WO2007107714A3 - Clinical correlates - Google Patents

Clinical correlates Download PDF

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Publication number
WO2007107714A3
WO2007107714A3 PCT/GB2007/000934 GB2007000934W WO2007107714A3 WO 2007107714 A3 WO2007107714 A3 WO 2007107714A3 GB 2007000934 W GB2007000934 W GB 2007000934W WO 2007107714 A3 WO2007107714 A3 WO 2007107714A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
secrete
intracellular pathogen
clinical correlates
ifn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/000934
Other languages
French (fr)
Other versions
WO2007107714A2 (en
WO2007107714A8 (en
Inventor
Ajit Lalvani
Kerry Millington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008558905A priority Critical patent/JP5258584B2/en
Priority to PL07712923T priority patent/PL2005182T3/en
Priority to AU2007228598A priority patent/AU2007228598A1/en
Priority to ES07712923T priority patent/ES2423479T3/en
Priority to DK07712923.7T priority patent/DK2005182T3/en
Priority to US12/293,249 priority patent/US8765366B2/en
Application filed by Individual filed Critical Individual
Priority to EP07712923.7A priority patent/EP2005182B1/en
Publication of WO2007107714A2 publication Critical patent/WO2007107714A2/en
Publication of WO2007107714A3 publication Critical patent/WO2007107714A3/en
Anticipated expiration legal-status Critical
Publication of WO2007107714A8 publication Critical patent/WO2007107714A8/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/55—IL-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/555—Interferons [IFN]
    • G01N2333/57—IFN-gamma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method of assessing an intracellular pathogen infection and/or monitoring an intracellular pathogen infection in an individual comprises determining whether the individual has (a) T-cells that secrete IFN-γ only, (b) T-cells that secrete IL-2 only or (c) T-cells that secrete both IFN-γ and IL-2 in response to an intracellular pathogen antigen and optionally determining any change in this cytokine profile.
PCT/GB2007/000934 2006-03-17 2007-03-16 Clinical correlates Ceased WO2007107714A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
PL07712923T PL2005182T3 (en) 2006-03-17 2007-03-16 Clinical correlates
AU2007228598A AU2007228598A1 (en) 2006-03-17 2007-03-16 Clinical correlates
ES07712923T ES2423479T3 (en) 2006-03-17 2007-03-16 Clinical correlates
DK07712923.7T DK2005182T3 (en) 2006-03-17 2007-03-16 Clinical correlates
US12/293,249 US8765366B2 (en) 2006-03-17 2007-03-16 Clinical correlates
JP2008558905A JP5258584B2 (en) 2006-03-17 2007-03-16 Clinical correlation
EP07712923.7A EP2005182B1 (en) 2006-03-17 2007-03-16 Clinical correlates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0605474.6 2006-03-17
GBGB0605474.6A GB0605474D0 (en) 2006-03-17 2006-03-17 Clinical correlates

Publications (3)

Publication Number Publication Date
WO2007107714A2 WO2007107714A2 (en) 2007-09-27
WO2007107714A3 true WO2007107714A3 (en) 2007-11-15
WO2007107714A8 WO2007107714A8 (en) 2009-07-16

Family

ID=36293021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000934 Ceased WO2007107714A2 (en) 2006-03-17 2007-03-16 Clinical correlates

Country Status (10)

Country Link
US (1) US8765366B2 (en)
EP (1) EP2005182B1 (en)
JP (1) JP5258584B2 (en)
AU (1) AU2007228598A1 (en)
DK (1) DK2005182T3 (en)
ES (1) ES2423479T3 (en)
GB (1) GB0605474D0 (en)
PL (1) PL2005182T3 (en)
PT (1) PT2005182E (en)
WO (1) WO2007107714A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1144447T3 (en) * 1998-11-04 2010-02-08 Isis Innovation Dianostic tuberculosis test
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
CN102033129A (en) * 2009-09-29 2011-04-27 上海英伯肯医学生物技术有限公司 Method for detecting pathogenic microorganism by using antigen-stimulated cellular immune response and test pen
SG184103A1 (en) * 2010-03-19 2012-10-30 Red Flag Diagnostics Gmbh In vitro process for the quick determination of a patient's status relating to infection with mycobacterium tuberculosis
CA2822419A1 (en) * 2010-12-23 2012-06-28 Giuseppe Pantaleo Methods for differentiating between disease states of mycobacterium tuberculosis infection
SG11201400629UA (en) 2011-09-13 2014-09-26 Sovicell Gmbh An in-vitro process for the quick determination of the infection status of an infection with an influenza virus type
GB201315748D0 (en) 2013-09-04 2013-10-16 Imp Innovations Ltd Biological methods and materials for use therein
US10684275B2 (en) 2016-12-14 2020-06-16 Becton, Dickinson And Company Methods and compositions for obtaining a tuberculosis assessment in a subject
EP4728275A1 (en) * 2023-06-19 2026-04-22 Immune Functional Diagnostics, LLC Methods and assays for immune phenotyping

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5750356A (en) 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
GB9624456D0 (en) * 1996-11-25 1997-01-15 Isis Innovation Assay method
NZ526807A (en) * 2001-01-08 2005-03-24 Isis Innovation Assay to determine efficacy of treatment for mycobacterial infection

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BOURGARIT ANNE ET AL: "Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients.", AIDS (LONDON, ENGLAND) 9 JAN 2006, vol. 20, no. 2, 9 January 2006 (2006-01-09), pages F1 - F7, XP002448595, ISSN: 0269-9370 *
DELGADO JULIO C ET AL: "Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 28 MAY 2002, vol. 99, no. 11, 28 May 2002 (2002-05-28), pages 7576 - 7581, XP002448596, ISSN: 0027-8424 *
EMU BRINDA ET AL: "Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment.", JOURNAL OF VIROLOGY NOV 2005, vol. 79, no. 22, November 2005 (2005-11-01), pages 14169 - 14178, XP002448592, ISSN: 0022-538X *
EWER K ET AL: "Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 361, no. 9364, 5 April 2003 (2003-04-05), pages 1168 - 1173, XP004784282, ISSN: 0140-6736 *
GUYOT-REVOL VALERIE ET AL: "Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 1 APR 2006, vol. 173, no. 7, 9 December 2005 (2005-12-09), pages 803 - 810, XP002448598, ISSN: 1073-449X *
HARARI ALEXANDRE ET AL: "Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 2005, vol. 174, no. 2, 15 January 2005 (2005-01-15), pages 1037 - 1045, XP002448593, ISSN: 0022-1767 *
MILLINGTON KERRY A ET AL: "Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 APR 2007, vol. 178, no. 8, 15 April 2007 (2007-04-15), pages 5217 - 5226, XP002448599, ISSN: 0022-1767 *
SEMMO NASSER ET AL: "Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.", HEPATOLOGY (BALTIMORE, MD.) MAY 2005, vol. 41, no. 5, May 2005 (2005-05-01), pages 1019 - 1028, XP002448594, ISSN: 0270-9139 *
TSUKAGUCHI K ET AL: "CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine production.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 FEB 1995, vol. 154, no. 4, 15 February 1995 (1995-02-15), pages 1786 - 1796, XP002448597, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
US20090170120A1 (en) 2009-07-02
PT2005182E (en) 2013-08-02
WO2007107714A2 (en) 2007-09-27
WO2007107714A8 (en) 2009-07-16
JP5258584B2 (en) 2013-08-07
JP2009529865A (en) 2009-08-27
US8765366B2 (en) 2014-07-01
AU2007228598A1 (en) 2007-09-27
DK2005182T3 (en) 2013-08-05
GB0605474D0 (en) 2006-04-26
ES2423479T3 (en) 2013-09-20
EP2005182B1 (en) 2013-05-01
PL2005182T3 (en) 2013-10-31
EP2005182A2 (en) 2008-12-24

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