WO2007147505A3 - A system for controlling administration of anaesthesia - Google Patents

A system for controlling administration of anaesthesia Download PDF

Info

Publication number
WO2007147505A3
WO2007147505A3 PCT/EP2007/005165 EP2007005165W WO2007147505A3 WO 2007147505 A3 WO2007147505 A3 WO 2007147505A3 EP 2007005165 W EP2007005165 W EP 2007005165W WO 2007147505 A3 WO2007147505 A3 WO 2007147505A3
Authority
WO
WIPO (PCT)
Prior art keywords
patient
respiratory
drugs
mixture
delivery unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/005165
Other languages
French (fr)
Other versions
WO2007147505A2 (en
Inventor
Thomas Bouillon
Antonello Caruso
Martin Luginbuehl
Manfred Morari
Peter Matthias Schumacher
Eleonora Zanderigo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Bern
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Bern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ, Universitaet Bern filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Priority to US12/305,806 priority Critical patent/US20100212666A1/en
Priority to EP07725978A priority patent/EP2029197A2/en
Priority to JP2009515741A priority patent/JP2009540890A/en
Publication of WO2007147505A2 publication Critical patent/WO2007147505A2/en
Publication of WO2007147505A3 publication Critical patent/WO2007147505A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M19/00—Local anaesthesia; Hypothermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4821—Determining level or depth of anaesthesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/048—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/202—Blood composition characteristics partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/208—Blood composition characteristics pH-value
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/43—Composition of exhalation
    • A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A system for controlling administration of a respiratory depressant drug or mixture of drugs to a spontaneously breathing patient comprises a drug delivery unit (3), being adapted for indexed or continuous and automatic titration of a respiratory depressant drug or mixture of such drugs to said patient (1), and a control apparatus (6), receiving measurement signals (20) relative to the respiratory state of said patient (1) and issuing control signals (27) to said drug delivery unit (3), wherein the control apparatus is adapted to keep said measurement signals relative to the respiratory state to a predetermined condition and thereby providing adequate sedation and/or analgesia to said patient.
PCT/EP2007/005165 2006-06-21 2007-06-12 A system for controlling administration of anaesthesia Ceased WO2007147505A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/305,806 US20100212666A1 (en) 2006-06-21 2007-06-12 System for Controlling Administration of Anaesthesia
EP07725978A EP2029197A2 (en) 2006-06-21 2007-06-12 A system for controlling administration of anaesthesia
JP2009515741A JP2009540890A (en) 2006-06-21 2007-06-12 System for controlling anesthetic administration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06012702.4 2006-06-21
EP06012702 2006-06-21

Publications (2)

Publication Number Publication Date
WO2007147505A2 WO2007147505A2 (en) 2007-12-27
WO2007147505A3 true WO2007147505A3 (en) 2008-04-17

Family

ID=38474335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/005165 Ceased WO2007147505A2 (en) 2006-06-21 2007-06-12 A system for controlling administration of anaesthesia

Country Status (4)

Country Link
EP (1) EP2029197A2 (en)
JP (1) JP2009540890A (en)
CN (1) CN101472631A (en)
WO (1) WO2007147505A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946209B2 (en) 2009-04-28 2015-02-03 Optmed, Inc. Compositions and methods for treating and preventing urolithiasis and conditions associated therewith
US20130150748A1 (en) * 2010-07-23 2013-06-13 Quantium Medical S.L. Apparatus for combining drug effect interaction between anaesthetics and analgesics and electroencephalogram features for precise assessment of the level of consciousness during anaesthesia
AU2011289159C1 (en) * 2010-08-13 2015-12-10 Respiratory Motion, Inc. Devices and methods for respiratory variation monitoring by measurement of respiratory volumes, motion and variability
US11723542B2 (en) 2010-08-13 2023-08-15 Respiratory Motion, Inc. Advanced respiratory monitor and system
US10702166B1 (en) 2010-08-13 2020-07-07 Respiratory Motion, Inc. Devices and methods for respiratory variation monitoring by measurement of respiratory volumes, motion and variability
US20120192862A1 (en) * 2011-01-31 2012-08-02 Carefusion 303, Inc. Patient-controlled aerosol administration
WO2013013153A1 (en) 2011-07-20 2013-01-24 Respiratory Motion, Inc. Impedance measuring devices and methods for emergency cardiovascular care
DE102012009617B4 (en) 2012-05-15 2020-03-26 Drägerwerk AG & Co. KGaA Data processing device for an anesthesia device
CA2883623C (en) 2012-09-07 2020-06-23 Respiratory Motion, Inc. Electrode padset
US12343130B2 (en) 2012-09-07 2025-07-01 Respiratory Motion, Inc. Spacing of electrodes for bioimpedance measurements
EP2742964A1 (en) * 2012-12-11 2014-06-18 General Electric Company Apparatus and method for supplying anesthetic agent and anesthesia system for providing inspiration gas to lungs of a subject
US10388405B2 (en) 2013-03-22 2019-08-20 Massachusetts Institute Of Technology Systems and methods for predicting adverse events and assessing level of sedation during medical procedures
WO2014173558A1 (en) * 2013-04-24 2014-10-30 Fresenius Kabi Deutschland Gmbh Method of operating a control device for controlling an infusion device
EP2799009A1 (en) * 2013-04-29 2014-11-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-invasive method for prediction of opioid-analgesia and opioid-blood-concentrations
US20150032053A1 (en) 2013-07-29 2015-01-29 Medtronic, Inc. Titration for medical infusion devices and systems
EP3114672B1 (en) 2014-03-06 2020-06-24 Respiratory Motion, Inc. Methods and devices for displaying trend and variability in a physiological dataset
WO2016073604A1 (en) 2014-11-04 2016-05-12 Respiratory Motion, Inc. Respiratory parameter guided automated iv administration and iv tube clamp activation
EP3236956A1 (en) 2014-12-23 2017-11-01 Bosteels, Arnaud Combination of remifentanil and propofol
WO2017027855A1 (en) * 2015-08-12 2017-02-16 Massachusetts Institute Of Technology Systems and methods for predicting adverse events and assessing level of sedation during medical procedures
DE102015015441A1 (en) * 2015-12-02 2017-06-08 Drägerwerk AG & Co. KGaA Anesthesia ventilation device for automated ventilation and for detecting an operating state with regard to automated ventilation
WO2017106500A1 (en) 2015-12-15 2017-06-22 Respiratory Motion, Inc. Evaluation of respiratory volume monitoring to detect respiratory compromise before pulse oximetry and eliminate false desaturation alarms
WO2017136340A1 (en) * 2016-02-02 2017-08-10 Mallinckrodt Hospital Products IP Limited Compensating for disruptions in breathing gas flow measurement
EP3742959A1 (en) * 2018-01-26 2020-12-02 Universite d'Aix-Marseille (AMU) A method for measuring a sedation state of a patient
US12605122B2 (en) 2019-06-07 2026-04-21 Respiratory Motion, Inc. Device and method for clinical evaluation
US12251535B2 (en) 2020-04-20 2025-03-18 Fresenius Kabi Usa, Llc Fluid pump notification and control based on monitored feedback
DE102020129891A1 (en) * 2020-11-12 2022-05-12 Drägerwerk AG & Co. KGaA Apparatus, system comprising the apparatus, method and computer program for controlling the administration of a medicament to a patient
CN114768014B (en) * 2022-04-02 2023-06-27 广州蓝仕威克医疗科技有限公司 Regulating and controlling system and method based on carbon dioxide artery and end-tidal carbon dioxide partial pressure
CN116236649B (en) * 2022-12-21 2025-08-01 北京谊安医疗系统股份有限公司 Target drug concentration estimation method and system for inhalation anesthesia

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041770A1 (en) * 2000-11-23 2002-05-30 Sentec Ag Sensor and method for measuring physiological parameters
WO2004000400A2 (en) * 2002-06-24 2003-12-31 University Of Florida Method and apparatus for monitoring respiratory gases during anesthesia
FR2858237A1 (en) * 2003-08-01 2005-02-04 Draegerwerk Ag SYSTEM FOR MEASURING PROPOFOL CONCENTRATION IN A BREATHING GAS CURRENT
US20050054942A1 (en) * 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
US20050092322A1 (en) * 2003-11-05 2005-05-05 Collins William L.Jr. Cannula assembly and medical system employing a known carbon dioxide gas concentration
WO2005082369A1 (en) * 2003-02-28 2005-09-09 Delex Therapeutics Inc. Opioid delivery system
WO2005110221A1 (en) * 2004-05-18 2005-11-24 Linde Medical Sensors Ag Process for measuring partial transcutaneous co2 pressure at an ear lobe
WO2006133825A1 (en) * 2005-06-17 2006-12-21 Bayer Technology Services Gmbh Device for the time-controlled intravenous administering of the anesthetic propofol

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041770A1 (en) * 2000-11-23 2002-05-30 Sentec Ag Sensor and method for measuring physiological parameters
US20050054942A1 (en) * 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
WO2004000400A2 (en) * 2002-06-24 2003-12-31 University Of Florida Method and apparatus for monitoring respiratory gases during anesthesia
WO2005082369A1 (en) * 2003-02-28 2005-09-09 Delex Therapeutics Inc. Opioid delivery system
FR2858237A1 (en) * 2003-08-01 2005-02-04 Draegerwerk Ag SYSTEM FOR MEASURING PROPOFOL CONCENTRATION IN A BREATHING GAS CURRENT
US20050092322A1 (en) * 2003-11-05 2005-05-05 Collins William L.Jr. Cannula assembly and medical system employing a known carbon dioxide gas concentration
WO2005110221A1 (en) * 2004-05-18 2005-11-24 Linde Medical Sensors Ag Process for measuring partial transcutaneous co2 pressure at an ear lobe
WO2006133825A1 (en) * 2005-06-17 2006-12-21 Bayer Technology Services Gmbh Device for the time-controlled intravenous administering of the anesthetic propofol

Also Published As

Publication number Publication date
EP2029197A2 (en) 2009-03-04
WO2007147505A2 (en) 2007-12-27
JP2009540890A (en) 2009-11-26
CN101472631A (en) 2009-07-01

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