WO2007100412A3 - Methods and compositions related to the modulation of riboswitches - Google Patents

Methods and compositions related to the modulation of riboswitches Download PDF

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Publication number
WO2007100412A3
WO2007100412A3 PCT/US2006/062494 US2006062494W WO2007100412A3 WO 2007100412 A3 WO2007100412 A3 WO 2007100412A3 US 2006062494 W US2006062494 W US 2006062494W WO 2007100412 A3 WO2007100412 A3 WO 2007100412A3
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Prior art keywords
riboswitches
methods
modulation
compositions related
compositions
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Ceased
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PCT/US2006/062494
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French (fr)
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WO2007100412A2 (en
Inventor
Ronald R Breaker
Kenneth F Blount
Izabela J Puskarz
John K Wickiser
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Yale University
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Yale University
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Priority to EP06850351A priority Critical patent/EP1974052A2/en
Priority to US12/158,168 priority patent/US8313901B2/en
Priority to JP2008547774A priority patent/JP2009524411A/en
Publication of WO2007100412A2 publication Critical patent/WO2007100412A2/en
Publication of WO2007100412A3 publication Critical patent/WO2007100412A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Disclosed herein are methods and compositions related to the detection of conformational changes and interactions with trigger molecules in riboswitches.
PCT/US2006/062494 2005-12-21 2006-12-21 Methods and compositions related to the modulation of riboswitches Ceased WO2007100412A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06850351A EP1974052A2 (en) 2005-12-21 2006-12-21 Methods and compositions related to the modulation of riboswitches
US12/158,168 US8313901B2 (en) 2005-12-21 2006-12-21 Methods and compositions related to the modulation of riboswitches
JP2008547774A JP2009524411A (en) 2005-12-21 2006-12-21 Methods and compositions related to the regulation of riboswitches

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75272605P 2005-12-21 2005-12-21
US60/752,726 2005-12-21

Publications (2)

Publication Number Publication Date
WO2007100412A2 WO2007100412A2 (en) 2007-09-07
WO2007100412A3 true WO2007100412A3 (en) 2008-04-17

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PCT/US2006/062494 Ceased WO2007100412A2 (en) 2005-12-21 2006-12-21 Methods and compositions related to the modulation of riboswitches

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US (1) US8313901B2 (en)
EP (1) EP1974052A2 (en)
JP (1) JP2009524411A (en)
WO (1) WO2007100412A2 (en)

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US20110237549A1 (en) * 2008-03-27 2011-09-29 Memorial Sloan Kettering Cancer Center Modulators of rna riboswitches
WO2010141085A1 (en) * 2009-06-02 2010-12-09 Biorelix Pharmaceuticals, Inc. Methods for screening and identifying compounds
WO2011094027A1 (en) 2010-02-01 2011-08-04 Hlavka Edwin J Bacteriotherapy for clostridium difficile colitis
EP2531223A4 (en) * 2010-02-04 2013-06-26 Biorelix Inc Novel methods and utilities
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511099B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
EP4234011A3 (en) 2013-06-05 2023-09-20 Rebiotix, Inc. Microbiota restoration therapy (mrt), compositions and methods of manufacture
US10383901B2 (en) 2013-06-05 2019-08-20 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9694039B2 (en) 2013-06-05 2017-07-04 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9782445B2 (en) 2013-06-05 2017-10-10 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
WO2015044456A1 (en) * 2013-09-30 2015-04-02 Danmarks Tekniske Universitet Improved biosensor-based detection system
US10905726B2 (en) 2015-06-09 2021-02-02 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
CN107921072A (en) 2015-06-09 2018-04-17 雷柏奥提斯有限公司 Micropopulation resumes treatment（MRT）Composition and manufacture method
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10799539B2 (en) 2015-06-09 2020-10-13 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
WO2018034843A1 (en) * 2016-08-17 2018-02-22 Maumita Mandal Materials and methods for controlling gene expression
CN106635940B (en) * 2016-10-19 2019-10-18 齐鲁工业大学 Construction method and application of a glucosamine-producing Bacillus subtilis
WO2018187687A1 (en) * 2017-04-07 2018-10-11 Arizona Board Regents On Behalf Of Arizona State University Integrated diagnostic devices having embedded biomolecular computing systems and uses thereof
US11155821B2 (en) 2018-07-31 2021-10-26 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for tagging ribonucleic acids
WO2021195218A1 (en) 2020-03-24 2021-09-30 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing gaucher therapeutics
AU2021244555A1 (en) 2020-03-24 2022-11-24 Generation Bio Co. Non-viral dna vectors and uses thereof for expressing factor ix therapeutics
US20260055426A1 (en) 2022-08-19 2026-02-26 Generation Bio Co. CLEAVABLE CLOSED-ENDED DNA (ceDNA) AND METHODS OF USE THEREOF
WO2026085495A1 (en) 2024-10-18 2026-04-23 Generation Bio Co. Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor

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