WO2007106284A3 - Silicone based emulsions for topical drug delivery - Google Patents

Silicone based emulsions for topical drug delivery Download PDF

Info

Publication number
WO2007106284A3
WO2007106284A3 PCT/US2007/004011 US2007004011W WO2007106284A3 WO 2007106284 A3 WO2007106284 A3 WO 2007106284A3 US 2007004011 W US2007004011 W US 2007004011W WO 2007106284 A3 WO2007106284 A3 WO 2007106284A3
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion
dispersed
dissolved
drug delivery
silicone based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/004011
Other languages
French (fr)
Other versions
WO2007106284A2 (en
Inventor
Gareth Winckle
David W Osborne
Gordon J Dow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Pharmaceutical Sciences Inc
Original Assignee
Dow Pharmaceutical Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Pharmaceutical Sciences Inc filed Critical Dow Pharmaceutical Sciences Inc
Priority to EP07750823A priority Critical patent/EP1996170A2/en
Publication of WO2007106284A2 publication Critical patent/WO2007106284A2/en
Publication of WO2007106284A3 publication Critical patent/WO2007106284A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)

Abstract

A water-in-oil emulsion is provided in which the lipophilic phase of the emulsion contains a silicone fluid and an emulsifier, a hydrophilic phase, and a pharmaceutically active compound. The active pharmaceutical ingredient is dissolved or dispersed in the emulsion and is partitioned in the emulsion so that all or a portion of the amount of the chemical compound dissolved or dispersed in the emulsion is dissolved or dispersed in the aqueous phase of the emulsion. The emulsion of the invention provides increased penetration into skin of the chemical compound dissolved or dispersed in the aqueous phase.
PCT/US2007/004011 2006-03-03 2007-02-15 Silicone based emulsions for topical drug delivery Ceased WO2007106284A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07750823A EP1996170A2 (en) 2006-03-03 2007-02-15 Silicone based emulsions for topical drug delivery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77882506P 2006-03-03 2006-03-03
US60/778,825 2006-03-03
US11/699,906 2007-01-30
US11/699,906 US20070207107A1 (en) 2006-03-03 2007-01-30 Silicone based emulsions for topical drug delivery

Publications (2)

Publication Number Publication Date
WO2007106284A2 WO2007106284A2 (en) 2007-09-20
WO2007106284A3 true WO2007106284A3 (en) 2008-06-26

Family

ID=38471683

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/004011 Ceased WO2007106284A2 (en) 2006-03-03 2007-02-15 Silicone based emulsions for topical drug delivery

Country Status (3)

Country Link
US (1) US20070207107A1 (en)
EP (1) EP1996170A2 (en)
WO (1) WO2007106284A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
DE102010006612A1 (en) 2010-02-01 2011-08-04 Beiersdorf AG, 20253 Stabilized preparations based on water in silicone or silicone in water emulsion comprising butylene glycols
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
EP2841106A1 (en) * 2012-04-27 2015-03-04 Dow Corning Corporation Topical formulation compositions containing silicone based excipients to deliver actives to a substrate
US20140335172A1 (en) * 2013-05-10 2014-11-13 The University Of Hong Kong Ophthalmological rinsing agent and methods therefof
AU2014329421B2 (en) 2013-10-03 2018-08-02 Dow Pharmaceutical Sciences, Inc. Stabilized efinaconazole compositions
JP6611014B2 (en) 2013-11-22 2019-11-27 ボシュ ヘルス アイルランド リミテッド Anti-infection method, anti-infection composition, and anti-infection device
WO2015081007A1 (en) * 2013-11-26 2015-06-04 Humco Holding Group, Inc. Transdermal silicone gel (silogel) compositions and methods of preparation
US9351996B1 (en) * 2015-03-11 2016-05-31 Sayed Antar Topical cream composition
WO2017188957A1 (en) * 2016-04-28 2017-11-02 Antar Sayed Topical cream composition
US20210161870A1 (en) 2017-06-07 2021-06-03 Arcutis Biotherapeutics, Inc. Roflumilast formulations with an improved pharmacokinetic profile
US9895359B1 (en) 2017-06-07 2018-02-20 Arcutis, Inc. Inhibition of crystal growth of roflumilast
US12011437B1 (en) 2017-06-07 2024-06-18 Arcutis Biotherapeutics, Inc. Roflumilast formulations with an improved pharmacokinetic profile
US20200155524A1 (en) 2018-11-16 2020-05-21 Arcutis, Inc. Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
US11129818B2 (en) 2017-06-07 2021-09-28 Arcutis Biotherapeutics, Inc. Topical roflumilast formulation having improved delivery and plasma half life
US12042487B2 (en) 2018-11-16 2024-07-23 Arcutis Biotherapeutics, Inc. Method for reducing side effects from administration of phosphodiesterase-4 inhibitors
EP3801461A2 (en) 2018-06-04 2021-04-14 Arcutis, Inc. Method and formulation for improving roflumilast skin penetration lag time
US11337995B2 (en) * 2018-11-06 2022-05-24 Epsom-It, Inc. Peripheral neuropathy composition and related methods
US11707454B2 (en) 2020-12-04 2023-07-25 Arcutis Biotherapeutics, Inc. Topical roflumilast formulation having antifungal properties
CN118765194A (en) 2021-12-28 2024-10-11 阿尔库缇斯生物疗法股份有限公司 Topical roflumilast aerosol foam
WO2024058848A1 (en) 2022-09-15 2024-03-21 Arcutis Biotherapeutics, Inc. Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009609A1 (en) * 1993-10-07 1995-04-13 Astra Aktiebolag New emulsion formulation
US6080394A (en) * 1999-11-08 2000-06-27 Dow Corning Corporation Polar solvent-in-oil emulsions and multiple emulsions
US20020022010A1 (en) * 2000-05-08 2002-02-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions
US20020136743A1 (en) * 1996-05-17 2002-09-26 Anne Langlois Cosmetic compositions
US6537537B2 (en) * 1997-06-12 2003-03-25 The Procter & Gamble Company Water-in-silicone emulsion cosmetic compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2005109A (en) * 1930-11-26 1935-06-18 Hussmann Ligonier Company Slicing machine
GB8914905D0 (en) * 1989-06-29 1989-08-23 Unilever Plc Cosmetic composition
US5599533A (en) * 1994-12-15 1997-02-04 Estee Lauder, Inc. Stable water-in-oil emulsion system
ZA966814B (en) * 1995-08-18 1998-02-12 Colgate Palmolive Co Clear cosmetic gel composition.
US5939082A (en) * 1995-11-06 1999-08-17 The Procter & Gamble Company Methods of regulating skin appearance with vitamin B3 compound
NZ337316A (en) * 1997-03-12 2001-06-29 Abbott Lab Hydrophilic binary systems comprising cyclosporine, hydrophilic phase and a surfactant for the administration of cyclosporine
WO1999060167A1 (en) * 1998-05-21 1999-11-25 Isis Pharmaceuticals, Inc. Compositions and methods for topical delivery of oligonucleotides
US6071975A (en) * 1999-01-11 2000-06-06 Dow Corning Corporation Method of preparing silicone oil-in-water microemulsions
US6685952B1 (en) * 1999-06-25 2004-02-03 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Personal care compositions and methods-high internal phase water-in-volatile silicone oil systems
GB0106507D0 (en) * 2001-03-16 2001-05-02 Entomos Sciences Ltd Arthropodicidal compositions
US6485716B1 (en) * 2001-10-05 2002-11-26 Colgate-Palmolive Company High efficacy liquid gel product
US6861061B2 (en) * 2001-12-19 2005-03-01 Dow Corning Corporation Stabilization of vitamins in water-in silicone oil (W/O) emulsions
US20040166083A1 (en) * 2003-02-26 2004-08-26 The Andrew Jergens Company Personal care water-in-oil emulsion products

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009609A1 (en) * 1993-10-07 1995-04-13 Astra Aktiebolag New emulsion formulation
US20020136743A1 (en) * 1996-05-17 2002-09-26 Anne Langlois Cosmetic compositions
US6537537B2 (en) * 1997-06-12 2003-03-25 The Procter & Gamble Company Water-in-silicone emulsion cosmetic compositions
US6080394A (en) * 1999-11-08 2000-06-27 Dow Corning Corporation Polar solvent-in-oil emulsions and multiple emulsions
US20020022010A1 (en) * 2000-05-08 2002-02-21 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHIDAMBARAM ET AL.: "Mathematical Modeling of Surface-Active and Non-Surface-Active Drug Transport in Emulsion Systems", AAPS PHARMASCI., vol. 2, no. 3, September 2000 (2000-09-01), pages 1 - 12, XP008130325 *

Also Published As

Publication number Publication date
US20070207107A1 (en) 2007-09-06
WO2007106284A2 (en) 2007-09-20
EP1996170A2 (en) 2008-12-03

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