WO2007137071A3 - Compositions of r(+) and s(-) pramipexole and methods of using the same - Google Patents

Compositions of r(+) and s(-) pramipexole and methods of using the same Download PDF

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Publication number
WO2007137071A3
WO2007137071A3 PCT/US2007/069044 US2007069044W WO2007137071A3 WO 2007137071 A3 WO2007137071 A3 WO 2007137071A3 US 2007069044 W US2007069044 W US 2007069044W WO 2007137071 A3 WO2007137071 A3 WO 2007137071A3
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WO
WIPO (PCT)
Prior art keywords
pramipexole
compositions
methods
same
parkinson
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/069044
Other languages
French (fr)
Other versions
WO2007137071A2 (en
Inventor
Michael E Bozik
Thomas Petzinger Jr
Valentin Gribkoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Knopp Neurosciences Inc
Original Assignee
Knopp Neurosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/733,642 external-priority patent/US20070259930A1/en
Priority to EP07797504A priority Critical patent/EP2026803B1/en
Application filed by Knopp Neurosciences Inc filed Critical Knopp Neurosciences Inc
Priority to JP2009511221A priority patent/JP2009537565A/en
Priority to DK07797504.3T priority patent/DK2026803T3/en
Priority to CN2007800179185A priority patent/CN101448498B/en
Priority to ES07797504T priority patent/ES2379117T3/en
Priority to PL07797504T priority patent/PL2026803T3/en
Priority to AT07797504T priority patent/ATE537826T1/en
Priority to AU2007253899A priority patent/AU2007253899A1/en
Priority to CA002652251A priority patent/CA2652251A1/en
Publication of WO2007137071A2 publication Critical patent/WO2007137071A2/en
Publication of WO2007137071A3 publication Critical patent/WO2007137071A3/en
Priority to IL195256A priority patent/IL195256A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Tires In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Compositions of predetermined amounts of R(+) pramipexole and S(-) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided.
PCT/US2007/069044 2006-05-16 2007-05-16 Compositions of r(+) and s(-) pramipexole and methods of using the same Ceased WO2007137071A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AT07797504T ATE537826T1 (en) 2006-05-16 2007-05-16 COMPOSITIONS OF R(+)- AND S(-)-PRAMIPEXOLE AND METHOD FOR THEIR USE
PL07797504T PL2026803T3 (en) 2006-05-16 2007-05-16 Compositions of r(+) and s(-) pramipexole and methods of using the same
JP2009511221A JP2009537565A (en) 2006-05-16 2007-05-16 R (+) and S (-) pramipexole compositions and methods of using the same
DK07797504.3T DK2026803T3 (en) 2006-05-16 2007-05-16 Compositions of R (+) and S (-) pramipexole and methods for their use
CN2007800179185A CN101448498B (en) 2006-05-16 2007-05-16 Compositions of R(+) and S(-) pramipexole and methods of using same
ES07797504T ES2379117T3 (en) 2006-05-16 2007-05-16 Compositions of R (+) and S (-) pramipexole and methods of use thereof
AU2007253899A AU2007253899A1 (en) 2006-05-16 2007-05-16 Compositions of R(+) and S(-) pramipexole and methods of using the same
EP07797504A EP2026803B1 (en) 2006-05-16 2007-05-16 Compositions of r(+) and s(-) pramipexole and methods of using the same
CA002652251A CA2652251A1 (en) 2006-05-16 2007-05-16 Compositions of r(+) and s(-) pramipexole and methods for using the same
IL195256A IL195256A0 (en) 2006-05-16 2008-11-12 Compositions of r(+)and s(-)pramipexole and methods of using the same

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US74732006P 2006-05-16 2006-05-16
US60/747,320 2006-05-16
US87000906P 2006-12-14 2006-12-14
US60/870,009 2006-12-14
US89483507P 2007-03-14 2007-03-14
US89482907P 2007-03-14 2007-03-14
US89479907P 2007-03-14 2007-03-14
US60/894,829 2007-03-14
US60/894,835 2007-03-14
US60/894,799 2007-03-14
US11/733,642 US20070259930A1 (en) 2006-04-10 2007-04-10 Compositions and methods of using r(+) pramipexole
US11/733,642 2007-04-10

Publications (2)

Publication Number Publication Date
WO2007137071A2 WO2007137071A2 (en) 2007-11-29
WO2007137071A3 true WO2007137071A3 (en) 2008-04-17

Family

ID=40134109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069044 Ceased WO2007137071A2 (en) 2006-05-16 2007-05-16 Compositions of r(+) and s(-) pramipexole and methods of using the same

Country Status (13)

Country Link
US (3) US8017598B2 (en)
EP (1) EP2026803B1 (en)
JP (1) JP2009537565A (en)
KR (1) KR20090021169A (en)
CN (2) CN102160865A (en)
AT (1) ATE537826T1 (en)
AU (1) AU2007253899A1 (en)
CA (1) CA2652251A1 (en)
DK (1) DK2026803T3 (en)
ES (1) ES2379117T3 (en)
IL (1) IL195256A0 (en)
PL (1) PL2026803T3 (en)
WO (1) WO2007137071A2 (en)

Families Citing this family (25)

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US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
ATE537826T1 (en) 2006-05-16 2012-01-15 Knopp Neurosciences Inc COMPOSITIONS OF R(+)- AND S(-)-PRAMIPEXOLE AND METHOD FOR THEIR USE
EP2465500A1 (en) * 2006-05-16 2012-06-20 Knopp Neurosciences, Inc. Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of parkinson's disease
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
EP2136638A4 (en) * 2007-03-14 2010-05-12 Knopp Neurosciences Inc Modified release formulations of (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (en) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． Synthesis of chiral purified substituted benzothiazolediamine
WO2009109990A2 (en) * 2008-01-24 2009-09-11 Sun Pharmaceutical Industries Ltd. Pharmaceutical composition of pramipexole
US8969417B2 (en) 2008-06-06 2015-03-03 Pharmatwob Ltd. Pharmaceutical compositions for treatment of Parkinsons disease
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
AU2010234244A1 (en) * 2009-04-09 2011-10-13 Purdue Pharma Once-daily oral IR/CR pramipexole formulation
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
US20120059013A1 (en) * 2010-03-09 2012-03-08 Boehringer Ingelheim International Gmbh Method of treating early morning akinesia in subjects having parkinson's disease
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
PL3019167T3 (en) 2013-07-12 2021-06-14 Knopp Biosciences Llc Treatment of elevated levels of eosinophils and / or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
DK3033081T3 (en) 2013-08-13 2021-05-31 Knopp Biosciences Llc Compositions and methods of treatment of chronic urticaria
EP3038467B1 (en) 2013-08-13 2020-07-29 Knopp Biosciences LLC Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
EP2870965A1 (en) * 2013-11-06 2015-05-13 Sanovel Ilac Sanayi ve Ticaret A.S. Oral liquid pharmaceutical formulations of pramipexole
IL269550B2 (en) * 2017-03-27 2025-01-01 Chase Therapeutics Corp A combination of a 5ht3-antagonist and pramipexole for treating synucleinopathies
IL312486B2 (en) 2017-04-10 2025-05-01 Chase Therapeutics Corp Nk1-antagonist combination and method for treating synucleinopathies
US11318122B2 (en) 2017-04-13 2022-05-03 Chase Therapeutics Corporation Pharmaceutical combination and its use for treating synucleinopathties
CN111588692B (en) * 2020-05-23 2022-11-22 常州市第四制药厂有限公司 Pramipexole dihydrochloride oral solution
CN115260119B (en) * 2022-07-26 2023-02-10 山东京卫制药有限公司 A kind of pramipexole xinafoate and drug sustained-release preparation thereof

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