WO2008100449A3 - Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury - Google Patents

Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury Download PDF

Info

Publication number
WO2008100449A3
WO2008100449A3 PCT/US2008/001755 US2008001755W WO2008100449A3 WO 2008100449 A3 WO2008100449 A3 WO 2008100449A3 US 2008001755 W US2008001755 W US 2008001755W WO 2008100449 A3 WO2008100449 A3 WO 2008100449A3
Authority
WO
WIPO (PCT)
Prior art keywords
head trauma
bryologs
bryostatins
brain injury
therapeutic effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/001755
Other languages
French (fr)
Other versions
WO2008100449A2 (en
WO2008100449A4 (en
Inventor
Ofer Zohar
Daniel L Alkon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blanchette Rockefeller Neuroscience Institute
Original Assignee
Blanchette Rockefeller Neuroscience Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blanchette Rockefeller Neuroscience Institute filed Critical Blanchette Rockefeller Neuroscience Institute
Priority to EP18153508.9A priority Critical patent/EP3332797A3/en
Priority to JP2009549130A priority patent/JP5518489B2/en
Priority to KR1020147006408A priority patent/KR20140049054A/en
Priority to ES08725395.1T priority patent/ES2548766T3/en
Priority to EP08725395.1A priority patent/EP2121000B1/en
Priority to CA002674773A priority patent/CA2674773A1/en
Priority to CN200880004009A priority patent/CN101848726A/en
Priority to PCT/US2008/006158 priority patent/WO2008143880A2/en
Publication of WO2008100449A2 publication Critical patent/WO2008100449A2/en
Publication of WO2008100449A3 publication Critical patent/WO2008100449A3/en
Publication of WO2008100449A4 publication Critical patent/WO2008100449A4/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat head trauma. Specifically, the present invention provides methods of treating head trauma comprising the steps of identifying a subject having suffered a head trauma and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of head trauma.
PCT/US2008/001755 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury Ceased WO2008100449A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP18153508.9A EP3332797A3 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury
JP2009549130A JP5518489B2 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatin, bryolog, and other related substances in head injury-induced memory impairment and brain injury
KR1020147006408A KR20140049054A (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
ES08725395.1T ES2548766T3 (en) 2007-02-09 2008-02-11 Therapeutic effects of biostatins, bryologists and other related substances in memory disorders induced by head trauma and brain injuries
EP08725395.1A EP2121000B1 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
CA002674773A CA2674773A1 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
CN200880004009A CN101848726A (en) 2007-02-09 2008-02-11 Efficacy of bryostatin, bryostatin analogs, and other related substances on memory deficits and brain damage induced by head trauma
PCT/US2008/006158 WO2008143880A2 (en) 2007-05-24 2008-05-14 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and traumatic brain injury

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US90033807P 2007-02-09 2007-02-09
US60/900,338 2007-02-09
US92466307P 2007-05-24 2007-05-24
US60/924,663 2007-05-24

Publications (3)

Publication Number Publication Date
WO2008100449A2 WO2008100449A2 (en) 2008-08-21
WO2008100449A3 true WO2008100449A3 (en) 2009-05-22
WO2008100449A4 WO2008100449A4 (en) 2009-07-30

Family

ID=39690678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001755 Ceased WO2008100449A2 (en) 2007-02-09 2008-02-11 Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury

Country Status (8)

Country Link
US (2) US9974832B2 (en)
EP (4) EP3332797A3 (en)
JP (3) JP5518489B2 (en)
KR (2) KR20090119894A (en)
CN (1) CN101848726A (en)
CA (2) CA2873179A1 (en)
ES (1) ES2548766T3 (en)
WO (1) WO2008100449A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002254029A1 (en) 2001-02-27 2002-09-12 Daniel L. Alkon Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
US20090029873A1 (en) 2005-10-11 2009-01-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb)
WO2008100450A2 (en) * 2007-02-09 2008-08-21 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury
EP3332797A3 (en) 2007-02-09 2018-08-01 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury
WO2008143880A2 (en) * 2007-05-24 2008-11-27 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and traumatic brain injury
US9994585B2 (en) 2007-12-31 2018-06-12 Aphios Corporation Transplantation therapies
US20100168219A1 (en) * 2008-12-31 2010-07-01 Jonathan Steven Alexander Chronic inflammation and transplantation
CA2731171C (en) 2008-07-28 2016-10-18 Blanchette Rockefeller Neurosciences Institute Pkc-activating compounds for the treatment of neurodegenerative diseases
EP2669386A1 (en) 2008-07-28 2013-12-04 Blanchette Rockefeller Neurosciences Institute Stimulus-elicited genomic profile markers of alzheimer's disease
US20110054040A1 (en) * 2008-12-22 2011-03-03 Department Of Biotechnology Bicyclic Triterpenoid Iripallidal as a Novel Anti-Glioma and Anti-Neoplastic Therapy
EP2483684B1 (en) 2009-10-02 2018-04-18 Blanchette Rockefeller Neurosciences, Institute Fibroblast growth patterns to diagnose alzheimer's disease
EP2483695A2 (en) 2009-10-02 2012-08-08 Blanchette Rockefeller Neurosciences, Institute Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells
US20120027687A1 (en) 2010-07-08 2012-02-02 Alkon Daniel L Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke
KR101467605B1 (en) * 2010-11-29 2014-12-04 충북대학교 산학협력단 Novel Daphnane Diterpenoid Compound and Composition for Skin Whitening Comprising the Same As Active Ingredient
EP2780316B1 (en) 2011-11-13 2020-04-15 Blanchette Rockefeller Neurosciences Institute Esters of dcpla and methods of treatment using the same
US9034347B2 (en) 2011-12-19 2015-05-19 Arphios Corporation Drug delivery system and method for the treatment of neuro-degenerative disease
CN105228614A (en) 2012-11-28 2016-01-06 阿菲欧斯公司 Be used for the treatment of combined therapy agent and the method for neurodegenerative disease and Other diseases
JP2016516201A (en) 2013-03-15 2016-06-02 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Method for identifying neuroprotective PKC activators
US11123324B2 (en) 2016-08-18 2021-09-21 Noster Inc. Immunomodulator
EP3793543A1 (en) * 2018-05-18 2021-03-24 Neurotrope Bioscience, Inc. Methods and compositions for treatment of alzheimer's disease
CN117794504A (en) * 2021-06-04 2024-03-29 捷通国际有限公司 Orris root extracts, compositions and methods for dermal applications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004641A2 (en) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute PKC ACTIVATION AS A MEANS FOR ENHANCING sAPPα SECRETION AND IMPROVING COGNITION USING BRYOSTATIN TYPE COMPOUNDS
WO2004047857A1 (en) * 2002-11-26 2004-06-10 Blanchette Rockefeller Neurosciences Institute Use of fgf-18 in the diagnosis and treatment of memory disorders
WO2006031337A2 (en) * 2004-09-10 2006-03-23 Blanchette Rockefeller Neurosciences Institute Combinations of pkc activators and pkc inhibitors for alzheimer’s disease treatment and cognitive enhancement
WO2008013573A1 (en) * 2006-07-28 2008-01-31 Blanchette Rockefeller Neurosciences Institute Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560774A (en) 1982-11-17 1985-12-24 Arizona State University Macrocyclic lactones
FI840260A7 (en) 1983-01-27 1984-07-28 Ciba Geigy Ag Pyrrolidinone derivatives and a process for their preparation.
US4611066A (en) 1984-08-10 1986-09-09 Arizona State University Bryostatins 4 to 8
US5891906A (en) * 1986-06-11 1999-04-06 Procyon Pharmaceuticals, Inc. Polyacetate-derived phorboids having anti-inflammatory and other uses
US5891870A (en) 1986-06-11 1999-04-06 Procyon Pharmaceuticals, Inc. Protein kinase C modulators Q
US6080784A (en) 1986-06-11 2000-06-27 Procyon Pharmaceuticals, Inc. Protein kinase C modulators N
US5955501A (en) 1986-06-11 1999-09-21 Procyon Pharmaceuticals, Inc. Protein kinase C modulators O
US5962498A (en) 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US6043270A (en) * 1986-06-11 2000-03-28 Procyon Pharmaceuticals, Inc. Protein kinase C modulators V
US4833257A (en) 1986-07-28 1989-05-23 Arizona Board Of Regents Compositions of matter and methods of using same
ES2061963T3 (en) 1988-01-13 1994-12-16 Univ Arizona State IMMUNOMODULATING BRIOSTATINS.
US4833139A (en) * 1988-01-25 1989-05-23 Hoechst-Roussel Pharmaceuticals, Inc. Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinones and related compounds
DE3827974A1 (en) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh COMBINATION PREPARATIONS OF PROTEINKINASE-C INHIBITORS WITH LIPIDS, LIPID ANALOGS, CYTOSTATICA OR INHIBITORS OF PHOSPHOLIPASES
US4994472A (en) 1989-08-02 1991-02-19 Hoechst-Roussel Pharmaceuticals Incorporated 1-(pyridinylamino)-2-pyrrolidinones as pain relievers
WO1991007087A1 (en) 1989-11-13 1991-05-30 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
JP2578001B2 (en) 1989-12-11 1997-02-05 明治製菓株式会社 Anti-dementia drug
DE69132531T2 (en) 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Compounds and their use in a binary synthesis strategy
US5072004A (en) * 1990-12-31 1991-12-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthetic conversion of bryostatin 2 into bryostatin 1
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5196447A (en) * 1991-08-08 1993-03-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University Neristatin 1
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
KR100310939B1 (en) 1992-10-01 2002-06-20 추후제출 Complex Combination Chemistry Library Encrypted with Tags
JPH06279311A (en) 1993-03-26 1994-10-04 Sagami Chem Res Center Activation agent for protein kinase c isozyme
US5580748A (en) * 1993-05-03 1996-12-03 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic tests for alzheimers disease
US5976816A (en) * 1993-05-03 1999-11-02 The United States Of America As Represented By The Department Of Health And Human Services Cell tests for alzheimer's disease
US5393897A (en) * 1993-07-02 1995-02-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of spongistatins 5,7,8 and 9
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
JP3647451B2 (en) 1993-09-30 2005-05-11 塩野義製薬株式会社 Benzolactam derivatives
US5545636A (en) 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5430053A (en) * 1994-04-19 1995-07-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of dictyostatin 1
US5625232A (en) * 1994-07-15 1997-04-29 Texas Instruments Incorporated Reliability of metal leads in high speed LSI semiconductors using dummy vias
PT854874E (en) 1994-11-10 2003-07-31 Pfizer MACROCYLIC LACTONE COMPOUNDS AND ITS PRODUCTION PROCESS
GB9509572D0 (en) 1995-05-11 1995-07-05 Cancer Res Campaign Tech Cancer therapy
CA2253463A1 (en) 1996-05-10 1997-11-20 Georgetown University 8-hydrocarbyl substituted benzodizocine derivatives, their preparation and their use as protein kinase c (=pkc) modulators
GB9620390D0 (en) * 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
GB9701675D0 (en) 1997-01-28 1997-03-19 Bridgeman Keith Composition for the treatment of parkinson's disease
US5962504A (en) 1997-09-08 1999-10-05 Georgetown University Substituted 2-pyrrolidinone activators of PKC
US5981168A (en) 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
US6048891A (en) * 1998-12-17 2000-04-11 Loma Linda University Medical Center Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease
DE19943198A1 (en) 1999-09-09 2001-03-15 Meyer Lucas Gmbh & Co Phosphatidyl serine-based nutritional supplement and/or therapeutic composition, useful e.g. for treating depression or Alzheimer's disease, containing docosahexaenoic acid component to improve resorption
AU784589B2 (en) * 1999-11-30 2006-05-04 Board Of Trustees Of The Leland Stanford Junior University Bryostatin analogues, synthetic methods and uses
JP2001240581A (en) 2000-02-29 2001-09-04 Senju Pharmaceut Co Ltd Aminobenzamide derivative and application
WO2001068137A2 (en) * 2000-03-14 2001-09-20 Brown University Research Foundation Compositions for regulating memory consolidation
AU2001257363A1 (en) 2000-04-28 2001-11-12 Georgetown University Rigid pyrrolidone modulators of pkc
AUPQ801700A0 (en) 2000-06-07 2000-06-29 Peplin Research Pty Ltd Enzyme and viral activation
US20030050302A1 (en) * 2000-08-31 2003-03-13 Neurologic, Inc. Treatment of conditions associated with amyloid processing using PKC activators
DE60028376T2 (en) 2000-10-09 2007-06-06 Rath, Matthias, Dr. Therapeutic combination of ascorbate with lysine and arginine for prevention and treatment of cancer
US6689385B2 (en) * 2000-11-03 2004-02-10 Chronorx Llc Formulations for the treatment of insulin resistance and type 2 diabetes mellitus
AUPR215700A0 (en) * 2000-12-19 2001-01-25 Fujisawa Pharmaceutical Co., Ltd. Carboxylic acid compound having cyclopropane ring
CZ20032338A3 (en) 2001-03-01 2004-08-18 Pfizeráproductsáinc Use of GABA A inversion agonists in combination with partial nicotine receptor agonists, estrogen, estrogen selective modulators or vitamin E when treating cognitive disorders
WO2002083877A1 (en) 2001-04-11 2002-10-24 Stem Cell Therapeutics Inc. Production of tyrosine hydroxylase positive neurons
EP1385938A1 (en) 2001-04-23 2004-02-04 Nsgene A/S Method and culture medium for producing neural cells expressing tyrosine hydroxylase
ES2314056T3 (en) 2001-05-02 2009-03-16 Blanchette Rockefeller Neurosciences Institute ACTIVATORS OF CARBON ANHYDRAINE TO IMPROVE LEARNING AND MEMORY.
CA2401452A1 (en) 2001-09-04 2003-03-04 Uri Saragovi Combination of antioxidant substances for the treatment of alzheimer's disease
JP4568464B2 (en) 2001-11-07 2010-10-27 雪印乳業株式会社 Memory disorder prevention and treatment
US6821979B2 (en) 2002-03-07 2004-11-23 Blanchette Rockefeller Neurosciences Institute Synergistic enhancement of cognitive ability
US6825229B2 (en) * 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US7803400B2 (en) * 2002-12-03 2010-09-28 Blanchette Rockefeller Neurosciences Institute Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
EA008864B1 (en) 2003-09-30 2007-08-31 Нью Ривер Фармасьютикалз Инк. Pharmaceutical compositions for of overdose or abuse
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
WO2006003137A1 (en) 2004-06-30 2006-01-12 Shell Internationale Research Maatschappij B.V. Determining in-situ the relation between seismic velocity and state of stress in an underground formation
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
WO2007044094A1 (en) 2005-10-11 2007-04-19 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)
EP3332797A3 (en) 2007-02-09 2018-08-01 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury
JP5987867B2 (en) 2014-07-10 2016-09-07 コニカミノルタ株式会社 Sheet conveying apparatus and image forming system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004641A2 (en) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute PKC ACTIVATION AS A MEANS FOR ENHANCING sAPPα SECRETION AND IMPROVING COGNITION USING BRYOSTATIN TYPE COMPOUNDS
WO2004047857A1 (en) * 2002-11-26 2004-06-10 Blanchette Rockefeller Neurosciences Institute Use of fgf-18 in the diagnosis and treatment of memory disorders
WO2006031337A2 (en) * 2004-09-10 2006-03-23 Blanchette Rockefeller Neurosciences Institute Combinations of pkc activators and pkc inhibitors for alzheimer’s disease treatment and cognitive enhancement
WO2008013573A1 (en) * 2006-07-28 2008-01-31 Blanchette Rockefeller Neurosciences Institute Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory

Also Published As

Publication number Publication date
EP2754448A2 (en) 2014-07-16
JP5518489B2 (en) 2014-06-11
JP2014088406A (en) 2014-05-15
WO2008100449A2 (en) 2008-08-21
WO2008100449A4 (en) 2009-07-30
US20080207742A1 (en) 2008-08-28
US20190083575A1 (en) 2019-03-21
EP2959914A1 (en) 2015-12-30
KR20140049054A (en) 2014-04-24
JP2016128486A (en) 2016-07-14
CA2873179A1 (en) 2008-08-21
EP2121000B1 (en) 2015-09-23
KR20090119894A (en) 2009-11-20
EP2754448A3 (en) 2014-12-24
EP3332797A3 (en) 2018-08-01
EP2121000A2 (en) 2009-11-25
EP3332797A2 (en) 2018-06-13
US9974832B2 (en) 2018-05-22
CA2674773A1 (en) 2008-08-21
CN101848726A (en) 2010-09-29
JP2010518091A (en) 2010-05-27
ES2548766T3 (en) 2015-10-20
JP6199176B2 (en) 2017-09-20

Similar Documents

Publication Publication Date Title
WO2008100449A3 (en) Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
Mattson et al. Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapy
US9107868B2 (en) Neuronal pain pathway
Qiu et al. A role for cAMP in regeneration during development and after injury
BR0316004A (en) Pharmaceutical composition comprising a cdk and gemcitabine inhibitor
ATE418991T1 (en) METHOD FOR TREATING CARDIAC RHYTHM DISORDERS USING AN A1 ADENOSINE AGONIST TOGETHER WITH A BETA BLOCKER
BR0312933A (en) Pharmaceutical composition, pharmaceutical dosage unit, method for treating one or more diseases associated with a vascular condition, and therapeutic combination.
WO2006034373A8 (en) Variants and chemically-modified variants of phenylalanine ammonia-lyase
Bersani et al. Data and hypotheses on the role of nerve growth factor and other neurotrophins in psychiatric disorders
BR0316157A (en) 4-Amino-5-phenyl-7-cyclohexyl-pyrrolo [2,3-d] pyrimidine derivatives
WO2008100450A3 (en) Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury
Nori et al. Increased nerve growth factor signaling in sensory neurons of early diabetic rats is corrected by electroacupuncture
WO2008143880A3 (en) Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and traumatic brain injury
Kiss Bimbova et al. Activation of three major signaling pathways after endurance training and spinal cord injury
WO2006099015A3 (en) Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders
TW200621788A (en) Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase Iε
Miyazato et al. Locus coeruleus involvement in the effects of immobilization stress on the p13 midlatency auditory evoked potential in the rat
Koyama et al. Increase by FK960, a novel cognitive enhancer, in glial cell line-derived neurotrophic factor production in cultured rat astrocytes
WO2005041857A3 (en) Bone morphogenetic protein (bmp) 2a and uses thereof
Wanner et al. Muscarinic receptors within the ventromedial hypothalamic nuclei modulate metabolic rate during physical exercise
BR0316029A (en) Combination
WO2001082954A3 (en) Ceruloplasmin and uses thereof in neurodegenerative related conditions
TW200621711A (en) 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I ε
BR0316021A (en) Combination comprising a cdk and cisplatin inhibitor
Daniels et al. Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880004009.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08725395

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 1232/MUMNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2674773

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2009549130

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008725395

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1020097018890

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1020147006408

Country of ref document: KR