WO2008078674A1 - グルコキナーゼ活性化物質 - Google Patents

グルコキナーゼ活性化物質 Download PDF

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Publication number
WO2008078674A1
WO2008078674A1 PCT/JP2007/074638 JP2007074638W WO2008078674A1 WO 2008078674 A1 WO2008078674 A1 WO 2008078674A1 JP 2007074638 W JP2007074638 W JP 2007074638W WO 2008078674 A1 WO2008078674 A1 WO 2008078674A1
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Prior art keywords
group
glucokinase
activating substance
atom
asterisk
Prior art date
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PCT/JP2007/074638
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English (en)
French (fr)
Inventor
Yasumichi Fukuda
Yoshikazu Asahina
Ayako Nakamura
Kenji Fujita
Tomohiro Ide
Fumiyoshi Kobayashi
Shinji Kobayashi
Kanji Komatsu
Masanori Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Teijin Pharma Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Teijin Pharma Ltd
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Application filed by Kyorin Pharmaceutical Co Ltd, Teijin Pharma Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Priority to CN2007800517548A priority Critical patent/CN101668743B/zh
Priority to US12/448,549 priority patent/US8173649B2/en
Priority to JP2008551077A priority patent/JP5248327B2/ja
Priority to CA2672088A priority patent/CA2672088C/en
Priority to BRPI0719470-6A priority patent/BRPI0719470A2/pt
Priority to EP07851044.3A priority patent/EP2116535B1/en
Priority to MX2009006907A priority patent/MX2009006907A/es
Priority to AU2007337382A priority patent/AU2007337382A1/en
Publication of WO2008078674A1 publication Critical patent/WO2008078674A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Thiazole And Isothizaole Compounds (AREA)
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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

【解決手段】　 式（１） （式中、＊を付した炭素原子の立体配置がＲ配置であり、Ｒ１及びＲ２は、同一又は異なって水素原子、ハロゲン原子、アミノ基、水酸基、ヒドロキシアミノ基、ニトロ基、シアノ基、スルファモイル基、Ｃ１～Ｃ６のアルキル基、Ｃ１～Ｃ６のアルコキシ基、Ｃ１～Ｃ６のアルキルスルファニル基、Ｃ１～Ｃ６のアルキルスルフィニル基又はＣ１～Ｃ６のアルキルスルホニル基を示し、Ａは置換基を有してもよいヘテロアリール基を示す。）で表される化合物又は薬学的に許容されるその塩。
PCT/JP2007/074638 2006-12-25 2007-12-21 グルコキナーゼ活性化物質 Ceased WO2008078674A1 (ja)

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CN2007800517548A CN101668743B (zh) 2006-12-25 2007-12-21 葡糖激酶活化物质
US12/448,549 US8173649B2 (en) 2006-12-25 2007-12-21 Glucokinase activator
JP2008551077A JP5248327B2 (ja) 2006-12-25 2007-12-21 グルコキナーゼ活性化物質
CA2672088A CA2672088C (en) 2006-12-25 2007-12-21 Glucokinase activator
BRPI0719470-6A BRPI0719470A2 (pt) 2006-12-25 2007-12-21 "composto representado pela fórmula 1, método para tratamento ou prevenção de diabetes, uso do composto e composição farmacêutica contendo ativador de glucocinase" c07d 277/46 c07d 277/82 c07d 285/08 c07d 417/04 c07d 471/04 c07d 487/04 c07d 498/04 c07d 513/04
EP07851044.3A EP2116535B1 (en) 2006-12-25 2007-12-21 Glucokinase-activating substance
MX2009006907A MX2009006907A (es) 2006-12-25 2007-12-21 Activador de glucocinasa.
AU2007337382A AU2007337382A1 (en) 2006-12-25 2007-12-21 Glucokinase-activating substance

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WO2011123572A1 (en) 2010-03-31 2011-10-06 The Scripps Research Institute Reprogramming cells
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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WO2009091014A1 (ja) 2008-01-18 2009-07-23 Astellas Pharma Inc. フェニルアセトアミド誘導体
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9663529B2 (en) 2013-07-02 2017-05-30 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
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MX2009006907A (es) 2009-09-07
US20100016304A1 (en) 2010-01-21
CN101668743B (zh) 2012-06-20
US8173649B2 (en) 2012-05-08
BRPI0719470A2 (pt) 2014-02-11
AU2007337382A1 (en) 2008-07-03
CA2672088C (en) 2014-11-25
EP2116535A4 (en) 2013-05-29
AR064521A1 (es) 2009-04-08
EP2116535B1 (en) 2014-06-11
EP2116535A1 (en) 2009-11-11
CA2672088A1 (en) 2008-07-03
CL2007003722A1 (es) 2008-08-22
TW200831081A (en) 2008-08-01
KR20090096615A (ko) 2009-09-11
CN101668743A (zh) 2010-03-10

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