WO2009006478A3 - 6-disubstituted bicyclic nucleic acid analogs - Google Patents

6-disubstituted bicyclic nucleic acid analogs Download PDF

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Publication number
WO2009006478A3
WO2009006478A3 PCT/US2008/068922 US2008068922W WO2009006478A3 WO 2009006478 A3 WO2009006478 A3 WO 2009006478A3 US 2008068922 W US2008068922 W US 2008068922W WO 2009006478 A3 WO2009006478 A3 WO 2009006478A3
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WO
WIPO (PCT)
Prior art keywords
disubstituted bicyclic
oligomeric compounds
nucleic acid
acid analogs
bicyclic nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/068922
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French (fr)
Other versions
WO2009006478A2 (en
Inventor
Eric E Swayze
Punit P Seth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40087523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009006478(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DK08781239.2T priority Critical patent/DK2176280T4/en
Priority to EP08781239.2A priority patent/EP2176280B2/en
Priority to AT08781239T priority patent/ATE538127T1/en
Priority to AU2008272918A priority patent/AU2008272918B2/en
Priority to CA2692579A priority patent/CA2692579C/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Priority to US12/667,684 priority patent/US8278283B2/en
Priority to CN200880105715.6A priority patent/CN101796062B/en
Priority to ES08781239.2T priority patent/ES2376507T5/en
Publication of WO2009006478A2 publication Critical patent/WO2009006478A2/en
Publication of WO2009006478A3 publication Critical patent/WO2009006478A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present disclosure describes 6-disubstituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the 6-disubstituted bicyclic nucleosides each comprise a 2'-O-C(Ri)(R2)-4' or 2'-O- C=(R3)(R.4)-4' bridge wherein each R is, independently a substituent group and Ri and R2 include H. The 6-disubstituted bicyclic nucleosides are useful for enhancing properties of oligomeric compounds including nuclease resistance. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
PCT/US2008/068922 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs Ceased WO2009006478A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES08781239.2T ES2376507T5 (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs
EP08781239.2A EP2176280B2 (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs
AT08781239T ATE538127T1 (en) 2007-07-05 2008-07-01 6-DISUBSTITUTED BICYCLIC NUCLEIC ACID ANALOGUES
AU2008272918A AU2008272918B2 (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs
CA2692579A CA2692579C (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs
DK08781239.2T DK2176280T4 (en) 2007-07-05 2008-07-01 6-Disubstituerede bicykliske nukleinsyreanaloge
US12/667,684 US8278283B2 (en) 2007-07-05 2008-07-01 6-disubstituted or unsaturated bicyclic nucleic acid analogs
CN200880105715.6A CN101796062B (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94813407P 2007-07-05 2007-07-05
US60/948,134 2007-07-05

Publications (2)

Publication Number Publication Date
WO2009006478A2 WO2009006478A2 (en) 2009-01-08
WO2009006478A3 true WO2009006478A3 (en) 2009-02-19

Family

ID=40087523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/068922 Ceased WO2009006478A2 (en) 2007-07-05 2008-07-01 6-disubstituted bicyclic nucleic acid analogs

Country Status (9)

Country Link
US (1) US8278283B2 (en)
EP (1) EP2176280B2 (en)
CN (1) CN101796062B (en)
AT (1) ATE538127T1 (en)
AU (1) AU2008272918B2 (en)
CA (1) CA2692579C (en)
DK (1) DK2176280T4 (en)
ES (1) ES2376507T5 (en)
WO (1) WO2009006478A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
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US11077195B2 (en) 2019-02-06 2021-08-03 Synthorx, Inc. IL-2 conjugates and methods of use thereof
US11279929B2 (en) 2018-07-03 2022-03-22 Hoffmann-La Roche, Inc. Oligonucleotides for modulating Tau expression

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