WO2007100376A3 - Compositions and methods for dermal delivery of drugs - Google Patents

Compositions and methods for dermal delivery of drugs Download PDF

Info

Publication number
WO2007100376A3
WO2007100376A3 PCT/US2006/048059 US2006048059W WO2007100376A3 WO 2007100376 A3 WO2007100376 A3 WO 2007100376A3 US 2006048059 W US2006048059 W US 2006048059W WO 2007100376 A3 WO2007100376 A3 WO 2007100376A3
Authority
WO
WIPO (PCT)
Prior art keywords
volatile
formulation
methods
volatile solvent
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/048059
Other languages
French (fr)
Other versions
WO2007100376A2 (en
Inventor
Jie Zhang
Kevin S Warner
Sanjay Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zars Inc
Original Assignee
Zars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zars Inc filed Critical Zars Inc
Priority to CN200680052642XA priority Critical patent/CN101370453B/en
Priority to JP2008545866A priority patent/JP2009519956A/en
Priority to CA002633464A priority patent/CA2633464A1/en
Priority to AU2006339350A priority patent/AU2006339350A1/en
Priority to EP06849969A priority patent/EP1968541A2/en
Publication of WO2007100376A2 publication Critical patent/WO2007100376A2/en
Anticipated expiration legal-status Critical
Publication of WO2007100376A3 publication Critical patent/WO2007100376A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least one solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The formulation can be formulated to contain at least two volatile solvents, at least two non-volatile solvents, or at least two solidifying agents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
PCT/US2006/048059 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs Ceased WO2007100376A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN200680052642XA CN101370453B (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
JP2008545866A JP2009519956A (en) 2005-12-14 2006-12-14 Compositions and methods for skin delivery of drugs
CA002633464A CA2633464A1 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
AU2006339350A AU2006339350A1 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs
EP06849969A EP1968541A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75063705P 2005-12-14 2005-12-14
US75052105P 2005-12-14 2005-12-14
US60/750,637 2005-12-14
US60/750,521 2005-12-14

Publications (2)

Publication Number Publication Date
WO2007100376A2 WO2007100376A2 (en) 2007-09-07
WO2007100376A3 true WO2007100376A3 (en) 2008-09-25

Family

ID=38459470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048059 Ceased WO2007100376A2 (en) 2005-12-14 2006-12-14 Compositions and methods for dermal delivery of drugs

Country Status (5)

Country Link
EP (1) EP1968541A2 (en)
JP (1) JP2009519956A (en)
AU (1) AU2006339350A1 (en)
CA (1) CA2633464A1 (en)
WO (1) WO2007100376A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102176913B (en) * 2008-10-08 2014-08-13 高田制药株式会社 Tacrolimus preparation for external applications
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
DE102011085509A1 (en) * 2011-10-31 2013-05-02 Beiersdorf Ag Fixation of perfume on wet skin
GB2496656B (en) * 2011-11-18 2015-12-09 Lrc Products Film-Forming Formulation
RS59357B2 (en) * 2013-11-14 2022-11-30 Lipidor Ab DIFFERENT TOPICAL CARRIER AND SUBSTANCE CONTAINING PHOSPHATIDYLCHOLINE
WO2016121996A1 (en) * 2015-01-30 2016-08-04 株式会社メドレックス Aqueous preparation for external use
CN108282998B (en) 2015-06-18 2021-07-06 凡利亚药品北美公司 A topical composition comprising a corticosteroid and a retinoid for the treatment of psoriasis
US11311482B2 (en) 2017-05-12 2022-04-26 Bausch Health Us, Llc Topical compositions and methods for treating skin diseases
EP4017474A1 (en) * 2019-08-21 2022-06-29 Timber Pharmaceuticals, Inc. Solvent delivery system for topical delivery of active agents
CN116723865A (en) * 2021-01-29 2023-09-08 花王株式会社 External preparation composition
JP7811853B2 (en) 2021-01-29 2026-02-06 花王株式会社 External preparation composition
EP4578441A1 (en) 2023-12-29 2025-07-02 PlantTec Medical GmbH Treatment of localized pain
CN118743761A (en) * 2024-06-18 2024-10-08 华润紫竹药业有限公司 A solidification solubilization method for a progesterone self-emulsifying liquid preparation and a progesterone self-emulsifying solid preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives

Also Published As

Publication number Publication date
CA2633464A1 (en) 2007-09-07
WO2007100376A2 (en) 2007-09-07
JP2009519956A (en) 2009-05-21
EP1968541A2 (en) 2008-09-17
AU2006339350A1 (en) 2007-09-07

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