049.37 B ATOM 7459 CG2 THR B 349 -12.428-38.741-93.1771.0049.52 B

ATOM 7460 C THR B 349 -10.360 -37.5L1 -94.523 1.0049.96 B

ATOM 7461 O THRB 349 -9.932-38.491-95.126 1.0049.60 B

ATOM 7462 N ALAB 350 -9.665 -36.881 -93.579 1.0051.30 B ATOM 7463 CA ALA B 350 -8.336-37.324-93.163 1.0052.64 B

-ATOM^" 7464 CB ALA B 350 -7.403 -36111Ε -92.996 LOO 52.79 B

ATOM 74J65 C ALA.B 350 -8.566 -38.030 -91.8L61.0053.80 B

ATOM 7466 O ALAB-350 -9.686 -38τO-18 -91.301 1.0054dQ3 B

ATOM- 7467 N VAL B 351 -7.539 -3S7652 -94.2^'43^' h0054.42 B ATOM 7468 CA VAL B 351 -7.723-39.331 -89.961 1.0054τ67 -B^~

ATOM- T469.CB VAL B351 -67982-40.659-89.943 -1.0054.18 B

ATOM 7470- CGl-VAL B 351 -7.373-41.445-88.711 1.0054:52- B

ATOM 7471 CG2VALB-351 -7.309-41.436-91.198 1.0053.96 B

ATOM 7472.C VALB 351 -7.269-38.493-88.7541.0055.83- B ATOM 7473 O VAL B 351 -6.098-38.532-88.3661.0055.53 B

ATOM 7474 N THRB 352 -8.215-37.742-88.1771.0056.43 B

ATOM 7475 CA THRB 352 -7.986-36.877-87.0171.0056.63 B

ATOM 7476 CB THRB 352 -7.747-35.407-87.433 1.0057.74 B

ATOM 7477 OGl THRB 352 -6.773-35.351-88.478 1.0059.81 B _ΛM oOl

ATOM 7478 CG2 THRB 352 -7.246-34.587-86.2421.0059.47 B

ATOM 7479 C THRB 352 -9.253-36.891-86.170 1.0056.35 B

ATOM 7480 O THRB 352 -10.336-37.214-86.666 LOO 55.92 B

ATOM 7481 -N ALAB 353 -9.134-36.532-84.8981.0055.47 B ATOM 7482 CA ALAB 353 -10313-36.497-84.051 1.0054.51 B

ATOM 7483 CB ALAB 353 -9.923-36.258-82.651 1.0055.76 B

ATOM 7484 C ALA B 353 -11.232-35.385-84.523 1.0053.72 B

ATOM 7485 O ALA B 353 -12.445-35.565-84.611 1.0053.61 B

ATOM 7486 N ALA B 354 -10.649 -34.229 -84.^~8161.0052.83 B ATOM 7487 CA ALA B 354 -11.434-33.094-85.2921.0051.70 B

ATOM 7488 CB- ALA B 354 -10.507-31.948-85.6921.0051.84 B

ATOM 7489 C ALA B 354- -12.240-33.557-86.4861.Θ050.82 -B

ATOM 7490 O ALA B 354 -13.418-33.235-86.633 1.0050.30 B

ATOM 7491 N ALAB.355 -11.592-34.343-87.3371.0049.96 B ATOM 7492 CA ALA B 355 -12.23Q -34.364 -88.5321.0048.94 B

ATOM 7493 CB ALA B 355 -11.237-35.687-89.3421.0049.03 B

ATOM 7494 C ALA B 355 -13.457-35.705-88.1771.0048.26 B

ATOM 7495 O ALA B 355 -14.574 -35.441 -88.6501.0047.06 B

ATOM 7496 N ALAB 356 -13.247-36.704-87.325 1.0046.91 B ATOM 7497 CA ALA B 356 -14.328 -37.579 -86.903 l.QO 46.49 B

ATQM 7498 CB ALA B 356 -13.840-38.520-85.811 1.0046.75 B

ATOM ^'7499 C ALA B 3-56 -15.527-36.775-86.410 1.00546.74 B

ATOM- 7500 © ALAB 356 -16.681-37.139-86.66-21.0047.03 B

ATOM 75σi N SERB 357 -15.2621_^35.675-85.711 1.0046.38 B^" ATOM 7502 CA SER B 357 -1-6.355 -34,859 -85.203 1.00-46J.4 -B

ATOM^" 7503- CB SERB 357 -15-856 -33,850 -84.-1-661.0046.95 B

ATOM 7504 OG SERB 357 -15:047 -32.862 -84:7661.0049.31 B

ATOM 7505 C- SER B 357 -16.999-34.135-86.366 LOO 45.1-5 B

ATOM 7506- O SERB 357 -18.177-33.-785-86.321 1.0045.41 -B ATOM 7507 N THRB 358 -16.223-33.905-87.4181.0044.31 B

ATOM 7508 CA THRB 358 -16.763-33.234-88.5891.0042.73 B

ATOM 7509 CB THR B 358 -15.647-32.721-89.5281.0043.93 B

ATOM 7510 OGl THRB 358 -15.043-31.552-88.9561.0045.01 B

ATOM 7511 CG2THRB358 -16.213-32.360-90.903 1.0044.23 B _Q2

ATOM 7512 C THR B 358 -17.625-34.247-89.306 1.0040.78 B

ATOM 7513 O THRB 358 -18.611-33.889-89.949 1.0039.93 B

ATOM 7514 N VAL B 359 -17.257-35.521-89.172 1.0039.08 B

ATOM 75T5 CA VAL B 359 -18.024-36,592-89.800 LOO 37.54 B ATOM 7516 CB VAL B 359 -17.302 -37.949 -89.7121.0035J9 B

^TOM 7517 CGl VAL B 359 -18.197-39.039 -90.2371.0035.1G B

ATOM 7518 CG2VALB359 -16.035-37.916-90.5191.0035.17 B

ATOM 7519 C VAL B 359 -19.367-36.676-89.093 1.0037.70 B

ATOM 7520 O- VAL B 359 -20.385-37.008-89.700 1.0037.47 B ATOM 7521 N HIS B 360 -19.368. -36.3J67 -87.8021.0037.81 B

ATOM- 7522^' CA HIS-B 360 -20.613 -36.384 -87.05S 1.0038.35 B

ATOM T523 CB HIS B 360 -20.352 -36.382 -85.545 1,0037.24 B

ATOM 7524 CG HIS B 360 -20.069-37.737-84.985 1.0035.58 B

ATOM 7525 CD2HISB360 -20.863 -38.604 -84Jl 1 1.0034.78^ B ATOM 7526 -NDl HIS B 360 -18.858-38.376-85.1531.0035.47 B

ATOM 7527 CEl HIS B 360 -18.919 -39.578-84.6071.0034.90 B

ATOM 7528 NE2 HIS B 360 -20.125-39.742-84.091 1.0034.15 B

ATOM 7529 C HIS B 360 -21.448-35.169-87.4521.0038.68 B

ATOM 7530 O HIS B 360 -22.652-35.291-87.6921.0037.44 B ATOM 7531 N HIS B 361 -20.796-34.007-87.5371.0039.78 B

ATOM- 7532 CA HI-S-B 361 -21.484-32.766-87.8941.004L00 B

ATOM 7533 CB HIS-B 361 -20.515-31.573--87.9261.0038.62 B

ATOM 7534-CG- HIS B 361 -2L094 -30.352 -88.5791.0036.25 B ATOM- 7535 CD2 HIS-B^iόl -20.923 -29:84-7 =89^825 LOO 34.80=^ B^" ATOM 75-36- NDl HIS B 361 -22.041-29.555-87.973 1.0035.18 B

ATOM 75S-7-CE1 HiS-B-361 -22:433 -28.617 -88.8118- 1.0033.88 B

ATOM 7538 NE2 HIS-B 36Ϊ -21.769 -28.773 -89.9491.0033.28 B

ATOM 7539 C_ HIS B 361 -22.137-32.892-89.2561.0042.72 B

ATOM 7540 O HIS B 361 -23.300-32.492-89.4441.0041.85 B ATOM 7541 N GLU B 362 -21.384-33.452-90.2041.0044.34 B

ATOM 7542 CA GLU B 362 -21.892-33.615-91.5621.0045.27 B

ATOM 7543 CB GLU B 362 -20.771-34.054-92.515 1.0045.43 B

ATOM 7544 CG GLU B 362 -19.704-32.965-92.7861.0046.67 B

ATOM 7545 CD GLU B 362 -20.282-31.652-93.331 1.0047.41 B ATOM 7546 OEl GLU B 362 -21.506-31.571-93.583 1.0047.21 B

ATOM 7547 OE2 GLU B 362 -19.499 -30.692 -93.506 1.0048.63 B

ATOM 7548 C GLU B 362 -23.049-34.590-91.614 1.0044.95 B

ATOM 7549 O GLUB 362 -24.094-34.297-92.1971.0045.35 B ATOM 7550 N METB-363 -22.882^~-35.735 -90.972 1.0044.64 B

ATOM 7551 CA MET B^"363 -23.93^"5 -36.738 -90.979- 1.0045.28 B

ATOM 7552 CB MET B 363 -23.451-38.009-90.297 1.0046.07 B

ATOM 7553 CG MET B 363 -24.294-39.221-90.594 1.0047.67 B

ATOM 7554 SD^" MET B 363 -23.356-40.718-90.2321.0052.42 B ATOM 7555 CE METB 363 -22.284-40.822-91.675 1.0052.19 B

ATOM 7555-C METB"363 -25.192 -36232 -90.2991.0044.69 B

ATΘM 7557 O METB 363 -26.304-36.639-90.6401.0045.39 B

ATOM 7558 N GLYB 364 -25.013-35.341-89.3341.0043.90 B

ATOM 7559 CA- GLY B 364 -26.160-34.808-88.6391:0042.98 B ATOM 7560 C GLY B 364 -^"27.046 -34.133 -89_^651 1.0042.29 B

ATOM 7561 O GLYB 364 -28.272-34.161-89.5391.0043.18 B

ATOM 7562 N HIS B 365 -26.427-33.523-90.655 1.0041.70 B

ATOM 7563 CA fflS B 365 -27.170-32.880-91.733 1.0040.18 B

ATOM 7564 CB HIS B 365^~ -26.213-32.186-92.7041.0039.92 B ATOM 7565 CG HIS B 365 -25.728 -30.853 -92.2251.0038.95 B

ATOM 7566. CD2 HIS3365 -24.476-30.38-7-92.003 1.0039.86 B

ATOM 7567 NDΪΗIS-B 365 -^"26.583-29.818-91.915 1.0037.46 B

ATOM 7568 CEl HJSJB 365 -25.879 =28.771 -91.5221.0038.79 B

ATOM 7569 NEZEBS B 365 -24.598 -29.090 -91:566 IJOO 41.04 B ATOM 7570 C HJSΕ 365 -28.047.-33,879-92.481 1. OQ 39.34 B

-ATOM^" 7571 O- MS B 365 -29.248-33:665-92:644 1-0037:69 B

ATOM 7572 N ILE.B366 -27.439-34.972-92:933 LOO 39.09 B

ATOM 7573 CA DbE B 366 -28.180 -36τQ46 -93.582 1.0039.31 B

ATOM 7574 CB ILE B 366 -27.275-37.274-93.798 1.0037.97 B ATOM 7575 CG2ILEB366 -28.067-38.420-94.408 1.0036.99 B

ATOM 7576 CGl ILE B 366 -26.083 -36.908 -94.6841.0038.34 B

ATOM 7577 CDl ILE B 366 -24.957 -37.919 -94.6401.0036.48 B

ATOM 7578 C ELE B 366 -29.409 -36.439 -92.768 1.0040.17 B

ATOM 75790 ILE B 366 -30.543-36.192-93.179 1.0039.40 B _rnA

604

ATOM 7580 N GLN B 367 -29.175-37.050-91.612 1.0040.98 B

ATOM 7581 CA GLN B 367 -30.257-37.593-90.799 1.0041.88 B

ATOM 7582 CB GLN B 367 -29 J 47 -37.949 -89 Λ01 1.0042.59 B

ATOM 7583 CG GLN B 367 -30.807 -38.538 -88.485 1.0042.95 B ATOM 7584 CD GLN B 367 -31.158-39:968-85.845 1.0043.21 B

ATOM 7585 OEl GLN B367 -32.332 -40.337 -88.857 LOO 43.6T B

ATOM 7586 NE2 GLN B 367 -30.143-40.776-89.128 1.0041.63 B

ATOM 7587 C GLNB 367 -31.419-36.610-90.699 1.0041.99 B

ATOM 7588 O GLNB 367 -32.580 -37.OK -90:6191.00 ^"42.71 B ATOM 7589 N TYRB 368 -31.097-35.321-90.7031.0041.08 B

ATOM 7590 CA TYRB 368 -32.104-34.278-90:855 1.00-4-1.60 ^"B

ATOM 7591 CB TYR B-36.8 -3 IA73. -32.895 -90.678 1:0040.16 B

ATOM 7592 CG TYRB 368 -32.368-31.899-89.9761.0038.91 B

ATOM 7593 CDl TYRB 368 -31.831-30.840-89.256 1.003-9.15 B ATOM 7594 CEl TYRB 338 -32.645 -29:927 -88.6141.00^~39.24- B

ATOM 7595 CD2 TYR B 368 -33.750-32.017-90.0341.0039.30 B

ATOM 7596 CE2 TYRB 368 -34.572-31.109-89.395 1.0040.76 B

ATOM 7597 CZ TYRB 368 -34.014-30.066-88.6861.0040.94 B

ATOM 7598 OH TYRB 368 -34.828-29.159-88.0471.0041.20 B ATOM 7599 C TYR B 368 -32.792-34.370-92.2131.0042.96 B

ATOM 7600 O TYRB 368 -34.01-5 -34.26.6 -923.091.0044,36 B

ATOM 76Θ1 N TYR B 169 -31.998 -34.565 -93^~.261 1.00-4Z.8T B^~

ATOM 7602 CA TYR3369 —32.535 -34τ69-7 -94J5261.0042.57 JB-

AIOM 7603 -CB TYRB 369 -31.3£-8--34.83S=95.651 1.004Θ.92 B ATOM 7604 CG- TYRrB.369 -3.0.491 -337615 -95.83-3 1.0038.06- -B AT£iM- 7605 CDl TYRB 369 =29.147-33.774-96.193 1.0035.1-8 B-

ATOM- 7606 CErTYRB-369 -28.310-32:6-83 -9A3671.0035.O0 B

ATOM 7607 CD2 TYRB 369 -30.984 -32.306- -95.6541.003.6.73 B-

ATOM 7608 CE2 TYR B 369 -30rt53 -31.-194 -95.831 1.0036.63 B ATOM 7609 CZ TYRB 369 -28.809-31.390-96.1871.0037.00 B

ATOM 7610 OH TYR B 369 -27.957-30.303-96.346 1.0037.06 B

ATOM 7611 C TYRB 369 -33.449-35.928-94.721 1.0042.54 B

ATOM 76120 TYRB 369 -34.578-35.860-95.2291.0041.12 B

ATOM 7613 N LEUB 370 -32.942-37.051-94.223 1.0043.16 B _ω

ATOM 7614 CA LEU B 370 -33.677-38.302-94.231 1.0044.01 B

ATOM 7615 CB LEUB 370 -32.809-39.396-93.620 1.0042.34 B

ATOM 7616 CG LEUB 370 -31.492-39.662-94.345 1.0044.04 B

ATOM 7617 CDl LEU B 370 -30.622-40.550-93.501 LOO 44.65 B ATOM 7618 CD2 LEU B 370 -31.754 -40.334 -95.676^" 1.0045.35 B

ATOM 7619 C LEUB 370 -35.003-38.207-93.470 LOG 45.45 B

ATOM 7620 O LEUB 370 -35.988-38.823-93.8581.0047.12 B

ATOM 7621 N GLNB 371 -35.032-37.424-92.398 1.0046.08 B

ATOM 7622 CA GLN B371 -36.229-37.299-91.5791.0046.67 B ATOM 7623 CB GLN B 371 -35.869 -36.813 -90.1741.0046.32 B

ATOM- 7624 CG GLN B 371 -35:137-37.842-89.3271.0044.57 B

ATOM 7625 CD GLNB 371 -35.933 -39.119 -89.159 l.GG^:43.24 B

ATOM 7626 OEl GLN B 371 -37.165-39.095-89.1041.0042.76 B

ATOM 7627 NE2 GLN B 371 -35.233-40.242-89.059 1.0041.74 B ATOM 7628 C GLNB-371 -37.350-36.439-92.1321.0048.29 B

ATOM 7629 O GLN B 371 -38.501 -36.662-91.8081.0049.15 B

ATOM 7630 N TYRB 372 -37.064-35.440-92.9461.0050.27 B

ATOM 7631 CA TYR B.372 -38.206-34.670-93.4641.0052.48 B

ATOM 7632 CB TYRB 372 -38.175-33.223-92.973 1.0054.18 B ATOM 7633 CG TYRB 372 -36.918 -32.497-93.3571.0057.W B

ATOM 7634 CDl TYRB 372 -36.790-31.125-93.116 1.0058.43 B

ATOM 7635 CElTYR B^"372 -35.627 -3:0...460 -93.4 IS LOO 60.35 B

-ATΘM 7636 CD2 TYR-B 372 -35r835 -33.195 -93J»25 1.00-57.99 B-

ATOM 7637 CE2 TYRB 372 -34.666-32.557^4.2371.00-59.4O B - ATOM 763S CZ TYRB-372 -34.560 -31.1£8 -93.9-86 1.0061.21 B^'

ATOM 7639 OH TYR B 372 -33:387 -30.547 -94.3241,0062.37- Η

ATOM- 7.640 C TYRTB 372^~ -38τ313 -34τ680 -947998-1.0052.5S B

ATOM 7641 O TYRB 372 -38.765-33.721-95.616 1.0-052.42 B

ATOM 7642 N LYS B 373 -37.895 -35.781 -95.601 1.00-52.54^" B ATOM 7643 CA LYS B 373 -37.981-35.910-97.0421.0052.46 B

ATOM 7644 CB LYS B 373 -37.185-37.127-97.493 1.0050.60 B

ATOM 7645 CG LYS B 373 -37.815-38.402-97.0921.0048.34 B

ATOM 7646 CD LYS B 373 -36.810-39.454-97.2791.0047.39 B

ATOM 7647 CE LYS B 373 -37.471-40.777-97.328 1.0046.82 B ,_n,

ATOM 7648 NZ LYS B 373 -36.457-41.836-97.493 1.0046.70 B

ATOM 7649 C LYS B 373 -39.486-36.094-97.3041.0052.86 B

ATOM 7650 O LYS B 373 -39.979-35.894-98.405 1.0052.79 B

ATOM 7651 N ALA B 374 -40.191-36.460-96.2371.0053.01 B ATOM 7652 CA ALA B 374 -41.629-36.695-96.259 1.0053.19 B

ATOM 7653 CB ALA B 374 -42.072-37.185-94.902 1.0053.57 B

ATOM 7654 C ALA B 374 -42.418-35.437-96.600 1.0053.82 B

ATOM 7655 O ALAB 374 -43.591-35.511-97.013 1.0053.40 B

ATOM^" 7656 N ALAB 375 -4-1.775-34.283-96.459 1.0054.76 B ATOM 7657 CA ALA B 375 -42.476-33.022-96.705 1.0056.30 B

ATOM 7658 CB ALAB375 -42.044-32.012-95.633 1.0056:09 B

ATOM 7659 C ALA B 375 -42.343-32.355-98.063 1.0057.37 B

ATOM 7660 O ALAB 375 -41.690-32.856-98.959 1.0057.29 B

ATOM 7661 N PRO B 376 -43.089-31.247-98.2491.0058.33 B ATOM 7662 CD PRO B 376 -44.396-31.016-97.6041.0058.47 B

ATOM 7663 CA PRO B 376 -43.011 -30.506-99.508 LOJO 59.58 B

ATOM 7664 CB PROΕ 376 -44.089-29.424-99.349 1.0058.21 B

ATOM 7665 CG PRO B 376 -45.131 -30.093 -9&5991.0057.76 B

ATOM 7666 C PRO B 376 -41.623-29.916-99.453 1.0061.08 B ATOM 7667 O PRO B 376 -41.362-29.167-98.539 1.0063.63 B

ATOM 7668 N ALAB 377 -40.734-30.281-100.378 1.0061.03 B ATOM 1669 £A ALA B 377 -39362 -29.752-100.394- 1.0060.20 B^~

ATOM 7670 CB ALAB 377 -38J785 -29.808.-101.7961.0060:98 B

ATOM 7671 C ALAB'377 -39.271 -28.310--99.880 UHL59.38 B- ATOM 7672 O- ALA B3-77 -38.395 -27.965 -99,0:81 1.0059.07 B

ATOM 7673 N SERB 378 -40.167 -27.462-100.3601:0057:62 B

ATOM 7674 CA- SERB 378 -40: L68 -26.07-S -997935 1.0057.92 B

ATOM 7675 CB SERB 378 -41.411 -25.431-100.478 1.0057.61 B

ATOM 7676 OG SERB 378 -41.797 -26.212-101.580 LOO 57.96 B ATOM 7677 C SERB 378 -40.104-25.939-98.4121.0058.48 B

ATOM 7678 O SERB 378 -39.912-24.840-97.891 1.0059.25 B

ATOM 7679 N LEUB 379 -40.258-27.062-977121.0058.65 B

ATOM 7680 CA LEUB 379 -40.201-27.111-96.2541.0057.48 B

ATOM 7681 CB LEUB 379 -41.542-27.595-95.6801.0056.73 B „_ oO/

ATOM 7682 CG LEUB 379 -42.766-26.716-95.928 1.0056.38 B

ATOM 7683 CDl LEUB 379 -43.978-27.313-95.2441.0057.07 B

ATOM 7684 CD2 LEU B 379 -42.496-25.329-95.392 1.0056.16 B

ATOM 7685 C LEUB 379 -39.116-28.055-95.7391.0057.18 B ATOM 7686 O LEUB 379 -38.880-28.0.82-94.5421.0058.07 B

ATOM 7687 N SERB 380 -38.482-28.826-96.6341.0037.17 B

ATOM 7688 CA SERB 380 -37.408-29.774-96.280 1.0057.19 B

ATOM 7689 CB SERB 380 -37.079-30.668-97.4571.0056.90 B

ATOM 7690 OG SERB 380 -36.157-31.661-97.0561.0056.71 B ATOM 7691 C SER B 380 -36.256-287872-95.959 1.0057.54 B

ATOM 7692 O . SERB 380 -35.139 -28.944 -96.505 1.0057.58 B

ATOM 7693 N ARGB 381 -36.571 -2S.040 -94.9921.0057.8-1 B

ATOM 7694 CA ARGB 381 -35.709-26.982-94.570 1.0057.43 B

ATOM 7695 CB ARG B 381 -36.372-25.685-95.035 1.0057.96 B ATOM 7696 CG ARGB 381 -35.511-24,729-95.825 1.0060.11 B

ATOM 7697 CD ARGB 381 -36.227-24.385-97.151 1.0061.73 B

ATOM 7698 NE ARGB 3Sl -36.126 -22.971 -97.510 J.0063.1-1 B

ATOM 7699 CZ ARG B 381 -36.029-22.515 -98.758 LOG 64.02 B

ATOM 7700 NHl ARGB 381 -36.016-23.372-99.772 1.0064.88 B ATOM 7701 NH2 ARG B 381 -35.942-21.205-98.9911.0062.61 B

ATOM 7702 C ARGB 381 -35.577-26.914-93.055 LOO 56.81 B

ATOM 77Θ3 O ARGB 381 -36.564-26.-758-92.3401:0057.24 B

ATOM 7704 N GLYB 382 -34.331 -26.889 -92,6Og-LQO 55.49 B

ATOM 7705 €A-OLY-B:382 -34.058 -26τ808-91.192 1.0052724 B ATOM 7706 C GLYJ3382 -35:083 -25.826.-90.660= 1.00-49.92 B

ATOM 7707 O GEY B 3.82- -35.634-24.962-93.373 1.00.-49.08 B

ATOM 7708-N ALAB 383 -35.318-25.961-89.365 1.0047:91 B

ATOM- 7709 CA ALA B 383 -36.307-25.156-88.637 1.0045.59 B

ATOM 7710 CB ALA B 383 -36.425 -25.679 -87.2-801.0046.85 B ATOM 7711 C ALA B 383 -35.890-23.696-88.6321.0043.95 B

ATOM 77120 ALAB 383 -36.695-22.779-88.605 1.0043.14 B

ATOM 7713 N ASNB 384 -34.586-23.564-88.5241.0042.36 B

ATOM 7714 CA ASN B 384 -33.865-22.336-88.705 1.0040.61 B

ATOM 7715 CB ASNB 384 -33.782-21.309-87.5441.0041.99 B _rno oυo

ATOM 7716 CG ASNB 384 -33.111-21.812-86.3171.0043.19 B

ATOM 7717 ODl ASN B 384 -32.140-22.572-86.3471.0043.14 B

ATOM 7718 ND2 ASN B 384 -33.625-21.367-85.1961.0042.37 B

ATOM 7719 C ASN B.384 -32.550-22.935-89.0201.0038.82 B ATOM 7720 O ASNB 384 -32.214 -24.066-88.613 1.0037.29 B

ATOM 7721 N PRO B 385 -31.811-22.204-89.8161.0037.20 B

ATOM 7722 CD PRO B 385 -32.204 -20.897 -90.3761.0036.46 B

ATOM 7723 CA PRO B 385 -30.490-22.616-90.2501.0036.74 B

ATOM 7724^" CB PRO B 385 -29.918 -21.331 -90.831 1.003T.97 B ATOM 7725 CG PROB 185 -31.150-20.670-91.4041.0036.87 B

ATOM 7726 C PRO B 385 -29,662-23.182-89.1061.0036.78 B

ATOM 7727 O PROB 3β5 -28,886-24.121-89.2931.0015.52 B

ATOM 7728 N GLYB 386 -29.871-22.620-87.9171.0037.45 B

ATOM 7729 CA GLY B 386 -29-145 -23.058 -.86.7461.0036.99 B ATOM 7730 C GLY B 386 -29.327 -^"24.521 -86.403 1,0038,23 B

ATOM 7731 O GLYB386 -28.347-25.275-86.291 1,0038.11 B

ATOM 7732 N PHEB 387 -30.585 -24.921 -86.2J41.0038.54 B

ATOM 7733 CA PHE B 387 -30.917-26.297-85.9001.0039.37 B

ATOM 7734 CB PHE B 387 -32.384-26.584-86.185 1.0041.55 B ATOM 7735 CG PHE B 3.87 -33.319 -26J70 -85.14-1 1.0043.41 B

ATOM 7736 CDl PHE B 3*7 -33.386 -24.714 -84.8501.00^~44.06 B

ATOM 7737 CD2 PHE B 3£7 -34.155 -26:946 -"84:461 1.0044.35- B

ATOM 7738 CELPHE B-387 -34.275 -24.233 -.83.895 1.0045^80 B

ATOM 7739-CE2 PHEB 38-7- -35:044 -26.4S3 -.83^508 1.0046.42 B ATOM 7740 CZ PHE B 387 -35.106-25.119-83^231.0046.95 B

ATOM 774-1- C PHEB 387 -30.09-0 -27.286 -86.685 L00-4Θ.73 B

ATOM^" 7742 O PHE B 387 -29.663-28.305-86.1371.00^41.64 B

ATOM 7743 N HIS B 388 -29,875-26.986-87.9671.0040.90 B

ATOM 7744 CA HIS B-388 -29.113 -27.861 -88.852_ 1.0040.52 B ATOM 7745 CB HIS B 3S8 -29.114-27.296-90.2671.0042.26 B

ATOM 7746 CG HIS B 388 -29.787-28.184-91.2661.0042.70 B

ATOM 7747 CD2 HIS B 38S -31.003-28.095-91.8581.0041.45 B

ATOM 7748 NDl HIS B 388 -29.217-29.358-91.721 1.0042.44 B

ATOM 7749 CEl HIS B 388 -30.059 -29.956 -92.5461.0043.07 B _6rø

ATOM 7750 NE2 HIS B 388 -31.148-29.211-92.645 1.0043.62 B

ATOM 7751 C HIS B 388 -27.688-28.095-88.4061.0040.96 B

ATOM 7752 O HIS B 388 -27.283 -29.234 -88.178 1.0040.66 B

ATOM 7753 N GLlTB 389 -26.919-27.020-88.285 1.0041.98 3 ATOM 7754 CA GLϋ B 389 -25.526-27.147-87.873 1.0043.15 B

ATOM 7755 CB GLUB 389 -24.845-25.772-87.8491.0044.43 B

ATOM 7756 CG GLU B 389 -25.030-24.922-89.122 1.0044.85 B

ATOM 7757 CD GLUB 389 -24.982-25.738-90.416 1.0043.10 B

ATOM 7758 OEl GLU B 389 -24.275 -26.759 -90.4651.00^"41.77 B ATOM 7759 OE2GLUBΪ89 -25.643-25.348-91.3941.0041.54 B

ATOM 7760 C GLUB^~389 -25.419-27.783-86.4921.0043.04 B

ATOM 7761 O GEU B 389 -24.380-28.347-86.131 1.0043.18 B

ATOM 7762 N ALA B 390 -26.511-27.703-85.735 1.0042.53 B

ATOM 7763 CA ALA B 390 -26.552 -28.216 -84.3721.004L89 B ATOM- 7764 CB ALA B 390 -27.716-27.588-83.643 1.0042.83 B

ATOM 7765 C ALAB 390 -26.609-29.727-84.235 1.0041.27 B

ATOM 7766 O ALAB 390 -25.775-30.346-83.5781.0041.01 B

ATOM 7767 N ELE B 391 -27.609 -30.317 -84.8461.0039.83 B

ATOM 7768 CA BLE B 391 -27.757-31.741-84.7741.0038.85 B ATOM 7769 CB ILE B 391 -28.500 -3Z 167 -85.9521.0036.23 B

ATOM 7770 CG23LE B 391 -28.904 -33.628 -85.813 1.0034.08 B

ATOM- 7771 CGl ILEJB 391 -29,690. -31,250 -86rθ62 LOO 34.56- B

ATOM 7772 CDl ILE B-394- -30.858-31.845-85.4221.0034.76 B

ATOM 7773 C ELE B 391 -26.508: -32,597 -84.652 LΘΘ40J&8 B ATOM 7774 O DLETB 391 -26.300-33.285-83.673 1.0041.10 B

ATOM 7775 N GL-Y-B 392 -25.657-32 J59^"-85J6481.004170 B

ATOM.7776 CA GLY B 392 -24.494 -33\408 -85.572 1.0043.71 B

ATOM 7777 C GLY B 392 -23.637-33.129-84.371 1.004483 B

ATOM 7778 O GLY B 392 -23.054-34.045-83.7961.0045,03 B ATOM 7779 N ASPB 393 -23.546-31.861-83.981 1.0046.53 B

ATOM 7780 CA ASP B 393 -22.687-31.521-82.8481.0047.43 B

ATOM 7781 CB ASPB 393 -22.439-29.981-82.7971.0047.56 B

ATOM 7782 CG ASP B 393 -21.268-29.536-83.741 1.0046.94 B

ATOM 7783 ODl ASP B 393 -20.445-30.414-84.114 1.0045.82 B _61Q

ATOM 7784 OD2 ASP B 393 -21.165-28.329-84.093 1.0045.52 B

ATOM 7785 C ASP B 393 -23.136-32.141-81.5001.0046.95 B

ATOM 7786 O ASP B 393 -22.303-32.675-80.753 1.0046.93 B

ATOM 7787 N VAL B 394 -24.444-32.140-81:2401.0046.08 B ATOM 7788 CA VALB-394 -_25.Θ14 -32.726 -80.0271.0045.22 B

ATOM 7789 CB VAL B.394 -26.550-32.754 -80.1101.0044.80 B

ATOM 7790 CGl VAL B 394 -27.157-33.043-78.749 1.0044.91 B

ATOM 7791 CG2VALB394 -27.070-31.429-80.634 1.0044.26 B

ATOM 7792 C VAL B 394 -24.505-34.157 -79.843 1.0044.93 B ATOM 7793 O VAL B 394 -24.034-34.528-78.7661.0045.89 B

ATOM 7794 N LEUB395 -24.594 -34.963- -80,893^" 1.0043.94 B

ATOM 779.5 CA LEUB.395 -24.136 -36.343 -80.805 1.0044.05 B

ATOM 7796 CB LEUB 395 -24.522-37.116-82.0691.0044.18 B

ATOM 7797 CG LEU B 395 -25.977-37.597-82.106 1.0044.50 B ATOM 7798 CDl LEU B 395 -26.930 -36.41-8--81.873 1.0044.22 B

ATOM 7799 CD2LEUB395 -26.259-38.263-83.4301.0044.12 B

ATOM 7800 C LEU B 395 -22.639-36.439-80.581 1.0044.01 B

ATOM 7801 O LEUB 395 -22.159-37.314-79.861 1.0044.83 B

ATOM 7802 N ALAB 396 -21.896-35.5-31-81.193 1.0044.29 B ATOM 7803 CA ALA B 396 -20.443-35.542-81.053 1.0044.52 .B

ATOM 7804 CB ALA-B-396- -19.821-33,542-82.0121.00-45.16 B

ATOM 7805 C ALA B 396- -20:045 -35.2T9 -79-6.18- 1.0043_^93 B

ATOM 7806 Q- ALA B Ϊ96- -18.939 -35.578 -79.L6JL 1.0042.72 B

ATOM 7807 N JLE&B 397 -20.933 -34.528-78.9151.0044.27 B_ ATOM 7808 CA LEUB^~397 -20.680 -34.178-77.525 1.0044.74 B

ATOM 7809 CBTLEU B-J97 -21.800 -33.278 -76τ979 1,00-43.-83 B

ATΘM- 7810 CG LEU B 397 -2U39 -31.804 -77.384 1.0044.20^" B-

ATQM 7811 CDl LEUB 397 -23.018 -31.095 -76.984rl.0045.03 B

ATOM 78L2 CD2 LEU B 397 -20.533 -31.15^-76.7281.0044.20 B ATOM 7813 C LEUB397 -20.588-35.439-76.6771.0044.66 B

ATOM 7814 O LEUB 397 -19.823-35.493-75.718 1.0045.87 B

ATOM 7815 N SERB 398 -21.356-36.459-77.0501.0043.67 B

ATOM 7816 CA SERB 398 -21.381-37.713-76.3071.0041.85 B

ATOM 7817 CB SERB 398 -22.772-38.322-76.4001.0039.18 B _6π

ATOM 7818 OG SERB 398 -23.744-37.291-76.337 1.0036.03 B

ATOM 7819 C SERB 398 -20.323-38.696-76.7961.0043.02 B

ATOM 7820 O SER B 398 -20.066-39.714-76.1521.0044.75 B

ATOM 7821 N VALB399 -19.708-38.393-77.932 1.0042.91 B ATOM 7822 CA VAL B 399 -18.661 -39.249 -78,455 1:0043.29 B

ATOM 7823 CB VAL B 399 -18.612-39.225-80.012 1.0043.95^" B

ATOM 7824 CGl VAL B 399 -17.455-40.090-80.5101.0043.28 B

ATOM 7825 CG2 VAL B 399 -19.920 -39.698 -80.6001.0042.33 B

ATOM ^"7826 C VAL B 399 -177357 -38.674-77.9181.0044.15 ^~R ATOM 7827 O VAL B 399 -16.390 -39.402 -77.7101.0043.53 B

ATOM 7828 N ALA B 400 -17.350 -37.360 -77M71.0045.77^" B ATOM^' 7829 CA ALA B 400 -16.161 -36.672 -77.L81 1.0047.14 B

ATOM 7830 CB ALA B 400 -16.361-35.154-77.2381.0046.92 B

ATOM 7831 C ALA B 400 -15.813-37.096-75.7541.0048.11- B ATOM 7832 O ALA B 400 -14.654-37.008-75.3321.0047.86 B

ATOM 7833 N THRB 401 -16.823-37.567-75.021 1.0049.29 B

ATOM 7834 CA THRB 401 -16.636-38.002-73.6371.0050.13 B

ATOM 7835 CB THR B 401 -17.973-38.354-72.9691.0049.45 B

ATOM 7836 OGl THRB 401 -18.546-39.489-73.621 1.0050.61 B ATOM 7837 CG2 THR B 401 -1-8.938-37.182-73.0471,0047.58 B

ATOM 7838 C THRB 401 -15.704 -39.2-03 -73.499 LOO 5-L23 B^~

ATOM 7339 O THR-B 401 -15.783 -40.168 -74.263 LOO 5Ϊ.06 B

ATOM 7840 N PRO B- 402- -14_J9&-39=446 -72.5121-.Θ05234 B-

ATOM 784LJCD PRO=B 402 -14.542-37:961-74.673 LD0^~52.35 B ATOM 7842 CA PRO B 402 -13:818-40.199 -72:230^ 1.00-^'53.1S B

ATOM 7S43 -GB-PRO-B^'402 -13.070-39.649-71.017 1.0053.50 B-

ATOM 7844 CG PRO B.402 -13:099-38:171.-71.2581.0052.32 B

ATOM 7845 C PRO B 402 -14.456 -4.1.556 -71.964 1.00-53.89 B

ATOM 784.6 O PRO B 402 -13.850-42-597-72.205 1.0053.29 B ATOM 7847 N ALA B 403 -15.688 -41.538 -71.4T4 LOO 55.42 B

ATOM 7848 CA ALA B 403 -16.395-42.777-71.176 1.0057.00 B

ATOM 7849 CB ALA B 403 -17.589-42.486-70.2541.0057.58 B

ATOM 7850 C ALA B 403 -16.859-43.495-72.451 1.0057.43 B

ATOM 7851 O ALA B 403 -16.929-44.723-72.4961.0057.43 B „ ,

ATOM 7852 N HIS B 404 -17.164 -42.725 -73.4901.0058.02 B

ATOM 7853 CA fflS B 404 -17.618-43.296-74.7541.0057.16 B

ATOM 7854 CB fflS B 404 -18.413-42.264-75.541 1.0057.50 B

ATOM 7855 CG fflS B 404 -19.073-42.821-76.7621.0058.12 B ATOM 7856 CD2 HIS B 404 -18.607-43.004-78.0201.0058.01 B

ATOM 7857 NDl HIS B 404 -20.364 -43.305 -76.7571.0057.82 B

ATOM 7858 CEl HIS B 404 -20.664-43.763-77.960 1.0057.48 B

ATOM 7859 NE2 HIS B 404 -19.615-43.594-78.745 1.0057.57 B

ATOM 7860 C HIS B 404 -16.424-43.741-75.5791.0056.78 B ATOM 7861 O HIS B 404 -16.467-44.764-76251 1.0056.35 B

ATOM 7862 N ALAE 405 -15.358-42.952-75.523 1.0057.56 B

ATOM 7863 CA ALA B 405 -14.151-43.276-76.2671.005833 B

ATOM 7864 CB ALA B 405 -13.043-42.232-76.0081.0057.74 B

ATOM 7865 C ALA B 405 -13.688-44.672-75.8701.0058.52 B ATOM 78660 ALA B 405 -13,588: -45.537-76.7241.0058.89 B

ATOM 7867 N HIS B 406 -13.425-44.904-74.5871.0058.47 B

ATOM 7868 CA HIS B 406 -12.991-46.242-74.185 1.0058.12 B

ATOM 7869 CB HIS B 406 -12.591 -46.288 -72.703 LOO 57.75 B

ATOM 7870 CG HIS B 406 -13.065 -47.509 -71.9841.0057.89 B ATOM 7871 CD2HISB406 -12.393-48.499-71.3471.0057.46 B

ATOM 7872 NDl HIS B 406 -14.405 -47.781 -71.8141,0057.56 B

ATOM 7873^: CEl HIS-B 406 -14.54-1-48.881-71.0991.0056.66 B

ATOM 7-874 NE2 HIS B 406 -13.336-49.337-70.801 1.0056.67 B

ATOM -7875 -C HISB 406 -14.098 -47231 -74.4521.0038.20 B AZOM 7876 O HIS-B.406 -13.833-48.406 -74.701 ITOO 58.09 B

ATOM 7877 N- LYS B1407 -15.341 -46,759^"=74.404 UOO 58.11 B

ATOM 7878 CA LYS B 407 -l^"6,452^'-47.653 -74.6661.00-53:01" B^~

ATOM 7879 CB LYS B 407 -17.734 -46.901 -74.8661.0056J66 B

ATOM 7880 CG LYS B 407 -18.891-47.731-74.5041.0055.52 B ATOM 7881 CD LYS B 407 -20.051-46.830-74.3461.0055.21 B

ATOM 7882 CE LYS B 407 -20.643-46.976-72.971 1.0053.80 B

ATOM 7883 NZ LYS B 407 -22.070-47.381-73.0751.0053.45 B

ATOM 7884 C LYS B 407 -16.088-48.333-75.9521.0059.00 B

ATOM 7885 O LYS B 407 -16J17 -49.562 -76.083 1.0060.31 B ATOM 7886 N ILE B 408 -15.744-47.530-76.935 1.0058.40 B

ATOM 7887 CA ILE B 408 -15.329-48.155-78.149 1.0056.98 B

ATOM 7888 CB BLE B 408 -15.646-47.320-79.3501.0055.70 B

ATOM 7889 CG2 ILE B 408 -17.031-46.790-79.2001.0054.34 B ATOM 7890 CGl ILE B 408 -14.623 -46.199-79.4931.0Θ 54.63 B

ATOM 7891 CDl ILE B 408 -15.255-44.887-79.6030.0055.13 B

ATOM 7892 C ELE B 408 -13.861-48.157-77.9341.0057.37 B

ATOM 7893 O BLE B 408 -13.375-47.916-76.855 1.0057.37 B

ATOM 7894 N GLY B 409 -13.125-48.437-79.0041.005.8.19 B ATOM 7895 CA GLY B^" 409 -11.680-48.551-78.928 1.0059.90 B

ATOM 7896 C GLY B 409 -11.040-47.215-78.6041.0.061.28 B

ATOM 7897 Q GLY B- 409 -11.690-46.171-78.6701.0062.22 B

ATOM 7898 N ALAB 410 -9.759-47.248-78.253 1.0062.24 B

ATOM 7899 CA ALA B 410 -8.944-46.041-78.205 1.0062.64 B ATOM 7900 CB ALA B 410 -8:807-45.280-79.515 1.0061.78 B

ATOM 7901 C ALA B 410 -9.558-45.162-77.143 1.0062.77 B

ATOM 7902 O ALA B 410 -9.727 -43.950 -77.3181.00.62.49 B

ATOM 7903 N LEUB 411 -10.009-45.782-76.0421.0063,84 B

ATOM 7904 CA LEUB 411 -9:627-45.320-74.713 1.0064.50 B ATOM 7905 CB LEUB 411 -10.668-44.340-74.1691.0063,34 B

ATOM 7906 CG LEU B 411 -10.146-42.986-73.683 1.0062.33 B

ATOM: 7907 CDl LE^TJ-B=411 -11.006-42.457-72.54-51.0061.95- B

ATOM 7908 CD2LEUB411 -8.69-1- -43.092 -73.256 UOO 60,85 B-

-ATQM 7909 C LEUB 411 -9.470 -46.497- -T3-.755 1.0064.97 B- - ATOM 7910 O LEU B 4-14 - 10^444 -47.173 -73.426 Iτβθ 6476- B

AfFOM 79Ll N- ALAB 412 -8.240 -46J738 -73.3121.0065.10 B:

ATOM. 7912-CA ALA B 412 -7.912-47.979-72.6341.0066.09 B

ATOM 7913 CB ALA B 412 -6.397-48.272-72.749 1.0065.25 B

ATOM 7914 C ALA B 412 -8.259-47.746-71.174 1.0066.63 B ATOM 7915 O ALAB 412 -8.962-48.512-70.5101.0067.10 B

ATOM 7916 N ALAB 413 -7.736-46.605-70.7441.0066.93 B

ATOM 7917 CA ALA B 413 -7.801-46.058-69.396 1.0066.23 B

ATOM 7918 CB ALA B 413 -6.384-45.646-68.990 1.0066.58 B

ATOM 7919 C ALA B 413 -8.748-44.870-69.163 1.0065.78 B _m

ATOM 7920 O ALAB 413 -8.404-43.734-69.4891.0065.77 B

ATOM 7921 N VAL B 414 -9.923-45.130-68.5851.0065.30 B

ATOM 7922 CA VAL B 414 -10.900-44.075-682601.0064.96 B

ATOM 7923 CB VALB 414 -12.345 -44.599 -68.252 1.0064.34 B ATOM 7924 CGl VAL B 414 -13.284-43.560-68.859 1.0063.31 B

ATOM 7925 CG2 VAL B 414 -12.422-45.925-68.992 1.0063.98 B

ATOM 7926 C VAL B 414 -10.546-43.644-66.8361.0065.56 B

ATOM 7927 O VAL B 414 -10.950-44.279-65.861 1.0065.95 B

ATOM 7928 N THRB 415 -9.774 -42.569 -66.7321.0065.71 B ATOM 7929 CA THRB 415 -9.310-42.066-65.4471.0065.07 B

ATOM 793Θ CB THRB 415 -8.499 -40J765 -65.633 1.0065.07 B

ATOM 7931 OGl THRrB 415 -9.079 -39.962 -66.675 1.0065.35 B

ATOM 7932 CG2 THRB 415 -7.059-41.113-65.9841.0064.69 B

ATOM 7933 C THRB 415 -KL352 -41.814 -64.3561.0064.81 B ATOM 7934 O THRB 415 -LQ.334-42.459 -63.3021.0064.73 B

ATOM 7935 N ASP B 41 fr -11.257-40.876-64.6141.00-64.24 B

ATOM 7936 CA ASP B 41:6 -12.142-40.360-63.5771.0064.16 B

ATOM 7937 CB ASPB 416 -12.988-41.489-62.984 1.0065.07 B

ATOM 7938 CG ASP B 416 -14.362-41.020-62.549 1.0066.08 B ATOM 7939 ODl ASPB 416 -14.471-40.429-61.4541.0067.97 B

ATOM 7940 OD2 ASPB 416^" -15.391 -41.199-63.235 LOO 66.60 B

ATOM 7941 C ASP-B 416 -11348- -39.667 -62.4741,0063.53 B

ATOM 7942 O ASP B 416 -11.702-39.746-61.2981.00^" 62,94 B

ATOM 7948- N ASP B 417 -iI0.-273--38.989 -62.863 1.06^63.11 B ATOM 7944 CA ASPΕ 417 -S.689 -37.939-62.037 LM 62. IS- B

ATOM.7945- CB ASPB 417 -8.411 _^37.399 -6Z681 1.00163.97 B

ATOM 7946- CG ASP B 417 -7272 -37.265 -61.6901.0066:06 B

ATOM 7947 ODl ASP B 417 -7.545 -36.991 -.60.5021,0067.83 B

ATOM 7948 OD2ASPB417 -6.073-37.416-62.0071.0068.43 B ATOM 7949 C ASP B 417 -10.675 -36.777 -62.0961.0060.98 B

ATOM 7950 O ASP B 417 -11.679-36.838-62.8061.0062.21 B

ATOM 7951 N THRB 418 -10.381-35.719-61.3481.0058.46 B

ATOM 7952 CA THRB 418 -10.784-34.373-61.7341.0055.97 B

ATOM 7953 CB THRB 418 -11.397-33.721-60.481 1.0056.24 B ATOM 7954 OGl THRB 418 -11.318-34.632-59.3771.0056.68 B

ATOM 7955 CG2 THRB 418 -12.894-33.520-60.663 1.0055.07 B

ATOM 7956 C THRB 418 -9.780-33,424-62.381 1.0054.03 B

ATOM 7957 O THRB 418 -10.150-32.361-62.879 1.0053.12 B ATOM 7958 N GLUB 419 -8.509-33.814-62.371 1.0052.23 B

ATOM 7959 CA GLU B 419 -7.462-32.964-62.851 1.0050.42 B

ATOM 7960 CB GLU B 419 -6.058-33.436-62.431 1.0049.50 B

ATOM 7961 CG GLU B 419 -5.629-33.163-61.0241.0049.02 B

ATOM 7962 CD GLU B419 -4.141-32.849-60.920 1.0048.95 B ATOM 7963 OEl GLU B 419 -3.340-33.379-61.727 1.0047.91 B

ATOM^~7964 OE2GLUB419 -3.779-32.072-60.0081.0048.03 B

ATOM 7965 C GLUB 419 -7.717-33.312-64.3021.0049.98 B

ATOM 7966 O GLUB 419 -7.743-32.456-65.163 1.0050.39 B

ATOM 7967 N SER B 420 -7.960-34.596-64.555 1.0048.66 B ATOM 7968 CA SER B 420 -8.227-35.068-65.9191.0045.87 B

ATOM 7969 CB SERB 420 -8.L58 -36.600 -66,014^" 1.0046.10 B

ATOM 7970 OG SER B 420 -9.234-37.200-65.3171.0047.54 B

ATOM 7971 C SER B 420 -9.586-34.620-66.450 1.0043.96 B

ATOM 79720 SER B 420 -9.853-34.698-67.643 l.OQ 44.80 B ATOM 7973 N ASP B 421 -10.454-34.155-65.571 1.0041.70 B

ATOM 7974 CA ASPB 421 -11.765-33.704-66.0081.0041.21 B

ATOM 7975 CB ASP B 421 -12.749=33.766-64.842 1.0042:75 B

ATOM 79-76 GG ASP B 421 -J.4.213 -33.630 -65.2791.0044.83 B

ATOM 7977 ODl-ASPJB-421 - 15.094-331452 -64.4071.0046:60 B ATOM 7978 QD2 ASP B 421 -14.499-33.713-66.488 1.0045.76. B

ATOM- 7979 C ASP-B 421 -1L568 -32.266 -66.429 1.Θ0-41.12. B

ATOM 7980 O ASP B 421 -12.295-31.712-67.2601.0042J4 B^"

ATOM 7981 N ELE B 422 -10.569-31.658-65.809 1.0040.16 B

ATOM 7982 CA ILE B 422 -10.234 -30.269 -66.0741.0038.83 B ATOM 7983 CB ILE B 422 -9.280 -29.753 -64.943 1.0038.36 B

ATOM 7984 CG2 ILE B 422 -7.949 -29.303 -65.4861.0038.74 B

ATOM 7985 CGl ILE B 422 -9.935 -28.569 -64.248 1.0037.97 B

ATOM 7986 CDl ILE B 422 -11.447-28.680-64.168 1.0036.80 B

ATOM 7987 C ILE B 422 -9.642-30.158-67.479 1.0037.59 B ^

ATOM 79880 ILE B 422 -9.953-29.250-68.253 1.0037.16 B

ATOM 7989 N ASNB 423 -8.801-31.127-67.8001.0036.28 B

ATOM 7990 CA ASN B 423 -8.189-31.211-69.105 1.0035.53 B

ATOM 7991 CB ASNB 423 -7.264-32.425-69.1591.0034.67 B ATOM 7992 CG ASN B 423 -5.955-32.166-68.4851.0035.28 B

ATOM 7993 ODl A-SNB 423 -5.461-31.046-68.5001.0036.94 B

ATOM 7994 ND2 ASN B 423 -5.367-33.197-67.9071.0036.64 B

ATOM 7995 C ASN B 423 -9.292-31.339-70.1631.0035.39 B

ATOM 7996 O AfSNf BT423 -9384- -30.538 -71.1001.0034.09 B ATOM 7997 N TTRB 424 -10.140-32.346-69.9961.0034.87 B

ATOM 7998 CA TYR B 434 -1023-32:574-70.9321.0034.62 B

ATOM 7999 CB TYR B- 424 -12.21:8-33.597-70.3761.0033.29 B

ATOM 8000 CG TYR B 424 -13.402-33.853-71.285 1.0031.12 B

ATOM 8001 CJDl TYR B 424 -13.232-34.463-72.5291.0029.85 B ATOM 8002 CEl TYRTB 424 -14.312-34.680-73.3801.0Θ 29.23 B

ATOM 8003 CD2TYRB424 -14.685-33.467-70.9091.0030.92 B

ATOM 8004 CE2 TYR B 424 -15.770-33.677-71.7471.0031.92 B

ATOM 8005 CZ TYR B 424 -15.580-34.285-72.9851.0030.59 B

ATOM 8006 OH TYR B 424 -16.668 -34.487 -73.807 LOO 29.32 B ATOM 8007 C TYR B 424 -11.956-31.283-71,2291.0035.02 B

ATOM 8ΘG8 O TYRB424 -12.002-30,835-72.3741.0036.35 &

ATOM 8009 N^" LEU B 425^" -12.530 -30.687 -70.1961.0035.01 B

ATOM 80-10 CAJLEU B 425 -13,2*1-29:453 -70.3691.0035.3S B

ATOM 8011 CB LEU B 425- -13.785 -28.95-3-69^0171.0037.4-8 B ATOM ^"8Θ12 CG LEUB-425 -14,897-29.805-68.4151.00-37.05 B

ATOM ^8013 CDl LEU B.425 -153-15 -29.248 -6-7.081 1.0038.56 B

ATOM 8014 CD2XEUB425 -1-6.072 -29:810-69:3651.0036.72 B

ATOM 8015 C LElTB 425 -12.519-28.341 -71.0761.0034.49 B

ATOM 8016 O LEUB 425 43.086 -27.661 -71.9261.0033.99 B ATOM 8017 N LEUB 426 -11.246-28.143-70.7321.0033.40, B

ATOM 8018 CA LEU B 426 -10.479-27.090-71.3891.0032.55 B

ATOM 8019 CB LEU B 426 -9.027-27.031-70.9071.0031.03 B

ATOM 8020 CG LEU B 426 -8302 -25.918 -71.6841.0029.78 B

ATOM 8021 CDl LEU B 426 -8.820-24.575-71.1941.0027.95 B _6ly

ATOM 8022 CD2LEUB426 -6.799-26.004-71.523 1.0029.05 B

ATOM 8023 C LEU B 426 -10.467-27.376-72.8791.0032.52 B

ATOM 8024 O LEUB 426 -10.743-26.493-73.7041.0031.88 B

ATOM 8025 N LYS B 427 -10.144-28.626-73.2171.0032.14 B ATOM 8026 CA LYS B 427 -l-Grl03-29.fl24---74.621 1.0030.63 B

ATOM 8027 CB LYS B 427 -9.848 -30.493 -74.785 1.0029.19' B

ATOM 8028 CG LYS B 427 -9.288-30.733-76.1271.0028.16 B

ATOM 8029 CD LYS B 427 -8.982-32.166-76.3110.0028.50 B

ATOM 8030 CE LYS B 427 -9.806 -32.723 -77.446 D.0028.40 B ATOM 8031 NZ LYS B 427 -11.098 -33.308 -76.9960.0028.34 B

ATOM 8032 C LYS B^~427 -11.413-28.723-75.2941.0030.2T B-

ATOM 8033 O LYS B 427 -11.481-28.215-7^4071.0030.12 B

ATOM 8034 N MET B 428 -12.478-29.060-74.6141.0029.28 B

ATOM 8035 CA MET B 428 -13.743-28.756-75.1961.0030.06 B ATOM 8036 CB MET B 428 -14.845-29.292 -74308^" 1,0030.96 B

ATOM 8037 CG MET B 428 -15.800-30.111-75.0721.0031.63 B

ATOM 8038 SD METB 428 -15.085-31.3-91-76.0801.0033.07 B

ATOM 8039 CE MET B 428 -16.499-31.733-76.8421.0032.02 B

ATOM 8040 C MET B 428 -13.843-27.245-75.323 1.0030.16 B ATOM 8041 O MET B 428 -14.369-26.710-76.295 1.0030.86 B

ATOM 8042 N ALAB 429 -13305-26.554-74.329 ITOO 30.18 B

ATOM 8943 CA ALA B 429 -13.369 -.25.095 -74.3241.00:29.75 B

ATOM 8044 CB-ALA B-429 -12.736-24.537-73.0501.0028.84 B-

ATOM- £045^~C ALA B 429 --O.665--J24.530 -75.541 h0029.1-0 B ATOM 8046 O ALA B 429 -13.1S6--23.6-48 -76.2391.00:27.33. B

ATOM 804-7 N ^"LEU B 430^" -11.4X0-25.074 -75.7871.00-28:95 B

ATOM -8048 CA EEU B^~430 -10;641--24.672_^76.8971.0060.18 B

ATOM 8049 CB XEU B 430 -9.354 -25τ483 -76.885 1.0028.10 B

ATOM 8050 CG LEU B 430 -8.303 -25.213 -75.8181.Θ027.94 B ATOM 8051 CDl LEUB 430 -7:063-26.036-76.118 1.0027.48 B

ATOM 8052 CD2 LEU B 430 -7.945-23.742-75.815 1.0027.57 B

ATOM 8053 C LEUB 430 -11.297-24.867-78.2571.0031.93 B

ATOM 8054 O LEUB 430 -10.846-24.341-79.278 1.0032.62 B

ATOM 8055 N GLUB 431 -12.368-25.629-78.271 1.0032.20 B _m

ATOM 8056 CA GLUB 431 -13.009-25.913-79.521 1.0032.58 B

ATOM 8057 CB GLUB 431 -13.088-27.407-79.635 1.0034.24 B

ATOM 8058 CG GLU B 431 -14.041-27.939-80.611 1.0037.60 B

ATOM 8059 CD GLUB 431 -14-231-29.413-80.383 1.0039.86 B ATOM 8060 OEl GLUB 431 -13.360-30.009-79.6971.00-3^77 B

ATOM 8061 OE2GLUB431 -15.237-29.962-80.885 1.0041.54 B

ATOM 8062 C GLUB 431 -14.367-25.284-79.5861.0032.59 B

ATOM 8063 O GLUB 431 -14.809-24.816-80.625 1.0033.76 B

ATOM 8064 N EYS B 432^" -15.030 -25.24^'8-78.4521.0033.76 B ATOM 8065 CA LYS B 432 -16.355 -24.676 -78.420 IJOO 34.88 B

ATOM 8066 CB LYS B 432 -17^45-25.476-77^671.0033.05 B

ATOM 8067 CG LYS B^" 432 -17.398 -26.941 -77.849 L0036J2 B

ATOM 8068 CD LYS B 432 -18.136-27.109-79.151 1.0035.97 B

ATOM 8069 CE LYS B 432 -18.214-28.577-79.5381.0038.08 -B ATOM 8070 NZ LYS B 432 -19.021-28.774-80.7841.0038.61 B

ATOM 8071 C LYS B 432 -16.341-23.211-78.0261.0034.74 B

ATOM 8072 O LYS B 432 -16.804-22.354-78.7821.0035.29 B

ATOM 8073 N ELE B 433 -15.788-22.908-76.863 1.0033.82 B

ATOM 8074 CA ILE B 433 -15.794-21.528-76.4271.0033.68 B ATOM 8075 CB ILE B 433 -15.363 -21.422 -74.940 LOO 34.06 B

ATOM- 8076 CG2 ILE B 433 -15.092 -1-9.971 -74.555 1.09-3IL37 B

ATOM 8077 CGl TLE B 433 46.494-21.951 -74J)561.0033.29 Η

ATOM 8878r CDl-TLE B 433 -16. l-UL-22.125 -72.622 LOO 34.52 B

ATΘM- 8079 C ELEBL433 -14?984 -2O3S0 -77.3101.0033.18 .B~ ATOM 8080-Q ILEB433 -15.464 -49.498" -77.656 LOO 34.23 B-

ATOM 8081 N AL&rB,434 -13.777-20.978 -77.700 TOθ-θl.m B

ATOM 8082 CA- ALA B 434 -1-2.936 -2θrl2T -78.5421.0029:87 B

ATOM 8053. CB ALA B-434 -11.674-20:88.0-78:933 1.0028.78 B-

ATOM 8Θ84 C ALA.R434 -13.654-19.598-79.8061.0028.98 B ATOM 8085 O ALA B 434 -13.396-18.477-80.283 1.0028778 B

ATOM 8086 N PHE B 435 -14.546-20.422-80.328 1.0026.84 B

ATOM 8087 CA PHE B 435 -15.273-20.109-81.5341.0025.75 B

ATOM 8088 CB PHE B 435 -16.122-21.300-81.933 1.0025.49 B

ATOM 8089 CG PHE B 435 -16.831-21.107-83.242 1.0023.10 B ^

ATOM 8090 CDl PHE B 435 -16.206-21.493-84.4151.0021.06 B

ATOM 8091 CD2PHEB435 -18.125-20.575-83.3021.0022.98 B

ATOM 8092 CEl PHE B 435 -16.833-21.367-85.654 1.0020.91 B

ATOM 8093 CE2PHEB435 -18.790-20.430-84.544 LOO 22-51 B ATOM 8094 CZ PHE B 435 -18.133-20.842-85.7361.0020.85 B

ATOM 8095 C PHE B 435 -16.236-18.952-81.530 LOG 25.45 B

ATOM 8096 O PHE B 435 -16.327-18.164-82.4701.0027.28 B

ATOM 8097 N LEUB 436 -17.022-18.924-80.4691.0025.43 B

ATOM 8098 CA LEUB 436 -18.122-17.958-80.3651.0024.79 B ATOM 8099 CB LEU B 436 -18.652-17.862-78.963 1.0025.37 B

ATOM 8100 CG LEU B 436 -19.004-19:080-78.140 1.0026.31 B

ATOM 8101 -CDl LEUB 436 -18.756.-18.628-76.728 1.0027.20 B

ATOM 8102 CD2 LEUB 436 -20.454-19.544-78.2661.0025.73 B

ATOM 8103 C LEU-B 436 -17.952-16.552-80.8501.0024.86 B ATOM 8104 O LEUB 436 - 18.847-16.007 -8Ϊ.494 1.0023.58 B

ATOM 8105 N ERO B 437 -16.858-15.896-80.453 1.0024.50 B

ATOM 8106 CD PRO B 437 -15.973-1.6.266-79.344 1.0024.01 B

ATOM 8107 CA PRO B 437 -16.603-14.524-80.8821.0024.63 B

ATOM 8108 CB PRO B 437 -15,291-14.178-80.1671.0024.04 B ATOM 8109 CG PRO B 437 -14.725-15.548-79.7121.0024.90 B

ATOM 8110 C PRO B 437 -16.510 -14.489 -82.39S 1.0024.82 B-

ATOM 8-1M O PRO B 437 -17.08743.623-83,031 1.0025.40 B

ATOM 8112 N PHE-B 438 -15.825-15.468-82.979 1,0624.15 B

ATOM 81-13 -CA PHE B 438 -15.678 -15.495 -84.424.1.0024-89 ^~B^~ ATOM 81-14 CB -PHE B 438 -.L4.579 -16.482-84.871- 1.0026.13 B

ATOM 8115 CG PHE B 438 -14,434 -16.586 -8&381- 1:0027.43 B

ATOM 811-6 CDl PHE B 438 -14.037 -157486 -877115 1.0027.56 B-

ATQM 8117 CD2 PHE B 438 -14.708-177779-87.0441.0028.35 B-

ATOM 8118 CEl PHE B-438 -13.912 -15.572 -88L529 1.0028.42 B ATOM 8119 CE2 PHE B 438 -14.586 -17.871 -8&443 1.0029.06 B

ATOM 8120 CZ PHEB 438 -14.186-16.763-89.1821.0027.63 B

ATOM 8121 C PHE B 438 -16.971-15.830-85.1481.0023.38 B

ATOM 8122 O PHE B 438 -17.254-15.277-86.2091.0023.91 B

ATOM 8123 N GLYB 439 -17.747-16.735-84.572 1.0021.26 B _m

ATOM 8124 CA GLY B 439 -18.991-17.133-85.1941.0019.53 B

ATOM 8125 C GLY B 439 -20.076-16.092-85.0471.0019.17 B

ATOM 81260 GLYB 439 -21.152-16.222-85.605 1.0020.76 B

ATOM 8127 N TYRB 440 -19.792-15.041-84.300 1.0018.91 B ATOM 8128^" CA ΕYR B 440 -20.775-13.987-84.0761.0018.78 B

ATOM 8129 CB TYKB 440 -20.816-13.652-82.575 1.0016.19 B

ATOM 8130 CG TYRB 440 -21.637-12.438-82.193 1.0012.19 B ATOM 8131 CDl TYRB 440 -23.022-12.506-82.120 1.0011.52 B

ATOM 8132 CEITYRB^'440 -23,780 -11.392 -81.7851.G09.97 B ATOM 8133 CD2 TYRB 44O -21.027-11.218-81.9181.0012.0.7 B

ATOM -8134 CE2 TYR B-440 -217778 -10:096 -81-.5841.001O.64 B

ATOM 8135 CZ TYR B-440 -23.150-10.190-81.5221.0010.44 B

ATOM 8136 OH TYR B 440 -23.894 -9.075-81.228 1.0010.52 B

ATOM 8137 C TYR B 440 -20.312-12.777-84.8501.0019.52 B ATOM 8138 O TYRrB 440 -21.095-11.921-85.253 1.0019.75 B

ATOM 8139 N LEU B 441 -19.0Q4 -12.732 -85.0341.0021.68 B

ATOM 8140 CA LEUB 441 -18.314-11.646-85.701 1.0023.31 B

ATOM 8141 CB LEUB 441 -16.832 -11-.786 -85.3291.0023.63 B

ATOM 8142 CG LEUB 441 -15.559-11.488-86.1121.0025.20 B ATOM 8143 CDl LEUB 441 -14.415-12.070-85.2761.0023.68 B

ATOM. 8144 CD2JLELTB 44-1 -15.557 -12.114 -87.50Θ 1.0022.81 B

ATOM 8145- σ LEU B 441^" -1-8.555 -11.627 -87.2071.0023.96 M

ATOM M46 O JtEUB 441 -19-0J57 -10r646 -87.7501.0023.83 B

ATOM 8 R7- N VAL B 442- -1-8.228 -12.737 -.87:85.91.00-24.97 B^* ATOM 8448- CA VAL & 442 -18^62-12.889-89.3071.0026.58 B

ATOM -.8149 CB VAL B 442 -1-8.336-1-4:370-8^7161.O02&78 B ATOM 8150- CGLVAL B 442 -1-8.551 -14V495-9T.2181.0027.58 B ATOM 8151 CG2VALB442 -17:0.05-14.994-89.3241.0026.92 B

ATOM 8152 C VALJB 442 -1-9.569 -12.267 -89.993 1.0027.65 B ATOM 8153 O VAL B 442 -19.431-11.428-90.8821.0028.39 B

ATOM 8154 N ASP B 443 -20.758-12.695-89.6071.0029.08 B

ATOM 8155 CA ASP B 443 -21.944-12.163-90.2491.0030.69 B

ATOM 8156 CB ASP B 443 -23.115-13.093-90.0591.0031.66 B

ATOM 8157 CG ASP B 443 -23.369-13.917-91.2661.0030.76 B _m

ATOM 8158 ODl ASP B 443 -22.427-14.631-91.701 1.0028.61 B

ATOM 8159 OD2ASPB443 -24.517-13.817-91.749 1.0031.75 B

ATOM 8160 C ASP B 443 -22.394-10.777-89.9181.0031.35 B

ATOM 8161 O ASP B 443 -23.290-10.256-90.5761.003239 B ATOM «162 N ALAB 444 -21.8-19-- IU 155 -88.9071.0031.54 B

ATOM 8163 CA ALA B 444- -22.270 -8.810-88,6401.00^"3L35- B

ATOM 8164 CB ALA B 444 -22.191 -8.467-87.133 1.0032.36 B

ATOM 8165 C ALA B 444 -21.340 -7.975-89.469 1.0029.92 B

ATOM 8166 O ALA B 444 -21.527 -6,781 -89τ6061.0029.77 B ATOM 8167 N TRP B 445 -20.327 -8.624-90.0251.0028.78 B

ATOM 8168 CA TRP B 445 -19.416 -7.942^90.921 1.002835 B-

ATOM 8169 CB TREB 445 -1-8 J42 -8.753 -91.1871.0027.63 B

ATOM 8170 CG TRPB 445 -17.245 -8.121-92.2341.0027.61 B

ATOM 8171 CD2TRPB445 -17.145- -8L500 -93.6121.0027.55 B ATOM 8172 CE2 TRPB 445 -16.249 -7:600 -94:231 1.002(5.71 B

ATOM 8173 CE3TRPB445 -17.729 -9.512-94.3841.0027.44 B

ATOM 8174 CDl TRP B 445 -16.421 -7.036-92.0791.0027.03 B

ATOM 8175 NEl TRP B 445 -15.822 -6.719-93.2741.0026.02 B

ATOM 8176 CZ2TRPB445 -15.925 -7.684-95.5821.0026.57 B ATOM 8177 CZ3 TRPB 445 -17.407 -9.595-95.7221.0027.37 B

ATOM 8178 CH2 TRP B 445 - 16.5 Ll -8.685 -96.3T0 LOO 27.49 B

ATOM 8179 C TRP B 445 -20.216 -^.861 -92.217170028.-10 B

ATOM 8L80 O J3UP-B44-5 -20.450^*-6.776 -92.758- 1.0028.0Z B

ATOM- 8181^~N ARGB 446 -20.673 -9.022-92.6841:0027.92 B- ATOM 81-82 CA ARG B 446 -217446 -9:104 -93.925 1.00:28.22 B

ATOM 81-8-3 CB ARGB 4T6 -21.71-9-10.564-94.3191.00_^26:93 B

ATOM 8184 CG ARG B 446 -20.529-11.241-94.-978 1.0026.39 B

ATOM 8185 CD JkRG-B 446 -20.877-12.547-95.6701.0025.54- B

ATOM 8186 NE ARG B 446 -21.443-13.534-94.765 1.00-26.51 B ATOM 8187 CZ ARGB 446 -21.274-14.847-94.9001.0028.04 B

ATOM 8188 NHl ARG B 446 -20.552-15.331-95.8961.0028.97 B

ATOM 8189 NH2 ARG B 446 -21.838-15.687-94.0461.0028.42 B

ATOM 8190 C ARG B 446 -22.754 -8.332-93.9491.0028.10 B

ATOM 8191 O ARG B 446 -23.181 -7.886-95.011 1.0029.58 B ATOM 8192 N TRP B 447 -23.413 -8.177-92.8091.0027.47 B

ATOM 8193 CA TRP B 447 -24.652 -7.411-92.822 1.0027.09 B

ATOM 8194 CB TRPB 447 -25.392 -7.516-91.4771.0030.41 B

ATOM 8195 CG TRP B 447 -25.509 -8.905 -91.1061.0033.86 B ATOM 8196 CD2 TRP B 447 -26.144 -9.3-80-89.7981.0036:09 B

ATOM 8197 CE2TRPB447 -26.467-10.748-89.921 1.0036.50 B

ATOM 8198 CE3 TRP B 447 -26.199 -8.783-88.5321.0038.05 B

ATOM 8199 CDl TRPB 447 -25.946 -9.968-91.9421.0034.58 B

ATOM 8200 NET TRP B 447 -26.339-11.084-91.2401.0035.57 B ATOM 8201 CZ2TRPB447 -26.840 -1L530 -88.8291.0037.81 B

ATOM 8202 CZ3TRPB447- -26.571 -9.563-87.441 1.003871-8 B

ATOM 8203 CH2 TRPB 447 -26,886-10.922-87.599 L0038J2 B

ATOM 8204 C TRP B 447 -24.292 -5.953-93.0891.0025.01 B

ATOM 8205 O TRP B 447 -25.074 -5.206-93.6661.0021.75 -B ATOM 8206 N GLY B 448 -23.086 -5.574-92.669 1.0024.18 B

ATOM 8207 CA GLY B- 448 -22.629 -4.201-92.8191.0024.09 B

ATOM 8208 C GLY B 448 -22.315 -3.868-94.248 1.0023.45 B

ATOM 8209 O GLY B 448 -22.481 -2.736-94.711 1.0023.05 B

ATOM 8210 N VAL B 449 -21.853 -4.907-94.925 1.0023.12 B ATOM 8211 CA VAL B 449 -21.506 -4.866-96.3221.0021.16 B

ATOM 8212 CB VAL B 449 -20.701 --6.112 -96.6241.00-21.77 B

ATOM- 8213 CGl VAL B 449 -20.594 -6338 -98J28 1.0021.10 ^~B

ATOM 8214 CG2 VAL B 449 -19332 -5.973 -95.9SS LQO 2O.#8^{^} B

ATOM 8215 C VALB1449 -22.790 -47820-97.1091.0015,65 _B^~ ATOM 8216-0 VAtB 449 -23.048 -3.887-97.8401.0019:35 B-

ATOM^" 8217 N PH&B^SΘ -23.623-5.824 -96.9-15 LOO 18.54 B-

ATOM 821-8 CA PHEΕ 450 -24.903 -5τ832 -97.594^" 1.0018.03 -B

ATOM 82-19 CB PHEB-450 -25.729 -7.044 -97. ML 1.0016.53 B

ATOM 8220 CG PHE B 450 -25.237 -8.357 -97.690.1.0017.14 B ATOM 8221 CDl PHE B 450 -25.327 -9.522 -96.9361.0016.57 B

ATOM 8222 CD2PHEB450 -24.723 -8.440-98.9861.0017.94 B

ATOM 8223 CEl PHE B 450 -24.914-10.751-97.4631.0016.47 B

ATOM 8224 CE2 PHE B 450 -24.308 -9.664-99.5261.0016.59 B

ATOM 8225 CZ PHE B 450 -24.405-10.819-98.765 1.0016.19 B __.

623

ATOM 8226 C PHE B 450 -25.688 -4.532 -97.331 1.00 18.27 B

ATOM 8227 0 PHE B 450 -26.480 -4.108 -98.159 1.00 17.78 B

ATOM 8228 N ALA B 451 -25.442 -3.890 -96.196 1.00 20.59 B

ATOM 8229 CA ALA B 451 -26.164 -2.670 -95.828 LOO 22.16 B ATOM 8230 CB ALAB 451 -26.322 -2.608 -94.313 1.0023.27 B

ATOM 8231 C ALA B 451 -25.521 -1.382 -96.335 1.0022.89 B

ATOM 8232 O ALA B 451 -26.155 -0.318 -96.358 1.0021.86 B

ATOM 8233 N GLY B 452 -24.249 -1.487 -96.709 1.0023.51 B

ATOM 8234 CA GLY^~B 452 -23.539 -0.342 -97.245 1.0026.27 B ATOM ^"8235 C GLY B 452 -22.743 0.434 -96.229 1.00 28.57 B

ATOM 8236 O GLY B 452 -22.056 1.412 -96.539 h00 29.16 B

ATOM 8237 N ARGB 453 -22.843 0.009 -94.984 1.0031.09 ^"B

ATOM 8238 CA ARG B 453 -22.101 0.710 -93.973 1.00 31.94 B

ATOM 8239 CB ARG B 453 -22.720 0.453 -92.621 1.00 35.39 B ATOM 8240 CG ARGB 453 -23.723 1.566 -92.378 1.00 39.90 B

ATOM 8241 CD ARG B 453 -25.150 1.103 -92.266 1.0042.86 B

ATOM 8242 NE ARG B 453 -26.053 2.253 -92.263 1.00 45.10 B

ATOM 8243 CZ ARG B 453 -27.260 2.254 -91.708 1.00 46.20 B

ATOM 8244 NHl ARG B 453 -27.689 1.157 -91.111 1.0045.68 B ATOM 8245 NH2 ARG B 453 -28.030 3.341 -91.750 1.0046.35 B

ATOM 8246 C ARGΗ 453 -20,627 0.390 -94.046 1.00 30.62 B-

ATOM S247 O ARGB^'453 -19.771 1.213 -93τ712 1.00 30.49 B

ATOM 8248 N THR-B 454 -,20.341- -5.804 -94.531 LOO'29.31- B

ATOM 8249 CA THR B454- -18.980 -1.221 -94.747 1.002S-90 3^" ATOM 825.0_CB -THR B-454 -18.669 -2.581^=94.095 1.0029.00 B

ATOM 8251 QGl THR B-454 -L8.810 -2.498 -92=467 1.0028:05 B

ATOM 8252 CG2 THRB 454 -17.25O- -2T983 -94.428 1.0029.80 B

ATOM- 8253 -C THR B 454 -18.887 -1.362 -96.271 1,00 29.03 B-

ATOM 8254 O THRB-454 -19.242 -2.404 -96.SZ4 1.00 31.15 B ATOM 8255 N PRO B 455 -18.465 -0,293 -96.9-68 1.00-27.39 B

ATOM 8256 CD PRO B 455 -18.318 1.058 -96.401 1.00 27.69 B

ATOM 8257 CA PRO B 455 -18.311 -0.263 -98.429 1.0026.16 B

ATOM 8258 CB PRO B 455 -18.287 1.226 -98.740 1.00 26.84 B

ATOM 8259 CG PRO B 455 -17.641 1.802 -97.519 1.0026.75 B ,.„ oz4

ATOM 8260 C PRO B 455 -17.012 -0.964 -98.827 1.0025.11 B

ATOM 8261 O PRO B 455 -16.260 -1.408 -97.965 1.0027.57 B

ATOM 8262 N PRO B 456 -16.716 -1.072-100.125 1.0022.92 B

ATOM 8263 CD PRO B 456 -17.495 -0.978-101.370 1.00 22.30 B ATOM 8264 CA PRO B 456 -15.454 -1.769-100.354 1.00 21.07 B

ATOM 8265 CB PRO B 456 -15.436 -1.939-101.87J 1.00 21.25 B

ATOM 8266 CG PRO B 456 -16.873 -2.067-102.208 1.00 21.34 B

ATOM 8267 C PRO B 456 -14.236 -1.014 -99.821 1.00 19.75 B

ATOM 8268 0 PRO B 456 -13.196 -1.606 -99.544 1.00 19.52 B ATOM 8269 N SER B 457 -14.374 0.290 -99.646 1.00 18.19 B

ATOM 8270 CA SERB 457 -13.249 1.092 -99.193 1.00 17.57 B-

ATOM 8271 CB SER B 457 -13.533 2.586 -99.447 1.00 17.15 B

ATOM 8272 OG SER B 457 -14.432 3.172 -98.520 1.00 15.07 B

ATOM 8273 C .SER B 457 -12.868 0.852 -97.731 1.00 18.99 B ATOM^' 8274 O SER B 457 -11.911 1.440 -97223 1.00 19.95 B

ATOM 8275 N ARGB 458 -13.635 -0τ015-97.065 1.00 19.37 B

ATOM 8276 CA ARG B 458 -13.436 -0.398 -95,649 1.00 18.91 B

ATOM 8277 CB ARG B 458 -14.382 0.333 -94.733 1.00 17.47 B

ATOM 8278 CG- ARG B 458 -13.987 1.682 -94.430 1.00 16,79 B ATOM 8279 CD ARG B 458 -14.910 2.230 -93.423 1.00 13.45 B

ATOM 8280^" NE ARG B 458 -15.432 3.502 -93Jm 1.00 1L82 B

ATOM 8-281 -CZ ARG B 45.8 -16.720 3.75-1 -94.051 1.00 1-0,28 B

ATOM 8282 NHl ARGB 458- -17.585 2J799 -93.778. LOO 8.61 J3

ATOM 8283- SB2 ARG B 458 -17.B2 4.941 -94.476- 1.00 9;95 B ATOM 8284- C ARG-B 458 -13.73-5 -1859-9-5.418 1.0O--JL8L80 -B-

ATΘM 8285- 0 ARGB 458 -14.377 -2.209 -94.435 1.0018.99 B

ATOM 82-86-N

-13.287 -2.716 -96.314 1:00.17.72 B

ATOM 8287 CA TYRB 459 -13.554 -4.126 -96.156 1.00 16.97 B

ATOM 8288 CB TYR B 459 -13.365 -4.883-97.479 1.00 18.60 B ATOM 8289 CG TYRB 459 -14.590 -5.038 -98.344 1.00 18.17 B

ATOM 8290 CDl TYRB 459 -14.546 -5.838 -99.478 1.00 18.28 B

ATOM 8291 CEl TYRB 459 -15.662 -5.984-100.306 1.00 18.06 B

ATOM 8292 CD2 TYR B 459 -15.784 -4.378 -98.046 1.00 18.79 B

ATOM 8293 CE2 TYR B 459 -16.906 -4.513 -98.858 1.00 18.58 B ATOM 8294 CZ TYR B 459 -16.838 -5.322-99.9881.0019.11 B

ATOM 8295 OH TYRB 459 -17.952 -5.495-100.781 1.0019.92 B

ATOM 8296 C TYR B 459 -12.647 -4.736-95.1041.0016.53 B

ATOM 82970 TYRB 459 -13 J.09 -5.492-94.2541.0018.21 B ATOM 8298 N ASNB 460- -11.358 -4.410-95.1641.0013.67 B

ATOM 8299 CA ASN B 460 -10.387 -4.951-94.2201.0012.17 B

ATOM 8300 CB ASN B 460 -9.015 -5.033-94.8751.009.92 B

ATOM 8301 CG ASN B 460 -8.423 -6.422-94.8021.009.97 B

ATOM 8302 ΘD1 ASN B 460 -9.098 -7.415-95.1091.0011.28 B ATOM 8303 ND2 ASN B 460 -7.158 -6.510-94.395 1.0010.20 B

-ATOM 8304 C ASN B 460 -10.297 -4.159-92.912 1.0012.45 B

ATOM 8305 O ASN B 460 -9.934 -4.700-91.858 LOO 12.6S B

ATOM 8306 N PHE B 461 -10.633 -2.880-92.9991.0011.59 B

ATOM 8307 CA PHE B 461 -10.643 -1.987-91.851 1.0011.11 B ATOM 8308 CB PHE B 461 -10.969 -0.575-92.3371.0010.20 B

ATOM 8309 CG RHEB-461 -11.096 0.45O -91.2471.00 S.O6 B

ATOM 8310 CDl PHE B 461 -10.039 0.733-90.3961.007.57 B

ATOM 8311 CD2PHEB461 -12.254 1.199-91.131 1.008.86 B

ATOM 8312 CEl PHE B 461 -10.139 1.758-89.455 1.006.51 B ATOM 8313 CE2 PHE B 461 -12.353 2.220-90.1901.009.42 B

ATOM 8314 CZ PHEB 461 -11.292 ^"2.499 -89.355 1.006.98 B

ATOM 8315 C PHE3.461 -11.693 -2.454 -90.828 LOO 11.45 B

ATOM 8316.0 PHEB 461 -11.388 -2.583-89.633 1.0012.79 B

ATOM -8317 N- ASP-B-462. -12.915 -2-7J28-91.2971.0010.69 B ATOM 8318 CA ASP B 462 -13.997 -3.144-90.421 1.009.65 B^

ATOM- 8319- CB ASP B 462 -K-.361 -2J834 -91.046 LOO 8.87 B-

ATOM 8320 CG ASPHB 462 -15.729- -1.363_-90.947 LOO 10.25 B

ATOM 8321 ODl ASP B 462 -15.140 -0.658-90.1101.0012.71 B-

ATOM 8322 OD2 ASP B 462 -16.618 -0.895-91.6851.0010.71 B ATOM 8323 C ASP B 462 -13.916 -4.613-90.0701.009.90 B

ATOM 8324 O ASP B 462 -14.607 -5.074-89.1721.0010.30 B

ATOM 8325 N TRP B 463 -13.069 -5.350-90.7791.0010.85 B

ATOM 8326 CA TRP B 463 -12.911 -6.778-90.5181.0010.82 B

ATOM 8327 CB TRPB 463 -12.174 -7.462-91.6871.006.60 B ATOM 8328 CG TRP B 463 -11.847 -8.949-91.525 1.002.24 B

ATOM 8329 CD2TRPB463 -12.777-10.038-91.422 1.001.00 B

ATOM 8330 CE2 TRP B 463 -12.020-11.236-91.340 1.001.00 B

ATOM 8331 CE3 TRPB 463 -14.173-10.119-91.393 1.00 UA B ATQM 8332 CDl TRP B 463 -10.597 -9.518-91.5001.001.00 B-

ATOM- 8333 NEJTRPB46J -10.697-10.891-91.391 1.00 1.00 B

ATOM 8334 CZ2 TRP B 463 -12.613-12.493-91.2291.001.00 B

ATOM 8335 CZ3 TRPB 463 -14.762-11.376-91.2821.001.00 B

ATOM 8336 Cffi TRp-B 463 -13.976 -12.546 -91.201 1.00 1.00 B ATOM 8337 C TRP B 463 -12.092 -6.829-89-2551.0012.31 B

ATOM 833SO TRP B 463- -12.524 -7.384-88.261 1.0014.39 B

ATOM 8339 N TRPB464 -10.919 -6.215 -89.282 1.0013.9-7 B

ATOM 8340 CA TRPB 464 -10.077 -6.217-88.109 1.0015.84 B

ATOM 8341 CB TRP B 464 -8.669 -5.760-88.4991.0016.92 B -ATOM 8342 CG TRP B 464 -8.033 -6.773 -89:4261.0018.63 B

ATOM 8343 -CD2 TRP B 464 -7.526 -8.066-89,061 1.0018.56 B

ATOM 8344 CE2 TRP B 464 -7.190 -8.731-90.2571.0018.17 B

ATOM 8345 CE3 TRP B 464 -7.333 -8.729-87.8361.0018.64 B

ATOM 8346 CDl TRP B 464 -7.970 -6.712-90.7941.0018.34 B ATOM 8347 NEl TRP B 464 -7._468 -7.884-91.2961.0017.12 B

ATOM 8348- CZ2 TRP B 464 -6.67.2 -10.022 -90.268 1.0019-67 B

ATOM 8349 CZ3 TRP B 464 -6.821-10.009-87.849 1.0019.25- B-

ATOM -8350 CHZ-TRP-B 464 -6.496-10.645-89.061 1.0019.84 B

ATOM 8351- C TRP B 464 -U3;650 -5.430 -86v9-l-5- DlO 17.32 B -ATOM -8352 O TRP B 464 -10.269 -5.696-85.7701.0017:63^" B

ATOM 8353 N- PHRJB 465^" -11.553 -4.472.-87.1521.0017.56 -B

AXQM 8354 CA TYR B 465" -42.157 -3.777-86:0171.0017.31 B

ATOM 8355 CB TYR B 465 -13.174 -2.718 -S6.443 1,0016.68 B

ATOM 8356 CG-TYRB 465 -14.106 -2.288-85.315 1,0016.09 B ATOM 8357 CDl TYRB 465 -13.764 -1.258-84.4401.0015.26 B

ATOM 8358 CEl TYRB 465 -14.614 -0.891-83.3981.0015.31 B

ATOM 8359 CD2TYRB465 -15.323 -2.937-85.114 1.0015.98 B

ATOM 8360 CE2 TYRB 465 -16.175 -2.578-84.0771.0016.08 B

ATOM 8361 CZ TYR B 465 -15.816 -1.561-83.223 1.0014.98 B _62?

ATOM 8362 OH TYR B 465 -16.656 -1.235-82.192 1.0014.24 B

ATOM 8363 C TYR B 465 -12.903 -4.906-85.327 1.0017.91 B

ATOM 8364 O TYRB 465 -12.767 -5.122-84.1271.0020.45 B

ATOM 8365 N LEUB 466 -13.680 -5.649-86.105 1.0016.73 B ATOM 8366 CA LEU B^'46ό -14.454 -6.754-85.551 1.0015.95 B

ATOM 8367 CB LEU B 466 -15.457 -7.273 -86.584 1.0012.27 B

ATOM 8368 CG LEU B 466 -16.527 -6.248-86.964 1.0012.62 B

ATOM 8369 CDl LEU B 466 -17.332 -6.727-88.139 1.0013.39 B

ATOM 8370 CD2 LEU B-466 -17:431 -6.009-85.8021.0013.73 B ATOM 8371 C LEU B 466 -13.617 -7.911 -85.0J3 1.0016.17 B

ATOM 8372 O TJEU B 466 -13.953 -8:51-2-84.021 h0018.Θ6 B

ATOM 8373 N^" ARGB 467 -12.531 -8.226-85.720 1.0015-77 B

ATOM 8374 CA ARG B 467 -11.695 -9.336-85.314 1.0015.15 B

ATOM 8375 CB ARG B-467 -10.672 -9.649-86.4001.0013.73 B ATOM 8376 CG ARG B 467 -11.282 -10.268 -87.6521.0010.77 B

ATOM 8377 CD ARG B 467 -11.322-11.799-87.586 1.009.35 B

ATOM 8378 NE ARG B 467 -10.023-12.381-87.904 1.006.18 B

ATOM 8379 CZ ARG B 467 -9.776-13.680-87.936 1.005.10 B

ATOM 8380 NHl ARG B 467 -8.565 -14.111-88.243 1.006.30 B ATOM 8381 NH2 ARG B 467 -10.733-14.545-87.653 1.002.97 B

ATOM 8382 C ARGB 467 -11.009 -8τ994 -84:0221.0016.80 B

ATOM 8383 O ARG-B 467 -10.925 -9.822--S3.130 1.0019.19 B

ATOM- 83S4 N THRrB-468 -10.519 -7.770 -83:-9091.0017.47 B

ATOM 8385 CA THRlB-468 -9.861 -7.369-82.681- 1.0D-18.2L B ATOM 8386 CB THR-B-468 -9.012 -6.105 -82.8961.0018.35 B

ATOM 8387 GGl THR B 468 -7.881 -6:437 -83.7071.00 l-9r75 B

-ATOM 8388 CG2 THKB 468L -8.514 -5.550 -81.5701.0019.08 B

ATOM 8389 C THR B 463 -10327 -7.126-SkOIl 1.0018.21 B

ATOM 8390 O THR B 468 -10.761 -7.509--80.4541.0018.55 B ATOM 8391 N LYS B 469 -12.040 -6.525-82.008 1.0017.94 B

ATOM 8392 CA LYS B 469 -13.096 -6.252-81.0501.0017.69 B

ATOM 8393 CB LYS B 469 -14.272 -5.531-81.694 1.0017.39 B

ATOM 8394 CG LYS B 469 -15.495 -5.463-80.7771.0015.93 B

ATOM 8395 CD LYS B 469 -16.515 -4.481-81.308 1.0015.70 B _ffig

ATOM 8396 CE LYS B 469 -17.760 -4.498-80.4821.0014.28 B

ATOM 8397 NZ LYS B 469 -18.665 -3.386-80.878 1.0016.10 B

ATOM 8398 C LYS B 469 -13.632 -7.478 -80.361 1.0017.72 B

ATOM 8399 O LYS B 469 -13.901 -7.429-79.176 LOO 20.51 B ATOM 8400 N TYR B 470 -D.803 -8.575 -8-1.687^" LOO 16.97 B

ATOM 8401 CA TYRB 470 -14.337 -9.778 -80.476.1,00 Ϊ&42 B

ATOM 8402 CB TYR B 470 -15.442-10.358-81.3301.0014.53 B

ATOM 8403 CG TYRB 470 -16.686 -9.514-81.338 1.0014.21 B

ATOM 8404 CDl TYRB 470 -16.846 -8.464 -S2.2371.0Θ 15.2? B ATOM 8405 CEl TYRB 470 -18.000 -7.687-82.218.1.0015:28 B

ATOM 8406 CD2TYRB470 -17.702 -9.755-80.4341:0013.36 B

ATOM -8407 CE2TYRB470 -18.842 -8.S84 -80.4081.0012.62 B

ATOM 8408 CZ TYRB 470 -18.989 -7.956-81.291 1.0014.24 B

ATOM 8409 OH TYR B 470 -20.118 -7.181 -81.21-81.00- 16.73 B ATOM 8410 C TYRB 470 -13.331-10.868-80.149 1.0018.28 B

ATOM 8411 O TYR B 470 -13.201-11.258-78.991 1.0020.26 B-

ATOM 8412 N GLN B 471 -12.626-11.376-81.148 LOO 17.89 B

ATOM 8413 CA GLN B 471 -11.644-12.427-80.891 1.0018.49 B

ATOM 8414 CB GLN B 471 -11.126 -13.025 -82.195 1.0019.17 B ATOM 8415 CG GLN B 471 -12.047-14.007-82.8561.0020.51 B

ATOM 8416 CD GLN B 471 -11.431 -14_^582--84.Θ95 LOX) 20.23 B

ATOM 8417 OEl GLN B 471 -11.146-13.851 -8-5.050 Lθθ 21.58- B

ATOM 8415 NE2-GLN B 471 -11.2-00 -15.893 -#4τG92 LOO 17.72 B

ATOM :8iH 9 C GLNB 471 -10.435 -11.942-80.1!05"LOO 18.59 B AT©M 8420 O GLN-B 471 -9.758 -12.744 -797445 iτOO 19.35 B:

ATOMr .8421 N -GLY-B 472 -10.148 -107644-8fl.r93 1.0016.68 B

ATOM 8422 CA GLY B^' 4-72 -8.993 -10.115-79:500 U0.0_15.88 B

ATOM 8423 C GLY B 472^" -7.710-10.660-80.091 1.0015.90 B

ATOM 84240 GLY B 472 -6.778--11.044 -79.366 LOO 13.76 B ATOM 8425 N ILE B 473 -7.681 -10.731 -81.423 1.0016.35 B

ATOM 8426 CA ILE B 473 -6.498-11.188-82.1391.0015.07 B

ATOM 8427 CB ILE B 473 -6.737-12.499-82.851 1.0015.51 B

ATOM 8428 CG2 ILE B 473 -7.143-13.561-81.842 1.0015.44 B

ATOM 8429 CGl ILE B 473 -7.801-12.316-83.9241.0016.05 B ATOM 8430 CDl ILE B 473 -7.915 -13.512 -84.850 1.00 18.20 B

ATOM 8431 C ILE B 473 -6.107 -10.136 -83.157 1.00 14.70 B

ATOM 8432 O ELE B 473 -6.859 -9.201 -83.410 1.00 12.10 B

ATOM 8433 N CYS B 474 -4.927 -10.292 -83.742 1.00 16.48 B

ATOM 8434 CA CYS B-474 -4.442 -9.323 -84.714 1.00 17.71 B

ATOM 8435 CB CYS B 474 -3.744 -8.193 -83.972 1.00 18.07 B

ATOM 8436 SG CYS B 474 -2.212 -8.726 -83.184 1.0020.09 B

ATOM 8437 C CYS B 474 -3.483 -9.902 -85.764 1.00 17.70 B

ATOM 8438 O CYS B 474 -2.7515 -10.860 -85.507 1.00 17.70 B

ATOM 8439 N PRO B 475 -3.465 -9.306 -86.962 1.00 17.89 B

ATOM 8440 CD PRO B 475 -4.305 -8.166-87.362 1.00 17.90 B

ATOM -8441 CA PRO B 475 -2.604 -9.747 -88.062 1.00 17.02 B

ATOM 8442 CB PRO B 475 -3.037 -8.842 -89.217 1.00 18.67 B

ATOM 8443 CG PRO B 475 -3.547 -7.600 -88.514 1.00 18.70 B

ATOM 8444 C PRO B 475 -1.135 -9.605 -87.698 1.00 16.05 B

ATOM 8445 O PRO B 475 -0.700 -8.549 -87.231 1.00 14.46 B

ATOM 8446 N PRO B 476 -0.358 -10.681 -87.899 1.00 15.95 B

ATOM 8447 CD PRO B 476 -0.865 -11.943 -88.480 1.00 15.73 B

ATOM 8448 CA PRO B 476 1.085 -10.772 -87.615 1.00 15.07 B

ATOM 8449 CB PRO B 476 1.346 -12.265 -87.662 1.00 15.45 B

ATOM 8450 CG PRO B 476 0.405 -12.724 -88.746 IvOO 17.46 B.

ATOM 8451 C PRO & 476 1.881 -10:074 -88.670 1.00 14.61 B

ATOM 8452 O PRO B 476 3.098 -10.212 -88:748 l.θθ 14.00 J8

ATOM- .8453 N. VAL.&-477 1.167 -9.267 -89.444 1.00 14.82 B

ATOM 8454 CA YALE 477. 1.763 -8.60-1 -9-0.574 1.00 1432 JB

ATOM 8455- CB VAL B 47-7 1.819 -9.732 -9-L645 1.00 L5.30 B-

ATOM 8456 CGl VAL B 477 0.546 -9.732 -92.477 1.00 16.78 B

ATOM 8457 CG2 VAL B 477 3.078- -9.686 -92.424 1.00 15.89 B

ATOM 8458 C VAL B 477 0.890 -7.358 -90.954 1.00 13.07 B

ATOM 8459 O VAL B 477 -0.332 -7.404 -90.843 1.00 12.31 B

ATOM 8460 N THRB 478 1.483 -6.240 -91.372 1.00 11.02 B

ATOM 8461 CA THRB 478 0.633 -5.086 -91.692 1.00 9.02 B

ATOM 8462 CB THR B 478 1.450 -3.873 -92.188 1.00 8.65 B

ATOM 8463 OGl THR B 478 2.386 -3.475 -91.189 1.00 11.08 B _m

ATOM 8464 CG2THRB478 0.532 -2.712-92.4621.006.02 B

ATOM 8465 C THR B 478 -0.379 -5.463-92.7701.008.96 B

ATOM 8466 O THR B 478 -0.077 -6.288-93.633 1.009.75 B

ATOM 8467 N ARG B 479 -1.572 -4.S68 -92.7171.007.90 B ATOM 8468 CA ARG B 479 -2.610 -5.144 -93.705 1.009.39 B

ATOM 8469 CB ARG B 479 -3.658 -6.099-93.135 1.007.72 B

ATOM 8470 CG ARG B 479 -3.067 -7.248-92.3541.008.20 B

ATOM 8471 CD ARG B 479 -2.291 -8.147-93.2241.007.53 B

ATOM 8472 ΗE ARG B 479 -3.159 -8.787-94.201 1.009.07 B ATOM 8473 CZ ARGF479 -2.724 -9.311-95.3391.006.98 B

ATOM 8474 NHl ARG B 479- -1.434 -9.268 -95.6541.007.74 B

ATOM 8475 NH2 ARG B 479 -3.577-9.895-96.1471.005.52 B

ATOM 8476 C ARGB 479 -3.319 -3.870-94.191 1.0011.44 B

ATOM 8477 O ARGB 479 -3.859 -3.124-93.383 1.0012.74 B ATOM 8478 N ASN B 480 -3.311 -3.640-95.5101.0012.94 B

ATOM 8479 CA ASN B 480 -3.981 -2.487-96.1351.0013.94 B

ATOM 8480 CB ASNB 480. -3.190 -1.931-97.2961.0016.63 B

ATOM 8481 CG ASN B 480 -1.769 -2.242-97.203 1.0021.39 B

ATOM 8482 ODl ASN B 480 -1.010 -1.724-96.3561.0024.90 B ATOM 8483 ND2 ASN B 480 -1.367 -3.121-98.0821.0020.28 B

ATOM 8484 C ASNB 480 -5.327 -2.838-96.7081.0014.17 B

ATOM 8485 O ASN B 480 -5.736 -3.983 -96.723.1.0014.02 B^~

A-TOM 8486 N GLU B 481- -6.009 -1.832-97.2291.0015.62 B

ATOM 8487 CA GLUB 481 -TJLM -2J)72-97J8tt2 T.θθ 15.81 B ATOM 8488 CB GLUB 481 -8.115 -0.772-97.898 IJ)O 15.49 B

ATOM- 8489-CG GLU B-48I -9.602 -1.014-97.8781.0.01-&87 B

ATOM 849© CD GLU B 481 -10.075 -1.563 -96.548 1.001-8.51 B

ATOM 8491 OEl GLUB 481 -9.914 -0.858-95.5401.0020.66 B

ATOM 8492 OE2 GLU B 481 -10.609 -2.690-96.501 1.0018.67 B ATOM 8493 C GLU B 481 -7.189 -2.725-99.203 1.0016.12 B

ATOM 84940 GLUB 481 -8.190 -2.898-99.901 1.0016.49 B

ATOM 8495 N THR B 482 -5.969 -3.071-99.625 1.0014.70 B

ATOM 8496 CA THR B 482 -5.829 -3.742-100.9161.0013.52 B

ATOM 8497 CB THRB 482 -4.464 -3.442-101.6391.0014.10 B _m

ATOM 8498 OGl THRB 482 -3.470 -4.396-101.260 1.0013.63 B

ATOM 8499 CG2 THR B 482 -3.986 -2.055-101.313 1.0014.07 B

ATOM 8500 C THR B 482 -5.956 -5.225-100.601 1.0012.40 B

ATOM 850-1 O THRB 482 -5.955 -6.080-10L4821.0012.07 B ATOM 8502 N HIS B 483 -6.075 -5.508-99.3061.0011.64 B

ATOM 8503- CA HISΕ 483 -6.247 -6.862-98.805 1.009.40 B

ATOM 8504 CB HIS B 483 -5.513 -7.042-97.4971.0010.34 B

ATOM 8505 CG HIS B 483 -4.027 -6.945-97.6161.0011.88 B

ATOM 8506 CDZ HIS B 483 -3.156 -7.528-98.471 1.0012.72 B ATOM 8507 TSIDlHIS B 483 -3.266 -6.208 -96.7391..0012.69 B

ATOM S508 CEl HES-B 483 -h989 -6.339 -97.0461.0013.00 B

ATOM 8509 NE2 HIS B 48? -1.894 -7.136-98.093 1.0014.49 B

ATOM 8510 C HIS B 483 -7.726 -7.148-98.5871.009.29 B

ATOM 8511 O HIS B 483 -8.549 -6.234-98.483 1.007.69 B ATOM 8512 N THEB484 -8.055 -8.430-98.5181.009:68 B

ATOM 8513 CA PHE B 484 -9.424 -8.847-98.331 1.0011.24 B

ATOM 8514 CB PHE B 484 -10.086 -9.105-99.679 1.0015.27 B

ATOM 8515 CG PHE B 484 -11.563 -9.370-99.586 1.0018.23 B

ATOM 8516 CDl PHE B 484 -12.172-10.335-100.4021.0017.97 B ATOM 8517 CD2 PHE B 484 -12.348 -S.642 -98.6981.0017.09 B

ATOM 85 IS CEl PHE B 484 -1-3.542 -10.565-100.331 1.0018.75 B

ATOM^" 8519 CE2THE-B 434 -13.71-0 -O65 -98.621 1.(10.1-8.71 B

ATOM 8520 CZ PHE B 48.4 -14.313 -9.832-99.443 1.0019.35 B

ATOM" 8521 C PHE B 484 -9.363-10:i29 -97.5341.00-11.99 B ATOM 8522 O- -PHE:B-484 -9.655-11.220-98.0421.0011.29 B

ATOM 8523 N ASP-B 485 -8:994- -9:985 -96:265 1.0012.10 B^"

ATΘM _8524 CA ASP B 485 -8τ858 -11130-95.3871.0010.66 B

ATOM 8525 CB ASP B 485. -8.129-10.697-94.129 LOO 9.65 B

ATOM 8526 CG ASP B- 485 -6.736-10.190-94.425 1.0010.06 B ATOM 8527 ODl ASP B 485 -6.003-10.880-95.171 1.007.73 B

ATOM 8528 OD2 ASP B 485 -6.370 -9.112-93.9071.0011.79 B

ATOM 8529 C ASP B 485 -10.173-11.843-95.0741.009.83 B

ATOM 8530 O ASP B 485 -10.164-13.029-94.783 1.009.23 B

ATOM 8531 N ALAB 486 -11.296-11.132-95.148 1.009.55 B ^

ATOM 8532 CA ALA B 486 -12.597-11.755-94.9041.0010.52 B

ATOM 8533 CB ALA B 486 -13.699-10.695-94.868 1.007.16 B

ATOM 8534 C ALA B 486 -12.872-12.739-96.0391.0013.80 B

ATOM 85350 ALA B 486 -13.576-13.735-95.8661.0014.93 B ATOM 8536 N GLY B 487 -12306-12.457-97.2071.0015.14 B ATOM 8537 CA GLY B 487 -12.538-43.319-987340 1.0017.58 B

ATOM 8538 C GLYB 487 -11.746-14.608-98.2971.0019.58 B

ATOM 8539 O GLYB 487 -11.950-15.494-99.1371.0020.88 B

ATOM 8540 N ALAB48S -10.846447732T -97.3271.0019.58 B ATOM 8541 CA ALA B 488 -10.034-15.941 -97.213 1.0O 18.55 B

ATOM 8542 CB ALA B 438 -8.719-15.627-96.5321.00-17.44 B

ATOM 8543 C ALAB-488 -10.742-17.040-96.4461DΘ 18.27 B

ATOM 8544 O ALAB 488 -10.164-18.074-96.161 1.0017.35 B

ATOM 8545 N LYS B 489 -12,008-16.810-96.114 1.0018.98 B ATOM 8546 CA LYS-B 489 -1-2.790 -17.797 -95.3771.0021.06 B

ATOM 8547 CB LYS B 489 -13.463-17.154-94.1621.00.23.93 B

ATOM 8548 CG LYS B 489 -M511 -18.032 -93.4971.0024.84 B ATOM 8549 CD LYS B 489 -13.899-18.895-92.4041.0026.72 B

ATOM 8550 CE LYS B 489 -14.828 -20.034 -92.015 1.0028.79 B ATOM 8551 NZ LYS B 489 -14.104-21.331-91.9121.0028.31 B

ATOM 8552 C LYS B 489 -13.785 -18.449 -96.3321.0019.77 B

ATOM 8553 O LYS B 489 -14.552-17.763-97:0071.0021.32 B

ATOM 8554 N PHEB 490 ~13.768.-19.7-77 -96.3811:0017.26 B

ATOM 8555 CA PHE;&490 -14.578-20.517-97.343 1.0017.33- R ATOM 8556 CB PHE B49G- -14:799-21.947 -96τS461.0017.34 B

ATOM 8557 CG THE B 4-9X)- -15.639 -22.786 -97.767^" LOO 20rl 1 B ATOM 8558 CD! PHE B 430^" -15.054 -23.513 -98-.7901.0022.30 R ATOM 8559 CD2 PHE B 490 -17.014-22.847-97.6101.0020.26 B ATOM 8560 CEl PHE B 490 -15.824 -24.285 -99.6391.0024.55 B ATOM 8561 CE2PHEB490 -17.789-23.618-98.4561.0022.63 B

ATOM 8562 CZ PHE B 490 -17.193-24.338-99.4721.0023.62 B

ATOM 8563 C PHE B 490 -15.918-19.813-97.5191.0017.75 B

ATOM 85640 PHE B 490 -16.432-19.705-98.6321.0020.27 B

ATOM 8565 N HIS B 491 -16.478-19.336-96.413 1.0016.88 B ^

633

ATOM 8566 CA HIS B 491 -17.912 -19.093 -96.327 1.00 17.60 B

ATOM 8567 CB HIS B 491 -18.377 -19.127 -94.870 1.00 16.86 B

ATOM 8568 CG HIS B 491 -18.441 -20.505 -94.289 1.00 16.11 B

ATOM 8569 CD2 HIS B 491 -19.497 -21.271 -93.923 1.00 16.77 B ATOM 8570 NDl HIS B 491 -17315 -2O54 -94.024 1.00^"15L46 B

ATOM 8571 CEl HIS B 491 -17.673 -22.421 -93.519 1.00 15.98 B

ATOM 8572 NE2 HIS B 491 -18.992 -22.457 -93.447 1.00 17.51 B

ATOM 8573 C HIS B 491 -18.285 -17.760 -96.966 1.00 18.38 B

ATOM 8574 O HIS B 491 -19.454 -17.510 -97.261 1.00 1-8.58 B ATOM 8575 N VALB 492 -17.288 -16.907 -97.181 1.00 19.00 B

ATOM 8576 CA VAL B 492 -17.532 -15.614 -97.753 1.0020.70 B

ATOM 8577 CB VAL B 492 -16.435 -.14.639 -97.3m 1.00 21.13 B

ATOM 8578 CGl VAL B 492 -16.681 -13.324 -98.028 1.0020.70 B

ATOM 8579 CG2 VAL B 492 -16.428 -14.466 -95.847 1,0022.47 B ATOM 8-58O C VAL B 492 -17.647 -15.743 -99.249 1.0020.95 B^"

ATOM 8581 O VAL B 492 -18.685 -15.426 -99.804 1.00 22.68 B

ATOM 8582 N PRO B 493 -16.596 -16.229 -99.920 1.00 21.13 B

ATOM 8583 CD PRO B 493 -15.265 -16.629 -99.440 1.00 20.02 B

ATOM 8584 CA PRO B 493 -16.684 -16.367-101.372 1.0021.11 B ATOM 8585 CB PRO B 493 -15.262 -16.738-101.773 1.00 20.25 B

ATOM 8586 CG PRO B 493 -14.761 -17.459- 10Θ-.5&8 IJOO 2-lJM- B

ATOM 8587- C PRO B 493 -17.687 -17.414-101.805 1.0021:91 B

ATOM 8588 0 PRO B 493 -18.053 -17.464-102.965 1.00-24.26 B

ATOM 8589 N ASNB494 -T8T.128 -18.258-10&SS3 1:00:22.15 B ATΘM 8590- CA ASN B 494 -19.095 -19.286-101.228 -LOG 22:22 B

ATOM 8591 CB-ASN B 494 -18.682 -20.624^100.641 1.0022.65 B

ATOM S592^~CG ASN B 494 -17:608- -21.301-101.456 LOO 2532_ B

ATOM^" 8593 ODl ASN B 494 47.856 -22324-102.079 1.002731 B

ATOM 8594 ND2 ASN B 494 -16.409 -20.730-101.465 -1.002633 B ATOM 8595 C ASN B 494 -20.473 -18.904-100.750 1.00 22.52 B

ATOM 8596 O ASN B 494 -21368 -19.741-100.647 1.0022.26 B

ATOM 8597 N VAL B 495 -20.627 -17.627-100.441 LQO 23.05 B

ATOM 8598 CA VAL B 495 -21.900 -17.086 -99.992 1.00 25.08 B

ATOM 8599 CB VAL B 495 -22.759 -16.719-101.215 1.0024.66 B _m

ATOM 8600 CGl VAL B 495 -23.980-15.944-100.7921.0023.29 B

ATOM 8601 CG2VALB495 -21.930-15.918-102.2001.0025.51 B

ATOM 8602 C VAL B 495 -22.727-17.990-99.0721.0026.32 B

ATOM 8603 O VAL B 495 -23.862-18.315-99.3941.0026.71 B ATOM 8604 N THRB 496 -22.170-18.384-97.928 1.0028.25 B

ATOM 8605 CA THRB 496 -22.887-19.236-96.978 1.0028.40 B

ATOM 8606 CB THR B 496 -22.123-20.505-96.6961.0028.50 B

ATOM 8607 OGl THR B 496 -21.674-21.068-97.9301.0029.48 B

ATOM 8608 CG2THRB496 -23.016-21.492-95.9991.0028.41 B ATOM 8609 C THRB 496 -23.036-18.490-95.6681.0029.43 B

ATOM 8610 O THRB 496 -22.036-18.195-95.0021.002S.84 B

ATOM 8611 N PRO B 497 -24.284-18.169-95.2751.0030.66 B

ATOM 8612 CD PRO B 497 -25.574-18.526-95.8891.0030.26 B

ATOM 8613 CA PRO B 497 -24.500-17.443-94.0171.0031.28 B ATOM 8614 CB PRO B 497 -26.002-17.583-93.799 1.0030.95 B

ATOM 8615 CG PRO B 497 -26.530-17.573-95.188 1.0030.64 B

ATOM 8616 C PROB 497 -23.667-18.064-92.895 1.0031.52 B

ATOM 86170 PRO B 497 -23.309- -19.249 -92.973 1.00-31.04 B

ATOM 8618 N TYR B 498 -23350-17.275-91.865 1.0030.81 B ATOM 8619 CA TYRB 498 -22.527-17.782-90.768 LOO 30.31 B

ATOM 8620- CB TYR B 498 -21.194-17.024-90.7461.0028.88 B

ATOM 8621 CG TYRB-498 -20.003-17.831-90.2751.0026.33 B

ATOM 8622 CDl TYELB 498 -19385 -18.752 -91.110 LOO 2537 B

ATOM- 8623^" CEl TYRB 498 -18.275 -19.4.81 -90:684- 1.00^~25.46 B ATOM §624 CB2 TYRB 498 -19-4S5--17.660 -88.998 LOO 26.12 B

ATOM: 8625 CE2 TYRB-498 -18.379 -1&387 -88.565 LOO 26.34 B

ATOM 8626 CZ TYRB 498- -1777-84-19:289-89.4141.0025793 B

ATOM 8627 OH TYR B 498 -16.692-19.991-88.9921.0027.82 B-

ATOM 8628 C TYRB 498 -23.169-17-720-89.3761.0030.89 B ATOM 8629 O TYRB 498 -22.880-18.556-88.5221.0029.31 B

ATOM 8630 N ILE B 499 -24.037-16.736-89.1501.0032.64 B

ATOM 8631 CA ILE B 499 -24.681-16.583-87.851 1.0034.38 B

ATOM 8632 CB ILE B 499 -25.699-15.419-87.841 1.0034.77 B

ATOM 8633 CG2ILEB499 -26.915-15.772-88.6601.0035.18 B ATOM 8634 CGl ILE B 499 -26.126-15.125-86.404 1.0036.21 B

ATOM 8635 CDl ILE B 499 -24.953-14.837-85.465 1.0036.36 B

ATOM 8636 C DLE B 499 -25.386-17.859-87.4471.0035.56 B

ATOM 8637 O ILE B 499 -25.804 -18.018 -86.304 1.0037.84 B ATOM 8638^" N ARGB 500- -25.515-18.771-88.3981.0036.18 B

ATOM 8639 CA ARG B 500 -26.149-20.043-88.1361.0035.48 B

ATOM 8640 CB ARGB 500 -26.395-20.784-89.453 1.0036.53 B

ATOM 8641 CG ARG B 500 -25.159-20.957-90.318 1.0036.80 B

ATOM 8642 CD ARG B 500 -25.484-21.631-91.640 1.0036.18^" B ATOM 8643 NE ARG B 500 -26.457-20.872-92.4171.0034.83 B

ATOM 8644 CZ ARGB 500 -26.977-21.306-93.555 1.0034.17 B

ATOM 8645 NHiARGB 500 -26.598-22.491 -94.035 LOO 30:81 B

ATOM 8646 NH2 ARG B 500 -27.888-20.568-94.1891.0032.79 B

ATOM .8647 C ARGB 500 -25.238-20.849-87.2181.0035.01 B ATOM 86480 ARGB 500 -25.715-21.575-86.3641.0035.61 B

ATOM 8649 N TYRB 501 -23.923-20.715-87.383 1.0035.54 B

ATOM 8650 CA TYRB 501 -22.980-21.453-86.523 1.0036.53 B

ATOM 8651 CB TYRB 501 -21.571-21.482-87.083 1.0038.26 B

ATOM 8652 CG TYRB 501 -21.489-22.002-88.4691.0040.52 B ATOM 8653 CDl TYRB 501 -21.917-21.216-89.533 1.0041.17 B

ATOM 8654 CEl TYRB 501 -21.80ff--Zr.656 -90.831 1.0043.20 B

ATOM S655 CD2 TYRB 5θl -20.945-23.260-88,7301.0041.69 B

ATOM 8656 CE2 TYR B 501 -20.828-23.728-90.0291.00.43.82- B

ATOM 8657 CZ TYRB 501 -2-1.255 -22.914 -9L-081 1.00-44.78 B ATOM 8658- OH TYRB 501 -21.13-7 -23.346 -923S6 1.G0-45.46 B

ATOM 8659 C TYRB 50L -22:850 -20.912-85. T231.0035.80 B

ATOM a660 O TYRB 501 -22.379-21.610-84.220 LOO 35TlI Ε

ATOM 8661 N PHEB 502 -23.205 -19.655 -84.943 1.0β-34.30 B

ATOM 8662 CA PHE B 502 -23.119-19.115-83.6161.0034.55 B ATOM 8663 CB PHE B 502 -23.192-17.591-83,635 1.0035.53 B

ATOM 8664 CG PHE B 502 -23.232-16.974-82.271 1.0035.08 B

ATOM 8665 CDl PHE B 502 -22.127-17.012-81.4331.0034.96 B

ATOM 8666 CD2 PHE B 502 -24.382 -16.346 -81.8301.0035.17 B

ATOM 8667 CEl PHE B 502 -22.176-16.424-80.171 1.0035.89 B ATOM 8668 CE2PHEB502 -24.440-15.758-80.5761.0035.68 B

ATOM 8669 CZ PHE B 502 -23.338-15.796-79.745 1.0035.15 B

ATOM 8670 C PHE B 502 -24.323-19.716-82.921 1.0034.17 B

ATOM 8671 O PHE B 502 -24.181-20.440-81.9321.0034.41 B ATOM 8672 N VAL B 503 =25.505-19.449-83.466 LOO 32.84 B

ATOM 8673 CA VAL B 503 -26.728-19.992-82.894 1.0032.77 B

ATOM 8674 CB VAL B 503 -27.903-19.864-83.876 1.0029.99 B

ATOM 8675 CGl VAL B 503 -29.143-20.491-83.288 1.0028.76 B

ATOM 8676 CG2 VAL B 503 -28.156 -18.418^~-84.1861.0027.88 B ATOM 8677 C VAL B 503 -26.507-21.476-82.5671.0034.08 B

ATOM 8678. O VAL B 503 -26.826-21.956-81.475 1.6034.83 B

ATOM 8679 N SER B 504 -25.923 -22.18L-83.522 1.0034.68 B

ATOM 8680 CA SERB 504 -25.646-23.602-83.3861.0037.17 B

ATOM 8681 CB SERB 504 -24.906-24.105-84.628 1.0036.23 B ATOM 8682 OG SERB 504 -24343-25.389-84.405 1.0033.87 B

ATOM 86.83 C SERB 504 -24.856-24.013-82.1441.0039.30 B

ATOM 86840 SERB 504 -25.218-24.975-81.4641.0040.62 R

ATOM 8685 N PHE B 505 -23.764-23.311-81.8571.0040.55 B

ATOM 8686 CA PHE B 505 -22.-955-23.663-80.699 1.0040.15 B ATOM 8687 CB PHE B 505 -21.654-22.862-80.709 1.0038.56 B

ATOM 8688 CG PHE B 505 -20.565-23.492-81.535 1.0038.11 B

ATOM 8689 CDl PHE B 505 -2f)^"J46 -24.028. -82.7871Λ036.21 B

ATOM 8690 CD2 PHE B 505 -19.260-23.561-81.0541.0038.49 B

ATOM 8691 CTTJHE B 505 -1&851 -24.626 -83.546 1-.00- 36.39 B ATOM 8692 CE2 PHE B 505 -lJL253.r24.158 -81.809 UKL38.28- B

ATOM .8693 CZ PHE. B 505 -18.552 -24.693 -83.0591.0037.30 B

ATOM 8694 C PHE B 505 -23.709-23.461-79.388 1.0040.98 B

ATOM 8695 O PHE B 505 -23.594-24.267-78.4701.0041.79 B

ATOM 8696 N VAL B 506 -24.508-22.405-79.311 1.0040.62 B ATOM 8697 CA VAL B 506 -25.245-22.139-78.093 1.0040.01 B

ATOM 8698 CB VAL B 506 -25.813-20.718-78.101 1.0040.30 B

ATOM 8699 CGl VAL B 506 -26.728-20.506-76.9141.0040.71 B

ATOM 8700 CG2 VAL B 506 -24.667-19.724-78.051 1.0040.81 B

ATOM 8701 C VAL B 506 -26.366-23.131-77.888 1.0040.17 B ATOM 8702 O VAL B 506 -26.407-23.858-76.905 1.0042.32 B

ATOM 8703 N LEU B 507 -27.278-23.195-78.8301.0039.47 B

ATOM 8704 CA LEU B 507 -28.378-24,105-78.6441.0037.71 B

ATOM 8705 CB LEU B 507 -29.504- -23.664 -79.555 1.0038.39 B ATOM 8706 CG LEU B 507 -30.194-24.724-80.395 1.00-39.44 B

ATOM^" 8707 CDlLEU B 507 -31.423-24.045-80.8761.0039.93 B

ATOM 8708 CD2 LEU B 507 -29.333-25.277-81.554 1.0038.51 B

ATOM 8709 C LEUB 507 -28.050-25.592-78.813 1.0036.07 B

ATOM 8710 O LEU B.507 -28.932-26.451-78.7961.0034.52 B ATOM 8711 N GLN B 508 -26.778-25.911-78.9641.0034.86 B

ATOM 8712 CA GLN B 508 -26.446-27.311-79.121 1.0036.38 B

ATOM 8713 CB GLNB 508 -25.115-27.472-79.874 1.0036.65 B

ATOM 8714 CG GLN B 508 -23.886-27.852-79.088 1.0039.13 B

ATOM 8715 CD GLN B 508 -22.624-27.748.-79.949 1.0040.83 B ATOM 8716 OEl GLN B 508 -21.552-28.228-79.5721.0041.38 B

ATOM 8717 NE2 GLN B 508 -22.753 -27,106 -81.1Ϊ41.0041.16 B

ATOM 8718 C GLNB 508 -26.424-27.954-77.745 1.0037.07 B

ATOM 87190 GLNB 508 -26.661-29.158-77.598 1.0038.69 B

ATOM 8720 N PHE B 509 -26.192-27.131-76.725 1.0036.77 B ATOM 8721 CA PHE B 509 -26.162.-27.619-75.359 1.0034.04- B

ATOM 8722 CB PHE B 505 -25.252-26.744-74.510 1.0030.75 B

ATOM 8723 CG -PHE B 509 -23.829-26.813-74.929 1.0025:85 B

ATOM 8724- CDl PHE B 509 -23.348 -25.963 -75.895 1.0023.99 B

ATOM- 8725 CD2 -PHE B-5.09 -22.983 -27.779.-74.4121.00-25.746 B ATOM^" 8126 CEl PHE B 509 -22.042 -26.068 -76.348 1.0022.95 B

ATOM 8727 CE2 PHE-B 509 -2L-668 -27.895 -74.861 1:80-24.05 B

ATOM 8728 CZ -PHE-β-^:509 -21.200-27.037-75.8291.09-23.21 B

ATOM 8729 C PHE B 509 -27.569 ^27.664 -74.8041.0034.36 B

ATOM 8730 O PHEB 509 -27.831-28.387-73.843 1.0036.17 B ATOM 8731 N GLNB 510 -28.475-26.897-75.4071.0033.09 B

ATOM 8732 CA GLNB 510 -29.863-26.927-74.973 1.0034.00 B

ATOM 8733 CB GLNB 510 -30.693-25.871-75.6701.0031.42 B

ATOM 8734 CG GLNB 510 -30.167-24.503-75.5981.0031.27 B

ATOM 8735 CD GLNB 510 -31.304-23.545-75.4841.0033.32 B ATOM 8736 OEl GLNB 510 -31.204-22.375-75.8301.0035.98 B

ATOM 8737 NE2 GLNB 510 -32.412-24.039-74.9791.0034.88 B

ATOM 8738 C GLN B 510 -30.390-28.293-75.4021.0035.75 B

ATOM 87390 GLNB 510 -31.200-28.917-74.716 L0037.ll B ATOM- 8740- N PHE-B 511 -29.925-28.738-76,563 1.0036.99 B

ATOM 8741 CAPHETB-511 -30.320-30.025-77.101 1.0037.94 B

ATOM 8742 CB PHEB 511 -29.794-30.217-78.535 1.0037.98 B

ATOM 8743 CG PHEB 511 -30.614-29.521-79.6001.0036.83 B

ATOM 8744 CDl PHE B 511 -31.736-28.761-79.2701.0036.12 B ATOM 8745 CD2 PHE B 511 -30.250-29.627-80.943 1.0035.83 B

ATOM 8746 CEl PHE B 511 -32.484-28.115-80.263 1.0036.82 B

ATOM 8747 CE2 PHE B 511 -30.987 -28.989 -81.938 1.0035.10 B

ATOM 8748 CZ PHEB 511 -32.107-28.229-81.6001.0035.97 B

ATOM 8749 C EHEB 511 -29.705-31.078-76.2161.0037.98 B ATOM 8750 O PHE B ^'511 -30389-31.964-75.7121.0039.18 B

ATOM 8751 N HIS B 512 -28.400-30.974-76.0261.0037.92 B

ATOM 8752 CA HIS B 512 -27.692-31.939-75.2081.0039.42 B

ATOM 8753 CB HIS B 512 -26.246 -3.1.518 -75.044 LOO 36.90 B

ATOM 8754 CG HIS B 512 -25.379-32.598-74.5041.0035.63 B ATOM 8755 CD2 HIS B 512 -24.295-32.557-73.6951.0037.17 B

ATOM 8756 NDlHIS-B 512 -25.548-33.916-74.8541.0036.47 B

ATOM 8757 CETHISB 512 -24,601-34.644-74.2891.0038.46 B-

ATOM 8738--NE2HISB5-12 -23.827.-33.843-73.5801.0037.92 B

ATOM 8759 C "HIS B 512 -28.321- -32.145 -73:83-1 1.0041.51 B- ATOM 876O O- HIS B 512 -287516 -33.281 -73.3831.0042.72 B

ATOM 8161 Η ALAB 513 -28.642 -3-1.054^"-73.1521.0042.63- B

ATOM S762 CA ALA B 513 -29.241 -31.181-71.83S 1.0043.51 -B

ATOM 8763 CB ALA B 513 -29.385-29.804-71.1781.0044.18 B

ATOM 8764 C ALA B 513 -30,597-31.840-72.0071.0043.52 B ATOM 8765 O ALAB 513 -3t).876 -32.876 -71.395 1.0045.20 B

ATOM 8766 N ALAB 514 -31.433-31.249-72.8501.0041.91 B

ATOM 8767 CA ALAB 514 -32.767-31.786-73.0891.0041.55 B

ATOM 8768 CB ALAB 514 -33.462-30.990-74.195 1.0041.31 B

ATOM 8769 C ALAB 514 -32.751-33.279-73.438 1.0041.01 B ATOM 8770 O ALAB 514 -33.694-34.006-73.1371.0040.38 B

ATOM 8771 N ALAB 515 -31.671-33.738-74.0541.0040.77 B

ATOM 8772 CA ALA B 515 -31.577-35.134-74.422 1.0042.19 B

ATOM 8773 CB ALAB 515 -30.768-35.287-75.714 1.0041.95 B ATOM 8774 C ALA B 515 -30.976-35.986-73.314 1.004338 B

ATOM 8775 O ALAB 515 -31.348. -37.149 -73.156 LOO 43T80 B

ATOM 8776 N CYS B 516 -30.046-35.413-72.5501.0044.40 B

ATOM 8777 CA CYS B 516 -29.407-36.144-71.448 1.0045.80 B

ATOM 8778 C CYS B 516 -30.483 -36.451 -7θ.397^~170O 46.67 B ATOM 8779 O CYS B 516 -30.535 -37.533 -69:8121.00^" 45.90 B

ATOM 8780 CB CYS B 516 -28.232-35.322 -70.875 1.0045.53 B-

ATOM 8781 SG CYSJB 5 W -26.86.7 -35.354 -72.0411.0045.65 B

ATOM 8782 N LYS B 517 -31.383-35.488-70.2641.0047.45 B

ATOM 8783 CA LYS B 517 -32.519-35.517-69.361 1.0049.14 B ATOM 8784 CB LYS B 517 -33.241 -34.177 -69.448 l^~.0G-47.92 B

ATOM 8785 CG LYS B 517 -34.090-33.852-68.2771.0047.15 B

ATOM 8786 CD LYS B 517 -35.321 -33.085 -68.693 1.0047.11 B

ATOM 8787 CE LYS B 517 -36.167-32.780-67.461 1.0046.92 B

ATOM 8788 NZ LYS B 517 -37.538-32.315-67.825 1.0045.46 B ATOM 8789 C LYS B 517 -33.522-36.602-69.739 1.0050.95 B

ATOM 8790 O- LYS B 517 -33.89.8-37.446-68.9311.00-51.48 B

ATOM 8791 N GLUB 518 -34.005 -36.541 -7Θ.9771.0052.94 B

ATOM .8792. CA GLU-B 5-1-8 -34.995--37.540 -71.420- 1.0054.79. B

ATOM -8-793 CB^" GLU B 518 -35,771 -3:7:105 -72.678^" 1.0055.05 B -ATOM 8794 CG GLUB 518 -37:064 -36.3-13 -72.359" 1.00"5-5-.6L B

ATOM S795 CD GLUB 518 -38.377-37.021-72.7441.0056.76- -B

ATOM 8796 OE1-GL-UB5L8 -38.324-38.132_^73.319 l.Oσ 56.98 B

ATOM 8797 OE2 GLUB 518 -39.468-36.455-72.471 1.0056.64 B

ATOM 8798 C GLUB 518 -34.307-38.863-71.6491.0055.77 B ATOM 87990 GLUB 518 -34.952-39:908-71.775 1.0055.66 B

ATOM 8800 N ALAB 519 -32.980-38.825-71.705 1.0057.27 B

ATOM 8801 CA ALAB 519 -32.171-40.028-71.5491.0059.08 B

ATOM 8802 CB ALAB 519 -30.728-39.752-71.941 1.0059.49 B

ATOM 8803 C ALAB 519 -32.245-40.562-70.1221.0060.32 B ATOM 8804 O ALAB 519 -31.555-41.519-69.771 LOO 60.31 B ATOM 8805 N GLY B 520 -33.085 -39.936 -69.305 1.0061.29 B ATOM 8806 CA GLY B 520 -33.061

Claims

I . A crystal of the N-ciomain of ACE protein.

2. A crystal according to claim 1 wherein the N-domain of ACE protein is minimally glycosylated.

3. A crystal according to claim 2 wherein the N-domain of ACE protein is minimally glycosylated at amino acids 25, 45, 117, 289 and 480 of SEQ ID NO: 1.

4. A crystal according to any one of the preceding claims comprising atoms arranged in a spatial relationship represented by at least a portion of the structural coordinates set forth in Table A or Table B.

5. A crystal according to any one of the preceding claims wherein the crystal belongs to the space group C222_\.

7. A crystal according to any one _of the preceding claims having unit cell dimensions of: a=101.12 A, b=211.32 A, c=171.27 A.

8. A crystal according to any one of the preceding claims-wherein the crystal is a crystal of the N-domain of human ACE protein.

9. A crystal according to~any one of the preceding claims wherein the crystal further comprises a ligand^"bound to the N-domain of AG-E protein or_a portion thereof.

10. A crystal according to claim 9 wherein the ligand modulates the activity of N- domain of ACE protein.

I I. A crystal according to claim 10 wherein the ligand is an inhibitor of the N- domain of ACE protein.

12. A crystal according to claim 11 wherein the inhibitor is lisinopril or a derivative thereof.

13. A crystal according to claim 12 comprising atoms arranged in a spatial relationship represented by at least a portion of the structural co-ordinates set forth in

Table B.

14. A crystal according to claim 13 having^~unit cell dimensions of: a=101.32 A, b=211.90 A, c=171.03 A.

157 A method of preparing a crystal of the_N-domain of ACE protein comprising the steps of:

(a) culturing host cells comprising, the N-domain of ACE protein; (b) purifying the N-domain of ACE protein; and (c) crystallising the N-domain of ACE protein.

16. A method according to claim 15 wherein the N-domain of ACE protein is crystallised using about 5 mM HEPES and about 0.1 mM PMSF with an equal volume of a reservoir solution containing about 0.2M lithium sulphate, 15 % PEG -4000, about 100 mM CH₃€OONa.3H₂O pH 4.9 and about 10 μM ZnSO₄.7H₂O.

17. A method according to any of- claims 15 or 16 wherein the crystal that is prepared has a structure, defined by at least a portion of the structural co-ordinates set forth inJTable A.

18. A method according to any of claims 15 to 17 wherein the crystal belongs to the space group C222_\.

19. A method according to any of claims 15 to 18 wherein the crystal has the unit cell dimensions: a= 101.12 A, b=211.32 A and c-171.27 A.

20. A method according to any of claims 15 to 19 wherein the N-domain of ACE protein is an N-domain of human ACE protein.

21. A method according to any of claims 15 to 20 wherein the N-domain of ACE protein is crystallised in the presence of a ligand.

_5 22. A method according to claim- 21 wherein the ligand is a modulator of the N- domain of ACE protein.

23-. A method- according to claim 22 wherein the Iigand-is an inhibitor of the N- domain of ACE protein. 0

24. A method according to claim 23 wherein the inhibitor of the N-domain of ACE protein is lisinopril or a derivative thereof.

25. A method according to claim 24 wherein the crystal that is prepared has a 5 strasture defined by at least a portion of the structural co-ordinates set forth in Table B.

26. A method according to claim 25 wherein the crystal has unit cell dimensions: a- 101.32 A, b=211.90 A and c=17I.O3 A.

0 27. A method according to claim 25 wherein the crystal is crystallised using about 5 mM HEPES and" about OTl mM PMSF with an equal volume of a reservoir solution containing about 0.2M lithium sulphate, 18- % PEG 4000, about 100- mM -CH₃CΘONa.3H₂O pH-4.9 and about 10 μM ZnSO₄JH₂O.

5 ^~28. A method- of screening for a modulator of the N-domain of ACE protein wherein the method-comprises the use of a crystal according to any of claims 1-14.

29. A method according to claim 28 comprising the- steps of:

0 (a) providing at least a portion of the structural co-ordinates set forth in Table A or Table B; (b) employing at least a portion of the structural co-ordinates set forth in Table A or Table B to design or select or synthesise a putative modulator of the N-domain;

(c) contacting the putative modulator of the N-domain with the N-domain or a mutant, variant, homologue, derivative or fragment thereof in the presence of a substrate; and

(d) screening the-putative modulator of the N-domain in an assay for the potential to modulate the N-domaiπ.

30. A method of screening for a modulator of the C-domain of ACE protein wherein the method comprises the use of a crystal according to any of claims 1-14.

31. A method according to claim 30 comprising the steps of:

(a) providing at least a portion of the structural- co-ordinates set forth in Table A or Table B;

(b) employing at least a portion of the structural co-ordinates set forth in Table A or - Table B to design or select or synthesise a putative modulator of the C-domain of

ACE protein;

(c) contacting the putative-modulator of the^C-domain with the C-domain or a mutant, variant, homolόgue, derivative or ^fragment thereof in the-presence of- a substrate; and-

(d) screening the. putative modulator of the C-domain in an assay for the potential to selectively modulate the C-domain.

32. A method according to any one of claims 29 or 31 wherein at least a portion of the structural co-ordinates set forth in Table A or Table B and/or the putative modulator of the N-domain of ACE protein or C-domain of ACE protein and/or the substrate are provided on a machine-readable data storage medium comprising a data storage material encoded with machine readable data.

33. A method according to claim. 29, claim 31 or claim 32 wherein the putative N- domain modulator or the putative C-domain modulator is selected- from a library of compounds.

34. A method-according claim 29, claim" 31 or claim 32 wherein the putative N- domain modulator or C-domain modulator is selected ^"from a database.

33. A method_according- to any one of claims claim 28 to 31 whereitrthe putative^'N- domain modulator or C-domain modulator is designed de novo.

36. A method according to claim 29, claim 31 or claim 32 wherein the putative N- domain modulator or C-domain modulator is designed from a known ACE modulator.

37. A method according to claim 29, claim 31 or claim 32 wherein the design or selection of the putative N-domain modulator or C-domain modulator is performed in conjunction with computer modelling.

38. A method according to any of claims 28- to 37 wherein the selected N-domain modulator or C-domainjmodulator is useful ήrthe prevention, and/or treatment- of an ACE protein related disorder.

3-9. A method according to claim 38^" wherein the disorder is hypertension, myocardial infarction or congestive heart failure.

40. A process comprising the steps of:

(a) performing the method according to any of claims 28 to 38;

(b) identifying one or more modulators of the N-domain and/or C-domain; and (c) preparing a quantity of those one or more N-domain and/or C-domain modulators.

41. A process comprising the steps of:

(a) performing the method according to any of claims 28 to 38;

(b) identifying one or more N-domain and/or- C-domain modulators; and

(c) preparing a pharmaceutical-composition comprising those one or more identified N-domain modulators.

42. A process comprising the steps of:

(a) performing the method according to any of claims 28 to 38 ;

(b) identifying one or more N-domain and/or C-domain modulators;

(c). modifying those one or more N-domain and/or C-domain modulators; and

(d) optionally preparing a pharmaceutical composition comprising those one or more N-domain and/or C-domaϊn modulators.

43. A method of obtaining structural inforsiation about a molecule or a molecular complex of unknown structure by-using atrleasta portion of therstructural co-ordinates- set forth in N-jdomain of ACE protein, comprising the steps of:

(a) generating X-ray diffraction data from a crystallised molecule or molecular complex;

(b) applying at least a portion of the structure co-ordinates of the N-domain to said X- ray diffraction pattern to generate a three dimensional electron density map of at least a portion of the molecule or molecular complex; and (c) using all or a portion of the structural co-ordinates set forth in N-domain to generate homology models of the N-domain of ACE protein.

44. A method according to claim 43 wherein the structure co-ordinates of the N- 5 domain of ACE protein are used for domain co-operativity studies.

45. The N-domain of ACE protein modulator and/or the C-domain of ACE protein modulator identified by the method of any of claims 28 to 38.

10 46. The N-domain of ACE protein modulator according_^ to claim 45 wherein the modulator inhibits .the N-domain-of the ACE protein.

47. The C-domain of ACE protein-modulator according to claim 45 wherein the modulator inhibits the C-domain of ACE protein.

15

48. A pharmaceutical composition COmprising the N-domain of ACE protein modulator and/or the C-domain of ACE protein modulator according to any one of claims 45 to 47 and a pharmaceutically acceptable carrier, diluent, exciplent or adjuvant or any combination thereof.

-20

49. A method of preventing and/or treating an ACE related disorder comprising administering a modulator of the N-domain and/oτ C-domain according to any of claims 45 to- 47 and/or a pharmaceutical composition according- to claim 48 wherein said modulator or said composition is capable of causing a beneficial, preventative

25 and/or therapeutic effect.

50. A computer for producing a three-dimensional -representation of N-domain of ACE protein wherein said computer comprises:

30 (a) a computer-readable data storage medium comprising a data storage material encoded with computer-readable data, wherein said data comprises the structure co-ordinates of the N-domain; (b) a working memory for storing instructions for processing said computer- readable data;

(G) a central-processing unit coupled to said working memory and to said computer-readable data storage medium for processing said computer- machine readable data into said three-dimensional representation; and

(d) a display coupled to said central-processing unit for displaying said three- dimensional representation.

51. A machine-readable data storage medium comprising a data storage material encoded with machine readable data, wherein the data is defined by at least a portion of the structural co-ordinates of the N-domain of ACE protein set forth in Table A or Table B.

52. Use of the N-domain of ACE protein crystal in the preparation of a medicament to prevent and/or treat an ACE related disorder.

53_^ Use- according to claim 52 wherein the disorder is hypertension, myocardial infarction or congestive heart failure.

54. Use of at least a portion of the structural co-ordinates set forth in Table A or Table B to screen for -modulators of the N-domain of- ACE protein and/or the C- domain of the ACE protein.

55. Use of at least a portion of the structural co-ordinates set forth in Table A or Table B to solve the structure of the crystalline form of any other protein with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein.

56. Use of at least a portion of the structural co-ordinates set forth in Table A or Table B in molecular design techniques to design, select and synthesise modulators of the N-domain of ACE protein and/or the C-domain of ACE protein.

57. Use of at least a portion of the structural co-ordinates set forth in Table A or Table B in the development of compounds that can isomerise to reaction intermediates in the chemical reaction of a substrate or other compound that binds to

5 the N-domain of AXE protein and/or the C-domain of ACE protein.

58. Use of at least a portion of the structural co-ordinates set forth in Table A or Table B to screen small molecule databases- for chemical entities or compounds that modulate the N-domain of ACE protein or the C-domain of ACE protein. 0

"59. Use^" of at least a portion of the structural-co-ordinates set forth in Table A. or Table B to solve the structure of the crystalline form of any other domain with significant amino acid- sequence homology to any functional domain of the N-domain of ACE protein. 5

60. Use according to claim- 59 wherein the structure of the crystalline form of any other domain with significant amino acid sequence homology to any functional domain of the N-domain of ACE protein is solved using molecular replacement.

a 61. Use of at least- a portion of the structural co-ordinates set forth in Table A or Table B "to identify the binding site of any modulator of ths N-domain of ACE protein.

62. Use- according to claim -&l wherein the binding site is that of lisinopril or 5 derivatives thereof.