WO2008048683A3 - Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates - Google Patents

Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates Download PDF

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Publication number
WO2008048683A3
WO2008048683A3 PCT/US2007/022321 US2007022321W WO2008048683A3 WO 2008048683 A3 WO2008048683 A3 WO 2008048683A3 US 2007022321 W US2007022321 W US 2007022321W WO 2008048683 A3 WO2008048683 A3 WO 2008048683A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazo
quinolin
preparation
amines via
phthalimide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/022321
Other languages
French (fr)
Other versions
WO2008048683A2 (en
Inventor
Janos Hajko
Csaba Szabo
Piroska Kovacs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Works PLC
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Works PLC, Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Works PLC
Priority to BRPI0706205-2A priority Critical patent/BRPI0706205A2/en
Priority to EP07852861A priority patent/EP1966205A2/en
Publication of WO2008048683A2 publication Critical patent/WO2008048683A2/en
Publication of WO2008048683A3 publication Critical patent/WO2008048683A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides process for the preparation of 4-amino-1H-imidazo[4,5-c]quinolines comprising the step of reacting a 1H-imidazo[4,5-c]quinolin-4-phthalimide with an amine selected from the group consisting of: alkylamine, aralkylamine, alkyldiamine, and aralkyldiamine.
PCT/US2007/022321 2006-10-16 2007-10-16 Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates Ceased WO2008048683A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0706205-2A BRPI0706205A2 (en) 2006-10-16 2007-10-16 1h imidazo [4,5-c] quinolin-4-amines preparation via intermediates 1h-imidazo [4,5-c] quinolin-4-phthalimide intermediates
EP07852861A EP1966205A2 (en) 2006-10-16 2007-10-16 Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US85215306P 2006-10-16 2006-10-16
US60/852,153 2006-10-16
US89997407P 2007-02-06 2007-02-06
US60/899,974 2007-02-06
US92034907P 2007-03-26 2007-03-26
US60/920,349 2007-03-26

Publications (2)

Publication Number Publication Date
WO2008048683A2 WO2008048683A2 (en) 2008-04-24
WO2008048683A3 true WO2008048683A3 (en) 2008-06-05

Family

ID=39156147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/022321 Ceased WO2008048683A2 (en) 2006-10-16 2007-10-16 Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates

Country Status (3)

Country Link
EP (1) EP1966205A2 (en)
BR (1) BRPI0706205A2 (en)
WO (1) WO2008048683A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009593A1 (en) * 2002-07-23 2004-01-29 Biogal Gyogyszergyar Rt. Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via1h-imidazo [4,5-c]quinolin-4-phthalimide intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009593A1 (en) * 2002-07-23 2004-01-29 Biogal Gyogyszergyar Rt. Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via1h-imidazo [4,5-c]quinolin-4-phthalimide intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GREENE T W ET AL: "Protective Groups in Organic Synthesis, 3rd Edition", 1999, WILEY & SONS, NEW YORK, US, XP002472855 *

Also Published As

Publication number Publication date
BRPI0706205A2 (en) 2011-03-22
WO2008048683A2 (en) 2008-04-24
EP1966205A2 (en) 2008-09-10

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