WO2008088588A3 - Biocompatible scaffold for sensing proteins - Google Patents

Biocompatible scaffold for sensing proteins Download PDF

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Publication number
WO2008088588A3
WO2008088588A3 PCT/US2007/078634 US2007078634W WO2008088588A3 WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3 US 2007078634 W US2007078634 W US 2007078634W WO 2008088588 A3 WO2008088588 A3 WO 2008088588A3
Authority
WO
WIPO (PCT)
Prior art keywords
biocompatible scaffold
conductive layer
containing nanowires
thetav
nanofibers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/078634
Other languages
French (fr)
Other versions
WO2008088588A2 (en
Inventor
Z Ryan Tian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arkansas Technology Development Foundation
Original Assignee
University of Arkansas Technology Development Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/653,192 external-priority patent/US7931812B2/en
Application filed by University of Arkansas Technology Development Foundation filed Critical University of Arkansas Technology Development Foundation
Priority to CN2007800497563A priority Critical patent/CN101646401B/en
Priority to EP07814882A priority patent/EP2101687A2/en
Publication of WO2008088588A2 publication Critical patent/WO2008088588A2/en
Publication of WO2008088588A3 publication Critical patent/WO2008088588A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

This invention related to a biocompatible scaffold that can detect redox-active chemicals and biomolecules electrochemically. In one embodiment, the biocompatible scaffold includes a substrate, and a conductive layer of Tiϑ2-containing nanowires or nano fibers formed on the substrate, wherein the conductive layer of Tiϑ2-containing nanowires or nanofibers is formed with a pore structure, and wherein when the biocompatible scaffold is in contact with a biological analyte, one or more proteins of the biological analyte are immobilized on a surface of the conductive layer Of TiO2- containing nanowires or nanofibers so as to generate a measurable faradic current signal.
PCT/US2007/078634 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins Ceased WO2008088588A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2007800497563A CN101646401B (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins
EP07814882A EP2101687A2 (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/653,192 US7931812B2 (en) 2006-01-12 2007-01-12 TiO2 nanostructures, membranes and films, and applications of same
US11/653,189 2007-01-12
US11/653,192 2007-01-12
US11/653,189 US8883115B2 (en) 2006-01-12 2007-01-12 TiO2 nanostructures, membranes and films, and methods of making same

Publications (2)

Publication Number Publication Date
WO2008088588A2 WO2008088588A2 (en) 2008-07-24
WO2008088588A3 true WO2008088588A3 (en) 2008-12-04

Family

ID=39636534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/078634 Ceased WO2008088588A2 (en) 2007-01-12 2007-09-17 Biocompatible scaffold for sensing proteins

Country Status (2)

Country Link
EP (1) EP2101687A2 (en)
WO (1) WO2008088588A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503831B2 (en) * 1997-10-14 2003-01-07 Patterning Technologies Limited Method of forming an electronic device
US6914279B2 (en) * 2002-06-06 2005-07-05 Rutgers, The State University Of New Jersey Multifunctional biosensor based on ZnO nanostructures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503831B2 (en) * 1997-10-14 2003-01-07 Patterning Technologies Limited Method of forming an electronic device
US6914279B2 (en) * 2002-06-06 2005-07-05 Rutgers, The State University Of New Jersey Multifunctional biosensor based on ZnO nanostructures

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAVYKIN D. ET AL.: "A Novel Cation Binding TiO2 Nanotube Substrate for Electro- and Bioelectro-catalysis", ELECTROCHEMISTRY COMMUNICATIONS, vol. 7, no. 10, 2005, pages 1050 - 1058, XP005082477 *
TOPOGLIDIS E. ET AL.: "Direct Electrochemistry and Nitric oxide Interaction of Heme Proteins Absorbed on Nanocrystalline Tin Oxide Electrodes", LANGMUIR, vol. 19, no. 17, 2003, pages 6894 - 6900, XP008111088 *
WEBSTER T.J. ET AL.: "Increased Osteoblast Function on PLGA Composites Containing Nanophase Titania", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 74A, no. 4, PART A, 2005, pages 677 - 686, XP008111089 *

Also Published As

Publication number Publication date
WO2008088588A2 (en) 2008-07-24
EP2101687A2 (en) 2009-09-23

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