WO2009001817A1 - １１β－ＨＳＤ１阻害活性を有する化合物 - Google Patents

１１β－ＨＳＤ１阻害活性を有する化合物 Download PDF

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WO2009001817A1
WO2009001817A1 PCT/JP2008/061452 JP2008061452W WO2009001817A1 WO 2009001817 A1 WO2009001817 A1 WO 2009001817A1 JP 2008061452 W JP2008061452 W JP 2008061452W WO 2009001817 A1 WO2009001817 A1 WO 2009001817A1
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group
compound
inhibitory activity
hydrogen atom
atom
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French (fr)
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Ryo Suzuki
Ayako Mikami
Hiroaki Tanaka
Hiroshi Fukushima
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Taisho Pharmaceutical Co Ltd
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Taisho Pharmaceutical Co Ltd
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Priority to EP08790584A priority Critical patent/EP2172453A4/en
Priority to JP2009520591A priority patent/JP5223864B2/ja
Priority to US12/666,802 priority patent/US8222417B2/en
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Abstract

優れた１１β－ＨＳＤ１阻害活性を有する化合物を提供する。 下記式（I） ［式（I）中、 Ｘ1は、酸素原子、又は式－（ＣＲ11Ｒ12）p－等を示し、 Ｙ1は、水素原子、ヒドロキシル基、等を示し、 Ｚ1は、酸素原子、又は式－（ＮＲ14）－を示し、 Ｒ1は、水素原子、ハロゲン原子、シアノ基、Ｃ1-4アルキル基、１～３個のハロゲン原子で置換されたＣ1-4アルキル基、Ｃ1-4アルコキシ基、Ｃ1-4アルコキシカルボニル基、カルボキシル基、カルバモイル基、又はアミノ基を示し、ｍは、１又は２の整数を示し、 Ｒ2は、水素原子、又はＣ1-4アルキル基を示し、ｎは、１又は２の整数を示す。］ で表される化合物。
PCT/JP2008/061452 2007-06-27 2008-06-24 １１β－ＨＳＤ１阻害活性を有する化合物 Ceased WO2009001817A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08790584A EP2172453A4 (en) 2007-06-27 2008-06-24 CONNECTION WITH 11-β-HSD1 INHIBITING ACTIVITY
JP2009520591A JP5223864B2 (ja) 2007-06-27 2008-06-24 １１β−ＨＳＤ１阻害活性を有する化合物
US12/666,802 US8222417B2 (en) 2007-06-27 2008-06-24 Compound having 11β-HSD1 inhibitory activity

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007169824 2007-06-27
JP2007-169824 2007-06-27
JP2007207294 2007-08-08
JP2007-207294 2007-08-08
JP2007315236 2007-12-05
JP2007-315236 2007-12-05

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WO2009001817A1 true WO2009001817A1 (ja) 2008-12-31

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US (1) US8222417B2 (ja)
EP (1) EP2172453A4 (ja)
JP (1) JP5223864B2 (ja)
WO (1) WO2009001817A1 (ja)

Cited By (18)

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JP2011510919A (ja) * 2008-01-28 2011-04-07 サノフイ−アベンテイス テトラヒドロキノキサリン尿素誘導体、これらの調製、および治療的適用
WO2011059021A1 (ja) * 2009-11-11 2011-05-19 大日本住友製薬株式会社 ８－アザビシクロ［３．２．１］オクタン－８－カルボキサミド誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012029942A1 (ja) * 2010-09-03 2012-03-08 大日本住友製薬株式会社 環状アミド誘導体
JP2012528865A (ja) * 2009-06-02 2012-11-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１βヒドロキシステロイドデヒドロゲナーゼ１のカルバマート及びウレアインヒビター
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2021507929A (ja) * 2017-12-27 2021-02-25 ビーピー オイル インターナショナル リミテッドＢｐ Ｏｉｌ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 燃料添加物の調製方法
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JP2015521652A (ja) * 2012-07-04 2015-07-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ カンナビノイド受容体２アゴニストとしての新規アダマンチル誘導体
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