WO2007124085A3 - Device for quantification of radioisotope concentrations in a micro-fluidic platform - Google Patents

Device for quantification of radioisotope concentrations in a micro-fluidic platform Download PDF

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Publication number
WO2007124085A3
WO2007124085A3 PCT/US2007/009705 US2007009705W WO2007124085A3 WO 2007124085 A3 WO2007124085 A3 WO 2007124085A3 US 2007009705 W US2007009705 W US 2007009705W WO 2007124085 A3 WO2007124085 A3 WO 2007124085A3
Authority
WO
WIPO (PCT)
Prior art keywords
micro
fluidic
quantification
circuit layer
charged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/009705
Other languages
French (fr)
Other versions
WO2007124085A2 (en
Inventor
Arion-Xenofon F Hadjioannou
Vu Nam
Tak For Yu
Hsian-Rong Tseng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2009506611A priority Critical patent/JP2009534661A/en
Priority to US12/296,825 priority patent/US20090302228A1/en
Priority to EP07755823A priority patent/EP2016193A2/en
Publication of WO2007124085A2 publication Critical patent/WO2007124085A2/en
Publication of WO2007124085A3 publication Critical patent/WO2007124085A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measurement Of Radiation (AREA)

Abstract

A micro-fluidic device has a micro-fluidic circuit layer and a charged-particle detection layer disposed proximate the micro-fluidic circuit layer. The micro-fluidic device is constructed to provide a two-dimensional image of charged-particle emissions from a sample within the micro-fluidic circuit layer while in operation. A method of quantification of radioactivity in a biological sample includes directing a fluid containing the biological material into a microfluidic device, detecting charged particles emitted from the biological material with a two-dimensional imaging sensor, and forming a two-dimensional image over time corresponding to radioactivity of the biological sample.
PCT/US2007/009705 2006-04-20 2007-04-20 Device for quantification of radioisotope concentrations in a micro-fluidic platform Ceased WO2007124085A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009506611A JP2009534661A (en) 2006-04-20 2007-04-20 Microfluidic platform radioisotope concentration quantification device
US12/296,825 US20090302228A1 (en) 2006-04-20 2007-04-20 Device for quantification of radioisotope concentrations in a micro-fluidic platform
EP07755823A EP2016193A2 (en) 2006-04-20 2007-04-20 Device for quantification of radioisotope concentrations in a micro-fluidic platform

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79324106P 2006-04-20 2006-04-20
US60/793,241 2006-04-20
US83261506P 2006-07-24 2006-07-24
US60/832,615 2006-07-24

Publications (2)

Publication Number Publication Date
WO2007124085A2 WO2007124085A2 (en) 2007-11-01
WO2007124085A3 true WO2007124085A3 (en) 2008-03-20

Family

ID=38625629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009705 Ceased WO2007124085A2 (en) 2006-04-20 2007-04-20 Device for quantification of radioisotope concentrations in a micro-fluidic platform

Country Status (4)

Country Link
US (1) US20090302228A1 (en)
EP (1) EP2016193A2 (en)
JP (1) JP2009534661A (en)
WO (1) WO2007124085A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110303343A1 (en) * 2010-06-09 2011-12-15 Origio, Inc. Microfluidic bonding technology
WO2012034094A2 (en) * 2010-09-09 2012-03-15 The Regents Of The University Of California Integrated microfluidic radioassay and imaging platform for small sample analysis
US8304738B2 (en) * 2010-10-19 2012-11-06 Kabushiki Kaisha Toshiba Pet detector scintillation light guiding system having fiber-optics plates
ITTO20110649A1 (en) * 2011-07-19 2013-01-20 St Microelectronics Srl PHOTORELECTRIC DEVICE WITH PROTECTIVE AND ANTI-REFLECTIVE COVER, AND RELATIVE MANUFACTURING METHOD
US8963095B2 (en) * 2012-11-27 2015-02-24 Diagnostic Chips, LLC Electrokinetic microfluidic flow cytometer apparatuses with differential resistive particle counting and optical sorting
US9239328B2 (en) * 2012-12-17 2016-01-19 Taiwan Semiconductor Manufacturing Company, Ltd. Systems and methods for an integrated bio-entity manipulation and processing semiconductor device
US9366647B2 (en) 2013-03-14 2016-06-14 Taiwan Semiconductor Manufacturing Company, Ltd. Optical detection for bio-entities
DK2923754T3 (en) * 2014-03-26 2019-11-11 Corning Inc Modular photochemical flow reactor system
US10473668B2 (en) * 2014-06-06 2019-11-12 The Regents Of The University Of California Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette
US9606245B1 (en) 2015-03-24 2017-03-28 The Research Foundation For The State University Of New York Autonomous gamma, X-ray, and particle detector
GB201604246D0 (en) * 2016-03-11 2016-04-27 Univ Hull Radioactivity detection
US11660571B2 (en) * 2016-11-18 2023-05-30 The Regents Of The University Of California Microscale device and method for purification of radiopharmaceuticals
IL278076B2 (en) * 2018-04-20 2025-08-01 Asml Netherlands Bv Selection of segment shape and pixel shape for high-speed detector with large active area

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US7118910B2 (en) * 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
US7244598B2 (en) * 2000-08-14 2007-07-17 Surface Logix, Inc. Biomolecule arrays

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059800A (en) * 1991-04-19 1991-10-22 General Electric Company Two dimensional mosaic scintillation detector
AU1517999A (en) * 1997-10-15 1999-05-03 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US6895077B2 (en) * 2001-11-21 2005-05-17 University Of Massachusetts Medical Center System and method for x-ray fluoroscopic imaging
CA2521171C (en) * 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
KR100580639B1 (en) * 2003-12-30 2006-05-16 삼성전자주식회사 Fluorescence Detector for Microfluidic Detection
EP1838431A4 (en) * 2004-12-03 2012-08-22 California Inst Of Techn MICROFLUIDIC DEVICES WITH CIRCUITS FOR CHEMICAL REACTIONS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6589729B2 (en) * 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
US7244598B2 (en) * 2000-08-14 2007-07-17 Surface Logix, Inc. Biomolecule arrays
US7118910B2 (en) * 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same

Also Published As

Publication number Publication date
WO2007124085A2 (en) 2007-11-01
JP2009534661A (en) 2009-09-24
US20090302228A1 (en) 2009-12-10
EP2016193A2 (en) 2009-01-21

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