WO2009014201A1 - 表面被覆無機物粒子の製造方法 - Google Patents

表面被覆無機物粒子の製造方法 Download PDF

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WO2009014201A1
WO2009014201A1 PCT/JP2008/063361 JP2008063361W WO2009014201A1 WO 2009014201 A1 WO2009014201 A1 WO 2009014201A1 JP 2008063361 W JP2008063361 W JP 2008063361W WO 2009014201 A1 WO2009014201 A1 WO 2009014201A1
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Prior art keywords
inorganic particles
coating substance
fatty acid
polar solvent
dispersible
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Ceased
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PCT/JP2008/063361
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English (en)
French (fr)
Inventor
Hiroshi Handa
Mamoru Hatakeyama
Masanori Abe
Satoshi Sakamoto
Yuka Masaike
Kosuke Nishio
Yoshinori Kita
Hiroshi Kishi
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Tokyo Institute of Technology NUC
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Tokyo Institute of Technology NUC
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Application filed by Tokyo Institute of Technology NUC filed Critical Tokyo Institute of Technology NUC
Priority to US12/670,807 priority Critical patent/US8852555B2/en
Priority to CN2008801006563A priority patent/CN101765562B/zh
Priority to JP2009524516A priority patent/JP5569837B2/ja
Priority to CA2694536A priority patent/CA2694536A1/en
Priority to EP08791605A priority patent/EP2184262B1/en
Publication of WO2009014201A1 publication Critical patent/WO2009014201A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
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    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
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    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
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    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
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    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
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    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
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    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
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Abstract

　粒子サイズがよく揃い粒径が精密に制御されたナノサイズの無機物粒子が有機溶媒中での合成によって得られるようになったものの、その無機物粒子には長鎖の脂肪酸が粒子表面に吸着しているため極性溶媒中での分散が阻害されており、しかもこの表面被覆を置換して極性溶媒中で分散するナノサイズの無機物粒子を得ることが困難であった。脂肪酸で被覆された無機物粒子が分散している非極性溶媒中に、チオリンゴ酸などの一時被覆物質を添加して粒子の脂肪酸被覆をまずこの一時被覆物質被覆で置換し、次にこの一時被覆物質で被覆された無機物粒子を極性溶媒に分散し、この分散液にクエン酸などの極性溶媒分散性被覆物質を添加し、無機物粒子を被覆している一時被覆物質被覆をこの極性溶媒分散性被覆物質で置換することによって、脂肪酸で被覆された無機物粒子から極性溶媒中で分散するさまざまな表面被覆無機物粒子を得ることができるようになった。
PCT/JP2008/063361 2007-07-26 2008-07-25 表面被覆無機物粒子の製造方法 Ceased WO2009014201A1 (ja)

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JP2014088603A (ja) * 2012-10-31 2014-05-15 Nippon Steel & Sumikin Chemical Co Ltd 分散性ニッケル微粒子スラリーの製造方法
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JP2022033609A (ja) * 2020-08-17 2022-03-02 株式会社日本触媒 金属酸化物ナノ粒子、金属酸化物ナノ粒子を含む組成物及びその硬化物
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JP2013505569A (ja) * 2009-09-21 2013-02-14 ビーエーエスエフ ソシエタス・ヨーロピア 切換え可能な強磁性ナノ粒子を含む基板
JP2013535991A (ja) * 2010-06-21 2013-09-19 ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション 生物医学向けにチューニングされた多機能性磁性ナノ粒子
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JP2014517764A (ja) * 2011-04-11 2014-07-24 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 金属クラスターおよびナノ粒子が封入された安定酸化物
JP2013087308A (ja) * 2011-10-14 2013-05-13 Nippon Steel & Sumikin Chemical Co Ltd 金属ナノ粒子及びその製造方法
JP2014088603A (ja) * 2012-10-31 2014-05-15 Nippon Steel & Sumikin Chemical Co Ltd 分散性ニッケル微粒子スラリーの製造方法
JP2022033609A (ja) * 2020-08-17 2022-03-02 株式会社日本触媒 金属酸化物ナノ粒子、金属酸化物ナノ粒子を含む組成物及びその硬化物
JP7522606B2 (ja) 2020-08-17 2024-07-25 株式会社日本触媒 金属酸化物ナノ粒子、金属酸化物ナノ粒子を含む組成物及びその硬化物
WO2025197226A1 (ja) * 2024-03-19 2025-09-25 株式会社村田製作所 軟磁性金属磁性粉、インダクタ、および、軟磁性金属磁性粉の製造方法

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