WO2007084321A3 - Antibodies to ox-2/cd200 and uses thereof - Google Patents

Antibodies to ox-2/cd200 and uses thereof Download PDF

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Publication number
WO2007084321A3
WO2007084321A3 PCT/US2007/000711 US2007000711W WO2007084321A3 WO 2007084321 A3 WO2007084321 A3 WO 2007084321A3 US 2007000711 W US2007000711 W US 2007000711W WO 2007084321 A3 WO2007084321 A3 WO 2007084321A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
depleting
modulating
compositions
application provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/000711
Other languages
French (fr)
Other versions
WO2007084321A2 (en
Inventor
Katherine S Bowdish
Anke Kretz-Rommel
Mcknight Susan Faas
Jeremy P Springhorn
Dayang Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexion Pharmaceuticals Inc
Original Assignee
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020087019334A priority Critical patent/KR101459159B1/en
Priority to BRPI0707126-4A priority patent/BRPI0707126A2/en
Priority to AU2007207764A priority patent/AU2007207764B2/en
Priority to EP16163753.3A priority patent/EP3101033B1/en
Priority to KR1020147016937A priority patent/KR20140091765A/en
Priority to JP2008550399A priority patent/JP5404052B2/en
Priority to RU2008133032/10A priority patent/RU2520088C2/en
Priority to MX2008009015A priority patent/MX2008009015A/en
Priority to CA2636577A priority patent/CA2636577C/en
Priority to US12/087,683 priority patent/US8075884B2/en
Priority to EP07716538A priority patent/EP1984403A2/en
Priority to NZ569903A priority patent/NZ569903A/en
Application filed by Alexion Pharmaceuticals Inc filed Critical Alexion Pharmaceuticals Inc
Publication of WO2007084321A2 publication Critical patent/WO2007084321A2/en
Publication of WO2007084321A3 publication Critical patent/WO2007084321A3/en
Priority to IL192668A priority patent/IL192668A/en
Anticipated expiration legal-status Critical
Priority to US13/311,910 priority patent/US8709415B2/en
Priority to US13/771,911 priority patent/US9000133B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)

Abstract

This application provides methods and compositions for modulating and/or depleting CD200 positive cells.
PCT/US2007/000711 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof Ceased WO2007084321A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
BRPI0707126-4A BRPI0707126A2 (en) 2006-01-12 2007-01-11 ox-2 / cd200 antibodies and use of these
AU2007207764A AU2007207764B2 (en) 2006-01-12 2007-01-11 Antibodies to OX-2/CD200 and uses thereof
EP16163753.3A EP3101033B1 (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof
KR1020147016937A KR20140091765A (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof
JP2008550399A JP5404052B2 (en) 2006-01-12 2007-01-11 Antibody to OX-2 / CD200 and use thereof
RU2008133032/10A RU2520088C2 (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and their application
MX2008009015A MX2008009015A (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof.
US12/087,683 US8075884B2 (en) 2006-01-12 2007-01-11 Antibodies to OX-2/CD200 and uses thereof
CA2636577A CA2636577C (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof
KR1020087019334A KR101459159B1 (en) 2006-01-12 2007-01-11 Antibodies to OX-2 / CD200 and their uses
NZ569903A NZ569903A (en) 2006-01-12 2007-01-11 Antibodies to OX-2/CD200 and uses thereof
EP07716538A EP1984403A2 (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof
IL192668A IL192668A (en) 2006-01-12 2008-07-07 Anti-cd200 antibodies for use in treating cancer and use of anti- cd200 antibodies in the preparation of medicaments for treating cancer
US13/311,910 US8709415B2 (en) 2006-01-12 2011-12-06 Antibodies to OX-2/CD200 and uses thereof
US13/771,911 US9000133B2 (en) 2006-01-12 2013-02-20 Antibodies to OX-2/CD200 and uses thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US75842606P 2006-01-12 2006-01-12
US75908506P 2006-01-12 2006-01-12
US60/759,085 2006-01-12
US60/758,426 2006-01-12
US80199106P 2006-05-18 2006-05-18
US60/801,991 2006-05-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/087,683 A-371-Of-International US8075884B2 (en) 2006-01-12 2007-01-11 Antibodies to OX-2/CD200 and uses thereof
US13/311,910 Division US8709415B2 (en) 2006-01-12 2011-12-06 Antibodies to OX-2/CD200 and uses thereof

Publications (2)

Publication Number Publication Date
WO2007084321A2 WO2007084321A2 (en) 2007-07-26
WO2007084321A3 true WO2007084321A3 (en) 2007-11-08

Family

ID=38068567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/000711 Ceased WO2007084321A2 (en) 2006-01-12 2007-01-11 Antibodies to ox-2/cd200 and uses thereof

Country Status (21)

Country Link
US (3) US8075884B2 (en)
EP (3) EP1984403A2 (en)
JP (3) JP5404052B2 (en)
KR (2) KR101459159B1 (en)
CN (1) CN103690947A (en)
AU (1) AU2007207764B2 (en)
BR (1) BRPI0707126A2 (en)
CA (1) CA2636577C (en)
DK (1) DK2463305T3 (en)
ES (2) ES2709672T3 (en)
HU (1) HUE028179T2 (en)
IL (1) IL192668A (en)
MX (1) MX2008009015A (en)
NZ (2) NZ569903A (en)
PL (1) PL2463305T3 (en)
PT (1) PT2463305T (en)
RU (2) RU2520088C2 (en)
SG (2) SG10201400422QA (en)
SI (1) SI2463305T1 (en)
TW (1) TW200804422A (en)
WO (1) WO2007084321A2 (en)

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