WO2008093655A1 - ポリアルコール化合物および医薬 - Google Patents

ポリアルコール化合物および医薬 Download PDF

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Publication number
WO2008093655A1
WO2008093655A1 PCT/JP2008/051251 JP2008051251W WO2008093655A1 WO 2008093655 A1 WO2008093655 A1 WO 2008093655A1 JP 2008051251 W JP2008051251 W JP 2008051251W WO 2008093655 A1 WO2008093655 A1 WO 2008093655A1
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WO
WIPO (PCT)
Prior art keywords
compound
polyalcohol
polyalcohol compound
pharmaceutical agent
antihyperlipidemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/051251
Other languages
English (en)
French (fr)
Inventor
Hisao Nemoto
Koichiro Tsuchiya
Masaki Kamiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
University of Tokushima NUC
Original Assignee
Otsuka Pharmaceutical Co Ltd
University of Tokushima NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, University of Tokushima NUC filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP2008556097A priority Critical patent/JPWO2008093655A1/ja
Publication of WO2008093655A1 publication Critical patent/WO2008093655A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、水溶性が高く製剤化が容易である上に、必要な服用量を低減することができる抗高脂血症薬の有効成分になり得るポリアルコール化合物を提供することを目的とする。本発明のポリアルコール化合物は、下記式（Ｉ）で表される。 ［式中、Ｒは、フィブラート系抗高脂血症化合物のうちカルボキシル基またはエステル基を除いた残基を示す。Ｘは、ｎ個のポリアルコール部分をＲに結合させるための結合基を示す。ｎは１～８の整数を示す。］
PCT/JP2008/051251 2007-01-30 2008-01-29 ポリアルコール化合物および医薬 Ceased WO2008093655A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556097A JPWO2008093655A1 (ja) 2007-01-30 2008-01-29 ポリアルコール化合物および医薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007020062 2007-01-30
JP2007-020062 2007-01-30

Publications (1)

Publication Number Publication Date
WO2008093655A1 true WO2008093655A1 (ja) 2008-08-07

Family

ID=39673965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051251 Ceased WO2008093655A1 (ja) 2007-01-30 2008-01-29 ポリアルコール化合物および医薬

Country Status (2)

Country Link
JP (1) JPWO2008093655A1 (ja)
WO (1) WO2008093655A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013035899A1 (ko) * 2011-09-07 2013-03-14 주식회사 코리아테크노에이전시 5-히드록시-1, 3-디옥산의 제조 방법 및 이를 원료로 한 분기형 글리세롤 3량체의 제조 방법
WO2014141578A1 (ja) * 2013-03-15 2014-09-18 信越化学工業株式会社 対称ハイパーブランチ型シリコーン変性重合性化合物、及びそのモジュール化した製造方法
WO2020255741A1 (ja) * 2019-06-17 2020-12-24 有限会社ケミカル電子 親水性金属表面処理剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005023844A1 (ja) * 2003-09-03 2005-03-17 Kyowa Hakko Kogyo Co., Ltd. グリセロール誘導体で修飾された化合物
JP2006273849A (ja) * 2005-03-02 2006-10-12 Aska Pharmaceutical Co Ltd フェノフィブラート含有組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005023844A1 (ja) * 2003-09-03 2005-03-17 Kyowa Hakko Kogyo Co., Ltd. グリセロール誘導体で修飾された化合物
JP2006273849A (ja) * 2005-03-02 2006-10-12 Aska Pharmaceutical Co Ltd フェノフィブラート含有組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WATANABE T. ET AL.: "Studies of Hypolipidemic Agents. 1. Synthesis and Hypolipidemic Activities of Alkoxycinnamic Acid Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, 1980, pages 50 - 59, XP001007865 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2013035899A1 (ko) * 2011-09-07 2013-03-14 주식회사 코리아테크노에이전시 5-히드록시-1, 3-디옥산의 제조 방법 및 이를 원료로 한 분기형 글리세롤 3량체의 제조 방법
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014141578A1 (ja) * 2013-03-15 2014-09-18 信越化学工業株式会社 対称ハイパーブランチ型シリコーン変性重合性化合物、及びそのモジュール化した製造方法
JP2014198703A (ja) * 2013-03-15 2014-10-23 信越化学工業株式会社 対称ハイパーブランチ型シリコーン変性重合性化合物、及びそのモジュール化した製造方法
US9428527B2 (en) 2013-03-15 2016-08-30 Shin-Etsu Chemical Co., Ltd. Symmetric hyperbranched type silicone-modified polymerizable compound, and its modularized preparation method
WO2020255741A1 (ja) * 2019-06-17 2020-12-24 有限会社ケミカル電子 親水性金属表面処理剤
JP2020204076A (ja) * 2019-06-17 2020-12-24 有限会社ケミカル電子 親水性金属表面処理剤
TWI728843B (zh) * 2019-06-17 2021-05-21 日商化學電子有限公司 親水性金屬表面處理劑、將金屬的表面加以處理之方法、保護分支型甘油衍生物、以及用以製造保護分支型甘油衍生物之方法
US11124881B2 (en) 2019-06-17 2021-09-21 Chemical Denshi Co., Ltd. Hydrophilic metal surface treatment agent

Also Published As

Publication number Publication date
JPWO2008093655A1 (ja) 2010-05-20

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