WO2008041190A3 - Methods and systems for detection with front irradiation - Google Patents

Methods and systems for detection with front irradiation Download PDF

Info

Publication number
WO2008041190A3
WO2008041190A3 PCT/IB2007/054022 IB2007054022W WO2008041190A3 WO 2008041190 A3 WO2008041190 A3 WO 2008041190A3 IB 2007054022 W IB2007054022 W IB 2007054022W WO 2008041190 A3 WO2008041190 A3 WO 2008041190A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
detection
sample
detection system
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/054022
Other languages
French (fr)
Other versions
WO2008041190A2 (en
Inventor
Mark T Johnson
Marc W G Ponjee
Marcello L M Balistreri
Herpen Maarten M J W Van
Derk J W Klunder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Priority to EP07826639A priority Critical patent/EP2074409A2/en
Priority to US12/443,863 priority patent/US20100096561A1/en
Priority to JP2009530995A priority patent/JP2010506164A/en
Priority to BRPI0718201-5A priority patent/BRPI0718201A2/en
Publication of WO2008041190A2 publication Critical patent/WO2008041190A2/en
Publication of WO2008041190A3 publication Critical patent/WO2008041190A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).
PCT/IB2007/054022 2006-10-05 2007-10-03 Methods and systems for detection with front irradiation Ceased WO2008041190A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07826639A EP2074409A2 (en) 2006-10-05 2007-10-03 Methods and systems for detection with front irradiation
US12/443,863 US20100096561A1 (en) 2006-10-05 2007-10-03 Methods and systems for detection with front irradiation
JP2009530995A JP2010506164A (en) 2006-10-05 2007-10-03 Method and system for detection by forward illumination
BRPI0718201-5A BRPI0718201A2 (en) 2006-10-05 2007-10-03 SYSTEM AND METHOD FOR DETECTING RADIATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06121789 2006-10-05
EP06121789.9 2006-10-05

Publications (2)

Publication Number Publication Date
WO2008041190A2 WO2008041190A2 (en) 2008-04-10
WO2008041190A3 true WO2008041190A3 (en) 2008-07-03

Family

ID=39166307

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/054022 Ceased WO2008041190A2 (en) 2006-10-05 2007-10-03 Methods and systems for detection with front irradiation

Country Status (8)

Country Link
US (1) US20100096561A1 (en)
EP (1) EP2074409A2 (en)
JP (1) JP2010506164A (en)
KR (1) KR20090060423A (en)
CN (1) CN101523198A (en)
BR (1) BRPI0718201A2 (en)
RU (1) RU2009116936A (en)
WO (1) WO2008041190A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8696991B1 (en) 2010-01-04 2014-04-15 Harold W. Howe Field deployable surface plasmon resonance based biosensor
BR112015013166A2 (en) 2012-12-05 2017-07-11 Genepoc Inc optical interrogation device
EP3055672A1 (en) * 2013-12-19 2016-08-17 Halliburton Energy Services, Inc. Using tunable lasers in the design, manufacture, and implementation of integrated optical elements
WO2016023010A1 (en) * 2014-08-08 2016-02-11 Quantum-Si Incorporated Optical system and assay chip for probing, detecting, and analyzing molecules
US10119915B2 (en) 2015-04-09 2018-11-06 Visera Technologies Company Limited Detection device for specimens
US10488639B2 (en) * 2015-10-08 2019-11-26 Visera Technologies Company Limited Detection device for specimens
WO2017096504A1 (en) * 2015-12-07 2017-06-15 Shenzhen Genorivision Technology Co. Ltd. A biosensor
EP4320426A4 (en) * 2021-04-07 2025-03-12 Illumina, Inc. ADJUSTABLE ILLUMINATION PATTERN FOR SAMPLE ANALYSIS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872623A (en) * 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
GB2351556A (en) * 1999-06-26 2001-01-03 Cambridge Imaging Ltd Improved assay analysis
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5699157A (en) * 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US6627895B2 (en) * 1998-08-28 2003-09-30 Fuji Photo Film Co., Ltd. Radiation image detecting system
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
JP3741051B2 (en) * 2001-05-10 2006-02-01 横河電機株式会社 Biochip reader
US20050130226A1 (en) * 2003-09-26 2005-06-16 The University Of Cincinnati Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
US7295316B2 (en) * 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872623A (en) * 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
GB2351556A (en) * 1999-06-26 2001-01-03 Cambridge Imaging Ltd Improved assay analysis
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIAOQIU HUANG ET AL: "Development of active matrix biosensor array for cell screening", SENSORS, 2004. PROCEEDINGS OF IEEE VIENNA, AUSTRIA OCT. 24 - 27, 2004, PISCATAWAY, NJ, USA,IEEE, 24 October 2004 (2004-10-24), pages 72 - 75, XP010793336, ISBN: 0-7803-8692-2 *

Also Published As

Publication number Publication date
BRPI0718201A2 (en) 2013-11-05
US20100096561A1 (en) 2010-04-22
JP2010506164A (en) 2010-02-25
CN101523198A (en) 2009-09-02
RU2009116936A (en) 2010-11-10
EP2074409A2 (en) 2009-07-01
WO2008041190A2 (en) 2008-04-10
KR20090060423A (en) 2009-06-12

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