WO2007109620A3 - Macrocyclic peptides and methods for making and using them - Google Patents

Macrocyclic peptides and methods for making and using them Download PDF

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Publication number
WO2007109620A3
WO2007109620A3 PCT/US2007/064317 US2007064317W WO2007109620A3 WO 2007109620 A3 WO2007109620 A3 WO 2007109620A3 US 2007064317 W US2007064317 W US 2007064317W WO 2007109620 A3 WO2007109620 A3 WO 2007109620A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
macrocyclic peptides
provides
making
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/064317
Other languages
French (fr)
Other versions
WO2007109620A2 (en
Inventor
Shelli R Mcalpine
Kathleen Mcguire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
San Diego State University Research Foundation
San Diego State University
Original Assignee
San Diego State University Research Foundation
San Diego State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by San Diego State University Research Foundation, San Diego State University filed Critical San Diego State University Research Foundation
Priority to EP07758829A priority Critical patent/EP2010203A2/en
Priority to US12/282,156 priority patent/US20090264345A1/en
Publication of WO2007109620A2 publication Critical patent/WO2007109620A2/en
Publication of WO2007109620A3 publication Critical patent/WO2007109620A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides novel macrocyclic peptides and methods for their preparation. The invention also provides pharmaceutical compositions and methods to treat, prevent or ameliorate a cell proliferative disease or conditions, e.g., a cancer, in a subject in need thereof, including but not limited to a colon cancer, such as MSS or MSI colon cancer, and pancreatic cancer. This invention provides for the synthesis and development of novel anticancer agents that are based on the core structure Sansalvamide A (San A).
PCT/US2007/064317 2006-03-17 2007-03-19 Macrocyclic peptides and methods for making and using them Ceased WO2007109620A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07758829A EP2010203A2 (en) 2006-03-17 2007-03-19 Macrocyclic peptides and methods for making and using them
US12/282,156 US20090264345A1 (en) 2006-03-17 2007-03-19 Macrocyclic peptides and methods for making and using them

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78329806P 2006-03-17 2006-03-17
US60/783,298 2006-03-17
US79711106P 2006-05-02 2006-05-02
US60/797,111 2006-05-02
US43637806A 2006-05-17 2006-05-17
US11/436,378 2006-05-17

Publications (2)

Publication Number Publication Date
WO2007109620A2 WO2007109620A2 (en) 2007-09-27
WO2007109620A3 true WO2007109620A3 (en) 2008-01-10

Family

ID=38523226

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064317 Ceased WO2007109620A2 (en) 2006-03-17 2007-03-19 Macrocyclic peptides and methods for making and using them

Country Status (2)

Country Link
EP (1) EP2010203A2 (en)
WO (1) WO2007109620A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044951A1 (en) * 2007-10-02 2009-04-08 Merz Pharma GmbH & Co. KGaA The use of substances for the treatment of loss of eyesight in humans with glaucoma and other degenerative eye diseases
JP2010053118A (en) * 2008-07-28 2010-03-11 Fujifilm Corp Biotinylated thyroxine
WO2012100176A2 (en) 2011-01-20 2012-07-26 University Of Rochester Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation
JP5804463B2 (en) 2012-12-27 2015-11-04 国立研究開発法人科学技術振興機構 Cyclic peptide and pharmaceutical containing the same
EP2752201A1 (en) * 2013-01-04 2014-07-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. C-terminal HSP90 inhibitors to treat pituitary adenomas
CN107674117B (en) * 2017-09-19 2021-03-05 李玉民 Preparation method of Cu-64 labeled Dimer-San A cyclic peptide derivative pancreatic cancer molecular probe
CN108250276B (en) * 2018-02-06 2022-02-01 李玉民 Preparation method of Cu-64-labeled Hsp90 inhibitor pancreatic cancer diagnosis and treatment integrated molecular probe

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114918A (en) * 1989-12-28 1992-05-19 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic cyclic pentapeptides
US20050159346A1 (en) * 2003-10-08 2005-07-21 Silverman Richard B. Cyclic peptide antitumor agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114918A (en) * 1989-12-28 1992-05-19 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic cyclic pentapeptides
US20050159346A1 (en) * 2003-10-08 2005-07-21 Silverman Richard B. Cyclic peptide antitumor agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YE ET AL.: "DEPBT as an efficient coupling reagent for amide bond formation with remarkable resistance to racemization", PROTEIN SCIENCE, vol. 80, 30 December 2004 (2004-12-30), pages 172 - 178 *

Also Published As

Publication number Publication date
EP2010203A2 (en) 2009-01-07
WO2007109620A2 (en) 2007-09-27

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