WO2007133865A3 - Hcv/hiv inhibitors an their uses - Google Patents

Hcv/hiv inhibitors an their uses Download PDF

Info

Publication number
WO2007133865A3
WO2007133865A3 PCT/US2007/066204 US2007066204W WO2007133865A3 WO 2007133865 A3 WO2007133865 A3 WO 2007133865A3 US 2007066204 W US2007066204 W US 2007066204W WO 2007133865 A3 WO2007133865 A3 WO 2007133865A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
hiv inhibitors
hiv
inhibitors
amelioration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/066204
Other languages
French (fr)
Other versions
WO2007133865A2 (en
Inventor
Trixi Brandl
Jiping Fu
Francois Lenoir
David Thomas Parker
Michael Patane
Branko Radetich
Prakash Raman
Pascal Rigollier
Mohindra Seepersaud
Oliver Simic
Aregahegn Yifru
Rui Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38617501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007133865(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HK09105830.4A priority Critical patent/HK1126798B/en
Priority to CA002643680A priority patent/CA2643680A1/en
Priority to CN2007800213542A priority patent/CN101466727B/en
Priority to EP20070811837 priority patent/EP2007789B1/en
Priority to AU2007249668A priority patent/AU2007249668B2/en
Priority to UAA200811685A priority patent/UA100666C2/en
Priority to KR1020087027485A priority patent/KR101059593B1/en
Priority to ES07811837.9T priority patent/ES2543840T3/en
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to BRPI0710878 priority patent/BRPI0710878A2/en
Priority to JP2009505555A priority patent/JP5167244B2/en
Priority to MX2008013119A priority patent/MX2008013119A/en
Priority to NZ571826A priority patent/NZ571826A/en
Publication of WO2007133865A2 publication Critical patent/WO2007133865A2/en
Publication of WO2007133865A3 publication Critical patent/WO2007133865A3/en
Priority to IL194434A priority patent/IL194434A0/en
Priority to TNP2008000400A priority patent/TNSN08400A1/en
Anticipated expiration legal-status Critical
Priority to NO20084749A priority patent/NO20084749L/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

The present application describes organic compounds of formula (I): that are useful for the treatment, prevention and/or amelioration of human diseases such as HCV and HIV.
PCT/US2007/066204 2006-04-11 2007-04-09 Hcv/hiv inhibitors an their uses Ceased WO2007133865A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2009505555A JP5167244B2 (en) 2006-04-11 2007-04-09 HCV / HIV inhibitors and their use
CA002643680A CA2643680A1 (en) 2006-04-11 2007-04-09 Hcv/hiv inhibitors and their uses
CN2007800213542A CN101466727B (en) 2006-04-11 2007-04-09 HCV/HIV inhibitors and uses thereof
EP20070811837 EP2007789B1 (en) 2006-04-11 2007-04-09 Spirocyclic HCV/HIV inhibitors and their uses
AU2007249668A AU2007249668B2 (en) 2006-04-11 2007-04-09 HCV/HIV inhibitors and their uses
UAA200811685A UA100666C2 (en) 2006-04-11 2007-04-09 Hcv/hiv inhibitors and their uses
KR1020087027485A KR101059593B1 (en) 2006-04-11 2007-04-09 HCl / HIV inhibitors and uses thereof
ES07811837.9T ES2543840T3 (en) 2006-04-11 2007-04-09 Spirocyclic HCV / HIV inhibitors and their uses
BRPI0710878 BRPI0710878A2 (en) 2006-04-11 2007-04-09 Organic compounds and their uses
HK09105830.4A HK1126798B (en) 2006-04-11 2007-04-09 Spirocyclic hcv/hiv inhibitors and their uses
NZ571826A NZ571826A (en) 2006-04-11 2007-04-09 HCV/HIV inhibitors and their uses
MX2008013119A MX2008013119A (en) 2006-04-11 2007-04-09 Hcv/hiv inhibitors an their uses.
IL194434A IL194434A0 (en) 2006-04-11 2008-09-28 Hcv/hiv inhibitors and their uses
TNP2008000400A TNSN08400A1 (en) 2006-04-11 2008-10-10 Organic compounds and their uses
NO20084749A NO20084749L (en) 2006-04-11 2008-11-10 Organic compounds and their applications

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79131806P 2006-04-11 2006-04-11
US60/791,318 2006-04-11
US86687406P 2006-11-22 2006-11-22
US60/866,874 2006-11-22

Publications (2)

Publication Number Publication Date
WO2007133865A2 WO2007133865A2 (en) 2007-11-22
WO2007133865A3 true WO2007133865A3 (en) 2008-07-10

Family

ID=38617501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/066204 Ceased WO2007133865A2 (en) 2006-04-11 2007-04-09 Hcv/hiv inhibitors an their uses

Country Status (26)

Country Link
US (4) US7825152B2 (en)
EP (2) EP2007789B1 (en)
JP (1) JP5167244B2 (en)
KR (1) KR101059593B1 (en)
CN (1) CN101466727B (en)
AR (1) AR060405A1 (en)
AU (1) AU2007249668B2 (en)
BR (1) BRPI0710878A2 (en)
CA (1) CA2643680A1 (en)
CL (1) CL2007001005A1 (en)
CR (1) CR10336A (en)
EC (1) ECSP088811A (en)
ES (1) ES2543840T3 (en)
IL (1) IL194434A0 (en)
MA (1) MA30392B1 (en)
MX (1) MX2008013119A (en)
MY (1) MY147247A (en)
NO (1) NO20084749L (en)
NZ (1) NZ571826A (en)
PE (2) PE20121157A1 (en)
RU (1) RU2448976C2 (en)
SG (1) SG173368A1 (en)
TN (1) TNSN08400A1 (en)
TW (1) TWI341207B (en)
UA (1) UA100666C2 (en)
WO (1) WO2007133865A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008001166A (en) 2005-07-25 2008-03-18 Intermune Inc Novel macrocyclic inhibitors of hepatitis c virus replication.
AU2006301966A1 (en) 2005-10-11 2007-04-19 Array Biopharma, Inc. Compounds and methods for inhibiting hepatitis C viral replication
EP2007789B1 (en) 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
KR20090024834A (en) 2006-07-05 2009-03-09 인터뮨, 인크. New Inhibitors of Hepatitis C Virus Replication
WO2008141227A1 (en) * 2007-05-10 2008-11-20 Intermune, Inc. Novel peptide inhibitors of hepatitis c virus replication
AR068756A1 (en) * 2007-10-10 2009-12-02 Novartis Ag PEPTIDIC COMPOUNDS, PHARMACEUTICAL FORMULATION AND ITS USES AS MODULATORS OF THE HEPATITIS C VIRUS
EP2279011B1 (en) 2008-04-30 2017-10-25 Siemens Medical Solutions USA, Inc. Substrate based pet imaging agents
US20090285774A1 (en) * 2008-05-15 2009-11-19 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US20110182850A1 (en) * 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
US20130338061A1 (en) * 2010-10-08 2013-12-19 Lipa Shah Salts and Polymorphs of Sulfamide NS3 Inhibitors
JP5909495B2 (en) * 2010-10-08 2016-04-26 ノバルティス アーゲー Vitamin E formulation of sulfamide NS3 inhibitor
WO2013025858A1 (en) * 2011-08-16 2013-02-21 Glaxosmithkline Llc 5-benzyl-n-phenyethyl-1,3,4-oxadiazole-2-carboxamide derivatives
EP2871181B1 (en) * 2013-11-12 2016-10-05 Acousia Therapeutics GmbH Novel Compounds for Regeneration of Terminally-Differentiated Cells and tissues
CN105769860A (en) * 2016-04-18 2016-07-20 乔海灵 Application of clomethiazole as medicine for preventing and treating liver and esophageal disease
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
PL3472149T3 (en) 2016-06-21 2024-02-12 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
EP3497080A4 (en) * 2016-08-08 2020-07-29 Signum Biosciences, Inc. Pharmaceutical formulations and their use
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0326974A1 (en) * 1988-02-04 1989-08-09 Hoechst Aktiengesellschaft Amino acid amides with a psychotropic activity, processes for their preparation, compositions containing them and their use
US20030036501A1 (en) * 2000-07-21 2003-02-20 Saksena Anil K. Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
WO2003062265A2 (en) * 2002-01-18 2003-07-31 Schering Corporation Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
US20030216325A1 (en) * 2000-07-21 2003-11-20 Saksena Anil K Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
US20050107304A1 (en) * 2003-07-18 2005-05-19 Britt Shawn D. Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US20050137140A1 (en) * 2003-10-10 2005-06-23 Cottrell Kevin M. Inhibitors of serine proteases, particularly HCV NS3-NS4A proteases
US20050267043A1 (en) * 2004-02-27 2005-12-01 Schering Corporation Novel inhibitors of hepatitis C virus NS3 protease
WO2006017295A2 (en) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
WO2007025307A2 (en) * 2005-08-26 2007-03-01 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
USRE29835E (en) 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4917888A (en) 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (en) 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー Chemically modified protein, its production method and intermediate
US5041426A (en) 1987-12-21 1991-08-20 Brigham Young University Immune system enhancing 3-β-d-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and nucleotides
KR0148748B1 (en) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 Pharmaceutical composition containing cyclosporin
US5026687A (en) 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
DE69133402T2 (en) 1990-04-04 2004-11-11 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville PROTEASE OF HEPATITIS-C VIRUS
DE69132332T2 (en) 1990-04-06 2000-11-30 Genelabs Technologies, Inc. HEPATITIS C-VIRUS-EPITOPE
FI111730B (en) 1990-11-02 2003-09-15 Novartis Ag Process for the preparation of non-immunosuppressive cyclosporins
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5610054A (en) 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
DE69321823T2 (en) 1992-10-21 1999-06-02 Taito Co., Ltd., Tokio/Tokyo 2-AMINO-1, 3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSIUM
CA2170020C (en) 1992-12-29 2005-08-02 Dale J. Kempf Retroviral protease inhibiting compounds
US5496546A (en) 1993-02-24 1996-03-05 Jui H. Wang Compositions and methods of application of reactive antiviral polyadenylic acid derivatives
US5846964A (en) 1993-07-19 1998-12-08 Tokyo Tanabe Company Limited Hepatitis C virus proliferation inhibitor
ATE214940T1 (en) 1993-11-10 2002-04-15 Enzon Inc IMPROVED INTERFERON-POLYMER CONJUGATES
DE4415539C2 (en) 1994-05-03 1996-08-01 Osama Dr Dr Med Omer Plants with virustatic and antiviral effects
EP0778263B1 (en) 1994-08-22 2002-01-09 Welfide Corporation Benzene compound and medicinal use thereof
DE4432623A1 (en) 1994-09-14 1996-03-21 Huels Chemische Werke Ag Process for bleaching aqueous surfactant solutions
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JP3786447B2 (en) 1995-03-31 2006-06-14 エーザイ株式会社 Preventive and therapeutic agent for hepatitis C
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
AU2064297A (en) 1996-02-29 1997-09-16 Immusol, Inc Hepatitis c virus ribozymes
US5633388A (en) 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
US5830905A (en) 1996-03-29 1998-11-03 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
HUP0004421A3 (en) 1996-04-23 2002-10-28 Vertex Pharmaceuticals Inc Cam Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme
US5990276A (en) 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
US5891874A (en) 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5837257A (en) 1996-07-09 1998-11-17 Sage R&D Use of plant extracts for treatment of HIV, HCV and HBV infections
JP3927630B2 (en) 1996-09-27 2007-06-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Preventive and therapeutic agents for viral infections
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
KR100509388B1 (en) 1996-10-18 2005-08-23 버텍스 파마슈티칼스 인코포레이티드 Inhibitors Of Serine Proteases, Particularly Hepatitis C Virus NS3 Protease
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
IL119833A (en) 1996-12-15 2001-01-11 Lavie David Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
EP0966465B1 (en) 1997-03-14 2003-07-09 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
ES2240868T3 (en) 1997-04-04 2005-10-16 Mitsubishi Pharma Corporation COMPOSITE OF 2-AMINOPROPANE -1,3-DIOL, ITS PHARMACEUTICAL USE AND INTERMEDIATES IN ITS SYNTHESIS
US6004933A (en) 1997-04-25 1999-12-21 Cortech Inc. Cysteine protease inhibitors
KR100630506B1 (en) 1997-06-30 2006-09-29 메르츠 파마 게엠베하 운트 코. 카가아 1-amino-alkylcyclohexane compound as NMDA receptor antagonist, pharmaceutical composition containing the same and method of treating with it
ES2234144T3 (en) 1997-08-11 2005-06-16 Boehringer Ingelheim (Canada) Ltd. ANALOGS OF INHIBITING PEPTIDES OF HEPATITIS C.
WO1999043691A1 (en) 1998-02-25 1999-09-02 Emory University 2'-fluoronucleosides
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
PT2415776T (en) 1998-08-10 2016-07-07 Novartis Ag Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis b
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AP1498A (en) 1999-03-19 2005-11-21 Vertex Pharma Inhibitors of impdh enzyme.
ID30355A (en) 1999-04-07 2001-11-22 Pfizer Prod Inc USE OF CYP2D6 INHIBITORS IN COMBINATION THERAPY
ATE255203T1 (en) 1999-09-06 2003-12-15 Innovationen Zur Verbrennungst METHOD FOR OPERATING A MOTOR VEHICLE COMBUSTION ENGINE
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
KR20030005197A (en) 2000-02-18 2003-01-17 샤이어 바이오켐 인코포레이티드 Method for the treatment or prevention of Flavivirus infections using nucleoside analogues
EP1964569A3 (en) 2000-04-13 2009-07-22 Pharmasset, Inc. 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1736478B1 (en) 2000-05-26 2015-07-22 IDENIX Pharmaceuticals, Inc. Methods and compositions for treating flaviviruses and pestiviruses
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
CN1328387C (en) 2000-07-13 2007-07-25 三共株式会社 Amino alcohol derivatives
CA2418199A1 (en) 2000-07-21 2002-01-31 Corvas International, Inc. Peptides as ns3-serine protease inhibitors of hepatitis c virus
KR20030081297A (en) 2000-07-21 2003-10-17 쉐링 코포레이션 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
AU2001255070A1 (en) 2000-08-28 2002-03-13 Jin-Sub Kim Generator of two-wheeled vehicle and lighting system thereby
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
SV2003000617A (en) 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
EP1315735A4 (en) 2000-08-31 2005-04-06 Merck & Co Inc PHOSPHATE DERIVATIVES AS IMMUNO-REGULATING AGENTS
WO2002032920A2 (en) 2000-10-18 2002-04-25 Pharmasset Limited Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
DE60119968T2 (en) 2000-11-20 2007-01-18 Bristol-Myers Squibb Co. HEPATITIS C TRIPEPTIDE INHIBITORS
KR20030091946A (en) 2000-12-12 2003-12-03 쉐링 코포레이션 Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus
AU2002230764A1 (en) 2000-12-13 2002-06-24 Bristol-Myers Squibb Pharma Company Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
AU2002230763A1 (en) 2000-12-13 2008-01-03 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
WO2002048165A2 (en) 2000-12-15 2002-06-20 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
SK286630B6 (en) 2001-01-22 2009-02-05 Merck & Co., Inc. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase, pharmaceutical composition containing said compounds and the use thereof
DE10102928B4 (en) 2001-01-23 2004-03-04 Infineon Technologies Ag Viterbi decoder and method for decoding
CA2442178A1 (en) 2001-03-26 2002-10-03 Novartis Ag 2-amino-propanol derivatives
JP2002316985A (en) 2001-04-20 2002-10-31 Sankyo Co Ltd Benzothiophene derivative
CA2461212C (en) 2001-09-27 2010-08-17 Kyorin Pharmaceutical Co., Ltd. Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same
DE60235900D1 (en) 2001-09-27 2010-05-20 Kyorin Seiyaku Kk OSUPPRESSIVUM
EP1435974A4 (en) * 2001-09-28 2006-09-06 Idenix Cayman Ltd METHOD AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS WITH 4'-MODIFIED NUCLEOSIDES
AP2004003069A0 (en) 2001-11-27 2004-06-30 Anadys Pharmaceuticals Inc 3-beta-d-ribofuranosynthiazolo [4-5-d] pyridimine nucleosides and uses thereof.
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
US6973322B2 (en) 2001-12-22 2005-12-06 International Business Machines Corporation Personal travel agent using push services
ATE448193T1 (en) 2002-01-18 2009-11-15 Merck & Co Inc ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTSß
JP4430941B2 (en) 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Edg receptor agonist
US6894072B2 (en) * 2002-01-23 2005-05-17 Schering Corporation Compounds as NS3-serine protease inhibitors of hepatitis C virus
KR20040099425A (en) * 2002-04-11 2004-11-26 버텍스 파마슈티칼스 인코포레이티드 Inhibitors of serine proteases, particularly hepatitis c virus ns3-ns4 protease
MY140680A (en) * 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
CN1678326A (en) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 2'-C-methyl-3'-O-L-valine ester ribofuranocytidine for the treatment of flavivirus infection
BRPI0410967A (en) 2003-06-04 2006-07-04 Genelabs Tech Inc compounds, compositions and their uses for the treatment of virus infections of the family flaviviridae
ES2354817T3 (en) 2003-06-17 2011-03-18 Schering Corporation PROCEDURE AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 3-AZABICICLO [3.1.0] HEXANO-2-CARBOXILATOS OF (1R, 2S, 5S) -6,6-DIMETHYL OR ITS SALTS.
JP2007501189A (en) 2003-08-01 2007-01-25 ジェネラブス テクノロジーズ，インコーポレイテッド Bicyclic imidazole derivatives for Flaviviridae
US7449447B2 (en) 2003-08-26 2008-11-11 Schering Corporation Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus
TWI359147B (en) 2003-09-05 2012-03-01 Vertex Pharma Inhibitors of serine proteases, particularly hcv n
JP2007504232A (en) 2003-09-05 2007-03-01 アナディス ファーマシューティカルズ インク Administration of TLR7 ligand and prodrug thereof for the treatment of hepatitis C virus infection
EP1664091A1 (en) 2003-09-18 2006-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
JP2007509950A (en) * 2003-10-27 2007-04-19 バーテックス　ファーマシューティカルズ　インコーポレイテッド HCV treatment combination
WO2005058821A1 (en) 2003-12-11 2005-06-30 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease
CN1938332B (en) 2004-02-04 2011-10-19 沃泰克斯药物股份有限公司 Inhibitors of serine proteases, particularly HCV NS3-HS4A protease
HUE027902T2 (en) 2004-02-09 2016-11-28 Human Genome Sciences Inc Corp Service Company Albumin fusion proteins
JP4874227B2 (en) * 2004-02-27 2012-02-15 シェーリング コーポレイション Novel ketoamide with cyclic P4'S as NS3 serine protease inhibitor of hepatitis C virus
DE602005021760D1 (en) 2004-02-27 2010-07-22 Schering Corp SULFUR COMPOUNDS AS INHIBITORS OF THE NS3 SERINE PROTEASE OF HEPATITIS C VIRUS
EP1737821B1 (en) * 2004-02-27 2009-08-05 Schering Corporation 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease
CN1946691A (en) * 2004-02-27 2007-04-11 先灵公司 Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
US7635694B2 (en) * 2004-02-27 2009-12-22 Schering Corporation Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease
AR049635A1 (en) * 2004-05-06 2006-08-23 Schering Corp (1R, 2S, 5S) -N - ((1S) -3-AMINO-1- (CYCLLOBUTILMETIL) -2,3-DIOXOPROPIL) -3 - ((2S) -2 - (((((1,1-DIMETILETIL ) AMINO) CARBONIL) AMINO) -3,3-DIMETIL-1-OXOBUTIL) -6,6-DIMETIL-3-AZABICICLO (3.1.0) HEXAN-2-CARBOXAMIDE AS INHIBITOR OF THE NS3 / NS4A SERINA PROTEASA DEL VIRUS DE HEPATITIS C
CA2566541C (en) 2004-06-07 2012-10-09 Anadys Pharmaceuticals, Inc. 3-.beta.-d-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
AR049297A1 (en) 2004-06-08 2006-07-12 Vertex Pharma A PHARMACEUTICAL COMPOSITION AND SOLID DISPERSIONS OF VX-950 (INHIBITOR OF THE HCV PROTEASE NS3 / 4A) AND OBTAINING PROCESS
ATE513844T1 (en) * 2004-08-27 2011-07-15 Schering Corp ACYLSULFONAMIDE COMPOUNDS AS INHIBITORS OF THE NS3 SERINE PROTEASE OF THE HEPATITIS C VIRUS
RU2007116265A (en) 2004-10-01 2008-11-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) HCV VIRUS NS3-NS4A INHIBITION
SI1802650T1 (en) 2004-10-01 2012-03-30 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
DK1793844T3 (en) 2004-10-01 2011-03-21 Debiopharm Sa Use of [D-MeAla] 3- [EtVal] 4-cyclosporin for the treatment of hepatitis C infection
TW201424733A (en) 2004-10-29 2014-07-01 Vertex Pharma Dose forms
CN101103026A (en) 2005-01-14 2008-01-09 健亚生物科技公司 Indole derivatives for the treatment of viral infections
US20060281689A1 (en) * 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
US20060276404A1 (en) 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
AU2006252519B2 (en) 2005-06-02 2012-08-30 Merck Sharp & Dohme Corp. HCV protease inhibitors in combination with food
US20070004635A1 (en) 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
US20070021351A1 (en) 2005-06-02 2007-01-25 Schering Corporation Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor
US7608592B2 (en) 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
KR20080033481A (en) 2005-08-02 2008-04-16 버텍스 파마슈티칼스 인코포레이티드 Inhibitors of Serine Protease
BRPI0710153A2 (en) 2006-04-11 2011-08-02 Novartis Ag organic compounds and their uses
AR060385A1 (en) 2006-04-11 2008-06-11 Novartis Ag ORGANIC COMPOUNDS AND THEIR USES
WO2007120595A2 (en) 2006-04-11 2007-10-25 Novartis Ag Amines for the treatment of hcv
EP2007789B1 (en) * 2006-04-11 2015-05-20 Novartis AG Spirocyclic HCV/HIV inhibitors and their uses
AR068756A1 (en) * 2007-10-10 2009-12-02 Novartis Ag PEPTIDIC COMPOUNDS, PHARMACEUTICAL FORMULATION AND ITS USES AS MODULATORS OF THE HEPATITIS C VIRUS
US8512690B2 (en) * 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0326974A1 (en) * 1988-02-04 1989-08-09 Hoechst Aktiengesellschaft Amino acid amides with a psychotropic activity, processes for their preparation, compositions containing them and their use
US20030036501A1 (en) * 2000-07-21 2003-02-20 Saksena Anil K. Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
US20030216325A1 (en) * 2000-07-21 2003-11-20 Saksena Anil K Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
WO2003062265A2 (en) * 2002-01-18 2003-07-31 Schering Corporation Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
US20050107304A1 (en) * 2003-07-18 2005-05-19 Britt Shawn D. Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US20050137140A1 (en) * 2003-10-10 2005-06-23 Cottrell Kevin M. Inhibitors of serine proteases, particularly HCV NS3-NS4A proteases
US20050267043A1 (en) * 2004-02-27 2005-12-01 Schering Corporation Novel inhibitors of hepatitis C virus NS3 protease
WO2006017295A2 (en) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
WO2007025307A2 (en) * 2005-08-26 2007-03-01 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOGEN STÉPHANE L ET AL: "Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.", JOURNAL OF MEDICINAL CHEMISTRY 4 MAY 2006, vol. 49, no. 9, 5 April 2006 (2006-04-05), pages 2750 - 2757, XP002477384, ISSN: 0022-2623 *
MALCOLM B A ET AL: "SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 50, no. 3, March 2006 (2006-03-01), pages 1013 - 1020, XP002451894, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
UA100666C2 (en) 2013-01-25
CR10336A (en) 2008-12-03
RU2448976C2 (en) 2012-04-27
IL194434A0 (en) 2011-08-01
KR101059593B1 (en) 2011-08-25
MA30392B1 (en) 2009-05-04
SG173368A1 (en) 2011-08-29
TWI341207B (en) 2011-05-01
EP2518079A2 (en) 2012-10-31
EP2007789A2 (en) 2008-12-31
US8211932B2 (en) 2012-07-03
MY147247A (en) 2012-11-14
HK1126798A1 (en) 2009-09-11
MX2008013119A (en) 2008-10-21
WO2007133865A2 (en) 2007-11-22
US20070286842A1 (en) 2007-12-13
PE20121157A1 (en) 2012-09-14
AU2007249668B2 (en) 2011-04-07
US20130149281A1 (en) 2013-06-13
KR20080111123A (en) 2008-12-22
NZ571826A (en) 2012-01-12
BRPI0710878A2 (en) 2015-03-31
ECSP088811A (en) 2008-11-27
TW200815478A (en) 2008-04-01
AU2007249668A1 (en) 2007-11-22
CL2007001005A1 (en) 2008-07-11
EP2007789B1 (en) 2015-05-20
CN101466727B (en) 2012-10-17
CN101466727A (en) 2009-06-24
CA2643680A1 (en) 2007-11-22
US20100331243A1 (en) 2010-12-30
ES2543840T3 (en) 2015-08-24
JP2009533464A (en) 2009-09-17
US8445527B2 (en) 2013-05-21
JP5167244B2 (en) 2013-03-21
AR060405A1 (en) 2008-06-11
US20120231998A1 (en) 2012-09-13
PE20080072A1 (en) 2008-03-28
EP2518079A3 (en) 2012-12-12
NO20084749L (en) 2008-11-10
RU2008144299A (en) 2010-05-20
TNSN08400A1 (en) 2010-04-14
US7825152B2 (en) 2010-11-02

Similar Documents

Publication Publication Date Title
WO2007133865A3 (en) Hcv/hiv inhibitors an their uses
MX2009006536A (en) Organic compounds and their uses.
TN2010000137A1 (en) Spiropyrrolidines and their use against hcv and hiv infection
MX2009006535A (en) Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors.
WO2007121125A3 (en) Hcv inhibitors
TN2011000482A1 (en) Organic compounds and their uses
WO2008033562A3 (en) Kinase inhibitor compounds
WO2009152356A3 (en) Compounds and compositions useful for the treatment of malaria
WO2009156462A3 (en) Organic compounds
WO2007121124A3 (en) Hcv inhibitors comprising beta amino acids and their uses
WO2007120595A3 (en) Amines for the treatment of hcv
WO2008127364A3 (en) Antiviral compounds and use thereof
WO2008051477A3 (en) Hcv ns3 protease inhibitors
WO2008057208A3 (en) Hcv ns3 protease inhibitors
WO2008051514A3 (en) Hcv ns3 protease inhibitors
WO2008051475A3 (en) Hcv ns3 protease inhibitors
WO2007115821A3 (en) Organic compounds
WO2008149353A3 (en) Telomerase activating compounds and methods of use thereof
WO2008133734A3 (en) Method and compositions for treating hiv infections
WO2007109105A3 (en) Flavivirus inhibition by sultams and related compounds
WO2008073332A3 (en) Creatine compositions for skin treatment
UA95103C2 (en) Substituted arylsulfonamides as antiviral agents
TNSN08496A1 (en) Aminothiazoles and their uses
WO2008008700A3 (en) Substituted cyclopentane derivatives as therapeutic agents
WO2007112121A3 (en) Tetracycline compounds and methods of treatment

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780021354.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07811837

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2007249668

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 194434

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: CR2008-010336

Country of ref document: CR

WWE Wipo information: entry into national phase

Ref document number: 2007811837

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 8332/DELNP/2008

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2643680

Country of ref document: CA

Ref document number: 571826

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: MX/a/2008/013119

Country of ref document: MX

Ref document number: 2009505555

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2008101675

Country of ref document: EG

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2007249668

Country of ref document: AU

Date of ref document: 20070409

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: DZP2008000655

Country of ref document: DZ

WWE Wipo information: entry into national phase

Ref document number: 1020087027485

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2008144299

Country of ref document: RU

ENP Entry into the national phase

Ref document number: PI0710878

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20081010