WO2008153029A1 - 特異的遺伝子発現方法 - Google Patents

特異的遺伝子発現方法 Download PDF

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Publication number
WO2008153029A1
WO2008153029A1 PCT/JP2008/060618 JP2008060618W WO2008153029A1 WO 2008153029 A1 WO2008153029 A1 WO 2008153029A1 JP 2008060618 W JP2008060618 W JP 2008060618W WO 2008153029 A1 WO2008153029 A1 WO 2008153029A1
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WO
WIPO (PCT)
Prior art keywords
expression
specific gene
oligomeric protein
natural oligomeric
endogenous polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/060618
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English (en)
French (fr)
Inventor
Junichi Mineno
Sachiko Okamoto
Risa Sumioka
Masanari Kitagawa
Hiroshi Shiku
Ikunoshin Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takara Bio Inc
Mie University NUC
Original Assignee
Takara Bio Inc
Mie University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc, Mie University NUC filed Critical Takara Bio Inc
Priority to EP08777135.8A priority Critical patent/EP2172547B1/en
Priority to CN2008801029989A priority patent/CN101815785B/zh
Priority to KR1020107000445A priority patent/KR101363928B1/ko
Priority to US12/664,133 priority patent/US9051391B2/en
Priority to JP2009519261A priority patent/JP5271901B2/ja
Publication of WO2008153029A1 publication Critical patent/WO2008153029A1/ja
Anticipated expiration legal-status Critical
Priority to US14/701,929 priority patent/US9296807B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/40—Systems of functionally co-operating vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/102—Vectors comprising a special translation-regulating system regulates levels of translation inhibiting translation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

　本発明は、非天然のオリゴマータンパク質を発現する細胞であって、天然のオリゴマータンパク質を構成する少なくとも１つの内在性ポリペプチドに対応する外来性ポリペプチドをコードする遺伝子が導入されており、かつ前記内在性ポリペプチドの発現が抑制されていることを特徴とする細胞を提供する。
PCT/JP2008/060618 2007-06-11 2008-06-10 特異的遺伝子発現方法 Ceased WO2008153029A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08777135.8A EP2172547B1 (en) 2007-06-11 2008-06-10 Method for expression of specific gene
CN2008801029989A CN101815785B (zh) 2007-06-11 2008-06-10 特异性基因表达的方法
KR1020107000445A KR101363928B1 (ko) 2007-06-11 2008-06-10 특이적 유전자 발현 방법
US12/664,133 US9051391B2 (en) 2007-06-11 2008-06-10 Method for expression of specific gene
JP2009519261A JP5271901B2 (ja) 2007-06-11 2008-06-10 特異的遺伝子発現方法
US14/701,929 US9296807B2 (en) 2007-06-11 2015-05-01 Method for expression of specific gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007154351 2007-06-11
JP2007-154351 2007-06-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/664,133 A-371-Of-International US9051391B2 (en) 2007-06-11 2008-06-10 Method for expression of specific gene
US14/701,929 Division US9296807B2 (en) 2007-06-11 2015-05-01 Method for expression of specific gene

Publications (1)

Publication Number Publication Date
WO2008153029A1 true WO2008153029A1 (ja) 2008-12-18

Family

ID=40129634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060618 Ceased WO2008153029A1 (ja) 2007-06-11 2008-06-10 特異的遺伝子発現方法

Country Status (6)

Country Link
US (2) US9051391B2 (ja)
EP (2) EP2172547B1 (ja)
JP (2) JP5271901B2 (ja)
KR (1) KR101363928B1 (ja)
CN (1) CN101815785B (ja)
WO (1) WO2008153029A1 (ja)

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WO2010101249A1 (ja) 2009-03-06 2010-09-10 国立大学法人三重大学 Ｔ細胞の機能増強方法
WO2012046727A1 (ja) 2010-10-05 2012-04-12 タカラバイオ株式会社 ウイルスベクターの製造方法
US20120321667A1 (en) * 2009-10-29 2012-12-20 Sentman Charles L T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
JP2017505621A (ja) * 2014-01-29 2017-02-23 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体を発現する細胞を生産する方法および組成物
US9790278B2 (en) 2012-05-07 2017-10-17 The Trustees Of Dartmouth College Anti-B7-H6 antibody, fusion proteins, and methods of using the same
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
WO2018143454A1 (ja) 2017-02-06 2018-08-09 国立研究開発法人国立がん研究センター 新規ｔ細胞受容体
JP2019509764A (ja) * 2016-03-15 2019-04-11 マックス−デルブリュック−セントラム フュール モルキュラー メディツィーン イン デル ヘルムホルツ−ゲマインシャフトＭａｘ−Ｄｅｌｂｒｕｃｋ−Ｃｅｎｔｒｕｍ Ｆｕｒ Ｍｏｌｅｋｕｌａｒｅｍｅｄｉｚｉｎ Ｉｎ Ｄｅｒｈｅｌｍｈｏｌｔｚ−Ｇｅｍｅｉｎｓｃｈａｆｔ 初代細胞のためのトランスポゾンに基づく転移システム
WO2019131770A1 (ja) 2017-12-27 2019-07-04 武田薬品工業株式会社 核酸含有脂質ナノ粒子及びその用途
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
WO2020013315A1 (ja) 2018-07-13 2020-01-16 国立大学法人京都大学 γδＴ細胞の製造方法
WO2020080475A1 (ja) 2018-10-18 2020-04-23 武田薬品工業株式会社 Ｔ細胞の活性化／増殖方法
WO2020262540A1 (ja) 2019-06-26 2020-12-30 武田薬品工業株式会社 トランスフェクション方法
WO2021106832A1 (ja) 2019-11-25 2021-06-03 国立大学法人京都大学 Ｔ細胞マスターセルバンク
US20220056409A1 (en) * 2009-10-29 2022-02-24 The Trustees Of Dartmouth College T-cell receptor-deficient t cell compositions
WO2022210581A1 (ja) 2021-03-31 2022-10-06 昭和電工マテリアルズ株式会社 情報管理装置及びコンピュータプログラム
WO2023022235A1 (ja) 2021-08-20 2023-02-23 大塚製薬株式会社 組み合わせ医薬

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MX345116B (es) 2008-09-15 2017-01-17 Children's Medical Center Corp Modulacion de bcl11a para tratamiento de hemoglobinopatias.
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US9399780B2 (en) 2012-03-22 2016-07-26 Takara Bio Inc. Method for producing viral vector
AU2013352156B2 (en) 2012-11-27 2018-12-06 Children's Medical Center Corporation Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
EP2975942B1 (en) * 2013-03-21 2018-08-08 Sangamo Therapeutics, Inc. Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
ES2744186T3 (es) 2014-04-25 2020-02-24 Childrens Medical Center Composiciones y métodos para tratar las hemoglobinopatías
ES2835861T5 (en) 2015-05-08 2025-02-18 Childrens Medical Ct Corp Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
ES3039670T3 (en) 2016-04-15 2025-10-23 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
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JP7748874B2 (ja) * 2019-03-04 2025-10-03 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法
CN113795583B (zh) * 2019-03-04 2026-03-27 大学健康网络 T细胞受体及其使用方法
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JP7561133B2 (ja) * 2019-03-04 2024-10-03 ユニバーシティー ヘルス ネットワーク Ｔ細胞受容体及びその使用方法
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TWI869426B (zh) * 2019-07-30 2025-01-11 大學健康網絡 Ｔ細胞受體及其使用方法
JP2023507501A (ja) * 2019-12-23 2023-02-22 ヴェルサメブ アーゲー 遺伝子の発現を同時に調節するための組成物及び方法

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JP2017035090A (ja) * 2009-03-06 2017-02-16 国立大学法人三重大学 Ｔ細胞の機能増強方法
WO2010101249A1 (ja) 2009-03-06 2010-09-10 国立大学法人三重大学 Ｔ細胞の機能増強方法
JP2018145205A (ja) * 2009-03-06 2018-09-20 国立大学法人三重大学 Ｔ細胞の機能増強方法
US9603874B2 (en) 2009-03-06 2017-03-28 Takara Bio Inc. Method for enhancing a function of a T cell
US9181525B2 (en) 2009-03-06 2015-11-10 Mie University Method for enhancing a function of a T cell
US10689616B1 (en) 2009-10-29 2020-06-23 The Trustees Of Dartmouth College T-cell receptor-deficient t cell compositions
US11834676B2 (en) 2009-10-29 2023-12-05 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
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US20120321667A1 (en) * 2009-10-29 2012-12-20 Sentman Charles L T cell receptor-deficient t cell compositions
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WO2018143454A1 (ja) 2017-02-06 2018-08-09 国立研究開発法人国立がん研究センター 新規ｔ細胞受容体
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WO2020013315A1 (ja) 2018-07-13 2020-01-16 国立大学法人京都大学 γδＴ細胞の製造方法
WO2020080475A1 (ja) 2018-10-18 2020-04-23 武田薬品工業株式会社 Ｔ細胞の活性化／増殖方法
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