WO2007115694A3 - Miniaturised biosensor with optimized amperometric detection - Google Patents

Miniaturised biosensor with optimized amperometric detection Download PDF

Info

Publication number
WO2007115694A3
WO2007115694A3 PCT/EP2007/002793 EP2007002793W WO2007115694A3 WO 2007115694 A3 WO2007115694 A3 WO 2007115694A3 EP 2007002793 W EP2007002793 W EP 2007002793W WO 2007115694 A3 WO2007115694 A3 WO 2007115694A3
Authority
WO
WIPO (PCT)
Prior art keywords
microchannel
detection
amperometric
miniaturised
biosensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/002793
Other languages
French (fr)
Other versions
WO2007115694A2 (en
Inventor
Frederic Reymond
Joel Stephane Rossier
Patrick Morier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DiagnoSwiss SA
Biomerieux SA
Original Assignee
DiagnoSwiss SA
Biomerieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DiagnoSwiss SA, Biomerieux SA filed Critical DiagnoSwiss SA
Priority to US12/296,639 priority Critical patent/US20090178935A1/en
Priority to JP2009504600A priority patent/JP2009533658A/en
Priority to EP07723737A priority patent/EP2005156A2/en
Publication of WO2007115694A2 publication Critical patent/WO2007115694A2/en
Publication of WO2007115694A3 publication Critical patent/WO2007115694A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A method to optimize the amperometric detection in a microsystem consists in limiting the detection to times when the diffusion layer (18-20) of the analyte to detect remains smaller than the microchannel (7) height. The charge detected during the second part of the amperometric measurement (which corresponds to the integral of the measured current over the corresponding time period) can also be considered so as to remove the contribution of the capacitive current and, when applicable, of the current resulting from the reduction or oxidation of the analyte molecules present in a recess above the electrode at the beginning of the detection. A microfluidic amperometric sensor for performing the method comprises at least one microchannel (7) having at least one electrode (15-17), integrated in one wall of the microchannel, and having a characteristic length or radius which is smaller than half the microchannel height.
PCT/EP2007/002793 2006-04-10 2007-03-29 Miniaturised biosensor with optimized amperometric detection Ceased WO2007115694A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/296,639 US20090178935A1 (en) 2006-04-10 2007-03-29 Miniaturised Biosensor with Optimized Amperometric Detection
JP2009504600A JP2009533658A (en) 2006-04-10 2007-03-29 Compact biosensor with optimized amperometric detection
EP07723737A EP2005156A2 (en) 2006-04-10 2007-03-29 Miniaturised biosensor with optimized amperometric detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0607205.2A GB0607205D0 (en) 2006-04-10 2006-04-10 Miniaturised biosensor with optimized anperimetric detection
GB0607205.2 2006-04-10

Publications (2)

Publication Number Publication Date
WO2007115694A2 WO2007115694A2 (en) 2007-10-18
WO2007115694A3 true WO2007115694A3 (en) 2008-02-28

Family

ID=36539685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/002793 Ceased WO2007115694A2 (en) 2006-04-10 2007-03-29 Miniaturised biosensor with optimized amperometric detection

Country Status (6)

Country Link
US (1) US20090178935A1 (en)
EP (1) EP2005156A2 (en)
JP (1) JP2009533658A (en)
CN (1) CN101421616A (en)
GB (1) GB0607205D0 (en)
WO (1) WO2007115694A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010003205A (en) * 2007-09-24 2010-04-09 Bayer Healthcare Llc Multi-electrode test sensors.
US8359083B2 (en) 2008-04-02 2013-01-22 University Of Utah Research Foundation Microelectrode array system with integrated reference microelectrodes to reduce detected electrical noise and improve selectivity of activation
US8639312B2 (en) 2008-12-10 2014-01-28 University Of Utah Research Foundation System and method for electrically shielding a microelectrode array in a physiological pathway from electrical noise
US8760178B2 (en) 2009-09-30 2014-06-24 Arkray, Inc. Method for measuring target component in erythrocyte-containing specimen
JP5350960B2 (en) * 2009-09-30 2013-11-27 アークレイ株式会社 Method for measuring target components in erythrocyte-containing samples
FR2952800B1 (en) * 2009-11-25 2012-02-03 Fabre Pierre Dermo Cosmetique ELECTROCHEMICAL DEVICE FOR DETERMINING ANTIOXIDANT PROPERTIES OF THE SKIN
US20110139636A1 (en) * 2009-12-14 2011-06-16 Lai Rebecca Y Gold-plated screen-printed electrodes and their use as electrochemical sensors
ES2367615B1 (en) * 2009-12-15 2013-01-22 Consejo Superior De Investigaciones Científicas (Csic) MULTIANALYTIC SYSTEM AND PROCEDURE BASED ON IMPEDIMETRIC MEASUREMENTS.
KR101719390B1 (en) * 2009-12-31 2017-03-23 테크놀로지안 투트키무스케스쿠스 브이티티 오와이 Electronic fluidic indicator and method of indicating
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
US20120052188A1 (en) 2010-02-08 2012-03-01 Genia Technologies, Inc. Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
DE102010002915B4 (en) * 2010-03-16 2012-10-18 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Microfluidic sensor
US8715558B2 (en) 2010-05-03 2014-05-06 Indian Institute Of Technology Bombay Capillary electrophoresis chips
US8940141B2 (en) 2010-05-19 2015-01-27 Lifescan Scotland Limited Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution
US8600513B2 (en) * 2010-12-09 2013-12-03 The Board Of Trustees Of The Leland Stanford Junior University Seizure prediction and neurological disorder treatment
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
JP6435264B2 (en) 2013-08-07 2018-12-05 アークレイ株式会社 Method and apparatus for measuring substances using electrochemical biosensor
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
ZA201607865B (en) * 2015-11-18 2019-10-30 Univ Stellenbosch A device for detecting target biomolecules
JP7109785B2 (en) 2016-01-14 2022-08-01 ロズウェル バイオテクノロジーズ，インコーポレイテッド Molecular sensors and related methods
US10712334B2 (en) 2016-01-28 2020-07-14 Roswell Biotechnologies, Inc. Massively parallel DNA sequencing apparatus
EP3408220A4 (en) 2016-01-28 2019-09-04 Roswell Biotechnologies, Inc METHOD AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE MOLECULAR ELECTRONIC ELECTRONIC SENSOR ARRAYS
CN105548315A (en) * 2016-02-02 2016-05-04 苏州甫一电子科技有限公司 Polymer micro-fluidic chip and preparation method thereof
US10737263B2 (en) 2016-02-09 2020-08-11 Roswell Biotechnologies, Inc. Electronic label-free DNA and genome sequencing
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
US10983088B2 (en) * 2016-03-28 2021-04-20 University Of Massachusetts Coulometric microfluidic sensors using a silver band electrode, and methods thereof
JP6924556B2 (en) * 2016-04-12 2021-08-25 株式会社日立プラントサービス Microreactor, chemical product manufacturing system and microreactor manufacturing method
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
CN107870188B (en) * 2016-09-23 2020-07-14 南京大学 Detection kit and preparation method thereof, analysis system comprising the detection kit, and use thereof
JP6920642B2 (en) * 2016-12-07 2021-08-18 パナソニックＩｐマネジメント株式会社 Electrochemical measuring method and electrochemical measuring device
CN110431148A (en) 2017-01-10 2019-11-08 罗斯威尔生命技术公司 Method and system for DNA data storage
KR102685937B1 (en) 2017-01-19 2024-07-17 로스웰 엠이 아이엔씨. Solid state sequencing devices comprising two dimensional layer materials
KR102692957B1 (en) 2017-04-25 2024-08-06 로스웰 엠이 아이엔씨. Enzyme circuits for molecular sensors
CN110651182B (en) 2017-05-09 2022-12-30 罗斯威尔生命技术公司 Bonded probe circuit for molecular sensors
CN107144613B (en) * 2017-05-09 2019-01-18 中国石油大学(华东) Three electrod-array Local electrochemical information test macros and test method
EP3676389A4 (en) 2017-08-30 2021-06-02 Roswell Biotechnologies, Inc ELECTRONIC MOLECULAR PROCESSIVE ENZYME SENSORS FOR DNA DATA STORAGE
WO2019075100A1 (en) 2017-10-10 2019-04-18 Roswell Biotechnologies, Inc. Methods, apparatus and systems for amplification-free dna data storage
US11284816B2 (en) * 2018-02-13 2022-03-29 PercuSense, Inc. Multi-analyte continuous glucose monitoring
EP3569716A1 (en) * 2018-05-14 2019-11-20 Consejo Superior De Investigaciones Científicas (CSIC) A method for controlling timing of events in a microfluidic device and a timer microfluidic device
US12504396B2 (en) 2019-04-12 2025-12-23 SemiconBio Polycyclic aromatic bridges for molecular electronic sensors
KR102532761B1 (en) * 2019-08-02 2023-05-16 바이오나임 코포레이션 Method for Reducing Measurement Interference of Micro Biosensor
WO2021045900A1 (en) 2019-09-06 2021-03-11 Roswell Biotechnologies, Inc. Methods of fabricating nanoscale structures usable in molecular sensors and other devices
CN114965653B (en) * 2022-06-10 2024-02-23 江苏好上医生物医药有限公司 Double-cabin photoelectrochemical sensing system for detecting prothrombin time and detection method
CN118614914A (en) * 2024-08-15 2024-09-10 南开大学 A wearable sweat sensor for real-time sports health monitoring

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1236995A1 (en) * 1995-11-16 2002-09-04 USF Filtration and Separations Group Inc. Repetitive potential step method for amperometric detection
WO2005026665A2 (en) * 2003-09-15 2005-03-24 Diagnoswiss S.A. Microfluidic flow monitoring device

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0718839B2 (en) * 1983-03-04 1995-03-06 イーエスエイ，インコーポレイレッド Method and device for electrochemical analysis of biochemical samples such as body fluids
JPH0675059B2 (en) * 1983-06-03 1994-09-21 株式会社柳本製作所 Micro High-Performance Liquid Chromatographic Analysis Method Using Dual-Acting Electrochemical Detector
US6174420B1 (en) * 1996-11-15 2001-01-16 Usf Filtration And Separations Group, Inc. Electrochemical cell
US6616819B1 (en) * 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
GB0010957D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Compound & method
US6444115B1 (en) * 2000-07-14 2002-09-03 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
GB0103516D0 (en) * 2001-02-13 2001-03-28 Cole Polytechnique Federale De Apparatus for dispensing a sample
US7037417B2 (en) * 2001-03-19 2006-05-02 Ecole Polytechnique Federale De Lausanne Mechanical control of fluids in micro-analytical devices
GB0111438D0 (en) * 2001-05-10 2001-07-04 Cole Polytechnique Federale De Polymer bonding by means of plasma activation
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
GB0121189D0 (en) * 2001-08-31 2001-10-24 Diagnoswiss Sa Apparatus and method for separating an analyte
GB0226160D0 (en) * 2002-11-08 2002-12-18 Diagnoswiss Sa Apparatus for dispensing a sample in electrospray mass spectrometers
GB0300820D0 (en) * 2003-01-14 2003-02-12 Diagnoswiss Sa Membrane-microchannel strip
GB0306163D0 (en) * 2003-03-18 2003-04-23 Univ Cambridge Tech Embossing microfluidic sensors
JP3838435B2 (en) * 2003-06-25 2006-10-25 明胤 秋山 Hypochlorous acid concentration measuring device
JP2005031049A (en) * 2003-07-11 2005-02-03 Sekisui Chem Co Ltd Analytical microreactor
JP2006026214A (en) * 2004-07-20 2006-02-02 Fado:Kk Air sterilizing and washing machine
CN101057136A (en) * 2004-11-12 2007-10-17 迪埃诺斯维斯股份有限公司 Microfluidic devices with minimized ohmic resistance

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1236995A1 (en) * 1995-11-16 2002-09-04 USF Filtration and Separations Group Inc. Repetitive potential step method for amperometric detection
WO2005026665A2 (en) * 2003-09-15 2005-03-24 Diagnoswiss S.A. Microfluidic flow monitoring device

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BLAEDEL WALTER J ET AL: "SURFACE VOLTAMMETRY AND SURFACE COULOMETRY AT SOLID ELECTRODES", ANAL CHEM DEC 1981, vol. 53, no. 14, December 1981 (1981-12-01), pages 2270 - 2274, XP002453352 *
GUNASINGHAM HARI ET AL: "Pulsed amperometric detection of glucose using a mediated enzyme electrode", JOURNAL OF ELECTROANALYTICAL CHEMISTRY AND INTERFACIAL ELECTROCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 287, no. 2, 25 July 1990 (1990-07-25), pages 349 - 362, XP002328306, ISSN: 0022-0728 *
ROSSIER J ET AL: "POLYMER MICROFLUIDIC CHIPS FOR ELECTROCHEMICAL AND BIOCHEMICAL ANALYSES", ELECTROPHORESIS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 23, no. 6, March 2002 (2002-03-01), pages 858 - 867, XP001080091, ISSN: 0173-0835 *
ROSSIER J S ET AL: "ENZYME LINKED IMMUNOSORBENT ASSAY ON A MICROCHIP WITH ELECTROCHEMICAL DETECTION", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 1, no. 2, December 2001 (2001-12-01), pages 153 - 157, XP009030699, ISSN: 1473-0197 *
ROSSIER J S ET AL: "PLASMA ETCHED POLYMER MICROELECTROCHEMICAL SYSTEMS", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 2, no. 3, 17 July 2002 (2002-07-17), pages 145 - 150, XP009030711, ISSN: 1473-0197 *
STEEL A B ET AL: "Electrochemical Quantitation of DNA immobilized on Gold", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 70, no. 22, 15 November 1998 (1998-11-15), pages 4670 - 4677, XP002285670, ISSN: 0003-2700 *
TAKATSY ET AL: "Periodically interrupted amperometry at membrane coated electrodes: A simplified pulsed amperometry", TALANTA, ELSEVIER, AMSTERDAM, NL, vol. 69, no. 1, 15 March 2006 (2006-03-15), pages 281 - 285, XP005272182, ISSN: 0039-9140 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors

Also Published As

Publication number Publication date
GB0607205D0 (en) 2006-05-17
CN101421616A (en) 2009-04-29
EP2005156A2 (en) 2008-12-24
WO2007115694A2 (en) 2007-10-18
JP2009533658A (en) 2009-09-17
US20090178935A1 (en) 2009-07-16

Similar Documents

Publication Publication Date Title
EP2484781A3 (en) Detection of analytes and nucleic acids
WO2006066274A3 (en) Breath-based sensors for non-invasive molecular detection
WO2008135862A3 (en) Devices and methods for detecting analytes
IL255222A0 (en) Process for detecting qualitatively or quantitatively the presence of a single-stranded or double-stranded nucleic acid analyte in a sample
JP2009536744A5 (en)
WO2008051742A3 (en) Transient decay amperometry
EP2851676A3 (en) Method and assembly for determining the temperature of a test sensor
WO2006083269A3 (en) Luminescent nanosensors
WO2007133457A3 (en) Electrochemical test sensor with reduced sample volume
WO2005106036A3 (en) Methods and compositions for assaying analytes
WO2007133985A3 (en) Abnormal output detection system for a biosensor
WO2010028140A3 (en) Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
WO2007121111A3 (en) System and methods for providing corrected analyte concentration measurements
AU2002366046A1 (en) Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
CA2568824A1 (en) Glucose biosensor and method
WO2007084516A3 (en) Membranes for an analyte sensor
EP2584044A3 (en) Electrochemical analyte detections apparatus and method
CY1113686T1 (en) BIO-SENSOR DEVICE AND ITS METHODS OF USE
JP2009536734A5 (en)
WO2008137466A3 (en) Nucleic acid quantitation methods
WO2009122159A3 (en) Biosensor for analyte detection
WO2011008030A3 (en) Chromatographic system for nucleic acid detection
ATE532063T1 (en) ELECTROCHEMICAL BIOSENSOR
WO2007001402A3 (en) Redox potential mediated, heterogeneous, carbon nanotube biosensing
WO2005080602A3 (en) Immunological detection of rna:dna hybrids on microarrays

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07723737

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009504600

Country of ref document: JP

Ref document number: 12296639

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 200780012898.2

Country of ref document: CN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007723737

Country of ref document: EP