WO2008022295A3 - Prlr-specific antibody and uses thereof - Google Patents

Prlr-specific antibody and uses thereof Download PDF

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Publication number
WO2008022295A3
WO2008022295A3 PCT/US2007/076160 US2007076160W WO2008022295A3 WO 2008022295 A3 WO2008022295 A3 WO 2008022295A3 US 2007076160 W US2007076160 W US 2007076160W WO 2008022295 A3 WO2008022295 A3 WO 2008022295A3
Authority
WO
WIPO (PCT)
Prior art keywords
prlr
specific antibody
antibody
preventing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/076160
Other languages
French (fr)
Other versions
WO2008022295A2 (en
Inventor
Daniel Bedinger
Jason Damiano
Mohammad Luqman
Linda Masat
Amer Mirza
Genevieve Nonet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Xoma Technology Ltd USA
Original Assignee
Novartis AG
Xoma Technology Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MEP-28/09A priority Critical patent/ME00588A/en
Priority to KR1020137005384A priority patent/KR101433544B1/en
Priority to EP07814191.8A priority patent/EP2059535B1/en
Priority to KR1020097003942A priority patent/KR101368596B1/en
Priority to BRPI0715718-5A2A priority patent/BRPI0715718A2/en
Priority to UAA200902394A priority patent/UA97484C2/en
Priority to RS20130576A priority patent/RS53092B/en
Priority to EP18166185.1A priority patent/EP3415532A1/en
Application filed by Novartis AG, Xoma Technology Ltd USA filed Critical Novartis AG
Priority to NZ574138A priority patent/NZ574138A/en
Priority to CA2661023A priority patent/CA2661023C/en
Priority to SI200731400T priority patent/SI2059535T1/en
Priority to KR1020147004402A priority patent/KR20140033241A/en
Priority to CN2007800302847A priority patent/CN101611058B/en
Priority to PL07814191T priority patent/PL2059535T3/en
Priority to DK07814191.8T priority patent/DK2059535T3/en
Priority to EA200970210A priority patent/EA017851B1/en
Priority to JP2009524812A priority patent/JP5517619B2/en
Priority to HK10104152.4A priority patent/HK1138603B/en
Priority to NZ596834A priority patent/NZ596834A/en
Priority to ES07814191.8T priority patent/ES2444065T3/en
Priority to MX2009001829A priority patent/MX2009001829A/en
Priority to AU2007285855A priority patent/AU2007285855B2/en
Priority to HRP20140081TT priority patent/HRP20140081T1/en
Publication of WO2008022295A2 publication Critical patent/WO2008022295A2/en
Publication of WO2008022295A3 publication Critical patent/WO2008022295A3/en
Priority to TNP2008000548A priority patent/TNSN08548A1/en
Priority to IL196397A priority patent/IL196397A/en
Priority to ZA2009/00351A priority patent/ZA200900351B/en
Anticipated expiration legal-status Critical
Priority to IL224266A priority patent/IL224266A/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones

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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.
PCT/US2007/076160 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof Ceased WO2008022295A2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
PL07814191T PL2059535T3 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
EP07814191.8A EP2059535B1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
KR1020097003942A KR101368596B1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
BRPI0715718-5A2A BRPI0715718A2 (en) 2006-08-18 2007-08-17 ANTIBODY, METHODS OF TRIARING TO AN ANTIBODY FOR THE EXTRACELLULAR DOMAIN OF A PRLR PROTEIN, SYSTEMATICALLY CHANGING ANTIBODIES AND TRIATING TO AN ANTIBODY FOR AN EXTRACELLULAR DOMAIN, OF A CURREN ALTERNATE EXPRESSA PRLR, TO USE A HOSPITAL CELL, TO IDENTIFY AN INDIVIDUAL OF TREATMENT WITH AN ANTI-PRLR ANTIBODY, AND TO MONITOR CANCER THERAPY IN AN INDIVIDUAL, ISOLATED NUCLEIC ACID COMPLETE MOLECULES And, KIT
UAA200902394A UA97484C2 (en) 2006-08-18 2007-08-17 Isolated antibody that binds the extracellular domain of prlr
RS20130576A RS53092B (en) 2006-08-18 2007-08-17 PRLR-SPECIFIC ANTIBODY AND ITS USES
EP18166185.1A EP3415532A1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
EA200970210A EA017851B1 (en) 2006-08-18 2007-08-17 PRLR-SPECIFIC ANTIBODY AND ITS APPLICATIONS
NZ574138A NZ574138A (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
CA2661023A CA2661023C (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
SI200731400T SI2059535T1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
KR1020147004402A KR20140033241A (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
CN2007800302847A CN101611058B (en) 2006-08-18 2007-08-17 PRLR-specific antibodies and uses thereof
DK07814191.8T DK2059535T3 (en) 2006-08-18 2007-08-17 PRLR-SPECIFIC ANTIBODY AND APPLICATIONS THEREOF
JP2009524812A JP5517619B2 (en) 2006-08-18 2007-08-17 PRLR-specific antibodies and uses thereof
MEP-28/09A ME00588A (en) 2006-08-18 2007-08-17 ANTIBODY SPECIFIC TO PRLR AND ITS USE
KR1020137005384A KR101433544B1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
HK10104152.4A HK1138603B (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
NZ596834A NZ596834A (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
ES07814191.8T ES2444065T3 (en) 2006-08-18 2007-08-17 Specific antibody for PRLR and uses thereof
MX2009001829A MX2009001829A (en) 2006-08-18 2007-08-17 PRLR SPECIFIC ANTIBODY AND ITS USES.
AU2007285855A AU2007285855B2 (en) 2006-08-18 2007-08-17 PRLR-specific antibody and uses thereof
HRP20140081TT HRP20140081T1 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof
TNP2008000548A TNSN08548A1 (en) 2006-08-18 2008-12-31 Prlr-specific antibody and uses thereof
IL196397A IL196397A (en) 2006-08-18 2009-01-08 Prlr-specific antibody and uses thereof
ZA2009/00351A ZA200900351B (en) 2006-08-18 2009-01-15 Prlr-specific antibody and uses thereof
IL224266A IL224266A (en) 2006-08-18 2013-01-17 Prlr-specific antibody and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83864806P 2006-08-18 2006-08-18
US60/838,648 2006-08-18
US94636007P 2007-06-26 2007-06-26
US60/946,360 2007-06-26

Publications (2)

Publication Number Publication Date
WO2008022295A2 WO2008022295A2 (en) 2008-02-21
WO2008022295A3 true WO2008022295A3 (en) 2008-10-09

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ID=39083161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/076160 Ceased WO2008022295A2 (en) 2006-08-18 2007-08-17 Prlr-specific antibody and uses thereof

Country Status (37)

Country Link
US (3) US7867493B2 (en)
EP (4) EP3018144A1 (en)
JP (3) JP5517619B2 (en)
KR (3) KR20140033241A (en)
CN (2) CN101611058B (en)
AR (2) AR062435A1 (en)
AU (1) AU2007285855B2 (en)
BR (1) BRPI0715718A2 (en)
CA (2) CA2932012A1 (en)
CL (1) CL2007002412A1 (en)
CO (1) CO6150194A2 (en)
CR (1) CR10612A (en)
CU (1) CU23809A3 (en)
CY (1) CY1114904T1 (en)
DK (1) DK2059535T3 (en)
EA (2) EA017851B1 (en)
ES (1) ES2444065T3 (en)
GE (1) GEP20125612B (en)
GT (1) GT200900035A (en)
HN (1) HN2009000379A (en)
HR (1) HRP20140081T1 (en)
IL (2) IL196397A (en)
MA (1) MA30762B1 (en)
ME (1) ME00588A (en)
MX (1) MX2009001829A (en)
MY (1) MY145058A (en)
NI (1) NI200900022A (en)
NZ (2) NZ574138A (en)
PE (1) PE20081214A1 (en)
PL (1) PL2059535T3 (en)
PT (1) PT2059535E (en)
RS (1) RS53092B (en)
SI (1) SI2059535T1 (en)
TN (1) TNSN08548A1 (en)
TW (2) TW201441262A (en)
WO (1) WO2008022295A2 (en)
ZA (1) ZA200900351B (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3018144A1 (en) * 2006-08-18 2016-05-11 XOMA Technology Ltd. Prlr-specific antibody and uses thereof
EP2277044B1 (en) * 2008-05-13 2015-06-17 Genentech, Inc. Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry
PT3023438T (en) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anti-gitr antibodies
WO2011038301A2 (en) 2009-09-25 2011-03-31 Xoma Technology Ltd. Screening methods
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