WO2007106560A3 - Methods for detecting a mycobacterium tuberculosis infection - Google Patents

Methods for detecting a mycobacterium tuberculosis infection Download PDF

Info

Publication number
WO2007106560A3
WO2007106560A3 PCT/US2007/006534 US2007006534W WO2007106560A3 WO 2007106560 A3 WO2007106560 A3 WO 2007106560A3 US 2007006534 W US2007006534 W US 2007006534W WO 2007106560 A3 WO2007106560 A3 WO 2007106560A3
Authority
WO
WIPO (PCT)
Prior art keywords
detecting
methods
mtb
mycobacterium tuberculosis
tuberculosis infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/006534
Other languages
French (fr)
Other versions
WO2007106560A2 (en
Inventor
David Lewinsohn
Deborah Lewinsohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
US Department of Veterans Affairs
Original Assignee
Oregon Health and Science University
US Department of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University, US Department of Veterans Affairs filed Critical Oregon Health and Science University
Priority to EP07753181A priority Critical patent/EP2005184A2/en
Priority to CA002649688A priority patent/CA2649688A1/en
Priority to BRPI0708912A priority patent/BRPI0708912B8/en
Priority to US12/282,862 priority patent/US8053181B2/en
Publication of WO2007106560A2 publication Critical patent/WO2007106560A2/en
Publication of WO2007106560A3 publication Critical patent/WO2007106560A3/en
Anticipated expiration legal-status Critical
Priority to ZA2008/08644A priority patent/ZA200808644B/en
Priority to US13/244,126 priority patent/US8361707B2/en
Priority to US13/719,124 priority patent/US9040233B2/en
Priority to US14/693,609 priority patent/US20150219645A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)

Abstract

Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed. The methods include detecting the presence of CD8+ T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+ T cells in a biological sample, and in vivo assays that detect a delayed type hypersensitivity reaction. The methods can also' include detecting Mtb polypeptides and polynucleotides. Reagents for the detection of an Mtb infection are also disclosed.
PCT/US2007/006534 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection Ceased WO2007106560A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP07753181A EP2005184A2 (en) 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection
CA002649688A CA2649688A1 (en) 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection
BRPI0708912A BRPI0708912B8 (en) 2006-03-14 2007-03-14 in vitro methods for detecting mycobacterium tuberculosis and cd8 expressing t cells that specifically recognize seq id no: 11 in an individual
US12/282,862 US8053181B2 (en) 2006-03-14 2007-03-14 Methods for detecting a Mycobacterium tuberculosis infection
ZA2008/08644A ZA200808644B (en) 2006-03-14 2008-10-09 Methods for detecting a mycobacterium tuberculosis infection
US13/244,126 US8361707B2 (en) 2006-03-14 2011-09-23 Methods for detecting a Mycobacterium tuberculosis infection
US13/719,124 US9040233B2 (en) 2006-03-14 2012-12-18 Methods for detecting a Mycobacterium tuberculosis infection
US14/693,609 US20150219645A1 (en) 2006-03-14 2015-04-22 Methods for detecting a mycobacterium tuberculosis infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78236406P 2006-03-14 2006-03-14
US60/782,364 2006-03-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/282,862 A-371-Of-International US8053181B2 (en) 2006-03-14 2007-03-14 Methods for detecting a Mycobacterium tuberculosis infection
US13/244,126 Continuation US8361707B2 (en) 2006-03-14 2011-09-23 Methods for detecting a Mycobacterium tuberculosis infection

Publications (2)

Publication Number Publication Date
WO2007106560A2 WO2007106560A2 (en) 2007-09-20
WO2007106560A3 true WO2007106560A3 (en) 2007-12-13

Family

ID=38208601

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/006472 Ceased WO2007106536A2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis
PCT/US2007/006534 Ceased WO2007106560A2 (en) 2006-03-14 2007-03-14 Methods for detecting a mycobacterium tuberculosis infection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006472 Ceased WO2007106536A2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis

Country Status (7)

Country Link
US (7) US8053181B2 (en)
EP (13) EP2207035B1 (en)
CN (1) CN101438166A (en)
BR (2) BRPI0708912B8 (en)
CA (1) CA2649688A1 (en)
WO (2) WO2007106536A2 (en)
ZA (2) ZA200808644B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2428103C (en) * 2000-11-07 2015-06-09 Immunovaccine Technologies Inc. Vaccines with enhanced immune response and methods for their preparation
EP2207035B1 (en) 2006-03-14 2013-10-16 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
ATE504000T1 (en) * 2006-09-05 2011-04-15 Hvidovre Hospital IP-10 BASED IMMUNOLOGICAL MONITORING
BRPI0604958B1 (en) * 2006-11-23 2022-05-17 Fundação Oswaldo Cruz Kit for distinguishing mycobacterium tuberculosis, m. bovis, m. bovis bcg in a sample, and method to distinguish mycobacterium tuberculosis, m. bovis, m. bovis bcg
JP5731198B2 (en) 2007-09-27 2015-06-10 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Use of liposomes in carriers containing a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
CN102056622B (en) * 2008-06-05 2016-04-06 免疫疫苗技术有限公司 Composition comprising liposome, antigen, polynucleotide and carrier comprising a continuous phase of hydrophobic substance
AT506819B1 (en) * 2008-06-12 2011-06-15 Affiris Forschungs Und Entwicklungs Gmbh VACCINE FOR THE TREATMENT OF ALZHEIMER DISEASE
EP2353008A2 (en) 2008-09-22 2011-08-10 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
BR112012003539A2 (en) 2009-08-28 2017-05-23 Dow Global Technologies Llc rotational molded article and process for manufacturing an article
EP3360566B1 (en) * 2009-11-20 2019-12-25 Oregon Health&Science University Methods for detecting a mycobacterium tuberculosis infection
CN113876945A (en) 2011-10-06 2022-01-04 免疫疫苗技术有限公司 Liposome composition comprising adjuvant for activating or increasing TLR2 activity and application thereof
WO2013090897A1 (en) * 2011-12-15 2013-06-20 The Trustees Of The University Of Pennsylvania Using adaptive immunity to detect drug resistance
CN103864907B (en) * 2012-12-18 2016-12-28 中国医学科学院病原生物学研究所 Albumen and test kit for diagnosis of tuberculosis
CN104151411B (en) * 2013-05-14 2018-03-20 中国医学科学院病原生物学研究所 Albumen and pharmaceutical composition for diagnosis of tuberculosis
WO2015031778A2 (en) * 2013-08-30 2015-03-05 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
US9970062B2 (en) 2015-08-06 2018-05-15 Roche Molecular Systems, Inc. Compositions and methods for detection of mycobacterium tuberculosis
CN107304231B (en) * 2016-04-18 2021-01-01 华中农业大学 A Mycobacterium tuberculosis fusion protein and application
EP4257976A3 (en) * 2016-09-22 2024-01-24 Pace Diagnostics, Inc Mycobacterium tuberculosis proteins in diagnostic assays and devices for tuberculosis detection and diagnosis
ES2950436T3 (en) 2016-12-14 2023-10-10 Becton Dickinson Co Methods and compositions to obtain an assessment of tuberculosis in a subject
JP2021522245A (en) * 2018-04-26 2021-08-30 チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Mycobacterial antigen composition and usage
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN112322566A (en) * 2020-11-17 2021-02-05 中国农业科学院北京畜牧兽医研究所 Attenuated strain of Mycobacterium bovis and its application
CN116262794B (en) * 2021-12-13 2024-09-13 江苏瑞科生物技术股份有限公司 Recombinant mycobacterium tuberculosis antigen, preparation method and application thereof
WO2025106997A1 (en) * 2023-11-17 2025-05-22 The General Hospital Corporation Mycobacterium tuberculosis vaccines and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US20040141985A1 (en) * 1998-12-23 2004-07-22 Isis Innovation Limited Tuberculosis vaccine
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4444487A (en) 1979-07-02 1984-04-24 Xerox Corporation Multiple-flash fuser
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4745055A (en) 1985-05-07 1988-05-17 California Biotechnology Inc. Fused protein for enzyme immunoassay system
US4895800A (en) 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
US4811254A (en) 1985-12-17 1989-03-07 Nippon Gakki Seizo Kabushiki Kaisha Displacement detector for an encoder
US5091309A (en) 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
CA1340456C (en) 1986-07-07 1999-03-23 Hubert J.P. Schoemaker Chimeric rodent/human immunoglobulins specific for tumor-associated antigens
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
GB8626412D0 (en) 1986-11-05 1986-12-03 Clark M R Antibodies
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0278940A3 (en) 1987-01-30 1988-12-07 Smithkline Biologicals S.A. Hepatitis b virus surface antigens and hybrid antigens containing them
EP0299108B1 (en) 1987-07-17 1994-05-18 Rhein Biotech Gesellschaft für biotechnologische Prozesse und Produkte mbH DNA-molecules coding for FMDH control regions and structured gene for a protein having FMDH-activity and their uses
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
DE10399031I1 (en) 1987-08-28 2004-01-29 Health Research Inc Recombinant viruses.
CA1340203C (en) 1987-09-16 1998-12-15 Noboru Yanagida Recombinant apivoxvirus
AU622426B2 (en) 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
JPH0630628B2 (en) 1987-12-16 1994-04-27 キング醸造株式会社 Method for measuring the number of viable cells and vitality
US4957795A (en) 1988-05-13 1990-09-18 Minnesota Mining And Manufacturing Company Absorbent elastomeric wound dressing
WO1990001069A1 (en) 1988-07-20 1990-02-08 Segev Diagnostics, Inc. Process for amplifying and detecting nucleic acid sequences
US5093258A (en) 1988-08-26 1992-03-03 Therion Biologics Corporation Recombinant fowlpox virus and recombination vector
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5188937A (en) 1989-04-06 1993-02-23 Becton, Dickinson And Company Layered sandwich assay method for chlamydia and materials therefor
US5270202A (en) 1989-11-03 1993-12-14 Syamal Raychaudhuri Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
GB9007024D0 (en) 1990-03-29 1990-05-30 Imperial College Novel vaccine
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
WO1991019803A1 (en) 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
ATE166578T1 (en) 1991-07-25 1998-06-15 Idec Pharma Corp STIMULATION OF RESPONSES OF CYTOTOXIC T-LYMPHOCYTES
US5709860A (en) 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
EP0630234B1 (en) 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5662907A (en) 1992-08-07 1997-09-02 Cytel Corporation Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
CA2142007C (en) 1992-08-11 2007-10-30 Robert Glen Urban Immunomodulatory peptides
FR2698877B1 (en) 1992-12-04 1995-04-07 Atochem Elf Sa Composition hot-melt adhesive crosslinkable to moisture.
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US6991797B2 (en) * 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
WO1996002555A1 (en) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
EP0776376B1 (en) 1994-07-15 2001-11-21 Akzo Nobel N.V. Use of rna polymerase to improve nucleic acid amplification process
US6045802A (en) 1994-10-03 2000-04-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
WO1996010419A2 (en) 1994-10-03 1996-04-11 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, Office Of Technology Transfer Composition comprising a recombinant virus expressing an antigen and a recombinant virus expressing an immunostimulatory molecule
US5736524A (en) * 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
AT402203B (en) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr METHOD FOR TRANSCRIPTION-FREE AMPLIFICATION OF NUCLEIC ACIDS
US6165460A (en) 1995-07-10 2000-12-26 Therion Biologics Corporation Generation of immune responses to prostate-specific antigen (PSA)
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
PT1449922E (en) * 1997-04-02 2007-11-09 Statens Seruminstitut Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis
US7037510B2 (en) * 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
AU7690898A (en) 1997-05-20 1998-12-11 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
US6555653B2 (en) * 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
EP1029053A1 (en) 1997-11-10 2000-08-23 Statens Seruminstitut Nucleic acid fragments and polypeptide fragments derived from mycobacterium tuberculosis
US6218371B1 (en) 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
US6294328B1 (en) * 1998-06-24 2001-09-25 The Institute For Genomic Research DNA sequences for strain analysis in Mycobacterium tuberculosis
ES2326257T3 (en) * 1999-05-04 2009-10-06 The University Of Medicine And Dentistry Of New Jersey PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND ITS USE AS DIAGNOSTIC REAGENTS AND VACCINES.
EP1218030A4 (en) 1999-09-10 2004-09-15 Univ Fordham METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF GRAFT REJECTS USING THERMAL SHOCK PROTEINS
US6861513B2 (en) * 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
KR20020097200A (en) 2000-03-21 2002-12-31 엘리트라 파마슈티컬즈, 인코포레이티드 Identification of essential genes in prokaryotes
US7657378B1 (en) 2000-03-30 2010-02-02 Council Of Scientific & Industrial Research Computer based method for identifying peptides useful as drug targets
AU2001253508A1 (en) * 2000-04-14 2001-10-30 Phytera, Inc. Mdr efflux pumps
KR100464485B1 (en) 2000-11-09 2004-12-31 엘지전자 주식회사 A method and a device of transmitting high-speed packet data
CA2430896A1 (en) * 2000-12-13 2002-06-20 Argonex Pharmaceuticals, Inc. Mhc class i associated peptides for prevention and treatment of tuberculosis
AU2002306849A1 (en) * 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
FI116851B (en) * 2001-05-03 2006-03-15 Fit Biotech Oyj Plc Expression vector, its uses and process for its preparation and products containing it
US7067492B2 (en) * 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
GB0124593D0 (en) 2001-10-12 2001-12-05 Microbiological Res Authority Mycobacterial antigens expressed under high oxygen tension
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20050123511A1 (en) * 2001-12-07 2005-06-09 Mccreavy David T. Dna vaccine
JP4229238B2 (en) * 2002-02-08 2009-02-25 ザ ディレクター、オール インディア インスチチュート オブ メディカル サイエンス Methods for identifying novel targets for use in the development of tuberculosis treatments and drugs
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
US20030236393A1 (en) * 2002-03-22 2003-12-25 United States Of America Dept Of Vetrans Affairs Virulence genes of M. marinum and M. tuberculosis
EP1523331B1 (en) * 2002-07-13 2013-02-27 Statens Serum Institut Therapeutic tb vaccine
US7364869B2 (en) * 2003-07-29 2008-04-29 The J. David Gladstone Institutes Method of detecting antigen-specific T lymphocytes
ITRM20030411A1 (en) * 2003-08-29 2005-02-28 Consiglio Nazionale Ricerche USE OF SPECIFIC GENE SEQUENCES OF MYCOBACTERIUM TUBERCOLOSIS IN ADDITIONAL PROTEINS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION.
EP1518932A1 (en) * 2003-09-29 2005-03-30 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Modified vaccinia virus Ankara (MVA) mutant and use thereof
KR101178776B1 (en) * 2004-02-06 2012-09-07 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 A computer apparatus for identifying adhesin and adhesin-like proteins of therapeutic potential
GB0406271D0 (en) * 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
US20090070897A1 (en) * 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement
US7566459B2 (en) * 2005-02-28 2009-07-28 New York University Modified mycobacterium tuberculosis strains and uses thereof
SI2457926T1 (en) * 2005-04-29 2015-01-30 Glaxosmithkline Biologicals S.A. Novel method for preventing or treating M. tuberculosis infection
EP2305701A1 (en) * 2005-07-01 2011-04-06 Forsyth Dental Infirmary for Children Tuberculosis antigen detection assays and vaccines
EP2207035B1 (en) * 2006-03-14 2013-10-16 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
KR100756676B1 (en) * 2006-11-23 2007-09-07 제일모직주식회사 Silicone microparticles | fine-particles, its manufacturing method, and the thermoplastic resin composition containing this microparticles | fine-particles
BRPI0809926B8 (en) * 2007-04-04 2021-05-25 Infectious Disease Res Inst composition comprising antigens from mycobacterium tuberculosis, isolated fusion polypeptide, isolated polynucleotide encoding said polypeptide, and use of said composition to stimulate a protective immune response
US10611818B2 (en) * 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
PT2315834T (en) * 2008-07-25 2018-08-10 Glaxosmithkline Biologicals Sa The tuberculosis rv2386c protein, compositions and uses thereof
WO2010010577A1 (en) * 2008-07-25 2010-01-28 Department Of Biotechnology Constructing a dna chimera for vaccine development against leishmaniasis and tuberculosis
EP2353008A2 (en) * 2008-09-22 2011-08-10 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US8691502B2 (en) * 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
EP3360566B1 (en) * 2009-11-20 2019-12-25 Oregon Health&Science University Methods for detecting a mycobacterium tuberculosis infection
US10703784B2 (en) * 2011-09-30 2020-07-07 La Jolla Institute For Allergy And Immunology Antigens and epitopes derived from Mycobacterium tuberculosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
US20040141985A1 (en) * 1998-12-23 2004-07-22 Isis Innovation Limited Tuberculosis vaccine
WO2001062893A2 (en) * 2000-02-25 2001-08-30 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GROTZKE J E ET AL: "Role of CD8<+> T lymphocytes in control of Mycobacterium tuberculosis infection", MICROBES AND INFECTION, ELSEVIER, PARIS, FR, vol. 7, no. 4, April 2005 (2005-04-01), pages 776 - 788, XP004904672, ISSN: 1286-4579 *
LEWINSOHN DAVID M ET AL: "Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 10, 18 May 1998 (1998-05-18), pages 1633 - 1640, XP002443627, ISSN: 0022-1007 *
LEWINSOHN DEBORAH A ET AL: "Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis-specific CD8+ T cells", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 166, no. 6, 15 September 2002 (2002-09-15), pages 843 - 848, XP002443626, ISSN: 1073-449X *
SMITH S M ET AL: "Human CD8+ CTL specific for the Mycobacterial major secreted antigen 85A", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 165, 2000, pages 7088 - 7095, XP002173902, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
US20120107341A1 (en) 2012-05-03
BRPI0708865A8 (en) 2019-01-22
EP2441469A1 (en) 2012-04-18
WO2007106536A2 (en) 2007-09-20
EP2207035B1 (en) 2013-10-16
US8053181B2 (en) 2011-11-08
US20120014881A1 (en) 2012-01-19
EP2397852B1 (en) 2013-12-04
EP2005184A2 (en) 2008-12-24
BRPI0708865A2 (en) 2011-06-14
WO2007106536A3 (en) 2008-01-10
US20130101523A1 (en) 2013-04-25
EP2428801A1 (en) 2012-03-14
BRPI0708912A2 (en) 2011-06-14
ZA200808644B (en) 2017-08-30
BRPI0708912B8 (en) 2021-07-27
EP2397854A2 (en) 2011-12-21
EP2397855A3 (en) 2012-03-14
US20090124549A1 (en) 2009-05-14
EP2397856A2 (en) 2011-12-21
EP2253957B1 (en) 2013-05-15
US20110014224A1 (en) 2011-01-20
EP2397854B1 (en) 2014-06-04
EP2397853A3 (en) 2012-03-14
US20090324503A1 (en) 2009-12-31
BRPI0708912B1 (en) 2018-03-20
EP2441493B1 (en) 2014-05-07
US8440206B2 (en) 2013-05-14
EP2397852A3 (en) 2012-03-14
US9040233B2 (en) 2015-05-26
EP2428801B1 (en) 2014-05-07
EP2397853A2 (en) 2011-12-21
EP2397855A2 (en) 2011-12-21
EP2397854A3 (en) 2012-03-14
EP2441470B1 (en) 2014-05-07
EP2397852A2 (en) 2011-12-21
US8361707B2 (en) 2013-01-29
CA2649688A1 (en) 2007-09-20
EP2207035A2 (en) 2010-07-14
EP2441493A1 (en) 2012-04-18
EP2253957A1 (en) 2010-11-24
EP2207035A3 (en) 2010-11-17
ZA200808643B (en) 2014-03-26
EP1994409A2 (en) 2008-11-26
WO2007106560A2 (en) 2007-09-20
EP2397856B1 (en) 2013-11-13
EP2441470A1 (en) 2012-04-18
CN101438166A (en) 2009-05-20
US20150219645A1 (en) 2015-08-06
US8101192B2 (en) 2012-01-24
US7842299B2 (en) 2010-11-30
EP2397856A3 (en) 2012-03-14
EP2397853B1 (en) 2014-01-15

Similar Documents

Publication Publication Date Title
EP2397853A3 (en) Methods for detecting a mycobacterium tuberculosis infection
WO2011063283A3 (en) Methods for detecting a mycobacterium tuberculosis infection
EP2484781A3 (en) Detection of analytes and nucleic acids
EP2385371A3 (en) Methods for detecting a mycobacterium tuberculosis infection
WO2006080024A3 (en) Device, system and method for in vivo analysis
EP2266996A3 (en) New labelling strategies for the sensitive detection of analytes
WO2008038000A8 (en) Diagnostic method for detecting or monitoring cancer
WO2010107654A3 (en) Split flow device for analyses of specific-binding partners
WO2008119081A8 (en) System and method for high resolution analysis of nucleic acids to detect sequence variations
EP2031376A3 (en) Assay device with shared zones
WO2007133586A3 (en) Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
NZ594751A (en) Method of diagnosis of infection by mycobacteria and reagents therefor
WO2002077604A3 (en) Labeled cells for use as an internal functional control in rare cell detection assays
WO2003039483A3 (en) An enzyme-based system and sensor for measuring acetone
WO2001071041A3 (en) Microarray-based analysis of polynucleotide sequence variations
WO2009006447A3 (en) Detecting and mixing in a conduit in integrated bioanalysis systems
WO2008028086A9 (en) Methods and substances for isolation and detection of small polynucleotides
WO2003020878A3 (en) Amplification and detection reagents for hiv-1
WO2008048508A3 (en) Prognostic biomarkers in patients with ovarian cancer
WO2013009084A3 (en) Composition for simultaneously detecting mycobacterium tuberculosis and nontuberculous mycobacteria by means of real-time multiplex polymerase chain reaction comprising nested hybridization pna probe system having parallel binding structure, and method for detection using same
WO2007046825A3 (en) Optoelectronic detection system
WO2008124091A3 (en) Compositions and methods of detection
WO2008054480A3 (en) Enhanced biohazard detection system
WO2005121361A3 (en) Sequence-specific detection of methylation in biomolecules
EP1249503A3 (en) Multiplexed gene analysis on a mobile solid support

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07753181

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2649688

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 3761/KOLNP/2008

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007753181

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12282862

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0708912

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20080912