WO2007087570A3 - Polymerized hemoglobin media and its use in isolation and transplantation of islet cells - Google Patents

Polymerized hemoglobin media and its use in isolation and transplantation of islet cells Download PDF

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Publication number
WO2007087570A3
WO2007087570A3 PCT/US2007/060989 US2007060989W WO2007087570A3 WO 2007087570 A3 WO2007087570 A3 WO 2007087570A3 US 2007060989 W US2007060989 W US 2007060989W WO 2007087570 A3 WO2007087570 A3 WO 2007087570A3
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WIPO (PCT)
Prior art keywords
methods
suspensions
solutions
mammalian cells
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/060989
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French (fr)
Other versions
WO2007087570A2 (en
Inventor
Marc DOUBLEDAY
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Northfield Laboratories Inc
Original Assignee
Northfield Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northfield Laboratories Inc filed Critical Northfield Laboratories Inc
Priority to EP07762535A priority Critical patent/EP1978802A2/en
Priority to JP2008552556A priority patent/JP2009524436A/en
Publication of WO2007087570A2 publication Critical patent/WO2007087570A2/en
Publication of WO2007087570A3 publication Critical patent/WO2007087570A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of isolating mammalian cells, such as pancreatic islets, methods of preserving mammalian tissue and organs, methods of aiding the recovery of mammalian cells following their isolation, methods of maintaining mammalian cells, methods of propagating mammalian cells, and methods of treating a mammal with diabetes.
PCT/US2007/060989 2006-01-24 2007-01-24 Polymerized hemoglobin media and its use in isolation and transplantation of islet cells Ceased WO2007087570A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07762535A EP1978802A2 (en) 2006-01-24 2007-01-24 Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
JP2008552556A JP2009524436A (en) 2006-01-24 2007-01-24 Polymerized hemoglobin medium and its use in isolation and transplantation of islet cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76166306P 2006-01-24 2006-01-24
US60/761,663 2006-01-24

Publications (2)

Publication Number Publication Date
WO2007087570A2 WO2007087570A2 (en) 2007-08-02
WO2007087570A3 true WO2007087570A3 (en) 2007-12-06

Family

ID=38293339

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/060989 Ceased WO2007087570A2 (en) 2006-01-24 2007-01-24 Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
PCT/US2007/060987 Ceased WO2008021577A2 (en) 2006-01-24 2007-01-24 Polymerized hemoglobin media and its use in isolation and transplantation of islet cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/060987 Ceased WO2008021577A2 (en) 2006-01-24 2007-01-24 Polymerized hemoglobin media and its use in isolation and transplantation of islet cells

Country Status (4)

Country Link
US (6) US20070196810A1 (en)
EP (1) EP1978802A2 (en)
JP (1) JP2009524436A (en)
WO (2) WO2007087570A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP1978802A2 (en) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
FR2931164B1 (en) 2008-05-16 2010-08-20 Maco Pharma Sa METHOD FOR PRESERVING INSULIN SECRETORY CELLS FOR TRANSPLANTING
FR2959754B1 (en) 2010-05-05 2012-06-08 Maco Pharma Sa BIOLOGICAL MEDIUM FOR PRESERVING PREPARATION OF INSULIN SECRETORY CELLS.
US10433538B2 (en) 2012-10-12 2019-10-08 University of Pittsburgh—of the Commonwealth System of Higher Education Compositions and methods for organ preservation
WO2014124278A1 (en) * 2013-02-07 2014-08-14 OPK Biotech, LLC Perfusion of prospective donor hearts with polymerized hemoglobin
US20210352887A1 (en) * 2018-10-12 2021-11-18 VirTech Bio, Inc. Oxygenation media for ex-vivo preservation of organs and tissues

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US6506599B1 (en) * 1999-10-15 2003-01-14 Tai-Wook Yoon Method for culturing langerhans islets and islet autotransplantation islet regeneration

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Also Published As

Publication number Publication date
US20110142808A1 (en) 2011-06-16
JP2009524436A (en) 2009-07-02
US20170355961A1 (en) 2017-12-14
WO2007087570A2 (en) 2007-08-02
US20130316455A1 (en) 2013-11-28
US20070196810A1 (en) 2007-08-23
US9657271B2 (en) 2017-05-23
EP1978802A2 (en) 2008-10-15
US20130095467A1 (en) 2013-04-18
US20110200981A1 (en) 2011-08-18
WO2008021577A3 (en) 2008-10-02
WO2008021577A2 (en) 2008-02-21

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