WO2008105533A1 - カプシノイド化合物含有アディポネクチン分泌促進剤 - Google Patents

カプシノイド化合物含有アディポネクチン分泌促進剤 Download PDF

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Publication number
WO2008105533A1
WO2008105533A1 PCT/JP2008/053637 JP2008053637W WO2008105533A1 WO 2008105533 A1 WO2008105533 A1 WO 2008105533A1 JP 2008053637 W JP2008053637 W JP 2008053637W WO 2008105533 A1 WO2008105533 A1 WO 2008105533A1
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WO
WIPO (PCT)
Prior art keywords
stimulating agent
metabolic syndrome
mammal
adiponectin secretion
adiponectin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053637
Other languages
English (en)
French (fr)
Inventor
Kaori Ono
Hitoshi Satoh
Yasufumi Furuhata
Naohiko Inoue
Yoshiko Matsunaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2008105533A1 publication Critical patent/WO2008105533A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

　哺乳動物へ経口投与した場合に、アディポネクチンの産生及び分泌の亢進を介して、メタボリック症候群の予防・改善に資する物質を提供する。カプシノイド化合物、及び／又はその分解産物を有効成分として含む、哺乳動物におけるアディポネクチン分泌促進剤を提供する。このアディポネクチン分泌促進剤は、メタボリック症候群の対象者を治療するための経口投与用医薬組成物や、対象者の体重減少を伴わずにメタボリック症候群を予防及び／又は改善するための組成物として使用することができる。
PCT/JP2008/053637 2007-03-01 2008-02-29 カプシノイド化合物含有アディポネクチン分泌促進剤 Ceased WO2008105533A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-051588 2007-03-01
JP2007051588 2007-03-01

Publications (1)

Publication Number Publication Date
WO2008105533A1 true WO2008105533A1 (ja) 2008-09-04

Family

ID=39721355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053637 Ceased WO2008105533A1 (ja) 2007-03-01 2008-02-29 カプシノイド化合物含有アディポネクチン分泌促進剤

Country Status (1)

Country Link
WO (1) WO2008105533A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013031729A1 (ja) * 2011-08-26 2013-03-07 国立大学法人大阪大学 糖尿病性心血管合併症の予防・治療剤
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2629774A4 (en) * 2010-10-19 2014-08-27 Elcelyx Therapeutics Inc THERAPIES BASED ON CHEMOSOUS RECEPTOR LIGANDS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246478A (ja) * 1998-03-04 1999-09-14 Morinaga & Co Ltd エステル結合を有する新規なカプサイシノイド様物質
JP2001026538A (ja) * 1999-07-13 2001-01-30 Morinaga & Co Ltd 新規なカプサイシノイド様物質を含有する食品及び医薬組成物
JP2002114676A (ja) * 2000-10-06 2002-04-16 Morinaga & Co Ltd 新規なカプサイシノイド様物質を含有する持久力向上用組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246478A (ja) * 1998-03-04 1999-09-14 Morinaga & Co Ltd エステル結合を有する新規なカプサイシノイド様物質
JP2001026538A (ja) * 1999-07-13 2001-01-30 Morinaga & Co Ltd 新規なカプサイシノイド様物質を含有する食品及び医薬組成物
JP2002114676A (ja) * 2000-10-06 2002-04-16 Morinaga & Co Ltd 新規なカプサイシノイド様物質を含有する持久力向上用組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IWAI K. ET AL.: "Roles as metabolic regulators of the non-nutrients, capsaicin and capsiate, supplemented to diets", PROC. JAPAN ACAD., vol. 79, no. 7, 2003, pages 207 - 212, XP007909041, DOI: doi:10.2183/pjab.79b.207 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2629774A4 (en) * 2010-10-19 2014-08-27 Elcelyx Therapeutics Inc THERAPIES BASED ON CHEMOSOUS RECEPTOR LIGANDS
WO2013031729A1 (ja) * 2011-08-26 2013-03-07 国立大学法人大阪大学 糖尿病性心血管合併症の予防・治療剤
JPWO2013031729A1 (ja) * 2011-08-26 2015-03-23 国立大学法人大阪大学 糖尿病性心血管合併症の予防・治療剤
US9393224B2 (en) 2011-08-26 2016-07-19 Osaka University Prophylactic and/or therapeutic agent for cardiovascular complications of diabetes
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

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