WO2007118704A3 - Methods and nucleic acids for the detection of colorectal cell proliferative disorders - Google Patents

Methods and nucleic acids for the detection of colorectal cell proliferative disorders Download PDF

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Publication number
WO2007118704A3
WO2007118704A3 PCT/EP2007/003380 EP2007003380W WO2007118704A3 WO 2007118704 A3 WO2007118704 A3 WO 2007118704A3 EP 2007003380 W EP2007003380 W EP 2007003380W WO 2007118704 A3 WO2007118704 A3 WO 2007118704A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
cell proliferative
detection
proliferative disorders
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/003380
Other languages
French (fr)
Other versions
WO2007118704A2 (en
Inventor
Catherine Lofton-Day
Matthias Ebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/014131 external-priority patent/WO2006113466A2/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Priority to JP2009505769A priority Critical patent/JP5323680B2/en
Priority to AU2007237444A priority patent/AU2007237444B2/en
Priority to CA2649777A priority patent/CA2649777C/en
Priority to US12/297,303 priority patent/US20090317810A1/en
Priority to EP07724317A priority patent/EP2013360A2/en
Publication of WO2007118704A2 publication Critical patent/WO2007118704A2/en
Publication of WO2007118704A3 publication Critical patent/WO2007118704A3/en
Anticipated expiration legal-status Critical
Priority to US17/590,200 priority patent/US20220260570A1/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides methods, nucleic acids and kits for detecting, or for distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
PCT/EP2007/003380 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders Ceased WO2007118704A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2009505769A JP5323680B2 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for detecting colorectal cell proliferative diseases
AU2007237444A AU2007237444B2 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders
CA2649777A CA2649777C (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US12/297,303 US20090317810A1 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders
EP07724317A EP2013360A2 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US17/590,200 US20220260570A1 (en) 2006-04-17 2022-02-01 Methods and nucleic acids for the detection of colorectal cell proliferative disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2006/014131 WO2006113466A2 (en) 2005-04-15 2006-04-17 Methods and nucleic acids for analyses of cellular proliferative disorders
USPCT/US2006/014131 2006-04-17
EP06090119.6 2006-06-27
EP06090119 2006-06-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/014131 Continuation-In-Part WO2006113466A2 (en) 2005-04-15 2006-04-17 Methods and nucleic acids for analyses of cellular proliferative disorders

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/297,303 A-371-Of-International US20090317810A1 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US17/590,200 Continuation US20220260570A1 (en) 2006-04-17 2022-02-01 Methods and nucleic acids for the detection of colorectal cell proliferative disorders

Publications (2)

Publication Number Publication Date
WO2007118704A2 WO2007118704A2 (en) 2007-10-25
WO2007118704A3 true WO2007118704A3 (en) 2008-04-24

Family

ID=40030469

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/003380 Ceased WO2007118704A2 (en) 2006-04-17 2007-04-17 Methods and nucleic acids for the detection of colorectal cell proliferative disorders

Country Status (7)

Country Link
US (1) US20220260570A1 (en)
EP (3) EP2484778A3 (en)
JP (2) JP5323680B2 (en)
AU (1) AU2007237444B2 (en)
CA (1) CA2649777C (en)
ES (1) ES2587068T3 (en)
WO (1) WO2007118704A2 (en)

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KR20130021400A (en) 2005-04-15 2013-03-05 에피제노믹스 아게 Methods and nucleic acids for analyses of cellular proliferative disorders
WO2008122447A2 (en) * 2007-04-10 2008-10-16 Epigenomics Ag Dna methylation assay for the diagnosis or prognosis of medical conditions
BR112013005929B1 (en) * 2010-09-13 2021-02-09 Clinical Genomics Pty. Ltd. methods of screening for onset or predisposition to onset of large intestine neoplasm or monitoring of neoplasm progress in an individual
FR2967165B1 (en) * 2010-11-04 2014-10-10 Assist Publ Hopitaux De Paris METHOD OF SCREENING COLORECTAL CANCER
WO2013007702A1 (en) 2011-07-08 2013-01-17 Epigenomics Ag Methods and nucleic acids for determining the prognosis of a cancer subject
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
CN104046680B (en) * 2013-03-11 2016-04-06 苏州承美生物科技有限公司 Methylate DNA detection method
JP6722659B2 (en) * 2014-06-04 2020-07-15 クエスト ダイアグノスティクス インベストメンツ インコーポレイテッド Methylation markers for colorectal cancer
KR20190054086A (en) * 2016-09-29 2019-05-21 이에이 파마 가부시키가이샤 How to determine the likelihood of developing a high grade colorectal cancer
WO2018087129A1 (en) * 2016-11-08 2018-05-17 Region Nordjylland, Aalborg University Hospital Colorectal cancer methylation markers
EP3660172A1 (en) * 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Method for detection of traumatic brain injury (tbi)
CN111826441A (en) * 2019-04-23 2020-10-27 博尔诚（北京）科技有限公司 System for in vitro detection of five cancers of the digestive tract, composition for use in such a system, and kit comprising such a composition
CN112195243A (en) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 Kit for detecting polygene methylation and application thereof

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Also Published As

Publication number Publication date
AU2007237444A1 (en) 2007-10-25
JP5323680B2 (en) 2013-10-23
ES2587068T3 (en) 2016-10-20
EP2479283B1 (en) 2016-06-22
US20220260570A1 (en) 2022-08-18
JP5846693B2 (en) 2016-01-20
CA2649777A1 (en) 2007-10-25
JP2013230153A (en) 2013-11-14
AU2007237444B2 (en) 2013-05-23
WO2007118704A2 (en) 2007-10-25
JP2009533066A (en) 2009-09-17
EP2484778A2 (en) 2012-08-08
EP2484778A3 (en) 2012-10-10
EP2013360A2 (en) 2009-01-14
EP2479283A1 (en) 2012-07-25
CA2649777C (en) 2018-08-14

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