WO2007102861A3 - Modulators of cdc2-like kinases (clks) and methods of use thereof - Google Patents

Modulators of cdc2-like kinases (clks) and methods of use thereof Download PDF

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Publication number
WO2007102861A3
WO2007102861A3 PCT/US2006/046058 US2006046058W WO2007102861A3 WO 2007102861 A3 WO2007102861 A3 WO 2007102861A3 US 2006046058 W US2006046058 W US 2006046058W WO 2007102861 A3 WO2007102861 A3 WO 2007102861A3
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WIPO (PCT)
Prior art keywords
disorders
diseases
cdc2
modulators
methods
Prior art date
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Ceased
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PCT/US2006/046058
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French (fr)
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WO2007102861A2 (en
Inventor
Jill Milne
Karl D Normington
Pere Puigserver
Joseph Rodgers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Sirtris Pharmaceuticals Inc
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Johns Hopkins University
Sirtris Pharmaceuticals Inc
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Priority to JP2008543502A priority Critical patent/JP2009521408A/en
Priority to EP06849912A priority patent/EP1957109A2/en
Priority to AU2006339607A priority patent/AU2006339607A1/en
Priority to CA002631713A priority patent/CA2631713A1/en
Publication of WO2007102861A2 publication Critical patent/WO2007102861A2/en
Anticipated expiration legal-status Critical
Publication of WO2007102861A3 publication Critical patent/WO2007102861A3/en
Ceased legal-status Critical Current

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Abstract

Provided herein are methods for using Cdc2-like kinase (Clk) modulators for treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, ocular disorders, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a Clk modulating compound in combination with another therapeutic agent.
PCT/US2006/046058 2005-12-02 2006-12-01 Modulators of cdc2-like kinases (clks) and methods of use thereof Ceased WO2007102861A2 (en)

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JP2008543502A JP2009521408A (en) 2005-12-02 2006-12-01 Modulator of Cdc2-like kinase (CLK) and method of use thereof
EP06849912A EP1957109A2 (en) 2005-12-02 2006-12-01 Modulators of cdc2-like kinases (clks) and methods of use thereof
AU2006339607A AU2006339607A1 (en) 2005-12-02 2006-12-01 Modulators of Cdc2-like kinases (Clks) and methods of use thereof
CA002631713A CA2631713A1 (en) 2005-12-02 2006-12-01 Modulators of cdc2-like kinases (clks) and methods of use thereof

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