WO2007128495A3 - Solid pharmaceutical composition of gabapentin - Google Patents

Solid pharmaceutical composition of gabapentin Download PDF

Info

Publication number
WO2007128495A3
WO2007128495A3 PCT/EP2007/003914 EP2007003914W WO2007128495A3 WO 2007128495 A3 WO2007128495 A3 WO 2007128495A3 EP 2007003914 W EP2007003914 W EP 2007003914W WO 2007128495 A3 WO2007128495 A3 WO 2007128495A3
Authority
WO
WIPO (PCT)
Prior art keywords
gabapentin
solid
phase
pharmaceutical composition
solid pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/003914
Other languages
French (fr)
Other versions
WO2007128495A2 (en
Inventor
Perez Sergio Lloret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Combino Pharm SL
Original Assignee
Combino Pharm SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combino Pharm SL filed Critical Combino Pharm SL
Priority to EP07785797A priority Critical patent/EP2020993A2/en
Publication of WO2007128495A2 publication Critical patent/WO2007128495A2/en
Publication of WO2007128495A3 publication Critical patent/WO2007128495A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to solid pharmaceutical compositions of gabapentin that have good stability and good bioavailability of the active principle, and that can be used for preparing pharmaceutical solid forms of gabapentin for oral administration. The pharmaceutical composition of the invention is a solid composition comprising an intragranular phase and an extragranular phase. It is a solid composition that is of a granular appearance, but includes non-granulated particles of the extragranular phase. The invention lays on the incorporation of a hydrophobic compound in the intragranular phase, and a humsctant in the extragranular phase which leads to the preparation of solid compositions of gabapentin that have good stability and good bioavailability of the gabapentin.
PCT/EP2007/003914 2006-05-08 2007-05-03 Solid pharmaceutical composition of gabapentin Ceased WO2007128495A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07785797A EP2020993A2 (en) 2006-05-08 2007-05-03 Solid pharmaceutical composition of gabapentin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200601164A ES2288117B1 (en) 2006-05-08 2006-05-08 SOLID PHARMACEUTICAL COMPOSITION OF GABAPENTINA.
ES200601164 2006-05-08

Publications (2)

Publication Number Publication Date
WO2007128495A2 WO2007128495A2 (en) 2007-11-15
WO2007128495A3 true WO2007128495A3 (en) 2008-05-02

Family

ID=38668112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/003914 Ceased WO2007128495A2 (en) 2006-05-08 2007-05-03 Solid pharmaceutical composition of gabapentin

Country Status (4)

Country Link
EP (1) EP2020993A2 (en)
AR (1) AR060869A1 (en)
ES (1) ES2288117B1 (en)
WO (1) WO2007128495A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009012788A1 (en) * 2009-03-13 2010-09-30 J. Rettenmaier & Söhne Gmbh + Co. Kg Compressible tablet material with oily agent, tablet and method and apparatus for their preparation
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
US10342886B2 (en) 2016-01-26 2019-07-09 S.C. Johnson & Son, Inc. Extruded wax melt and method of producing same
US10010638B2 (en) 2016-06-14 2018-07-03 S. C. Johnson & Son, Inc. Wax melt with filler
CN111698992A (en) 2017-08-18 2020-09-22 艾伯维公司 Pharmaceutical formulation for the treatment of endometriosis, uterine fibroids, polycystic ovarian syndrome or adenomyosis
TW201912157A (en) 2017-08-18 2019-04-01 美商艾伯維有限公司 Solid pharmaceutical formulation for the treatment of endometriosis, uterine fibroids, polycystic ovary syndrome and adenomyosis
GB2625579A (en) * 2022-12-21 2024-06-26 Novumgen Ltd An orally disintegrating tablet containing gabapentin or pharmaceutically acceptable salts thereof and the process of preparing the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076478A1 (en) * 1999-06-14 2000-12-21 Cosmo S.P.A. Controlled release and taste masking oral pharmaceutical compositions
WO2002026263A2 (en) * 2000-09-26 2002-04-04 Sigmapharm, Inc. Stable solid dosage forms of amino acids and processes for producing same
WO2003002151A1 (en) * 2001-06-26 2003-01-09 Farmatron Ltd. Oral pharmaceutical compositions with modified release of the active ingredient
WO2003103634A1 (en) * 2002-06-07 2003-12-18 Ranbaxy Laboratories Limited Sustained release oral dosage forms of gabapentin
WO2005099674A1 (en) * 2004-04-14 2005-10-27 Vectura Limited Pharmaceutical compositions comprising an amphiphilic starch

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2470636A1 (en) * 2001-12-20 2003-07-03 Pharmacia Corporation Zero-order sustained released dosage forms and method of making the same
CN1720025A (en) * 2002-10-08 2006-01-11 兰贝克赛实验室有限公司 Gabapentin tablets and methods for their preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076478A1 (en) * 1999-06-14 2000-12-21 Cosmo S.P.A. Controlled release and taste masking oral pharmaceutical compositions
WO2002026263A2 (en) * 2000-09-26 2002-04-04 Sigmapharm, Inc. Stable solid dosage forms of amino acids and processes for producing same
WO2003002151A1 (en) * 2001-06-26 2003-01-09 Farmatron Ltd. Oral pharmaceutical compositions with modified release of the active ingredient
WO2003103634A1 (en) * 2002-06-07 2003-12-18 Ranbaxy Laboratories Limited Sustained release oral dosage forms of gabapentin
WO2005099674A1 (en) * 2004-04-14 2005-10-27 Vectura Limited Pharmaceutical compositions comprising an amphiphilic starch

Also Published As

Publication number Publication date
ES2288117B1 (en) 2008-12-01
EP2020993A2 (en) 2009-02-11
AR060869A1 (en) 2008-07-16
ES2288117A1 (en) 2007-12-16
WO2007128495A2 (en) 2007-11-15

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