WO2008117523A1 - 抗ウイルス剤 - Google Patents

抗ウイルス剤 Download PDF

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Publication number
WO2008117523A1
WO2008117523A1 PCT/JP2008/000655 JP2008000655W WO2008117523A1 WO 2008117523 A1 WO2008117523 A1 WO 2008117523A1 JP 2008000655 W JP2008000655 W JP 2008000655W WO 2008117523 A1 WO2008117523 A1 WO 2008117523A1
Authority
WO
WIPO (PCT)
Prior art keywords
ptgs
binding
property
suppressor protein
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/000655
Other languages
English (en)
French (fr)
Inventor
Shinsuke Sano
Takako Fukagawa
Hirokazu Yamada
Chikara Masuta
Hanako Shimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Nippon Soda Co Ltd
Original Assignee
Hokkaido University NUC
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Nippon Soda Co Ltd filed Critical Hokkaido University NUC
Priority to JP2009506204A priority Critical patent/JP5242552B2/ja
Priority to US12/450,150 priority patent/US20100216981A1/en
Priority to EP08720540A priority patent/EP2127675A4/en
Publication of WO2008117523A1 publication Critical patent/WO2008117523A1/ja
Anticipated expiration legal-status Critical
Priority to US13/067,623 priority patent/US8680158B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

　本発明は、既存のウイルス病防除方法に代わる、従来とは異なる作用機構を有し、より実用的でより安全なウイルス病防除剤を提供することを目的とする。 　本発明は、物質α（ＰＴＧＳを誘導する性質及びＰＴＧＳサプレッサータンパク質に結合する性質を有し、ＰＴＧＳサプレッサータンパク質と結合するとＰＴＧＳを誘導する性質が低下する物質）と、ＰＴＧＳサプレッサータンパク質との結合を阻害する活性を有する化合物を用いるものである。
PCT/JP2008/000655 2007-03-23 2008-03-19 抗ウイルス剤 Ceased WO2008117523A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009506204A JP5242552B2 (ja) 2007-03-23 2008-03-19 抗ウイルス剤
US12/450,150 US20100216981A1 (en) 2007-03-23 2008-03-19 Antiviral agent
EP08720540A EP2127675A4 (en) 2007-03-23 2008-03-19 ANTIVIRAL MEDIUM
US13/067,623 US8680158B2 (en) 2007-03-23 2011-06-15 Antiviral agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007077970 2007-03-23
JP2007-077970 2007-03-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/450,150 A-371-Of-International US20100216981A1 (en) 2007-03-23 2008-03-19 Antiviral agent
US13/067,623 Continuation US8680158B2 (en) 2007-03-23 2011-06-15 Antiviral agent

Publications (1)

Publication Number Publication Date
WO2008117523A1 true WO2008117523A1 (ja) 2008-10-02

Family

ID=39788265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000655 Ceased WO2008117523A1 (ja) 2007-03-23 2008-03-19 抗ウイルス剤

Country Status (4)

Country Link
US (2) US20100216981A1 (ja)
EP (1) EP2127675A4 (ja)
JP (1) JP5242552B2 (ja)
WO (1) WO2008117523A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014103321A1 (ja) * 2012-12-26 2014-07-03 学校法人北里研究所 Ｐｄｋ４阻害剤及びその利用
CN105175239B (zh) * 2015-08-21 2017-03-22 云南中烟工业有限责任公司 烟草中一种具有抗烟草花叶病毒活性的倍半萜类化合物、其制备方法和用途
WO2022074667A1 (en) * 2020-10-07 2022-04-14 Amitava Mazumder Compositions for pathogen inactivation or pathogen reduction management

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004344110A (ja) 2003-05-23 2004-12-09 Japan Science & Technology Agency 植物ウイルスの複製タンパク質およびその遺伝子の利用法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2291781A1 (en) * 1997-07-25 1999-02-04 Takara Shuzo Co., Ltd. Carcinostatics
US6927009B2 (en) * 2001-05-22 2005-08-09 Fuji Photo Film Co., Ltd. Positive photosensitive composition
DE10203135A1 (de) * 2002-01-26 2003-07-31 Call Krimhild Neue katalytische Aktivitäten von Oxidoreduktasen zur Oxidation und/oder Bleiche
US20040268441A1 (en) * 2002-07-19 2004-12-30 University Of South Carolina Compositions and methods for the modulation of gene expression in plants
WO2007005882A2 (en) * 2005-07-05 2007-01-11 North Carolina State University Methods and compositions for expressing proteins in plants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004344110A (ja) 2003-05-23 2004-12-09 Japan Science & Technology Agency 植物ウイルスの複製タンパク質およびその遺伝子の利用法

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ANANDALAKSHMI R. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 13079 - 13084
BAULCOMBE DC. ET AL., TRENDS BIOCHEM SCI., vol. 29, 2004, pages 279 - 81
BRIGNETI G. ET AL., EMBO J., vol. 17, 1998, pages 6739 - 6746
GOTO K. ET AL., PLANT CELL PHYSIOL., vol. 48, 2007, pages 1050 - 60
KOUKIEKOLO R. ET AL.: "Effects of pH and salt concentration on the siRNA binding activity of the RNA silencing suppressor protein p19", FEBS LETTERS, vol. 581, June 2007 (2007-06-01), pages 3051 - 3056, XP022117041 *
LAKATOS L. ET AL.: "Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors", THE EMBO JOURNAL, vol. 25, 2006, pages 2768 - 2780, XP008112195 *
MATSUMOTO M. ET AL.: "Selective nonpeptidic inhibitors of herpes simplex virus type 1 and human cytomegalovirus proteases", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 24, no. 3, 2001, pages 236 - 241, XP002472659 *
QU F. ET AL., J. VIROL., vol. 77, 2003, pages 511 - 522
SAGAN S.M. ET AL.: "Inhibition of siRNA Binding to a p19 Viral Suppressor of RNA Silencing by Cysteine Alkylation", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 46, no. 12, 12 March 2007 (2007-03-12), pages 2005 - 2009, XP008112178 *
See also references of EP2127675A4
VOINNET O. ET AL., CELL, vol. 103, 2000, pages 157 - 167

Also Published As

Publication number Publication date
US20120041072A1 (en) 2012-02-16
US20100216981A1 (en) 2010-08-26
JP5242552B2 (ja) 2013-07-24
EP2127675A4 (en) 2010-01-20
EP2127675A1 (en) 2009-12-02
JPWO2008117523A1 (ja) 2010-07-15
US8680158B2 (en) 2014-03-25

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