WO2007118832A3 - Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders - Google Patents

Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders Download PDF

Info

Publication number
WO2007118832A3
WO2007118832A3 PCT/EP2007/053524 EP2007053524W WO2007118832A3 WO 2007118832 A3 WO2007118832 A3 WO 2007118832A3 EP 2007053524 W EP2007053524 W EP 2007053524W WO 2007118832 A3 WO2007118832 A3 WO 2007118832A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicaments
cardiovascular disorders
compounds
androstenes
androstanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/053524
Other languages
French (fr)
Other versions
WO2007118832A2 (en
Inventor
Alberto Cerri
Marco Torri
Silvia Armaroli
Leonardo Banfi
Giuseppe Bianchi
Giulio Carzana
Patrizia Ferrari
Rosamaria Micheletti
Simona Sputore
Maria Pia Zappavigna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to ES07727992T priority Critical patent/ES2405625T3/en
Priority to MX2008012942A priority patent/MX2008012942A/en
Priority to PL07727992T priority patent/PL2004668T3/en
Priority to KR1020087027712A priority patent/KR101424046B1/en
Priority to CN200780022229.3A priority patent/CN101466725B/en
Priority to US12/295,497 priority patent/US8609644B2/en
Priority to EA200870434A priority patent/EA015257B1/en
Priority to HK09111966.8A priority patent/HK1134821B/en
Priority to JP2009504741A priority patent/JP5438503B2/en
Priority to BRPI0709943-6A priority patent/BRPI0709943A2/en
Priority to EP07727992A priority patent/EP2004668B1/en
Priority to CA2649175A priority patent/CA2649175C/en
Priority to AU2007239518A priority patent/AU2007239518B2/en
Publication of WO2007118832A2 publication Critical patent/WO2007118832A2/en
Publication of WO2007118832A3 publication Critical patent/WO2007118832A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. Said compounds are used for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
PCT/EP2007/053524 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders Ceased WO2007118832A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES07727992T ES2405625T3 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenosis as medications for cardiovascular disorders
MX2008012942A MX2008012942A (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders.
PL07727992T PL2004668T3 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
KR1020087027712A KR101424046B1 (en) 2006-04-13 2007-04-11 Amino derivatives of androstane and androstene as drugs for cardiovascular disorders
CN200780022229.3A CN101466725B (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
US12/295,497 US8609644B2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
EA200870434A EA015257B1 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
HK09111966.8A HK1134821B (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
JP2009504741A JP5438503B2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstane and androstene as pharmaceuticals for cardiovascular disease
BRPI0709943-6A BRPI0709943A2 (en) 2006-04-13 2007-04-11 amino derivatives of androstanes and androstenes as medicines for cardiovascular disorders
EP07727992A EP2004668B1 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
CA2649175A CA2649175C (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
AU2007239518A AU2007239518B2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112598.5 2006-04-13
EP06112598 2006-04-13

Publications (2)

Publication Number Publication Date
WO2007118832A2 WO2007118832A2 (en) 2007-10-25
WO2007118832A3 true WO2007118832A3 (en) 2008-04-17

Family

ID=37268538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/053524 Ceased WO2007118832A2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Country Status (16)

Country Link
US (1) US8609644B2 (en)
EP (1) EP2004668B1 (en)
JP (1) JP5438503B2 (en)
KR (1) KR101424046B1 (en)
CN (1) CN101466725B (en)
AR (1) AR060427A1 (en)
AU (1) AU2007239518B2 (en)
BR (1) BRPI0709943A2 (en)
CA (1) CA2649175C (en)
EA (1) EA015257B1 (en)
ES (1) ES2405625T3 (en)
MX (1) MX2008012942A (en)
PL (1) PL2004668T3 (en)
PT (1) PT2004668E (en)
TW (1) TWI392682B (en)
WO (1) WO2007118832A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
JP5290189B2 (en) * 2006-11-30 2013-09-18 エンディース エルエルシー 6-Alkoxyalkylestradiol derivatives and uses thereof
HUE027408T2 (en) * 2009-03-23 2016-10-28 Sigma Tau Ind Farmaceuti 5-beta, 14-beta-androstane derivatives useful for the treatment of proteinuria, glomerulosclerosis and renal failure
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
JP2019508424A (en) * 2016-03-02 2019-03-28 パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー Processes and intermediates for the production of 17 (20) -ene B-secosteroids
JP7648538B2 (en) * 2019-04-27 2025-03-18 ヘルス リサーチ インコーポレイテッド Coumarin-modified androgens for the treatment of prostate cancer
DK3805243T3 (en) * 2019-10-09 2024-01-02 Windtree Therapeutics Inc ANDROSTANDE DERIVATIVES WITH ACTIVITY AS PURE OR SUBSTANTIALLY PURE STIMULATORS OF SERCA2A FOR THE TREATMENT OF HEART FAILURE
CN111040012B (en) * 2019-12-27 2022-04-15 山东安弘制药有限公司 Preparation method of exemestane spirooxirane impurity
CN120718029A (en) * 2025-06-20 2025-09-30 湖南中医药大学 A preparation method of natural product 6-HHS
CN121471044B (en) * 2026-01-09 2026-03-20 苏州大学 A method for synthesizing sulfoxide imine guanidine compounds catalyzed by cobalt dichloride

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) * 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
US3120515A (en) * 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3210386A (en) * 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
DE1187236B (en) 1961-03-28 1965-02-18 Searle & Co Process for the preparation of 17beta-amino steroids
US5522847A (en) * 1993-06-18 1996-06-04 Kalis; Amy G. Pacifier with novelty electronic display
US5662685A (en) * 1996-08-13 1997-09-02 Uhler; Gary S. Sound producing pacifier
US6066161A (en) * 1997-07-26 2000-05-23 Parella; Nicole D. X. Baby pacifier apparatus with remote control locator
DE19906159A1 (en) * 1999-02-09 2000-08-10 Schering Ag 16-hydroxyestratrienes as selectively active estrogens
ES2307064T3 (en) * 2003-11-26 2008-11-16 Bayer Schering Pharma Aktiengesellschaft PREVENTION AND TREATMENT OF HYPERTENSIVE CARDIAC DISEASES BY SELECTIVE STROGENS 8BETA-VINIL-ESTRA-1,3,5 (10) -TRIEN-3,17BETA-DIOL AND 17BETA-FLUOR-9ALFA-VINIL-ESTRA-1,3,5 ( 10) -TRIEN-3.16ALFA-DIOL.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) * 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US3120515A (en) * 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOORGANICHESKAYA KHIMIYA , 17(1), 141-3 CODEN: BIKHD7; ISSN: 0132-3423, 1991 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAMERNITSKII, A. V. ET AL: "A new class of cardiotonic steroids", XP002469943, retrieved from STN Database accession no. 1991:199372 *
DE MUNARI SERGIO ET AL: "Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds.", JOURNAL OF MEDICINAL CHEMISTRY. 14 AUG 2003, vol. 46, no. 17, 14 August 2003 (2003-08-14), pages 3644 - 3654, XP002406552, ISSN: 0022-2623 *
LE MEN J ET AL: "CHEMISTRY AND PHARMACOLOGY OF HEMI SYNTHETIC COMPOUNDS FOR CARDIO VASCULAR ACTIVITY DERIVATIVES OF PARAVALLARINE A NATURALLY OCCURRING STEROID", CHIMICA THERAPEUTICA, vol. 5, no. 1, 1970, pages 41 - 54, XP008088843, ISSN: 0009-4374 *
TEMMA, KYOSUKE ET AL: "Effects of progesterone derivatives on sodium pump activity and force of myocardial contraction in isolated guinea pig heart", RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY , 41(1), 51-63 CODEN: RCOCB8; ISSN: 0034-5164, 1983, XP002406556 *
ULUBELEN A ET AL: "Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 66, no. 7, 2000, pages 627 - 629, XP003014892, ISSN: 0032-0943 *

Also Published As

Publication number Publication date
JP2009533392A (en) 2009-09-17
CN101466725B (en) 2014-06-25
EP2004668A2 (en) 2008-12-24
BRPI0709943A2 (en) 2011-08-02
HK1134821A1 (en) 2010-05-14
MX2008012942A (en) 2008-10-17
WO2007118832A2 (en) 2007-10-25
PT2004668E (en) 2013-04-30
US20110053902A1 (en) 2011-03-03
ES2405625T3 (en) 2013-05-31
AU2007239518A1 (en) 2007-10-25
US8609644B2 (en) 2013-12-17
CA2649175C (en) 2015-01-27
CN101466725A (en) 2009-06-24
CA2649175A1 (en) 2007-10-25
JP5438503B2 (en) 2014-03-12
EA015257B1 (en) 2011-06-30
EA200870434A1 (en) 2009-04-28
TWI392682B (en) 2013-04-11
TW200804406A (en) 2008-01-16
KR20080111532A (en) 2008-12-23
AU2007239518B2 (en) 2012-03-15
EP2004668B1 (en) 2013-03-13
AU2007239518A2 (en) 2008-11-27
PL2004668T3 (en) 2013-07-31
AR060427A1 (en) 2008-06-18
KR101424046B1 (en) 2014-07-28

Similar Documents

Publication Publication Date Title
WO2007118832A3 (en) Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
MX2008012943A (en) Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders.
WO2008024497A3 (en) INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1
WO2009010416A3 (en) Inhibitors of 11b-hydroxysteroid dehydrogenase
WO2009075835A8 (en) CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
WO2008106128A3 (en) CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
WO2007082808A3 (en) Thiazoles as 11 beta-hsd1 inhibitors
NO20072608L (en) Biaryloksymetylarenkarboksylsyrer
WO2005082863A3 (en) 1,4 diaryl-dihydropyrimidin-2 ones and their use as a human neutrophil elastase inhibitors
WO2005116002A3 (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
NO20073628L (en) Pyridones useful as inhibitors of kinases
WO2007107470A3 (en) Pyrazoles as 11-beta-hsd-1
WO2009064460A3 (en) Gastrointestinal delivery systems
WO2008094992A3 (en) 2-aminopyridine derivatives useful as kinase inhibitors
WO2008034796A3 (en) Estratriene derivatives and their uses as 17beta-hydr0xyster0id dehydrogenase inhibitors
WO2010010157A3 (en) INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2007127505A3 (en) Use of sulfonamide derivatives in the treatment of disorders of the metabolism and the nervous system
WO2007106537A3 (en) Aminoquinolones as gsk-3 inhibitors
NO20085064L (en) 4,5-diphenyl-pyrimidinyl-oxy or mercapto-substituted carboxylic acids, processes for their preparation and use thereof as medicaments
WO2009071480A3 (en) Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
DK2324008T3 (en) Diarylpyrazole as protein kinase inhibitors
WO2007135527A3 (en) Benzimidazolyl compounds
MX2009005201A (en) Substituted estratrien derivatives as 17beta hsd inhibitors.
WO2008006795A3 (en) Indole compounds
NO20064489L (en) Sulfated oligosaccharide derivatives

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780022229.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07727992

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2007727992

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: MX/a/2008/012942

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2649175

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007239518

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 4141/KOLNP/2008

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2009504741

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 2007239518

Country of ref document: AU

Date of ref document: 20070411

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020087027712

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 200870434

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 12295497

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0709943

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20081013