WO2008027385A3 - Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole - Google Patents

Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole Download PDF

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Publication number
WO2008027385A3
WO2008027385A3 PCT/US2007/018923 US2007018923W WO2008027385A3 WO 2008027385 A3 WO2008027385 A3 WO 2008027385A3 US 2007018923 W US2007018923 W US 2007018923W WO 2008027385 A3 WO2008027385 A3 WO 2008027385A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrazole
phenyl
synthesis
trityl
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/018923
Other languages
French (fr)
Other versions
WO2008027385A2 (en
Inventor
Vinod Kumar Kansal
Dhirenkumar N Mistry
Sanjay L Vasoya
Vijaykumar D Lunagariya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Industries Ltd
Priority to JP2008538214A priority Critical patent/JP2009515834A/en
Priority to EP07837444A priority patent/EP1931648A2/en
Publication of WO2008027385A2 publication Critical patent/WO2008027385A2/en
Publication of WO2008027385A3 publication Critical patent/WO2008027385A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Provided are processes for the synthesis of 5 -phenyl- 1-trityl-lH-tetrazole, an intermediate useful in the synthesis of irbesartan. The tritylation of 5-phenyl-lH-tetrazole is carried out using phase transfer catalysis in a biphasic solvent system.
PCT/US2007/018923 2006-08-29 2007-08-28 Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole Ceased WO2008027385A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008538214A JP2009515834A (en) 2006-08-29 2007-08-28 Method for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
EP07837444A EP1931648A2 (en) 2006-08-29 2007-08-28 Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84116306P 2006-08-29 2006-08-29
US60/841,163 2006-08-29
US90207907P 2007-02-20 2007-02-20
US60/902,079 2007-02-20

Publications (2)

Publication Number Publication Date
WO2008027385A2 WO2008027385A2 (en) 2008-03-06
WO2008027385A3 true WO2008027385A3 (en) 2008-04-17

Family

ID=38988296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018923 Ceased WO2008027385A2 (en) 2006-08-29 2007-08-28 Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole

Country Status (5)

Country Link
US (1) US20080103312A1 (en)
EP (1) EP1931648A2 (en)
JP (1) JP2009515834A (en)
ES (1) ES2302671T1 (en)
WO (1) WO2008027385A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240051999A (en) * 2021-08-26 2024-04-22 상하이 한서 바이오메디컬 컴퍼니 리미티드 Aromatic ring-containing biological antagonists, preparation method and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
WO1994011012A1 (en) * 1992-11-06 1994-05-26 Merck & Co., Inc. Substituted dipeptide analogs promote release of growth hormone
WO2004007482A2 (en) * 2002-07-16 2004-01-22 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE69507887T2 (en) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka METHOD FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVES OR THEIR SALTS, AND INTERMEDIATE COMPOUNDS REQUIRED FOR THEM

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
WO1994011012A1 (en) * 1992-11-06 1994-05-26 Merck & Co., Inc. Substituted dipeptide analogs promote release of growth hormone
WO2004007482A2 (en) * 2002-07-16 2004-01-22 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MYZNIKOV L V ET AL: "Tetrazoles : XLIV. Synthesis and chemical properties of 5-substituted 2-triphenylmethyltetrazoles", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 38, no. 9, 2002, pages 1360 - 1369, XP009095769, ISSN: 1070-4280 *

Also Published As

Publication number Publication date
ES2302671T1 (en) 2008-08-01
JP2009515834A (en) 2009-04-16
WO2008027385A2 (en) 2008-03-06
US20080103312A1 (en) 2008-05-01
EP1931648A2 (en) 2008-06-18

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