WO2007101163A3 - System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system - Google Patents

System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system Download PDF

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Publication number
WO2007101163A3
WO2007101163A3 PCT/US2007/062822 US2007062822W WO2007101163A3 WO 2007101163 A3 WO2007101163 A3 WO 2007101163A3 US 2007062822 W US2007062822 W US 2007062822W WO 2007101163 A3 WO2007101163 A3 WO 2007101163A3
Authority
WO
WIPO (PCT)
Prior art keywords
spectral
fiber array
unmixing
spectra
spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/062822
Other languages
French (fr)
Other versions
WO2007101163A2 (en
Inventor
Jason H Neiss
Patrick J Treado
Robert Schweitzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChemImage Corp
Original Assignee
ChemImage Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ChemImage Corp filed Critical ChemImage Corp
Priority to EP07757497A priority Critical patent/EP1999440A2/en
Publication of WO2007101163A2 publication Critical patent/WO2007101163A2/en
Publication of WO2007101163A3 publication Critical patent/WO2007101163A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G01J3/0221—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers the fibers defining an entry slit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/024—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using means for illuminating a slit efficiently (e.g. entrance slit of a spectrometer or entrance face of fiber)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0294—Multi-channel spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/04—Slit arrangements slit adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/0833—Fibre array at detector, resolving
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods
    • G01N2201/1293—Using chemometrical methods resolving multicomponent spectra

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based ('FAST') spectroscopic system for performing spectral unmixing of a mixture containing multiple polymorphs. In an embodiment, a first spectrum of a mixture containing polymorphs of a compound is obtained using a photon detector and a fiber array spectral translator having plural fibers. A set of second spectra is provided where each spectrum of the set of second spectra may be representative of a different polymorph of the compound. The first spectrum and the set of second spectra may be compared, and based on the comparison, the presence of one or more polymorphs in the mixture may be determined.
PCT/US2007/062822 2006-02-27 2007-02-26 System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system Ceased WO2007101163A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07757497A EP1999440A2 (en) 2006-02-27 2007-02-26 System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77721906P 2006-02-27 2006-02-27
US60/777,219 2006-02-27

Publications (2)

Publication Number Publication Date
WO2007101163A2 WO2007101163A2 (en) 2007-09-07
WO2007101163A3 true WO2007101163A3 (en) 2008-04-24

Family

ID=38459779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/062822 Ceased WO2007101163A2 (en) 2006-02-27 2007-02-26 System and method for spectral unmixing in a fiber array spectral translator based polymorph screening system

Country Status (3)

Country Link
US (1) US7471386B2 (en)
EP (1) EP1999440A2 (en)
WO (1) WO2007101163A2 (en)

Families Citing this family (8)

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US8098373B2 (en) * 2009-04-15 2012-01-17 Chemimage Corporation Spatially and spectrally parallelized fiber array spectral translator system and method of use
JP5671766B2 (en) * 2009-10-01 2015-02-18 トルネード スペクトラル システムズ，インコーポレイテッド Optical slicer to improve the spectral resolution of dispersive spectrometers
US8502977B1 (en) * 2010-06-01 2013-08-06 Kla-Tencor Corporation Angular resolved spectroscopic scatterometer
CN102865924B (en) * 2012-08-21 2014-11-12 中国科学院安徽光学精密机械研究所 Slit assembly for adjusting and testing hyperspectral imaging spectrometer
RU2692121C2 (en) * 2013-03-05 2019-06-21 Общество с ограниченной ответственностью "Центр исследований и разработок концерна Агат" Method of lidar probing and device for its implementation
WO2016115631A1 (en) 2015-01-21 2016-07-28 Tornado Spectral Systems Inc. Hybrid image-pupil optical reformatter
EP3345119A4 (en) * 2016-01-29 2019-04-24 Hewlett-Packard Development Company, L.P. Optical readers
US10802230B2 (en) * 2017-08-30 2020-10-13 Duke University Fiber-based multi-source photon collector and systems and methods utilizing same

Citations (1)

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US20040218172A1 (en) * 2003-01-24 2004-11-04 Deverse Richard A. Application of spatial light modulators for new modalities in spectrometry and imaging

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DE9414467U1 (en) 1994-07-15 1994-11-10 Bruker Analytische Meßtechnik GmbH, 76287 Rheinstetten Raman spectrometer with a measuring probe
US5615673A (en) 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
US6100975A (en) 1996-05-13 2000-08-08 Process Instruments, Inc. Raman spectroscopy apparatus and method using external cavity laser for continuous chemical analysis of sample streams
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Also Published As

Publication number Publication date
US20070201022A1 (en) 2007-08-30
EP1999440A2 (en) 2008-12-10
US7471386B2 (en) 2008-12-30
WO2007101163A2 (en) 2007-09-07

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