WO2007112757A3 - A process for concentration of a polypeptide - Google Patents

A process for concentration of a polypeptide Download PDF

Info

Publication number
WO2007112757A3
WO2007112757A3 PCT/DK2007/000177 DK2007000177W WO2007112757A3 WO 2007112757 A3 WO2007112757 A3 WO 2007112757A3 DK 2007000177 W DK2007000177 W DK 2007000177W WO 2007112757 A3 WO2007112757 A3 WO 2007112757A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
concentration
composition
mammals
concentrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2007/000177
Other languages
French (fr)
Other versions
WO2007112757A2 (en
Inventor
Stefan Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymenex AS
Original Assignee
Zymenex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP13167427.7A priority Critical patent/EP2628746B1/en
Priority to EP08166902.0A priority patent/EP2100898B1/en
Priority to JP2009503414A priority patent/JP2009532394A/en
Priority to AU2007234195A priority patent/AU2007234195B2/en
Priority to NZ568728A priority patent/NZ568728A/en
Priority to BRPI0709737-9A priority patent/BRPI0709737A2/en
Priority to PL08166902T priority patent/PL2100898T3/en
Priority to KR1020157023398A priority patent/KR20150103339A/en
Priority to KR1020147010563A priority patent/KR20140057678A/en
Priority to US12/295,848 priority patent/US20090246187A1/en
Priority to EP13167428.5A priority patent/EP2631242B1/en
Priority to MX2008012748A priority patent/MX2008012748A/en
Priority to NO20211305A priority patent/NO347673B1/en
Priority to CA2632528A priority patent/CA2632528C/en
Priority to EP07711305.8A priority patent/EP2004672B1/en
Priority to PL13167427T priority patent/PL2628746T3/en
Priority to KR1020087026971A priority patent/KR101504969B1/en
Application filed by Zymenex AS filed Critical Zymenex AS
Publication of WO2007112757A2 publication Critical patent/WO2007112757A2/en
Publication of WO2007112757A3 publication Critical patent/WO2007112757A3/en
Priority to NO20082510A priority patent/NO20082510L/en
Priority to ZA2008/05346A priority patent/ZA200805346B/en
Priority to IL194267A priority patent/IL194267A/en
Priority to AU2008229659A priority patent/AU2008229659B2/en
Anticipated expiration legal-status Critical
Priority to NO20084776A priority patent/NO346368B1/en
Priority to IL211905A priority patent/IL211905A0/en
Priority to US13/094,321 priority patent/US8809055B2/en
Priority to US14/321,642 priority patent/US20140314735A1/en
Priority to IL235982A priority patent/IL235982A0/en
Priority to IL241654A priority patent/IL241654B/en
Priority to US15/041,841 priority patent/US9713634B2/en
Priority to US15/473,460 priority patent/US20170202927A1/en
Priority to US15/585,916 priority patent/US20180289777A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01061—Hydroxymethylbilane synthase (2.5.1.61)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06001—Arylsulfatase (3.1.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01046—Galactosylceramidase (3.2.1.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06008—Cerebroside-sulfatase (3.1.6.8)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Water Supply & Treatment (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.
PCT/DK2007/000177 2006-04-04 2007-04-04 A process for concentration of a polypeptide Ceased WO2007112757A2 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
KR1020087026971A KR101504969B1 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
JP2009503414A JP2009532394A (en) 2006-04-04 2007-04-04 Method for concentrating polypeptides
AU2007234195A AU2007234195B2 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
NZ568728A NZ568728A (en) 2006-04-04 2007-04-04 A process for concentration of a aryl sulfatase A
BRPI0709737-9A BRPI0709737A2 (en) 2006-04-04 2007-04-04 process for concentrating a polypeptide
PL08166902T PL2100898T3 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
KR1020157023398A KR20150103339A (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
KR1020147010563A KR20140057678A (en) 2006-04-04 2007-04-04 Method of Enriching the Polypeptide
US12/295,848 US20090246187A1 (en) 2006-04-04 2007-04-04 Process for concentration of a polypeptide
EP13167428.5A EP2631242B1 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
MX2008012748A MX2008012748A (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide.
NO20211305A NO347673B1 (en) 2006-04-04 2007-04-04 A composition comprising concentrated polypeptide and use thereof.
CA2632528A CA2632528C (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
EP07711305.8A EP2004672B1 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
PL13167427T PL2628746T3 (en) 2006-04-04 2007-04-04 A process for the concentration of a polypeptide
EP13167427.7A EP2628746B1 (en) 2006-04-04 2007-04-04 A process for the concentration of a polypeptide
EP08166902.0A EP2100898B1 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide
NO20082510A NO20082510L (en) 2006-04-04 2008-05-30 A method for concentration of a polypeptide
ZA2008/05346A ZA200805346B (en) 2006-04-04 2008-06-19 A process for concentration of a polypeptide
IL194267A IL194267A (en) 2006-04-04 2008-09-22 Method of concentrating a composition comprising aryl sulfatase a and/or a functionally equivalent part or analogues thereof
AU2008229659A AU2008229659B2 (en) 2006-04-04 2008-09-26 A process for concentration of a polypeptide
NO20084776A NO346368B1 (en) 2006-04-04 2008-11-12 A method for the concentration of alpha-mannosidase.
IL211905A IL211905A0 (en) 2006-04-04 2011-03-24 A process for concentration of a polypeptide
US13/094,321 US8809055B2 (en) 2006-04-04 2011-04-26 Process for concentration of a polypeptide
US14/321,642 US20140314735A1 (en) 2006-04-04 2014-07-01 Process for concentration of a polypeptide
IL235982A IL235982A0 (en) 2006-04-04 2014-11-30 A process for concentration of a polypeptide
IL241654A IL241654B (en) 2006-04-04 2015-09-16 Compositions comprising recombinant arylsulfatase and uses thereof for the treatment of metachromatic leukodystrophy
US15/041,841 US9713634B2 (en) 2006-04-04 2016-02-11 Process for concentration of a polypeptide
US15/473,460 US20170202927A1 (en) 2006-04-04 2017-03-29 Process for concentration of a polypeptide
US15/585,916 US20180289777A1 (en) 2006-04-04 2017-05-03 Process for concentration of a polypeptide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200600488 2006-04-04
DKPA200600488 2006-04-04
DKPA200600922 2006-07-05
DKPA200600922 2006-07-05

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/295,848 A-371-Of-International US20090246187A1 (en) 2006-04-04 2007-04-04 Process for concentration of a polypeptide
US13/094,321 Division US8809055B2 (en) 2006-04-04 2011-04-26 Process for concentration of a polypeptide
US15/041,841 Division US9713634B2 (en) 2006-04-04 2016-02-11 Process for concentration of a polypeptide

Publications (2)

Publication Number Publication Date
WO2007112757A2 WO2007112757A2 (en) 2007-10-11
WO2007112757A3 true WO2007112757A3 (en) 2008-02-28

Family

ID=38472949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2007/000177 Ceased WO2007112757A2 (en) 2006-04-04 2007-04-04 A process for concentration of a polypeptide

Country Status (20)

Country Link
US (6) US20090246187A1 (en)
EP (4) EP2004672B1 (en)
JP (6) JP2009532394A (en)
KR (3) KR20140057678A (en)
CN (1) CN105233276A (en)
AU (2) AU2007234195B2 (en)
BR (1) BRPI0709737A2 (en)
CA (3) CA2644642C (en)
DK (1) DK2628746T3 (en)
ES (3) ES2928096T3 (en)
HU (1) HUE042402T2 (en)
IL (4) IL194267A (en)
MX (1) MX2008012748A (en)
NO (3) NO347673B1 (en)
NZ (7) NZ623123A (en)
PL (3) PL2631242T3 (en)
PT (1) PT2628746T (en)
SI (1) SI2628746T1 (en)
WO (1) WO2007112757A2 (en)
ZA (2) ZA200805346B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8536315B2 (en) 2004-01-30 2013-09-17 Shire Pharmaceuticals Ireland Limited Production and purification of recombinant arylsulftase
ES2928096T3 (en) * 2006-04-04 2022-11-15 Takeda Pharmaceuticals Co A process for the concentration of a polypeptide
DK2538968T3 (en) * 2010-02-24 2017-12-11 Chiesi Farm Spa PROCEDURE FOR THE PREPARATION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALFA MANNOSIDASE
RS62620B1 (en) 2010-06-25 2021-12-31 Shire Human Genetic Therapies Methods and compositions for cns delivery of arylsulfatase a
SMT201600385T1 (en) 2010-06-25 2017-03-08 Shire Human Genetic Therapies Cns delivery of therapeutic agents
NZ605873A (en) * 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of arylsulfatase a
NZ605874A (en) 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of heparan n-sulfatase
ES2625511T3 (en) 2011-07-08 2017-07-19 Shire Human Genetic Therapies, Inc. Methods for purification of arylsulfatase A
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
CN104854122B (en) * 2012-11-13 2021-10-08 意大利凯西制药公司 Purification of Recombinant Human Galactocerebroside-β-Galactosidase (rhGALC)
AU2013357812B2 (en) * 2012-12-11 2019-10-10 Centogene Gmbh Method for the diagnosis of metachromatic leukodystrophy
AU2014205441B2 (en) 2013-01-09 2019-12-12 Takeda Pharmaceutical Company Limited Methods for purification of arylsulfatase A
AR095527A1 (en) 2013-03-15 2015-10-21 Biogen Idec Inc FC-FACTOR IX POLYPEPTIDE FORMULATIONS IX
EA202092926A3 (en) 2014-03-24 2021-10-29 Биовератив Терапьютикс Инк. LYOPHILIZED COMPOSITIONS CONTAINING FACTOR IX
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
KR102290596B1 (en) 2020-09-10 2021-08-19 주식회사 파이안바이오테크놀로지 Composition for injection comprising isolated mitochondria and use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
WO2000067789A1 (en) * 1999-05-10 2000-11-16 Csl Limited High concentration immunoglobulin preparation and method for its production
WO2001007065A2 (en) * 1999-07-27 2001-02-01 Hemebiotech A/S PRODUCTION OF rhPBGD AND NEW THERAPEUTIC METHODS FOR TREATING PATIENTS WITH ACUTE INTERMITTENT PORPHYRIA (AIP) AND OTHER PORPHYRIC DISEASES
WO2002098455A2 (en) * 2001-06-07 2002-12-12 Hemebiotech A/S Production of recombinant human arylsulfatase a
WO2003066669A2 (en) * 2002-02-04 2003-08-14 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
WO2005073367A1 (en) * 2004-01-30 2005-08-11 Zymenex A/S Production and purification of recombinant arylsulfatase a

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2041280A1 (en) 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
NO960163D0 (en) 1996-01-15 1996-01-15 Thomas Berg Mutational detection of bovine
AU750143B2 (en) 1998-01-27 2002-07-11 Zymenex A/S Method for treating acute intermittent porphyria (AIP) and other porphyric diseases
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
US6537777B1 (en) 1998-07-27 2003-03-25 Hemebiotech A/S Human porphobilinogen deaminase sequences
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
CA2429210A1 (en) 2000-11-15 2002-05-23 Jason C. Goodrick Expression system for recombinant proteins
AU2002317701A1 (en) * 2001-06-07 2002-12-16 Hemebiotech A/S Production of recombinant human lysosomal alpha-mannosidase
EP1402014A1 (en) 2001-06-29 2004-03-31 Hemebiotech A/S A process for purification of recombinant porphobilinogen deaminase
US7232670B2 (en) * 2001-09-28 2007-06-19 St. Jude Children's Research Hospital Targeting proteins to cells expressing mannose receptors via expression in insect cells
AU2003222568B2 (en) 2002-01-11 2009-05-07 Bioasis Technologies, Inc. Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
CH694697A5 (en) 2004-01-29 2005-06-15 Koelbl Engineering Und Consult Thermoplastic elastomer-like elastomer alloy, useful for preparing articles by e.g. injection molding, comprises thermoplast, powdered rubber and a dispersant or emulsifier
SI1740204T1 (en) 2004-04-01 2018-07-31 Chiesi Farmaceutici S.P.A. Medicinal use of alpha-mannosidase
US20060051347A1 (en) * 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
ES2928096T3 (en) * 2006-04-04 2022-11-15 Takeda Pharmaceuticals Co A process for the concentration of a polypeptide

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
WO2000067789A1 (en) * 1999-05-10 2000-11-16 Csl Limited High concentration immunoglobulin preparation and method for its production
WO2001007065A2 (en) * 1999-07-27 2001-02-01 Hemebiotech A/S PRODUCTION OF rhPBGD AND NEW THERAPEUTIC METHODS FOR TREATING PATIENTS WITH ACUTE INTERMITTENT PORPHYRIA (AIP) AND OTHER PORPHYRIC DISEASES
WO2002098455A2 (en) * 2001-06-07 2002-12-12 Hemebiotech A/S Production of recombinant human arylsulfatase a
WO2003066669A2 (en) * 2002-02-04 2003-08-14 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
WO2005073367A1 (en) * 2004-01-30 2005-08-11 Zymenex A/S Production and purification of recombinant arylsulfatase a

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
POHL T: "CONCENTRATION OF PROTEINS AND REMOVAL OF SOLUTES", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 182, 1990, pages 68 - 83, XP009052406, ISSN: 0076-6879 *
SEVIN CAROLINE ET AL: "Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy.", HUMAN MOLECULAR GENETICS 1 JAN 2006, vol. 15, no. 1, 1 January 2006 (2006-01-01), pages 53 - 64, XP002463697, ISSN: 0964-6906 *
STEVENS R L ET AL: "PURIFICATION AND PROPERTIES OF ARYL SULFATASE A FROM HUMAN URINE", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 250, no. 7, 1975, pages 2495 - 2501, XP002300885, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2632528A1 (en) 2007-10-11
EP2628746A3 (en) 2014-03-19
HUE042402T2 (en) 2019-06-28
NZ571610A (en) 2011-07-29
PT2628746T (en) 2019-04-23
NZ588903A (en) 2012-08-31
IL211905A0 (en) 2011-05-31
ES2744499T3 (en) 2020-02-25
EP2631242A3 (en) 2013-10-02
NO20084776L (en) 2008-10-31
PL2100898T3 (en) 2019-11-29
KR101504969B1 (en) 2015-03-24
AU2007234195A1 (en) 2007-10-11
IL194267A0 (en) 2011-08-01
CA2882501C (en) 2021-09-07
DK2628746T3 (en) 2019-04-01
CN105233276A (en) 2016-01-13
JP2013236633A (en) 2013-11-28
EP2628746B1 (en) 2019-01-09
NZ623123A (en) 2015-04-24
JP2014051503A (en) 2014-03-20
NZ582045A (en) 2011-07-29
MX2008012748A (en) 2009-01-07
US8809055B2 (en) 2014-08-19
US20090246187A1 (en) 2009-10-01
US20140314735A1 (en) 2014-10-23
EP2631242B1 (en) 2022-08-03
PL2631242T3 (en) 2023-03-20
NO20082510L (en) 2008-10-31
EP2100898B1 (en) 2019-06-19
AU2007234195B2 (en) 2013-02-07
CA2644642A1 (en) 2007-10-11
BRPI0709737A2 (en) 2011-07-26
EP2628746A2 (en) 2013-08-21
NZ568728A (en) 2011-09-30
NZ607595A (en) 2014-10-31
JP2009532394A (en) 2009-09-10
US20160193304A1 (en) 2016-07-07
NO20211305A1 (en) 2008-10-31
AU2008229659B2 (en) 2013-01-31
NZ597548A (en) 2013-08-30
PL2628746T3 (en) 2019-07-31
CA2644642C (en) 2016-01-26
JP2014058521A (en) 2014-04-03
IL241654B (en) 2019-02-28
IL194267A (en) 2015-10-29
NO346368B1 (en) 2022-06-27
KR20150103339A (en) 2015-09-09
NO347673B1 (en) 2024-02-19
JP5878152B2 (en) 2016-03-08
ES2928096T3 (en) 2022-11-15
JP2016104000A (en) 2016-06-09
SI2628746T1 (en) 2019-04-30
JP5384232B2 (en) 2014-01-08
US20170202927A1 (en) 2017-07-20
IL241654A0 (en) 2015-11-30
EP2004672A2 (en) 2008-12-24
EP2004672B1 (en) 2015-08-19
US20180289777A1 (en) 2018-10-11
KR20140057678A (en) 2014-05-13
KR20090018894A (en) 2009-02-24
US9713634B2 (en) 2017-07-25
AU2008229659A1 (en) 2008-10-23
EP2100898A1 (en) 2009-09-16
EP2631242A2 (en) 2013-08-28
CA2882501A1 (en) 2007-10-11
IL235982A0 (en) 2015-01-29
WO2007112757A2 (en) 2007-10-11
ZA200805346B (en) 2018-11-28
US20120076767A1 (en) 2012-03-29
JP2009273469A (en) 2009-11-26
ZA200809540B (en) 2019-09-25
CA2632528C (en) 2022-07-12
ES2713488T3 (en) 2019-05-22

Similar Documents

Publication Publication Date Title
WO2007112757A3 (en) A process for concentration of a polypeptide
AU2008301614A8 (en) Mutant pyrrolysyl-tRNA synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same
WO2006093348A3 (en) Method and composition for treating peripheral vascular diseases
WO2008063842A3 (en) Methods of treating neuropathic pain with agonists of ppar-gamma
WO2007024705A3 (en) Method of treating depression using a tnf-alpha antibody
WO2009098682A3 (en) Methods and compositions for treatment of mitochondrial disorders
WO2009149171A3 (en) Fgf21 mutants and uses thereof
WO2010129600A3 (en) Fgf21 mutants and uses thereof
WO2006104913A3 (en) USE OF ANTI-TNF OR ANTI-ILl RNAI TO SUPPRESS PRO- INFLAMMATORY CYTOKINE ACTIONS LOCALLY TO TREAT PAIN
UA107329C2 (en) Tuberculous protein rv2386c, a composition containing the one, and applications
WO2010082804A3 (en) Method for producing physiologically active protein or peptide using immunoglobulin fragment
WO2008066558A3 (en) Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
WO2010127172A3 (en) Chimeric factor h binding proteins (fhbp) and methods of use
WO2007143086A3 (en) Delivery method
WO2010025321A3 (en) Method for treating multiple sclerosis patients with anti-il2r antibodies
WO2007001264A3 (en) Method of making recombinant human antibodies for use in biosensor technology
WO2007025977A8 (en) Anti-tnf alpha producing lactic acid bacteria for the treatment of chronic enterocolitis
NZ601142A (en) Composition for improving brain function and method for improving brain function
WO2011075606A3 (en) Hyperglycosylated polypeptide variants and methods of use
WO2006101387A3 (en) Method for interfering with blood coagulation by modulating cross-beta structures fibril formation
WO2009107971A3 (en) Polypeptide specifically coupled to phosphatidylserine and use thereof
WO2007106792A3 (en) Methods for treating sarcopenia with a growth hormone secretagogue
WO2008033556A3 (en) High pressure treatment of proteins for reduced immunogenicity
WO2009138494A3 (en) Amino acid sequences directed against toll-like receptors and their use for the treatment of diseases related to toll-like receptors
WO2009082028A3 (en) Process for producing (2s,3r,4s)-4-hydroxy-l-isoleucine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07711305

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2632528

Country of ref document: CA

Ref document number: 568728

Country of ref document: NZ

Ref document number: 2007711305

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2009503414

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2007234195

Country of ref document: AU

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2007234195

Country of ref document: AU

Date of ref document: 20070404

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2007234195

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 194267

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 200780011523.4

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 12295848

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: MX/A/2008/012748

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1020087026971

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0709737

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20081003

WWE Wipo information: entry into national phase

Ref document number: 1020147010563

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 235982

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 241654

Country of ref document: IL