WO2009016608A3 - Pharmaceutical compositions of fenofibrate - Google Patents

Pharmaceutical compositions of fenofibrate Download PDF

Info

Publication number
WO2009016608A3
WO2009016608A3 PCT/IB2008/053091 IB2008053091W WO2009016608A3 WO 2009016608 A3 WO2009016608 A3 WO 2009016608A3 IB 2008053091 W IB2008053091 W IB 2008053091W WO 2009016608 A3 WO2009016608 A3 WO 2009016608A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
fenofibrate
relates
compositions
micronized fenofibrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/053091
Other languages
French (fr)
Other versions
WO2009016608A2 (en
Inventor
Rahul Dabre
Roshanlal Sandal
Vikrant Thakkar
Girish Kumar Jain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Research Centre
Original Assignee
Wockhardt Research Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Research Centre filed Critical Wockhardt Research Centre
Priority to EP08789518A priority Critical patent/EP2190415A2/en
Priority to US12/671,832 priority patent/US20100285126A1/en
Publication of WO2009016608A2 publication Critical patent/WO2009016608A2/en
Publication of WO2009016608A3 publication Critical patent/WO2009016608A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to pharmaceutical compositions comprising non-micronized fenofibrate with one or more pharmaceutically acceptable vehicles. The invention also relates to pharmaceutical compositions comprising non-micronized fenofibrate with one or more cyclodextrin derivatives. The invention also relates to processes for the preparation of such compositions.
PCT/IB2008/053091 2007-08-02 2008-08-01 Pharmaceutical compositions of fenofibrate Ceased WO2009016608A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08789518A EP2190415A2 (en) 2007-08-02 2008-08-01 Pharmaceutical compositions of fenofibrate
US12/671,832 US20100285126A1 (en) 2007-08-02 2008-08-01 Pharmaceutical compositions of fenofibrate

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
IN1487MU2007 2007-08-02
IN1487/MUM/2007 2007-08-02
IN1486MU2007 2007-08-02
IN1486/MUM/2007 2007-08-02
IN1488/MUM/2007 2007-08-02
IN1484/MUM/2007 2007-08-02
IN1485/MUM/2007 2007-08-02
IN1488MU2007 2007-08-02
IN1485MU2007 2007-08-02
IN1484MU2007 2007-08-02
IN600/MUM/2008 2008-03-24
IN600MU2008 2008-03-24

Publications (2)

Publication Number Publication Date
WO2009016608A2 WO2009016608A2 (en) 2009-02-05
WO2009016608A3 true WO2009016608A3 (en) 2009-05-28

Family

ID=40174794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053091 Ceased WO2009016608A2 (en) 2007-08-02 2008-08-01 Pharmaceutical compositions of fenofibrate

Country Status (2)

Country Link
EP (1) EP2190415A2 (en)
WO (1) WO2009016608A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2865371B1 (en) * 2013-10-22 2016-08-10 Disphar International B.V. Fast dissolving granules
JP6787389B2 (en) 2016-02-26 2020-11-18 株式会社ニコン Detection device, detection system, detection method, information processing device, and processing program
CN107126420A (en) * 2017-05-09 2017-09-05 上海信谊万象药业股份有限公司 A kind of high-dissolution fenofibrate and preparation method thereof
CN107469091B (en) * 2017-07-25 2020-09-22 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） Magnetic fenofibrate-cyclodextrin inclusion compound

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002414A2 (en) * 2002-06-28 2004-01-08 Shire Laboratories Inc. Self-emulsifying formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability and/or reduced food effect
US20040157797A1 (en) * 2003-02-03 2004-08-12 Rong-Kun Chang Drug formulation and delivery using crystalline methylated cyclodextrins
WO2005034920A1 (en) * 2003-10-10 2005-04-21 Lifecycle Pharma A/S A solid dosage form comprising a fibrate
US20050096391A1 (en) * 2003-10-10 2005-05-05 Per Holm Compositions comprising fenofibrate and rosuvastatin
WO2006037348A1 (en) * 2004-10-01 2006-04-13 Lifecycle Pharma A/S Pharmaceutical compositions comprising fenofibrate and a statin
EP1707197A1 (en) * 2005-03-30 2006-10-04 Teva Pharmaceutical Industries Ltd. Formulations containing fenofibrate and a surfactant mixture

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002414A2 (en) * 2002-06-28 2004-01-08 Shire Laboratories Inc. Self-emulsifying formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability and/or reduced food effect
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
US20040157797A1 (en) * 2003-02-03 2004-08-12 Rong-Kun Chang Drug formulation and delivery using crystalline methylated cyclodextrins
WO2005034920A1 (en) * 2003-10-10 2005-04-21 Lifecycle Pharma A/S A solid dosage form comprising a fibrate
US20050096391A1 (en) * 2003-10-10 2005-05-05 Per Holm Compositions comprising fenofibrate and rosuvastatin
WO2006037348A1 (en) * 2004-10-01 2006-04-13 Lifecycle Pharma A/S Pharmaceutical compositions comprising fenofibrate and a statin
EP1707197A1 (en) * 2005-03-30 2006-10-04 Teva Pharmaceutical Industries Ltd. Formulations containing fenofibrate and a surfactant mixture

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AIGNER Z ET AL: "INCREASING THE SOLUBILITY CHARACTERISTICS OF FENOFIBRATE WITH CYCLODEXTRIN", JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION INCHEMISTRY, KLUWER, DORDRECHT, NL, vol. 20, 1 January 1995 (1995-01-01), pages 241 - 252, XP009041938, ISSN: 0923-0750 *
PALMIERI G F ET AL: "INCLUSION COMPLEXATION OF FENOFIBRATE WITH BETA-CYCLODEXTRIN AND HYDROXYPROPYL-BETA-CYCLODEXTRIN. EVALUATION OF INTERACTIONS IN SOLUTION AND SOLID COMPLEX CHARACTERIZATION", SCIENCES TECHNIQUES ET PRATIQUES STP PHARMA SCIENCES, PARIS, FR, vol. 7, no. 2, 1 January 1997 (1997-01-01), pages 174 - 181, XP009041885, ISSN: 1157-1489 *
SHEU ET AL: "Characterization and dissolution of fenofibrate solid dispersion systems", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 103, no. 2, 1 January 1994 (1994-01-01), pages 137 - 146, XP002091325, ISSN: 0378-5173 *

Also Published As

Publication number Publication date
WO2009016608A2 (en) 2009-02-05
EP2190415A2 (en) 2010-06-02

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