WO2007106536A3 - Methods for producing an immune response to tuberculosis - Google Patents

Methods for producing an immune response to tuberculosis Download PDF

Info

Publication number
WO2007106536A3
WO2007106536A3 PCT/US2007/006472 US2007006472W WO2007106536A3 WO 2007106536 A3 WO2007106536 A3 WO 2007106536A3 US 2007006472 W US2007006472 W US 2007006472W WO 2007106536 A3 WO2007106536 A3 WO 2007106536A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune response
methods
tuberculosis
producing
mtb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/006472
Other languages
French (fr)
Other versions
WO2007106536A2 (en
Inventor
David Lewinsohn
Deborah Lewinsohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
US Department of Veterans Affairs
Original Assignee
Oregon Health and Science University
US Department of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University, US Department of Veterans Affairs filed Critical Oregon Health and Science University
Priority to BRPI0708865A priority Critical patent/BRPI0708865A8/en
Priority to EP07753122A priority patent/EP1994409A2/en
Priority to US12/282,865 priority patent/US7842299B2/en
Publication of WO2007106536A2 publication Critical patent/WO2007106536A2/en
Publication of WO2007106536A3 publication Critical patent/WO2007106536A3/en
Anticipated expiration legal-status Critical
Priority to ZA2008/08643A priority patent/ZA200808643B/en
Priority to US12/894,051 priority patent/US8101192B2/en
Priority to US13/332,150 priority patent/US8440206B2/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)

Abstract

Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional embodiments, methods are disclosed for preventing an infection with Mtb, or treating an infection with Mtb. Pharmaceutical compositions for the prevention and/or treatment of tuberculosis are also disclosed.
PCT/US2007/006472 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis Ceased WO2007106536A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BRPI0708865A BRPI0708865A8 (en) 2006-03-14 2007-03-14 methods to produce an immune response to tuberculosis
EP07753122A EP1994409A2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis
US12/282,865 US7842299B2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis
ZA2008/08643A ZA200808643B (en) 2006-03-14 2008-10-09 Methods for producing an immune response to tuberculosis
US12/894,051 US8101192B2 (en) 2006-03-14 2010-09-29 Methods for producing an immune response to tuberculosis
US13/332,150 US8440206B2 (en) 2006-03-14 2011-12-20 Methods for producing an immune response to tuberculosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78236406P 2006-03-14 2006-03-14
US60/782,364 2006-03-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/282,865 A-371-Of-International US7842299B2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis
US12/894,051 Division US8101192B2 (en) 2006-03-14 2010-09-29 Methods for producing an immune response to tuberculosis

Publications (2)

Publication Number Publication Date
WO2007106536A2 WO2007106536A2 (en) 2007-09-20
WO2007106536A3 true WO2007106536A3 (en) 2008-01-10

Family

ID=38208601

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/006534 Ceased WO2007106560A2 (en) 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection
PCT/US2007/006472 Ceased WO2007106536A2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006534 Ceased WO2007106560A2 (en) 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection

Country Status (7)

Country Link
US (7) US8053181B2 (en)
EP (13) EP2441493B1 (en)
CN (1) CN101438166A (en)
BR (2) BRPI0708865A8 (en)
CA (1) CA2649688A1 (en)
WO (2) WO2007106560A2 (en)
ZA (2) ZA200808644B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1333858B8 (en) 2000-11-07 2006-06-14 Immunovaccine Technologies Inc. Vaccines with enhanced immune response and methods for their preparation
EP2441493B1 (en) * 2006-03-14 2014-05-07 Oregon Health and Science University Methods for producing an immune response to tuberculosis
JP5805368B2 (en) * 2006-09-05 2015-11-04 ステイテンス・セラム・インスティテュート Immunological monitoring based on IP-10
BRPI0604958B1 (en) * 2006-11-23 2022-05-17 Fundação Oswaldo Cruz Kit for distinguishing mycobacterium tuberculosis, m. bovis, m. bovis bcg in a sample, and method to distinguish mycobacterium tuberculosis, m. bovis, m. bovis bcg
CA2700808C (en) 2007-09-27 2017-11-14 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
ES2524699T3 (en) * 2008-06-05 2014-12-11 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a vehicle comprising a continuous phase of a hydrophobic substance
AT506819B1 (en) * 2008-06-12 2011-06-15 Affiris Forschungs Und Entwicklungs Gmbh VACCINE FOR THE TREATMENT OF ALZHEIMER DISEASE
CA2732750A1 (en) * 2008-09-22 2010-03-25 The Government Of The United States Of America D.B.A.The Department Of V Eterans Affairs Methods for detecting a mycobacterium tuberculosis infection
MX2012002545A (en) 2009-08-28 2012-04-02 Dow Global Technologies Llc Rotational molded articles, and method of making the same.
WO2011063283A2 (en) * 2009-11-20 2011-05-26 Oregon Health & Science University Methods for detecting a mycobacterium tuberculosis infection
JP6240077B2 (en) 2011-10-06 2017-11-29 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Liposome composition comprising an adjuvant that activates or increases its activity and its use
US20140349320A1 (en) * 2011-12-15 2014-11-27 The Trustees Of The University Of Pennsylvania Using Adaptive Immunity to Detect Drug Resistance
CN103864907B (en) * 2012-12-18 2016-12-28 中国医学科学院病原生物学研究所 Albumen and test kit for diagnosis of tuberculosis
CN104151411B (en) * 2013-05-14 2018-03-20 中国医学科学院病原生物学研究所 Albumen and pharmaceutical composition for diagnosis of tuberculosis
US10226522B2 (en) 2013-08-30 2019-03-12 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
US9970062B2 (en) 2015-08-06 2018-05-15 Roche Molecular Systems, Inc. Compositions and methods for detection of mycobacterium tuberculosis
CN107304231B (en) * 2016-04-18 2021-01-01 华中农业大学 A Mycobacterium tuberculosis fusion protein and application
CA3059408A1 (en) * 2016-09-22 2018-04-12 Pace Diagnostics, Inc Mycobacterium tuberculosis proteins in diagnostic assays and devices for tuberculosis detection and diagnosis
WO2018111536A1 (en) 2016-12-14 2018-06-21 Becton, Dickinson And Company Methods and compositions for obtaining a tuberculosis assessment in a subject
WO2019210282A2 (en) * 2018-04-26 2019-10-31 Children's National Medical Center Mycobacterial antigen compositions and methods of use
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN112322566A (en) * 2020-11-17 2021-02-05 中国农业科学院北京畜牧兽医研究所 Attenuated strain of Mycobacterium bovis and its application
CN116262794B (en) * 2021-12-13 2024-09-13 江苏瑞科生物技术股份有限公司 Recombinant mycobacterium tuberculosis antigen, preparation method and application thereof
WO2025106997A1 (en) * 2023-11-17 2025-05-22 The General Hospital Corporation Mycobacterium tuberculosis vaccines and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1999024577A1 (en) * 1997-11-10 1999-05-20 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US20040141985A1 (en) * 1998-12-23 2004-07-22 Isis Innovation Limited Tuberculosis vaccine
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4444487A (en) 1979-07-02 1984-04-24 Xerox Corporation Multiple-flash fuser
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4745055A (en) 1985-05-07 1988-05-17 California Biotechnology Inc. Fused protein for enzyme immunoassay system
US4895800A (en) 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
US4811254A (en) 1985-12-17 1989-03-07 Nippon Gakki Seizo Kabushiki Kaisha Displacement detector for an encoder
US5091309A (en) 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
EP0256654B1 (en) 1986-07-07 1996-09-18 Centocor, Inc. Chimeric murine/human immunoglobulin specific for tumour-associated 17-1A Antigen
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
GB8626412D0 (en) 1986-11-05 1986-12-03 Clark M R Antibodies
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
AP56A (en) 1987-01-30 1989-09-26 Smithkline Biologicals S A Hepatitis B virus surface antigens and hybrid antigehs containing them.
ES2056799T3 (en) 1987-07-17 1994-10-16 Rhein Biotech Ges Fur Biotechn CODANT DNA MOLECULES FOR THE FMDH CONTROL AND STRUCTURAL GENE REGIONS FOR A PROTEIN THAT HAS AN FMDH ACTIVITY AND ITS USE.
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
DE10399032I1 (en) 1987-08-28 2004-01-29 Health Research Inc Recombinant viruses.
CA1340203C (en) 1987-09-16 1998-12-15 Noboru Yanagida Recombinant apivoxvirus
AU622426B2 (en) 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
JPH0630628B2 (en) 1987-12-16 1994-04-27 キング醸造株式会社 Method for measuring the number of viable cells and vitality
US4957795A (en) 1988-05-13 1990-09-18 Minnesota Mining And Manufacturing Company Absorbent elastomeric wound dressing
JP2955759B2 (en) 1988-07-20 1999-10-04 セゲブ・ダイアグノスティックス・インコーポレイテッド Methods for amplifying and detecting nucleic acid sequences
US5093258A (en) 1988-08-26 1992-03-03 Therion Biologics Corporation Recombinant fowlpox virus and recombination vector
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5188937A (en) 1989-04-06 1993-02-23 Becton, Dickinson And Company Layered sandwich assay method for chlamydia and materials therefor
US5270202A (en) 1989-11-03 1993-12-14 Syamal Raychaudhuri Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
GB9007024D0 (en) 1990-03-29 1990-05-30 Imperial College Novel vaccine
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
WO1991019803A1 (en) 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
US5709860A (en) 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
WO1993001831A1 (en) 1991-07-25 1993-02-04 Idec Pharmaceuticals Corporation Induction of cytotoxic t-lymphocyte responses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
AU668384B2 (en) 1992-03-12 1996-05-02 Alkermes Controlled Therapeutics, Inc. Controlled release ACTH containing microspheres
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5662907A (en) 1992-08-07 1997-09-02 Cytel Corporation Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
DE69332485T2 (en) 1992-08-11 2003-11-13 The President And Fellows Of Harvard College, Cambridge Immunomodulatory peptides
FR2698877B1 (en) 1992-12-04 1995-04-07 Atochem Elf Sa Composition hot-melt adhesive crosslinkable to moisture.
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US6991797B2 (en) * 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
ATE509102T1 (en) 1994-07-15 2011-05-15 Univ Iowa Res Found IMMUNOMODULATORY OLIGONUCLEOTIDES
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DE69524105T2 (en) 1994-07-15 2002-07-18 Organon Teknika B.V., Boxtel USE OF RNA POLYMERASE TO IMPROVE NUKEIC ACID AMPLIFICATION PROCESS
US6045802A (en) 1994-10-03 2000-04-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
JP3907698B2 (en) 1994-10-03 2007-04-18 アメリカ合衆国 A composition comprising a recombinant virus expressing an antigen and a recombinant virus expressing an immunostimulatory molecule
US5736524A (en) * 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
AT402203B (en) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr METHOD FOR TRANSCRIPTION-FREE AMPLIFICATION OF NUCLEIC ACIDS
US6165460A (en) 1995-07-10 2000-12-26 Therion Biologics Corporation Generation of immune responses to prostate-specific antigen (PSA)
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
CA2285625C (en) * 1997-04-02 2015-06-30 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis
US7037510B2 (en) 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US6555653B2 (en) 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
AU7690898A (en) 1997-05-20 1998-12-11 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
ATE356630T1 (en) 1998-04-03 2007-04-15 Univ Iowa Res Found METHOD AND PRODUCTS FOR STIMULATING THE IMMUNE SYSTEM USING IMMUNOTHERAPEUTIC OLIGONUCLEOTIDES AND CYTOKINE
US6294328B1 (en) 1998-06-24 2001-09-25 The Institute For Genomic Research DNA sequences for strain analysis in Mycobacterium tuberculosis
ATE429245T1 (en) * 1999-05-04 2009-05-15 Univ New Jersey Med PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES
CA2383213A1 (en) 1999-09-10 2001-03-15 Fordham University Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins
US6861513B2 (en) 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
US20020061569A1 (en) 2000-03-21 2002-05-23 Robert Haselbeck Identification of essential genes in prokaryotes
US7657378B1 (en) * 2000-03-30 2010-02-02 Council Of Scientific & Industrial Research Computer based method for identifying peptides useful as drug targets
WO2001079257A2 (en) 2000-04-14 2001-10-25 Phytera, Inc. Multidrug resistance (mdr) efflux pump polypeptides
KR100464485B1 (en) 2000-11-09 2004-12-31 엘지전자 주식회사 A method and a device of transmitting high-speed packet data
CA2430896A1 (en) 2000-12-13 2002-06-20 Argonex Pharmaceuticals, Inc. Mhc class i associated peptides for prevention and treatment of tuberculosis
AU2002306849A1 (en) * 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
FI116851B (en) * 2001-05-03 2006-03-15 Fit Biotech Oyj Plc Expression vector, its uses and process for its preparation and products containing it
US7067492B2 (en) * 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
GB0124593D0 (en) 2001-10-12 2001-12-05 Microbiological Res Authority Mycobacterial antigens expressed under high oxygen tension
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
AU2002347346A1 (en) 2001-12-07 2003-06-17 University Of Liverpool Dna vaccine
GB2398302B (en) 2002-02-08 2005-10-19 All India Inst Med A process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
US7074559B2 (en) 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
US20030236393A1 (en) * 2002-03-22 2003-12-25 United States Of America Dept Of Vetrans Affairs Virulence genes of M. marinum and M. tuberculosis
AU2003242504A1 (en) 2002-07-13 2004-02-02 Statens Serum Institut Therapeutic tuberculosis vaccines
US7364869B2 (en) * 2003-07-29 2008-04-29 The J. David Gladstone Institutes Method of detecting antigen-specific T lymphocytes
ITRM20030411A1 (en) * 2003-08-29 2005-02-28 Consiglio Nazionale Ricerche USE OF SPECIFIC GENE SEQUENCES OF MYCOBACTERIUM TUBERCOLOSIS IN ADDITIONAL PROTEINS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION.
EP1518932A1 (en) * 2003-09-29 2005-03-30 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Modified vaccinia virus Ankara (MVA) mutant and use thereof
EP1721283B1 (en) * 2004-02-06 2022-11-30 Council of Scientific and Industrial Research Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential
GB0406271D0 (en) * 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
US20090070897A1 (en) 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement
US7566459B2 (en) * 2005-02-28 2009-07-28 New York University Modified mycobacterium tuberculosis strains and uses thereof
EP2426141B1 (en) * 2005-04-29 2014-10-01 GlaxoSmithKline Biologicals S.A. Method for preventing or treating M tuberculosis infection
US7968694B2 (en) * 2005-07-01 2011-06-28 Forsyth Dental Infirmary For Children Tuberculosis antigen detection assays and vaccines
EP2441493B1 (en) * 2006-03-14 2014-05-07 Oregon Health and Science University Methods for producing an immune response to tuberculosis
KR100756676B1 (en) * 2006-11-23 2007-09-07 제일모직주식회사 Silicone microparticles | fine-particles, its manufacturing method, and the thermoplastic resin composition containing this microparticles | fine-particles
ES2621211T3 (en) 2007-04-04 2017-07-03 Infectious Disease Research Institute Immunogenic compositions comprising mycobacterium tuberculosis polypeptides and fusions thereof
US10611818B2 (en) * 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
MX2011000982A (en) * 2008-07-25 2011-03-02 Glaxosmithkline Biolog Sa The tuberculosis rv2386c protein, compositions and uses thereof.
KR101598876B1 (en) * 2008-07-25 2016-03-02 디파트먼트 오브 바이오테크놀러지 Constructing a dna chimera for vaccine development against leishmaniasis and tuberculosis
CA2732750A1 (en) 2008-09-22 2010-03-25 The Government Of The United States Of America D.B.A.The Department Of V Eterans Affairs Methods for detecting a mycobacterium tuberculosis infection
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US8691502B2 (en) * 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
WO2011063283A2 (en) * 2009-11-20 2011-05-26 Oregon Health & Science University Methods for detecting a mycobacterium tuberculosis infection
US10703784B2 (en) * 2011-09-30 2020-07-07 La Jolla Institute For Allergy And Immunology Antigens and epitopes derived from Mycobacterium tuberculosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053075A2 (en) * 1997-05-20 1998-11-26 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1999024577A1 (en) * 1997-11-10 1999-05-20 Statens Serum Institut NUCLEIC ACID FRAGMENTS AND POLYPEPTIDE FRAGMENTS DERIVED FROM $i(M. TUBERCULOSIS)
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
US20040141985A1 (en) * 1998-12-23 2004-07-22 Isis Innovation Limited Tuberculosis vaccine
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FLEISCHMANN R D ET AL: "Whole genome comparison of Mycobacterium tuberculosis clinical and laboratory strains", EMBL, 2002, XP002205726 *
FLEISCHMANN R D ET AL: "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 184, no. 19, October 2002 (2002-10-01), pages 5479 - 5490, XP002412257, ISSN: 0021-9193 *
GROTZKE J E ET AL: "Role of CD8<+> T lymphocytes in control of Mycobacterium tuberculosis infection", MICROBES AND INFECTION, ELSEVIER, PARIS, FR, vol. 7, no. 4, April 2005 (2005-04-01), pages 776 - 788, XP004904672, ISSN: 1286-4579 *
LEWINSOHN DAVID M ET AL: "Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 10, 18 May 1998 (1998-05-18), pages 1633 - 1640, XP002443627, ISSN: 0022-1007 *
LEWINSOHN DEBORAH A ET AL: "Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis-specific CD8+ T cells", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 166, no. 6, 15 September 2002 (2002-09-15), pages 843 - 848, XP002443626, ISSN: 1073-449X *

Also Published As

Publication number Publication date
US20130101523A1 (en) 2013-04-25
ZA200808644B (en) 2017-08-30
EP2397852A2 (en) 2011-12-21
US20090124549A1 (en) 2009-05-14
EP2207035B1 (en) 2013-10-16
WO2007106536A2 (en) 2007-09-20
US20120107341A1 (en) 2012-05-03
EP2207035A3 (en) 2010-11-17
EP2397854A2 (en) 2011-12-21
EP2397856A2 (en) 2011-12-21
US8440206B2 (en) 2013-05-14
EP2428801B1 (en) 2014-05-07
US7842299B2 (en) 2010-11-30
EP2005184A2 (en) 2008-12-24
US20120014881A1 (en) 2012-01-19
BRPI0708912B8 (en) 2021-07-27
EP2397855A2 (en) 2011-12-21
US20150219645A1 (en) 2015-08-06
EP2397854B1 (en) 2014-06-04
CA2649688A1 (en) 2007-09-20
US8361707B2 (en) 2013-01-29
WO2007106560A3 (en) 2007-12-13
CN101438166A (en) 2009-05-20
EP2397853A2 (en) 2011-12-21
EP2441493A1 (en) 2012-04-18
EP2253957A1 (en) 2010-11-24
EP2441493B1 (en) 2014-05-07
US20110014224A1 (en) 2011-01-20
EP2207035A2 (en) 2010-07-14
US8101192B2 (en) 2012-01-24
EP2441470A1 (en) 2012-04-18
ZA200808643B (en) 2014-03-26
EP2428801A1 (en) 2012-03-14
BRPI0708912A2 (en) 2011-06-14
BRPI0708865A8 (en) 2019-01-22
EP2253957B1 (en) 2013-05-15
EP2397855A3 (en) 2012-03-14
WO2007106560A2 (en) 2007-09-20
US8053181B2 (en) 2011-11-08
EP2397852B1 (en) 2013-12-04
EP2397854A3 (en) 2012-03-14
EP2397856B1 (en) 2013-11-13
EP2397853A3 (en) 2012-03-14
BRPI0708912B1 (en) 2018-03-20
EP2441470B1 (en) 2014-05-07
BRPI0708865A2 (en) 2011-06-14
US20090324503A1 (en) 2009-12-31
EP2397852A3 (en) 2012-03-14
EP1994409A2 (en) 2008-11-26
EP2441469A1 (en) 2012-04-18
EP2397856A3 (en) 2012-03-14
EP2397853B1 (en) 2014-01-15
US9040233B2 (en) 2015-05-26

Similar Documents

Publication Publication Date Title
WO2007106536A3 (en) Methods for producing an immune response to tuberculosis
WO2011063263A3 (en) Methods for producing an immune response to tuberculosis
WO2007140002A3 (en) Method for treating non-hodgkin&#39;s lymphoma
WO2008005651A3 (en) Cyclic carboxylic acid rhodanine derivatives for the treatment and prevention of tuberculosis
WO2010092123A8 (en) Sglt-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia
WO2007109192A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007109154A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2007113222A3 (en) Immunogenic composition
WO2006127883A3 (en) Personal care compositions comprising saccharide-siloxane copolymers
WO2007126824A3 (en) Methods and systems for sterilization
WO2008030505A3 (en) Methods and compositions for the treatment of antibody mediated neuropathies
WO2007109160A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2008066784A3 (en) Expression of foxp3 by cancer cells
WO2007109182A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
WO2009117230A3 (en) Methods for making components having improved erosion resistance
WO2007107488A3 (en) Vaccine against trypanosoma cruzi infection
WO2008085875A3 (en) R-zileuton for use in conditions associated with increased 5-lipoxygenase and/or leukotriene activity (eg asthma)
WO2008047061A3 (en) Cosmetic oral and/or parenteral use of glucosamine optionally in combination with at least one polyphenol compound, and corresponding composition
AU2007231133A8 (en) Buprenorphine derivatives and uses thereof
WO2008105826A3 (en) Compositions compromising lysostaphin variants and methods of using the same
WO2010134827A9 (en) Extended acting oxygen generating composition for treating microbial infections
WO2008057158A3 (en) Novel neutralizing immunogen (nimiv) of rhinovirus and its use for vaccine applications
WO2008051793A3 (en) Method of preventing or treating metabolic syndrome
WO2007115287A3 (en) Combination of organic compounds
WO2008073317A3 (en) Cytarabine for treatment of glioma

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 12282865

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 3959/KOLNP/2008

Country of ref document: IN

Ref document number: 2007753122

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07753122

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 200780016660.7

Country of ref document: CN

ENP Entry into the national phase

Ref document number: PI0708865

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20080912