WO2008012440A3 - Composes pyridaziniques et pyrroliques, procedes d'obtention et applications - Google Patents

Composes pyridaziniques et pyrroliques, procedes d'obtention et applications Download PDF

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Publication number
WO2008012440A3
WO2008012440A3 PCT/FR2007/001287 FR2007001287W WO2008012440A3 WO 2008012440 A3 WO2008012440 A3 WO 2008012440A3 FR 2007001287 W FR2007001287 W FR 2007001287W WO 2008012440 A3 WO2008012440 A3 WO 2008012440A3
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WO
WIPO (PCT)
Prior art keywords
obtaining
processes
pyridazine
pyrrole compounds
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/001287
Other languages
English (en)
Other versions
WO2008012440A2 (fr
Inventor
Didier Max Dubreuil
Muriel Genevieve Pipelier
Jean Paul Pradere
Hicham Bakkali
Patrice Lepape
Thierry Delaunay
Alexandra Tabatchnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to US12/309,585 priority Critical patent/US9034873B2/en
Priority to CA002658624A priority patent/CA2658624A1/fr
Priority to JP2009521300A priority patent/JP5564252B2/ja
Priority to EP07823344A priority patent/EP2069345A2/fr
Publication of WO2008012440A2 publication Critical patent/WO2008012440A2/fr
Publication of WO2008012440A3 publication Critical patent/WO2008012440A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/10—Metal complexes of organic compounds not being dyes in uncomplexed form

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

La présente invention est relative à des composés oligopyridaziniques non linéaires, à leurs procédés d'obtention, à leurs applications, ainsi qu'à leur régression en oligopyrroles et aux applications des composés pyridazinyl-pyrroliques et oligopyrroliques obtenus. L'invention vise en particulier les applications en tant que médicaments, notamment pour traiter des pathologies telles que le cancer, les infections bactériennes ou parasitaires, ainsi que les applications dans le domaine des matériaux, de l'environnement de l'électronique et de l'optique.
PCT/FR2007/001287 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications Ceased WO2008012440A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/309,585 US9034873B2 (en) 2006-07-26 2007-07-26 Pyridazine and pyrrole compounds, processes for obtaining them and uses
CA002658624A CA2658624A1 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications
JP2009521300A JP5564252B2 (ja) 2006-07-26 2007-07-26 ピリダジンおよびピロール化合物、それらを得るための方法および使用
EP07823344A EP2069345A2 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606842 2006-07-26
FR0606842A FR2904315B1 (fr) 2006-07-26 2006-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications

Publications (2)

Publication Number Publication Date
WO2008012440A2 WO2008012440A2 (fr) 2008-01-31
WO2008012440A3 true WO2008012440A3 (fr) 2008-05-29

Family

ID=37763892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001287 Ceased WO2008012440A2 (fr) 2006-07-26 2007-07-26 Composes pyridaziniques et pyrroliques, procedes d'obtention et applications

Country Status (6)

Country Link
US (1) US9034873B2 (fr)
EP (1) EP2069345A2 (fr)
JP (1) JP5564252B2 (fr)
CA (1) CA2658624A1 (fr)
FR (1) FR2904315B1 (fr)
WO (1) WO2008012440A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2186810A1 (fr) 2008-10-31 2010-05-19 Institut Curie Dérivés de poly-hétéroaryle pour le traitement de cancer
WO2010088268A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Matériaux à libération contrôlée déclenchée de façon exogène et leurs utilisations
WO2010088286A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugués synthétiques et leurs utilisations
WO2010088300A1 (fr) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugués d'insuline cristalline
BRPI1007457A2 (pt) 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
WO2010107520A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués d'insulines non déposées solubles et leurs utilisations
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
KR20120102649A (ko) 2009-10-30 2012-09-18 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 질소 함유 방향족 화합물 및 금속 착체
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
EP2598522A4 (fr) 2010-07-28 2014-11-12 Smartcells Inc Lectines recombinées, lectines à site de liaison modifié et leurs utilisations
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP2014156402A (ja) * 2011-05-27 2014-08-28 Nippon Soda Co Ltd ビピリジン化合物および殺菌剤
WO2013033018A2 (fr) 2011-08-30 2013-03-07 Drexel University Complexes de dihydroxybipyridine de ruthénium et d'iridium destinés à l'oxydation de l'eau et à l'hydrogénation
US20150174034A1 (en) 2013-03-13 2015-06-25 Avon Products, Inc. Tyrosinase inhibitors
US9364405B2 (en) 2013-03-13 2016-06-14 Avon Products, Inc. Tyrosinase inhibitors
WO2014158943A1 (fr) * 2013-03-13 2014-10-02 Avon Products, Inc Inhibiteurs de tyrosinase
KR20160065930A (ko) 2013-10-04 2016-06-09 머크 샤프 앤드 돔 코포레이션 글루코스-반응성 인슐린 접합체
US10130625B2 (en) 2014-07-22 2018-11-20 University Of Maryland, College Park Linked diaryl compounds with anticancer properties and methods of using the same
EP3684364A4 (fr) 2017-09-18 2021-06-02 Goldfinch Bio, Inc. Pyridazinones et leurs procédés d'utilisation
JP7063231B2 (ja) * 2018-10-26 2022-05-09 住友化学株式会社 ジピリダジニルエーテル化合物及びその用途
CN110437206B (zh) * 2019-03-13 2022-06-10 上海大学 吡啶-吡咯交替的分子折叠体及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20040186288A1 (en) * 2001-05-08 2004-09-23 Martin Kruger 3,5-Diamino-1,2,4-triazoles as kinase inhibitors

Family Cites Families (1)

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JP3889065B2 (ja) * 1994-03-15 2007-03-07 株式会社東芝 有機非線形光学材料

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186288A1 (en) * 2001-05-08 2004-09-23 Martin Kruger 3,5-Diamino-1,2,4-triazoles as kinase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAXTER P N ET AL: "Self-assembly and structure of interconverting multinuclear inorganic arrays: a [4X5]-Ag(I)20 grid and an Ag(I)10 quadruple helicate", CHEMISTRY - A EUROPEAN JOURNAL, vol. 6, no. 24, 15 December 2000 (2000-12-15), pages 4510 - 4517, XP002422690 *
COATES W J ET AL: "1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl) benzene analogs: potent phosphodiesterase inhibitors and inodilators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 6, 1990, pages 1735 - 1741, XP002119282 *
JONES R A ET AL: "Extended heterocyclic systems 1. The synthesis and characterisation of pyrrolylpyridines, alternating pyrrole:pyridine oligomers and polymers, and related systems", TETRAHEDRON, vol. 52, no. 26, June 1996 (1996-06-01), pages 8707 - 8724, XP004103814 *

Also Published As

Publication number Publication date
EP2069345A2 (fr) 2009-06-17
WO2008012440A2 (fr) 2008-01-31
CA2658624A1 (fr) 2008-01-31
US9034873B2 (en) 2015-05-19
FR2904315A1 (fr) 2008-02-01
FR2904315B1 (fr) 2012-12-14
US20100298562A1 (en) 2010-11-25
JP5564252B2 (ja) 2014-07-30
JP2009544671A (ja) 2009-12-17

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