WO2008008826A3 - Methods and apparatus for the ion mobility based separation and collection of molecules - Google Patents

Methods and apparatus for the ion mobility based separation and collection of molecules Download PDF

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Publication number
WO2008008826A3
WO2008008826A3 PCT/US2007/073244 US2007073244W WO2008008826A3 WO 2008008826 A3 WO2008008826 A3 WO 2008008826A3 US 2007073244 W US2007073244 W US 2007073244W WO 2008008826 A3 WO2008008826 A3 WO 2008008826A3
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WO
WIPO (PCT)
Prior art keywords
ion mobility
interest
collection
mobility separator
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/073244
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French (fr)
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WO2008008826A2 (en
WO2008008826A9 (en
Inventor
Ching Wu
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Excellims Corp
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Excellims Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Excellims Corp filed Critical Excellims Corp
Priority to EP07799479A priority Critical patent/EP2040824A2/en
Priority to CA002659830A priority patent/CA2659830A1/en
Publication of WO2008008826A2 publication Critical patent/WO2008008826A2/en
Publication of WO2008008826A3 publication Critical patent/WO2008008826A3/en
Publication of WO2008008826A9 publication Critical patent/WO2008008826A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

This invention describes an apparatus for the separation and collection of components in a sample of interest comprising: an ionization source; an ion mobility separator and an ion collector positioned to receive ions leaving the ion mobility separator. The ion mobility separator having an inlet to supply at least one separating substance which comprises particles which selectively interact with at least one analyte component of interest to certain degree different from the others. The analyte component of interest may be enantiomers, diastereomers, stereoisomers, isomers, etc. The ion collector can be used to conduct analytical, preparative, and semi-preparative separation. In addition, a combined primary electrospray and secondary electrospray ionization source is disclosed to enhance ionization efficiency of interest.
PCT/US2007/073244 2006-07-11 2007-07-11 Methods and apparatus for the ion mobility based separation and collection of molecules Ceased WO2008008826A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07799479A EP2040824A2 (en) 2006-07-11 2007-07-11 Methods and apparatus for the ion mobility based separation and collection of molecules
CA002659830A CA2659830A1 (en) 2006-07-11 2007-07-11 Methods and apparatus for the ion mobility based separation and collection of molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80703106P 2006-07-11 2006-07-11
US60/807,031 2006-07-11
US89153207P 2007-02-26 2007-02-26
US60/891,532 2007-02-26

Publications (3)

Publication Number Publication Date
WO2008008826A2 WO2008008826A2 (en) 2008-01-17
WO2008008826A3 true WO2008008826A3 (en) 2008-05-02
WO2008008826A9 WO2008008826A9 (en) 2008-06-05

Family

ID=38924137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/073244 Ceased WO2008008826A2 (en) 2006-07-11 2007-07-11 Methods and apparatus for the ion mobility based separation and collection of molecules

Country Status (4)

Country Link
US (2) US20080173809A1 (en)
EP (1) EP2040824A2 (en)
CA (1) CA2659830A1 (en)
WO (1) WO2008008826A2 (en)

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CN101999156B (en) * 2008-04-03 2013-01-23 环境学有限公司 Method for measuring gases and corresponding ion mobility spectrometer

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Also Published As

Publication number Publication date
US9257269B2 (en) 2016-02-09
WO2008008826A2 (en) 2008-01-17
CA2659830A1 (en) 2008-01-17
US20080173809A1 (en) 2008-07-24
WO2008008826A9 (en) 2008-06-05
EP2040824A2 (en) 2009-04-01
US20130037710A1 (en) 2013-02-14

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