WO2008047086A3 - Biomarker - Google Patents

Biomarker Download PDF

Info

Publication number
WO2008047086A3
WO2008047086A3 PCT/GB2007/003913 GB2007003913W WO2008047086A3 WO 2008047086 A3 WO2008047086 A3 WO 2008047086A3 GB 2007003913 W GB2007003913 W GB 2007003913W WO 2008047086 A3 WO2008047086 A3 WO 2008047086A3
Authority
WO
WIPO (PCT)
Prior art keywords
complement
sample
subject
determining
precursor protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/003913
Other languages
French (fr)
Other versions
WO2008047086A2 (en
Inventor
William Atiomo
Robert Layfield
Catherine Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nottingham
Original Assignee
University of Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0620467A external-priority patent/GB0620467D0/en
Priority claimed from GB0708064A external-priority patent/GB0708064D0/en
Application filed by University of Nottingham filed Critical University of Nottingham
Priority to JP2009532885A priority Critical patent/JP2010507093A/en
Priority to EP07824164A priority patent/EP2076771A2/en
Publication of WO2008047086A2 publication Critical patent/WO2008047086A2/en
Publication of WO2008047086A3 publication Critical patent/WO2008047086A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/361—Menstrual abnormalities or abnormal uterine bleeding, e.g. dysmenorrhea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method of determining the Polycystic Ovarian Syndrome (PCOS) status of a subject, comprising the steps of (i) providing a sample of material obtained from a subject; (ii) determining the level of one or more of the following proteins: the complement C4 precursor protein; a cleavage fragment of the complement C4 precursor protein; and a haptoglobin; in the sample and (iii) comparing the levels determined with one or more reference values.
PCT/GB2007/003913 2006-10-16 2007-10-15 Biomarker Ceased WO2008047086A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009532885A JP2010507093A (en) 2006-10-16 2007-10-15 Biomarker
EP07824164A EP2076771A2 (en) 2006-10-16 2007-10-15 Biomarker

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0620467.1 2006-10-16
GB0620467A GB0620467D0 (en) 2006-10-16 2006-10-16 Biomarker
GB0708064.1 2007-04-26
GB0708064A GB0708064D0 (en) 2007-04-26 2007-04-26 Biomarker

Publications (2)

Publication Number Publication Date
WO2008047086A2 WO2008047086A2 (en) 2008-04-24
WO2008047086A3 true WO2008047086A3 (en) 2008-07-17

Family

ID=38834488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/003913 Ceased WO2008047086A2 (en) 2006-10-16 2007-10-15 Biomarker

Country Status (3)

Country Link
EP (1) EP2076771A2 (en)
JP (1) JP2010507093A (en)
WO (1) WO2008047086A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2153234A2 (en) 2007-05-11 2010-02-17 The Institutes for Pharmaceutical Discovery, LLC Methods for early diagnosis of kidney disease
WO2013079560A1 (en) 2011-11-29 2013-06-06 Westfälische Wilhelms-Universität Münster Genetic marker for polycystic ovary syndrome (pcos)
JP5924587B2 (en) * 2012-09-18 2016-05-25 国立大学法人 鹿児島大学 Blood HCV detection method and effect determination method of anti-HCV treatment
CN106442764B (en) * 2016-08-31 2019-01-22 王义明 The diagnosis of Stein-Leventhal syndrome and/or the purposes of parting marker and reagent preparation
CN111148844A (en) 2017-09-01 2020-05-12 韦恩生物科技股份公司 Identification and use of glycopeptides as biomarkers for diagnosis and therapeutic monitoring

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEIJING DA XUE XUE BAO. YI XUE BAN = JOURNAL OF PEKING UNIVERSITY. HEALTH SCIENCES 18 AUG 2005, vol. 37, no. 4, 18 August 2005 (2005-08-18), pages 362 - 365, ISSN: 1671-167X *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 18 August 2005 (2005-08-18), ZHAO SHU-YUN ET AL: "[Protein expression profilings of polycystic ovary syndrome]", XP002463463, Database accession no. NLM16086052 *
HUGHES CATHERINE ET AL: "Genomic and post-genomic approaches to polycystic ovary syndrome - progress so far: Mini Review", 26 August 2006, HUMAN REPRODUCTION (OXFORD), VOL. 21, NR. 11, PAGE(S) 2766-2775, ISSN: 0268-1161, XP002463462 *
MATHAROO-BALL B ET AL: "Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms", August 2007, JOURNAL OF PROTEOME RESEARCH, VOL. 6, NR. 8, PAGE(S) 3321-3328, ISSN: 1535-3893, XP002463465 *
WOOD JENNIFER R ET AL: "The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis.", 18 July 2003, THE JOURNAL OF BIOLOGICAL CHEMISTRY 18 JUL 2003, VOL. 278, NR. 29, PAGE(S) 26380 - 26390, ISSN: 0021-9258, XP002463464 *

Also Published As

Publication number Publication date
JP2010507093A (en) 2010-03-04
WO2008047086A2 (en) 2008-04-24
EP2076771A2 (en) 2009-07-08

Similar Documents

Publication Publication Date Title
WO2008045307A3 (en) Emissive compositions with internal standard and related techniques
WO2007098279A3 (en) Analyte detection using barcoded polymers
WO2008048970A3 (en) Synthetic antibodies
WO2008015254A3 (en) Means and methods for assessing the risk of cardiac interventions based on gdf-15
EP2402437A3 (en) Protease screening methods and proteases identified thereby
WO2005077007A3 (en) Methods of diagnosing and treating pre-eclampsia or eclampsia
WO2008064658A3 (en) Method for testing a computer programme
WO2005003394A3 (en) Bio-barcode based detection of target analytes
WO2008047086A3 (en) Biomarker
WO2008060483A3 (en) Protein-protein interaction biosensors and methods of use thereof
WO2008102340A3 (en) Kits and methods for determining colon cleanliness
WO2010079076A3 (en) Autosomal dominant polycystic kidney disease (adpkd)
WO2010009074A3 (en) Method for predicting and detecting tumor metastasis
UA101142C2 (en) Method for antibody designing
WO2008065682A3 (en) Genetic susceptibility variants of type 2 diabetes mellitus
WO2006076687A3 (en) Elisa assays using prion-specific peptide reagents
WO2007001895A3 (en) Monoclonal antibodies, hybridoma cell lines, methods and kits for detecting phytase
WO2007117794A3 (en) Glycated peptides and methods of use
WO2007067433A3 (en) Poly(trimethylene terephthalate)/poly(alpha-hydroxy acid) films
ATE529749T1 (en) CHROMATOGRAPHIC TEST STRIPS FOR ONE OR MORE ANALYTES
WO2006110748A3 (en) Response gene to complement 32 (rgc-32) in disease
WO2009007858A3 (en) Method for detecting and quantifying analytes on a solid support with liposome-encapsulated fluorescent molecules
WO2005007866A3 (en) Biochip devices for ion transport measurement, methods of manufacture, and methods of use
WO2008041849A3 (en) Methods and means for determining satiety on saliva
WO2022260599A3 (en) Method of predicting the likelihood of hyperglycemia

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07824164

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2009532885

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007824164

Country of ref document: EP