WO2009001217A3 - Low-additive influenza vaccines - Google Patents

Low-additive influenza vaccines Download PDF

Info

Publication number
WO2009001217A3
WO2009001217A3 PCT/IB2008/002238 IB2008002238W WO2009001217A3 WO 2009001217 A3 WO2009001217 A3 WO 2009001217A3 IB 2008002238 W IB2008002238 W IB 2008002238W WO 2009001217 A3 WO2009001217 A3 WO 2009001217A3
Authority
WO
WIPO (PCT)
Prior art keywords
low
influenza vaccines
additive influenza
additive
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/002238
Other languages
French (fr)
Other versions
WO2009001217A2 (en
Inventor
Jens-Peter Gregersen
Holger Luebben
Juergen Vorlop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009001217(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HRP20120790AT priority Critical patent/HRP20120790T1/en
Priority to CN200880103467A priority patent/CN101784283A/en
Priority to AU2008269439A priority patent/AU2008269439B2/en
Priority to US12/666,628 priority patent/US20100183671A1/en
Priority to SI200830816T priority patent/SI2185191T1/en
Priority to EA201070066A priority patent/EA201070066A1/en
Priority to BRPI0813866-4A2A priority patent/BRPI0813866A2/en
Priority to NZ582595A priority patent/NZ582595A/en
Priority to DK08806940.6T priority patent/DK2185191T3/en
Priority to ES08806940T priority patent/ES2393162T3/en
Priority to JP2010514180A priority patent/JP2010531348A/en
Priority to EP08806940A priority patent/EP2185191B1/en
Application filed by Novartis AG filed Critical Novartis AG
Priority to PL08806940T priority patent/PL2185191T3/en
Priority to HK10109718.0A priority patent/HK1143085B/en
Priority to CA002692200A priority patent/CA2692200A1/en
Publication of WO2009001217A2 publication Critical patent/WO2009001217A2/en
Publication of WO2009001217A3 publication Critical patent/WO2009001217A3/en
Anticipated expiration legal-status Critical
Priority to US15/191,582 priority patent/US20170119871A1/en
Priority to US16/018,312 priority patent/US20190142927A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

An influenza vaccine lacks at least three of: a mercurial preservative; an antibiotic; formaldehyde; and egg-derived materials. In some embodiments, the vaccine includes none of these four components.
PCT/IB2008/002238 2007-06-27 2008-06-27 Low-additive influenza vaccines Ceased WO2009001217A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CA002692200A CA2692200A1 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
JP2010514180A JP2010531348A (en) 2007-06-27 2008-06-27 Influenza vaccine with few additives
AU2008269439A AU2008269439B2 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
US12/666,628 US20100183671A1 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
SI200830816T SI2185191T1 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
EA201070066A EA201070066A1 (en) 2007-06-27 2008-06-27 VACCINES AGAINST FLU WITH LOW CONTENT OF ADDITIVES
BRPI0813866-4A2A BRPI0813866A2 (en) 2007-06-27 2008-06-27 VACCINES AGAINST INFLUENCE WITH LOW ADDITIVE CONTENT
NZ582595A NZ582595A (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
DK08806940.6T DK2185191T3 (en) 2007-06-27 2008-06-27 Influenza vaccines with low levels of additives
HRP20120790AT HRP20120790T1 (en) 2007-06-27 2008-06-27 INFLUENCES WITH LOW ADDITIVES
EP08806940A EP2185191B1 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
CN200880103467A CN101784283A (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
ES08806940T ES2393162T3 (en) 2007-06-27 2008-06-27 Influenza vaccines with reduced additive content
PL08806940T PL2185191T3 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
HK10109718.0A HK1143085B (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
US15/191,582 US20170119871A1 (en) 2007-06-27 2016-06-24 Low-additive influenza vaccines
US16/018,312 US20190142927A1 (en) 2007-06-27 2018-06-26 Low-additive influenza vaccines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93751507P 2007-06-27 2007-06-27
US60/937,515 2007-06-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/666,628 A-371-Of-International US20100183671A1 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines
US15/191,582 Continuation US20170119871A1 (en) 2007-06-27 2016-06-24 Low-additive influenza vaccines

Publications (2)

Publication Number Publication Date
WO2009001217A2 WO2009001217A2 (en) 2008-12-31
WO2009001217A3 true WO2009001217A3 (en) 2009-08-13

Family

ID=40076631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002238 Ceased WO2009001217A2 (en) 2007-06-27 2008-06-27 Low-additive influenza vaccines

Country Status (19)

Country Link
US (3) US20100183671A1 (en)
EP (2) EP2185191B1 (en)
JP (1) JP2010531348A (en)
KR (1) KR20100045437A (en)
CN (1) CN101784283A (en)
AU (1) AU2008269439B2 (en)
BR (1) BRPI0813866A2 (en)
CA (1) CA2692200A1 (en)
CY (1) CY1113738T1 (en)
DK (1) DK2185191T3 (en)
EA (1) EA201070066A1 (en)
ES (1) ES2393162T3 (en)
HR (1) HRP20120790T1 (en)
NZ (1) NZ582595A (en)
PL (1) PL2185191T3 (en)
PT (1) PT2185191E (en)
SG (1) SG182957A1 (en)
SI (1) SI2185191T1 (en)
WO (1) WO2009001217A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101472941B (en) 2006-03-31 2017-08-08 沃弗-威斯康星校友研究基金会 High titer recombinant influenza viruses for vaccine
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
JP2012521786A (en) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ Influenza virus vaccine and use thereof
JP2013507990A (en) 2009-10-26 2013-03-07 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション High-titer recombinant influenza virus with enhanced replication in Vero cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
MX2012011300A (en) 2010-03-30 2012-11-29 Sinai School Medicine Influenza virus vaccines and uses thereof.
CN102858961A (en) 2010-05-03 2013-01-02 葛兰素史密丝克莱恩生物有限公司 Novel method
CN102939104A (en) 2010-06-01 2013-02-20 诺华有限公司 Concentration of vaccine antigens with lyophilization
KR102113512B1 (en) 2010-06-01 2020-05-22 노파르티스 아게 Concentration of influenza vaccine antigens without lyophilization
ES2531577T3 (en) 2010-08-20 2015-03-17 Novartis Ag Needle sets for administration of soluble flu vaccine
ES2655051T3 (en) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Influenza virus with mutant PB2 gene segment as live attenuated vaccines
HK1200102A1 (en) 2011-09-20 2015-07-31 西奈山医学院 Influenza virus vaccines and uses thereof
NZ627796A (en) 2012-12-18 2017-07-28 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
EP3247389A4 (en) 2015-01-23 2019-10-30 Icahn School of Medicine at Mount Sinai VACCINATION REGIMES FOR INFLUENZA VIRUSES
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
KR101766313B1 (en) 2015-09-09 2017-08-08 조동휘 method of mature alcohol using a fermentation pine leaf
CN105349499B (en) * 2015-11-06 2018-12-07 张澍 A kind of preparation method of bird flu whole virus particles marker vaccine and products thereof and purposes
CN109477074B (en) 2016-02-19 2023-01-24 威斯康星旧生研究基金会 Improved influenza b virus replication for vaccine development
MX2018015755A (en) 2016-06-15 2019-08-29 Icahn School Med Mount Sinai Influenza virus hemagglutinin proteins and uses thereof.
CA3058652A1 (en) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka Recombinant influenza viruses with stabilized ha for replication in eggs
JP7432506B2 (en) 2017-10-30 2024-02-16 武田薬品工業株式会社 Environmentally compatible surfactants for inactivating lipid enveloped viruses
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
JP7783047B2 (en) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant biologically contained filovirus vaccines
EP3840780A1 (en) 2018-08-20 2021-06-30 Wisconsin Alumni Research Foundation Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein
WO2020167432A2 (en) 2019-01-23 2020-08-20 Yoshihiro Kawaoka Mutations that confer genetic stability to additional genes in influenza viruses
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
CA3137160A1 (en) 2019-04-24 2020-10-29 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
US12226478B2 (en) 2019-04-28 2025-02-18 Gholam A. Peyman Method of treating, reducing, or alleviating a medical condition in a patient
US11707518B2 (en) * 2019-04-28 2023-07-25 Gholam A. Peyman Method of treating, reducing, or alleviating a medical condition in a patient
CN114929269A (en) 2019-05-01 2022-08-19 威斯康星校友研究基金会(Warf) Improved influenza virus replication for vaccine development
JP7627911B2 (en) 2019-08-27 2025-02-07 ウィスコンシン アルムニ リサーチ ファンデイション Recombinant influenza viruses with stabilized HA for replication in egg
EP4093415A1 (en) 2020-01-24 2022-11-30 Wisconsin Alumni Research Foundation (WARF) Recombinant influenza viruses with stabilized na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19612966A1 (en) * 1996-04-01 1997-10-02 Behringwerke Ag Animal cells and methods for the propagation of influenza viruses
EP1605052A2 (en) * 1993-09-13 2005-12-14 Mg-Pmc, L.L.C. A method for producing influenza hemagglutinin multivalent vaccines
EP1676569A1 (en) * 2004-12-30 2006-07-05 Pevion Biotech Ltd. Lyophilization of virosomes
US20060252132A1 (en) * 2003-06-16 2006-11-09 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
WO2007052163A2 (en) * 2005-11-01 2007-05-10 Novartis Vaccines And Diagnostics Gmbh & Co Kg Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment
WO2007052061A2 (en) * 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics Srl Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060082A (en) 1976-08-16 1977-11-29 Mpl, Inc. Dual-ingredient medication dispenser
SE8205892D0 (en) 1982-10-18 1982-10-18 Bror Morein IMMUNOGENT MEMBRANE PROTEIN COMPLEX, SET FOR PREPARATION AND USE THEREOF
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US6090406A (en) 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US5916588A (en) 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
US5011828A (en) 1985-11-15 1991-04-30 Michael Goodman Immunostimulating guanine derivatives, compositions and methods
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
AU627226B2 (en) 1988-08-25 1992-08-20 Liposome Company, Inc., The Influenza vaccine and novel adjuvants
US5238944A (en) 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US4929624A (en) 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
WO1990014837A1 (en) 1989-05-25 1990-12-13 Chiron Corporation Adjuvant formulation comprising a submicron oil droplet emulsion
US4988815A (en) 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5658731A (en) 1990-04-09 1997-08-19 Europaisches Laboratorium Fur Molekularbiologie 2'-O-alkylnucleotides as well as polymers which contain such nucleotides
EP0872478B1 (en) 1991-03-01 2002-12-18 Minnesota Mining And Manufacturing Company Intermediates for the preparation of 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5389640A (en) 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
JPH0614756Y2 (en) 1991-06-26 1994-04-20 株式会社アルテ Assembled dual chamber syringe
US5936076A (en) 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
US5268376A (en) 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
MA22842A1 (en) 1992-03-27 1993-10-01 Smithkline Beecham Biolog PROCESS FOR THE PREPARATION OF VACCINE COMPOSITIONS.
IL105325A (en) 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
CA2138997C (en) 1992-06-25 2003-06-03 Jean-Paul Prieels Vaccine composition containing adjuvants
US5395937A (en) 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
SG48309A1 (en) 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
KR100341341B1 (en) 1993-07-15 2002-11-25 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 IMIDAZO[4,5-c]PYRIDIN-4-AMINES
US5352784A (en) 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
AU5543294A (en) 1993-10-29 1995-05-22 Pharmos Corp. Submicron emulsions as vaccine adjuvants
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US5496284A (en) 1994-09-27 1996-03-05 Waldenburg; Ottfried Dual-chamber syringe & method
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
US5482936A (en) 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
GB9503863D0 (en) 1995-02-25 1995-04-19 Smithkline Beecham Biolog Vaccine compositions
UA56132C2 (en) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Vaccine composition (variants), method for stabilizing qs21 providing resistance against hydrolysis (variants), method for manufacturing vaccine
JP2000512263A (en) 1995-10-20 2000-09-19 イースム リサーチ ディベロップメント カンパニー オブ ザ ヒーブル ユニバーシティ オブ エルサレム Flu vaccine
DE19612967A1 (en) 1996-04-01 1997-10-02 Behringwerke Ag Process for the propagation of influenza viruses in cell culture, and the influenza viruses obtainable by the process
WO1998001174A1 (en) 1996-07-05 1998-01-15 Debiotech S.A. Dual-chamber syringe for mixing two substances prior to injection
AU753688B2 (en) 1997-03-10 2002-10-24 Ottawa Civic Loeb Research Institute Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
TW570803B (en) 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
US5971953A (en) 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
WO1999017820A1 (en) 1997-10-03 1999-04-15 Texas Pharmaceuticals, Inc. Improved dual chamber syringe apparatus
GB9725084D0 (en) 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
WO1999052549A1 (en) 1998-04-09 1999-10-21 Smithkline Beecham Biologicals S.A. Adjuvant compositions
HK1039072A1 (en) 1998-05-07 2002-04-12 科里克萨有限公司 Adjuvant composition and methods for its use
US6562798B1 (en) 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
US6110929A (en) 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
GB9817052D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Biolog Vaccine
DE19835749C1 (en) 1998-08-07 2000-02-03 Dieter Perthes Ready-to-use syringe for unstable drugs
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
AT408615B (en) 1998-09-15 2002-01-25 Immuno Ag NEW INFLUENCE VIRUS VACCINE COMPOSITION
AU750587B2 (en) 1998-10-16 2002-07-25 Smithkline Beecham Biologicals (Sa) Adjuvant systems and vaccines
US20030130212A1 (en) 1999-01-14 2003-07-10 Rossignol Daniel P. Administration of an anti-endotoxin drug by intravenous infusion
US6551600B2 (en) 1999-02-01 2003-04-22 Eisai Co., Ltd. Immunological adjuvant compounds compositions and methods of use thereof
CA2361421A1 (en) 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
EP1955709B1 (en) 1999-03-26 2012-03-14 Vical Incorporated Adjuvant compositions for enhancing immune responses to polynucleotide-based vaccines
EP1185615B1 (en) 1999-04-06 2007-08-01 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
DE122007000070I1 (en) 1999-07-14 2008-01-31 Sinai School Medicine In Vitro Reconstitution of Segmented Negative Strand Rna Viruses
JP2003509473A (en) 1999-09-24 2003-03-11 スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム vaccine
KR20020038771A (en) 1999-09-24 2002-05-23 장 스테판느 Intranasal influenza virus vaccine
CO5200838A1 (en) 1999-09-24 2002-09-27 Smithkline Beecham Corp VACCINES
IL148843A0 (en) 1999-09-25 2002-09-12 Univ Iowa Res Found Immunostimulatory nucleic acids
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
US20010044416A1 (en) 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
EP1260581B1 (en) 2000-03-03 2010-07-07 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell
PL205955B1 (en) 2000-04-28 2010-06-30 St Jude Childrens Res Hospital Dna transfection system for the generation of infectious influenza virus
FR2808803B1 (en) 2000-05-11 2004-12-10 Agronomique Inst Nat Rech MODIFIED ES CELLS AND SPECIFIC GENE OF ES CELLS
US7407662B2 (en) * 2000-06-29 2008-08-05 Lipid Sciences, Inc. Modified viral particles with immunogenic properties and reduced lipid content
JP4341949B2 (en) 2000-09-01 2009-10-14 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Azaheterocyclic derivatives and their therapeutic use
JP4361727B2 (en) 2000-09-11 2009-11-11 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Quinolinone derivatives as tyrosine kinase inhibitors
ATE384072T1 (en) 2000-09-26 2008-02-15 Idera Pharmaceuticals Inc MODULATION OF THE IMMUNOSTIMULATIVE ACTIVITY OF IMMUNOSTIMULATIVE OLIGONUCLEOTIDE ANALOGS THROUGH POSITIONAL CHEMICAL CHANGES
GB0024089D0 (en) 2000-10-02 2000-11-15 Smithkline Beecham Biolog Novel compounds
US6677347B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
US6664264B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6664265B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
UA74852C2 (en) 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
US6677348B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6660735B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Urea substituted imidazoquinoline ethers
US6660747B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6667312B2 (en) 2000-12-08 2003-12-23 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6664260B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Heterocyclic ether substituted imidazoquinolines
US20040096463A1 (en) 2001-02-23 2004-05-20 Nathalie Garcon Novel vaccine
DE60239594D1 (en) 2001-02-23 2011-05-12 Glaxosmithkline Biolog Sa INFLUENZA VACCINE COMPOSITIONS FOR INTRADERMAL ADMINISTRATION
ATE489968T1 (en) 2001-03-09 2010-12-15 Id Biomedical Corp Quebec PROTEOSOME-LIPOSACCHARIDE VACCINE ADJUVANT
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
DE10144903A1 (en) 2001-09-12 2003-03-27 Chiron Behring Gmbh & Co Replication of virus in cell cultures, useful for preparing vaccines and diagnostic reagents, where replication of cells and virus is simultaneous
DE10144906B4 (en) 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Process for the large-scale production of vaccines
WO2003035836A2 (en) 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
FR2832423B1 (en) 2001-11-22 2004-10-08 Vivalis EXOGENOUS PROTEIN EXPRESSION SYSTEM IN AN AVIAN SYSTEM
US7321033B2 (en) 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
CN1300165C (en) 2001-11-27 2007-02-14 安那迪斯药品股份有限公司 3-β-ribofuranosylthiazolo[4,5-d]pyrimidine nucleoside and its application
US6677349B1 (en) 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
FR2836924B1 (en) 2002-03-08 2005-01-14 Vivalis AVIAN CELL LINES USEFUL FOR THE PRODUCTION OF INTEREST SUBSTANCES
ATE447404T1 (en) 2002-03-29 2009-11-15 Novartis Vaccines & Diagnostic SUBSTITUTED BENZAZOLES AND THEIR USE AS RAF-KINASE INHIBITORS
AU2003233519A1 (en) 2002-05-29 2003-12-19 3M Innovative Properties Company Process for imidazo(4,5-c)pyridin-4-amines
CA2493690C (en) 2002-06-13 2011-11-08 New York University Synthetic c-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases
SE0202110D0 (en) 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
JP2006501243A (en) 2002-08-23 2006-01-12 カイロン コーポレイション A pyrrole-based inhibitor of glycogen synthase kinase 3
US7521062B2 (en) 2002-12-27 2009-04-21 Novartis Vaccines & Diagnostics, Inc. Thiosemicarbazones as anti-virals and immunopotentiators
EP1594524B1 (en) 2003-01-21 2012-08-15 Novartis Vaccines and Diagnostics, Inc. Use of tryptanthrin compounds for immune potentiation
GB0301554D0 (en) 2003-01-23 2003-02-26 Molecularnature Ltd Immunostimulatory compositions
EP2258365B1 (en) 2003-03-28 2013-05-29 Novartis Vaccines and Diagnostics, Inc. Use of organic compounds for immunopotentiation
SE0301998D0 (en) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
RU2236257C1 (en) 2003-09-15 2004-09-20 Косяков Константин Сергеевич Synthetic immunogen for therapy and prophylaxis of addiction with narcotic and psychoactive substances
US7771726B2 (en) 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
EP1528101A1 (en) 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
ES2416311T3 (en) 2004-03-23 2013-07-31 Nipro Corporation Prefilled syringe
WO2005102049A1 (en) 2004-03-31 2005-11-03 New York University Novel synthetic c-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
JP5393978B2 (en) 2004-04-05 2014-01-22 ゾエティス・ピー・エルエルシー Microfluidized oil-in-water emulsion and vaccine composition
WO2005113756A1 (en) 2004-05-14 2005-12-01 Glaxosmithkline Biologicals S.A. Method
NZ551640A (en) 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
CA2571421A1 (en) 2004-06-24 2006-01-05 Nicholas Valiante Compounds for immunopotentiation
PT1789084E (en) 2004-09-09 2011-02-22 Novartis Vaccines & Diagnostic Decreasing potential iatrogenic risks associated with influenza vaccines
DK2368975T3 (en) 2004-12-23 2015-01-05 Medimmune Llc Non-tumorigenic MDCK cell line for the propagation of viruses
EP2295542B1 (en) 2004-12-24 2013-01-30 Abbott Biologicals B.V. Rescue of influenza virus
US7572620B2 (en) * 2005-01-11 2009-08-11 Wisconsin Alumni Research Foundation H3 equine influenza A virus
FR2884255B1 (en) 2005-04-11 2010-11-05 Vivalis USE OF EBX AVIATION STEM CELL LINES FOR THE PRODUCTION OF INFLUENZA VACCINE
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion
CA2657648A1 (en) * 2006-07-13 2008-01-17 Emory University Virosomes, methods of preparation, and immunogenic compositions
SG10201404101RA (en) * 2007-08-28 2014-09-26 Baxter Int Method For Producing Viral Vaccines

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1605052A2 (en) * 1993-09-13 2005-12-14 Mg-Pmc, L.L.C. A method for producing influenza hemagglutinin multivalent vaccines
DE19612966A1 (en) * 1996-04-01 1997-10-02 Behringwerke Ag Animal cells and methods for the propagation of influenza viruses
US20060252132A1 (en) * 2003-06-16 2006-11-09 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
EP1676569A1 (en) * 2004-12-30 2006-07-05 Pevion Biotech Ltd. Lyophilization of virosomes
WO2007052163A2 (en) * 2005-11-01 2007-05-10 Novartis Vaccines And Diagnostics Gmbh & Co Kg Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment
WO2007052061A2 (en) * 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics Srl Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ID BIOMEDICAL CORPORATION OF QUEBEC: "Highlights of prescribing information Flulaval", 2006, pages 1 - 12, XP002513142, Retrieved from the Internet <URL:http://www.fda.gov/CBER/label/flulavalLB.pdf> [retrieved on 20090203] *
KESSLER N ET AL: "SUITABILITY OF MDCK CELLS GROWN IN A SERUM-FREE MEDIUM FOR INFLUENZA VIRUS PRODUCTION", DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, KARGER, BASEL, CH, vol. 98, 1 January 1999 (1999-01-01), pages 13 - 21,73/74, XP001097586, ISSN: 0301-5149 *
MERTEN O-W ET AL: "PRODUCTION OF INFLUENZA VIRUS IN SERUM-FREE MAMMALIAN CELL CULTURES", DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, KARGER, BASEL, CH, vol. 98, 1 January 1997 (1997-01-01), pages 23 - 37, XP000909398, ISSN: 0301-5149 *
REICHELDERFER P S ET AL: "REDUCTION OF ENDO TOXIN LEVELS IN INFLUENZA VIRUS VACCINES BY BARIUM SULFATE ADSORPTION ELUTION", APPLIED MICROBIOLOGY, vol. 30, no. 2, 1975, pages 333 - 334, XP002513140, ISSN: 0003-6919 *
SANOFI PASTEUR: "Highlights of prescribing information Fluzone", 1980, pages 1 - 16, XP002513141, Retrieved from the Internet <URL:http://www.fda.gov/CBER/label/fluzoneLB.pdf> [retrieved on 20090203] *

Also Published As

Publication number Publication date
AU2008269439B2 (en) 2013-12-19
WO2009001217A2 (en) 2008-12-31
AU2008269439A1 (en) 2008-12-31
JP2010531348A (en) 2010-09-24
BRPI0813866A2 (en) 2015-01-06
SG182957A1 (en) 2012-08-30
EP2185191A2 (en) 2010-05-19
NZ582595A (en) 2012-07-27
CN101784283A (en) 2010-07-21
HK1143085A1 (en) 2010-12-24
US20170119871A1 (en) 2017-05-04
EA201070066A1 (en) 2010-06-30
SI2185191T1 (en) 2012-12-31
US20190142927A1 (en) 2019-05-16
KR20100045437A (en) 2010-05-03
CY1113738T1 (en) 2016-06-22
PT2185191E (en) 2012-11-27
HRP20120790T1 (en) 2013-01-31
DK2185191T3 (en) 2012-12-03
EP2484377A1 (en) 2012-08-08
PL2185191T3 (en) 2013-02-28
CA2692200A1 (en) 2008-12-31
EP2185191B1 (en) 2012-09-12
ES2393162T3 (en) 2012-12-19
US20100183671A1 (en) 2010-07-22

Similar Documents

Publication Publication Date Title
EA201070066A1 (en) VACCINES AGAINST FLU WITH LOW CONTENT OF ADDITIVES
WO2008153610A3 (en) Use of il-23 antagonists for treatment of infection
IL220152A (en) Combination comprising dronedarone and ranolazine, a pharmaceutical formulation comprising the same and uses thereof
WO2010119343A8 (en) Compositions for immunising against staphylococcus aureus
AU2013201592A1 (en) Improved vaccines and methods for using the same
WO2007079448A3 (en) Three component carbohydrate vaccine
WO2012006487A3 (en) Fluoropolymer blend and articles thereof
BR112012004335A2 (en) compound, pharmaceutical composition, and use of the compound.
WO2010006144A3 (en) Influenza hemagglutinin and neuraminidase variants
EP2170382A4 (en) An attenuated influenza virus and a live vaccine comprising the same
ZA201008348B (en) Alcohol alkoxylates, agents comprising the same and use of the alcohol alkoxylates as adjuvants in the agrochemical field.
BRPI0919412A8 (en) immunonutritional and nutritional composition, immune response enhancing agent and its use.
IL206808A (en) Indolyl-pyridone derivatives, pharmaceutical compositions comprising the same and uses thereof
WO2010101967A3 (en) Phosphothiophene and phosphothiazole hcv polymerase inhibitors
WO2008020322A3 (en) Combination vaccines with 1-hydroxy-2-phenoxyethane preservative
WO2015074213A8 (en) Composition for preventing and curing mycoplasma infection
BRPI0913175A2 (en) antiballistic article, and, use of it.
EP2119451A4 (en) Lyophilized preparation comprising influenza vaccine, and method for preparation thereof
BRPI0721988A2 (en) interferon alfa 2a modified by polyethylene glycol, the preparation and use thereof.
EP2397150A4 (en) BIOPOLYMER, IMPLANT COMPRISING THE SAME AND CORRESPONDING USES
WO2012125525A3 (en) Equine rhinitis vaccine
MX341805B (en) Pesticide formulation with streaming birefringence.
BRPI0923402A2 (en) C10rf59 peptides and vaccines including the same.
BRPI0817230A2 (en) inactivated influenza vaccine, and use of the vaccine
WO2010110931A3 (en) Glycoconjugate vaccines

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880103467.1

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08806940

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2692200

Country of ref document: CA

Ref document number: MX/A/2009/014272

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 4439/KOLNP/2009

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 12666628

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2010514180

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 582595

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2008269439

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 20107001171

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 201070066

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 2008806940

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008269439

Country of ref document: AU

Date of ref document: 20080627

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: PI0813866

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20091223