WO2007149486A3 - Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components - Google Patents

Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components Download PDF

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Publication number
WO2007149486A3
WO2007149486A3 PCT/US2007/014382 US2007014382W WO2007149486A3 WO 2007149486 A3 WO2007149486 A3 WO 2007149486A3 US 2007014382 W US2007014382 W US 2007014382W WO 2007149486 A3 WO2007149486 A3 WO 2007149486A3
Authority
WO
WIPO (PCT)
Prior art keywords
materials
clathrin
methods
apoptosis
pathway components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/014382
Other languages
French (fr)
Other versions
WO2007149486A2 (en
Inventor
Cary D Austin
David A Lawrence
Avi Ashkenazi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/308,542 priority Critical patent/US8198033B2/en
Priority to BRPI0712629A priority patent/BRPI0712629C1/en
Priority to CA2655460A priority patent/CA2655460C/en
Priority to MX2008016170A priority patent/MX2008016170A/en
Priority to EP07809716.9A priority patent/EP2044434B1/en
Priority to JP2009516559A priority patent/JP5222845B2/en
Priority to CN200780030709.4A priority patent/CN101535805B/en
Priority to AU2007261405A priority patent/AU2007261405B2/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to NZ574009A priority patent/NZ574009A/en
Priority to KR1020097001055A priority patent/KR101433971B1/en
Publication of WO2007149486A2 publication Critical patent/WO2007149486A2/en
Publication of WO2007149486A3 publication Critical patent/WO2007149486A3/en
Priority to IL195973A priority patent/IL195973A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.
PCT/US2007/014382 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components Ceased WO2007149486A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CN200780030709.4A CN101535805B (en) 2006-06-20 2007-06-20 Methods and materials for visualization of apoptosis by detecting fragments of clathrin pathway components
CA2655460A CA2655460C (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis
MX2008016170A MX2008016170A (en) 2006-06-20 2007-06-20 METHODS AND MATERIALS TO OBSERVE APOPTOSIS.
EP07809716.9A EP2044434B1 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components
JP2009516559A JP5222845B2 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis
AU2007261405A AU2007261405B2 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components
NZ574009A NZ574009A (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components
US12/308,542 US8198033B2 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis
BRPI0712629A BRPI0712629C1 (en) 2006-06-20 2007-06-20 method for detecting apoptosis and method for identifying a human cancer cell
KR1020097001055A KR101433971B1 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components
IL195973A IL195973A (en) 2006-06-20 2008-12-16 Methods and materials for observing apoptosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81495506P 2006-06-20 2006-06-20
US60/814,955 2006-06-20

Publications (2)

Publication Number Publication Date
WO2007149486A2 WO2007149486A2 (en) 2007-12-27
WO2007149486A3 true WO2007149486A3 (en) 2008-03-20

Family

ID=38834096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/014382 Ceased WO2007149486A2 (en) 2006-06-20 2007-06-20 Methods and materials for observing apoptosis by detecting fragments of clathrin-pathway components

Country Status (14)

Country Link
US (1) US8198033B2 (en)
EP (1) EP2044434B1 (en)
JP (1) JP5222845B2 (en)
KR (1) KR101433971B1 (en)
CN (1) CN101535805B (en)
AU (1) AU2007261405B2 (en)
BR (1) BRPI0712629C1 (en)
CA (1) CA2655460C (en)
IL (1) IL195973A (en)
MX (1) MX2008016170A (en)
NZ (1) NZ574009A (en)
RU (1) RU2450273C2 (en)
WO (1) WO2007149486A2 (en)
ZA (1) ZA200900043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5133842B2 (en) * 2008-10-14 2013-01-30 国立大学法人 千葉大学 Method for discriminating between cancerous part and non-cancerous part of patient suspected of cancer or tissue derived from cancer patient, and discrimination reagent used therefor
RU2508542C1 (en) * 2012-07-16 2014-02-27 Полина Михайловна Шварцбурд Rapid method for determining risk of cell malignancy
WO2015138638A1 (en) 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
EA201892260A1 (en) 2016-04-07 2019-03-29 Дзе Джонс Хопкинс Юниверсити COMPOSITIONS AND METHODS FOR THE TREATMENT OF PANCREATITIS AND PAIN WITH THE APPLICATION OF THE AGONISTS OF THE DEATH RECEPTOR
GB201615842D0 (en) * 2016-09-16 2016-11-02 Ucl Business Plc Cell death biomarker

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017648A1 (en) * 1998-09-24 2000-03-30 Promega Corporation Apoptosis marker antibodies and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935801A (en) * 1996-03-29 1999-08-10 Dana-Farber Cancer Institute Monoclonal antibody that detects apoptotic antigen
EP1077724A2 (en) * 1998-04-17 2001-02-28 The University Of Vermont Methods and products related to metabolic interactions in disease
EP1344831A4 (en) * 2000-12-22 2004-06-16 Chugai Pharmaceutical Co Ltd METHOD FOR MEASURING THE CELL DEATH OF TARGETED CELLS
US6797677B2 (en) 2002-05-30 2004-09-28 Afton Chemical Corporation Antioxidant combination for oxidation and deposit control in lubricants containing molybdenum and alkylated phenothiazine
US20060019256A1 (en) * 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017648A1 (en) * 1998-09-24 2000-03-30 Promega Corporation Apoptosis marker antibodies and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AUSTIN CARY D ET AL: "Death-receptor activation halts clathrin-dependent endocytosis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 5 JUL 2006, vol. 103, no. 27, 5 July 2006 (2006-07-05), pages 10283 - 10288, XP002464806, ISSN: 0027-8424 *
ENARI MASATO ET AL: "Requirement of clathrin heavy chain for p53-mediated transcription", GENES & DEVELOPMENT, vol. 20, no. 9, May 2006 (2006-05-01), pages 1087 - 1099, XP002464807, ISSN: 0890-9369 *
HANSEN B ET AL: "Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 303, no. 1, 1 February 2005 (2005-02-01), pages 160 - 173, XP004657342, ISSN: 0014-4827 *
WETTEY FRANK R ET AL: "Controlled elimination of clathrin heavy-chain expression in DT40 lymphocytes.", SCIENCE (NEW YORK, N.Y.) 30 AUG 2002, vol. 297, no. 5586, 30 August 2002 (2002-08-30), pages 1521 - 1525, XP002464805, ISSN: 1095-9203 *

Also Published As

Publication number Publication date
RU2450273C2 (en) 2012-05-10
WO2007149486A2 (en) 2007-12-27
US20110244473A1 (en) 2011-10-06
MX2008016170A (en) 2009-02-03
CN101535805B (en) 2014-02-12
EP2044434B1 (en) 2015-11-18
RU2009101512A (en) 2010-07-27
CA2655460A1 (en) 2007-12-27
IL195973A (en) 2011-05-31
BRPI0712629C1 (en) 2021-07-27
KR20090024795A (en) 2009-03-09
AU2007261405B2 (en) 2013-02-14
CN101535805A (en) 2009-09-16
NZ574009A (en) 2012-01-12
BRPI0712629A2 (en) 2012-10-23
JP2009541741A (en) 2009-11-26
EP2044434A2 (en) 2009-04-08
AU2007261405A1 (en) 2007-12-27
US8198033B2 (en) 2012-06-12
BRPI0712629B1 (en) 2018-07-17
JP5222845B2 (en) 2013-06-26
ZA200900043B (en) 2010-03-31
KR101433971B1 (en) 2014-08-25
IL195973A0 (en) 2009-09-01
CA2655460C (en) 2014-05-20
BRPI0712629B8 (en) 2018-09-25

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