WO2008078674A1 - グルコキナーゼ活性化物質 - Google Patents

グルコキナーゼ活性化物質 Download PDF

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Publication number
WO2008078674A1
WO2008078674A1 PCT/JP2007/074638 JP2007074638W WO2008078674A1 WO 2008078674 A1 WO2008078674 A1 WO 2008078674A1 JP 2007074638 W JP2007074638 W JP 2007074638W WO 2008078674 A1 WO2008078674 A1 WO 2008078674A1
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Prior art keywords
group
glucokinase
activating substance
atom
asterisk
Prior art date
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PCT/JP2007/074638
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English (en)
French (fr)
Inventor
Yasumichi Fukuda
Yoshikazu Asahina
Ayako Nakamura
Kenji Fujita
Tomohiro Ide
Fumiyoshi Kobayashi
Shinji Kobayashi
Kanji Komatsu
Masanori Yamamoto
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Kyorin Pharmaceutical Co Ltd
Teijin Pharma Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Teijin Pharma Ltd
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Application filed by Kyorin Pharmaceutical Co Ltd, Teijin Pharma Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to CN2007800517548A priority Critical patent/CN101668743B/zh
Priority to BRPI0719470-6A priority patent/BRPI0719470A2/pt
Priority to US12/448,549 priority patent/US8173649B2/en
Priority to MX2009006907A priority patent/MX2009006907A/es
Priority to JP2008551077A priority patent/JP5248327B2/ja
Priority to AU2007337382A priority patent/AU2007337382A1/en
Priority to EP07851044.3A priority patent/EP2116535B1/en
Priority to CA2672088A priority patent/CA2672088C/en
Publication of WO2008078674A1 publication Critical patent/WO2008078674A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

【解決手段】　 式（１） （式中、＊を付した炭素原子の立体配置がＲ配置であり、Ｒ１及びＲ２は、同一又は異なって水素原子、ハロゲン原子、アミノ基、水酸基、ヒドロキシアミノ基、ニトロ基、シアノ基、スルファモイル基、Ｃ１～Ｃ６のアルキル基、Ｃ１～Ｃ６のアルコキシ基、Ｃ１～Ｃ６のアルキルスルファニル基、Ｃ１～Ｃ６のアルキルスルフィニル基又はＣ１～Ｃ６のアルキルスルホニル基を示し、Ａは置換基を有してもよいヘテロアリール基を示す。）で表される化合物又は薬学的に許容されるその塩。
PCT/JP2007/074638 2006-12-25 2007-12-21 グルコキナーゼ活性化物質 Ceased WO2008078674A1 (ja)

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BRPI0719470-6A BRPI0719470A2 (pt) 2006-12-25 2007-12-21 "composto representado pela fórmula 1, método para tratamento ou prevenção de diabetes, uso do composto e composição farmacêutica contendo ativador de glucocinase" c07d 277/46 c07d 277/82 c07d 285/08 c07d 417/04 c07d 471/04 c07d 487/04 c07d 498/04 c07d 513/04
US12/448,549 US8173649B2 (en) 2006-12-25 2007-12-21 Glucokinase activator
MX2009006907A MX2009006907A (es) 2006-12-25 2007-12-21 Activador de glucocinasa.
JP2008551077A JP5248327B2 (ja) 2006-12-25 2007-12-21 グルコキナーゼ活性化物質
AU2007337382A AU2007337382A1 (en) 2006-12-25 2007-12-21 Glucokinase-activating substance
EP07851044.3A EP2116535B1 (en) 2006-12-25 2007-12-21 Glucokinase-activating substance
CA2672088A CA2672088C (en) 2006-12-25 2007-12-21 Glucokinase activator

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091014A1 (ja) 2008-01-18 2009-07-23 Astellas Pharma Inc. フェニルアセトアミド誘導体
WO2009133687A1 (ja) * 2008-04-28 2009-11-05 杏林製薬株式会社 シクロペンチルアクリル酸アミド誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011123572A1 (en) 2010-03-31 2011-10-06 The Scripps Research Institute Reprogramming cells
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2012512134A (ja) * 2008-08-19 2012-05-31 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷感−メントール受容体拮抗剤
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP5248477B2 (ja) * 2007-03-07 2013-07-31 杏林製薬株式会社 グルコキナーゼ活性化物質
EP2878339A1 (en) 2013-12-02 2015-06-03 Siena Biotech S.p.A. SIP3 antagonists
US9663529B2 (en) 2013-07-02 2017-05-30 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
US9914740B2 (en) 2013-07-02 2018-03-13 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07506816A (ja) 1992-03-09 1995-07-27 ザ　ウエルカム　ファウンデーション　リミテッド 抗ウイルス性ヌクレオシド類縁体
WO2000058293A2 (en) 1999-03-29 2000-10-05 F. Hoffmann-La Roche Ag Glucokinase activators
WO2001044216A1 (en) 1999-12-15 2001-06-21 F. Hoffmann-La Roche Ag Trans olefinic glucokinase activators
WO2001083465A2 (en) 2000-05-03 2001-11-08 F. Hoffmann-La Roche Ag Alkynyl phenyl heteroaromatic glucokinase activators
WO2001083478A2 (en) 2000-05-03 2001-11-08 F. Hoffmann-La Roche Ag Hydantoin-containing glucokinase activators
WO2001085707A1 (en) 2000-05-08 2001-11-15 F. Hoffmann-La Roche Ag Para-amine substituted phenylamide glucokinase activators
WO2001085706A1 (en) 2000-05-08 2001-11-15 F. Hoffmann-La Roche Ag Substituted phenylacetamides and their use as glucokinase activators
WO2002008209A1 (en) 2000-07-20 2002-01-31 F. Hoffmann-La Roche Ag Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators
WO2002014312A1 (en) 2000-08-15 2002-02-21 F. Hoffmann-La Roche Ag Tetrazolyl-phenyl acetamide glucokinase activators
WO2002046173A1 (en) 2000-12-06 2002-06-13 F. Hoffmann-La Roche Ag Fused heteroaromatic glucokinase activators
WO2003095438A1 (en) 2002-04-26 2003-11-20 F. Hoffmann-La Roche Ag Substituted phenylacetamides and their use as glucokinase activators
WO2004052869A1 (en) 2002-12-12 2004-06-24 F. Hoffmann-La Roche Ag 5-substituted-pyrazine or pyridine glucokinase activators
WO2004072031A2 (en) 2003-02-11 2004-08-26 Prosidion Limited Phenylacetamides and their use as glucokinase modulators
WO2004072066A1 (en) 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
US6911545B2 (en) 2001-12-19 2005-06-28 Hoffman-La Roche Inc. Crystals of glucokinase and methods of growing them
WO2005103021A1 (en) 2004-04-21 2005-11-03 Prosidion Limited Tri(cyclo) substituted amide compounds
WO2006016194A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Substituted phenylacetamides and their use as glucokinase activators
WO2006016178A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Enantioselective process
WO2006016174A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Fluorination process of protected aminothiazole
WO2006059163A1 (en) 2004-12-02 2006-06-08 Prosidion Limited Treatment of diabetes with glycogen phosphorylase inhibitors
WO2008012227A2 (en) * 2006-07-24 2008-01-31 F. Hoffmann-La Roche Ag Pyrazoles as glucokinase activators

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6064299A (en) * 1995-11-09 2000-05-16 Vehicle Enhancement Systems, Inc. Apparatus and method for data communication between heavy duty vehicle and remote data communication terminal
RU2242469C2 (ru) 1999-03-29 2004-12-20 Ф.Хоффманн-Ля Рош Аг Активаторы глюкокиназы
SE514080C2 (sv) * 1999-04-16 2000-12-18 Ericsson Telefon Ab L M Filter
US6489485B2 (en) 2000-05-08 2002-12-03 Hoffmann-La Roche Inc. Para-amine substituted phenylamide glucokinase activators
US6433188B1 (en) 2000-12-06 2002-08-13 Wendy Lea Corbett Fused heteroaromatic glucokinase activators
US6482951B2 (en) 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
US6587288B2 (en) * 2001-03-12 2003-07-01 Optical Coating Laboratory, Inc. Optical attenuation filter
AU2003234548A1 (en) 2002-05-14 2003-12-02 E.I. Du Pont De Nemours And Company Solubilized formulations containing nylon suitable for personal care products
MXPA05003559A (es) 2002-10-03 2005-06-03 Novartis Ag (tiazol-2-il)-amida o sulfonamida substituida como activadores de glicocinasa utiles en el tratamiento de diabetes de tipo 2.
WO2004063194A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
AU2005229416B2 (en) 2004-04-02 2009-03-26 Novartis Ag Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes
KR20070006816A (ko) 2004-04-02 2007-01-11 노파르티스 아게 티아졸로피리딘 유도체, 이를 함유하는 제약 조성물 및글루코키나제 매개형 증상의 치료 방법
US8148412B2 (en) 2004-12-03 2012-04-03 Novo Nordisk A/S Heteroaromatic glucokinase activators
EP1832129B1 (en) * 2004-12-31 2011-11-23 Telefonaktiebolaget LM Ericsson (publ) Telecommunication system and method for transferring sms messages between terminals and intelligent network services.
EP1921074A1 (en) 2005-08-31 2008-05-14 Astellas Pharma Inc. Thiazole derivative
GT200600428A (es) 2005-09-30 2007-05-21 Compuestos organicos
GT200600429A (es) 2005-09-30 2007-04-30 Compuestos organicos
CN101296917A (zh) 2005-10-24 2008-10-29 霍夫曼-拉罗奇有限公司 由法沃斯基重排制备环状缩酮化酮及该方法在制备葡糖激酶活化剂70中的应用
JP2009514835A (ja) 2005-11-03 2009-04-09 プロシディオン・リミテッド トリシクロ置換型アミド
US20080293741A1 (en) 2005-11-03 2008-11-27 Matthew Colin Thor Fyfe Tricyclo Substituted Amides as Glucokinase Modulators
EP1948645A1 (en) 2005-11-03 2008-07-30 Prosidion Limited Tricyclo substituted amides
US7888504B2 (en) 2006-07-06 2011-02-15 Bristol-Myers Squibb Company Glucokinase activators and methods of using same
US7910747B2 (en) 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
MX2009009525A (es) * 2007-03-07 2009-09-16 Kyorin Seiyaku Kk Activador de glucocinasa.
HRP20150842T1 (hr) 2008-04-28 2015-09-11 Kyorin Pharmaceutical Co., Ltd. Derivati ciklopentilakrilamida

Patent Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07506816A (ja) 1992-03-09 1995-07-27 ザ　ウエルカム　ファウンデーション　リミテッド 抗ウイルス性ヌクレオシド類縁体
WO2000058293A2 (en) 1999-03-29 2000-10-05 F. Hoffmann-La Roche Ag Glucokinase activators
WO2001044216A1 (en) 1999-12-15 2001-06-21 F. Hoffmann-La Roche Ag Trans olefinic glucokinase activators
WO2001083465A2 (en) 2000-05-03 2001-11-08 F. Hoffmann-La Roche Ag Alkynyl phenyl heteroaromatic glucokinase activators
WO2001083478A2 (en) 2000-05-03 2001-11-08 F. Hoffmann-La Roche Ag Hydantoin-containing glucokinase activators
WO2001085706A1 (en) 2000-05-08 2001-11-15 F. Hoffmann-La Roche Ag Substituted phenylacetamides and their use as glucokinase activators
WO2001085707A1 (en) 2000-05-08 2001-11-15 F. Hoffmann-La Roche Ag Para-amine substituted phenylamide glucokinase activators
WO2002008209A1 (en) 2000-07-20 2002-01-31 F. Hoffmann-La Roche Ag Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators
WO2002014312A1 (en) 2000-08-15 2002-02-21 F. Hoffmann-La Roche Ag Tetrazolyl-phenyl acetamide glucokinase activators
WO2002046173A1 (en) 2000-12-06 2002-06-13 F. Hoffmann-La Roche Ag Fused heteroaromatic glucokinase activators
JP2004517087A (ja) * 2000-12-06 2004-06-10 エフ．ホフマン−ラ　ロシュ　アーゲー 縮合複素環式芳香族グルコキナーゼアクチベーター
US6911545B2 (en) 2001-12-19 2005-06-28 Hoffman-La Roche Inc. Crystals of glucokinase and methods of growing them
WO2003095438A1 (en) 2002-04-26 2003-11-20 F. Hoffmann-La Roche Ag Substituted phenylacetamides and their use as glucokinase activators
JP2005535589A (ja) * 2002-04-26 2005-11-24 エフ．ホフマン−ラ　ロシュ　アーゲー 置換フェニルアセトアミド及びグルコキナーゼ活性化物質としてのその使用
WO2004052869A1 (en) 2002-12-12 2004-06-24 F. Hoffmann-La Roche Ag 5-substituted-pyrazine or pyridine glucokinase activators
JP2006510650A (ja) * 2002-12-12 2006-03-30 エフ．ホフマン−ラ　ロシュ　アーゲー ５置換ピラジン又はピリジングルコキナーゼ活性化物質
WO2004072066A1 (en) 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
WO2004072031A2 (en) 2003-02-11 2004-08-26 Prosidion Limited Phenylacetamides and their use as glucokinase modulators
WO2005103021A1 (en) 2004-04-21 2005-11-03 Prosidion Limited Tri(cyclo) substituted amide compounds
WO2006016194A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Substituted phenylacetamides and their use as glucokinase activators
WO2006016178A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Enantioselective process
WO2006016174A1 (en) 2004-08-12 2006-02-16 Prosidion Limited Fluorination process of protected aminothiazole
WO2006059163A1 (en) 2004-12-02 2006-06-08 Prosidion Limited Treatment of diabetes with glycogen phosphorylase inhibitors
WO2008012227A2 (en) * 2006-07-24 2008-01-31 F. Hoffmann-La Roche Ag Pyrazoles as glucokinase activators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DIABETES, vol. 41, 1992, pages 792 - 806
DIABETES, vol. 45, 1996, pages 223 - 241
FASEB J., vol. 10, 1996, pages 1213 - 1218
See also references of EP2116535A4 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5248477B2 (ja) * 2007-03-07 2013-07-31 杏林製薬株式会社 グルコキナーゼ活性化物質
US8329707B2 (en) 2008-01-18 2012-12-11 Astellas Pharma Inc. Substituted pyrazine compounds
WO2009091014A1 (ja) 2008-01-18 2009-07-23 Astellas Pharma Inc. フェニルアセトアミド誘導体
WO2009133687A1 (ja) * 2008-04-28 2009-11-05 杏林製薬株式会社 シクロペンチルアクリル酸アミド誘導体
US9452977B2 (en) 2008-04-28 2016-09-27 Kyorin Pharmaceutical Co., Ltd. Cyclopentylacrylamide derivative
US8946440B2 (en) 2008-04-28 2015-02-03 Kyorin Pharmaceutical Co., Ltd. Cyclopentylacrylamide derivative
JP5449144B2 (ja) * 2008-04-28 2014-03-19 杏林製薬株式会社 シクロペンチルアクリル酸アミド誘導体
US9096521B2 (en) 2008-08-19 2015-08-04 Janssen Pharmaceutica Nv Cold menthol receptor antagonists
JP2012512134A (ja) * 2008-08-19 2012-05-31 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷感−メントール受容体拮抗剤
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9663529B2 (en) 2013-07-02 2017-05-30 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
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EP2116535B1 (en) 2014-06-11
EP2116535A4 (en) 2013-05-29
CN101668743A (zh) 2010-03-10
US20100016304A1 (en) 2010-01-21
JP5248327B2 (ja) 2013-07-31
AR064521A1 (es) 2009-04-08
TW200831081A (en) 2008-08-01
BRPI0719470A2 (pt) 2014-02-11
CA2672088A1 (en) 2008-07-03
CL2007003722A1 (es) 2008-08-22
CA2672088C (en) 2014-11-25
AU2007337382A1 (en) 2008-07-03
KR20090096615A (ko) 2009-09-11
MX2009006907A (es) 2009-09-07
US8173649B2 (en) 2012-05-08
EP2116535A1 (en) 2009-11-11
JPWO2008078674A1 (ja) 2010-04-22

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