WO2008020260A3 - Utilisation de sidérophores dans la prévention des maladies vasculaires essentiellement causées par un dysfonctionnement des cellules de l'endothélium, production de sidérophores et évaluation des produits carnés contenant des sidérophores - Google Patents

Utilisation de sidérophores dans la prévention des maladies vasculaires essentiellement causées par un dysfonctionnement des cellules de l'endothélium, production de sidérophores et évaluation des produits carnés contenant des sidérophores Download PDF

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Publication number
WO2008020260A3
WO2008020260A3 PCT/HU2007/000076 HU2007000076W WO2008020260A3 WO 2008020260 A3 WO2008020260 A3 WO 2008020260A3 HU 2007000076 W HU2007000076 W HU 2007000076W WO 2008020260 A3 WO2008020260 A3 WO 2008020260A3
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WO
WIPO (PCT)
Prior art keywords
siderophores
production
vascular diseases
qualifying
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2007/000076
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English (en)
Other versions
WO2008020260A2 (fr
Inventor
Jozsef Balla
Gyoergy Balla
Istvan Pocsi
Laszlo Fesues
Viktoria Jeney
Imre Pocsi
Tamas Emri
Gyoengyi Gyemant
Gyula Roman
Istvan Kovacs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R-KO-N KFT
R KO N KFT
Original Assignee
R-KO-N KFT
R KO N KFT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0600653A external-priority patent/HU0600653D0/hu
Priority claimed from HU0700535A external-priority patent/HUP0700535A2/hu
Application filed by R-KO-N KFT, R KO N KFT filed Critical R-KO-N KFT
Publication of WO2008020260A2 publication Critical patent/WO2008020260A2/fr
Publication of WO2008020260A3 publication Critical patent/WO2008020260A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention se rapporte à l'utilisation de sidérophores fongiques dans le traitement des maladies vasculaires essentiellement causées par les cellules de l'endothélium, les composants selon ladite invention convenant particulièrement à une administration par voie orale. L'invention concerne également une voie de production privilégiée de sidérophores fongiques par l'utilisation d'espèces fongiques spécifiquement isolées et sélectionnées, ainsi que des aliments, et de préférence des produits carnés, en particulier la saucisse et le salami, qui contiennent des sidérophores en quantité efficace et contrôlée. L'invention se rapporte de plus à un système d'évaluation permettant de déterminer si différents aliments ont un effet préventif sur le système vasculaire, comme décrit ci-dessus.
PCT/HU2007/000076 2006-08-16 2007-08-16 Utilisation de sidérophores dans la prévention des maladies vasculaires essentiellement causées par un dysfonctionnement des cellules de l'endothélium, production de sidérophores et évaluation des produits carnés contenant des sidérophores Ceased WO2008020260A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HUP0600653 2006-08-16
HU0600653A HU0600653D0 (en) 2006-08-16 2006-08-16 Process for producing siderofor and siderofor-laden meat-product and use thereof
HUP0700535 2007-08-14
HU0700535A HUP0700535A2 (en) 2007-08-14 2007-08-14 Siderofor use for treatment vascular system, process for producing siderofor, and meat product that contain siderofor and qualification thereof

Publications (2)

Publication Number Publication Date
WO2008020260A2 WO2008020260A2 (fr) 2008-02-21
WO2008020260A3 true WO2008020260A3 (fr) 2008-10-02

Family

ID=89987695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2007/000076 Ceased WO2008020260A2 (fr) 2006-08-16 2007-08-16 Utilisation de sidérophores dans la prévention des maladies vasculaires essentiellement causées par un dysfonctionnement des cellules de l'endothélium, production de sidérophores et évaluation des produits carnés contenant des sidérophores

Country Status (1)

Country Link
WO (1) WO2008020260A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010009953A (es) 2008-03-14 2010-09-30 Astellas Pharma Inc Compuesto ciclico y sal del mismo.
CA2718394C (fr) 2008-03-14 2016-08-02 Astellas Pharma Inc. Microorganisme produisant un compose cyclique
GB201115417D0 (en) * 2011-09-06 2011-10-19 Ip Science Ltd Products and methods
CN105018352A (zh) * 2015-07-23 2015-11-04 云南大学 一种产曲酸真菌菌株及制备方法
CN114958946B (zh) * 2022-03-09 2024-03-26 山西勰成生物科技有限公司 一种发酵型红枣螯合肽铁的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297526A (en) * 1962-04-05 1967-01-10 Ciba Geigy Corp Process for producing coprogen and desferricoprogen
US3326885A (en) * 1962-02-16 1967-06-20 Ciba Geigy Corp Cyclic hexapeptides related to ferrichrome and ferrichrome a
US3342795A (en) * 1962-03-02 1967-09-19 Ciba Geigy Corp Ferrichrysin, desferrichrysin, and derivatives thereof
US5573800A (en) * 1989-02-21 1996-11-12 Viskase Corporation Antimicrobial composition for surface treatment of foodstuffs
US20040170728A1 (en) * 2003-02-28 2004-09-02 Kraft Foods Holdings, Inc. Use of siderophores and organic acids to retard lipid oxidation
WO2005067970A1 (fr) * 2004-01-14 2005-07-28 Gekkeikan Sake Co., Ltd. Complement de fer et son utilisation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3326885A (en) * 1962-02-16 1967-06-20 Ciba Geigy Corp Cyclic hexapeptides related to ferrichrome and ferrichrome a
US3342795A (en) * 1962-03-02 1967-09-19 Ciba Geigy Corp Ferrichrysin, desferrichrysin, and derivatives thereof
US3297526A (en) * 1962-04-05 1967-01-10 Ciba Geigy Corp Process for producing coprogen and desferricoprogen
US5573800A (en) * 1989-02-21 1996-11-12 Viskase Corporation Antimicrobial composition for surface treatment of foodstuffs
US20040170728A1 (en) * 2003-02-28 2004-09-02 Kraft Foods Holdings, Inc. Use of siderophores and organic acids to retard lipid oxidation
WO2005067970A1 (fr) * 2004-01-14 2005-07-28 Gekkeikan Sake Co., Ltd. Complement de fer et son utilisation
EP1704871A1 (fr) * 2004-01-14 2006-09-27 Gekkeikan Sake Co., Ltd. Complement de fer et son utilisation

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BURT W R: "IDENTIFICATION OF COPROGEN B AND ITS BREAKDOWN PRODUCTS FROM HISTOPLASMA-CAPSULATUM", INFECTION AND IMMUNITY, vol. 35, no. 3, 1982, pages 990 - 996, XP002465556, ISSN: 0019-9567 *
DUFFY STEPHEN J ET AL: "Iron chelation improves endothelial function in patients with coronary artery disease", CIRCULATION, vol. 103, no. 23, 12 June 2001 (2001-06-12), pages 2799 - 2804, XP002465555, ISSN: 0009-7322 *
FREDERICK C B ET AL: "PRODUCTION AND ISOLATION OF SIDEROPHORES FROM THE SOIL FUNGUS EPICOCCUM-PURPURASCENS", BIOCHEMISTRY, vol. 20, no. 9, 1981, pages 2432 - 2436, XP002465557, ISSN: 0006-2960 *
FREDERICK ET AL: "The structure of the fungal siderophore, isotriornicin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 105, no. 1, 1982, pages 133 - 138, XP009094278, ISSN: 0006-291X *
JALAL M A ET AL: "N alpha-dimethylcoprogens. Three novel trihydroxamate siderophores from pathogenic fungi.", BIOLOGY OF METALS 1988, vol. 1, no. 1, 1988, pages 4 - 8, XP002465558, ISSN: 0933-5854 *
KONETSCHNY-RAPP S ET AL: "HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY OF SIDEROPHORES FROM FUNGI", BIOLOGY OF METALS, SPRINGER VERLAG, BERLIN, DE, vol. 1, no. 1, 1 January 1988 (1988-01-01), pages 9 - 17, XP000984424, ISSN: 0933-5854 *
LAICH ET AL: "Isolation of Penicillium nalgiovense strains impaired in penicillin production by disruption of the pcbAB gene and application as starters on cured meat products", MYCOLOGICAL RESEARCH, ELSEVIER, GB, vol. 107, no. 6, 1 June 2003 (2003-06-01), pages 717 - 726, XP022443248, ISSN: 0953-7562 *
MINQIN R ET AL: "The iron chelator desferrioxamine inhibits atherosclerotic lesion development and decreases lesion iron concentrations in the cholesterol-fed rabbit", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, XX, vol. 38, no. 9, 1 May 2005 (2005-05-01), pages 1206 - 1211, XP004829702, ISSN: 0891-5849 *
ONG S A ET AL: "SIDEROPHORES IN MICROBIALLY PROCESSED CHEESE", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 27, no. 5, 1979, pages 990 - 995, XP002489693, ISSN: 0021-8561 *
PITT C G ET AL: "THE SELECTION AND EVALUATION OF NEW CHELATING AGENTS FOR THE TREATMENT OF IRON OVERLOAD", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 208, no. 1, 1979, pages 12 - 18, XP002915334, ISSN: 0022-3565 *
RENSHAW JOANNA C ET AL: "Fungal siderophores: Structures, functions and applications", MYCOLOGICAL RESEARCH, ELSEVIER,, GB, vol. 106, no. 10, October 2002 (2002-10-01), pages 1123 - 1142, XP009094238, ISSN: 0953-7562 *

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